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Conserved domains on  [gi|1845970430|ref|NP_001370607|]
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WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 411-559 2.36e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 103.18  E-value: 2.36e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 411 KQHRGSVYCLSFNPNGDLLATGSNDKTIRLMAFNEDSCRigaeMELTCHDGTVRDLIFiessiNRSTILVSGGAGNCHLN 490
Cdd:cd00200    90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL----TTLRGHTDWVNSVAF-----SPDGTFVASSSQDGTIK 160

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1845970430 491 VTDCNTGQLIQSMKGHTAPILGLyTWSQAGNQFVSCSQDKTIRFWDLRQQTAVnvispGSNKSHSEFFN 559
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSV-AFSPDGEKLLSSSSDGTIKLWDLSTGKCL-----GTLRGHENGVN 223
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 355-440 3.69e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 45.79  E-value: 3.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 355 SQAIRATGFHPSGRYFALGtnSKQLHICLYpDTKRTQSRPMAyeqtknaeiavtrpKQHRGSVYCLSFNPNGDLLATGSN 434
Cdd:cd00200   219 ENGVNSVAFSPDGYLLASG--SEDGTIRVW-DLRTGECVQTL--------------SGHTNSVTSLAWSPDGKRLASGSA 281


                  ....*.
gi 1845970430 435 DKTIRL 440
Cdd:cd00200   282 DGTIRI 287
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 411-559 2.36e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.18  E-value: 2.36e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 411 KQHRGSVYCLSFNPNGDLLATGSNDKTIRLMAFNEDSCRigaeMELTCHDGTVRDLIFiessiNRSTILVSGGAGNCHLN 490
Cdd:cd00200    90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL----TTLRGHTDWVNSVAF-----SPDGTFVASSSQDGTIK 160

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1845970430 491 VTDCNTGQLIQSMKGHTAPILGLyTWSQAGNQFVSCSQDKTIRFWDLRQQTAVnvispGSNKSHSEFFN 559
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSV-AFSPDGEKLLSSSSDGTIKLWDLSTGKCL-----GTLRGHENGVN 223
WD40 COG2319
WD40 repeat [General function prediction only];
355-555 4.96e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.44  E-value: 4.96e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 355 SQAIRATGFHPSGRYFALGTNSKQLHIclypdtkrtqsrpmaYEQTKNAEIAVTRPkqHRGSVYCLSFNPNGDLLATGSN 434
Cdd:COG2319   120 TGAVRSVAFSPDGKTLASGSADGTVRL---------------WDLATGKLLRTLTG--HSGAVTSVAFSPDGKLLASGSD 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 435 DKTIRLmaFNEDSCRIGAemELTCHDGTVRDLIFieSSinRSTILVSGGAGNcHLNVTDCNTGQLIQSMKGHTAPILGLy 514
Cdd:COG2319   183 DGTVRL--WDLATGKLLR--TLTGHTGAVRSVAF--SP--DGKLLASGSADG-TVRLWDLATGKLLRTLTGHSGSVRSV- 252

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1845970430 515 TWSQAGNQFVSCSQDKTIRFWDLRQQTAVNVISPGSNKSHS 555
Cdd:COG2319   253 AFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNS 293
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 496-536 1.11e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 1.11e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1845970430  496 TGQLIQSMKGHTAPILGLyTWSQAGNQFVSCSQDKTIRFWD 536
Cdd:smart00320   1 SGELLKTLKGHTGPVTSV-AFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
497-536 8.44e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 8.44e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1845970430 497 GQLIQSMKGHTAPILGLyTWSQAGNQFVSCSQDKTIRFWD 536
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSL-AFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 355-440 3.69e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.79  E-value: 3.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 355 SQAIRATGFHPSGRYFALGtnSKQLHICLYpDTKRTQSRPMAyeqtknaeiavtrpKQHRGSVYCLSFNPNGDLLATGSN 434
Cdd:cd00200   219 ENGVNSVAFSPDGYLLASG--SEDGTIRVW-DLRTGECVQTL--------------SGHTNSVTSLAWSPDGKRLASGSA 281


                  ....*.
gi 1845970430 435 DKTIRL 440
Cdd:cd00200   282 DGTIRI 287
PTZ00421 PTZ00421
coronin; Provisional
 414-543 7.51e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.27  E-value: 7.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 414 RGSVYCLSFNP-NGDLLATGSNDKTIRLMAFNEDSCRIGAE---MELTCHDGTVRDLIFIESSINrstILVSGGAGNChL 489
Cdd:PTZ00421   75 EGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNISdpiVHLQGHTKKVGIVSFHPSAMN---VLASAGADMV-V 150

