|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-95 |
1.15e-53 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
:
Pssm-ID: 436519 Cd Length: 95 Bit Score: 182.15 E-value: 1.15e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 1 MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQL 80
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPTQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 1864245117 81 EVPLDLEVLLLSTFG 95
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
222-383 |
2.49e-46 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
:
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 164.02 E-value: 2.49e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 222 RVTVLLGKAGMGKTTLAHRLCQKWAEGHLN-CFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNAD 300
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPqGFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 301 QVLLIFDGLDEALQPMGP-DGPGPVLTLFSHLCNGTLLPGCRVMATSRPG---KLPACLpAEAAMVHMLGFDGPRVEEYV 376
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQlDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGL-EEPRYLEVRGFSESDRKQYV 159
|
....*..
gi 1864245117 377 NHFFSAQ 383
Cdd:pfam05729 160 RKYFSDE 166
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
173-530 |
5.07e-24 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
:
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 109.89 E-value: 5.07e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 173 HQVYVPPILRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRV-NKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLN 251
Cdd:COG5635 131 LSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERIESLKRLELlEAKKKRLLILGEPGSGKTTLLRYLALELAERYLD 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 252 CFQAL-FLFEFRQLNLITRFLtpsELLFDLYLSPESDHDTVFQYLeKNADQVLLIFDGLDEALQPMGPDGpgpVLTLFSH 330
Cdd:COG5635 211 AEDPIpILIELRDLAEEASLE---DLLAEALEKRGGEPEDALERL-LRNGRLLLLLDGLDEVPDEADRDE---VLNQLRR 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 331 LCNGtlLPGCRVMATSRPGKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGALVE-LQTNGRLRSLCAVPALC 409
Cdd:COG5635 284 FLER--YPKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKKWFEATERKAERLLEaLEENPELRELARNPLLL 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 410 QVacLCLHHLLPDHAPGQSVALLpnmtQLYMQMVL-------ALSPPGHLPTSSLLD-LGEVALRGLETGKVIFYAKD-- 479
Cdd:COG5635 362 TL--LALLLRERGELPDTRAELY----EQFVELLLerwdeqrGLTIYRELSREELRElLSELALAMQENGRTEFAREEle 435
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1864245117 480 --IAPPLIAFGATHSLLTSFCVCTGP--GHQQTGYAFTHLSLQEFLAALHLMASP 530
Cdd:COG5635 436 eiLREYLGRRKDAEALLDELLLRTGLlvERGEGRYSFAHRSFQEYLAARALVEEL 490
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
751-1069 |
1.01e-16 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 84.46 E-value: 1.01e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 751 DNQLSDQVVLNIVEVLPHLPRLRkLDLSSNSICVSTLLCLARVAVTCPTVRMLQArEADLIFLLSPPTETTAELQRAPDL 830
Cdd:COG5238 69 GDPGLNPVALEKAAEAFPTQLLV-VDWEGAEEVSPVALAETATAVATPPPDLRRI-MAKTLEDSLILYLALPRRINLIQV 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 831 QesdgqRKGAQSRSLTLRLQKCQLQvHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGL 910
Cdd:COG5238 147 L-----KDPLGGNAVHLLGLAARLG-LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPI 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 911 SVAGVHCVLRAVSACWTLAELHISlqhktvifmfaqepEEQKGPQERAAFLDSLmlqmpsELPLSSRRMRLTHCGLQEKH 990
Cdd:COG5238 221 GDEGAEILAEALKGNKSLTTLDLS--------------NNQIGDEGVIALAEAL------KNNTTVETLYLSGNQIGAEG 280
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245117 991 LEQLCKALGGSCHLGHLHLdfSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISF 1069
Cdd:COG5238 281 AIALAKALQGNTTLTSLDL--SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSD 357
|
|
| NLRC4_HD2 super family |
cl39284 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
514-628 |
