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Conserved domains on  [gi|1831518085|ref|NP_001366887|]
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CUB-like domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUB_2 pfam02408
CUB-like domain; This is a family of hypothetical C. elegans proteins. The aligned region has ...
 17-127 1.01e-22

CUB-like domain; This is a family of hypothetical C. elegans proteins. The aligned region has no known function nor do any of the proteins which possess it. However, this domain is related to the CUB domain.


:

Pssm-ID: 280554  Cd Length: 120  Bit Score: 91.67  E-value: 1.01e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518085  17 AAQFSCPLNTISKNNGMSGSIP-------PGAASMVQVPAGSTCTFKFDIPKGFALKIETTA----DYDISKRDSIKFDD 85
Cdd:pfam02408   1 AAGFTCPSGTITINKPVNGSIPvyypntwNGSMEPPKIPANQNCSWNINVPKGYYAKVIISAktndDSSITVTDSLGNSE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1831518085  86 FYITSPAEKKieYAVRKTLPYNVVSKSGSLKFFATYTYVDIS 127
Cdd:pfam02408  81 YVTDSDNEPY--FFVSPSFTINLSTGSGSVSFGFKVQWSPYP 120
BBS2_N super family cl20704
Ciliary BBSome complex subunit 2, N-terminal; The BBSome (so-named after the association with ...
 214-278 1.23e-03

Ciliary BBSome complex subunit 2, N-terminal; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.


The actual alignment was detected with superfamily member pfam14781:

Pssm-ID: 464314  Cd Length: 107  Bit Score: 38.00  E-value: 1.23e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1831518085 214 LTLLNLYRTPSdSLfisnDASAVKKYDQYKILVVSSANQIsgLMYNFHDNADAWYTIICDGCNSI 278
Cdd:pfam14781  47 VSLLNINQAVT-AL----TAGRLDPDSGRDILLVGTQTNL--LAYDVENNSDLFYKEVPDGVNAI 104
 
Name Accession Description Interval E-value
CUB_2 pfam02408
CUB-like domain; This is a family of hypothetical C. elegans proteins. The aligned region has ...
 17-127 1.01e-22

CUB-like domain; This is a family of hypothetical C. elegans proteins. The aligned region has no known function nor do any of the proteins which possess it. However, this domain is related to the CUB domain.


Pssm-ID: 280554  Cd Length: 120  Bit Score: 91.67  E-value: 1.01e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518085  17 AAQFSCPLNTISKNNGMSGSIP-------PGAASMVQVPAGSTCTFKFDIPKGFALKIETTA----DYDISKRDSIKFDD 85
Cdd:pfam02408   1 AAGFTCPSGTITINKPVNGSIPvyypntwNGSMEPPKIPANQNCSWNINVPKGYYAKVIISAktndDSSITVTDSLGNSE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1831518085  86 FYITSPAEKKieYAVRKTLPYNVVSKSGSLKFFATYTYVDIS 127
Cdd:pfam02408  81 YVTDSDNEPY--FFVSPSFTINLSTGSGSVSFGFKVQWSPYP 120
BBS2_N pfam14781
Ciliary BBSome complex subunit 2, N-terminal; The BBSome (so-named after the association with ...
 214-278 1.23e-03

Ciliary BBSome complex subunit 2, N-terminal; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.


Pssm-ID: 464314  Cd Length: 107  Bit Score: 38.00  E-value: 1.23e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1831518085 214 LTLLNLYRTPSdSLfisnDASAVKKYDQYKILVVSSANQIsgLMYNFHDNADAWYTIICDGCNSI 278
Cdd:pfam14781  47 VSLLNINQAVT-AL----TAGRLDPDSGRDILLVGTQTNL--LAYDVENNSDLFYKEVPDGVNAI 104
 
Name Accession Description Interval E-value
CUB_2 pfam02408
CUB-like domain; This is a family of hypothetical C. elegans proteins. The aligned region has ...
 17-127 1.01e-22

CUB-like domain; This is a family of hypothetical C. elegans proteins. The aligned region has no known function nor do any of the proteins which possess it. However, this domain is related to the CUB domain.


Pssm-ID: 280554  Cd Length: 120  Bit Score: 91.67  E-value: 1.01e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518085  17 AAQFSCPLNTISKNNGMSGSIP-------PGAASMVQVPAGSTCTFKFDIPKGFALKIETTA----DYDISKRDSIKFDD 85
Cdd:pfam02408   1 AAGFTCPSGTITINKPVNGSIPvyypntwNGSMEPPKIPANQNCSWNINVPKGYYAKVIISAktndDSSITVTDSLGNSE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1831518085  86 FYITSPAEKKieYAVRKTLPYNVVSKSGSLKFFATYTYVDIS 127
Cdd:pfam02408  81 YVTDSDNEPY--FFVSPSFTINLSTGSGSVSFGFKVQWSPYP 120
BBS2_N pfam14781
Ciliary BBSome complex subunit 2, N-terminal; The BBSome (so-named after the association with ...
 214-278 1.23e-03

Ciliary BBSome complex subunit 2, N-terminal; The BBSome (so-named after the association with Bardet-Biedl syndrome) is a complex of 8 subunits that lies at the base of the flagellar microtubule structure. The precise function of the all the individual components in cilia formation is unclear, however they function to promote loading of cargo to the ciliary axoneme. The primary cilium, a slim microtubule-based organelle that projects from the surface of vertebrate cells has crucial roles in vertebrate development and human genetic diseases. Cilia are required for the response to developmental signals, and evidence is accumulating that the primary cilium is specialized for Hedgehog (Hh) signal transduction. Formation of cilia, in turn, is regulated by other signalling pathways, possibly including the planar cell polarity pathway. The connections between cilia and developmental signalling have begun to clarify the basis of human diseases associated with ciliary dysfunction. BBS2 is one of the three Bardet-Biedl syndrome subunits that is required for leptin receptor signalling in the hypothalamus, and BBS2 and 4 are also required for the localization of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia.


Pssm-ID: 464314  Cd Length: 107  Bit Score: 38.00  E-value: 1.23e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1831518085 214 LTLLNLYRTPSdSLfisnDASAVKKYDQYKILVVSSANQIsgLMYNFHDNADAWYTIICDGCNSI 278
Cdd:pfam14781  47 VSLLNINQAVT-AL----TAGRLDPDSGRDILLVGTQTNL--LAYDVENNSDLFYKEVPDGVNAI 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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