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Conserved domains on  [gi|1861100265|ref|NP_001371570|]
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V-set and transmembrane domain-containing protein 2B isoform 3 [Homo sapiens]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 12208729)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition

CATH:  2.60.40.10
PubMed:  7932691|10436082

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 1-93 7.76e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.48  E-value: 7.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861100265    1 MPCafRASGATSYSLeiqWWYlKEPPRELLHElalsvpgarskvtnkdatkiSTVRVQGNDISHRLRLSAVRLQDEGVYE 80
Cdd:smart00410  14 LSC--EASGSPPPEV---TWY-KQGGKLLAES--------------------GRFSVSRSGSTSTLTISNVTPEDSGTYT 67

                           90
                   ....*....|...
gi 1861100265   81 CRVSDYSDDDTQE 93
Cdd:smart00410  68 CAATNSSGSASSG 80
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 1-93 7.76e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.48  E-value: 7.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861100265    1 MPCafRASGATSYSLeiqWWYlKEPPRELLHElalsvpgarskvtnkdatkiSTVRVQGNDISHRLRLSAVRLQDEGVYE 80
Cdd:smart00410  14 LSC--EASGSPPPEV---TWY-KQGGKLLAES--------------------GRFSVSRSGSTSTLTISNVTPEDSGTYT 67

                           90
                   ....*....|...
gi 1861100265   81 CRVSDYSDDDTQE 93
Cdd:smart00410  68 CAATNSSGSASSG 80
Ig0_BSG1 cd20940
Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are ...
 16-88 1.09e-03

Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of the collagenase stimulatory factor, basigin-1 (BSG1; also known as Cluster of Differentiation 147 (CD147) and Extracellular Matrix Metalloproteinase Inducer (EMMPRIN)) and similar proteins. CD147 is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed in nearly all cells including platelets and fibroblasts and is involved in inflammatory diseases, and cancer progression. CD147 is highly expressed in several cancers and used as a prognostic marker. The two primary isoforms of CD147 that are related to cancer progression have been identified: CD147 Ig1-Ig2 (also called Basigin-2) that is ubiquitously expressed in most tissues and CD147 Ig0-Ig1-Ig2 (also called Basigin-1) that is retinal specific and implicated in retinoblastoma. Studies showed that CD147 Ig0 domain is a potent stimulator of interleukin-6 and suggest that the CD147 Ig0 dimer is the functional unit required for activity.


Pssm-ID: 409534  Cd Length: 116  Bit Score: 37.64  E-value: 1.09e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1861100265  16 EIQWWYLKEPPRELLHELalsVPGARSKVTNKDATKIstvrvqgNDISHRLRLSAVRLQDEGVYECRVSDYSD 88
Cdd:cd20940    31 EIQWWFEGQEPNEICSQL---WDGARLDRVHINATYH-------QHATSTISIDNLTEEDTGTYECRASNDPD 93
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 1-103 1.67e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 37.05  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861100265   1 MPCAFRasgaTSYSLEIQW--WYLKEPPRELLHELALSVPGARSKVTnKDATKISTVRVQGnDIShrLRLSAVRLQDEGV 78
Cdd:pfam07686  16 LPCTYS----SSMSEASTSvyWYRQPPGKGPTFLIAYYSNGSEEGVK-KGRFSGRGDPSNG-DGS--LTIQNLTLSDSGT 87

                          90       100
                  ....*....|....*....|....*
gi 1861100265  79 YECRVsDYSDDDTQEHKAQamLRVL 103
Cdd:pfam07686  88 YTCAV-IPSGEGVFGKGTR--LTVL 109
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 1-93 7.76e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.48  E-value: 7.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861100265    1 MPCafRASGATSYSLeiqWWYlKEPPRELLHElalsvpgarskvtnkdatkiSTVRVQGNDISHRLRLSAVRLQDEGVYE 80
Cdd:smart00410  14 LSC--EASGSPPPEV---TWY-KQGGKLLAES--------------------GRFSVSRSGSTSTLTISNVTPEDSGTYT 67

                           90
                   ....*....|...
gi 1861100265   81 CRVSDYSDDDTQE 93
Cdd:smart00410  68 CAATNSSGSASSG 80
Ig0_BSG1 cd20940
Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are ...
 16-88 1.09e-03

Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of the collagenase stimulatory factor, basigin-1 (BSG1; also known as Cluster of Differentiation 147 (CD147) and Extracellular Matrix Metalloproteinase Inducer (EMMPRIN)) and similar proteins. CD147 is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed in nearly all cells including platelets and fibroblasts and is involved in inflammatory diseases, and cancer progression. CD147 is highly expressed in several cancers and used as a prognostic marker. The two primary isoforms of CD147 that are related to cancer progression have been identified: CD147 Ig1-Ig2 (also called Basigin-2) that is ubiquitously expressed in most tissues and CD147 Ig0-Ig1-Ig2 (also called Basigin-1) that is retinal specific and implicated in retinoblastoma. Studies showed that CD147 Ig0 domain is a potent stimulator of interleukin-6 and suggest that the CD147 Ig0 dimer is the functional unit required for activity.


Pssm-ID: 409534  Cd Length: 116  Bit Score: 37.64  E-value: 1.09e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1861100265  16 EIQWWYLKEPPRELLHELalsVPGARSKVTNKDATKIstvrvqgNDISHRLRLSAVRLQDEGVYECRVSDYSD 88
Cdd:cd20940    31 EIQWWFEGQEPNEICSQL---WDGARLDRVHINATYH-------QHATSTISIDNLTEEDTGTYECRASNDPD 93
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 1-103 1.67e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 37.05  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861100265   1 MPCAFRasgaTSYSLEIQW--WYLKEPPRELLHELALSVPGARSKVTnKDATKISTVRVQGnDIShrLRLSAVRLQDEGV 78
Cdd:pfam07686  16 LPCTYS----SSMSEASTSvyWYRQPPGKGPTFLIAYYSNGSEEGVK-KGRFSGRGDPSNG-DGS--LTIQNLTLSDSGT 87

                          90       100
                  ....*....|....*....|....*
gi 1861100265  79 YECRVsDYSDDDTQEHKAQamLRVL 103
Cdd:pfam07686  88 YTCAV-IPSGEGVFGKGTR--LTVL 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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