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Conserved domains on  [gi|1972262984|ref|NP_001379779|]
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Smr domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SMR smart00463
Small MutS-related domain;
575-656 6.80e-16

Small MutS-related domain;


:

Pssm-ID: 214676 [Multi-domain]  Cd Length: 80  Bit Score: 72.72  E-value: 6.80e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972262984  575 PWFLDLHYMSVDGAVKLVKEAIEAVKYHlkaarNLDRRITVVTGSGNNSKCG-AKIKPQVLAMLQHNDYNY-ELVNDGCI 652
Cdd:smart00463   1 KWSLDLHGLTVEEALTALDKFLNNARLK-----GLEQKLVIITGKGKHSLGGkSGVKPALKEHLRVESFRFaEEGNSGVL 75


                   ....
gi 1972262984  653 RFKV 656
Cdd:smart00463  76 VVKL 79
AAA_33 super family cl38431
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 31-134 5.09e-08

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


The actual alignment was detected with superfamily member pfam13671:

Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 52.31  E-value: 5.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972262984  31 ILIRGVTGSGKSTLARELvnHSENGVIV--------------------KNDVSNNITRSVRKFIDE---DKHLIVVDEEN 87
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRL--LEELGAVRlssdderkrlfgegrpsisyYTDATDRTYERLHELARIalrAGRPVILDATN 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1972262984  88 VQRSSVKKFAELAVNGHYEIFVLEPDTDWRhdaiECKKRSEKDEEIG 134
Cdd:pfam13671  80 LRRDERARLLALAREYGVPVRIVVFEAPEE----VLRERLAARARAG 122
 
Name Accession Description Interval E-value
SMR smart00463
Small MutS-related domain;
575-656 6.80e-16

Small MutS-related domain;


Pssm-ID: 214676 [Multi-domain]  Cd Length: 80  Bit Score: 72.72  E-value: 6.80e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972262984  575 PWFLDLHYMSVDGAVKLVKEAIEAVKYHlkaarNLDRRITVVTGSGNNSKCG-AKIKPQVLAMLQHNDYNY-ELVNDGCI 652
Cdd:smart00463   1 KWSLDLHGLTVEEALTALDKFLNNARLK-----GLEQKLVIITGKGKHSLGGkSGVKPALKEHLRVESFRFaEEGNSGVL 75


                   ....
gi 1972262984  653 RFKV 656
Cdd:smart00463  76 VVKL 79
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 31-134 5.09e-08

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 52.31  E-value: 5.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972262984  31 ILIRGVTGSGKSTLARELvnHSENGVIV--------------------KNDVSNNITRSVRKFIDE---DKHLIVVDEEN 87
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRL--LEELGAVRlssdderkrlfgegrpsisyYTDATDRTYERLHELARIalrAGRPVILDATN 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1972262984  88 VQRSSVKKFAELAVNGHYEIFVLEPDTDWRhdaiECKKRSEKDEEIG 134
Cdd:pfam13671  80 LRRDERARLLALAREYGVPVRIVVFEAPEE----VLRERLAARARAG 122
COG4639 COG4639
Predicted kinase [General function prediction only];
27-151 2.95e-06

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 47.13  E-value: 2.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972262984  27 HRTIILIRGVTGSGKSTLARELVNHSEngVI--------VKNDVSNN---------ITRSVRKFIdEDKHLIVVDEENVQ 89
Cdd:COG4639     1 MLSLVVLIGLPGSGKSTFARRLFAPTE--VVssddiralLGGDENDQsawgdvfqlAHEIARARL-RAGRLTVVDATNLQ 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1972262984  90 RSSVKKFAELAVNGHYEIFVLEPDTDWRhdaiECKKRSEK-DEEIGS--IESKIMQLKENQLGWE 151
Cdd:COG4639    78 REARRRLLALARAYGALVVAVVLDVPLE----VCLARNAArDRQVPEevIRRMLRRLRRPPLPEE 138
pseT PHA02530
polynucleotide kinase; Provisional
 30-129 1.38e-04

