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Conserved domains on  [gi|1972257463|ref|NP_001379537|]
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Rho-GAP domain-containing protein [Caenorhabditis elegans]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 10069020)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

CATH:  1.10.555.10
Gene Ontology:  GO:0007165|GO:0005096
PubMed:  17222083|12480336
SCOP:  4001255

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 41-214 5.49e-29

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


:

Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 109.70  E-value: 5.49e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  41 PATLLMLLLKVNKDGPAKKDIWRAPGNQAQVRKLSQVMQHGR-LVNIENFTVYTAASVIKKFLSKLPNGIFGRDNEEtLF 119
Cdd:cd00159     1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEdIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYD-EF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463 120 NSASTGMDIEKQRQVFYRIFGSLPVASQHLLVLLFGTFRVVADSSDghSNAMNPNAIAISVAPSLFHTCIHDgrtarVED 199
Cdd:cd00159    80 IELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSE--VNKMTASNLAIVFAPTLLRPPDSD-----DEL 152

                         170
                  ....*....|....*
gi 1972257463 200 LQRFKLASNIVCSII 214
Cdd:cd00159   153 LEDIKKLNEIVEFLI 167
 
Name Accession Description Interval E-value
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 41-214 5.49e-29

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 109.70  E-value: 5.49e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  41 PATLLMLLLKVNKDGPAKKDIWRAPGNQAQVRKLSQVMQHGR-LVNIENFTVYTAASVIKKFLSKLPNGIFGRDNEEtLF 119
Cdd:cd00159     1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEdIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYD-EF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463 120 NSASTGMDIEKQRQVFYRIFGSLPVASQHLLVLLFGTFRVVADSSDghSNAMNPNAIAISVAPSLFHTCIHDgrtarVED 199
Cdd:cd00159    80 IELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSE--VNKMTASNLAIVFAPTLLRPPDSD-----DEL 152

                         170
                  ....*....|....*
gi 1972257463 200 LQRFKLASNIVCSII 214
Cdd:cd00159   153 LEDIKKLNEIVEFLI 167
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 41-187 1.32e-23

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 94.92  E-value: 1.32e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  41 PATLLMLLLKVNKDGPAKKDIWRAPGNQAQVRKLSQVMQHGRLV--NIENFTVYTAASVIKKFLSKLPNGIFGRDNEETL 118
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVdlDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1972257463 119 FNSASTGMDIEKqRQVFYRIFGSLPVASQHLLVLLFGTFRVVADSSDghSNAMNPNAIAISVAPSLFHT 187
Cdd:pfam00620  81 IEAAKLPDEEER-LEALRELLRKLPPANRDTLRYLLAHLNRVAQNSD--VNKMNAHNLAIVFGPTLLRP 146
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 39-186 3.27e-18

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 80.77  E-value: 3.27e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463   39 DIPATLLMLLLKVNKDGPAKKDIWRAPGNQAQVRKLSQVMQHG--RLVNIENFTVYTAASVIKKFLSKLPNGIFGRDNEE 116
Cdd:smart00324   2 PIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGpdPDLDLSEYDVHDVAGLLKLFLRELPEPLITYELYE 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  117 TLFNSASTGMDIEKQRQVfYRIFGSLPVASQHLLVLLFGTFRVVADSSDghSNAMNPNAIAISVAPSLFH 186
Cdd:smart00324  82 EFIEAAKLEDETERLRAL-RELLSLLPPANRATLRYLLAHLNRVAEHSE--ENKMTARNLAIVFGPTLLR 148
 
Name Accession Description Interval E-value
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 41-214 5.49e-29

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 109.70  E-value: 5.49e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  41 PATLLMLLLKVNKDGPAKKDIWRAPGNQAQVRKLSQVMQHGR-LVNIENFTVYTAASVIKKFLSKLPNGIFGRDNEEtLF 119
Cdd:cd00159     1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEdIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYD-EF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463 120 NSASTGMDIEKQRQVFYRIFGSLPVASQHLLVLLFGTFRVVADSSDghSNAMNPNAIAISVAPSLFHTCIHDgrtarVED 199
Cdd:cd00159    80 IELAKIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSE--VNKMTASNLAIVFAPTLLRPPDSD-----DEL 152

