BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  28 DRETLCDMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKW--NGDKFDLELVEDELCQKAFAPFLRFMY 105
Cdd:cd18292     1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWwsESKQSEIELVEDPECAAVFEKFLRYLY 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1831508842 106 SNHVVLHKDNCLPLLVLADKYNVTTLKKVCLDFA 139
Cdd:cd18292    81 TGQISVNLETALPLLMLADKYNVTDLKQLCVDFM 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  28 DRETLCDMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKW--NGDKFDLELVEDELCQKAFAPFLRFMY 105
Cdd:cd18292     1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWwsESKQSEIELVEDPECAAVFEKFLRYLY 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1831508842 106 SNHVVLHKDNCLPLLVLADKYNVTTLKKVCLDFA 139
Cdd:cd18292    81 TGQISVNLETALPLLMLADKYNVTDLKQLCVDFM 114

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  37 KFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDlELVEDELCQKAFAPFLRFMYSNHVVlHKDNC 116
Cdd:pfam00651   3 ELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVS-EITLDDVSPEDFEALLEFMYTGKLI-SEENV 80

                          90       100
                  ....*....|....*....|..
gi 1831508842 117 LPLLVLADKYNVTTLKKVCLDF 138
Cdd:pfam00651  81 DDLLAAADKLQIPSLVDKCEEF 102

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842 156 WFSYATKAYHPSLIKSCMQAIALEFETLLTEEwekDWQELHRDQMIEILKCNNLKVASEFKLWEALQKWI 225
Cdd:cd18493     8 WLQYAKMCGHKELAEACLEFIAWNFEKVLKSP---DWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74

kelch-like protein; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  38 FYNNAQFSDVNM--KVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDelcqkAFAPFLRFMYSNHVVLHKDN 115
Cdd:PHA03098    3 SFELQKFCDESIiiVNGGGIIKVHKIILSSSSEYFKKMFKNNFKENEINLNIDYD-----SFNEVIKYIYTGKINITSNN 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842 116 CLPLLVLADKYNVTTLKKVCLDFaqseILPVIDLK---ELFSVWFSYATKAyhpsLIKSCMQAIALEFETLLTEEwekDW 192
Cdd:PHA03098   78 VKDILSIANYLIIDFLINLCINY----IIKIIDDNnciDIYRFSFFYGCKK----LYSAAYNYIRNNIELIYNDP---DF 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842 193 QELHRDQMIEILKCNNLKVASEFKLWEALQKWIQAPNHSERRGntagplLAFLLPLIRFPFMNGDELNEVEKSAISEMHP 272
Cdd:PHA03098  147 IYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKD------ICLILKVLRITFLSEEGIKKLKRWKLRIKKK 220

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1831508842 273 KLFqpplllsykFNALPLSSRMSCKDFTKKQFLL 306
Cdd:PHA03098  221 KIV---------FNKRCIKIIYSKKYNLNKILPR 245

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  28 DRETLCDMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKW--NGDKFDLELVEDELCQKAFAPFLRFMY 105
Cdd:cd18292     1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWwsESKQSEIELVEDPECAAVFEKFLRYLY 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1831508842 106 SNHVVLHKDNCLPLLVLADKYNVTTLKKVCLDFA 139
Cdd:cd18292    81 TGQISVNLETALPLLMLADKYNVTDLKQLCVDFM 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  44 FSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKW---NGDKFDLELVEDElcqkAFAPFLRFMYSNHVVLHKDNCLPLL 120
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMkesSSSEIELDDVSPE----AFEALLDYIYTGELELSEENVEELL 76

                  ....*.
gi 1831508842 121 VLADKY 126
Cdd:cd18186    77 AAADKL 82

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842   46 DVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDeLCQKAFAPFLRFMYSNHVVLHKDNCLPLLVLADK 125
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD-VSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|...
gi 1831508842  126 YNVTTLKKVCLDF 138
Cdd:smart00225  80 LQIPGLVELCEEF 92

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  37 KFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDlELVEDELCQKAFAPFLRFMYSNHVVlHKDNC 116
Cdd:pfam00651   3 ELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVS-EITLDDVSPEDFEALLEFMYTGKLI-SEENV 80

                          90       100
                  ....*....|....*....|..
gi 1831508842 117 LPLLVLADKYNVTTLKKVCLDF 138
Cdd:pfam00651  81 DDLLAAADKLQIPSLVDKCEEF 102

