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Conserved domains on  [gi|1848815791|ref|NP_001371115|]
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protein ELFN1 isoform 1 precursor [Mus musculus]

Protein Classification

LRR_8 and LRRCT domain-containing protein( domain architecture ID 12158289)

LRR_8 and LRRCT domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
85-144 1.91e-14

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 68.32  E-value: 1.91e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848815791  85 NLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEGMLRGLSKLEYLYLQANLI 144
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-190 2.67e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.74  E-value: 2.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848815791  40 WLAICSQNQPPYEAIPQQINNTIVDLRLNEnrirsvqyaSLSRFGNLTYLNLTKNEIGYIEDgAFSGQFNLQVLQLGYNR 119
Cdd:COG4886    78 SLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQ 147

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1848815791 120 LRNLTEGmLRGLSKLEYLYLQANLIEVVmASAFWECPNIVNIDLSMNRIQQLgSGTFAGLTKLSVCEIYSN 190
Cdd:COG4886   148 LTDLPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215
LRRCT smart00082
Leucine rich repeat C-terminal domain;
190-228 1.43e-06

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 1.43e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1848815791  190 NPFYCSCELLGFLRWLAAFTnATQTHDRVQCESPPVYAG 228
Cdd:smart00082   1 NPFICDCELRWLLRWLQANE-HLQDPVDLRCASPSSLRG 38
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
85-144 1.91e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 68.32  E-value: 1.91e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848815791  85 NLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEGMLRGLSKLEYLYLQANLI 144
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-190 2.67e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.74  E-value: 2.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848815791  40 WLAICSQNQPPYEAIPQQINNTIVDLRLNEnrirsvqyaSLSRFGNLTYLNLTKNEIGYIEDgAFSGQFNLQVLQLGYNR 119
Cdd:COG4886    78 SLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQ 147

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1848815791 120 LRNLTEGmLRGLSKLEYLYLQANLIEVVmASAFWECPNIVNIDLSMNRIQQLgSGTFAGLTKLSVCEIYSN 190
Cdd:COG4886   148 LTDLPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215
LRRCT smart00082
Leucine rich repeat C-terminal domain;
190-228 1.43e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 1.43e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1848815791  190 NPFYCSCELLGFLRWLAAFTnATQTHDRVQCESPPVYAG 228
Cdd:smart00082   1 NPFICDCELRWLLRWLQANE-HLQDPVDLRCASPSSLRG 38
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 65-147 1.54e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 1.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848815791  65 LRLNENRIRSVQyaSLSRFGNLTYLNLTKNEIGYIEDgaFSGQFNLQVLQLGYNRLRNLtEGmLRGLSKLEYLYLQANLI 144
Cdd:cd21340     7 LYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI-EN-LENLVNLKKLYLGGNRI 80


                  ...
gi 1848815791 145 EVV 147
Cdd:cd21340    81 SVV 83
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 162-233 1.98e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.01  E-value: 1.98e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1848815791  162 DLSMNRIQQLGSGTFAGLTKLSVCEIYSNPFYCSCELLGFLRWLAAFTNATQTHDRVQCESPPVYAGYFLLG 233
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLG 72
LRR_8 pfam13855
Leucine rich repeat;
132-182 4.58e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 4.58e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1848815791 132 SKLEYLYLQANLIEVVMASAFWECPNIVNIDLSMNRIQQLGSGTFAGLTKL 182
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSL 51
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 85-168 1.65e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.78  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848815791  85 NLTYLNLTKNEIGyiEDGA------FSGQFNLQVLQLGYNRL-----RNLTEGmLRGLSKLEYLYLQANLIEVV----MA 149
Cdd:COG5238   265 TVETLYLSGNQIG--AEGAialakaLQGNTTLTSLDLSVNRIgdegaIALAEG-LQGNKTLHTLNLAYNGIGAQgaiaLA 341

                          90
                  ....*....|....*....
gi 1848815791 150 SAFWECPNIVNIDLSMNRI 168
Cdd:COG5238   342 KALQENTTLHSLDLSDNQI 360
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 86-190 5.25e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 5.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848815791  86 LTYLNLTKNEI-GYIEDgaFSGQFNLQVLQLGYNRLRNLTEGMLRGLSKLEYLYLQANLIEVVMASAFWECPNIVNIDLS 164
Cdd:PLN00113  454 LQMLSLARNKFfGGLPD--SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLS 531

                          90       100
                  ....*....|....*....|....*.
gi 1848815791 165 MNRIQQLGSGTFAGLTKLSVCEIYSN 190
Cdd:PLN00113  532 HNQLSGQIPASFSEMPVLSQLDLSQN 557
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
85-144 1.91e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 68.32  E-value: 1.91e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848815791  85 NLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEGMLRGLSKLEYLYLQANLI 144
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-190 2.67e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.74  E-value: 2.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848815791  40 WLAICSQNQPPYEAIPQQINNTIVDLRLNEnrirsvqyaSLSRFGNLTYLNLTKNEIGYIEDgAFSGQFNLQVLQLGYNR 119
Cdd:COG4886    78 SLLLLSLLLLGLTDLGDLTNLTELDLSGNE---------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQ 147

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1848815791 120 LRNLTEGmLRGLSKLEYLYLQANLIEVVmASAFWECPNIVNIDLSMNRIQQLgSGTFAGLTKLSVCEIYSN 190
Cdd:COG4886   148 LTDLPEP-LGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGN 215
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
65-210 2.84e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.74  E-value: 2.84e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848815791  65 LRLNENRIRSVQyASLSRFGNLTYLNLTKNEIGYIEDgAFSGQFNLQVLQLGYNRLRNLTEGmLRGLSKLEYLYLQANLI 144
Cdd:COG4886   118 LDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQI 194