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1845970430 490 NVTDCNTGQLIQSMKGHTAPILGLyTWSQAGNQFVSCSQDKTIRFWDLRQQTAV 543
Cdd:PTZ00421  151 NVWDVERGKAVEVIKCHSDQITSL-EWNLDGSLLCTTSKDKKLNIIDPRDGTIV 203
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 411-559 2.36e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.18  E-value: 2.36e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 411 KQHRGSVYCLSFNPNGDLLATGSNDKTIRLMAFNEDSCRigaeMELTCHDGTVRDLIFiessiNRSTILVSGGAGNCHLN 490
Cdd:cd00200    90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL----TTLRGHTDWVNSVAF-----SPDGTFVASSSQDGTIK 160

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1845970430 491 VTDCNTGQLIQSMKGHTAPILGLyTWSQAGNQFVSCSQDKTIRFWDLRQQTAVnvispGSNKSHSEFFN 559
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSV-AFSPDGEKLLSSSSDGTIKLWDLSTGKCL-----GTLRGHENGVN 223
WD40 COG2319
WD40 repeat [General function prediction only];
355-555 4.96e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.44  E-value: 4.96e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 355 SQAIRATGFHPSGRYFALGTNSKQLHIclypdtkrtqsrpmaYEQTKNAEIAVTRPkqHRGSVYCLSFNPNGDLLATGSN 434
Cdd:COG2319   120 TGAVRSVAFSPDGKTLASGSADGTVRL---------------WDLATGKLLRTLTG--HSGAVTSVAFSPDGKLLASGSD 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 435 DKTIRLmaFNEDSCRIGAemELTCHDGTVRDLIFieSSinRSTILVSGGAGNcHLNVTDCNTGQLIQSMKGHTAPILGLy 514
Cdd:COG2319   183 DGTVRL--WDLATGKLLR--TLTGHTGAVRSVAF--SP--DGKLLASGSADG-TVRLWDLATGKLLRTLTGHSGSVRSV- 252

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1845970430 515 TWSQAGNQFVSCSQDKTIRFWDLRQQTAVNVISPGSNKSHS 555
Cdd:COG2319   253 AFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNS 293
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 413-547 5.05e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.25  E-value: 5.05e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 413 HRGSVYCLSFNPNGDLLATGSNDKTIRLMAFNEDSCRigaeMELTCHDGTVRDLIFiesSINRSTILVSGGAGNCHLnvT 492
Cdd:cd00200   134 HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCV----ATLTGHTGEVNSVAF---SPDGEKLLSSSSDGTIKL--W 204

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1845970430 493 DCNTGQLIQSMKGHTAPILGLyTWSQAGNQFVSCSQDKTIRFWDLRQQTAVNVIS 547
Cdd:cd00200   205 DLSTGKCLGTLRGHENGVNSV-AFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS 258
WD40 COG2319
WD40 repeat [General function prediction only];
355-547 7.52e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.06  E-value: 7.52e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 355 SQAIRATGFHPSGRYFALGTNSKQLHIClypDTKRTQsrpmayeqtknaeiAVTRPKQHRGSVYCLSFNPNGDLLATGSN 434
Cdd:COG2319   204 TGAVRSVAFSPDGKLLASGSADGTVRLW---DLATGK--------------LLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 435 DKTIRLmaFNEDSCRIGAEmeLTCHDGTVRDLIFiesSINrSTILVSGGAGNcHLNVTDCNTGQLIQSMKGHTAPILGLy 514
Cdd:COG2319   267 DGTVRL--WDLATGELLRT--LTGHSGGVNSVAF---SPD-GKLLASGSDDG-TVRLWDLATGKLLRTLTGHTGAVRSV- 336

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1845970430 515 TWSQAGNQFVSCSQDKTIRFWDLRQQTAVNVIS 547
Cdd:COG2319   337 AFSPDGKTLASGSDDGTVRLWDLATGELLRTLT 369
WD40 COG2319
WD40 repeat [General function prediction only];
354-538 1.16e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.29  E-value: 1.16e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 354 DSQAIRATGFHPSGRYFALGTNSKQLHIClypDTKRTQsrpmayeqtknaeiAVTRPKQHRGSVYCLSFNPNGDLLATGS 433
Cdd:COG2319   245 HSGSVRSVAFSPDGRLLASGSADGTVRLW---DLATGE--------------LLRTLTGHSGGVNSVAFSPDGKLLASGS 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 434 NDKTIRLMAFNEDSCRIGaemeLTCHDGTVRDLIFieSSINRstILVSGGAGNcHLNVTDCNTGQLIQSMKGHTAPILGL 513
Cdd:COG2319   308 DDGTVRLWDLATGKLLRT----LTGHTGAVRSVAF--SPDGK--TLASGSDDG-TVRLWDLATGELLRTLTGHTGAVTSV 378

                         170       180
                  ....*....|....*....|....*
gi 1845970430 514 yTWSQAGNQFVSCSQDKTIRFWDLR 538
Cdd:COG2319   379 -AFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
407-555 3.23e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.13  E-value: 3.23e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 407 VTRPKQHRGSVYCLSFNPNGDLLATGSNDKTIRLmaFNEDSCRIGAemELTCHDGTVRDLIFiessinrS---TILVSGG 483
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL--WDLATGKLLR--TLTGHSGAVTSVAF-------SpdgKLLASGS 181

