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Conserved domains on  [gi|1996240433|ref|NP_001380617|]
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NIF3-like protein 1 isoform 1 [Rattus norvegicus]

Protein Classification

Nif3-like dinuclear metal center hexameric protein( domain architecture ID 10484881)

Nif3-like dinuclear metal center hexameric protein may be a prohibitive factor restricting the infestation of certain pathogens

CATH:  3.40.1390.30
Gene Ontology:  GO:0046872

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
NIF3 pfam01784
NIF3 (NGG1p interacting factor 3); This family contains several NIF3 (NGG1p interacting factor ...
32-353 2.01e-80

NIF3 (NGG1p interacting factor 3); This family contains several NIF3 (NGG1p interacting factor 3) protein homologs. NIF3 interacts with the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of this interaction is unknown.


:

Pssm-ID: 426431  Cd Length: 236  Bit Score: 245.99  E-value: 2.01e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433  32 LLSSLNDFASLSFAESWDNVGLLVEpSPPHTVNTLFLTNDLTEEVMEEALQKKADLILSYHPPIFRPMKHITWKTWKERL 111
Cdd:pfam01784   2 IIELLEEIAPPELAEDWDNVGLQVG-DPENEVTKILVALDATEEVIEEAIENGADLIITHHPLIFRPLKSLTGDDPKGRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 112 VIRALENRVAIYSPHTAYDAAPQGVNSWLAKGLGTCTTRPIHPSKApnyptegthrlefsanhsqdldkvmsavkgvggv 191
Cdd:pfam01784  81 IKKLIKNNISLYSAHTNLDAAPGGVNDWLAELLGLESIEPLEPTEE---------------------------------- 126
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 192 svtsfparcdgeeqtrvslnctqkalmqvlaflsqdrqlyqkteilslekplllHTGMGRLCTLDESVSLATMIERIKRH 271
Cdd:pfam01784 127 ------------------------------------------------------GEGLGRIGELPEPMSLEELAAKVKEK 152
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 272 LKLPHLRLALGvgrtLESPVKVVALCAGSGGSVL---QGVEADLYLTGEMSHHDVLDAASKGINVILCEHSNTERGFLSD 348
Cdd:pfam01784 153 LGLEGVRVVGD----LDKPIKKVAICGGSGSSLIdeaKAKGADVLITGDVKYHDALDAQEKGINLIDAGHYATERFGLEA 228

                  ....*
gi 1996240433 349 LQEML 353
Cdd:pfam01784 229 LAELL 233
 
Name Accession Description Interval E-value
NIF3 pfam01784
NIF3 (NGG1p interacting factor 3); This family contains several NIF3 (NGG1p interacting factor ...
32-353 2.01e-80

NIF3 (NGG1p interacting factor 3); This family contains several NIF3 (NGG1p interacting factor 3) protein homologs. NIF3 interacts with the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of this interaction is unknown.


Pssm-ID: 426431  Cd Length: 236  Bit Score: 245.99  E-value: 2.01e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433  32 LLSSLNDFASLSFAESWDNVGLLVEpSPPHTVNTLFLTNDLTEEVMEEALQKKADLILSYHPPIFRPMKHITWKTWKERL 111
Cdd:pfam01784   2 IIELLEEIAPPELAEDWDNVGLQVG-DPENEVTKILVALDATEEVIEEAIENGADLIITHHPLIFRPLKSLTGDDPKGRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 112 VIRALENRVAIYSPHTAYDAAPQGVNSWLAKGLGTCTTRPIHPSKApnyptegthrlefsanhsqdldkvmsavkgvggv 191
Cdd:pfam01784  81 IKKLIKNNISLYSAHTNLDAAPGGVNDWLAELLGLESIEPLEPTEE---------------------------------- 126
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 192 svtsfparcdgeeqtrvslnctqkalmqvlaflsqdrqlyqkteilslekplllHTGMGRLCTLDESVSLATMIERIKRH 271
Cdd:pfam01784 127 ------------------------------------------------------GEGLGRIGELPEPMSLEELAAKVKEK 152
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 272 LKLPHLRLALGvgrtLESPVKVVALCAGSGGSVL---QGVEADLYLTGEMSHHDVLDAASKGINVILCEHSNTERGFLSD 348
Cdd:pfam01784 153 LGLEGVRVVGD----LDKPIKKVAICGGSGSSLIdeaKAKGADVLITGDVKYHDALDAQEKGINLIDAGHYATERFGLEA 228

