|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
257-610 |
1.87e-25 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 109.23 E-value: 1.87e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 257 DPYEKAIASDDLLHLAQVYQDETWTAKRL-------VTGMAFSehyPD---LLAVSYGpcdipneppGVIVVWNTKSKRM 326
Cdd:COG2319 87 SPDGRLLASASADGTVRLWDLATGLLLRTltghtgaVRSVAFS---PDgktLASGSAD---------GTVRLWDLATGKL 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 327 TAEFIVYcQSEIQSVAFARfHAHLLLAGCESGQICVWDnrLTSRKLPinrspLTTQAHTYTVSCLAVvgTKNAHNFVSLS 406
Cdd:COG2319 155 LRTLTGH-SGAVTSVAFSP-DGKLLASGSDDGTVRLWD--LATGKLL-----RTLTGHTGAVRSVAF--SPDGKLLASGS 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 407 RDGRICSWNVDNltqpvdGKELMTKEGKAASATRMSF-PIGemQTFVVGTDTGEIlaasR--NGADPAVIKTdvcYKGHS 483
Cdd:COG2319 224 ADGTVRLWDLAT------GKLLRTLTGHSGSVRSVAFsPDG--RLLASGSADGTV----RlwDLATGELLRT---LTGHS 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 484 GTLTGIEFHRasgvvDfSHLFISSSHDWTVKLWSTKDANLKFSFESHPDLVLDVAWSPVHPAVfASIDADGNIFVWNLNE 563
Cdd:COG2319 289 GGVNSVAFSP-----D-GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLAT 361
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1845975681 564 dvEGPVARLRagaeGESVYMNRLIWSPDGKHVFVGDDEGRVHMYDVR 610
Cdd:COG2319 362 --GELLRTLT----GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
382-611 |
7.80e-21 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 93.17 E-value: 7.80e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 382 QAHTYTVSCLAVVGTKNahNFVSLSRDGRICSWNVDnltqpvDGKELMTKEGkaasatrmsfPIGEMQTFVVGTDTGEIL 461
Cdd:cd00200 6 KGHTGGVTCVAFSPDGK--LLATGSGDGTIKVWDLE------TGELLRTLKG----------HTGPVRDVAASADGTYLA 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 462 AASRNGA-------DPAVIKTdvcYKGHSGTLTGIEFHRASgvvdfsHLFISSSHDWTVKLWSTKDANLKFSFESHPDLV 534
Cdd:cd00200 68 SGSSDKTirlwdleTGECVRT---LTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWV 138
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1845975681 535 LDVAWSPVHPAVFASiDADGNIFVWNLNEdvEGPVARLragaEGESVYMNRLIWSPDGKHVFVGDDEGRVHMYDVRE 611
Cdd:cd00200 139 NSVAFSPDGTFVASS-SQDGTIKLWDLRT--GKCVATL----TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
522-560 |
1.67e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 36.52 E-value: 1.67e-03
10 20 30
....*....|....*....|....*....|....*....
gi 1845975681 522 NLKFSFESHPDLVLDVAWSPVHPaVFASIDADGNIFVWN 560
Cdd:smart00320 3 ELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
257-610 |
1.87e-25 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 109.23 E-value: 1.87e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 257 DPYEKAIASDDLLHLAQVYQDETWTAKRL-------VTGMAFSehyPD---LLAVSYGpcdipneppGVIVVWNTKSKRM 326
Cdd:COG2319 87 SPDGRLLASASADGTVRLWDLATGLLLRTltghtgaVRSVAFS---PDgktLASGSAD---------GTVRLWDLATGKL 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 327 TAEFIVYcQSEIQSVAFARfHAHLLLAGCESGQICVWDnrLTSRKLPinrspLTTQAHTYTVSCLAVvgTKNAHNFVSLS 406
Cdd:COG2319 155 LRTLTGH-SGAVTSVAFSP-DGKLLASGSDDGTVRLWD--LATGKLL-----RTLTGHTGAVRSVAF--SPDGKLLASGS 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 407 RDGRICSWNVDNltqpvdGKELMTKEGKAASATRMSF-PIGemQTFVVGTDTGEIlaasR--NGADPAVIKTdvcYKGHS 483
Cdd:COG2319 224 ADGTVRLWDLAT------GKLLRTLTGHSGSVRSVAFsPDG--RLLASGSADGTV----RlwDLATGELLRT---LTGHS 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 484 GTLTGIEFHRasgvvDfSHLFISSSHDWTVKLWSTKDANLKFSFESHPDLVLDVAWSPVHPAVfASIDADGNIFVWNLNE 563
