NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1831518343|ref|NP_001368706|]
View 

Kelch domain-containing protein 3 [Caenorhabditis elegans]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 11459646)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
20-338 4.28e-38

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 139.14  E-value: 4.28e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343  20 RVNHASIAVGSRIYSFGGYCSGEVTDakdplDVHVLNTENYRWIKMNPgyvynnriitkatiespysdsdkmfgaVPYQR 99
Cdd:COG3055    13 RSEAAAALLDGKVYVAGGLSGGSASN-----SFEVYDPATNTWSELAP---------------------------LPGPP 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343 100 YGHTV-VEYQGKAYVWGGRNDDYGACNLL---HEYDPEYNVWKKVeieGFVPPSRDGHTAVVWNNQMFVFGGYeeDAQRF 175
Cdd:COG3055    61 RHHAAaVAQDGKLYVFGGFTGANPSSTPLndvYVYDPATNTWTKL---APMPTPRGGATALLLDGKIYVVGGW--DDGGN 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343 176 SQETYVFDFATSTWRemhTKNDPPRWRDFHTASVI-DGMMYIFGGRSDESGqvgdehlfhtihdqyddtlmalnlaTGAW 254
Cdd:COG3055   136 VAWVEVYDPATGTWT---QLAPLPTPRDHLAAAVLpDGKILVIGGRNGSGF-------------------------SNTW 187

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343 255 TRTKVPentmkPGGRRSHSTWVYDGKMYMFGGYLGTinvhYNELYCFDPKTSMWSVIsvrGTYPSARRRHCSVVSNGKVY 334
Cdd:COG3055   188 TTLAPL-----PTARAGHAAAVLGGKILVFGGESGF----SDEVEAYDPATNTWTAL---GELPTPRHGHAAVLTDGKVY 255


                  ....
gi 1831518343 335 LFGG 338
Cdd:COG3055   256 VIGG 259
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
20-338 4.28e-38

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 139.14  E-value: 4.28e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343  20 RVNHASIAVGSRIYSFGGYCSGEVTDakdplDVHVLNTENYRWIKMNPgyvynnriitkatiespysdsdkmfgaVPYQR 99
Cdd:COG3055    13 RSEAAAALLDGKVYVAGGLSGGSASN-----SFEVYDPATNTWSELAP---------------------------LPGPP 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343 100 YGHTV-VEYQGKAYVWGGRNDDYGACNLL---HEYDPEYNVWKKVeieGFVPPSRDGHTAVVWNNQMFVFGGYeeDAQRF 175
Cdd:COG3055    61 RHHAAaVAQDGKLYVFGGFTGANPSSTPLndvYVYDPATNTWTKL---APMPTPRGGATALLLDGKIYVVGGW--DDGGN 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343 176 SQETYVFDFATSTWRemhTKNDPPRWRDFHTASVI-DGMMYIFGGRSDESGqvgdehlfhtihdqyddtlmalnlaTGAW 254
Cdd:COG3055   136 VAWVEVYDPATGTWT---QLAPLPTPRDHLAAAVLpDGKILVIGGRNGSGF-------------------------SNTW 187

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343 255 TRTKVPentmkPGGRRSHSTWVYDGKMYMFGGYLGTinvhYNELYCFDPKTSMWSVIsvrGTYPSARRRHCSVVSNGKVY 334
Cdd:COG3055   188 TTLAPL-----PTARAGHAAAVLGGKILVFGGESGF----SDEVEAYDPATNTWTAL---GELPTPRHGHAAVLTDGKVY 255


                  ....
gi 1831518343 335 LFGG 338
Cdd:COG3055   256 VIGG 259
PLN02153 PLN02153
epithiospecifier protein
 79-338 2.99e-14

