NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1831507496|ref|NP_001368505|]
View 

G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

G-protein coupled receptor( domain architecture ID 11606548)

G-protein coupled receptor (GPCR) transmits physiological signals from the outside of the cell to the inside by binding to an extracellular agonist, which induces conformational changes that lead to the activation of heterotrimeric G proteins, which then bind to and activate numerous downstream effector proteins

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
40-352 6.66e-69

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


:

Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 219.04  E-value: 6.66e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496  40 YFHRYACLFICIVGVFSNAIHIAVLSRPRMRRcAVNSVLTAVAFCDVITMTSYSIYLMRFRFYETD-HGYSYIWLVFLKF 118
Cdd:cd14978     1 VLYGYVLPVICIFGIIGNILNLVVLTRKSMRS-STNVYLAALAVSDILVLLSALPLFLLPYIADYSsSFLSYFYAYFLPY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 119 HVWSSMTLHAITLYMGGALAFIRWQALGNIHS--KWLQPRNSWQLFGVVSVVLSIVCLPTLVLHKIYEIESPEIETSTVs 196
Cdd:cd14978    80 IYPLANTFQTASVWLTVALTVERYIAVCHPLKarTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYY- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 197 evlrlsgqsipkevRYSLNFSTYSCAFFKFNLWMLAIVLKAIPCALLLWFTIALVVKLRQTDEKRNyLYSKSFRKHVKKT 276
Cdd:cd14978   159 --------------VIPTLLRQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRRR-LLRRRRRLLSRSQ 223
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1831507496 277 TVPDRTTYMLIIMLVVFLVTELPQGFLALLNGLYTGDVNIYIYKNLSELLDFLSLINCSVDFLLYCVMSSRYRQTF 352
Cdd:cd14978   224 RRERRTTIMLIAVVIVFLICNLPAGILNILEAIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
 
Name Accession Description Interval E-value
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
40-352 6.66e-69

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 219.04  E-value: 6.66e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496  40 YFHRYACLFICIVGVFSNAIHIAVLSRPRMRRcAVNSVLTAVAFCDVITMTSYSIYLMRFRFYETD-HGYSYIWLVFLKF 118
Cdd:cd14978     1 VLYGYVLPVICIFGIIGNILNLVVLTRKSMRS-STNVYLAALAVSDILVLLSALPLFLLPYIADYSsSFLSYFYAYFLPY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 119 HVWSSMTLHAITLYMGGALAFIRWQALGNIHS--KWLQPRNSWQLFGVVSVVLSIVCLPTLVLHKIYEIESPEIETSTVs 196
Cdd:cd14978    80 IYPLANTFQTASVWLTVALTVERYIAVCHPLKarTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYY- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 197 evlrlsgqsipkevRYSLNFSTYSCAFFKFNLWMLAIVLKAIPCALLLWFTIALVVKLRQTDEKRNyLYSKSFRKHVKKT 276
Cdd:cd14978   159 --------------VIPTLLRQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRRR-LLRRRRRLLSRSQ 223
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1831507496 277 TVPDRTTYMLIIMLVVFLVTELPQGFLALLNGLYTGDVNIYIYKNLSELLDFLSLINCSVDFLLYCVMSSRYRQTF 352
Cdd:cd14978   224 RRERRTTIMLIAVVIVFLICNLPAGILNILEAIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7TM_GPCR_Srw pfam10324
Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis ...
48-356 2.71e-37

Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.