Cdd:COG2319 289 GGVNSVAFSP-----D-GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLAT 361
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1845975681 564 dvEGPVARLRagaeGESVYMNRLIWSPDGKHVFVGDDEGRVHMYDVR 610
Cdd:COG2319 362 --GELLRTLT----GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
336-629 |
2.26e-23 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 103.07 E-value: 2.26e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 336 SEIQSVAFARfHAHLLLAGCESGQICVWDnrltsrkLPINRSPLTTQAHTYTVSCLAVvgTKNAHNFVSLSRDGRICSWN 415
Cdd:COG2319 79 AAVLSVAFSP-DGRLLASASADGTVRLWD-------LATGLLLRTLTGHTGAVRSVAF--SPDGKTLASGSADGTVRLWD 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 416 VDnltqpvDGKELMTKEGKAASATRMSF-PIGemQTFVVGTDTGEIlaasR--NGADPAVIKTdvcYKGHSGTLTGIEFH 492
Cdd:COG2319 149 LA------TGKLLRTLTGHSGAVTSVAFsPDG--KLLASGSDDGTV----RlwDLATGKLLRT---LTGHTGAVRSVAFS 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 493 RasgvvDfSHLFISSSHDWTVKLWSTKDANLKFSFESHPDLVLDVAWSPvHPAVFASIDADGNIFVWNLNedvEGPVARL 572
Cdd:COG2319 214 P-----D-GKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLA---TGELLRT 283
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1845975681 573 RAGAEGEsvyMNRLIWSPDGKHVFVGDDEGRVHMYDV--RESLYVLKSEEWNRFARVLS 629
Cdd:COG2319 284 LTGHSGG---VNSVAFSPDGKLLASGSDDGTVRLWDLatGKLLRTLTGHTGAVRSVAFS 339
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
382-611 |
7.80e-21 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 93.17 E-value: 7.80e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 382 QAHTYTVSCLAVVGTKNahNFVSLSRDGRICSWNVDnltqpvDGKELMTKEGkaasatrmsfPIGEMQTFVVGTDTGEIL 461
Cdd:cd00200 6 KGHTGGVTCVAFSPDGK--LLATGSGDGTIKVWDLE------TGELLRTLKG----------HTGPVRDVAASADGTYLA 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 462 AASRNGA-------DPAVIKTdvcYKGHSGTLTGIEFHRASgvvdfsHLFISSSHDWTVKLWSTKDANLKFSFESHPDLV 534
Cdd:cd00200 68 SGSSDKTirlwdleTGECVRT---LTGHTSYVSSVAFSPDG------RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWV 138
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1845975681 535 LDVAWSPVHPAVFASiDADGNIFVWNLNEdvEGPVARLragaEGESVYMNRLIWSPDGKHVFVGDDEGRVHMYDVRE 611
Cdd:cd00200 139 NSVAFSPDGTFVASS-SQDGTIKLWDLRT--GKCVATL----TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
286-608 |
1.47e-19 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 89.32 E-value: 1.47e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 286 VTGMAFSEHYPDLLAVSYGpcdipneppGVIVVWNTKskrmTAEFIVYCQSEIQSVAFARFHAH--LLLAGCESGQICVW 363
Cdd:cd00200 12 VTCVAFSPDGKLLATGSGD---------GTIKVWDLE----TGELLRTLKGHTGPVRDVAASADgtYLASGSSDKTIRLW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 364 DnrLTSRKLPInrsplTTQAHTYTVSCLAVvgTKNAHNFVSLSRDGRICSWNVDNltqpvdGKELMTKEGKAASATRMSF 443
Cdd:cd00200 79 D--LETGECVR-----TLTGHTSYVSSVAF--SPDGRILSSSSRDKTIKVWDVET------GKCLTTLRGHTDWVNSVAF 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 444 PigEMQTFVVGtdtgeilaASRNGA----DPAVIKTDVCYKGHSGTLTGIEFHRASGvvdfshLFISSSHDWTVKLWSTK 519
Cdd:cd00200 144 S--PDGTFVAS--------SSQDGTiklwDLRTGKCVATLTGHTGEVNSVAFSPDGE------KLLSSSSDGTIKLWDLS 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 520 DANLKFSFESHPDLVLDVAWSPvHPAVFASIDADGNIFVWNLNEDVegPVARLRAGAEgeSVYmnRLIWSPDGKHVFVGD 599
Cdd:cd00200 208 TGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGE--CVQTLSGHTN--SVT--SLAWSPDGKRLASGS 280
|
....*....