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1848815791 145 EvVMASAFWECPNIVNIDLSMNRIQQLgSGTFAGLTKLSVCEIYSNPfycscelLGFLRWLAAFTN 210
Cdd:COG4886   195 T-DLPEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ-------LTDLPELGNLTN 251
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-202 5.14e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 5.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848815791  44 CSQNQppYEAIPQQINN--TIVDLRLNENRIRSVQyASLSRFGNLTYLNLTKNEIGYIEDgAFSGQFNLQVLQLGYNRLR 121
Cdd:COG4886   166 LSNNQ--LTDLPEELGNltNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLT 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848815791 122 NLTEgmLRGLSKLEYLYLQANLIEVVmaSAFWECPNIVNIDLSMNRIQQLGSGTFAGLTKLSVCEIYSNPFYCSCELLGF 201
Cdd:COG4886   242 DLPE--LGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317


                  .
gi 1848815791 202 L 202
Cdd:COG4886   318 L 318
LRR_8 pfam13855
Leucine rich repeat;
109-168 8.21e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 8.21e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848815791 109 NLQVLQLGYNRLRNLTEGMLRGLSKLEYLYLQANLIEVVMASAFWECPNIVNIDLSMNRI 168
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
65-120 7.94e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 7.94e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1848815791  65 LRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRL 120
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
190-228 1.43e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 45.88  E-value: 1.43e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1848815791  190 NPFYCSCELLGFLRWLAAFTnATQTHDRVQCESPPVYAG 228
Cdd:smart00082   1 NPFICDCELRWLLRWLQANE-HLQDPVDLRCASPSSLRG 38
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 65-147 1.54e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.78  E-value: 1.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848815791  65 LRLNENRIRSVQyaSLSRFGNLTYLNLTKNEIGYIEDgaFSGQFNLQVLQLGYNRLRNLtEGmLRGLSKLEYLYLQANLI 144
Cdd:cd21340     7 LYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI-EN-LENLVNLKKLYLGGNRI 80


                  ...
gi 1848815791 145 EVV 147
Cdd:cd21340    81 SVV 83
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 162-233 1.98e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.01  E-value: 1.98e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1848815791  162 DLSMNRIQQLGSGTFAGLTKLSVCEIYSNPFYCSCELLGFLRWLAAFTNATQTHDRVQCESPPVYAGYFLLG 233
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLG 72
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 85-195 2.15e-06

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 47.54  E-value: 2.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848815791  85 NLTYLNLTKNeIGYIEDGAFSGQFNLQVLQLgYNRLRNLTEGMLRGlSKLEYLYLQANL--IEVvmaSAFWECPNIVNID 162
Cdd:pfam13306  12 SLTSITIPSS-LTSIGEYAFSNCTSLKSITL-PSSLTSIGSYAFYN-CSLTSITIPSSLtsIGE---YAFSNCSNLKSIT 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1848815791 163 LSmNRIQQLGSGTFAG--LTKLSVC----EIYSNPFY-CS 195
Cdd:pfam13306  86 LP-SNLTSIGSYAFSNcsLKSITIPssvtTIGSYAFSnCS 124
LRR_8 pfam13855
Leucine rich repeat;
132-182 4.58e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 4.58e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1848815791 132 SKLEYLYLQANLIEVVMASAFWECPNIVNIDLSMNRIQQLGSGTFAGLTKL 182
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSL 51
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 85-168 1.65e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.78  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848815791  85 NLTYLNLTKNEIGyiEDGA------FSGQFNLQVLQLGYNRL-----RNLTEGmLRGLSKLEYLYLQANLIEVV----MA 149
Cdd:COG5238   265 TVETLYLSGNQIG--AEGAialakaLQGNTTLTSLDLSVNRIgdegaIALAEG-LQGNKTLHTLNLAYNGIGAQgaiaLA 341

                          90
                  ....*....|....*....
gi 1848815791 150 SAFWECPNIVNIDLSMNRI 168
Cdd:COG5238   342 KALQENTTLHSLDLSDNQI 360
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 34-172 2.61e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.40  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848815791  34 GDKGFVWLAicsqnqppyEAIpqQINNTIVDLRLNENRIrSVQYA-----SLSRFGNLTYLNLTKNEIGyiEDGAFSGQF 108
Cdd:COG5238   249 GDEGVIALA---------EAL--KNNTTVETLYLSGNQI-GAEGAialakALQGNTTLTSLDLSVNRIG--DEGAIALAE 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848815791 109 NLQ------VLQLGYNRLRNltEGM------LRGLSKLEYLYLQANLIEVVMASAFWE----CPNIVNIDLSMNRIQQLG 172
Cdd:COG5238   315 GLQgnktlhTLNLAYNGIGA--QGAialakaLQENTTLHSLDLSDNQIGDEGAIALAKylegNTTLRELNLGKNNIGKQG 392
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 109-142 2.38e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 2.38e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1848815791 109 NLQVLQLGYNRLRNLteGMLRGLSKLEYLYLQAN 142
Cdd:pfam12799   2 NLEVLDLSNNQITDI--PPLAKLPNLETLDLSGN 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 86-190 5.25e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 5.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1848815791  86 LTYLNLTKNEI-GYIEDgaFSGQFNLQVLQLGYNRLRNLTEGMLRGLSKLEYLYLQANLIEVVMASAFWECPNIVNIDLS 164
Cdd:PLN00113  454 LQMLSLARNKFfGGLPD--SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLS 531

                          90       100
                  ....*....|....*....|....*.
gi 1848815791 165 MNRIQQLGSGTFAGLTKLSVCEIYSN 190
Cdd:PLN00113  532 HNQLSGQIPASFSEMPVLSQLDLSQN 557
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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