NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1859470953|ref|NP_001371346|]
View 

WD repeat-containing protein 5 isoform 3 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
36-327 1.26e-110

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 327.64  E-value: 1.26e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 115
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 116 ---GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 192
Cdd:COG2319   191 latGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 193 RIWDTASGQCLKTLiDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIfaNFSvTGGKWIV 272
Cdd:COG2319   271 RLWDLATGELLRTL-TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS-PDGKTLA 346

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1859470953 273 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLW 327
Cdd:COG2319   347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS--ADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
36-327 1.26e-110

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 327.64  E-value: 1.26e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 115
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 116 ---GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 192
Cdd:COG2319   191 latGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 193 RIWDTASGQCLKTLiDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIfaNFSvTGGKWIV 272
Cdd:COG2319   271 RLWDLATGELLRTL-TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS-PDGKTLA 346

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1859470953 273 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLW 327
Cdd:COG2319   347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS--ADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 37-328 3.06e-104

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 306.95  E-value: 3.06e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD- 115
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 116 --GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 193
Cdd:cd00200    81 etGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 194 IWDTASGQCLKTLIDDDNpPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNekYCIFANFSvTGGKWIVS 273
Cdd:cd00200   161 LWDLRTGKCVATLTGHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN--GVNSVAFS-PDGYLLAS 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1859470953 274 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALenDKTIKLWK 328
Cdd:cd00200   237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA--DGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 41-284 1.67e-16

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 80.52  E-value: 1.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA----YDGK---FEKTISGHKLGISDVAWSSDSNLLVSASD-DKTLK 112
Cdd:PLN00181  479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECesiiKDGRdihYPVVELASRSKLSGICWNSYIKSQVASSNfEGVVQ 558

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 113 IWD---GKCLKTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDpVSAVHFNRD-GSLIVSSS 187
Cdd:PLN00181  559 VWDvarSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAFGS 637

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 188 YDGLCRIWDTASGQC-LKTLIdDDNPPVSFVKFSPNGKYILAATlDNTLKLWDYSKGKC------LKTYTGHKNEKYciF 260
Cdd:PLN00181  638 ADHKVYYYDLRNPKLpLCTMI-GHSKTVSYVRFVDSSTLVSSST-DNTLKLWDLSMSISginetpLHSFMGHTNVKN--F 713

                         250       260
                  ....*....|....*....|....
gi 1859470953 261 ANFSVTGGkWIVSGSEDNLVYIWN 284
Cdd:PLN00181  714 VGLSVSDG-YIATGSETNEVFVYH 736
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 115-154 2.91e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 2.91e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1859470953  115 DGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 154
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
116-154 2.00e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.35  E-value: 2.00e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1859470953 116 GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 154
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
36-327 1.26e-110

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 327.64  E-value: 1.26e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 115
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 116 ---GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 192
Cdd:COG2319   191 latGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 193 RIWDTASGQCLKTLiDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIfaNFSvTGGKWIV 272
Cdd:COG2319   271 RLWDLATGELLRTL-TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS-PDGKTLA 346

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1859470953 273 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLW 327
Cdd:COG2319   347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS--ADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 37-328 3.06e-104

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 306.95  E-value: 3.06e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD- 115
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 116 --GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 193
Cdd:cd00200    81 etGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 194 IWDTASGQCLKTLIDDDNpPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNekYCIFANFSvTGGKWIVS 273
Cdd:cd00200   161 LWDLRTGKCVATLTGHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN--GVNSVAFS-PDGYLLAS 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1859470953 274 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALenDKTIKLWK 328
Cdd:cd00200   237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA--DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
36-327 2.65e-98

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 296.05  E-value: 2.65e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  36 ALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 115
Cdd:COG2319    69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 116 ---GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 192
Cdd:COG2319   149 latGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 193 RIWDTASGQCLKTLiDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIfaNFSvTGGKWIV 272
Cdd:COG2319   229 RLWDLATGKLLRTL-TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV--AFS-PDGKLLA 304

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1859470953 273 SGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLW 327
Cdd:COG2319   305 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS--DDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
12-327 2.89e-84

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 260.23  E-value: 2.89e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  12 AARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 91
Cdd:COG2319     3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  92 DVAWSSDSNLLVSASDDKTLKIWD---GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHS 168
Cdd:COG2319    83 SVAFSPDGRLLASASADGTVRLWDlatGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 169 DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNpPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKT 248
Cdd:COG2319   163 GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRT 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1859470953 249 YTGHKNEKYCIfaNFSvTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLW 327
Cdd:COG2319   242 LTGHSGSVRSV--AFS-PDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS--DDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
40-239 7.75e-74

