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Conserved domains on  [gi|1926855946|ref|NP_001375362|]
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coronin-6 isoform 3 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-465 5.11e-108

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 329.16  E-value: 5.11e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946   9 SKFRHVFGQAAKADQAYEDIRVSKVTWD-SSFCAVNPKFLAIIVEAGGGGAfiVLPLAKTGRVDKNYPLVTGHTAPVLDI 87
Cdd:PTZ00421    4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946  88 DWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTG--- 164
Cdd:PTZ00421   82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGkav 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 165 EVLLSlddmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAErFAAHEGMRPMRAVFT-RQGHIFTTGFTRMSQ 243
Cdd:PTZ00421  162 EVIKC----HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSS-VEAHASAKSQRCLWAkRKDLIITLGCSKSQQ 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 244 RELGLWDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPPFVHYlnTFSSKEPQRGMGFMPK 323
Cdd:PTZ00421  237 RQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPK 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 324 RGLDVSKCEIARFYKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLR---DGYVPP 398
Cdd:PTZ00421  315 WSLDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSavfDGTSPE 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 399 KHRELRVTKRNI---LDVRPPSGPRRSQSASDAPLSQHT--------------LETLLEEIKALRERVQAQEQRITALEN 461
Cdd:PTZ00421  395 LMGASALSPSGKprhSGVSVPASTSAMTHSFDDNTSKHAdpcamgvkrmdegiLDERLGRLQALSEKLRTQHEEIKRCRE 474


                  ....
gi 1926855946 462 MLCE 465
Cdd:PTZ00421  475 ALQK 478
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-465 5.11e-108

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 329.16  E-value: 5.11e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946   9 SKFRHVFGQAAKADQAYEDIRVSKVTWD-SSFCAVNPKFLAIIVEAGGGGAfiVLPLAKTGRVDKNYPLVTGHTAPVLDI 87
Cdd:PTZ00421    4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946  88 DWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTG--- 164
Cdd:PTZ00421   82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGkav 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 165 EVLLSlddmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAErFAAHEGMRPMRAVFT-RQGHIFTTGFTRMSQ 243
Cdd:PTZ00421  162 EVIKC----HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSS-VEAHASAKSQRCLWAkRKDLIITLGCSKSQQ 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 244 RELGLWDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPPFVHYlnTFSSKEPQRGMGFMPK 323
Cdd:PTZ00421  237 RQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPK 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 324 RGLDVSKCEIARFYKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLR---DGYVPP 398
Cdd:PTZ00421  315 WSLDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSavfDGTSPE 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 399 KHRELRVTKRNI---LDVRPPSGPRRSQSASDAPLSQHT--------------LETLLEEIKALRERVQAQEQRITALEN 461
Cdd:PTZ00421  395 LMGASALSPSGKprhSGVSVPASTSAMTHSFDDNTSKHAdpcamgvkrmdegiLDERLGRLQALSEKLRTQHEEIKRCRE 474


                  ....
gi 1926855946 462 MLCE 465
Cdd:PTZ00421  475 ALQK 478
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 3.91e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 124.92  E-value: 3.91e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1926855946   4 RVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFIVLPLAKTGR 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 78-296 6.15e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.21  E-value: 6.15e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946  78 TGHTAPVLDIDWCPHnDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 157
Cdd:cd00200    48 KGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLET-------GECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIK 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 158 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmrPMRAV--FTRQGHIFT 235
Cdd:cd00200   119 VWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA-TLTGHTG--EVNSVafSPDGEKLLS 194

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1926855946 236 TGftrmSQRELGLWDPNNFEEPVALQEMDtsNGVLLPFYDPDSSIVyLCGKGDSSIRYFEI 296
Cdd:cd00200   195 SS----SDGTIKLWDLSTGKCLGTLRGHE--NGVNSVAFSPDGYLL-ASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
77-292 2.19e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 2.19e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946  77 VTGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVI 156
Cdd:COG2319   200 LTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT-------GKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTV 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 157 IIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAErFAAHEGmRPMRAVFTRQGHIFTT 236
Cdd:COG2319   271 RLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT-LTGHTG-AVRSVAFSPDGKTLAS 347