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1845970430 484 AGNcHLNVTDCNTGQLIQSMKGHTAPILGLyTWSQAGNQFVSCSQDKTIRFWDLRQQTAVNVISPGSNKSHS 555
Cdd:COG2319   182 DDG-TVRLWDLATGKLLRTLTGHTGAVRSV-AFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRS 251
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 413-536 4.84e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 4.84e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 413 HRGSVYCLSFNPNGDLLATGSNDKTIRLMAFNEDSCrigaEMELTCHDGTVRDLIFiessiNRSTILVSGGAGNCHLNVT 492
Cdd:cd00200   176 HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC----LGTLRGHENGVNSVAF-----SPDGYLLASGSEDGTIRVW 246

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1845970430 493 DCNTGQLIQSMKGHTAPILGLyTWSQAGNQFVSCSQDKTIRFWD 536
Cdd:cd00200   247 DLRTGECVQTLSGHTNSVTSL-AWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
355-555 8.33e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.59  E-value: 8.33e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 355 SQAIRATGFHPSGRYFALGTNSKQLHIclypdtkrtqsrpmaYEQTKNAEIAVTRPkqHRGSVYCLSFNPNGDLLATGSN 434
Cdd:COG2319   162 SGAVTSVAFSPDGKLLASGSDDGTVRL---------------WDLATGKLLRTLTG--HTGAVRSVAFSPDGKLLASGSA 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 435 DKTIRLmaFNEDSCRIGAemELTCHDGTVRDLIFiesSINrSTILVSGGAGNcHLNVTDCNTGQLIQSMKGHTAPILGLy 514
Cdd:COG2319   225 DGTVRL--WDLATGKLLR--TLTGHSGSVRSVAF---SPD-GRLLASGSADG-TVRLWDLATGELLRTLTGHSGGVNSV- 294

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1845970430 515 TWSQAGNQFVSCSQDKTIRFWDLRQQTAVNVISPGSNKSHS 555
Cdd:COG2319   295 AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 335
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 413-539 1.38e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.01  E-value: 1.38e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 413 HRGSVYCLSFNPNGDLLATGSNDKTIRLMAFNEDSCrigaEMELTCHDGTVRDLIFiessINRSTILVSGGAGNChLNVT 492
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGEL----LRTLKGHTGPVRDVAA----SADGTYLASGSSDKT-IRLW 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1845970430 493 DCNTGQLIQSMKGHTAPILGLyTWSQAGNQFVSCSQDKTIRFWDLRQ 539
Cdd:cd00200    79 DLETGECVRTLTGHTSYVSSV-AFSPDGRILSSSSRDKTIKVWDVET 124
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 496-536 1.11e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 1.11e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1845970430  496 TGQLIQSMKGHTAPILGLyTWSQAGNQFVSCSQDKTIRFWD 536
Cdd:smart00320   1 SGELLKTLKGHTGPVTSV-AFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 411-440 7.69e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 7.69e-08
                           10        20        30
                   ....*....|....*....|....*....|
gi 1845970430  411 KQHRGSVYCLSFNPNGDLLATGSNDKTIRL 440
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
497-536 8.44e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 8.44e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1845970430 497 GQLIQSMKGHTAPILGLyTWSQAGNQFVSCSQDKTIRFWD 536
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSL-AFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
411-440 1.21e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 1.21e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 1845970430 411 KQHRGSVYCLSFNPNGDLLATGSNDKTIRL 440
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKV 37
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 355-440 3.69e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.79  E-value: 3.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 355 SQAIRATGFHPSGRYFALGtnSKQLHICLYpDTKRTQSRPMAyeqtknaeiavtrpKQHRGSVYCLSFNPNGDLLATGSN 434
Cdd:cd00200   219 ENGVNSVAFSPDGYLLASG--SEDGTIRVW-DLRTGECVQTL--------------SGHTNSVTSLAWSPDGKRLASGSA 281


                  ....*.
gi 1845970430 435 DKTIRL 440
Cdd:cd00200   282 DGTIRI 287
PTZ00421 PTZ00421
coronin; Provisional
 414-543 7.51e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.27  E-value: 7.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1845970430 414 RGSVYCLSFNP-NGDLLATGSNDKTIRLMAFNEDSCRIGAE---MELTCHDGTVRDLIFIESSINrstILVSGGAGNChL 489
Cdd:PTZ00421   75 EGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNISdpiVHLQGHTKKVGIVSFHPSAMN---VLASAGADMV-V 150

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1845970430 490 NVTDCNTGQLIQSMKGHTAPILGLyTWSQAGNQFVSCSQDKTIRFWDLRQQTAV 543
Cdd:PTZ00421  151 NVWDVERGKAVEVIKCHSDQITSL-EWNLDGSLLCTTSKDKKLNIIDPRDGTIV 203
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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