5.58e-09 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
The actual alignment was detected with superfamily member pfam17776:
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 55.38 E-value: 5.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 514 HLSLQEFLAALHLMASPKVNK-DTLTQYVTLHSRW------VQRTKARLGLSDHLPTFLAGLASCTCRPFLSHLaQGNED 586
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKsNPLKEFFGLRKREslksllDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGL-LGCKL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1864245117 587 CVGAKQaAVVQVLKKLATRKLTGPKVVELCHCVDETQEPELA 628
Cdd:pfam17776 80 SSEIKQ-ELLQWIKSLIQKELSSERFLNLFHCLYELQDESFV 120
|
|
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1009-1358 |
4.87e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 46.96 E-value: 4.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 1009 LDFSGNALGDEGAArlaQLLPGLGALQSLNLSENGLSLDAVLGLVRcfstlqwlfRLDISFESQHILLRGDKTSRDMWAT 1088
Cdd:cd00116 3 LSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALAS---------ALRPQPSLKELCLSLNETGRIPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 1089 GSLPD-------------------FPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLE-LQLSCEFLS 1148
Cdd:cd00116 71 QSLLQgltkgcglqeldlsdnalgPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEkLVLGRNRLE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 1149 DQSLETLldclpqlpqlsllqlsqtglspkspfllANTLSLCPRVKKVDLR--SLHHATLH-----FRSNEEEEGVccGL 1221
Cdd:cd00116 151 GASCEAL----------------------------AKALRANRDLKELNLAnnGIGDAGIRalaegLKANCNLEVL--DL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 1222 SANLLGDSGLRCLLECLPQVPISGLLDLSHNSISQESALYLLETLPScprvreasvnlgseqsfrihfsrEDQAGKTLRL 1301
Cdd:cd00116 201 NNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLS-----------------------PNISLLTLSL 257
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1864245117 1302 SECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQ--KQLA--ILLSLVGRPAGLFSLRDS 1358
Cdd:cd00116 258 SCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEegAQLLaeSLLEPGNELESLWVKDDS 318
|
|
| LRR super family |
cl34836 |
Leucine-rich repeat (LRR) protein [Transcription]; |
649-782 |
5.87e-05 |
|
Leucine-rich repeat (LRR) protein [Transcription];
The actual alignment was detected with superfamily member COG4886:
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 47.24 E-value: 5.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 649 TDLATLTNiLEHreapihLDFDGCPLEpHCPEALVGCGQIENLSFKSRKCGDafaeaLSRSLPTMGRLQMLGLAGSKITA 728
Cdd:COG4886 153 EPLGNLTN-LKS------LDLSNNQLT-DLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD 219
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1864245117 729 rgishLVKALPLCPQLKEVSFRDNQLSDqvvlniVEVLPHLPRLRKLDLSSNSI 782
Cdd:COG4886 220 -----LPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQL 262
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-95 |
1.15e-53 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
Pssm-ID: 436519 Cd Length: 95 Bit Score: 182.15 E-value: 1.15e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 1 MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQL 80
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPTQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 1864245117 81 EVPLDLEVLLLSTFG 95
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
222-383 |
2.49e-46 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 164.02 E-value: 2.49e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 222 RVTVLLGKAGMGKTTLAHRLCQKWAEGHLN-CFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNAD 300
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPqGFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 301 QVLLIFDGLDEALQPMGP-DGPGPVLTLFSHLCNGTLLPGCRVMATSRPG---KLPACLpAEAAMVHMLGFDGPRVEEYV 376
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQlDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGL-EEPRYLEVRGFSESDRKQYV 159
|
....*..