                  ....*
gi 1996240433 349 LQEML 353
Cdd:pfam01784 229 LAELL 233
NIF3 COG0327
Putative GTP cyclohydrolase 1 type 2, NIF3 family [Coenzyme transport and metabolism]; ...
27-372 1.63e-56

Putative GTP cyclohydrolase 1 type 2, NIF3 family [Coenzyme transport and metabolism]; Putative GTP cyclohydrolase 1 type 2, NIF3 family is part of the Pathway/BioSystem: Folate biosynthesis


Pssm-ID: 440096  Cd Length: 254  Bit Score: 185.35  E-value: 1.63e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433  27 MDLKALLSSLNDFASLSFAESWDNVGLLV-EPSPPhtVNTLFLTNDLTEEVMEEALQKKADLILSYHPPIFRPMKHITWK 105
Cdd:COG0327     1 MTLSELVAALEELLPPALAESWDPNGLQVgEGRAE--VTRIVTAVDATQAVIEEAIEAGADLLIVHHPLFWKGEDSITAG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 106 TWKERLVIRALENRVAIYSPHTAYDAAPQ-GVNSWLAKGLGTCTTRPIHPSKApnyptegthrlefsanhsqdldkvmsa 184
Cdd:COG0327    79 TVKGRRLALLIKNDIALYAAHTPLDAHPElGNNAQLARLLGLEDVEPLGPSGG--------------------------- 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 185 vkgvggvsvtsfparcdgeeqtrvslnctqkalmqvlaflsqdrqlyqkteilslekplllhTGMGRLCTLDESVSLATM 264
Cdd:COG0327   132 --------------------------------------------------------------EGLGRIGELPEPMTLEEL 149
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 265 IERIKRHLKLPHLRLalgVGRtLESPVKVVALCAGSGGSVLQGVE---ADLYLTGEMSHHDVLDAASKGINVILCEHSNT 341
Cdd:COG0327   150 AARVKEALGLRGVRV---VGD-PDRPIRRVAICTGSGQSLIEEAAaagADAYITGEIKEHTAHDAREQGIALIDAGHYAT 225
                         330       340       350
                  ....*....|....*....|....*....|.
gi 1996240433 342 ERGFLSDLQEMLGVHLEnkINIILSETDRDP 372
Cdd:COG0327   226 ERPGVQALAEWLAEAFG--LEVEFIDIDNPP 254
YbgI_SA1388 TIGR00486
dinuclear metal center protein, YbgI/SA1388 family; The characterization of this family of ...
27-372 6.12e-44

dinuclear metal center protein, YbgI/SA1388 family; The characterization of this family of uncharacterized proteins as orthologous is tentative. Members are found in all three domains of life. Several members (from Bacillus subtilis, Listeria monocytogenes, and Mycobacterium tuberculosis - all classified as Firmicutes within the Eubacteria) share a long insert relative to other members. [Unknown function, General]


Pssm-ID: 213534  Cd Length: 249  Bit Score: 152.54  E-value: 6.12e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433  27 MDLKALLSSLNDFASLSFAESWDNVGLLVEpSPPHTVNTLFLTNDLTEEVMEEALQKKADLILSYHPPIFRPMKHITWKT 106
Cdd:TIGR00486   1 MNLDELIQLINRFLPKELAEDGDNNGLQVG-SGNEEVKKVVVAVDASESVADEAVRLGADLIITHHPLIWKPLKRLIRGI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 107 WKERLVIrALENRVAIYSPHTAYDAAPQGVNSWLAKGLGtcttrpIHPSKapnyptegthrlefsanhsqdldkvmsavk 186
Cdd:TIGR00486  80 KPGRLKI-LLQNDISLYSAHTNLDAHDGGNNDALARALG------LENPK------------------------------ 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 187 gvggvsvtsfparcdgeeqtrvslnctqkalmqvlaflsqdrqlyqkteilSLEKPlllhtGMGRLCTLDESVSLATMIE 266
Cdd:TIGR00486 123 ---------------------------------------------------EFEDY-----GLGRVGEFKAPIESLEEVL 146
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 267 RIKRHLKLPHLRlalgVGRTLESPVKVVALCAGSGGS-----VLQGVeaDLYLTGEMSHHDVLDAASKGINVILCEHSNT 341
Cdd:TIGR00486 147 EIKKVLNVKPLL----VVKNGPEYVKKVAVVSGSGLSfimkaLREGV--DAYITGDLSHHTAHLARELGLNVIDAGHYAT 220
                         330       340       350
                  ....*....|....*....|....*....|.
gi 1996240433 342 ERGFLSDLQEMLgvHLENKINIILSETDRDP 372
Cdd:TIGR00486 221 ERGGLRKLMEDL--NENEGLEVVFSDIPTNA 249
PRK10799 PRK10799
type 2 GTP cyclohydrolase I;
255-356 2.04e-04

type 2 GTP cyclohydrolase I;