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842 156 WFSYATKAYHPSLIKSCMQAIALEFETLLTEEwekDWQELHRDQMIEILKCNNLKVASEFKLWEALQKWI 225
Cdd:cd18493     8 WLQYAKMCGHKELAEACLEFIAWNFEKVLKSP---DWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  39 YNNAQFSDVNMKVG----EESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDElcQKAFAPFLRFMYSNHVVLHKD 114
Cdd:cd18349     3 FNNELMADVHFIVGppgaSQRVPAHKYVLAVGSSVFYAMFYGDLAEVKSEIHIPDVE--PAAFLILLKYMYSDEIDLEAD 80

                          90       100
                  ....*....|....*....|....*....
gi 1831508842 115 NCLPLLVLADKYNVTTLKKVCLDFAQSEI 143
Cdd:cd18349    81 TVLATLYAAKKYIVPALAKACVNFLETSL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  32 LCDMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMS---QKWNGDKFDLELVEDELcqkaFAPFLRFMYSNH 108
Cdd:cd18256     8 LAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAggmSESSKDVVQIHGVEPDI----FHILLDFIYTGV 83

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1831508842 109 VVLHKDNCLPLLVLADKYNVTTLKKVCLDFAQSEILP 145
Cdd:cd18256    84 VEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHP 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  41 NAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDK---FDLELVEDELCQKafapFLRFMYSNHVVLHKDNCL 117
Cdd:cd18240    14 EGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEkkvYKIPGVSPEMMEL----IIEYAYTRTVPITAENVE 89

                          90       100
                  ....*....|....*....|....*...
gi 1831508842 118 PLLVLADKYNVTTLKKVCLDFAQSEILP 145
Cdd:cd18240    90 ELLPAADQFNIMGIVKACCDFLEDQLCP 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  36 AKFYNNAQFSDVNMKVGE----ESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDElcQKAFAPFLRFMYSNHVVL 111
Cdd:cd18347    14 AFLFNNEVLSDVHFLVGKglgsQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVE--PAAFLALLKFLYSDEVQI 91

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1831508842 112 HKDNCLPLLVLADKYNVTTLKKVCLDFAQSEI 143
Cdd:cd18347    92 GPETVMTTLYTAKKYAVPALEAHCVEFLKKNL 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  46 DVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDkFDLELVEdELCQKAFAPFLRFMYSNHVVLHKDNCLPLLVLADK 125
Cdd:cd18955     3 DVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQTDGD-LVITLPE-EVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAEF 80

                          90
                  ....*....|...
gi 1831508842 126 YNVTTLKKVCLDF 138
Cdd:cd18955    81 LGVHNIEKACFDF 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  44 FSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDeLCQKAFAPFLRFMYSNHVVLHKDNCLPLLVLA 123
Cdd:cd18265    23 FTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQK-VSAAAMEVLLDYMYGGGLRIQEDNVESVLEAS 101

                          90       100
                  ....*....|....*....|..
gi 1831508842 124 DKYNVTTLKKVCLDFAQSEILP 145
Cdd:cd18265   102 DLLQVSKLREACVRFLEGQLHP 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  35 MAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRM----MSQKwngDKFDLELveDELCQKAFAPFLRFMYSNHVV 110
Cdd:cd18242    12 MNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMftseMSEK---GKSEVEL--QGLTASTMEILLDFVYTETVH 86

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1831508842 111 LHKDNCLPLLVLADKYNVTTLKKVCLDFAQSEILP 145
Cdd:cd18242    87 VTVENVQELLPAACLLQLKGVKQACCEFLESQLDP 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  34 DMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDeLCQKAFAPFLRFMYSNHVVLHK 113
Cdd:cd18345     8 DLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITD-VDHEVMREMLRFIYTGKAPNLD 86

                          90       100
                  ....*....|....*....|..
gi 1831508842 114 DNCLPLLVLADKYNVTTLKKVC 135
Cdd:cd18345    87 KMADDLLAAADKYALERLKVMC 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  34 DMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDK---FDLELVEDELcqkaFAPFLRFMYSN--- 107
Cdd:cd18343    11 DLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKknrVEINDVDPEV----FKEMMRFIYTGkap 86

                          90       100
                  ....*....|....*....|....*...
gi 1831508842 108 HVVLHKDNclpLLVLADKYNVTTLKKVC 135
Cdd:cd18343    87 NLDKMADN---LLAAADKYALERLKVMC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  40 NNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKfDLELVEDELCQKAFAPFLRFMYSNHVVLHKDNCLPL 119
Cdd:cd18341    23 DENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEK-KKEVVLDNVDPNIMDMILKYLYSAEIDLNDGNVQDI 101