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 73.48  E-value: 2.99e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343  79 ATIESPYSDSDKMFGAVPYQRYGHTVVEYQGKAYVWGGRNDDYGACNL-LHEYDPEYNVWKKVEIEGFVPP-SRDGHTAV 156
Cdd:PLN02153    3 PTLQGGWIKVEQKGGKGPGPRCSHGIAVVGDKLYSFGGELKPNEHIDKdLYVFDFNTHTWSIAPANGDVPRiSCLGVRMV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343 157 VWNNQMFVFGGyeEDAQRFSQETYVFDFATSTWREMhTKNDP---PRWRDFHTASVIDGMMYIFGGRSdESGQVGDEHLF 233
Cdd:PLN02153   83 AVGTKLYIFGG--RDEKREFSDFYSYDTVKNEWTFL-TKLDEeggPEARTFHSMASDENHVYVFGGVS-KGGLMKTPERF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343 234 HTIHdqyddtlmALNLATGAWTRTKVP-ENTMKPGGRrshSTWVYDGKMYMFGGYLGTI------NVHYNELYCFDPKTS 306
Cdd:PLN02153  159 RTIE--------AYNIADGKWVQLPDPgENFEKRGGA---GFAVVQGKIWVVYGFATSIlpggksDYESNAVQFFDPASG 227

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1831518343 307 MWSVISVRGTYPSARRRHCSVVSNGKVYLFGG 338
Cdd:PLN02153  228 KWTEVETTGAKPSARSVFAHAVVGKYIIIFGG 259
Kelch_3 pfam13415
Galactose oxidase, central domain;
159-210 3.24e-08

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 49.60  E-value: 3.24e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1831518343 159 NNQMFVFGGYEEDAQRFSQETYVFDFATSTWREmhTKNDPPRwRDFHTASVI 210
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQ--IGDLPPP-RSGHSATYI 49
muta_rot_YjhT TIGR03547
mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...
 109-171 3.14e-03

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.


Pssm-ID: 274641 [Multi-domain]  Cd Length: 346  Bit Score: 39.62  E-value: 3.14e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831518343 109 GKAYVWGG--RNDDYGACNLL---HEYDPEYNVWKKVEIEgfVPPSRDGHTAVVWNN-QMFVFGGYEED 171
Cdd:TIGR03547  64 GKLYVFGGigKANSEGSPQVFddvYRYDPKKNSWQKLDTR--SPVGLLGASGFSLHNgQAYFTGGVNKN 130
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
20-338 4.28e-38

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 139.14  E-value: 4.28e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343  20 RVNHASIAVGSRIYSFGGYCSGEVTDakdplDVHVLNTENYRWIKMNPgyvynnriitkatiespysdsdkmfgaVPYQR 99
Cdd:COG3055    13 RSEAAAALLDGKVYVAGGLSGGSASN-----SFEVYDPATNTWSELAP---------------------------LPGPP 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343 100 YGHTV-VEYQGKAYVWGGRNDDYGACNLL---HEYDPEYNVWKKVeieGFVPPSRDGHTAVVWNNQMFVFGGYeeDAQRF 175
Cdd:COG3055    61 RHHAAaVAQDGKLYVFGGFTGANPSSTPLndvYVYDPATNTWTKL---APMPTPRGGATALLLDGKIYVVGGW--DDGGN 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343 176 SQETYVFDFATSTWRemhTKNDPPRWRDFHTASVI-DGMMYIFGGRSDESGqvgdehlfhtihdqyddtlmalnlaTGAW 254
Cdd:COG3055   136 VAWVEVYDPATGTWT---QLAPLPTPRDHLAAAVLpDGKILVIGGRNGSGF-------------------------SNTW 187

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343 255 TRTKVPentmkPGGRRSHSTWVYDGKMYMFGGYLGTinvhYNELYCFDPKTSMWSVIsvrGTYPSARRRHCSVVSNGKVY 334
Cdd:COG3055   188 TTLAPL-----PTARAGHAAAVLGGKILVFGGESGF----SDEVEAYDPATNTWTAL---GELPTPRHGHAAVLTDGKVY 255