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 233.26  E-value: 7.75e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD---G 116
Cdd:COG2319   199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDlatG 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 117 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 196
Cdd:COG2319   279 ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1859470953 197 TASGQCLKTLIDDDNpPVSFVKFSPNGKYILAATLDNTLKLWD 239
Cdd:COG2319   359 LATGELLRTLTGHTG-AVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
53-327 3.29e-67

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 216.32  E-value: 3.29e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  53 FSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD---GKCLKTLKGHSNYV 129
Cdd:COG2319     2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDaaaGALLATLLGHTAAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 130 FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 209
Cdd:COG2319    82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 210 DNPPVSfVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIfaNFSvTGGKWIVSGSEDNLVYIWNLQTKE 289
Cdd:COG2319   162 SGAVTS-VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS-PDGKLLASGSADGTVRLWDLATGK 237

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1859470953 290 IVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLW 327
Cdd:COG2319   238 LLRTLTGHSGSVRSVAFSPDGRLLASGS--ADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
37-199 3.28e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 192.82  E-value: 3.28e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD- 115
Cdd:COG2319   238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDl 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 116 --GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCR 193
Cdd:COG2319   318 atGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVR 397


                  ....*.
gi 1859470953 194 IWDTAS 199
Cdd:COG2319   398 LWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 33-196 1.94e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 177.14  E-value: 1.94e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  33 PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLK 112
Cdd:cd00200   123 ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIK 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 113 IWD---GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYD 189
Cdd:cd00200   203 LWDlstGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSAD 282


                  ....*..
gi 1859470953 190 GLCRIWD 196
Cdd:cd00200   283 GTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 41-284 1.67e-16

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 80.52  E-value: 1.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA----YDGK---FEKTISGHKLGISDVAWSSDSNLLVSASD-DKTLK 112
Cdd:PLN00181  479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECesiiKDGRdihYPVVELASRSKLSGICWNSYIKSQVASSNfEGVVQ 558

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 113 IWD---GKCLKTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDpVSAVHFNRD-GSLIVSSS 187
Cdd:PLN00181  559 VWDvarSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAFGS 637

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 188 YDGLCRIWDTASGQC-LKTLIdDDNPPVSFVKFSPNGKYILAATlDNTLKLWDYSKGKC------LKTYTGHKNEKYciF 260
Cdd:PLN00181  638 ADHKVYYYDLRNPKLpLCTMI-GHSKTVSYVRFVDSSTLVSSST-DNTLKLWDLSMSISginetpLHSFMGHTNVKN--F 713

                         250       260
                  ....*....|....*....|....
gi 1859470953 261 ANFSVTGGkWIVSGSEDNLVYIWN 284
Cdd:PLN00181  714 VGLSVSDG-YIATGSETNEVFVYH 736
PTZ00421 PTZ00421
coronin; Provisional
 85-200 1.84e-12

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 67.61  E-value: 1.84e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  85 GHKLGISDVAWSS-DSNLLVSASDDKTLKIWD----------GKCLKTLKGHSNYVFCCNFNPQS-NLIVSGSFDESVRI 152
Cdd:PTZ00421   73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGipeegltqniSDPIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVVNV 152

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1859470953 153 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG 200
Cdd:PTZ00421  153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 115-154 2.91e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 2.91e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1859470953  115 DGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 154
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 157-196 5.53e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 5.53e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1859470953  157 TGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 196
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 41-156 1.08e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 59.14  E-value: 1.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  41 LAGHTKAVSSVKFSPNGE-WLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD---G 116
Cdd:PTZ00421  121 LQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDprdG 200

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1859470953 117 KCLKTLKGH-SNYVFCCNFNPQSNLIVSGSFDES----VRIWDVK 156
Cdd:PTZ00421  201 TIVSSVEAHaSAKSQRCLWAKRKDLIITLGCSKSqqrqIMLWDTR 245
WD40 pfam00400
WD domain, G-beta repeat;
116-154 2.00e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.35  E-value: 2.00e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1859470953 116 GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWD 154
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 76-115 2.11e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 2.11e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1859470953   76 DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 115
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
158-196 2.53e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 2.53e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1859470953 158 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWD 196
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
77-115 6.02e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.19  E-value: 6.02e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1859470953  77 GKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD 115
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
37-72 1.94e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.65  E-value: 1.94e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1859470953  37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 37-72 3.12e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 3.12e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1859470953   37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIW 72
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 181-327 5.19e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.32  E-value: 5.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 181 SLIVSSSYDGLCRIWDTASGQcLKTLIDDDNPPVSFVKFSPNGKYILAA-TLDNTLKLWDYSKGKCLKTYTGHKNeKYCI 259
Cdd:PLN00181  546 SQVASSNFEGVVQVWDVARSQ-LVTEMKEHEKRVWSIDYSSADPTLLASgSDDGSVKLWSINQGVSIGTIKTKAN-ICCV 623

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1859470953 260 faNFSVTGGKWIVSGSEDNLVYIWNLQTKEI-VQKLQGHTDVVISTACHPTENIIASAaleNDKTIKLW 327
Cdd:PLN00181  624 --QFPSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTLVSSS---TDNTLKLW 687
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
73-243 6.48e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 52.77  E-value: 6.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  73 GAYDGKFEKTISGHKLGISDVAWSSDSNLL-VSASDDKTLKIWD---GKCLKTLK--GHSNYVFccnFNPQ-SNLIVSGS 145
Cdd:COG3391    53 GVALLAGLGLGAAAVADADGADAGADGRRLyVANSGSGRVSVIDlatGKVVATIPvgGGPRGLA---VDPDgGRLYVADS 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 146 FDESVRIWDVKTGKCLKTLPAHSDPVSAVhFNRDGS-LIVSSSYDGlcRIW------DTASGQCLKTLIDDDNPpvSFVK 218
Cdd:COG3391   130 GNGRVSVIDTATGKVVATIPVGAGPHGIA-VDPDGKrLYVANSGSN--TVSvivsviDTATGKVVATIPVGGGP--VGVA 204

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1859470953 219 FSPNGKYILAA--------TLDNTLKLWDYSKG 243
Cdd:COG3391   205 VSPDGRRLYVAnrgsntsnGGSNTVSVIDLATL 237
PTZ00421 PTZ00421
coronin; Provisional
 41-219 1.40e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.59  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  41 LAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTIS-------GH--KLGISDVAWSSdSNLLVSASDDKT 110
Cdd:PTZ00421   71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNISdpivhlqGHtkKVGIVSFHPSA-MNVLASAGADMV 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 111 LKIWD---GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVS--AVHFNRDGSLI-- 183
Cdd:PTZ00421  150 VNVWDverGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSqrCLWAKRKDLIItl 229

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1859470953 184 -VSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF 219
Cdd:PTZ00421  230 gCSKSQQRQIMLWDTRKMASPYSTVDLDQSSALFIPF 266
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 115-314 3.11e-06

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 48.14  E-value: 3.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 115 DGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK-----------------------TLPAHSDPV 171
Cdd:pfam20426 113 DGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEkrsrntqtefprkdhviaetpfhILCGHDDII 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 172 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAAtlDNTLKLWDYS-KGKCLKTYT 250
Cdd:pfam20426 193 TCLYVSVELDIVISGSKDGTCIFHTLREGRYVRSIRHPSGCPLSKLVASRHGRIVLYA--DDDLSLHLYSiNGKHIASSE 270

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1859470953 251 --GHKNekyCIfaNFSvTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIA 314
Cdd:pfam20426 271 snGRLN---CI--ELS-SCGEFLVCAGDQGQIVVRSMNSLEVVRRYNGIGKIITSLTVTPEECFLA 330
PTZ00420 PTZ00420
coronin; Provisional
 41-159 1.62e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.48  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  41 LAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGaydgkfektisghklgisdvawssdsnllVSASDDKTLKIWDGKCL 119
Cdd:PTZ00420   70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWE-----------------------------IPHNDESVKEIKDPQCI 120

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1859470953 120 ktLKGHSNYVFCCNFNPQSNLIV-SGSFDESVRIWDVKTGK 159
Cdd:PTZ00420  121 --LKGHKKKISIIDWNPMNYYIMcSSGFDSFVNIWDIENEK 159
PTZ00420 PTZ00420
coronin; Provisional
 122-196 3.84e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.33  E-value: 3.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 122 LKGHSNYVFCCNFNP-QSNLIVSGSFDESVRIWD----------VKTGKCLktLPAHSDPVSAVHFNRDGSLIV-SSSYD 189
Cdd:PTZ00420   70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEiphndesvkeIKDPQCI--LKGHKKKISIIDWNPMNYYIMcSSGFD 147


                  ....*..
gi 1859470953 190 GLCRIWD 196
Cdd:PTZ00420  148 SFVNIWD 154
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 93-177 4.42e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.49  E-value: 4.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  93 VAWSSDSNLLVSASDDKTL--------KIWDGkclkTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 164
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELllhrlnwqRVWTL----SPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHF 76