gi 1864245117 377 NHFFSAQ 383
Cdd:pfam05729 160 RKYFSDE 166
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
173-530 |
5.07e-24 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 109.89 E-value: 5.07e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 173 HQVYVPPILRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRV-NKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLN 251
Cdd:COG5635 131 LSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERIESLKRLELlEAKKKRLLILGEPGSGKTTLLRYLALELAERYLD 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 252 CFQAL-FLFEFRQLNLITRFLtpsELLFDLYLSPESDHDTVFQYLeKNADQVLLIFDGLDEALQPMGPDGpgpVLTLFSH 330
Cdd:COG5635 211 AEDPIpILIELRDLAEEASLE---DLLAEALEKRGGEPEDALERL-LRNGRLLLLLDGLDEVPDEADRDE---VLNQLRR 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 331 LCNGtlLPGCRVMATSRPGKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGALVE-LQTNGRLRSLCAVPALC 409
Cdd:COG5635 284 FLER--YPKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKKWFEATERKAERLLEaLEENPELRELARNPLLL 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 410 QVacLCLHHLLPDHAPGQSVALLpnmtQLYMQMVL-------ALSPPGHLPTSSLLD-LGEVALRGLETGKVIFYAKD-- 479
Cdd:COG5635 362 TL--LALLLRERGELPDTRAELY----EQFVELLLerwdeqrGLTIYRELSREELRElLSELALAMQENGRTEFAREEle 435
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1864245117 480 --IAPPLIAFGATHSLLTSFCVCTGP--GHQQTGYAFTHLSLQEFLAALHLMASP 530
Cdd:COG5635 436 eiLREYLGRRKDAEALLDELLLRTGLlvERGEGRYSFAHRSFQEYLAARALVEEL 490
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
751-1069 |
1.01e-16 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 84.46 E-value: 1.01e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 751 DNQLSDQVVLNIVEVLPHLPRLRkLDLSSNSICVSTLLCLARVAVTCPTVRMLQArEADLIFLLSPPTETTAELQRAPDL 830
Cdd:COG5238 69 GDPGLNPVALEKAAEAFPTQLLV-VDWEGAEEVSPVALAETATAVATPPPDLRRI-MAKTLEDSLILYLALPRRINLIQV 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 831 QesdgqRKGAQSRSLTLRLQKCQLQvHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGL 910
Cdd:COG5238 147 L-----KDPLGGNAVHLLGLAARLG-LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPI 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 911 SVAGVHCVLRAVSACWTLAELHISlqhktvifmfaqepEEQKGPQERAAFLDSLmlqmpsELPLSSRRMRLTHCGLQEKH 990
Cdd:COG5238 221 GDEGAEILAEALKGNKSLTTLDLS--------------NNQIGDEGVIALAEAL------KNNTTVETLYLSGNQIGAEG 280
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245117 991 LEQLCKALGGSCHLGHLHLdfSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISF 1069
Cdd:COG5238 281 AIALAKALQGNTTLTSLDL--SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSD 357
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
690-1069 |
1.25e-12 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 70.46 E-value: 1.25e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 690 NLSFKSRKCGDAFAEALSRSLPTMgrlQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQL--SDQVVLNIVEVLP 767
Cdd:cd00116 2 QLSLKGELLKTERATELLPKLLCL---QVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 768 HLPRLRKLDLSSNSICvstllclarvAVTCPTVrmlqareadlifllspptettAELQRAPDLQEsdgqrkgaqsrsltL 847
Cdd:cd00116 79 KGCGLQELDLSDNALG----------PDGCGVL---------------------ESLLRSSSLQE--------------L 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 848 RLQKCQLQVhDAEALIA--LLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGLSVAGVHCVLRAvsac 925
Cdd:cd00116 114 KLNNNGLGD-RGLRLLAkgLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEG---- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 926 wtlaelhislqhktvifmfaqepeeqkgpqeraafldslmLQMPSELplssRRMRLTHCGLQEKHLEQLCKALGGSCHLg 1005
Cdd:cd00116 189 ----------------------------------------LKANCNL----EVLDLNNNGLTDEGASALAETLASLKSL- 223
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1864245117 1006 hLHLDFSGNALGDEGAARLA-QLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISF 1069
Cdd:cd00116 224 -EVLNLGDNNLTDAGAAALAsALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRG 287
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
514-628 |
5.58e-09 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 55.38 E-value: 5.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 514 HLSLQEFLAALHLMASPKVNK-DTLTQYVTLHSRW------VQRTKARLGLSDHLPTFLAGLASCTCRPFLSHLaQGNED 586
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKsNPLKEFFGLRKREslksllDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGL-LGCKL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1864245117 587 CVGAKQaAVVQVLKKLATRKLTGPKVVELCHCVDETQEPELA 628