                          90       100
                  ....*....|....*....|....*.
gi 1831508842 120 LVLADKYNVTTLKKVCLDFAQSEILP 145
Cdd:cd18341   102 FALASRFQIPSVFTVCVTYLQKRLSP 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  43 QFSDVNMKVGEESYPAHRLILSKSSDVFDRMMS---QKWNGDKFDLELVEDELCQKafapFLRFMYSNHVVLHKDNCLPL 119
Cdd:cd18250    20 KFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAgelRESRADRVVLHGVSAEILGL----LLDFSYTGRVTVTQDNVEAL 95

                          90       100
                  ....*....|....*....|....
gi 1831508842 120 LVLADKYNVTTLKKVCLDFAQSEI 143
Cdd:cd18250    96 LRAADLFQFPSVKEACCAYLQQRL 119

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  37 KFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSqkwnGDKFDLELVEDELCQKAFAPFLRFM---YSNHV-VLH 112
Cdd:cd18300     2 LFLNKGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFG----GNFRESSAKEVELPGVSKETFLALLeylYTDQApILE 77

                          90       100
                  ....*....|....*....|...
gi 1831508842 113 KDNCLPLLVLADKYNVTTLKKVC 135
Cdd:cd18300    78 DGDCVGLIVLANRLCLPRLVALC 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  44 FSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDELCQKAFAPFLRFMYSNHVVLHKDNCLPLLVLA 123
Cdd:cd18254    22 FTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDSLHPEVLELLLDFAYSSRIIINEENAESLLEAG 101

                          90       100
                  ....*....|....*....|..
gi 1831508842 124 DKYNVTTLKKVCLDFAQSEILP 145
Cdd:cd18254   102 DMLQFHDVRDAAAEFLEKNLYP 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  30 ETLCDMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMS---QKWNGDKFDLELVEDElcqkAFAPFLRFMYS 106
Cdd:cd18336     5 QTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTndvREAKQEEIKMEGVDPD----ALKALVHYAYT 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1831508842 107 NHVVLHKDNCLPLLVLADKYNVTTLKKVCLDFAQSEILP 145
Cdd:cd18336    81 GVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHP 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  35 MAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMmsqkwngdkFDLELVE---DELCQKAFAP-----FLRFMYS 106
Cdd:cd18247    10 MEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAM---------FTHDMVEskqDEITMQGIEPsaleaLINFAYS 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1831508842 107 NHVVLHKDNCLPLLVLADKYNVTTLKKVCLDF 138
Cdd:cd18247    81 GRIAIDTSNVQSLLVGASFLQLQSVKDACCEF 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  37 KFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSqkwNGDKFDLE-LVE-DELCQKAFAPFLRFMYSNHVVLHKD 114
Cdd:cd18253    11 EFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFC---NDHRESREmLVEiNGILAEAMDCFLQYVYTGKVKITTE 87

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1831508842 115 NCLPLLVLADKYNVTTLKKVCLDFAQSEILP 145
Cdd:cd18253    88 NVQYLFETSSLFQISPLRDACAKFLEEQLDP 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  29 RETLCDMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSS----DVFDRMMSQKWNGDKfdLELVEDELCQKAFAPFLRFM 104
Cdd:cd18258     2 KEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSlyfkDLIKRSSRDSGGGEK--LELTMSNINADVLELLLEFV 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1831508842 105 YSNHVVLHKDNCLPLLVLADKYNVTTLKKVCLDFAQSEI 143
Cdd:cd18258    80 YTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQL 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  46 DVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEdelcQKAFAPFLRFMYSNHVVLHKDNCLPLLVLADK 125
Cdd:cd18218    20 DTLITVGSQEFPAHSLVLAGASQQLGRQLTNPNPGQWCLGEGIS----PSTFKQLLDFVYGESVEVQPGELRPLLEAARA 95

                          90
                  ....*....|.
gi 1831508842 126 YNVTTLKKVCL 136
Cdd:cd18218    96 LEVESLEEACW 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831508842  46 DVNMKVGEESYPAHRLILSKSSDVF-DRMMSQKwngdkfDLEL---VEDELCQKAFAPFLRFMYSNHVVLHKDNCLPLLV 121
Cdd:cd18277    29 DVTILVEGQRFRAHRSVLAACSSYFhSRIVGQA------DAELnitLPEEVTVKGFEPLIQFAYTAKLILSKDNVDEVCK 102

                          90
                  ....*....|....*..
gi 1831508842 122 LADKYNVTTLKKVCLDF 138
Cdd:cd18277   103 CVEFLSVHNIEESCFQF 119