TASPase homolog [Caenorhabditis elegans]
Protein Classification
threonine aspartase 1( domain architecture ID 10139957)
threonine aspartase 1 (also known as taspase-1) is protease which cleaves the mixed-lineage leukemia (MLL) and transcription factor (TF) IIA families of nuclear proteins
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| Taspase1_like | cd04514 | Taspase 1 (threonine aspartase 1) and similar proteins; Taspase1 catalyzes the cleavage of the ... |
5-304 | 4.10e-72 | ||||||
Taspase 1 (threonine aspartase 1) and similar proteins; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A threonine residue acts as the active site nucleophile in both endopeptidease and protease activities to cleave polypeptide substrates after an aspartate residue. The Taspase1 proenzyme undergoes autoproteolysis into alpha and beta subunits. The N-terminal residue of the beta subunit is a threonine which is the active catalytic residue. The active enzyme is a heterotetramer. : Pssm-ID: 271336 Cd Length: 313 Bit Score: 226.00 E-value: 4.10e-72
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| Name | Accession | Description | Interval | E-value | ||||||
| Taspase1_like | cd04514 | Taspase 1 (threonine aspartase 1) and similar proteins; Taspase1 catalyzes the cleavage of the ... |
5-304 | 4.10e-72 | ||||||
Taspase 1 (threonine aspartase 1) and similar proteins; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A threonine residue acts as the active site nucleophile in both endopeptidease and protease activities to cleave polypeptide substrates after an aspartate residue. The Taspase1 proenzyme undergoes autoproteolysis into alpha and beta subunits. The N-terminal residue of the beta subunit is a threonine which is the active catalytic residue. The active enzyme is a heterotetramer. Pssm-ID: 271336 Cd Length: 313 Bit Score: 226.00 E-value: 4.10e-72
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| PLN02937 | PLN02937 | Putative isoaspartyl peptidase/L-asparaginase |
7-240 | 1.72e-27 | ||||||
Putative isoaspartyl peptidase/L-asparaginase Pssm-ID: 215506 [Multi-domain] Cd Length: 414 Bit Score: 111.11 E-value: 1.72e-27
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| Asparaginase_2 | pfam01112 | Asparaginase; |
6-241 | 2.25e-24 | ||||||
Asparaginase; Pssm-ID: 426055 Cd Length: 308 Bit Score: 100.74 E-value: 2.25e-24
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| Name | Accession | Description | Interval | E-value | ||||||
| Taspase1_like | cd04514 | Taspase 1 (threonine aspartase 1) and similar proteins; Taspase1 catalyzes the cleavage of the ... |
5-304 | 4.10e-72 | ||||||
Taspase 1 (threonine aspartase 1) and similar proteins; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A threonine residue acts as the active site nucleophile in both endopeptidease and protease activities to cleave polypeptide substrates after an aspartate residue. The Taspase1 proenzyme undergoes autoproteolysis into alpha and beta subunits. The N-terminal residue of the beta subunit is a threonine which is the active catalytic residue. The active enzyme is a heterotetramer. Pssm-ID: 271336 Cd Length: 313 Bit Score: 226.00 E-value: 4.10e-72
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| ASRGL1_like | cd04702 | Metazoan L-Asparaginase type 2; ASRGL1 and similar proteins constitute a subfamily of the ... |
6-237 | 1.10e-33 | ||||||
Metazoan L-Asparaginase type 2; ASRGL1 and similar proteins constitute a subfamily of the L-Asparaginase type 2-like enzymes. The wider family includes Glycosylasparaginase, Taspase 1, and L-Asparaginase type 2 enzymes. The proenzymes undergo autoproteolytic cleavage before a threonine to generate alpha and beta subunits. The threonine becomes the N-terminal residue of the beta subunit and is the catalytic residue. ASRGL1, or asparaginase-like 1, has been cloned from mammalian testis cDNA libraries. It has been identified as a sperm antigen that may induce the production of autoantibodies following obstruction of the male reproductive tract, e.g. vasectomy. Pssm-ID: 271338 Cd Length: 289 Bit Score: 125.38 E-value: 1.10e-33
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| Ntn_Asparaginase_2_like | cd04512 | L-Asparaginase type 2-like enzymes of the NTN-hydrolase superfamily; This family includes ... |
6-241 | 1.07e-29 | ||||||
