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Conserved domains on  [gi|1983575717|ref|NP_001380394|]
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ankyrin repeat and MYND domain-containing protein 1 isoform 13 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
285-453 4.15e-16

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.61  E-value: 4.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 285 RMALSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAalp 363
Cdd:COG0666    88 NTLLHAAARNGDLEIVKLLLEAGADVNARDKDgETPLHLAAYNGNLEIVKLLLEAGADVNAQDN---DGNTPLHLAA--- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 364 gEEG-VQIVELLLHAITDVDAK----------ASDEDDTykpgKVVKELLTQGADPNLPLTKGlGSALCVACdltyehqr 432
Cdd:COG0666   162 -ANGnLEIVKLLLEAGADVNARdndgetplhlAAENGHL----EIVKLLLEAGADVNAKDNDG-KTALDLAA-------- 227

                         170       180
                  ....*....|....*....|.
gi 1983575717 433 nMDSKLALIDRLISHGADILK 453
Cdd:COG0666   228 -ENGNLEIVKLLLEAGADLNA 247
COG4642 super family cl34799
Uncharacterized conserved protein [Function unknown];
2-67 8.87e-15

Uncharacterized conserved protein [Function unknown];


The actual alignment was detected with superfamily member COG4642:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 74.99  E-value: 8.87e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1983575717   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMKT 67
Cdd:COG4642   196 YEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYAD 261
zf-MYND pfam01753
MYND finger;
567-607 9.11e-09

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 51.65  E-value: 9.11e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1983575717 567 CYQCGRSiGVRLLPCPRCYGILTCSKYCKTKAWtEFHKKDC 607
Cdd:pfam01753   1 CAVCGKE-ALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
73-100 1.66e-03

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.09  E-value: 1.66e-03
                          10        20
                  ....*....|....*....|....*...
gi 1983575717  73 HCHNDIVNLLLDCGADVNKCSDEGLTAL 100
Cdd:COG0666   130 NGNLEIVKLLLEAGADVNAQDNDGNTPL 157
DUF2857 super family cl12747
Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.
 247-321 7.44e-03

Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.


The actual alignment was detected with superfamily member pfam11198:

Pssm-ID: 431719  Cd Length: 174  Bit Score: 38.02  E-value: 7.44e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1983575717 247 FSIELSQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLccvpMQVLF 321
Cdd:pfam11198  25 FSPEELDALKSLSLEDLHYLSNARVSFLRVTVDHDVLRRLLAQAREEQERRQLIDRALRLGASIEL----MARLF 95
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
285-453 4.15e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.61  E-value: 4.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 285 RMALSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAalp 363
Cdd:COG0666    88 NTLLHAAARNGDLEIVKLLLEAGADVNARDKDgETPLHLAAYNGNLEIVKLLLEAGADVNAQDN---DGNTPLHLAA--- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 364 gEEG-VQIVELLLHAITDVDAK----------ASDEDDTykpgKVVKELLTQGADPNLPLTKGlGSALCVACdltyehqr 432
Cdd:COG0666   162 -ANGnLEIVKLLLEAGADVNARdndgetplhlAAENGHL----EIVKLLLEAGADVNAKDNDG-KTALDLAA-------- 227

                         170       180
                  ....*....|....*....|.
gi 1983575717 433 nMDSKLALIDRLISHGADILK 453
Cdd:COG0666   228 -ENGNLEIVKLLLEAGADLNA 247
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-67 8.87e-15

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 74.99  E-value: 8.87e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1983575717   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMKT 67
Cdd:COG4642   196 YEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYAD 261
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 1-61 5.92e-11

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 66.01  E-value: 5.92e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1983575717   1 MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG 61
Cdd:PLN03185   33 MYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLG 93
Ank_2 pfam12796
Ankyrin repeats (3 copies);
299-384 2.09e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.12  E-value: 2.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 299 TIKLLLRRGADPNLC-CVPMQVLFLAVKAGDVDGVRLLLEHGARTDicfppQLSTLTPLHIAAalpgEEG-VQIVELLLH 376
Cdd:pfam12796  12 LVKLLLENGADANLQdKNGRTALHLAAKNGHLEIVKLLLEHADVNL-----KDNGRTALHYAA----RSGhLEIVKLLLE 82