                         170
                  ....*....|....*
gi 1972257463 200 LQRFKLASNIVCSII 214
Cdd:cd00159   153 LEDIKKLNEIVEFLI 167
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 41-187 1.32e-23

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 94.92  E-value: 1.32e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  41 PATLLMLLLKVNKDGPAKKDIWRAPGNQAQVRKLSQVMQHGRLV--NIENFTVYTAASVIKKFLSKLPNGIFGRDNEETL 118
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVdlDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1972257463 119 FNSASTGMDIEKqRQVFYRIFGSLPVASQHLLVLLFGTFRVVADSSDghSNAMNPNAIAISVAPSLFHT 187
Cdd:pfam00620  81 IEAAKLPDEEER-LEALRELLRKLPPANRDTLRYLLAHLNRVAQNSD--VNKMNAHNLAIVFGPTLLRP 146
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 39-186 3.27e-18

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 80.77  E-value: 3.27e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463   39 DIPATLLMLLLKVNKDGPAKKDIWRAPGNQAQVRKLSQVMQHG--RLVNIENFTVYTAASVIKKFLSKLPNGIFGRDNEE 116
Cdd:smart00324   2 PIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGpdPDLDLSEYDVHDVAGLLKLFLRELPEPLITYELYE 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  117 TLFNSASTGMDIEKQRQVfYRIFGSLPVASQHLLVLLFGTFRVVADSSDghSNAMNPNAIAISVAPSLFH 186
Cdd:smart00324  82 EFIEAAKLEDETERLRAL-RELLSLLPPANRATLRYLLAHLNRVAEHSE--ENKMTARNLAIVFGPTLLR 148
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 28-219 1.07e-15

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 74.26  E-value: 1.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  28 FGVPINEAFA-HDIPATLLMLLLKVNKDGPAKKDIWRAPGNQAQVRKLSQVMQHGRLVNIENFTVYTAASVIKKFLSKLP 106
Cdd:cd04402     2 FGQPLSNICEdDNLPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNIP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463 107 NGIFGRDNEETLFNSASTGMDIEKQRQVfYRIFGSLPVASQHLLVLLFGTFRVVADSSdgHSNAMNPNAIAISVAPSLFH 186
Cdd:cd04402    82 GSLLSSDLYEEWMSALDQENEEEKIAEL-QRLLDKLPRPNVLLLKHLICVLHNISQNS--ETNKMDAFNLAVCIAPSLLW 158

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1972257463 187 ---TCIHDGR-TARVEDLQRFkLASNivCSIIcsFGD 219
Cdd:cd04402   159 ppaSSELQNEdLKKVTSLVQF-LIEN--CQEI--FGE 190
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 28-187 7.22e-13

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 66.31  E-value: 7.22e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  28 FGVPINEAFA--HDIPATLLMLLLKVNKDGPAKKDIWRAPGNQAQVRKLSQVMQHG-RLVNIENFTVYTAASVIKKFLSK 104
Cdd:cd04377     1 FGVSLSSLTSedRSVPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDpDSVNLEDYPIHVITSVLKQWLRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463 105 LPNGIFGRDNEETlFNSASTGMDIEKQRQVFYRIFGSLPVASQHLL-VLLFGTFRVvADSSDghSNAMNPNAIAISVAPS 183
Cdd:cd04377    81 LPEPLMTFELYEN-FLRAMELEEKQERVRALYSVLEQLPRANLNTLeRLIFHLVRV-ALQEE--VNRMSANALAIVFAPC 156


                  ....
gi 1972257463 184 LFHT 187
Cdd:cd04377   157 ILRC 160
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 28-185 5.02e-12

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 63.86  E-value: 5.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  28 FGVPINEAFAH--DIPATLLMLLLKVNKDGPAKKDIWRAPGNQAQVRKLSQVMQHG-RLVNIENFTVYTAASVIKKFLSK 104
Cdd:cd04407     1 FGVRVGSLTSNktSVPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADpENVKLENYPIHAITGLLKQWLRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463 105 LPNGIFgrdnEETLFNSASTGMDI-EKQRQV--FYRIFGSLPVASQHLLVLLFgtFRVVADSSDGHSNAMNPNAIAISVA 181
Cdd:cd04407    81 LPEPLM----TFAQYNDFLRAVELpEKQEQLqaIYRVLEQLPTANHNTLERLI--FHLVKVALEEDVNRMSPNALAIVFA 154