L-Asparaginase type 2-like enzymes of the NTN-hydrolase superfamily; This family includes Glycosylasparaginase, Taspase 1, and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoprotein. Taspase1 catalyzes the cleavage of the Mix Lineage Leukemia (MLL) nuclear protein and transcription factor TFIIA. L-Asparaginase type 2 hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzymes of this family undergo autoproteolytic cleavage before a threonine to generate alpha and beta subunits. The threonine becomes the N-terminal residue of the beta subunit and is the catalytic residue. The family is circularly permuted relative to other NTN-hydrolase families. Pssm-ID: 271334 Cd Length: 249 Bit Score: 113.82 E-value: 1.07e-29
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| PLN02937 | PLN02937 | Putative isoaspartyl peptidase/L-asparaginase |
7-240 | 1.72e-27 | ||||||
Putative isoaspartyl peptidase/L-asparaginase Pssm-ID: 215506 [Multi-domain] Cd Length: 414 Bit Score: 111.11 E-value: 1.72e-27
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| Asparaginase_2 | pfam01112 | Asparaginase; |
6-241 | 2.25e-24 | ||||||
Asparaginase; Pssm-ID: 426055 Cd Length: 308 Bit Score: 100.74 E-value: 2.25e-24
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| Asparaginase_2 | cd04701 | Bacterial/fungal L-Asparaginase type 2; L-Asparaginase hydrolyzes L-asparagine to L-aspartate ... |
7-241 | 3.42e-24 | ||||||
Bacterial/fungal L-Asparaginase type 2; L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta subunit. The threonine residue plays a central role in hydrolase activity. Some asparaginases can also hydrolyze L-glutamine and are termed glutaminase-asparaginase. This is a member of the Ntn-hydrolase superfamily, and this subfamily covers mostly bacterial and fungal enzymes. Pssm-ID: 271337 Cd Length: 264 Bit Score: 99.07 E-value: 3.42e-24
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| Asparaginase_2_like_1 | cd04703 | Uncharacterized subfamily of the L-Asparaginase type 2-like enzymes, an Ntn-hydrolase family; ... |
6-273 | 1.49e-22 | ||||||
Uncharacterized subfamily of the L-Asparaginase type 2-like enzymes, an Ntn-hydrolase family; The wider family of Asparaginase 2-like enzymes includes Glycosylasparaginase, Taspase 1, and L-Asparaginase type 2. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoprotein. Taspase1 catalyzes the cleavage of the Mix Lineage Leukemia (MLL) nuclear protein and transcription factor TFIIA. L-Asparaginase type 2 hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzymes of this family undergo autoproteolytic cleavage before a threonine to generate alpha and beta subunits. The threonine becomes the N-terminal residue of the beta subunit and is the catalytic residue. Pssm-ID: 271339 Cd Length: 243 Bit Score: 94.25 E-value: 1.49e-22
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| PLN02689 | PLN02689 | Bifunctional isoaspartyl peptidase/L-asparaginase |
7-275 | 3.81e-19 | ||||||
Bifunctional isoaspartyl peptidase/L-asparaginase Pssm-ID: 215372 Cd Length: 318 Bit Score: 86.30 E-value: 3.81e-19
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| Glycosylasparaginase | cd04513 | Glycosylasparaginase and similar proteins; Glycosylasparaginase catalyzes the hydrolysis of ... |
34-197 | 7.79e-18 | ||||||
Glycosylasparaginase and similar proteins; Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU). The glycosylasparaginase precursor undergoes autoproteolysis through an N-O or N-S acyl rearrangement of the peptide bond, which leads to the cleavage of a peptide bond between an Asp and a Thr. This proteolysis step generates an exposed N-terminal catalytic threonine and activates the enzyme. Pssm-ID: 271335 Cd Length: 294 Bit Score: 82.22 E-value: 7.79e-18
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| PRK10226 | PRK10226 | isoaspartyl peptidase; Provisional |
6-286 | 2.86e-15 | ||||||
isoaspartyl peptidase; Provisional Pssm-ID: 182319 Cd Length: 313 Bit Score: 75.37 E-value: 2.86e-15
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| Asparaginase_2_like_3 | cd14949 | Uncharacterized bacterial subfamily of the L-Asparaginase type 2-like enzymes, an ... |
33-273 | 2.13e-13 | ||||||
Uncharacterized bacterial subfamily of the L-Asparaginase type 2-like enzymes, an Ntn-hydrolase family; The wider family of Asparaginase 2-like enzymes includes Glycosylasparaginase, Taspase 1, and L-Asparaginase type 2. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoprotein. Taspase1 catalyzes the cleavage of the Mix Lineage Leukemia (MLL) nuclear protein and transcription factor TFIIA. L-Asparaginase type 2 hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzymes of this family undergo autoproteolytic cleavage before a threonine to generate alpha and beta subunits. The threonine becomes the N-terminal residue of the beta subunit and is the catalytic residue. Pssm-ID: 271340 Cd Length: 280 Bit Score: 69.17 E-value: 2.13e-13
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