                  ....
gi 1831518343 335 LFGG 338
Cdd:COG3055   256 VIGG 259
PLN02153 PLN02153
epithiospecifier protein
 79-338 2.99e-14

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 73.48  E-value: 2.99e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343  79 ATIESPYSDSDKMFGAVPYQRYGHTVVEYQGKAYVWGGRNDDYGACNL-LHEYDPEYNVWKKVEIEGFVPP-SRDGHTAV 156
Cdd:PLN02153    3 PTLQGGWIKVEQKGGKGPGPRCSHGIAVVGDKLYSFGGELKPNEHIDKdLYVFDFNTHTWSIAPANGDVPRiSCLGVRMV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343 157 VWNNQMFVFGGyeEDAQRFSQETYVFDFATSTWREMhTKNDP---PRWRDFHTASVIDGMMYIFGGRSdESGQVGDEHLF 233
Cdd:PLN02153   83 AVGTKLYIFGG--RDEKREFSDFYSYDTVKNEWTFL-TKLDEeggPEARTFHSMASDENHVYVFGGVS-KGGLMKTPERF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343 234 HTIHdqyddtlmALNLATGAWTRTKVP-ENTMKPGGRrshSTWVYDGKMYMFGGYLGTI------NVHYNELYCFDPKTS 306
Cdd:PLN02153  159 RTIE--------AYNIADGKWVQLPDPgENFEKRGGA---GFAVVQGKIWVVYGFATSIlpggksDYESNAVQFFDPASG 227

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1831518343 307 MWSVISVRGTYPSARRRHCSVVSNGKVYLFGG 338
Cdd:PLN02153  228 KWTEVETTGAKPSARSVFAHAVVGKYIIIFGG 259
PLN02193 PLN02193
nitrile-specifier protein
 93-342 2.24e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 68.44  E-value: 2.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343  93 GAVPYQRYGHTVVEYQGKAYVWGGR-NDDYGACNLLHEYDPEYNVWKKVEIEGFVPP-SRDGHTAVVWNNQMFVFGGyeE 170
Cdd:PLN02193  160 GEGPGLRCSHGIAQVGNKIYSFGGEfTPNQPIDKHLYVFDLETRTWSISPATGDVPHlSCLGVRMVSIGSTLYVFGG--R 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343 171 DAQRFSQETYVFDFATSTWREMHTKNDPPRWRDFHTASVIDGMMYIFGGRSdesgqvGDEHLfhtihdqydDTLMALNLA 250
Cdd:PLN02193  238 DASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVS------ATARL---------KTLDSYNIV 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343 251 TGAWTRTKVPENTMKpgGRRSHSTWVYDGKMYMFGGYLGtinVHYNELYCFDPKTSMWSVISVRGTYPSARRRHCSVVSN 330
Cdd:PLN02193  303 DKKWFHCSTPGDSFS--IRGGAGLEVVQGKVWVVYGFNG---CEVDDVHYYDPVQDKWTQVETFGVRPSERSVFASAAVG 377

                         250
                  ....*....|..
gi 1831518343 331 GKVYLFGGTMPL 342
Cdd:PLN02193  378 KHIVIFGGEIAM 389
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
9-219 4.39e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 66.33  E-value: 4.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343   9 TWTVHLEGGPRRVNHASIAVGSRIYSFGGYcsgevTDAKDPLDVHVLNTENYRWIKMNPgyvynnriitkatiespysds 88
Cdd:COG3055   101 TWTKLAPMPTPRGGATALLLDGKIYVVGGW-----DDGGNVAWVEVYDPATGTWTQLAP--------------------- 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343  89 dkmfgaVPYQRYGHT-VVEYQGKAYVWGGRNDDYGacnllheydpeYNVWKKVEiegFVPPSRDGHTAVVWNNQMFVFGG 167
Cdd:COG3055   155 ------LPTPRDHLAaAVLPDGKILVIGGRNGSGF-----------SNTWTTLA---PLPTARAGHAAAVLGGKILVFGG 214