Cdd:pfam17776 80 SSEIKQ-ELLQWIKSLIQKELSSERFLNLFHCLYELQDESFV 120
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1009-1358 |
4.87e-05 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 46.96 E-value: 4.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 1009 LDFSGNALGDEGAArlaQLLPGLGALQSLNLSENGLSLDAVLGLVRcfstlqwlfRLDISFESQHILLRGDKTSRDMWAT 1088
Cdd:cd00116 3 LSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALAS---------ALRPQPSLKELCLSLNETGRIPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 1089 GSLPD-------------------FPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLE-LQLSCEFLS 1148
Cdd:cd00116 71 QSLLQgltkgcglqeldlsdnalgPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEkLVLGRNRLE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 1149 DQSLETLldclpqlpqlsllqlsqtglspkspfllANTLSLCPRVKKVDLR--SLHHATLH-----FRSNEEEEGVccGL 1221
Cdd:cd00116 151 GASCEAL----------------------------AKALRANRDLKELNLAnnGIGDAGIRalaegLKANCNLEVL--DL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 1222 SANLLGDSGLRCLLECLPQVPISGLLDLSHNSISQESALYLLETLPScprvreasvnlgseqsfrihfsrEDQAGKTLRL 1301
Cdd:cd00116 201 NNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLS-----------------------PNISLLTLSL 257
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1864245117 1302 SECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQ--KQLA--ILLSLVGRPAGLFSLRDS 1358
Cdd:cd00116 258 SCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEegAQLLaeSLLEPGNELESLWVKDDS 318
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
649-782 |
5.87e-05 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 47.24 E-value: 5.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 649 TDLATLTNiLEHreapihLDFDGCPLEpHCPEALVGCGQIENLSFKSRKCGDafaeaLSRSLPTMGRLQMLGLAGSKITA 728
Cdd:COG4886 153 EPLGNLTN-LKS------LDLSNNQLT-DLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD 219
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1864245117 729 rgishLVKALPLCPQLKEVSFRDNQLSDqvvlniVEVLPHLPRLRKLDLSSNSI 782
Cdd:COG4886 220 -----LPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQL 262
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
705-783 |
3.66e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.54 E-value: 3.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 705 ALSRSLptmgrlQMLGLAGSKITA-RGISHLVkalplcpQLKEVSFRDNQLSDqvVLNIVEVLPHLPRLRKLDLSSNSIC 783
Cdd:cd21340 117 ALSNSL------RVLNISGNNIDSlEPLAPLR-------NLEQLDASNNQISD--LEELLDLLSSWPSLRELDLTGNPVC 181
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
221-365 |
9.37e-03 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 38.12 E-value: 9.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 221 PRVTVLLGKAGMGKTTLAHRLCqkwaeGHLNCFQALFLF---EFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEK 297
Cdd:smart00382 2 GEVILIVGPPGSGKTTLARALA-----RELGPPGGGVIYidgEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARK 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 298 NADQVLLIfdglDEA--LQPMGPDGPGPVLTLFSHLCNGTLLPGCRVMATSRPGKlpacLPAEAAMVHML 365
Cdd:smart00382 77 LKPDVLIL----DEItsLLDAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEK----DLGPALLRRRF 138
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-95 |
1.15e-53 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
Pssm-ID: 436519 Cd Length: 95 Bit Score: 182.15 E-value: 1.15e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 1 MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNKLHVQGSDTWQSFIHCVCMQL 80
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPTQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 1864245117 81 EVPLDLEVLLLSTFG 95
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
222-383 |
2.49e-46 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 164.02 E-value: 2.49e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 222 RVTVLLGKAGMGKTTLAHRLCQKWAEGHLN-CFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNAD 300
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPqGFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 301 QVLLIFDGLDEALQPMGP-DGPGPVLTLFSHLCNGTLLPGCRVMATSRPG---KLPACLpAEAAMVHMLGFDGPRVEEYV 376
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQlDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGL-EEPRYLEVRGFSESDRKQYV 159
|
....*..
