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Conserved domains on  [gi|1972260651|ref|NP_001379711|]
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Protein pat-12 [Caenorhabditis elegans]

Protein Classification

EMC3/TMCO1 family protein( domain architecture ID 141324)

EMC3/TMCO1 family protein is a DUF106 domain-containing integral membrane protein; with similarity to Homo sapiens calcium load-activated calcium channel (TMCO1) and ER membrane protein complex subunit 3 (EMC3)

Gene Ontology:  GO:0016020
PubMed:  29281821

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EMC3_TMCO1 super family cl19818
Integral membrane protein EMC3/TMCO1-like; This entry represents a group of eukaryotic and ...
 388-438 8.17e-04

Integral membrane protein EMC3/TMCO1-like; This entry represents a group of eukaryotic and archaeal proteins. Eukaryotic members include EMC3, a subunit of the ER membrane protein complex (EMC) required for protein folding, and TMCO1, a ER calcium load-activated calcium channel. Archaeal members may function as insertases of the archaeal plasma membrane.


The actual alignment was detected with superfamily member COG1422:

Pssm-ID: 473210  Cd Length: 198  Bit Score: 41.81  E-value: 8.17e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1972260651  388 SSVLAKNFNDPERIDEYQ-RQKRL--EY---------EAIQRTNEKQAVSMAKQVNAMMQQQK 438
Cdd:COG1422     56 STLIQKYLMDWEKMGKYQeRMKAFqkERreaqergddEALKKLQEEQMEMMGDQMGMSKEQFK 118
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 891-1028 3.24e-03

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 3.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972260651  891 HRQSRSDSRGPPQMSRAASSIPLS--PQPTPQHHHHHHSQRPTTPGATRARNYIARATAPSPTPYSYDRARAYVPPALPP 968
Cdd:PHA03307   159 PAAVASDAASSRQAALPLSSPEETarAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSD 238

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1972260651  969 G--YRLADPIPDQRAMSPSPGHTRKLIRNVSESAQRLHPSGSTPQTSRAPS----RHSHRQSPNPR 1028
Cdd:PHA03307   239 SssSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSspreRSPSPSPSSPG 304
 
Name Accession Description Interval E-value
YidC COG1422
Archaeal YidC/Oxa1-related membrane protein, DUF106 family [Cell wall/membrane/envelope ...
 388-438 8.17e-04

Archaeal YidC/Oxa1-related membrane protein, DUF106 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441032  Cd Length: 198  Bit Score: 41.81  E-value: 8.17e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1972260651  388 SSVLAKNFNDPERIDEYQ-RQKRL--EY---------EAIQRTNEKQAVSMAKQVNAMMQQQK 438
Cdd:COG1422     56 STLIQKYLMDWEKMGKYQeRMKAFqkERreaqergddEALKKLQEEQMEMMGDQMGMSKEQFK 118
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 891-1028 3.24e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 3.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972260651  891 HRQSRSDSRGPPQMSRAASSIPLS--PQPTPQHHHHHHSQRPTTPGATRARNYIARATAPSPTPYSYDRARAYVPPALPP 968
Cdd:PHA03307   159 PAAVASDAASSRQAALPLSSPEETarAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSD 238

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1972260651  969 G--YRLADPIPDQRAMSPSPGHTRKLIRNVSESAQRLHPSGSTPQTSRAPS----RHSHRQSPNPR 1028
Cdd:PHA03307   239 SssSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSspreRSPSPSPSSPG 304
 
Name Accession Description Interval E-value
YidC COG1422
Archaeal YidC/Oxa1-related membrane protein, DUF106 family [Cell wall/membrane/envelope ...
 388-438 8.17e-04

Archaeal YidC/Oxa1-related membrane protein, DUF106 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441032  Cd Length: 198  Bit Score: 41.81  E-value: 8.17e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1972260651  388 SSVLAKNFNDPERIDEYQ-RQKRL--EY---------EAIQRTNEKQAVSMAKQVNAMMQQQK 438
Cdd:COG1422     56 STLIQKYLMDWEKMGKYQeRMKAFqkERreaqergddEALKKLQEEQMEMMGDQMGMSKEQFK 118
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 891-1028 3.24e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 3.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972260651  891 HRQSRSDSRGPPQMSRAASSIPLS--PQPTPQHHHHHHSQRPTTPGATRARNYIARATAPSPTPYSYDRARAYVPPALPP 968
Cdd:PHA03307   159 PAAVASDAASSRQAALPLSSPEETarAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSD 238

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1972260651  969 G--YRLADPIPDQRAMSPSPGHTRKLIRNVSESAQRLHPSGSTPQTSRAPS----RHSHRQSPNPR 1028
Cdd:PHA03307   239 SssSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSspreRSPSPSPSSPG 304
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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