Pssm-ID: 182741  Cd Length: 247  Bit Score: 42.43  E-value: 2.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 255 LDESVSLATMIERIKRHLKlphlRLALGVGRTLESPVKVVALCAGSGGSVLQ-----GVEAdlYLTGEMSHHDVLDAASK 329
Cdd:PRK10799  133 LTMPVPGLELASWIEARLG----RKPLWCGDTGPEVVQRVAWCTGGGQSFIDsaarfGVDA--FITGEVSEQTIHSAREQ 206
                          90       100
                  ....*....|....*....|....*..
gi 1996240433 330 GINVILCEHSNTERGFLSDLQEMLGVH 356
Cdd:PRK10799  207 GLHFYAAGHHATERGGIRALSEWLNEN 233
 
Name Accession Description Interval E-value
NIF3 pfam01784
NIF3 (NGG1p interacting factor 3); This family contains several NIF3 (NGG1p interacting factor ...
32-353 2.01e-80

NIF3 (NGG1p interacting factor 3); This family contains several NIF3 (NGG1p interacting factor 3) protein homologs. NIF3 interacts with the yeast transcriptional coactivator NGG1p which is part of the ADA complex, the exact function of this interaction is unknown.


Pssm-ID: 426431  Cd Length: 236  Bit Score: 245.99  E-value: 2.01e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433  32 LLSSLNDFASLSFAESWDNVGLLVEpSPPHTVNTLFLTNDLTEEVMEEALQKKADLILSYHPPIFRPMKHITWKTWKERL 111
Cdd:pfam01784   2 IIELLEEIAPPELAEDWDNVGLQVG-DPENEVTKILVALDATEEVIEEAIENGADLIITHHPLIFRPLKSLTGDDPKGRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 112 VIRALENRVAIYSPHTAYDAAPQGVNSWLAKGLGTCTTRPIHPSKApnyptegthrlefsanhsqdldkvmsavkgvggv 191
Cdd:pfam01784  81 IKKLIKNNISLYSAHTNLDAAPGGVNDWLAELLGLESIEPLEPTEE---------------------------------- 126
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 192 svtsfparcdgeeqtrvslnctqkalmqvlaflsqdrqlyqkteilslekplllHTGMGRLCTLDESVSLATMIERIKRH 271
Cdd:pfam01784 127 ------------------------------------------------------GEGLGRIGELPEPMSLEELAAKVKEK 152
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 272 LKLPHLRLALGvgrtLESPVKVVALCAGSGGSVL---QGVEADLYLTGEMSHHDVLDAASKGINVILCEHSNTERGFLSD 348
Cdd:pfam01784 153 LGLEGVRVVGD----LDKPIKKVAICGGSGSSLIdeaKAKGADVLITGDVKYHDALDAQEKGINLIDAGHYATERFGLEA 228

                  ....*
gi 1996240433 349 LQEML 353
Cdd:pfam01784 229 LAELL 233
NIF3 COG0327
Putative GTP cyclohydrolase 1 type 2, NIF3 family [Coenzyme transport and metabolism]; ...
27-372 1.63e-56

Putative GTP cyclohydrolase 1 type 2, NIF3 family [Coenzyme transport and metabolism]; Putative GTP cyclohydrolase 1 type 2, NIF3 family is part of the Pathway/BioSystem: Folate biosynthesis