gi 1864245117 377 NHFFSAQ 383
Cdd:pfam05729 160 RKYFSDE 166
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
173-530 |
5.07e-24 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 109.89 E-value: 5.07e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 173 HQVYVPPILRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRV-NKGPRVTVLLGKAGMGKTTLAHRLCQKWAEGHLN 251
Cdd:COG5635 131 LSESDLLLALLILLLDADGLLVSLDDLYVPLNLLERIESLKRLELlEAKKKRLLILGEPGSGKTTLLRYLALELAERYLD 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 252 CFQAL-FLFEFRQLNLITRFLtpsELLFDLYLSPESDHDTVFQYLeKNADQVLLIFDGLDEALQPMGPDGpgpVLTLFSH 330
Cdd:COG5635 211 AEDPIpILIELRDLAEEASLE---DLLAEALEKRGGEPEDALERL-LRNGRLLLLLDGLDEVPDEADRDE---VLNQLRR 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 331 LCNGtlLPGCRVMATSRPGKLPACLPAEAAMVHMLGFDGPRVEEYVNHFFSAQPSREGALVE-LQTNGRLRSLCAVPALC 409
Cdd:COG5635 284 FLER--YPKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKKWFEATERKAERLLEaLEENPELRELARNPLLL 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 410 QVacLCLHHLLPDHAPGQSVALLpnmtQLYMQMVL-------ALSPPGHLPTSSLLD-LGEVALRGLETGKVIFYAKD-- 479
Cdd:COG5635 362 TL--LALLLRERGELPDTRAELY----EQFVELLLerwdeqrGLTIYRELSREELRElLSELALAMQENGRTEFAREEle 435
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1864245117 480 --IAPPLIAFGATHSLLTSFCVCTGP--GHQQTGYAFTHLSLQEFLAALHLMASP 530
Cdd:COG5635 436 eiLREYLGRRKDAEALLDELLLRTGLlvERGEGRYSFAHRSFQEYLAARALVEEL 490
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
751-1069 |
1.01e-16 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 84.46 E-value: 1.01e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 751 DNQLSDQVVLNIVEVLPHLPRLRkLDLSSNSICVSTLLCLARVAVTCPTVRMLQArEADLIFLLSPPTETTAELQRAPDL 830
Cdd:COG5238 69 GDPGLNPVALEKAAEAFPTQLLV-VDWEGAEEVSPVALAETATAVATPPPDLRRI-MAKTLEDSLILYLALPRRINLIQV 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 831 QesdgqRKGAQSRSLTLRLQKCQLQvHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGL 910
Cdd:COG5238 147 L-----KDPLGGNAVHLLGLAARLG-LLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPI 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 911 SVAGVHCVLRAVSACWTLAELHISlqhktvifmfaqepEEQKGPQERAAFLDSLmlqmpsELPLSSRRMRLTHCGLQEKH 990
Cdd:COG5238 221 GDEGAEILAEALKGNKSLTTLDLS--------------NNQIGDEGVIALAEAL------KNNTTVETLYLSGNQIGAEG 280
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245117 991 LEQLCKALGGSCHLGHLHLdfSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISF 1069
Cdd:COG5238 281 AIALAKALQGNTTLTSLDL--SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSD 357
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
687-915 |
7.54e-15 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 78.68 E-value: 7.54e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 687 QIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVL 766
Cdd:COG5238 181 SVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 767 PHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQAREADLIFllspptETTAELqrAPDLQESDGQRkgaqsrslT 846
Cdd:COG5238 261 KNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGD------EGAIAL--AEGLQGNKTLH--------T 324
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1864245117 847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGLSVAGV 915
Cdd:COG5238 325 LNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGA 393
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
715-1052 |
2.11e-14 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 77.14 E-value: 2.11e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 715 RLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVa 794
Cdd:COG5238 181 SVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEA- 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 795 vtcptvrmLQareadlifllsppTETTAElqrapdlqesdgqrkgaqsrslTLRLQKCQLQVHDAEALIALLQEGPHLEE 874
Cdd:COG5238 260 --------LK-------------NNTTVE----------------------TLYLSGNQIGAEGAIALAKALQGNTTLTS 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 875 VDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGLSVAGVHCVLRAVsacWTLAELHIslqhktvifmfaqepeeqkgp 954
Cdd:COG5238 297 LDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKAL---QENTTLHS--------------------- 352
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 955 qeraafldslmlqmpselplssrrmrlthcglqekhleqlckalggschlghlhLDFSGNALGDEGAARLAQLLPGLGAL 1034
Cdd:COG5238 353 ------------------------------------------------------LDLSDNQIGDEGAIALAKYLEGNTTL 378
|
330
....*....|....*...