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1831518343 168 YeedaQRFSQETYVFDFATSTWREMhtkNDPPRWRDFHTASVIDGMMYIFGG 219
Cdd:COG3055   215 E----SGFSDEVEAYDPATNTWTAL---GELPTPRHGHAAVLTDGKVYVIGG 259
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
266-338 4.76e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 57.09  E-value: 4.76e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1831518343 266 PGGRRSHSTWVYDGKMYMFGGYLGTinVHYNELYCFDPKTSMWSVIsvrGTYPSARRRH-CSVVSNGKVYLFGG 338
Cdd:COG3055    10 PTPRSEAAAALLDGKVYVAGGLSGG--SASNSFEVYDPATNTWSEL---APLPGPPRHHaAAVAQDGKLYVFGG 78
Kelch_3 pfam13415
Galactose oxidase, central domain;
159-210 3.24e-08

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 49.60  E-value: 3.24e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1831518343 159 NNQMFVFGGYEEDAQRFSQETYVFDFATSTWREmhTKNDPPRwRDFHTASVI 210
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQ--IGDLPPP-RSGHSATYI 49
PHA03098 PHA03098
kelch-like protein; Provisional
 6-340 1.38e-07

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 53.62  E-value: 1.38e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343   6 KMATWTVHLEGGPRRVNHASIavgSRIYSFGGYCSGEVTDAkDPLDVHVLNTENYRWIKMNPGYVYNNRIITKATIESPY 85
Cdd:PHA03098  209 KLKRWKLRIKKKKIVFNKRCI---KIIYSKKYNLNKILPRS-STFGSIIYIHITMSIFTYNYITNYSPLSEINTIIDIHY 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343  86 SDSdkmFGAVPYqrygHTVVeyqgkaYVWGGRNDDYGACNLLHEYDPEYNVWKKVeiegfvpPS----RDGHTAVVWNNQ 161
Cdd:PHA03098  285 VYC---FGSVVL----NNVI------YFIGGMNKNNLSVNSVVSYDTKTKSWNKV-------PEliypRKNPGVTVFNNR 344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343 162 MFVFGGYEEDAQRFSQETYvfDFATSTWREMHTKNDPprwRDFHTASVIDGMMYIFGGRSDesgqvgdehlfhtiHDQYD 241
Cdd:PHA03098  345 IYVIGGIYNSISLNTVESW--KPGESKWREEPPLIFP---RYNPCVVNVNNLIYVIGGISK--------------NDELL 405

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343 242 DTLMALNLATGAWTrtkvpentMKPGGRRSH---STWVYDGKMYMFGGYLGTINVH-YNELYCFDPKTSMWSVISVRgTY 317
Cdd:PHA03098  406 KTVECFSLNTNKWS--------KGSPLPISHyggCAIYHDGKIYVIGGISYIDNIKvYNIVESYNPVTNKWTELSSL-NF 476

                         330       340
                  ....*....|....*....|...
gi 1831518343 318 PSARRRHCSVvsNGKVYLFGGTM 340
Cdd:PHA03098  477 PRINASLCIF--NNKIYVVGGDK 497
PRK14131 PRK14131
N-acetylneuraminate epimerase;
137-219 2.33e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 49.24  E-value: 2.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343 137 WKKveIEGFVPPSRDGHTAVVWNNQMFVFGG---YEEDAQ-RFSQETYVFDFATSTWREMHTKndPPRWRDFHTASVIDG 212
Cdd:PRK14131   64 WTK--IAAFPGGPREQAVAAFIDGKLYVFGGigkTNSEGSpQVFDDVYKYDPKTNSWQKLDTR--SPVGLAGHVAVSLHN 139


                  ....*...
gi 1831518343 213 -MMYIFGG 219
Cdd:PRK14131  140 gKAYITGG 147
Kelch_4 pfam13418
Galactose oxidase, central domain;
150-195 3.05e-06