Pssm-ID: 402097  Cd Length: 318  Bit Score: 136.95  E-value: 2.71e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496  48 FICIVGVFSNAIHIAVLSRPRMRRCAVNSVLTAVAFCDVITM--TSYSIYLMRFRFYETDH--GYSYIWLVFLKFHVWSs 123
Cdd:pfam10324   5 ILSFIGFIINIFHLIILTRKSMRTSSINIIMIGIAICDIITMllTIYNFIPEFIISYENSEciPPDSYLKVLLDWILES- 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 124 mtLHAITL----YMGGALAFIRW----QALGNIHSKWLQPRNSWQLFGVVSVVLSIVCLPTLVLHKIYEIESPEIETSTV 195
Cdd:pfam10324  84 --LQDYSRrcstWLGVFMALIRTlvvkNPMSNKIQKLSKPKFGLIIIIIVFILSLPISIFYYFRYEIVEVGGIWKPPPNC 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 196 SEVlrlsgQSIPKEVRYSLN----FSTYSCAFFKFNLWMLAIVLKAIPCALLLWFTIALVVKLRQTDEKRnylySKSFRK 271
Cdd:pfam10324 162 AGF-----PPNYTETRYVLVvselFTANDGLLLKIFLLIDGIFSKIIPCILLPILTILLIIELRKAKKSR----KNLSSS 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 272 HVKKTtvpDRTTYMLIIMLVVFLVTELPQGFLALLNGLYTGDVNI-YIYKNLSELLDFLSLINCSVDFLLYCVMSSRYRQ 350
Cdd:pfam10324 233 SKNKS---DRTTKLVIFMTISFFIAEFPLGISYIIQFFFTDNPGIrRILTYLSVIFSLLFTINSISHCFICFLMSSQYRK 309

                  ....*.
gi 1831507496 351 TFGHML 356
Cdd:pfam10324 310 TAKKLF 315
 
Name Accession Description Interval E-value
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
40-352 6.66e-69

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 219.04  E-value: 6.66e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496  40 YFHRYACLFICIVGVFSNAIHIAVLSRPRMRRcAVNSVLTAVAFCDVITMTSYSIYLMRFRFYETD-HGYSYIWLVFLKF 118
Cdd:cd14978     1 VLYGYVLPVICIFGIIGNILNLVVLTRKSMRS-STNVYLAALAVSDILVLLSALPLFLLPYIADYSsSFLSYFYAYFLPY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 119 HVWSSMTLHAITLYMGGALAFIRWQALGNIHS--KWLQPRNSWQLFGVVSVVLSIVCLPTLVLHKIYEIESPEIETSTVs 196
Cdd:cd14978    80 IYPLANTFQTASVWLTVALTVERYIAVCHPLKarTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYY- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 197 evlrlsgqsipkevRYSLNFSTYSCAFFKFNLWMLAIVLKAIPCALLLWFTIALVVKLRQTDEKRNyLYSKSFRKHVKKT 276
Cdd:cd14978   159 --------------VIPTLLRQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRRR-LLRRRRRLLSRSQ 223
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1831507496 277 TVPDRTTYMLIIMLVVFLVTELPQGFLALLNGLYTGDVNIYIYKNLSELLDFLSLINCSVDFLLYCVMSSRYRQTF 352
Cdd:cd14978   224 RRERRTTIMLIAVVIVFLICNLPAGILNILEAIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7TM_GPCR_Srw pfam10324
Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis ...
48-356 2.71e-37

Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.


Pssm-ID: 402097  Cd Length: 318  Bit Score: 136.95  E-value: 2.71e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496  48 FICIVGVFSNAIHIAVLSRPRMRRCAVNSVLTAVAFCDVITM--TSYSIYLMRFRFYETDH--GYSYIWLVFLKFHVWSs 123
Cdd:pfam10324   5 ILSFIGFIINIFHLIILTRKSMRTSSINIIMIGIAICDIITMllTIYNFIPEFIISYENSEciPPDSYLKVLLDWILES- 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 124 mtLHAITL----YMGGALAFIRW----QALGNIHSKWLQPRNSWQLFGVVSVVLSIVCLPTLVLHKIYEIESPEIETSTV 195
Cdd:pfam10324  84 --LQDYSRrcstWLGVFMALIRTlvvkNPMSNKIQKLSKPKFGLIIIIIVFILSLPISIFYYFRYEIVEVGGIWKPPPNC 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 196 SEVlrlsgQSIPKEVRYSLN----FSTYSCAFFKFNLWMLAIVLKAIPCALLLWFTIALVVKLRQTDEKRnylySKSFRK 271
Cdd:pfam10324 162 AGF-----PPNYTETRYVLVvselFTANDGLLLKIFLLIDGIFSKIIPCILLPILTILLIIELRKAKKSR----KNLSSS 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 272 HVKKTtvpDRTTYMLIIMLVVFLVTELPQGFLALLNGLYTGDVNI-YIYKNLSELLDFLSLINCSVDFLLYCVMSSRYRQ 350
Cdd:pfam10324 233 SKNKS---DRTTKLVIFMTISFFIAEFPLGISYIIQFFFTDNPGIrRILTYLSVIFSLLFTINSISHCFICFLMSSQYRK 309