                  ....*...
gi 1983575717 377 AITDVDAK 384
Cdd:pfam12796  83 KGADINVK 90
zf-MYND pfam01753
MYND finger;
567-607 9.11e-09

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 51.65  E-value: 9.11e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1983575717 567 CYQCGRSiGVRLLPCPRCYGILTCSKYCKTKAWtEFHKKDC 607
Cdd:pfam01753   1 CAVCGKE-ALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 287-424 6.66e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.57  E-value: 6.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 287 ALSMIERRKRWRTIKLLLRRGADPNlccVPMQV----LFLAVKAGDVDGVRLLLEHGARTDIcfpPQLSTLTPLHIAAAL 362
Cdd:PHA02878  171 ALHYATENKDQRLTELLLSYGANVN---IPDKTnnspLHHAVKHYNKPIVHILLENGASTDA---RDKCGNTPLHISVGY 244

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1983575717 363 PgeEGVQIVELLLHAITDVDAKASDEDDT-----YKPGKVVKELLTQGADPNL-------PLTKGLGSALCVAC 424
Cdd:PHA02878  245 C--KDYDILKLLLEHGVDVNAKSYILGLTalhssIKSERKLKLLLEYGADINSlnsykltPLSSAVKQYLCINI 316
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 25-47 2.65e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 38.54  E-value: 2.65e-04
                          10        20
                  ....*....|....*....|...
gi 1983575717  25 YHGQFYRDHCHGLGTYMWPDGSS 47
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
24-44 5.75e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 37.71  E-value: 5.75e-04
                           10        20
                   ....*....|....*....|.
gi 1983575717   24 SYHGQFYRDHCHGLGTYMWPD 44
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
73-100 1.66e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.09  E-value: 1.66e-03
                          10        20
                  ....*....|....*....|....*...
gi 1983575717  73 HCHNDIVNLLLDCGADVNKCSDEGLTAL 100
Cdd:COG0666   130 NGNLEIVKLLLEAGADVNAQDNDGNTPL 157
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 77-109 2.88e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.80  E-value: 2.88e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1983575717  77 DIVNLLLDCGADVNKCSDEGLTALSMCFLLHYP 109
Cdd:PHA03100  206 EFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
DUF2857 pfam11198
Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.
 247-321 7.44e-03

Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.


Pssm-ID: 431719  Cd Length: 174  Bit Score: 38.02  E-value: 7.44e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1983575717 247 FSIELSQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLccvpMQVLF 321
Cdd:pfam11198  25 FSPEELDALKSLSLEDLHYLSNARVSFLRVTVDHDVLRRLLAQAREEQERRQLIDRALRLGASIEL----MARLF 95
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
285-453 4.15e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 79.61  E-value: 4.15e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 285 RMALSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAalp 363
Cdd:COG0666    88 NTLLHAAARNGDLEIVKLLLEAGADVNARDKDgETPLHLAAYNGNLEIVKLLLEAGADVNAQDN---DGNTPLHLAA--- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 364 gEEG-VQIVELLLHAITDVDAK----------ASDEDDTykpgKVVKELLTQGADPNLPLTKGlGSALCVACdltyehqr 432
Cdd:COG0666   162 -ANGnLEIVKLLLEAGADVNARdndgetplhlAAENGHL----EIVKLLLEAGADVNAKDNDG-KTALDLAA-------- 227

                         170       180
                  ....*....|....*....|.
gi 1983575717 433 nMDSKLALIDRLISHGADILK 453
Cdd:COG0666   228 -ENGNLEIVKLLLEAGADLNA 247
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-67 8.87e-15

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 74.99  E-value: 8.87e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1983575717   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMKT 67
Cdd:COG4642   196 YEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYAD 261
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
287-452 2.32e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 74.22  E-value: 2.32e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 287 ALSMIERRKRWRTIKLLLRRGADPNLCCVPMQ-VLFLAVKAGDVDGVRLLLEHGARTDIcfpPQLSTLTPLHIAAalpgE 365
Cdd:COG0666   123 PLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNtPLHLAAANGNLEIVKLLLEAGADVNA---RDNDGETPLHLAA----E 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 366 EG-VQIVELLLHAITDVDAKASDEDDT------YKPGKVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKL 438
Cdd:COG0666   196 NGhLEIVKLLLEAGADVNAKDNDGKTAldlaaeNGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275

                         170
                  ....*....|....
gi 1983575717 439 ALIDRLISHGADIL 452
Cdd:COG0666   276 LLLAAALLDLLTLL 289
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-66 2.56e-13

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 70.76  E-value: 2.56e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1983575717   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMK 66
Cdd:COG4642   150 YEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYA 214
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-64 6.08e-13

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 69.60  E-value: 6.08e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1983575717   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMY 64
Cdd:COG4642   173 YEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLT 235
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 1-61 5.92e-11

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 66.01  E-value: 5.92e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1983575717   1 MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG 61
Cdd:PLN03185   33 MYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLG 93
Ank_2 pfam12796
Ankyrin repeats (3 copies);
299-384 2.09e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.12  E-value: 2.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 299 TIKLLLRRGADPNLC-CVPMQVLFLAVKAGDVDGVRLLLEHGARTDicfppQLSTLTPLHIAAalpgEEG-VQIVELLLH 376
Cdd:pfam12796  12 LVKLLLENGADANLQdKNGRTALHLAAKNGHLEIVKLLLEHADVNL-----KDNGRTALHYAA----RSGhLEIVKLLLE 82


                  ....*...
gi 1983575717 377 AITDVDAK 384
Cdd:pfam12796  83 KGADINVK 90
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
1-64 3.30e-09

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 58.43  E-value: 3.30e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1983575717   1 MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMY 64
Cdd:COG4642   126 GYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLT 189
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-52 5.12e-09

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 58.04  E-value: 5.12e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1983575717   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTF 52
Cdd:COG4642   219 YEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYADGSVYEGEW 269
zf-MYND pfam01753
MYND finger;
567-607 9.11e-09

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 51.65  E-value: 9.11e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1983575717 567 CYQCGRSiGVRLLPCPRCYGILTCSKYCKTKAWtEFHKKDC 607
Cdd:pfam01753   1 CAVCGKE-ALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
Ank_2 pfam12796
Ankyrin repeats (3 copies);
320-410 1.35e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.81  E-value: 1.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 320 LFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAAlpgEEGVQIVELLLhaiTDVDAKASDEDDT-------Y 392
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDK---NGRTALHLAAK---NGHLEIVKLLL---EHADVNLKDNGRTalhyaarS 71

                          90
                  ....*....|....*...
gi 1983575717 393 KPGKVVKELLTQGADPNL 410
Cdd:pfam12796  72 GHLEIVKLLLEKGADINV 89
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 287-424 6.66e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.57  E-value: 6.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 287 ALSMIERRKRWRTIKLLLRRGADPNlccVPMQV----LFLAVKAGDVDGVRLLLEHGARTDIcfpPQLSTLTPLHIAAAL 362
Cdd:PHA02878  171 ALHYATENKDQRLTELLLSYGANVN---IPDKTnnspLHHAVKHYNKPIVHILLENGASTDA---RDKCGNTPLHISVGY 244

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1983575717 363 PgeEGVQIVELLLHAITDVDAKASDEDDT-----YKPGKVVKELLTQGADPNL-------PLTKGLGSALCVAC 424
Cdd:PHA02878  245 C--KDYDILKLLLEHGVDVNAKSYILGLTalhssIKSERKLKLLLEYGADINSlnsykltPLSSAVKQYLCINI 316
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 2-72 9.51e-07

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 52.14  E-value: 9.51e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1983575717   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMK-TRLFQT 72
Cdd:PLN03185  126 YLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGKGVFYPAgSRVPAV 197
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 288-450 1.36e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.15  E-value: 1.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 288 LSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDI--CFppqlsTLTPLHIAAAlpg 364
Cdd:PHA02875  106 LHLATILKKLDIMKLLIARGADPDIPNTDkFSPLHLAVMMGDIKGIELLIDHKACLDIedCC-----GCTPLIIAMA--- 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 365 eegvqivelllhaitdvdakasdeddtYKPGKVVKELLTQGADPNLPLTKGLGSALCVACDltyehqrnmDSKLALIDRL 444
Cdd:PHA02875  178 ---------------------------KGDIAICKMLLDSGANIDYFGKNGCVAALCYAIE---------NNKIDIVRLF 221


                  ....*.
gi 1983575717 445 ISHGAD 450
Cdd:PHA02875  222 IKRGAD 227
PHA03095 PHA03095
ankyrin-like protein; Provisional
 300-451 1.53e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.10  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 300 IKLLLRRGADPN----LCCVPMQVLFLAVKAGDVDGVRLLLEHGARTDIcfpPQLSTLTPLHIAAALPGEEGVqiVELLL 375
Cdd:PHA03095   30 VRRLLAAGADVNfrgeYGKTPLHLYLHYSSEKVKDIVRLLLEAGADVNA---PERCGFTPLHLYLYNATTLDV--IKLLI 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 376 HAITDVDAKaSDEDDT----YKPG-----KVVKELLTQGADPNlpltkglgsalcvACDLtYEHQ------RNMDSKLAL 440
Cdd:PHA03095  105 KAGADVNAK-DKVGRTplhvYLSGfninpKVIRLLLRKGADVN-------------ALDL-YGMTplavllKSRNANVEL 169

                         170
                  ....*....|.
gi 1983575717 441 IDRLISHGADI 451
Cdd:PHA03095  170 LRLLIDAGADV 180
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 298-410 1.67e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 47.74  E-value: 1.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 298 RTIKLLLRRGADPNLC----CVPMQVLfLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAALPGEEgVQIVEL 373
Cdd:PHA03100   87 EIVKLLLEYGANVNAPdnngITPLLYA-ISKKSNSYSIVEYLLDNGANVNIKNS---DGENLLHLYLESNKID-LKILKL 161

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1983575717 374 LLHAITDVDAKAS-----------DEDD----------TYKPGK-VVKELLTQGADPNL 410
Cdd:PHA03100  162 LIDKGVDINAKNRvnyllsygvpiNIKDvygftplhyaVYNNNPeFVKYLLDLGANPNL 220
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 2-67 1.91e-05

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 48.29  E-value: 1.91e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1983575717   2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTmYMKT 67
Cdd:PLN03185   11 YSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGT-YTGT 75
PHA03095 PHA03095
ankyrin-like protein; Provisional
 296-451 1.95e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 47.71  E-value: 1.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 296 RWRTIKLLLRRGADPNLCCV----PMQVlFLAVKAGDVDGVRLLLEHGArtDICfPPQLSTLTPLHIAAALPGEEgVQIV 371
Cdd:PHA03095   96 TLDVIKLLIKAGADVNAKDKvgrtPLHV-YLSGFNINPKVIRLLLRKGA--DVN-ALDLYGMTPLAVLLKSRNAN-VELL 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 372 ELLLHAITDVDAKaSDEDDT--------YKP-GKVVKELLTQGADPNLPLTKGlgsalcvacdLTYEHQRNMDS--KLAL 440
Cdd:PHA03095  171 RLLIDAGADVYAV-DDRFRSllhhhlqsFKPrARIVRELIRAGCDPAATDMLG----------NTPLHSMATGSscKRSL 239

                         170
                  ....*....|.
gi 1983575717 441 IDRLISHGADI 451
Cdd:PHA03095  240 VLPLLIAGISI 250
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
13-66 4.31e-05

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 46.10  E-value: 4.31e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1983575717  13 GYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMK 66
Cdd:COG4642   115 GGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYA 168
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 283-451 2.16e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.27  E-value: 2.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 283 MRRMALSMIERRKRWRTIKLLLRRGADPN------LCCVPMQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQlstLTPL 356
Cdd:PHA03100   34 KPVLPLYLAKEARNIDVVKILLDNGADINsstknnSTPLHYLSNIKYNLTDVKEIVKLLLEYGANVNAPDNNG---ITPL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 357 HIAAALPGEEgVQIVELLLHAITDVDAKASD------------EDDTykpgKVVKELLTQGADPNlpltkglgsalcvac 424
Cdd:PHA03100  111 LYAISKKSNS-YSIVEYLLDNGANVNIKNSDgenllhlylesnKIDL----KILKLLIDKGVDIN--------------- 170

                         170       180
                  ....*....|....*....|....*..
gi 1983575717 425 dltyehqrNMDSklalIDRLISHGADI 451
Cdd:PHA03100  171 --------AKNR----VNYLLSYGVPI 185
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 25-47 2.65e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 38.54  E-value: 2.65e-04
                          10        20
                  ....*....|....*....|...
gi 1983575717  25 YHGQFYRDHCHGLGTYMWPDGSS 47
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
24-44 5.75e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 37.71  E-value: 5.75e-04
                           10        20
                   ....*....|....*....|.
gi 1983575717   24 SYHGQFYRDHCHGLGTYMWPD 44
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
73-100 1.66e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.09  E-value: 1.66e-03
                          10        20
                  ....*....|....*....|....*...
gi 1983575717  73 HCHNDIVNLLLDCGADVNKCSDEGLTAL 100
Cdd:COG0666   130 NGNLEIVKLLLEAGADVNAQDNDGNTPL 157
Ank_4 pfam13637
Ankyrin repeats (many copies);
317-375 1.97e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 1.97e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1983575717 317 MQVLFLAVKAGDVDGVRLLLEHGA---RTDICFppqlstLTPLHIAAAlpgEEGVQIVELLL 375
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGAdinAVDGNG------ETALHFAAS---NGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 303-413 2.65e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 40.74  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1983575717 303 LLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDICFPpqlSTLTPLHIAAalpgEEG-VQIVELLLHAITD 380
Cdd:PHA02875   21 LLDIGINPNFEIYDgISPIKLAMKFRDSEAIKLLMKHGAIPDVKYP---DIESELHDAV----EEGdVKAVEELLDLGKF 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1983575717 381 VDakasdeDDTYKPG-------------KVVKELLTQGADPNLPLT 413
Cdd:PHA02875   94 AD------DVFYKDGmtplhlatilkklDIMKLLIARGADPDIPNT 133
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 77-109 2.88e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.80  E-value: 2.88e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1983575717  77 DIVNLLLDCGADVNKCSDEGLTALSMCFLLHYP 109
Cdd:PHA03100  206 EFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
73-100 6.62e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 39.17  E-value: 6.62e-03
                          10        20
                  ....*....|....*....|....*...
gi 1983575717  73 HCHNDIVNLLLDCGADVNKCSDEGLTAL 100
Cdd:COG0666   163 NGNLEIVKLLLEAGADVNARDNDGETPL 190
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 354-384 7.15e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.57  E-value: 7.15e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1983575717 354 TPLHIAAALPGeeGVQIVELLLHAITDVDAK 384
Cdd:pfam00023   4 TPLHLAAGRRG--NLEIVKLLLSKGADVNAR 32
DUF2857 pfam11198
Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.
 247-321 7.44e-03

Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.


Pssm-ID: 431719  Cd Length: 174  Bit Score: 38.02  E-value: 7.44e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1983575717 247 FSIELSQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLccvpMQVLF 321
Cdd:pfam11198  25 FSPEELDALKSLSLEDLHYLSNARVSFLRVTVDHDVLRRLLAQAREEQERRQLIDRALRLGASIEL----MARLF 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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