gi 1864245117 1035 QSLNLSENGLSLDAVLGL 1052
Cdd:COG5238 379 RELNLGKNNIGKQGAEAL 396
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
690-1069 |
1.25e-12 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 70.46 E-value: 1.25e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 690 NLSFKSRKCGDAFAEALSRSLPTMgrlQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQL--SDQVVLNIVEVLP 767
Cdd:cd00116 2 QLSLKGELLKTERATELLPKLLCL---QVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgrIPRGLQSLLQGLT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 768 HLPRLRKLDLSSNSICvstllclarvAVTCPTVrmlqareadlifllspptettAELQRAPDLQEsdgqrkgaqsrsltL 847
Cdd:cd00116 79 KGCGLQELDLSDNALG----------PDGCGVL---------------------ESLLRSSSLQE--------------L 113
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 848 RLQKCQLQVhDAEALIA--LLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNNGLSVAGVHCVLRAvsac 925
Cdd:cd00116 114 KLNNNGLGD-RGLRLLAkgLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEG---- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 926 wtlaelhislqhktvifmfaqepeeqkgpqeraafldslmLQMPSELplssRRMRLTHCGLQEKHLEQLCKALGGSCHLg 1005
Cdd:cd00116 189 ----------------------------------------LKANCNL----EVLDLNNNGLTDEGASALAETLASLKSL- 223
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1864245117 1006 hLHLDFSGNALGDEGAARLA-QLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISF 1069
Cdd:cd00116 224 -EVLNLGDNNLTDAGAAALAsALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRG 287
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
680-910 |
5.75e-12 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 69.43 E-value: 5.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 680 EALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVV 759
Cdd:COG5238 230 EALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGA 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 760 LNIVEVLPHLPRLRKLDLSSNSIcvstllclarvavtcptvrmlqaREADLIFLLspptettAELQRAPDLQesdgqrkg 839
Cdd:COG5238 310 IALAEGLQGNKTLHTLNLAYNGI-----------------------GAQGAIALA-------KALQENTTLH-------- 351
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1864245117 840 aqsrslTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAeAASQLHIARKLDLSNNGL 910
Cdd:COG5238 352 ------SLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALI-DALQTNRLHTLILDGNLI 415
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
661-893 |
1.72e-11 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 67.00 E-value: 1.72e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 661 REAPIHLDFDGCPLePHCPEAL--VGCGQienlsfksRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKAL 738
Cdd:cd00116 119 GLGDRGLRLLAKGL-KDLPPALekLVLGR--------NRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGL 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 739 PLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSIcvsTLLCLARVAvtcptvrmlqareadlifllsppt 818
Cdd:cd00116 190 KANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNL---TDAGAAALA------------------------ 242
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1864245117 819 ettaelqrapdlqesDGQRKGAQSRsLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEA 893
Cdd:cd00116 243 ---------------SALLSPNISL-LTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAES 301
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
514-628 |
5.58e-09 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 55.38 E-value: 5.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 514 HLSLQEFLAALHLMASPKVNK-DTLTQYVTLHSRW------VQRTKARLGLSDHLPTFLAGLASCTCRPFLSHLaQGNED 586
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKsNPLKEFFGLRKREslksllDKALKSKNGHLDLFLRFLFGLLNEENQRLLEGL-LGCKL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1864245117 587 CVGAKQaAVVQVLKKLATRKLTGPKVVELCHCVDETQEPELA 628
Cdd:pfam17776 80 SSEIKQ-ELLQWIKSLIQKELSSERFLNLFHCLYELQDESFV 120
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
666-914 |
1.25e-07 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 55.05 E-value: 1.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 666 HLDFDGCPLEPHCPEALVGCGQI---ENLSFKSRKCGDAFAEALSRSLPTMG-RLQMLGLAGSKITARGISHLVKALPLC 741
Cdd:cd00116 85 ELDLSDNALGPDGCGVLESLLRSsslQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRAN 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 742 PQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSIcvstllclarvavTCPTVRMLQAREADLIFLLspptett 821
Cdd:cd00116 165 RDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGL-------------TDEGASALAETLASLKSLE------- 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 822 aelqrapdlqesdgqrkgaqsrslTLRLQKCQLQVHDAEALI-ALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIA 900
Cdd:cd00116 225 ------------------------VLNLGDNNLTDAGAAALAsALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESL 280
|
250
....*....|....