                  ....*.
gi 1831507496 351 TFGHML 356
Cdd:pfam10324 310 TAKKLF 315
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
45-345 1.11e-07

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 52.68  E-value: 1.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496  45 ACLFICIVGVFSNAIHIAVLSRPRMRRCAVNSVLTAVAFCDVITmtsySIYLMRFRFYETDHGYSYIWLVFLKFHVWSSM 124
Cdd:cd00637     4 LYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLV----GLLVIPFSLVSLLLGRWWFGDALCKLLGFLQS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 125 TLHAITLYMGGALAFIRWQALGN--IHSKWLQPRNSWQLFGVVSVVLSIVCLPTLVLHKIYEIESPeietstvsevlrls 202
Cdd:cd00637    80 VSLLASILTLTAISVDRYLAIVHplRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGY-------------- 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 203 gqsipkevrYSLNFSTYSCAFFKFNLWMLAIVLKAIPCALLLWFTIALVVKLRQTDEKRNYLYSKSFRKHVKKTTVpdRT 282
Cdd:cd00637   146 ---------CCCCLCWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRRRRRER--KV 214
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1831507496 283 TYMLIIMLVVFLVTELPQGFLALLNglYTGDVNIYIYKNLSELLDFLSLINCSVDFLLYCVMS 345
Cdd:cd00637   215 TKTLLIVVVVFLLCWLPYFILLLLD--VFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
46-352 6.05e-06

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 47.35  E-value: 6.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496  46 CLFICIVGVFSNAIHIAVLSRPRMRRCAVNSVLTAVAFCDVITMtsysIYLMRFRFYETDHGYSYIWLVFL-KFHVWSSM 124
Cdd:cd14979     7 YVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLIL----LVGLPVELYNFWWQYPWAFGDGGcKLYYFLFE 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 125 TLHAITLYMGGALAFIRWQALGN-IHSKWL-QPRNSWQLFGVVSVVLSIVCLPTLVLHKIYEIESPEIETSTVSEVLRLs 202
Cdd:cd14979    83 ACTYATVLTIVALSVERYVAICHpLKAKTLvTKRRVKRFILAIWLVSILCAIPILFLMGIQYLNGPLPGPVPDSAVCTL- 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 203 gqsIPKEVRYSLNFSTYSCAFFKFNLWMLAIVLKAIPCALLLWFTIALVVKLRQTDEKRNYLySKSFRKHVKKttvpdrt 282
Cdd:cd14979   162 ---VVDRSTFKYVFQVSTFIFFVLPMFVISILYFRIGVKLRSMRNIKKGTRAQGTRNVELSL-SQQARRQVVK------- 230
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1831507496 283 tyMLIIMLVVFLVTELPQGFLALLNGLYTGDVNIY--IYKNLSELLDFLSLINCSVDFLLYCVMSSRYRQTF 352
Cdd:cd14979   231 --MLGAVVIAFFVCWLPFHAQRLMFSYASKEDTFLfdFYQYLYPISGILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
49-352 1.91e-05