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 44.24  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972262984  30 IILIRGVTGSGKSTLARELVNHSENGVIVKND------------------------VSNNITRSVRKFIDEDKHlIVVDE 85
Cdd:PHA02530    4 IILTVGVPGSGKSTWAREFAAKNPKAVNVNRDdlrqslfghgewgeykftkekedlVTKAQEAAALAALKSGKS-VIISD 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1972262984  86 ENVQRSSVKKFAELA--VNGHYEIFVLEPDTDwrhdaiECKKRSEK 129
Cdd:PHA02530   83 TNLNPERRRKWKELAkeLGAEFEEKVFDVPVE------ELVKRNRK 122
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 30-61 2.20e-03

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 39.62  E-value: 2.20e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1972262984  30 IILIRGVTGSGKSTLARELVNHSENGVIVKND 61
Cdd:cd02024     1 IVGISGVTNSGKTTLAKLLQRILPNCCVIHQD 32
 
Name Accession Description Interval E-value
SMR smart00463
Small MutS-related domain;
575-656 6.80e-16

Small MutS-related domain;


Pssm-ID: 214676 [Multi-domain]  Cd Length: 80  Bit Score: 72.72  E-value: 6.80e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972262984  575 PWFLDLHYMSVDGAVKLVKEAIEAVKYHlkaarNLDRRITVVTGSGNNSKCG-AKIKPQVLAMLQHNDYNY-ELVNDGCI 652
Cdd:smart00463   1 KWSLDLHGLTVEEALTALDKFLNNARLK-----GLEQKLVIITGKGKHSLGGkSGVKPALKEHLRVESFRFaEEGNSGVL 75


                   ....
gi 1972262984  653 RFKV 656
Cdd:smart00463  76 VVKL 79
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 31-134 5.09e-08

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 52.31  E-value: 5.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972262984  31 ILIRGVTGSGKSTLARELvnHSENGVIV--------------------KNDVSNNITRSVRKFIDE---DKHLIVVDEEN 87
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRL--LEELGAVRlssdderkrlfgegrpsisyYTDATDRTYERLHELARIalrAGRPVILDATN 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1972262984  88 VQRSSVKKFAELAVNGHYEIFVLEPDTDWRhdaiECKKRSEKDEEIG 134
Cdd:pfam13671  80 LRRDERARLLALAREYGVPVRIVVFEAPEE----VLRERLAARARAG 122
COG4639 COG4639
Predicted kinase [General function prediction only];
27-151 2.95e-06

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 47.13  E-value: 2.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972262984  27 HRTIILIRGVTGSGKSTLARELVNHSEngVI--------VKNDVSNN---------ITRSVRKFIdEDKHLIVVDEENVQ 89
Cdd:COG4639     1 MLSLVVLIGLPGSGKSTFARRLFAPTE--VVssddiralLGGDENDQsawgdvfqlAHEIARARL-RAGRLTVVDATNLQ 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1972262984  90 RSSVKKFAELAVNGHYEIFVLEPDTDWRhdaiECKKRSEK-DEEIGS--IESKIMQLKENQLGWE 151
Cdd:COG4639    78 REARRRLLALARAYGALVVAVVLDVPLE----VCLARNAArDRQVPEevIRRMLRRLRRPPLPEE 138
COG1373 COG1373
Predicted ATPase, AAA+ superfamily [General function prediction only];
26-105 1.34e-04

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440984 [Multi-domain]  Cd Length: 405  Bit Score: 44.93  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972262984  26 GHRTIILIRGVTGSGKSTLARELVNHSENGVIV---KNDVSNNITRSVRKFID------EDKHLIVVDEenVQR-----S 91
Cdd:COG1373    18 DNRKAVVITGPRQVGKTTLLKQLAKELENILYInldDPRLRALAEEDPDDLLEalkelyPGKTYLFLDE--IQRvpeweD 95

                          90
                  ....*....|....
gi 1972262984  92 SVKKFAELAVNGHY 105
Cdd:COG1373    96 ALKRLVDDGRNGRF 109
pseT PHA02530
polynucleotide kinase; Provisional
 30-129 1.38e-04

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 44.24  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972262984  30 IILIRGVTGSGKSTLARELVNHSENGVIVKND------------------------VSNNITRSVRKFIDEDKHlIVVDE 85
Cdd:PHA02530    4 IILTVGVPGSGKSTWAREFAAKNPKAVNVNRDdlrqslfghgewgeykftkekedlVTKAQEAAALAALKSGKS-VIISD 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1972262984  86 ENVQRSSVKKFAELA--VNGHYEIFVLEPDTDwrhdaiECKKRSEK 129
Cdd:PHA02530   83 TNLNPERRRKWKELAkeLGAEFEEKVFDVPVE------ELVKRNRK 122
AAA_18 pfam13238
AAA domain;
31-142 4.63e-04

