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Conserved domains on  [gi|1846471307|ref|NP_001371053|]
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uncharacterized protein LOC211135 isoform 1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 19-60 3.84e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.21  E-value: 3.84e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1846471307  19 SVTYDDVHVNFTGEEWVLLDASQKSLYRDVMLETYSNLTAIG 60
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
131-326 6.20e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 6.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471307 131 HSSLSNHEKHHTGEKPYKCIECGKAFSQQSHLQIHKRIHTG-EKPYECNQCAKAFSQQSHLQKHKRT--HTGE--KPYKC 205
Cdd:COG5048   245 PSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSC 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471307 206 --NQCNKDFSQQSHLQIHRRTHTGEKPYKC--NQCDKVFSQ-------QTHLQRHKRTHTGEKPYKCNQCGKAFAHHSYL 274
Cdd:COG5048   325 pySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPllnneppQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNL 404

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1846471307 275 EKHQRTHTGEKPYQCN--QCGKAFAHHSYLQKHKRTHTGEKPYQCNQCGKTFAC 326
Cdd:COG5048   405 SLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
zf-H2C2_2 pfam13465
Zinc-finger double domain;
385-410 4.63e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.63e-04
                          10        20
                  ....*....|....*....|....*.
gi 1846471307 385 HLQRHERVHTGEKPYECSQCGKAFAC 410
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
357-382 1.20e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.20e-03
                          10        20
                  ....*....|....*....|....*.
gi 1846471307 357 YLRNHKRTHTGENPYKCKECGKAFAC 382
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 19-60 3.84e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.21  E-value: 3.84e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1846471307  19 SVTYDDVHVNFTGEEWVLLDASQKSLYRDVMLETYSNLTAIG 60
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
20-62 1.16e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 76.48  E-value: 1.16e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1846471307   20 VTYDDVHVNFTGEEWVLLDASQKSLYRDVMLETYSNLTAIGYK 62
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 20-57 1.14e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.35  E-value: 1.14e-16
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1846471307  20 VTYDDVHVNFTGEEWVLLDASQKSLYRDVMLETYSNLT 57
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
131-326 6.20e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 6.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471307 131 HSSLSNHEKHHTGEKPYKCIECGKAFSQQSHLQIHKRIHTG-EKPYECNQCAKAFSQQSHLQKHKRT--HTGE--KPYKC 205
Cdd:COG5048   245 PSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSC 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471307 206 --NQCNKDFSQQSHLQIHRRTHTGEKPYKC--NQCDKVFSQ-------QTHLQRHKRTHTGEKPYKCNQCGKAFAHHSYL 274
Cdd:COG5048   325 pySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPllnneppQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNL 404

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1846471307 275 EKHQRTHTGEKPYQCN--QCGKAFAHHSYLQKHKRTHTGEKPYQCNQCGKTFAC 326
Cdd:COG5048   405 SLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-270 1.05e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.05e-04
                          10        20
                  ....*....|....*....|....*.
gi 1846471307 245 HLQRHKRTHTGEKPYKCNQCGKAFAH 270
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
385-410 4.63e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.63e-04
                          10        20
                  ....*....|....*....|....*.
gi 1846471307 385 HLQRHERVHTGEKPYECSQCGKAFAC 410
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
357-382 1.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.20e-03
                          10        20
                  ....*....|....*....|....*.
gi 1846471307 357 YLRNHKRTHTGENPYKCKECGKAFAC 382
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 19-60 3.84e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.21  E-value: 3.84e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1846471307  19 SVTYDDVHVNFTGEEWVLLDASQKSLYRDVMLETYSNLTAIG 60
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
20-62 1.16e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 76.48  E-value: 1.16e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1846471307   20 VTYDDVHVNFTGEEWVLLDASQKSLYRDVMLETYSNLTAIGYK 62
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 20-57 1.14e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.35  E-value: 1.14e-16
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1846471307  20 VTYDDVHVNFTGEEWVLLDASQKSLYRDVMLETYSNLT 57
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
131-326 6.20e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 6.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471307 131 HSSLSNHEKHHTGEKPYKCIECGKAFSQQSHLQIHKRIHTG-EKPYECNQCAKAFSQQSHLQKHKRT--HTGE--KPYKC 205
Cdd:COG5048   245 PSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSC 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471307 206 --NQCNKDFSQQSHLQIHRRTHTGEKPYKC--NQCDKVFSQ-------QTHLQRHKRTHTGEKPYKCNQCGKAFAHHSYL 274
Cdd:COG5048   325 pySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPllnneppQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNL 404

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1846471307 275 EKHQRTHTGEKPYQCN--QCGKAFAHHSYLQKHKRTHTGEKPYQCNQCGKTFAC 326
Cdd:COG5048   405 SLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
145-422 1.15e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.01  E-value: 1.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471307 145 KPYKCIECGKAFSQQSHLQIHKRIHTGEKPYECNQ--CAKAFSQQSHLQKHKRTHTGEKPYKCNQCNKD-FSQQSHLQIH 221
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471307 222 RRTHTGEKPYKCNQCDKVFSQ--------QTHLQRHKRTHTGEKPYKCNQCGKAFAHHSY--------------LEKHQR 279
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSrdpqlpdlLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLpanslskdpssnlsLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471307 280 THTGEKPYQCNQCGKAFAHHSYLQKHKRTHTGEKPYQCNQCgkTFACHRSLQIHERIHTGeKPYECCQCGKTFAHHNYLR 359
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLS-SSDSSSSASESPRSSLPTA 268