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 46.05  E-value: 1.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496  49 ICIVGVFSNAIHIAVLSRPRMRRCAVNSVLTAVAFCD------VITMT---------SYSIYLMRFrfyetdhgYSYIWL 113
Cdd:cd14993    10 VFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADllvslfCMPLTllenvyrpwVFGEVLCKA--------VPYLQG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 114 VFLkfhVWSSMTLHAItlymggalAFIRWQALGN-IHSKWLQP-RNSWQLFGVVSVVLSIVCLPTLVLHKIYEIESPEIE 191
Cdd:cd14993    82 VSV---SASVLTLVAI--------SIDRYLAICYpLKARRVSTkRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSEPG 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 192 TSTVSevlrlsgqsIPKEVRYSLNFSTYscaffkFNLWMLaIVLKAIPCAL--LLWFTIALVVKLRQTDEKRNYLYSKSF 269
Cdd:cd14993   151 TITIY---------ICTEDWPSPELRKA------YNVALF-VVLYVLPLLIisVAYSLIGRRLWRRKPPGDRGSANSTSS 214
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 270 RKHVKKTTvpdRTTYMLIIMLVVFLVTELP---QGFLALLNGLYTGDVNiYIYKNLSELLDFLSLINCSVDFLLYCVMSS 346
Cdd:cd14993   215 RRILRSKK---KVARMLIVVVVLFALSWLPyyvLSILLDFGPLSSEESD-ENFLLILPFAQLLGYSNSAINPIIYCFMSK 290

                  ....*.
gi 1831507496 347 RYRQTF 352
Cdd:cd14993   291 KFRRGF 296
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
48-352 8.55e-04

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 40.81  E-value: 8.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496  48 FICIVGVFSNAIHIA-VLSRPRMR--------RCAVNSVLTAVaFCdvITMTSYS-IYLMRFRFYETD-HGYSYIWLVfl 116
Cdd:cd15392     9 TIFVLAVGGNGLVCYiVVSYPRMRtvtnyfivNLALSDILMAV-FC--VPFSFIAlLILQYWPFGEFMcPVVNYLQAV-- 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 117 kfhvwsSMTLHAITLYmggALAFIRWQALGNIHSKWLQPRNSWQLFGVVSVVLSIVCLPTLvlhkiyeiespeIETSTVS 196
Cdd:cd15392    84 ------SVFVSAFTLV---AISIDRYVAIMWPLRPRMTKRQALLLIAVIWIFALATALPIA------------ITSRLFE 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 197 EVLRLSGQSIPKEVRYSLNFS-TYScaffkfnlWMLAIVLKAIPCALLLwFT---IALVVKLRQT----DEKRNYLYSKS 268
Cdd:cd15392   143 DSNASCGQYICTESWPSDTNRyIYS--------LVLMILQYFVPLAVLV-FTytrIGIVVWAKRTpgeaENNRDQRMAES 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 269 FRKHVKkttvpdrttyMLIIMLVVFLVTELPQGFLALLNGLYTGDVNIYIYKNLSELLDFLSLINCSVDFLLYCVMSSRY 348
Cdd:cd15392   214 KRKLVK----------MMITVVAIFALCWLPLNILNLVGDHDESIYSWPYIPYLWLAAHWLAMSHCCYNPFIYCWMNAKF 283

                  ....
gi 1831507496 349 RQTF 352
Cdd:cd15392   284 RNGF 287
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
228-349 2.08e-03

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 39.50  E-value: 2.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 228 LWMLAIVLKAIPCALLLWFTIALVVKLRQTDEKRNYLYSKSfrkhvkkttvpdRTTYMLIIMLVVFLVTELPQGFLALLN 307
Cdd:cd15919   158 IWIHCFTVYLVPCSIFFVLNSIIVYKLRRKSNFRLRGYSTG------------KTTAILFTITSIFAILWAPRIIMILYH 225
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1831507496 308 GLYTGDVNIYIYKNLSELLDFLSLINCSVDFLLYCVMSSRYR 349
Cdd:cd15919   226 LYVSPINNSWLVHIVSDIANMLALLNTAINFFLYCFISKRFR 267
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
47-346 2.23e-03