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 44.14  E-value: 3.05e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1831518343 150 RDGHTAVVWNNQM-FVFGGYEEDAQRFSqETYVFDFATSTWREMHTK 195
Cdd:pfam13418   2 RAYHTSTSIPDDTiYLFGGEGEDGTLLS-DLWVFDLSTNEWTRLGSL 47
PHA03098 PHA03098
kelch-like protein; Provisional
 16-224 4.13e-06

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 49.00  E-value: 4.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343  16 GGPRRVNHASIAVGSRIYSFGGYCSGEVTDAkdplDVHVLNTENYRWIKM--------NPGYVY-NNRI---------IT 77
Cdd:PHA03098  281 DIHYVYCFGSVVLNNVIYFIGGMNKNNLSVN----SVVSYDTKTKSWNKVpeliyprkNPGVTVfNNRIyviggiynsIS 356

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343  78 KATIESPYSDSDKMFGAVP--YQRYGHTVVEYQGKAYVWGGRNDDYGACNLLHEYDPEYNVWKKVEIegfVPPSRDGHTA 155
Cdd:PHA03098  357 LNTVESWKPGESKWREEPPliFPRYNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSP---LPISHYGGCA 433

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1831518343 156 VVWNNQMFVFGG--YEEDAQRFSQeTYVFDFATSTWREMHTKNDPprwRDFHTASVIDGMMYIFGGRSDES 224
Cdd:PHA03098  434 IYHDGKIYVIGGisYIDNIKVYNI-VESYNPVTNKWTELSSLNFP---RINASLCIFNNKIYVVGGDKYEY 500
Kelch_3 pfam13415
Galactose oxidase, central domain;
278-328 6.26e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 40.35  E-value: 6.26e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1831518343 278 DGKMYMFGGYLGTINVHYNELYCFDPKTSMWSVIsvrGTYPSARRRHCSVV 328
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSATY 48
PHA03098 PHA03098
kelch-like protein; Provisional
 70-330 7.35e-05

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 45.14  E-value: 7.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343  70 VYNNRI-ITKATIESPYSDSD--------KMFGAVP---YQRYGHTVVEYQGKAYVWGGRNDDyGACNLLHEYDPEYNVW 137
Cdd:PHA03098  292 VLNNVIyFIGGMNKNNLSVNSvvsydtktKSWNKVPeliYPRKNPGVTVFNNRIYVIGGIYNS-ISLNTVESWKPGESKW 370

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343 138 KKvEIEGFVPpsRDGHTAVVWNNQMFVFGG-YEEDAQRFSQEtyVFDFATSTWRemhTKNDPPRWRDFHTASVIDGMMYI 216
Cdd:PHA03098  371 RE-EPPLIFP--RYNPCVVNVNNLIYVIGGiSKNDELLKTVE--CFSLNTNKWS---KGSPLPISHYGGCAIYHDGKIYV 442

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343 217 FGGRSDESgqvgDEHLFhTIHDQYddtlmalNLATGAWTRTKVPENTmkpggRRSHSTWVYDGKMYMFGGYlgTINVHYN 296
Cdd:PHA03098  443 IGGISYID----NIKVY-NIVESY-------NPVTNKWTELSSLNFP-----RINASLCIFNNKIYVVGGD--KYEYYIN 503