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1926855946 237 GFtrmSQRELGLWDPNNFEEPVALQemDTSNGVLLPFYDPDSSIVYLCGkGDSSIR 292
Cdd:COG2319   348 GS---DDGTVRLWDLATGELLRTLT--GHTGAVTSVAFSPDGRTLASGS-ADGTVR 397
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 78-109 2.25e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.25e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1926855946   78 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVW 109
Cdd:smart00320   9 KGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-465 5.11e-108

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 329.16  E-value: 5.11e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946   9 SKFRHVFGQAAKADQAYEDIRVSKVTWD-SSFCAVNPKFLAIIVEAGGGGAfiVLPLAKTGRVDKNYPLVTGHTAPVLDI 87
Cdd:PTZ00421    4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946  88 DWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTG--- 164
Cdd:PTZ00421   82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGkav 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 165 EVLLSlddmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAErFAAHEGMRPMRAVFT-RQGHIFTTGFTRMSQ 243
Cdd:PTZ00421  162 EVIKC----HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSS-VEAHASAKSQRCLWAkRKDLIITLGCSKSQQ 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 244 RELGLWDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPPFVHYlnTFSSKEPQRGMGFMPK 323
Cdd:PTZ00421  237 RQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPK 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 324 RGLDVSKCEIARFYKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLR---DGYVPP 398
Cdd:PTZ00421  315 WSLDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSavfDGTSPE 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 399 KHRELRVTKRNI---LDVRPPSGPRRSQSASDAPLSQHT--------------LETLLEEIKALRERVQAQEQRITALEN 461
Cdd:PTZ00421  395 LMGASALSPSGKprhSGVSVPASTSAMTHSFDDNTSKHAdpcamgvkrmdegiLDERLGRLQALSEKLRTQHEEIKRCRE 474


                  ....
gi 1926855946 462 MLCE 465
Cdd:PTZ00421  475 ALQK 478
PTZ00420 PTZ00420
coronin; Provisional
 21-408 1.71e-69

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 231.38  E-value: 1.71e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946  21 ADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFIVLPLAKTGRvdkNYPLVT--GHTAPVLDIDWCPHNDNVIA 98
Cdd:PTZ00420   15 SNNLFDDLRICSRVIDSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR---KPPVIKlkGHTSSILDLQFNPCFSEILA 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946  99 SASDDTTIMVWQIP-DYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLddMHPDV 177
Cdd:PTZ00420   92 SGSEDLTIRVWEIPhNDESVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQI--NMPKK 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 178 IHSVCWNSNGSLLATTCKDKTLRIIDPRKgQVVAERFAAHEGMRPMRAVFT-----RQGHIFTTGFTRMSQRELGLWDPN 252
Cdd:PTZ00420  170 LSSLKWNIKGNLLSGTCVGKHMHIIDPRK-QEIASSFHIHDGGKNTKNIWIdglggDDNYILSTGFSKNNMREMKLWDLK 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 253 NFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPpfVHYLNTFSSKEPQRGMGFMPKRGLDVSKCE 332
Cdd:PTZ00420  249 NTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDVYKCE 326

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1926855946 333 IARFYK-LHERKCEPIIMTVPRK-SDLFQDDLYPDTPGPEPALEADEWLSGQDAEPVLISLRDgyvpPKHRELRVTKR 408
Cdd:PTZ00420  327 IGRVYKnENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKD----LTEDDLRITKK 400
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 3.91e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 124.92  E-value: 3.91e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1926855946   4 RVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFIVLPLAKTGR 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 78-296 6.15e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.21  E-value: 6.15e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946  78 TGHTAPVLDIDWCPHnDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 157
Cdd:cd00200    48 KGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLET-------GECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIK 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 158 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmrPMRAV--FTRQGHIFT 235
Cdd:cd00200   119 VWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA-TLTGHTG--EVNSVafSPDGEKLLS 194

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1926855946 236 TGftrmSQRELGLWDPNNFEEPVALQEMDtsNGVLLPFYDPDSSIVyLCGKGDSSIRYFEI 296
Cdd:cd00200   195 SS----SDGTIKLWDLSTGKCLGTLRGHE--NGVNSVAFSPDGYLL-ASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
77-292 2.19e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 2.19e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946  77 VTGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVI 156
Cdd:COG2319   200 LTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLAT-------GKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTV 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 157 IIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAErFAAHEGmRPMRAVFTRQGHIFTT 236
Cdd:COG2319   271 RLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT-LTGHTG-AVRSVAFSPDGKTLAS 347

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1926855946 237 GFtrmSQRELGLWDPNNFEEPVALQemDTSNGVLLPFYDPDSSIVYLCGkGDSSIR 292
Cdd:COG2319   348 GS---DDGTVRLWDLATGELLRTLT--GHTGAVTSVAFSPDGRTLASGS-ADGTVR 397
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 78-295 9.23e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 109.35  E-value: 9.23e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946  78 TGHTAPVLDIDWCPHNDnVIASASDDTTIMVWQIPDYtpmrnitEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 157
Cdd:cd00200    90 TGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETG-------KCLTTLRGHTDWVNSVAFSPDGT-FVASSSQDGTIK 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 158 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAErFAAHEGmRPMRAVFTRQGHIFTTG 237
Cdd:cd00200   161 LWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT-LRGHEN-GVNSVAFSPDGYLLASG 237

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1926855946 238 FtrmSQRELGLWDPNNFEEPVALQEmdTSNGVLLPFYDPDSSIVYLCGKgDSSIRYFE 295
Cdd:cd00200   238 S---EDGTIRVWDLRTGECVQTLSG--HTNSVTSLAWSPDGKRLASGSA-DGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
78-298 1.05e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.54  E-value: 1.05e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946  78 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 157
Cdd:COG2319   117 TGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLAT-------GKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVR 187

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 158 IWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmRPMRAVFTRQGHIFTTG 237
Cdd:COG2319   188 LWDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR-TLTGHSG-SVRSVAFSPDGRLLASG 264

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1926855946 238 ftrMSQRELGLWDPNNFEEPVALQemDTSNGVLLPFYDPDSSIVyLCGKGDSSIRYFEITD 298
Cdd:COG2319   265 ---SADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLAT 319
WD40 COG2319
WD40 repeat [General function prediction only];
77-292 2.06e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 2.06e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946  77 VTGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVI 156
Cdd:COG2319    74 LLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLAT-------GLLLRTLTGHTGAVRSVAFSPDGK-TLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 157 IIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmRPMRAVFTRQGHIFTT 236
Cdd:COG2319   145 RLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR-TLTGHTG-AVRSVAFSPDGKLLAS 221

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1926855946 237 GFtrmSQRELGLWDPNNFEEPVALQemDTSNGVLLPFYDPDSSIVYLCGkGDSSIR 292
Cdd:COG2319   222 GS---ADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFSPDGRLLASGS-ADGTVR 271
WD40 COG2319
WD40 repeat [General function prediction only];
76-205 2.25e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 2.25e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946  76 LVTGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDYTPMRnitepiiTLEGHSKRVGILSWHPTARnVLLSAGGDNV 155
Cdd:COG2319   283 TLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLR-------TLTGHTGAVRSVAFSPDGK-TLASGSDDGT 353

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1926855946 156 IIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIIDPR 205
Cdd:COG2319   354 VRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 344-386 1.57e-20