gi 1864245117 901 RKLDLSNNGLSVAG 914
Cdd:cd00116 281 LELDLRGNKFGEEG 294
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
704-911 |
1.27e-06 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 52.63 E-value: 1.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 704 EALSRSLPTMGRLQMLGLAGSKITargisHLVKALPLCPQLKEVSFRDNQLSDqvvlnIVEVLPHLPRLRKLDLSSNSIc 783
Cdd:COG4886 126 TDLPEELANLTNLKELDLSNNQLT-----DLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQI- 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 784 vSTL-LCLARvavtCPTVRMLQAREADLifllsppTETTAELQRAPDLQesdgqrkgaqsrslTLRLQKCQLQVhdaeal 862
Cdd:COG4886 195 -TDLpEPLGN----LTNLEELDLSGNQL-------TDLPEPLANLTNLE--------------TLDLSNNQLTD------ 242
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1864245117 863 IALLQEGPHLEEVDLSGNQLEDegcrlmAEAASQLHIARKLDLSNNGLS 911
Cdd:COG4886 243 LPELGNLTNLEELDLSNNQLTD------LPPLANLTNLKTLDLSNNQLT 285
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
845-1284 |
1.85e-06 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.59 E-value: 1.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 845 LTLRLQKCQLQVHDAEALIALLQegpHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSNN--GLSVAGVHCVLRAV 922
Cdd:cd00116 1 LQLSLKGELLKTERATELLPKLL---CLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNetGRIPRGLQSLLQGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 923 SACWTLAELHISlqhktvifmfaqepeeqkgpqeRAAFLDSLMLQMPSELPLSS-RRMRLTHCGLQEKHLEQLCKALGG- 1000
Cdd:cd00116 78 TKGCGLQELDLS----------------------DNALGPDGCGVLESLLRSSSlQELKLNNNGLGDRGLRLLAKGLKDl 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 1001 SCHLGHLHLdfSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDisfesqhillrgdk 1080
Cdd:cd00116 136 PPALEKLVL--GRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLD-------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 1081 tsrdmwatgslpdfpaaakflgfrqrciprslcLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLp 1160
Cdd:cd00116 200 ---------------------------------LNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASAL- 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 1161 qlpqlsllqlsqtglspkspfllantLSLCPRVKKVDLrslhhatlhfrsneeeegvccglSANLLGDSGLRCLLECLPQ 1240
Cdd:cd00116 246 --------------------------LSPNISLLTLSL-----------------------SCNDITDDGAKDLAEVLAE 276
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1864245117 1241 VPISGLLDLSHNSISQESALYLLETLpSCPRVREASVNLGSEQS 1284
Cdd:cd00116 277 KESLLELDLRGNKFGEEGAQLLAESL-LEPGNELESLWVKDDSF 319
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
716-911 |
9.21e-06 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 49.93 E-value: 9.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 716 LQMLGLAGSKITargisHLVKALPLCPQLKEVSFRDNQLSDqvvlnIVEVLPHLPRLRKLDLSSNSICVstllcLARVAV 795
Cdd:COG4886 115 LESLDLSGNQLT-----DLPEELANLTNLKELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLTD-----LPEELG 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 796 TCPTVRMLQAREADLifllsppTETTAELQRAPDLQEsdgqrkgaqsrsltLRLQKCQLQvhDAEALIALLqegPHLEEV 875
Cdd:COG4886 180 NLTNLKELDLSNNQI-------TDLPEPLGNLTNLEE--------------LDLSGNQLT--DLPEPLANL---TNLETL 233
|
170 180 190
....*....|....*....|....*....|....*.