Pssm-ID: 440096  Cd Length: 254  Bit Score: 185.35  E-value: 1.63e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433  27 MDLKALLSSLNDFASLSFAESWDNVGLLV-EPSPPhtVNTLFLTNDLTEEVMEEALQKKADLILSYHPPIFRPMKHITWK 105
Cdd:COG0327     1 MTLSELVAALEELLPPALAESWDPNGLQVgEGRAE--VTRIVTAVDATQAVIEEAIEAGADLLIVHHPLFWKGEDSITAG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 106 TWKERLVIRALENRVAIYSPHTAYDAAPQ-GVNSWLAKGLGTCTTRPIHPSKApnyptegthrlefsanhsqdldkvmsa 184
Cdd:COG0327    79 TVKGRRLALLIKNDIALYAAHTPLDAHPElGNNAQLARLLGLEDVEPLGPSGG--------------------------- 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 185 vkgvggvsvtsfparcdgeeqtrvslnctqkalmqvlaflsqdrqlyqkteilslekplllhTGMGRLCTLDESVSLATM 264
Cdd:COG0327   132 --------------------------------------------------------------EGLGRIGELPEPMTLEEL 149
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 265 IERIKRHLKLPHLRLalgVGRtLESPVKVVALCAGSGGSVLQGVE---ADLYLTGEMSHHDVLDAASKGINVILCEHSNT 341
Cdd:COG0327   150 AARVKEALGLRGVRV---VGD-PDRPIRRVAICTGSGQSLIEEAAaagADAYITGEIKEHTAHDAREQGIALIDAGHYAT 225
                         330       340       350
                  ....*....|....*....|....*....|.
gi 1996240433 342 ERGFLSDLQEMLGVHLEnkINIILSETDRDP 372
Cdd:COG0327   226 ERPGVQALAEWLAEAFG--LEVEFIDIDNPP 254
YbgI_SA1388 TIGR00486
dinuclear metal center protein, YbgI/SA1388 family; The characterization of this family of ...
27-372 6.12e-44

dinuclear metal center protein, YbgI/SA1388 family; The characterization of this family of uncharacterized proteins as orthologous is tentative. Members are found in all three domains of life. Several members (from Bacillus subtilis, Listeria monocytogenes, and Mycobacterium tuberculosis - all classified as Firmicutes within the Eubacteria) share a long insert relative to other members. [Unknown function, General]


Pssm-ID: 213534  Cd Length: 249  Bit Score: 152.54  E-value: 6.12e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433  27 MDLKALLSSLNDFASLSFAESWDNVGLLVEpSPPHTVNTLFLTNDLTEEVMEEALQKKADLILSYHPPIFRPMKHITWKT 106
Cdd:TIGR00486   1 MNLDELIQLINRFLPKELAEDGDNNGLQVG-SGNEEVKKVVVAVDASESVADEAVRLGADLIITHHPLIWKPLKRLIRGI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 107 WKERLVIrALENRVAIYSPHTAYDAAPQGVNSWLAKGLGtcttrpIHPSKapnyptegthrlefsanhsqdldkvmsavk 186
Cdd:TIGR00486  80 KPGRLKI-LLQNDISLYSAHTNLDAHDGGNNDALARALG------LENPK------------------------------ 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 187 gvggvsvtsfparcdgeeqtrvslnctqkalmqvlaflsqdrqlyqkteilSLEKPlllhtGMGRLCTLDESVSLATMIE 266
Cdd:TIGR00486 123 ---------------------------------------------------EFEDY-----GLGRVGEFKAPIESLEEVL 146
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 267 RIKRHLKLPHLRlalgVGRTLESPVKVVALCAGSGGS-----VLQGVeaDLYLTGEMSHHDVLDAASKGINVILCEHSNT 341
Cdd:TIGR00486 147 EIKKVLNVKPLL----VVKNGPEYVKKVAVVSGSGLSfimkaLREGV--DAYITGDLSHHTAHLARELGLNVIDAGHYAT 220
                         330       340       350
                  ....*....|....*....|....*....|.
gi 1996240433 342 ERGFLSDLQEMLgvHLENKINIILSETDRDP 372
Cdd:TIGR00486 221 ERGGLRKLMEDL--NENEGLEVVFSDIPTNA 249
PRK10799 PRK10799
type 2 GTP cyclohydrolase I;
255-356 2.04e-04

type 2 GTP cyclohydrolase I;


Pssm-ID: 182741  Cd Length: 247  Bit Score: 42.43  E-value: 2.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1996240433 255 LDESVSLATMIERIKRHLKlphlRLALGVGRTLESPVKVVALCAGSGGSVLQ-----GVEAdlYLTGEMSHHDVLDAASK 329
Cdd:PRK10799  133 LTMPVPGLELASWIEARLG----RKPLWCGDTGPEVVQRVAWCTGGGQSFIDsaarfGVDA--FITGEVSEQTIHSAREQ 206
                          90       100
                  ....*....|....*....|....*..
gi 1996240433 330 GINVILCEHSNTERGFLSDLQEMLGVH 356
Cdd:PRK10799  207 GLHFYAAGHHATERGGIRALSEWLNEN 233
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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