gi 1845975681 600 DEGRVHMYD 608
Cdd:cd00200 281 ADGTIRIWD 289
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
336-610 |
9.41e-17 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 81.23 E-value: 9.41e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 336 SEIQSVAFARfHAHLLLAGCESGQICVWDnrltsrkLPINRSPLTTQAHTYTVSCLAVVGtkNAHNFVSLSRDGRICSWN 415
Cdd:cd00200 10 GGVTCVAFSP-DGKLLATGSGDGTIKVWD-------LETGELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 416 VDNltqpvdGKELMTKEGKAASATRMSFpigemqtfvvgTDTGEILAASrnGADPAV----IKTDVC---YKGHSGTLTG 488
Cdd:cd00200 80 LET------GECVRTLTGHTSYVSSVAF-----------SPDGRILSSS--SRDKTIkvwdVETGKClttLRGHTDWVNS 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 489 IEFHRASGVVdfshlfISSSHDWTVKLWSTKDANLKFSFESHPDLVLDVAWSPVHPAVFASIDaDGNIFVWNLNEDVEgp 568
Cdd:cd00200 141 VAFSPDGTFV------ASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTGKC-- 211
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 1845975681 569 VARLRagaeGESVYMNRLIWSPDGKHVFVGDDEGRVHMYDVR 610
Cdd:cd00200 212 LGTLR----GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR 249
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
286-520 |
1.59e-13 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 72.64 E-value: 1.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 286 VTGMAFSehyPD--LLAVSYGPcdipneppGVIVVWNTKSKRMTAEFIVYcQSEIQSVAFARfHAHLLLAGCESGQICVW 363
Cdd:COG2319 207 VRSVAFS---PDgkLLASGSAD--------GTVRLWDLATGKLLRTLTGH-SGSVRSVAFSP-DGRLLASGSADGTVRLW 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 364 DnrLTSRKLPinrspLTTQAHTYTVSCLAVvgTKNAHNFVSLSRDGRICSWNVDnltqpvDGKELMTKEGKAASATRMSF 443
Cdd:COG2319 274 D--LATGELL-----RTLTGHSGGVNSVAF--SPDGKLLASGSDDGTVRLWDLA------TGKLLRTLTGHTGAVRSVAF 338
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1845975681 444 -PIGemQTFVVGTDTGEILAasRNGADPAVIKTdvcYKGHSGTLTGIEFHRASgvvdfsHLFISSSHDWTVKLWSTKD 520
Cdd:COG2319 339 sPDG--KTLASGSDDGTVRL--WDLATGELLRT---LTGHTGAVTSVAFSPDG------RTLASGSADGTVRLWDLAT 403
|
|
| COG4946 |
COG4946 |
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ... |
536-624 |
2.20e-05 |
|
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];
Pssm-ID: 443973 [Multi-domain] Cd Length: 1072 Bit Score: 47.73 E-value: 2.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 536 DVAWSP----VhpaVFASiDADG--NIFVWNLNEdvEGPVARLragAEGESVYMNRLIWSPDGKHVFVGDDEGRVHMYDV 609
Cdd:COG4946 347 LPAWSPdgksI---AYFS-DASGeyELYIAPADG--SGEPKQL---TLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDL 417
|
90 100
....*....|....*....|
gi 1845975681 610 -----REslyVLKSEEWNRF 624
Cdd:COG4946 418 asgkvRK---VDTDGYGDGI 434
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
522-560 |
1.67e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 36.52 E-value: 1.67e-03
10 20 30
....*....|....*....|....*....|....*....
gi 1845975681 522 NLKFSFESHPDLVLDVAWSPVHPaVFASIDADGNIFVWN 560
Cdd:smart00320 3 ELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
523-610 |
4.92e-03 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 39.24 E-value: 4.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845975681 523 LKFSFESHPDLVLDVAWSPVHPaVFASIDADGNIFVWNLNEDVegPVARLragaEGESVYMNRLIWSPDGKHVFVGDDEG 602
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGE--LLRTL----KGHTGPVRDVAASADGTYLASGSSDK 73
|
....*...
gi 1845975681 603 RVHMYDVR 610
Cdd:cd00200 74 TIRLWDLE 81
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
479-517 |
6.78e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 34.60 E-value: 6.78e-03
10 20 30
....*....|....*....|....*....|....*....
gi 1845975681 479 YKGHSGTLTGIEFHrasgvvDFSHLFISSSHDWTVKLWS 517
Cdd:smart00320 8 LKGHTGPVTSVAFS------PDGKYLASGSDDGTIKLWD 40
|
|
| |