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 39.51  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496  47 LFICIVGVFSNAIHIAVLSRPRMRRCAVNSVLTAVAFCDvITMTSYSiylMRFRFYETdhgYSYIW--------LVFLKF 118
Cdd:cd15203     8 GLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSD-LLLCLVS---LPFTLIYT---LTKNWpfgsilckLVPSLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 119 HV---WSSMTLHAItlymggalAFIRWQALGNIHSKWLQPRNSWQLFGVVSVVLSIVCLPTLVLHKIYEIESPEIETSTV 195
Cdd:cd15203    81 GVsifVSTLTLTAI--------AIDRYQLIVYPTRPRMSKRHALLIIALIWILSLLLSLPLAIFQELSDVPIEILPYCGY 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 196 -------SEVLRLsgqsipkevryslnfsTYScaffkfnlWMLAIVLKAIPCALL--LWFTIALVVKLRQTDEKRNYLYS 266
Cdd:cd15203   153 fcteswpSSSSRL----------------IYT--------ISVLVLQFVIPLLIIsfCYFRISLKLRKRVKKKRGKRTLS 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 267 KSFRKHVKKTTvpDRTTYMLIIMLVVFLVTELPQGFLALLNGLytgDVNIYIYKNLSELLDFLSLIncsvdfllyCVMSS 346
Cdd:cd15203   209 SRRRRSELRRK--RRTNRLLIAMVVVFAVCWLPLNLFNLLRDF---EPLPQIDGRHFYLIFLICHL---------IAMSS 274
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
46-352 4.08e-03

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 38.79  E-value: 4.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496  46 CLFICIVGVFSNAIHIAVLSRPRMRRCAVNSVLTAVAFCDVITMTSysiylMRFR-FYETDHGYSYIWLVFLKFHVwssm 124
Cdd:cd14982     7 YSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLT-----LPFRiYYYLNGGWWPFGDFLCRLTG---- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 125 TLHAITLYMGGA-LAFI---RWQALgnIH----SKWLQPRNSWQLFGVVSVVLSIVCLPTLVLHKIyeiESPEIETSTVS 196
Cdd:cd14982    78 LLFYINMYGSILfLTCIsvdRYLAV--VHplksRRLRRKRYAVGVCAGVWILVLVASVPLLLLRST---IAKENNSTTCF 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 197 EVLrlsgqsiPKEVRYSLNFSTYSCAFFKFnlwmlaivlkaIPCALLLWFTIALVVKLRQTdekrnylySKSFRKHVKKT 276
Cdd:cd14982   153 EFL-------SEWLASAAPIVLIALVVGFL-----------IPLLIILVCYSLIIRALRRR--------SKQSQKSVRKR 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 277 tvpdRTTYMLIIMLVVFLVTELP------QGFLALLNGLYTGDVNIYIYKNLSELLDFLSLiNCSVDFLLYCVMSSRYRQ 350
Cdd:cd14982   207 ----KALRMILIVLAVFLVCFLPyhvtriLYLLVRLSFIADCSARNSLYKAYRITLCLASL-NSCLDPLIYYFLSKTFRK 281

                  ..
gi 1831507496 351 TF 352
Cdd:cd14982   282 RL 283
7tmA_GPR142 cd15129
G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G ...
229-351 5.81e-03

G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR142, a vertebrate orphan receptor, is very closely related to GPR139, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating enhancement of glucose-stimulated insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320257 [Multi-domain]  Cd Length: 270  Bit Score: 38.22  E-value: 5.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831507496 229 WMLAIVLKAIPCALLLWFTIALVVKLRQTDEkrnylySKSFRKHVKKTTVpdrttyMLIIMLVVFLVTELPQGFLALLNg 308
Cdd:cd15129   159 WTHCFIIYFIPCTIFLVTNSVIIHKLRRRKG------RSGPQRRSGKTTA------ILLAITTVFAVLWAPRTVVIIYH- 225
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1831507496 309 LYTGDVNIYIYKNLS-ELLDFLSLINCSVDFLLYCVMSSRYRQT 351
Cdd:cd15129   226 LYVSSVNRDWRVHLAlDLANMLAMLNTAVNFFLYCFVSKRFRRT 269
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH