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Conserved domains on  [gi|1972263576|ref|NP_001379844|]
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CRIB domain-containing protein [Caenorhabditis elegans]

Protein Classification

Wiskott-Aldrich syndrome protein; serine/threonine-protein kinase PAK 3( domain architecture ID 10645184)

Wiskott-Aldrich syndrome protein (WASp) acts as an effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex| serine/threonine-protein kinase PAK 3 (p21-activated kinase 3) catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates; PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PBD smart00285
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 22-56 1.94e-05

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


:

Pssm-ID: 197628  Cd Length: 36  Bit Score: 41.81  E-value: 1.94e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1972263576   22 ISLPSDFRHLAHVGPMG-SSEIENLRTSDNVIDTVN 56
Cdd:smart00285   1 ISTPTNFKHIAHVGFDGqTGGFTGLPTEWKSLLKTS 36
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
298-390 6.84e-04

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14965:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 576  Bit Score: 42.42  E-value: 6.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972263576 298 SGYPTLALEKDRAFMKHL------------VEKYELGVAPETIRLRKKkgPAPKAPSLPPDLSSPTFQAPGFIPAFSARP 365
Cdd:PRK14965  344 ASFPRLVLEMALLKMATLapgapvselldrLEALERGAPAPPSAAWGA--PTPAAPAAPPPAAAPPVPPAAPARPAAARP 421

                          90       100
                  ....*....|....*....|....*
gi 1972263576 366 VSMPPNRPPPSYEAPSFDAPEAPGT 390
Cdd:PRK14965  422 APAPAPPAAAAPPARSADPAAAASA 446
 
Name Accession Description Interval E-value
PBD smart00285
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 22-56 1.94e-05

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 197628  Cd Length: 36  Bit Score: 41.81  E-value: 1.94e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1972263576   22 ISLPSDFRHLAHVGPMG-SSEIENLRTSDNVIDTVN 56
Cdd:smart00285   1 ISTPTNFKHIAHVGFDGqTGGFTGLPTEWKSLLKTS 36
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 298-390 6.84e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 42.42  E-value: 6.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972263576 298 SGYPTLALEKDRAFMKHL------------VEKYELGVAPETIRLRKKkgPAPKAPSLPPDLSSPTFQAPGFIPAFSARP 365
Cdd:PRK14965  344 ASFPRLVLEMALLKMATLapgapvselldrLEALERGAPAPPSAAWGA--PTPAAPAAPPPAAAPPVPPAAPARPAAARP 421

                          90       100
                  ....*....|....*....|....*
gi 1972263576 366 VSMPPNRPPPSYEAPSFDAPEAPGT 390
Cdd:PRK14965  422 APAPAPPAAAAPPARSADPAAAASA 446
CRIB cd00132
PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; ...
 21-36 1.14e-03

PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the Ras-Rac pathway. CRIB-containing effector proteins are functionally diverse and include serine/threonine kinases, tyrosine kinases, actin-binding proteins, and adapter molecules.


Pssm-ID: 238077  Cd Length: 42  Bit Score: 37.03  E-value: 1.14e-03
                          10
                  ....*....|....*.
gi 1972263576  21 MISLPSDFRHLAHVGP 36
Cdd:cd00132     2 EISTPTDFKHISHVGW 17
 
Name Accession Description Interval E-value
PBD smart00285
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 22-56 1.94e-05

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 197628  Cd Length: 36  Bit Score: 41.81  E-value: 1.94e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1972263576   22 ISLPSDFRHLAHVGPMG-SSEIENLRTSDNVIDTVN 56
Cdd:smart00285   1 ISTPTNFKHIAHVGFDGqTGGFTGLPTEWKSLLKTS 36
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 298-390 6.84e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 42.42  E-value: 6.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1972263576 298 SGYPTLALEKDRAFMKHL------------VEKYELGVAPETIRLRKKkgPAPKAPSLPPDLSSPTFQAPGFIPAFSARP 365
Cdd:PRK14965  344 ASFPRLVLEMALLKMATLapgapvselldrLEALERGAPAPPSAAWGA--PTPAAPAAPPPAAAPPVPPAAPARPAAARP 421

                          90       100
                  ....*....|....*....|....*
gi 1972263576 366 VSMPPNRPPPSYEAPSFDAPEAPGT 390
Cdd:PRK14965  422 APAPAPPAAAAPPARSADPAAAASA 446
CRIB cd00132
PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; ...
 21-36 1.14e-03

PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the Ras-Rac pathway. CRIB-containing effector proteins are functionally diverse and include serine/threonine kinases, tyrosine kinases, actin-binding proteins, and adapter molecules.


Pssm-ID: 238077  Cd Length: 42  Bit Score: 37.03  E-value: 1.14e-03
                          10
                  ....*....|....*.
gi 1972263576  21 MISLPSDFRHLAHVGP 36
Cdd:cd00132     2 EISTPTDFKHISHVGW 17
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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