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 84.49  E-value: 1.57e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1926855946 344 CEPIIMTVPRKS-DLFQDDLYPDTPGPEPALEADEWLSGQDAEP 386
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 123-292 4.43e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.39  E-value: 4.43e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 123 PIITLEGHSKRVGILSWHPTaRNVLLSAGGDNVIIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRII 202
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 203 DPRKGQVVAErFAAHEGmrPMRAV-FTRQGHIFTTGftrMSQRELGLWDPNNFEEPVALQemDTSNGVLLPFYDPDSSIV 281
Cdd:cd00200    79 DLETGECVRT-LTGHTS--YVSSVaFSPDGRILSSS---SRDKTIKVWDVETGKCLTTLR--GHTDWVNSVAFSPDGTFV 150

                         170
                  ....*....|.
gi 1926855946 282 YlCGKGDSSIR 292
Cdd:cd00200   151 A-SSSQDGTIK 160
WD40 COG2319
WD40 repeat [General function prediction only];
78-163 3.95e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.55  E-value: 3.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946  78 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVWQIPDytpmrniTEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVII 157
Cdd:COG2319   327 TGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLAT-------GELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVR 397


                  ....*.
gi 1926855946 158 IWNVGT 163
Cdd:COG2319   398 LWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 174-298 7.80e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 7.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 174 HPDVIHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVVAeRFAAHEGmrPMRAV-FTRQGH-IFTTGFTRMSQrelgLWDP 251
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-TLKGHTG--PVRDVaASADGTyLASGSSDKTIR----LWDL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1926855946 252 NNFEEPVALqEMDTSnGVLLPFYDPDSSIVyLCGKGDSSIRYFEITD 298
Cdd:cd00200    81 ETGECVRTL-TGHTS-YVSSVAFSPDGRIL-SSSSRDKTIKVWDVET 124
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 78-109 2.25e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.25e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1926855946   78 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVW 109
Cdd:smart00320   9 KGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 163-203 4.27e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 4.27e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1926855946  163 TGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDKTLRIID 203
Cdd:smart00320   1 SGELLKTLKG-HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 89-186 1.08e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 43.81  E-value: 1.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946  89 WCPHNDnVIASASDDTTI--------MVWQIPdytpmrnitepiitLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWN 160
Cdd:pfam12894   3 WCPTMD-LIALATEDGELllhrlnwqRVWTLS--------------PDKEDLEVTSLAWRPDGK-LLAVGYSDGTVRLLD 66

                          90       100
                  ....*....|....*....|....*.
gi 1926855946 161 VGTGEVLLSLdDMHPDVIHSVCWNSN 186
Cdd:pfam12894  67 AENGKIVHHF-SAGSDLITCLGWGEN 91
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 122-160 1.45e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.45e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1926855946  122 EPIITLEGHSKRVGILSWHPTaRNVLLSAGGDNVIIIWN 160
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
78-109 2.71e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.71e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1926855946  78 TGHTAPVLDIDWCPhNDNVIASASDDTTIMVW 109
Cdd:pfam00400   8 EGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
174-203 1.53e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.53e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1926855946 174 HPDVIHSVCWNSNGSLLATTCKDKTLRIID 203
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
122-160 1.58e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.58e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1926855946 122 EPIITLEGHSKRVGILSWHPTaRNVLLSAGGDNVIIIWN 160
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
118-253 2.74e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.89  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926855946 118 RNITEPIITLEGHSKRVGILSWHPTARnVLLSAGGDNVIIIWNVGTGEVLLSLDDmHPDVIHSVCWNSNGSLLATTCKDK 197
Cdd:COG2319    23 AALGALLLLLLGLAAAVASLAASPDGA-RLAAGAGDLTLLLLDAAAGALLATLLG-HTAAVLSVAFSPDGRLLASASADG 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1926855946 198 TLRIIDPRKGQVVAeRFAAHEGmRPMRAVFTRQGHIFTTGFtrmSQRELGLWDPNN 253
Cdd:COG2319   101 TVRLWDLATGLLLR-TLTGHTG-AVRSVAFSPDGKTLASGS---ADGTVRLWDLAT 151
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 178-210 4.59e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.49  E-value: 4.59e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1926855946 178 IHSVCWNSNGSLLATTCKDKTLRIIDPRKGQVV 210
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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