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1846471307 360 NHKRTH----------TGENPYKCKECGKAFACHSHLQRHER--VHTGE--KPYEC--SQCGKAFACHSSLQNHEKNHI 422
Cdd:COG5048   269 SSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-424 1.33e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 1.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471307 157 SQQSHLQIHKRIHTGEKPYECNQCAKAFSQQSHLQKHKRTHTGEKPYKCNQCNKDFSQQSHLQIHRRT------HTGEKP 230
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsssdssSSASES 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471307 231 YKCNQCDKVFSQQTHLQRHKRTHTG-EKPYKCNQCGKAFAHHSYLEKHQRT--HTGE--KPYQC--NQCGKAFAHHSYLQ 303
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALK 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471307 304 KHKRTHTGEKPYQC--NQCGKTF-----ACHRSLQIHERIHTGEKPYECC--QCGKTFAHHNYLRNHKRTHTGENPY--K 372
Cdd:COG5048   341 RHILLHTSISPAKEklLNSSSKFspllnNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncK 420

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1846471307 373 CKECGKAFACHSHLQRHERVHTGEKPYECSQCGKAFAChsslqNHEKNHIEE 424
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD-----LDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
89-374 1.04e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471307  89 KPYEYTQCGKAFAQHSHLQGHERILTGKKPYECNQCGKAFICHSSLSNH---EKHHTGEKPYKCIECGKAFSQQSHLQIH 165
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSrhlRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471307 166 KRIHTGEKPYECNQCAKAFSQQSHLQKHKRTHTGEKPYKCNQCNKDF----------------------SQQSHLQIHRR 223
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnslhpplpanslskdpSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471307 224 THTGEKPYKCNQCDKVFSQQTHLQRHKRTHTGEKPYKCNQCGKAFAHHSYLEKHQRT------HTGEKPYQCNQCGKAFA 297
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsssdssSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471307 298 HHSYLQKHKRTHTG-EKPYQCNQCGKTFACHRSLQIHER--IHTGE--KPYECC--QCGKTFAHHNYLRNHKRTHTGENP 370
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISP 351


                  ....
gi 1846471307 371 YKCK 374
Cdd:COG5048   352 AKEK 355
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-270 1.05e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.05e-04
                          10        20
                  ....*....|....*....|....*.
gi 1846471307 245 HLQRHKRTHTGEKPYKCNQCGKAFAH 270
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
385-410 4.63e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 4.63e-04
                          10        20
                  ....*....|....*....|....*.
gi 1846471307 385 HLQRHERVHTGEKPYECSQCGKAFAC 410
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 200-310 7.10e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 7.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471307 200 EKPYKCNQCNKDFSQQSHLQIH---RRTHT-GEKPYKCN--QCDKVFSQQTHLQRHKrthtgekpyKCNQCGKAFAHHSY 273
Cdd:COG5189   315 KLPCTNSSSNGKLAHGGERNIDtpsRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPS 385

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1846471307 274 LEKHQRTHTGEKPYQCNQCGKAFAHHSYLQKHkRTHT 310
Cdd:COG5189   386 PEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
301-326 7.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 7.35e-04
                          10        20
                  ....*....|....*....|....*.
gi 1846471307 301 YLQKHKRTHTGEKPYQCNQCGKTFAC 326
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
273-298 9.21e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.21e-04
                          10        20
                  ....*....|....*....|....*.
gi 1846471307 273 YLEKHQRTHTGEKPYQCNQCGKAFAH 298
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
357-382 1.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.20e-03
                          10        20
                  ....*....|....*....|....*.
gi 1846471307 357 YLRNHKRTHTGENPYKCKECGKAFAC 382
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
189-214 1.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.46e-03
                          10        20
                  ....*....|....*....|....*.
gi 1846471307 189 HLQKHKRTHTGEKPYKCNQCNKDFSQ 214
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
217-242 2.51e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.51e-03
                          10        20
                  ....*....|....*....|....*.
gi 1846471307 217 HLQIHRRTHTGEKPYKCNQCDKVFSQ 242
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 143-226 4.22e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 4.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1846471307 143 GEKPYKC--IECGKAFSQQSHLQIHkRIHtgekpyecNQCAKAFSQQSHLQKHKRTHTGEKPYKCNQCNKDFSQQSHLQI 220
Cdd:COG5189   346 DGKPYKCpvEGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1846471307 221 HRRTHT 226
Cdd:COG5189   417 HRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
133-158 4.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.89e-03
                          10        20
                  ....*....|....*....|....*.
gi 1846471307 133 SLSNHEKHHTGEKPYKCIECGKAFSQ 158
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
161-186 5.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.90e-03
                          10        20
                  ....*....|....*....|....*.
gi 1846471307 161 HLQIHKRIHTGEKPYECNQCAKAFSQ 186
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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