gi 1864245117 876 DLSGNQLEDegcrlmAEAASQLHIARKLDLSNNGLS 911
Cdd:COG4886 234 DLSNNQLTD------LPELGNLTNLEELDLSNNQLT 263
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1009-1358 |
4.87e-05 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 46.96 E-value: 4.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 1009 LDFSGNALGDEGAArlaQLLPGLGALQSLNLSENGLSLDAVLGLVRcfstlqwlfRLDISFESQHILLRGDKTSRDMWAT 1088
Cdd:cd00116 3 LSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALAS---------ALRPQPSLKELCLSLNETGRIPRGL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 1089 GSLPD-------------------FPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLE-LQLSCEFLS 1148
Cdd:cd00116 71 QSLLQgltkgcglqeldlsdnalgPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEkLVLGRNRLE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 1149 DQSLETLldclpqlpqlsllqlsqtglspkspfllANTLSLCPRVKKVDLR--SLHHATLH-----FRSNEEEEGVccGL 1221
Cdd:cd00116 151 GASCEAL----------------------------AKALRANRDLKELNLAnnGIGDAGIRalaegLKANCNLEVL--DL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 1222 SANLLGDSGLRCLLECLPQVPISGLLDLSHNSISQESALYLLETLPScprvreasvnlgseqsfrihfsrEDQAGKTLRL 1301
Cdd:cd00116 201 NNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLS-----------------------PNISLLTLSL 257
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1864245117 1302 SECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQ--KQLA--ILLSLVGRPAGLFSLRDS 1358
Cdd:cd00116 258 SCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEegAQLLaeSLLEPGNELESLWVKDDS 318
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
649-782 |
5.87e-05 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 47.24 E-value: 5.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 649 TDLATLTNiLEHreapihLDFDGCPLEpHCPEALVGCGQIENLSFKSRKCGDafaeaLSRSLPTMGRLQMLGLAGSKITA 728
Cdd:COG4886 153 EPLGNLTN-LKS------LDLSNNQLT-DLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLTD 219
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1864245117 729 rgishLVKALPLCPQLKEVSFRDNQLSDqvvlniVEVLPHLPRLRKLDLSSNSI 782
Cdd:COG4886 220 -----LPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQL 262
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
650-782 |
5.17e-04 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 44.15 E-value: 5.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 650 DLATLTNIlehreapIHLDFDGCPLEpHCPEALVGCGQIENLSFKSRKCGDafaeaLSRSLPTMGRLQMLGLAGSKITAr 729
Cdd:COG4886 131 ELANLTNL-------KELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLSNNQITD- 196
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1864245117 730 gishLVKALPLCPQLKEVSFRDNQLSDqvvlnIVEVLPHLPRLRKLDLSSNSI 782
Cdd:COG4886 197 ----LPEPLGNLTNLEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQL 240
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
680-772 |
1.57e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 42.85 E-value: 1.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 680 EALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALpLCPQLKEVSFRDNQLSDQVV 759
Cdd:COG5238 342 KALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQ 420
|
90
....*....|...
gi 1864245117 760 LNIVEVLPHLPRL 772
Cdd:COG5238 421 QRLEQLLERIKSV 433
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
705-783 |
3.66e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.54 E-value: 3.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 705 ALSRSLptmgrlQMLGLAGSKITA-RGISHLVkalplcpQLKEVSFRDNQLSDqvVLNIVEVLPHLPRLRKLDLSSNSIC 783
Cdd:cd21340 117 ALSNSL------RVLNISGNNIDSlEPLAPLR-------NLEQLDASNNQISD--LEELLDLLSSWPSLRELDLTGNPVC 181
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
221-365 |
9.37e-03 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 38.12 E-value: 9.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 221 PRVTVLLGKAGMGKTTLAHRLCqkwaeGHLNCFQALFLF---EFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEK 297
Cdd:smart00382 2 GEVILIVGPPGSGKTTLARALA-----RELGPPGGGVIYidgEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARK 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1864245117 298 NADQVLLIfdglDEA--LQPMGPDGPGPVLTLFSHLCNGTLLPGCRVMATSRPGKlpacLPAEAAMVHML 365
Cdd:smart00382 77 LKPDVLIL----DEItsLLDAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEK----DLGPALLRRRF 138
|
|
| |