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1831518343 297 ELYCFDPKTSMWSVIsvrgtypsarRRHCSVVSN 330
Cdd:PHA03098  504 EIEVYDDKTNTWTLF----------CKFPKVIGS 527
PRK14131 PRK14131
N-acetylneuraminate epimerase;
266-338 1.14e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 44.24  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831518343 266 PGGRRSHSTWVY-DGKMYMFGGyLGTIN-----VHYNELYCFDPKTSMWSVISVRGtyPSARRRHCSVVSNG-KVYLFGG 338
Cdd:PRK14131   71 PGGPREQAVAAFiDGKLYVFGG-IGKTNsegspQVFDDVYKYDPKTNSWQKLDTRS--PVGLAGHVAVSLHNgKAYITGG 147
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 150-192 1.94e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.75  E-value: 1.94e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1831518343 150 RDGHTAVVWNNQMFVFGGYeeDAQRFSQETYVFDFATSTWREM 192
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGF--DGNQSLNSVEVYDPETNTWSKL 42
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 19-67 6.44e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 37.32  E-value: 6.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1831518343  19 RRVNHASIAVGSRIYSFGGYCSGevtDAKDPLDVHVLNTENYRWIKMNP 67
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGL---GDLSSSDVLVYDPETNVWTEVPR 46
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 266-305 1.19e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 36.39  E-value: 1.19e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1831518343 266 PGGRRSHSTWVYDGKMYMFGGYLGTINVHYNELYCFDPKT 305
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEGQPSDDVYVLSLPT 40
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 150-192 1.42e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 36.55  E-value: 1.42e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1831518343 150 RDGHTAVVWNNQMFVFGGYEEDAQRFSQETYVFDFATSTWREM 192
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLGDLSSSDVLVYDPETNVWTEV 44
Kelch_6 pfam13964
Kelch motif;
269-312 2.39e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.77  E-value: 2.39e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1831518343 269 RRSHSTWVYDGKMYMFGGYlGTINVHYNELYCFDPKTSMWSVIS 312
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGY-TNASPALNKLEVYNPLTKSWEELP 44
Kelch_4 pfam13418
Galactose oxidase, central domain;
99-140 2.73e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.67  E-value: 2.73e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1831518343  99 RYGHTVVE-YQGKAYVWGGRNDDYGACNLLHEYDPEYNVWKKV 140
Cdd:pfam13418   2 RAYHTSTSiPDDTIYLFGGEGEDGTLLSDLWVFDLSTNEWTRL 44
muta_rot_YjhT TIGR03547
mutatrotase, YjhT family; Members of this protein family contain multiple copies of the ...
 109-171 3.14e-03

mutatrotase, YjhT family; Members of this protein family contain multiple copies of the beta-propeller-forming Kelch repeat. All are full-length homologs to YjhT of Escherichia coli, which has been identified as a mutarotase for sialic acid. This protein improves bacterial ability to obtain host sialic acid, and thus serves as a virulence factor. Some bacteria carry what appears to be a cyclically permuted homolog of this protein.


Pssm-ID: 274641 [Multi-domain]  Cd Length: 346  Bit Score: 39.62  E-value: 3.14e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831518343 109 GKAYVWGG--RNDDYGACNLL---HEYDPEYNVWKKVEIEgfVPPSRDGHTAVVWNN-QMFVFGGYEED 171
Cdd:TIGR03547  64 GKLYVFGGigKANSEGSPQVFddvYRYDPKKNSWQKLDTR--SPVGLLGASGFSLHNgQAYFTGGVNKN 130
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 99-140 3.65e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 35.39  E-value: 3.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1831518343  99 RYGHTVVEYQGKAYVWGGRNDDYG-ACNLLHEYDPEYNVWKKV 140
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLGDlSSSDVLVYDPETNVWTEV 44
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 19-67 4.64e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 34.90  E-value: 4.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1831518343  19 RRVNHASIAVGSRIYSFGGYCSGEVTDakdplDVHVLNTENYRWIKMNP 67
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLN-----SVEVYDPETNTWSKLPS 44
PRK14131 PRK14131
N-acetylneuraminate epimerase;
109-170 5.32e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 38.84  E-value: 5.32e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1831518343 109 GKAYVWGG--RNDDYGACNLL---HEYDPEYNVWKKVEIEGfvPPSRDGHTAVVWNN-QMFVFGGYEE 170
Cdd:PRK14131   85 GKLYVFGGigKTNSEGSPQVFddvYKYDPKTNSWQKLDTRS--PVGLAGHVAVSLHNgKAYITGGVNK 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH