Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861103184  32 EVPKDVTVREGDDIEMPCAFRasgaTSYSLEIQW--WYLKEPPRELLHELAL----SVPGARSKTVRVQGNDISHR--LR 103
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYS----SSMSEASTSvyWYRQPPGKGPTFLIAYysngSEEGVKKGRFSGRGDPSNGDgsLT 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1861103184 104 LSAVRLQDEGVYECRVsDYSDDDTQEHKAQamLRVL 139
Cdd:pfam07686  77 IQNLTLSDSGTYTCAV-IPSGEGVFGKGTR--LTVL 109

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861103184  32 EVPKDVTVREGDDIEMPCAFRasgaTSYSLEIQW--WYLKEPPRELLHELAL----SVPGARSKTVRVQGNDISHR--LR 103
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYS----SSMSEASTSvyWYRQPPGKGPTFLIAYysngSEEGVKKGRFSGRGDPSNGDgsLT 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1861103184 104 LSAVRLQDEGVYECRVsDYSDDDTQEHKAQamLRVL 139
Cdd:pfam07686  77 IQNLTLSDSGTYTCAV-IPSGEGVFGKGTR--LTVL 109

Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of the collagenase stimulatory factor, basigin-1 (BSG1; also known as Cluster of Differentiation 147 (CD147) and Extracellular Matrix Metalloproteinase Inducer (EMMPRIN)) and similar proteins. CD147 is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed in nearly all cells including platelets and fibroblasts and is involved in inflammatory diseases, and cancer progression. CD147 is highly expressed in several cancers and used as a prognostic marker. The two primary isoforms of CD147 that are related to cancer progression have been identified: CD147 Ig1-Ig2 (also called Basigin-2) that is ubiquitously expressed in most tissues and CD147 Ig0-Ig1-Ig2 (also called Basigin-1) that is retinal specific and implicated in retinoblastoma. Studies showed that CD147 Ig0 domain is a potent stimulator of interleukin-6 and suggest that the CD147 Ig0 dimer is the functional unit required for activity.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861103184  28 AAFTEVPKDVTVREGDDIEMPCAFRASGATsyslEIQWWYLKEPPRELLHELalsVPGARSKTVRVQGNDISH---RLRL 104
Cdd:cd20940     1 AGFIKSPLSQQRLVGDSVELHCEAVGSPIP----EIQWWFEGQEPNEICSQL---WDGARLDRVHINATYHQHatsTISI 73

                          90       100
                  ....*....|....*....|
gi 1861103184 105 SAVRLQDEGVYECRVSDYSD 124
Cdd:cd20940    74 DNLTEEDTGTYECRASNDPD 93

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861103184  33 VPKDVTVREGDDIEMPCafRASGATSYsLEIQWWYLKEPPRELLHelalsvpgarskTVRVQGNDISHRLRLSAVRLQDE 112
Cdd:pfam00047   2 APPTVTVLEGDSATLTC--SASTGSPG-PDVTWSKEGGTLIESLK------------VKHDNGRTTQSSLLISNVTKEDA 66

                  ....*....
gi 1861103184 113 GVYECRVSD 121
Cdd:pfam00047  67 GTYTCVVNN 75

First immunoglobulin (Ig) domain of nectin-4, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of nectin-4 (also known as poliovirus receptor related protein 4 or LNIR receptor). Nectin-4 belongs to the nectin family, which is comprised of four transmembrane glycoproteins (nectins-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which participate in adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. For example nectin-4 trans-interacts with nectin-1. Nectin-4 has also been shown to interact with the actin filament-binding protein, afadin. Unlike the other nectins, which are widely expressed in adult tissues, nectin-4 is mainly expressed during embryogenesis, and is not detected in normal adult tissue or in serum. Nectin-4 is re-expressed in breast carcinoma, and patients having metastatic breast cancer have a circulating form of nectin-4 formed from the ectodomain

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861103184  35 KDVTVREGDDIEMPCAFRASGATSYsleIQWWYLKEPPRELLHELAL-------SVPGARSKTVRVQGN----DISHRLR 103
Cdd:cd05888     1 DVVTVVLGQDAKLPCFYRGDSGEQV---GQVAWARVDAGEGAQEIALlhskyglHVFPAYEGRVEQPPPprpaDGSVLLR 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1861103184 104 lSAVRlQDEGVYECRVSDYSDDDTQehkAQAMLRVL 139
Cdd:cd05888    78 -NAVQ-ADEGEYECRVSTFPAGNFQ---AELRLRVL 108

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861103184  33 VPKDVTVREGDDIEMPCAFRASGATSYSlEIQWWYLKEPPRELL---H-ELALSVPGARSKTV-----RVQGNDIShrLR 103
Cdd:cd05718     5 VPTEVTGFLGGSVTLPCSLTSPGTTKIT-QVTWMKIGAGSSQNVavfHpQYGPSVPNPYAERVeflaaRLGLRNAT--LR 81

                          90
                  ....*....|....*....
gi 1861103184 104 LSAVRLQDEGVYECRVSDY 122
Cdd:cd05718    82 IRNLRVEDEGNYICEFATF 100

Immunoglobulin V-Type;

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861103184   44 DIEMPCafRASGATSYSLEIQWwyLKEPPR---ELLHELALSVPGARSKTV--RVQGNDISHR----LRLSAVRLQDEGV 114
Cdd:smart00406   1 SVTLSC--KFSGSTFSSYYVSW--VRQPPGkglEWLGYIGSNGSSYYQESYkgRFTISKDTSKndvsLTISNLRVEDTGT 76

                   ...
gi 1861103184  115 YEC 117
Cdd:smart00406  77 YYC 79

Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint molecules; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H3 also known as CD276), a member of the B7 family of immune checkpoint molecules. B7-H3 is an important immune checkpoint member of the B7 family and shares homology with other B7 ligands such as programmed death ligand 1 (PD-L1). The B7 family molecules interact with CD28 on T-cells to provide co-stimulatory signals that regulate T-cell activation and T-helper cell differentiation. Although B7-H3 has been shown to have both co-stimulatory and co-inhibitory effects on T-cell responses, the most current studies describe B7-H3 as a T cell inhibitor that promotes tumor aggressiveness and proliferation. Moreover, B7-H3 is highly overexpressed on a wide range of human solid cancers and promotes tumor growth, metastasis, and drug resistance. Thus, B7-H3 expression in tumors often correlates with both negative prognosis and poor clinical outcome in cancer patients. B7-H3 protein contains a predicted signal peptide, V- and C-like Ig domains (IgV and IgC), a transmembrane region, and an intracellular tail.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861103184  32 EVPKD-VTVREGDDIEMPCAFRASGATSYSLEIQWWYLKEPPReLLHELALSVPGARSKTVR------------VQGNdi 98
Cdd:cd20934     1 RVPEDpVVALVGTDATLRCSFSPEPGFSLAQLSVFWQLTDTKQ-LVHSFTESQDQGRDQGSAyanrtalfpdllAQGN-- 77

                          90       100
                  ....*....|....*....|....*..
gi 1861103184  99 sHRLRLSAVRLQDEGVYEC--RVSDYS 123
Cdd:cd20934    78 -ASLRLQRVRVADEGSYTCfvSVQDFG 103