                          90
                  ....*....|...
gi 1859470953 165 PAHSDPVSAVHFN 177
Cdd:pfam12894  77 SAGSDLITCLGWG 89
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
214-278 4.53e-05

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 45.02  E-value: 4.53e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1859470953 214 VSFVKFSPNGKYILAATLdNTLKLWDYSKGK-CLKTYTGHKN---------EKYCIFANFSVT---GGKWIVSGSEDN 278
Cdd:COG5170   283 ISDFKFSDNGRYILSRDY-LTVKIWDVNMAKnPIKTIPMHCDlmdelndvyENDAIFDKFEISfsgDDKHVLSGSYSN 359
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 199-239 1.08e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.08e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1859470953  199 SGQCLKTLIDDDNPpVSFVKFSPNGKYILAATLDNTLKLWD 239
Cdd:smart00320   1 SGELLKTLKGHTGP-VTSVAFSPDGKYLASGSDDGTIKLWD 40
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 134-223 1.26e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 42.96  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 134 FNPQSNLIVSGSFDESVRIWDVKTGKcLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRiWDTASGQcLKTLIDDDNPP 213
Cdd:COG3386    15 WDPDGRLYWVDIPGGRIHRYDPDGGA-VEVFAEPSGRPNGLAFDPDGRLLVADHGRGLVR-FDPADGE-VTVLADEYGKP 91

                          90
                  ....*....|...
gi 1859470953 214 VSF---VKFSPNG 223
Cdd:COG3386    92 LNRpndGVVDPDG 104
WD40 pfam00400
WD domain, G-beta repeat;
243-284 1.53e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1859470953 243 GKCLKTYTGHKNEKYCIFANFSvtgGKWIVSGSEDNLVYIWN 284
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD---GKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
200-239 1.64e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.64e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1859470953 200 GQCLKTLIDDDNPpVSFVKFSPNGKYILAATLDNTLKLWD 239
Cdd:pfam00400   1 GKLLKTLEGHTGS-VTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 287-328 1.65e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 1.65e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1859470953  287 TKEIVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLWK 328
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGS--DDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 45-186 1.76e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.15  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  45 TKA-VSSVKF-SPNGEWLASSSADKliKIWgAYDGKFEK----TISGHKLGISDVAWSsDSNLLVSASDDKTLKIWDGKC 118
Cdd:PLN00181  616 TKAnICCVQFpSESGRSLAFGSADH--KVY-YYDLRNPKlplcTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSM 691

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 119 ---------LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDvktgkclKTLPA--------HSDPVSAVHFNrDGS 181
Cdd:PLN00181  692 sisginetpLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVYH-------KAFPMpvlsykfkTIDPVSGLEVD-DAS 763


                  ....*
gi 1859470953 182 LIVSS 186
Cdd:PLN00181  764 QFISS 768
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 76-241 4.10e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 40.72  E-value: 4.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953  76 DGKFEKTISGHKLG-ISDVAWSSDSN--LLVSASDDKTLKIWDGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE---S 149
Cdd:pfam08662  47 TGGPDCVVELDKEGpIHDVAWSPNGKefAVIYGYMPAKVSFFDLKGNVIHSFGEQPRNTIFWSPFGRLVLLAGFGNlagD 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 150 VRIWDVKTGKCLKTlpahsdpvsAVHFNrdgslivsssydglcriwdtasgqclktlidddnppVSFVKFSPNGKYILAA 229
Cdd:pfam08662 127 IEFWDVVNKKKIAT---------AEASN------------------------------------ATLCEWSPDGRYFLTA 161

                         170
                  ....*....|....*...
gi 1859470953 230 TL------DNTLKLWDYS 241
Cdd:pfam08662 162 TTaprlrvDNGFKIWHYN 179
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 116-200 4.25e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 41.60  E-value: 4.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 116 GKCLKTLKGHSNyvfccNFnpqsnLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 195
Cdd:pfam20426  82 AQCFATLQTPSE-----NF-----LISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVW 151


                  ....*
gi 1859470953 196 DTASG 200
Cdd:pfam20426 152 EVLRG 156
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 242-284 4.46e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 4.46e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1859470953  242 KGKCLKTYTGHKNEKYCIFANFSvtgGKWIVSGSEDNLVYIWN 284
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD---GKYLASGSDDGTIKLWD 40
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 140-238 7.93e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 39.27  E-value: 7.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 140 LIVSGSFDESVRIW--DVKTGKcLKTLPAHSDPVSAVHFNRDGSLIV-SSSYDGLCRIW--DTASGQclKTLIDDDNPPV 214
Cdd:COG0823     1 LAFTLSRDGNSDIYvvDLDGGE-PRRLTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYvvDADGGE--PRRLTFGGGYN 77