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 40.49  E-value: 4.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972262984  31 ILIRGVTGSGKSTLARELVNHSENGVIVKNDVSNNITR-------SVRKFIDEDKHLIVVD--EENVQRSSVKKfaeLAV 101
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGFGDNVRDLALENGLVlgddpetRESKRLDEDKLDRLLDllEENAALEEGGN---LII 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1972262984 102 NGHYEIFVLEPDTDWRHDAIEC---------KKRSEKDEEI-GSIESKIMQ 142
Cdd:pfam13238  78 DGHLAELEPERAKDLVGIVLRAspeellerlEKRGYEEAKIkENEEAEILG 128
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 26-58 4.68e-04

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 41.75  E-value: 4.68e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1972262984  26 GHRTIILIRGVTGSGKSTLARELVNH-SENGVIV 58
Cdd:COG0572     5 GKPRIIGIAGPSGSGKTTFARRLAEQlGADKVVV 38
NRK1 cd02024
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide ...
 30-61 2.20e-03

Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.


Pssm-ID: 238982 [Multi-domain]  Cd Length: 187  Bit Score: 39.62  E-value: 2.20e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1972262984  30 IILIRGVTGSGKSTLARELVNHSENGVIVKND 61
Cdd:cd02024     1 IVGISGVTNSGKTTLAKLLQRILPNCCVIHQD 32
Viral_helicase1 pfam01443
Viral (Superfamily 1) RNA helicase; Helicase activity for this family has been demonstrated ...
 31-85 4.25e-03

Viral (Superfamily 1) RNA helicase; Helicase activity for this family has been demonstrated and NTPase activity. This helicase has multiple roles at different stages of viral RNA replication, as dissected by mutational analysis.


Pssm-ID: 366646 [Multi-domain]  Cd Length: 227  Bit Score: 39.28  E-value: 4.25e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1972262984  31 ILIRGVTGSGKSTLARELVNHSENGVIV-------KNDVSNNITRSVRKF----IDEDKHLIVVDE 85
Cdd:pfam01443   1 IVVHGVPGCGKSTLIRKLLRTSRVIRPTaelrtegKPDLPNLNVRTVDTFlmalLKPTGKILILDE 66
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
30-51 4.45e-03

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 38.36  E-value: 4.45e-03
                          10        20
                  ....*....|....*....|..
gi 1972262984  30 IILIRGVTGSGKSTLARELVNH 51
Cdd:COG0645     1 LILVCGLPGSGKSTLARALAER 22
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 13-58 4.93e-03

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 38.25  E-value: 4.93e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1972262984  13 DAEISDIQKCL---VEGHRTIILIRGVTGSGKSTLARELVNH-SENGVIV 58
Cdd:pfam13191   6 EEELEQLLDALdrvRSGRPPSVLLTGEAGTGKTTLLRELLRAlERDGGYF 55
PRK06762 PRK06762
hypothetical protein; Provisional
 29-62 5.92e-03

hypothetical protein; Provisional


Pssm-ID: 235858  Cd Length: 166  Bit Score: 38.03  E-value: 5.92e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1972262984  29 TIILIRGVTGSGKSTLARELVNHSENGV-IVKNDV 62
Cdd:PRK06762    3 TLIIIRGNSGSGKTTIAKQLQERLGRGTlLVSQDV 37
AAA_14 pfam13173
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 27-105 8.95e-03

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 463799 [Multi-domain]  Cd Length: 128  Bit Score: 36.80  E-value: 8.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972262984  27 HRTIILIRGVTGSGKSTLARELV-NHSENGVIV---------KNDVSNNITRSVRKFIDEDKHLIVVDEenVQR-----S 91
Cdd:pfam13173   1 SRKILVITGPRQVGKTTLLLQLIkELLPPENILyinlddprlLKLADFELLELFLELLYPGKTYLFLDE--IQRvpdweL 78

                          90
                  ....*....|....
gi 1972262984  92 SVKKFAELAVNGHY 105
Cdd:pfam13173  79 ALKRLYDDGPNGRV 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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