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Conserved domains on  [gi|1972308123|ref|NP_001379613|]
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HotDog ACOT-type domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TesB super family cl34379
Acyl-CoA thioesterase [Lipid transport and metabolism];
8-83 1.60e-06

Acyl-CoA thioesterase [Lipid transport and metabolism];


The actual alignment was detected with superfamily member COG1946:

Pssm-ID: 441549 [Multi-domain]  Cd Length: 273  Bit Score: 44.87  E-value: 1.60e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1972308123   8 ISAMLSIDNIDDNIYRSEGPHIGGIfgvNRLFGGYIAGQVYEAVRiykNKIKDENVIFSMHYNFVSAGDPRKLIDI 83
Cdd:COG1946     5 LLDLLDLERLEDGLFRGEISPDQGL---RRVFGGQVAAQALRAAR---RTVPEDRPPHSLHAYFLRPGDPDGPIEY 74
 
Name Accession Description Interval E-value
TesB COG1946
Acyl-CoA thioesterase [Lipid transport and metabolism];
8-83 1.60e-06

Acyl-CoA thioesterase [Lipid transport and metabolism];


Pssm-ID: 441549 [Multi-domain]  Cd Length: 273  Bit Score: 44.87  E-value: 1.60e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1972308123   8 ISAMLSIDNIDDNIYRSEGPHIGGIfgvNRLFGGYIAGQVYEAVRiykNKIKDENVIFSMHYNFVSAGDPRKLIDI 83
Cdd:COG1946     5 LLDLLDLERLEDGLFRGEISPDQGL---RRVFGGQVAAQALRAAR---RTVPEDRPPHSLHAYFLRPGDPDGPIEY 74
Thioesterase_II_repeat2 cd03445
Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases ...
 20-88 3.39e-05

Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP) domains, respectively. TEII has two tandem asymmetric hot dog folds that are structurally similar to one found in PaaI thioesterase, 4-hydroxybenzoyl-CoA thioesterase (4HBT) and beta-hydroxydecanoyl-ACP dehydratase and thus, the TEII monomer is equivalent to the homodimeric form of the latter three enzymes. Human TEII is expressed in T cells and has been shown to bind the product of the HIV-1 Nef gene.


Pssm-ID: 239529 [Multi-domain]  Cd Length: 94  Bit Score: 39.53  E-value: 3.39e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1972308123  20 NIYRSEGPHIGGIFGvNRLFGGYIAGQVYEAVRiykNKIKDENVIFSMHYNFVSAGDPRKLIDIKIEKV 88
Cdd:cd03445     1 DRFRGVSPPVPPGQG-RGVFGGQVLAQALVAAA---RTVPDDRVPHSLHSYFLRPGDPDQPIEYEVERL 65
PLN02868 PLN02868
acyl-CoA thioesterase family protein
 7-88 8.82e-04

acyl-CoA thioesterase family protein


Pssm-ID: 178459 [Multi-domain]  Cd Length: 413  Bit Score: 37.01  E-value: 8.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972308123   7 LISAMLSIDNIDDNIYRSEGPHIGGIFGvnRLFGGYIAGQVYEAVRIYKNKIKDenvIFSMHYNFVSAGDPRKLIDIKIE 86
Cdd:PLN02868  131 LVERILHLEPLEVDIFRGITLPDAPTFG--KVFGGQLVGQALAAASKTVDPLKL---VHSLHAYFLLVGDINLPIIYQVE 205


                  ..
gi 1972308123  87 KV 88
Cdd:PLN02868  206 RI 207
4HBT_3 pfam13622
Thioesterase-like superfamily; This family contains a wide variety of enzymes, principally ...
 39-111 8.27e-03

Thioesterase-like superfamily; This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.


Pssm-ID: 463937 [Multi-domain]  Cd Length: 246  Bit Score: 34.23  E-value: 8.27e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1972308123  39 FGGYIAGQVYEAVRiyknKIKDENVIFSMHYNFVSAGDPRKLIdikiekvgnvYTADVYHENKKIGLAHIKVR 111
Cdd:pfam13622  12 HGGYVAALLLRAAE----RTVPPDPLHSLHVDFLRPVPPGPVT----------IRVEVVRDGRSFSTRRVELS 70
 
Name Accession Description Interval E-value
TesB COG1946
Acyl-CoA thioesterase [Lipid transport and metabolism];
8-83 1.60e-06

Acyl-CoA thioesterase [Lipid transport and metabolism];


Pssm-ID: 441549 [Multi-domain]  Cd Length: 273  Bit Score: 44.87  E-value: 1.60e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1972308123   8 ISAMLSIDNIDDNIYRSEGPHIGGIfgvNRLFGGYIAGQVYEAVRiykNKIKDENVIFSMHYNFVSAGDPRKLIDI 83
Cdd:COG1946     5 LLDLLDLERLEDGLFRGEISPDQGL---RRVFGGQVAAQALRAAR---RTVPEDRPPHSLHAYFLRPGDPDGPIEY 74
Thioesterase_II_repeat2 cd03445
Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases ...
 20-88 3.39e-05

Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP) domains, respectively. TEII has two tandem asymmetric hot dog folds that are structurally similar to one found in PaaI thioesterase, 4-hydroxybenzoyl-CoA thioesterase (4HBT) and beta-hydroxydecanoyl-ACP dehydratase and thus, the TEII monomer is equivalent to the homodimeric form of the latter three enzymes. Human TEII is expressed in T cells and has been shown to bind the product of the HIV-1 Nef gene.


Pssm-ID: 239529 [Multi-domain]  Cd Length: 94  Bit Score: 39.53  E-value: 3.39e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1972308123  20 NIYRSEGPHIGGIFGvNRLFGGYIAGQVYEAVRiykNKIKDENVIFSMHYNFVSAGDPRKLIDIKIEKV 88
Cdd:cd03445     1 DRFRGVSPPVPPGQG-RGVFGGQVLAQALVAAA---RTVPDDRVPHSLHSYFLRPGDPDQPIEYEVERL 65
PLN02868 PLN02868
acyl-CoA thioesterase family protein
 7-88 8.82e-04

acyl-CoA thioesterase family protein


Pssm-ID: 178459 [Multi-domain]  Cd Length: 413  Bit Score: 37.01  E-value: 8.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972308123   7 LISAMLSIDNIDDNIYRSEGPHIGGIFGvnRLFGGYIAGQVYEAVRIYKNKIKDenvIFSMHYNFVSAGDPRKLIDIKIE 86
Cdd:PLN02868  131 LVERILHLEPLEVDIFRGITLPDAPTFG--KVFGGQLVGQALAAASKTVDPLKL---VHSLHAYFLLVGDINLPIIYQVE 205


                  ..
gi 1972308123  87 KV 88
Cdd:PLN02868  206 RI 207
4HBT_3 pfam13622
Thioesterase-like superfamily; This family contains a wide variety of enzymes, principally ...
 39-111 8.27e-03

Thioesterase-like superfamily; This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.


Pssm-ID: 463937 [Multi-domain]  Cd Length: 246  Bit Score: 34.23  E-value: 8.27e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1972308123  39 FGGYIAGQVYEAVRiyknKIKDENVIFSMHYNFVSAGDPRKLIdikiekvgnvYTADVYHENKKIGLAHIKVR 111
Cdd:pfam13622  12 HGGYVAALLLRAAE----RTVPPDPLHSLHVDFLRPVPPGPVT----------IRVEVVRDGRSFSTRRVELS 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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