                  ....
gi 1972257463 182 PSLF 185
Cdd:cd04407   155 PCLL 158
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 28-215 2.73e-11

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 62.36  E-value: 2.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  28 FGVPINEAFAHD--------IPATLLMLLLKVNKDGPAKKDIWRAPGNQAQVRKLSQVMQ---HGRLVNIENFTVYTAAS 96
Cdd:cd04391     2 FGVPLSTLLERDqkkvpgskVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEakfYEGTFLWDQVKQHDAAS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  97 VIKKFLSKLPNGIFGRDNEETlFNSASTGMDIEKQRQVFYRIFGSLPVASQHLLVLLFGTFRVVADSSDghSNAMNPNAI 176
Cdd:cd04391    82 LLKLFIRELPQPLLTVEYLPA-FYSVQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEE--KNKMNLWNV 158

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1972257463 177 AISVAPSLFhTCIHDGRTARVEDLQRFKLAsNIVCSIIC 215
Cdd:cd04391   159 AMIMAPNLF-PPRGKHSKDNESLQEEVNMA-AGCANIMR 195
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 28-214 6.72e-08

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 52.08  E-value: 6.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  28 FGVPINE-----AFAHDIPATLLMLLLKVNKDGPAKKDIWRAPGNQAQVRKLSQVMQHGRLVNIENFT-VYTAASVIKKF 101
Cdd:cd04393     3 FGVPLQElqqagQPENGVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEAdVCSAASLLRLF 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463 102 LSKLPNGIF-GRDNEETLFNSASTGMDIEKQRQVFYrIFGSLPVASQHLLVLLFGTFRVVAdsSDGHSNAMNPNAIAISV 180
Cdd:cd04393    83 LQELPEGLIpASLQIRLMQLYQDYNGEDEFGRKLRD-LLQQLPPVNYSLLKFLCHFLSNVA--SQHHENRMTAENLAAVF 159

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1972257463 181 APSLFHTcihdgrTARVEDLQRFKLASNIVCSII 214
Cdd:cd04393   160 GPDVFHV------YTDVEDMKEQEICSRIMAKLL 187
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 61-187 9.90e-08

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 51.54  E-value: 9.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  61 IWRAPGNQAQVRKL-SQVMQHGRLVNI-EN-FTVYTAASVIKKFLSKLPNGIFGRDNEETLFNSAStgMDIEKQRQVFYR 137
Cdd:cd04385    36 IYRKNGKNSSVKKLlEAFRKDARSVQLrEGeYTVHDVADVLKRFLRDLPDPLLTSELHAEWIEAAE--LENKDERIARYK 113

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1972257463 138 IF-GSLPVASQHLLVLLFGTFRVVADSSDghSNAMNPNAIAISVAPSLFHT 187
Cdd:cd04385   114 ELiRRLPPINRATLKVLIGHLYRVQKHSD--ENQMSVHNLALVFGPTLFQT 162
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 28-185 1.44e-07

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 50.92  E-value: 1.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  28 FGVPIN--EAFAHDIPATLLMLLLKVNKDGPAKKDIWRAPGNQAQVRKL-SQVMQHGRL-VNIENFTVYTAASVIKKFLS 103
Cdd:cd04373     1 FGVPLAnvVTSEKPIPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLqKQFDQDHNLdLVSKDFTVNAVAGALKSFFS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463 104 KLPNGIFGRDNEETLFnSASTGMDIEKQRQVFYRIFGSLPVASQHLLVLLFGTFRVVADSSdgHSNAMNPNAIAISVAPS 183
Cdd:cd04373    81 ELPDPLIPYSMHLELV-EAAKINDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNS--KVNLMTSENLSICFWPT 157


                  ..
gi 1972257463 184 LF 185
Cdd:cd04373   158 LM 159
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 28-186 2.49e-07

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 50.88  E-value: 2.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  28 FGVP---INEAFAHDIPATLLMLLLKVNKDGPAKKDIWRAPGNQAQVRKL-SQVMQHGRLVNIENFTVYTAASVIKKFLS 103
Cdd:cd04375     5 FGVPllvNLQRTGQPLPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLrSMIESSTDNVNYDGQQAYDVADMLKQYFR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463 104 KLPngifgrdneETLFNSastgmdieKQRQVFYRIFGSLPV-----ASQHLLVLLFGTFR------------VVADSSDg 166
Cdd:cd04375    85 DLP---------EPLLTN--------KLSETFIAIFQYVPKeqrleAVQCAILLLPDENRevlqtllyflsdVAANSQE- 146

                         170       180
                  ....*....|....*....|
gi 1972257463 167 hsNAMNPNAIAISVAPSLFH 186
Cdd:cd04375   147 --NQMTATNLAVCLAPSLFH 164
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 28-184 2.86e-07

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 50.13  E-value: 2.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  28 FGVPINEAFAH-------DIPATLLMLLLKVNKDGPAKKDIWRAPGNQAQVRKLSQVMQHGRLVNIENFTVYTAASVIKK 100
Cdd:cd04381     1 FGASLSLAVERsrchdgiDLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLEEYEPPTVASLLKQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463 101 FLSKLPNGIFGRDnEETLFNSASTGMDIEKQRQVFYRIFGSLPVASQHLLVLLFGTF-RVVADSSDghsNAMNPNAIAIS 179
Cdd:cd04381    81 YLRELPEPLLTKE-LMPRFEEACGRPTEAEREQELQRLLKELPECNRLLLAWLIVHMdHVIAQELE---TKMNIQNISIV 156


                  ....*
gi 1972257463 180 VAPSL 184
Cdd:cd04381   157 LSPTV 161
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 28-185 3.79e-07

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 49.61  E-value: 3.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  28 FGVPINEAFAHD--IPATLLMLLLKVNKDGPAKKDIWRAPGNQAQVRKLSQVMQ-HGRLVNIENFTVYTAASVIKKFLSK 104
Cdd:cd04406     1 FGVELSRLTSEDrsVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDtDANSVNLDDYNIHVIASVFKQWLRD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463 105 LPNGIFGRDneetLFNSASTGMDIEKQRQVFYRIFGSLPVASQ-HLLVLLFGTFRVVADSSDGHSNAMNPNAIAISVAPS 183
Cdd:cd04406    81 LPNPLMTFE----LYEEFLRAMGLQERRETVRGVYSVIDQLSRtHLNTLERLIFHLVRIALQEETNRMSANALAIVFAPC 156


                  ..
gi 1972257463 184 LF 185
Cdd:cd04406   157 IL 158
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 59-184 4.17e-07

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 49.73  E-value: 4.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  59 KDIWRAPGNQAQVRKLSQVMQHGR-LVNIENFTVYTAASVIKKFLSKLP---------NGIFG------RDNEEtlfnSA 122
Cdd:cd04378    35 QGIYRVSGSKARVEKLCQAFENGKdLVELSELSPHDISSVLKLFLRQLPeplilfrlyNDFIAlakeiqRDTEE----DK 110

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1972257463 123 STGMDIEKQRQVFY--RIFGSLPVAS----QHLLVLLFgtfRVVADSSDghsNAMNPNAIAISVAPSL 184
Cdd:cd04378   111 APNTPIEVNRIIRKlkDLLRQLPASNyntlQHLIAHLY---RVAEQFEE---NKMSPNNLGIVFGPTL 172
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 61-191 1.20e-06

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 48.95  E-value: 1.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  61 IWRAPGNQAQVRKLSQVM----QHGRLVNIENFTVYTAASVIKKFLSKLPNGIFGRDNEE------TLFNSASTGM---- 126
Cdd:cd04396    53 IFRVAGSSKRIRELQLIFstppDYGKSFDWDGYTVHDAASVLRRYLNNLPEPLVPLDLYEefrnplRKRPRILQYMkgri 132

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1972257463 127 ------DIEKQRQVFYRIFGSLPVASQHLLVLLFGTFRVVADSSDghSNAMNPNAIAISVAPSLFHTCIHD 191
Cdd:cd04396   133 neplntDIDQAIKEYRDLITRLPNLNRQLLLYLLDLLAVFARNSD--KNLMTASNLAAIFQPGILSHPDHE 201
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 61-186 2.12e-06

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 47.39  E-value: 2.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  61 IWRAPGNQAQVRKLSQVMQHGRLVNI-----ENFTVYTAAsvIKKFLSKLPNGIFgrdnEETLFNSASTGMDIEKQRQVF 135
Cdd:cd04403    37 IYRVSGNLAVIQKLRFAVDHDEKLDLddskwEDIHVITGA--LKLFFRELPEPLF----PYSLFNDFVAAIKLSDYEQRV 110

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1972257463 136 YRI---FGSLPVASQHLLVLLFGTFRVVADSSDghSNAMNPNAIAISVAPSLFH 186
Cdd:cd04403   111 SAVkdlIKSLPKPNHDTLKMLFRHLCRVIEHGE--KNRMTTQNLAIVFGPTLLR 162
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 28-184 3.44e-06

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 46.97  E-value: 3.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  28 FGVPINEAFA--------HDIPATL---LMLLLKvnKDGPAKKDIWRAPGNQAQVRKLSQVMQHGRLVNI----ENFTVY 92
Cdd:cd04400     2 FGSPLEEAVElsshkyngRDLPSVVyrcIEYLDK--NRAIYEEGIFRLSGSASVIKQLKERFNTEYDVDLfsssLYPDVH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  93 TAASVIKKFLSKLPNGIFGRDNEETLFNSASTGMDIEKQRQVFYRIFGSLPVASQHLLVLLFGTFRVVADSSDghSNAMN 172
Cdd:cd04400    80 TVAGLLKLYLRELPTLILGGELHNDFKRLVEENHDRSQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHSD--VNKMN 157

                         170
                  ....*....|..
gi 1972257463 173 PNAIAISVAPSL 184
Cdd:cd04400   158 LRNVCIVFSPTL 169
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 61-184 4.03e-06

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 46.73  E-value: 4.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  61 IWRAPGNQAQVRKLSQVMQHGR-LVNIENFTVYTAASVIKKFLSKLPNGI-----------FGRD---NEETLFNSASTG 125
Cdd:cd04408    37 IYRISGSKARVEKLCQAFENGRdLVDLSGHSPHDITSVLKHFLKELPEPVlpfqlyddfiaLAKElqrDSEKAAESPSIV 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463 126 MD-IEKQRQVFYRIFGSLPVASQHLLVLLFgtfRVVADSSDghsNAMNPNAIAISVAPSL 184
Cdd:cd04408   117 ENiIRSLKELLGRLPVSNYNTLRHLMAHLY---RVAERFED---NKMSPNNLGIVFGPTL 170
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 28-187 1.14e-05

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 45.47  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  28 FGVPINEA--FAHD-IPATLLMLLLKVNKDGPAKKDIWRAPGNQAQVRKL-SQVMQHGRLVNI---ENFT--VYTAASVI 98
Cdd:cd04398     1 FGVPLEDLilREGDnVPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLkELFDKDPLNVLLispEDYEsdIHSVASLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  99 KKFLSKLPNGIFgRDNEETLFNSASTGMDIEKQRQVFYRIFGSLPVASQHLL-VLLFGTFRVVADSSDghsNAMNPNAIA 177
Cdd:cd04398    81 KLFFRELPEPLL-TKALSREFIEAAKIEDESRRRDALHGLINDLPDANYATLrALMFHLARIKEHESV---NRMSVNNLA 156

                         170
                  ....*....|
gi 1972257463 178 ISVAPSLFHT 187
Cdd:cd04398   157 IIWGPTLMNA 166
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 28-187 1.65e-05

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 45.16  E-value: 1.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  28 FGVPINeAFAH-------DIPATLL----MLLLKVNKDGpakkdIWRAPGNQAQVRKLSQVMQHGRLVnIENFTVYTAAS 96
Cdd:cd04394     2 FGVPLH-SLPHstvpeygNVPKFLVdactFLLDHLSTEG-----LFRKSGSVVRQKELKAKLEGGEAC-LSSALPCDVAG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  97 VIKKFLSKLPNGIFGRDNEETLFNSASTGMDIEKQRQVfyrIFGSLPVASQHLLVL--LFGTFRVVADSSDghSNAMNPN 174
Cdd:cd04394    75 LLKQFFRELPEPLLPYDLHEALLKAQELPTDEERKSAT---LLLTCLLPDEHVNTLryFFSFLYDVAQRCS--ENKMDSS 149

                         170
                  ....*....|...
gi 1972257463 175 AIAISVAPSLFHT 187
Cdd:cd04394   150 NLAVIFAPNLFQS 162
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 28-187 1.07e-04

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 42.77  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  28 FGVPINEAFAHDIPATLLMLLLK----VNKDGPAKKDIWRAPGNQAQVRKLSQVMQHG-----------RLVNIenftvy 92
Cdd:cd04395     2 FGVPLDDCPPSSENPYVPLIVEVccniVEARGLETVGIYRVPGNNAAISALQEELNRGgfdidlqdprwRDVNV------ 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  93 tAASVIKKFLSKLPNGIFgRDNEETLFNSASTGMDIEKQRQVFYRIFGSLPVASQHLLVLLFGTFRVVADSSDghSNAMN 172
Cdd:cd04395    76 -VSSLLKSFFRKLPEPLF-TNELYPDFIEANRIEDPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSE--VNKME 151

                         170
                  ....*....|....*
gi 1972257463 173 PNAIAISVAPSLFHT 187
Cdd:cd04395   152 PRNLAIVFGPTLVRT 166
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 33-186 9.53e-04

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 39.71  E-value: 9.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  33 NEAFAHDIPATLLMLLLKVNKDGPAKKDIWRAPGNQAQVRKLSQVMQHGR--LVNIEN-FTVYTAASVIKKFLSKLPNGI 109
Cdd:cd04383    11 IQDSGQAIPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFERGEdpLADDQNdHDINSVAGVLKLYFRGLENPL 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1972257463 110 FGRDNEETLFNSASTGMDIEKQRQVfYRIFGSLPVASQHLLVLLFGTFRVVADSSDghSNAMNPNAIAISVAPSLFH 186
Cdd:cd04383    91 FPKERFEDLMSCVKLENPTERVHQI-REILSTLPRSVIIVMRYLFAFLNHLSQFSD--ENMMDPYNLAICFGPTLMP 164
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 28-184 1.06e-03

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 39.75  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  28 FGVPINEAFAHDIPATLLMLLLKVNKDGpakkdIWRAPGNQAQVRKLSQVMQHGRLVNIE--NFTVYTAASVIKKFLSKL 105
Cdd:cd04392     1 FGAPLTEEGIAQIYQLIEYLEKNLRVEG-----LFRKPGNSARQQELRDLLNSGTDLDLEsgGFHAHDCATVLKGFLGEL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463 106 PNGIFGRDN--------EETLFNSASTGMDIE-KQRQV--FYRIFGSLPVASQHLLVLLFGTFRVVADSSDghSNAMNPN 174
Cdd:cd04392    76 PEPLLTHAHypahlqiaDLCQFDEKGNKTSAPdKERLLeaLQLLLLLLPEENRNLLKLILDLLYQTAKHED--KNKMSAD 153

                         170
                  ....*....|
gi 1972257463 175 AIAISVAPSL 184
Cdd:cd04392   154 NLALLFTPHL 163
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 24-184 5.15e-03

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 37.82  E-value: 5.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  24 EKVKFGVPI-------NEAFAHDIPATLLMLLlkvnKDGPAKKDIWRAPGNQAQVRKLSQVM--QHGRLVNIENFT-VYT 93
Cdd:cd04386     1 EKPVFGTPLeehlkrtGREIALPIEACVMCLL----ETGMNEEGLFRVGGGASKLKRLKAALdaGTFSLPLDEFYSdPHA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972257463  94 AASVIKKFLSKLPNGIFgRDNEETLFNSASTGMDIEKQRQVFYRIFGSLPVASQHLLVLLFGTFRVVADSSDghSNAMNP 173
Cdd:cd04386    77 VASALKSYLRELPDPLL-TYNLYEDWVQAANKPDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSD--ENKMSP 153

                         170
                  ....*....|.
gi 1972257463 174 NAIAISVAPSL 184
Cdd:cd04386   154 SNIAIVLAPNL 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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