                          90       100
                  ....*....|....*....|....*
gi 1859470953 215 SFVKFSPNGKYIL-AATLDNTLKLW 238
Cdd:COG0823    78 ASPSWSPDGKRLAfVSRSDGRFDIY 102
COG3292 COG3292
Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];
126-290 1.58e-03

Periplasmic ligand-binding sensor domain [Signal transduction mechanisms];


Pssm-ID: 442521 [Multi-domain]  Cd Length: 924  Bit Score: 40.36  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 126 SNYVFCCNFNPQSNLIVS---GSFDESVRIWDVKTGKcLKTLPAHS---DPVSAVHFNRDGSLIVSSSYDGLCRiWDTAS 199
Cdd:COG3292   266 GNSVRSIAEDSDGNLWIRlwiGTYGGGLFRLDPKTGK-FKRYNPNGlpsNSVYSILEDSDGNLWIGTSGGGLYR-YDPKT 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 200 GQCLKTLIDD--DNPPVSFVKFSPNGKyILAATlDNTLKLWDYSKGKcLKTYTGHKNEK-------YCIFANFSvtGGKW 270
Cdd:COG3292   344 GKFTKFSEDNglSNNFIRSILEDSDGN-LWVGT-NGGLYRLDPKTGK-FTNFTHDPDKNglssnyiNSIFEDSD--GRLW 418

                         170       180
                  ....*....|....*....|
gi 1859470953 271 IvsGSEDNLVYIWNLQTKEI 290
Cdd:COG3292   419 I--GTDGGGLYRYDPKTGKF 436
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 101-230 1.97e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 38.11  E-value: 1.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 101 LLVSASDDKTLKIW----DGKCLKTLKGHSNYVFCCNFNPQSNLIV-----SGSFDesVRIWDVKTGKcLKTLPAHSDPV 171
Cdd:COG0823     1 LAFTLSRDGNSDIYvvdlDGGEPRRLTNSPGIDTSPAWSPDGRRIAftsdrGGGPQ--IYVVDADGGE-PRRLTFGGGYN 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1859470953 172 SAVHFNRDGSLIVSSSY-DGLCRIW--DTASGQcLKTLIDDDNPPVsfvkFSPNGKYILAAT 230
Cdd:COG0823    78 ASPSWSPDGKRLAFVSRsDGRFDIYvlDLDGGA-PRRLTDGPGSPS----WSPDGRRIVFSS 134
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 38-98 2.20e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 2.20e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1859470953  38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
Cdd:pfam12894  31 TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
COG5354 COG5354
Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];
205-291 2.52e-03

Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];


Pssm-ID: 227657 [Multi-domain]  Cd Length: 561  Bit Score: 39.47  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859470953 205 TLIDDDNPPVSFVKFSPNGKYILAATLDNtLKLWDY-SKGKCLKTYtgHKNEKYCIFAnfsvTGGKWIVSGS-------- 275
Cdd:COG5354    26 TRFESENWPVAYVSESPLGTYLFSEHAAG-VECWGGpSKAKLVRFR--HPDVKYLDFS----PNEKYLVTWSrepiiepe 98

                          90       100
                  ....*....|....*....|...
gi 1859470953 276 -------EDNLVYIWNLQTKEIV 291
Cdd:COG5354    99 ieispftSKNNVFVWDIASGMIV 121
WD40 pfam00400
WD domain, G-beta repeat;
288-327 3.61e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 3.61e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1859470953 288 KEIVQKLQGHTDVVISTACHPTENIIASAAleNDKTIKLW 327
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGS--DDGTVKVW 38
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 218-292 4.37e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 38.87  E-value: 4.37e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1859470953  218 KFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYcIFANFSvTGGKWIV-SGSEDNL---VYIWNLQTKEIVQ 292
Cdd:COG4946    395 VWSPDGKKIAFTDNRGRLWVVDLASGKVRKVDTDGYGDGI-SDLAWS-PDSKWLAySKPGPNQlsqIFLYDVETGKTVQ 471
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 179-244 5.93e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 38.48  E-value: 5.93e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1859470953  179 DGSLIVSSSYDGlcRIW--DTASGQClkTLIDDD--NPPVSFVKFSPNGKYIL-AATLDNTL---KLWDYSKGK 244
Cdd:COG4946    399 DGKKIAFTDNRG--RLWvvDLASGKV--RKVDTDgyGDGISDLAWSPDSKWLAySKPGPNQLsqiFLYDVETGK 468
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH