nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), and similar proteins; ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a large transcription factor that functions at two levels, nuclear localization and DNA binding. It binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. ChREBP contains functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947  81 SIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVQRRKSPVCGFVTPLQGSEADEHRKP 160
Cdd:cd21771     1 SIDPTLTRLFECMSLAYSGKLVSPKWKNFKGLRLLWRDKIRLNNAIWRAWYIQYVEKRKNPVCGFVTPLEGSEADEHRKP 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1997057947 161 EAVVLEGNYWKRRIEVVMREYHKWRIYYKKRLRKSS 196
Cdd:cd21771    81 EAVVLEGNYWKRRIEVVMKEYHKWRIYYKKRLRKSS 116

large tegument protein UL36; Provisional

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947  262 PSPSSLQLPSEDAYVGNADmiQPDLTPLQPSLDDFMEISDFFTNYRPPQ-TPTSSNFPEPPSFG--PMADSLFSGGILGP 338
Cdd:PHA03247  2569 PPPRPAPRPSEPAVTSRAR--RPDAPPQSARPRAPVDDRGDPRGPAPPSpLPPDTHAPDPPPPSpsPAANEPDPHPPPTV 2646

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947  339 EMPSPASASSSSGMTPLSGNTRLQARNS-CSGP--------LDPSTFPSSEFLLPEDPKTkmPPAPVPTPLLPY----PG 405
Cdd:PHA03247  2647 PPPERPRDDPAPGRVSRPRRARRLGRAAqASSPpqrprrraARPTVGSLTSLADPPPPPP--TPEPAPHALVSAtplpPG 2724

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947  406 PVKVHGLEPCTP-SPFPTMAPPPALLSEEPLFSARFPFTTVPPAPGVSTLPA---PTTFVPTPQPGPVPGPVPFPVDHLP 481
Cdd:PHA03247  2725 PAAARQASPALPaAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAagpPRRLTRPAVASLSESRESLPSPWDP 2804

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947  482 HGYLEPVFGPHFTVPQGVQPrCKPCSPPPGGRKASPPTLTSATASPTATATARDNNpclTQLLRAAKPEQvlePSTVPST 561
Cdd:PHA03247  2805 ADPPAAVLAPAAALPPAASP-AGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPG---GDVRRRPPSRS---PAAKPAA 2877

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947  562 LLRPPESPQDAVPEIPRVRAFYPPIPAPTPPRPPPGPATLAPPRSLVVPKAERLSPPASSGSERRLSGDLNSIQPPGALS 641
Cdd:PHA03247  2878 PARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSG 2957

                          410
                   ....*....|....*
gi 1997057947  642 VHLSPPQTVLSRGRV 656
Cdd:PHA03247  2958 AVPQPWLGALVPGRV 2972

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), and similar proteins; ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a large transcription factor that functions at two levels, nuclear localization and DNA binding. It binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. ChREBP contains functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947  81 SIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVQRRKSPVCGFVTPLQGSEADEHRKP 160
Cdd:cd21771     1 SIDPTLTRLFECMSLAYSGKLVSPKWKNFKGLRLLWRDKIRLNNAIWRAWYIQYVEKRKNPVCGFVTPLEGSEADEHRKP 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1997057947 161 EAVVLEGNYWKRRIEVVMREYHKWRIYYKKRLRKSS 196
Cdd:cd21771    81 EAVVLEGNYWKRRIEVVMKEYHKWRIYYKKRLRKSS 116

Helix-loop-helix DNA-binding domain;

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1997057947 664 RRITHISAEQKRRFNIKLGFDTLHGLVSTLsaQPSLKVSKATTLQKTAEYILMLQ 718
Cdd:pfam00010   1 RREAHNERERRRRDRINDAFDELRELLPTL--PPDKKLSKAEILRLAIEYIKHLQ 53

large tegument protein UL36; Provisional

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947  262 PSPSSLQLPSEDAYVGNADmiQPDLTPLQPSLDDFMEISDFFTNYRPPQ-TPTSSNFPEPPSFG--PMADSLFSGGILGP 338
Cdd:PHA03247  2569 PPPRPAPRPSEPAVTSRAR--RPDAPPQSARPRAPVDDRGDPRGPAPPSpLPPDTHAPDPPPPSpsPAANEPDPHPPPTV 2646

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947  339 EMPSPASASSSSGMTPLSGNTRLQARNS-CSGP--------LDPSTFPSSEFLLPEDPKTkmPPAPVPTPLLPY----PG 405
Cdd:PHA03247  2647 PPPERPRDDPAPGRVSRPRRARRLGRAAqASSPpqrprrraARPTVGSLTSLADPPPPPP--TPEPAPHALVSAtplpPG 2724

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947  406 PVKVHGLEPCTP-SPFPTMAPPPALLSEEPLFSARFPFTTVPPAPGVSTLPA---PTTFVPTPQPGPVPGPVPFPVDHLP 481
Cdd:PHA03247  2725 PAAARQASPALPaAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAagpPRRLTRPAVASLSESRESLPSPWDP 2804

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947  482 HGYLEPVFGPHFTVPQGVQPrCKPCSPPPGGRKASPPTLTSATASPTATATARDNNpclTQLLRAAKPEQvlePSTVPST 561
Cdd:PHA03247  2805 ADPPAAVLAPAAALPPAASP-AGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPG---GDVRRRPPSRS---PAAKPAA 2877

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947  562 LLRPPESPQDAVPEIPRVRAFYPPIPAPTPPRPPPGPATLAPPRSLVVPKAERLSPPASSGSERRLSGDLNSIQPPGALS 641
Cdd:PHA03247  2878 PARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSG 2957

                          410
                   ....*....|....*
gi 1997057947  642 VHLSPPQTVLSRGRV 656
Cdd:PHA03247  2958 AVPQPWLGALVPGRV 2972

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), and similar proteins; ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a large transcription factor that functions at two levels, nuclear localization and DNA binding. It binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. ChREBP contains functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947  81 SIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVQRRKSPVCGFVTPLQGSEADEHRKP 160
Cdd:cd21771     1 SIDPTLTRLFECMSLAYSGKLVSPKWKNFKGLRLLWRDKIRLNNAIWRAWYIQYVEKRKNPVCGFVTPLEGSEADEHRKP 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1997057947 161 EAVVLEGNYWKRRIEVVMREYHKWRIYYKKRLRKSS 196
Cdd:cd21771    81 EAVVLEGNYWKRRIEVVMKEYHKWRIYYKKRLRKSS 116

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), MLX-interacting protein (MLXIP), and similar proteins; This family includes two transcription factors: ChREBP and MLXIP. ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), functions at two levels; nuclear localization and DNA binding. ChREBP binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. MLXIP, also called class E basic helix-loop-helix protein 36 (bHLHe36), transcriptional activator MondoA, or MIR, is a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. MLXIP binds DNA by forming a heterodimer with Max-like protein (MLX), and activates transcription. It binds to the canonical E box sequence 5'-CACGTG-3'. MLXIP plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation. Members in this family may contain functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947  81 SIDPTLTRLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVQRRKSPVCGFVTPLqgsEADEHRKP 160
Cdd:cd21739     1 AIDESLTKLFKCLTLAYSGKLTSPKWKNFKGLKLRWKDKIRLNNAIWREWHMQFVKKKKPPVCQFAVPL---DDDTHKKP 77

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1997057947 161 EAVVLEGNYWKRRIEVVMREYHKWRIYYKKRLRKSS 196
Cdd:cd21739    78 EAVVLEGKYWKRRLETVVREYKKWRLFYKDKLAGKT 113

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), MLX-interacting protein-like (MLXIPL) and similar proteins; The family includes MLXIP and MLXIPL. MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm. MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1997057947 662 ENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAAMQEEAQQLRDEI 735
Cdd:cd11405     1 EQRRLSHISAEQKRRFNIKSGFDTLQSLIPSLGQNPNQKVSKAAMLQKAAEYIKSLKRERQQMQEEAEQLRQEI 74

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar proteins; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1997057947 663 NRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQP---SLKVSKATTLQKTAEYILMLQQERAAMQEEAQQLRDEI 735
Cdd:cd19687     1 RRREAHTQAEQKRRDAIKKGYDDLQDIVPTCQQQDdigSQKLSKATILQRSIDYIQFLHQQKKKQEEELSALRKEV 76

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain).

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1997057947 664 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPslKVSKATTLQKTAEYILMLQQERAAMQEEAQQLRDEIEELNA 740
Cdd:cd11400     1 KRRLHNVLERQRRNDLKNSFEKLRDLVPELADNE--KASKVVILKKATEYIKQLQQEEKKLEKEKDKLKARNEQLRK 75

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family and similar proteins; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box. The family also includes Saccharomyces cerevisiae transcription factor HMS1 (also termed high-copy MEP suppressor protein 1) and serine-rich protein TYE7. HMS1 is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation. TYE7, also termed basic-helix-loop-helix protein SGC1, is a putative bHLHzip transcription activator required for Ty1-mediated glycolytic gene expression. TYE7 N-terminal is extremely rich in serine residues. It binds DNA on E-box motifs, 5'-CANNTG-3'. TYE7 is not essential for growth.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947 662 ENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQ-------------PSLKVSKATTLQKTAEYILMLQQERAAMQEEA 728
Cdd:cd11395     1 PRKRLPHNAIEKRYRSNLNTKIERLRDAIPSLRSPegksddgglgglaPTTKLSKATILTKAIEYIRHLEQENERLEEEN 80

                  ....*..
gi 1997057947 729 QQLRDEI 735
Cdd:cd11395    81 EELRQQV 87

basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and similar proteins; INO2 is a positive regulatory factor required for depression of the co-regulated phospholipid biosynthetic enzymes in Saccharomyces cerevisiae. It is also involved in the expression of ITR1.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1997057947 664 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAAMQEEA 728
Cdd:cd11388     3 KKWKHVEAEKKRRNQIKKGFEDLINLINYPRNNNEKRISKSELLNKAVDDIRGLLKANEQLQEEI 67

basic Helix-Loop-Helix (bHLH) domain found in Saccharomyces cerevisiae INO4 and similar proteins; INO4 is a bHLH transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.). It is required for de-repression of phospholipid biosynthetic gene expression in response to inositol deprivation in yeast. INO4 dimerizes with INO2 and binds to an UAS DNA element to control expression of the genes whose expression is inositol-responsive.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1997057947 664 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLkvSKATTLQKTAEYILMLQQERAAMQEEA 728
Cdd:cd11403     2 KKENHISSEHKRREAIREGFDRLCAIVPALSSSQSR--SEAVVYVKTVEYLKELYERRAKLRSQL 64

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins; TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1997057947 664 RRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQpslKVSKATTLQKTAEYILMLQQERAAM 724
Cdd:cd11419     4 RREIANSNERRRMQSINAGFQSLRTLLPHCDGE---KLSKAAILQQTAEYIFSLEQEKTRL 61

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) family; The MGA family includes MGA, Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins. MGA, also termed MAX dimerization protein 5 (MAD5), is a dual specificity T-box/ bHLHzip transcription factor that regulates the expression of both Max-network and T-box family target genes. It contains a Myc-like bHLHZip motif and requires heterodimerization with Max for binding to the preferred Myc-Max-binding site CACGTG. In addition to the bHLHZip domain, MGA harbors a second DNA-binding domain, the T-box or T-domain. It thus binds the preferred Brachyury-binding sequence and represses transcription of reporter genes containing promoter-proximal Brachyury-binding sites. spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1997057947 665 RITHISAEQKRRFNIKLGFDTLHGLVsTLSAQPslKVSKATTLQKTAEYILMLQQERAAMQEEAQQLR 732
Cdd:cd19682     1 RLRHKKRERERRSELRELFDKLKQLL-GLDSDE--KASKLAVLTEAIEEIQQLKREEDELQKEKARLT 65

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in c-Myc and similar proteins; c-Myc, also termed Myc proto-oncogene protein, or Class E basic helix-loop-helix protein 39 (bHLHe39), or transcription factor p64, a bHLHZip proto-oncogene protein that functions as a transcription factor, which binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. It activates the transcription of growth-related genes.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1997057947 660 KMENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPslKVSKATTLQKTAEYILMLQQERAAMQEEAQQLRDEIEEL 738
Cdd:cd11458     1 EENDKRRTHNVLERQRRNELKLSFFALRDQIPEVANNE--KAPKVVILKKATEYILSMQADEQRLISEKEQLRRRREQL 77

basic helix-loop-helix (bHLH) domain found in achaete-scute complex-like (ASCL) family; The achaete-scute complex-like (ASCL, also known as achaete-scute complex homolog or ASH) family of bHLH transcription factors, ASCL1-5, have been implicated in cell fate specification and differentiation. They are critical for proper development of the nervous system. The deregulation of ASCL plays a key role in psychiatric and neurological disorders. ASCL-1, also termed Class A basic helix-loop-helix protein 46 (bHLHa46), or achaete-scute homolog 1 (ASH-1), or mammalian achaete-scute homolog 1 (Mash1), is a neural-specific bHLH transcription factor that is expressed in subsets of neural progenitors in both the central and peripheral nervous system. It plays a key role in neuronal differentiation and specification in the nervous system. ASCL-2, also termed achaete-scute homolog 2 (ASH-2), or Class A basic helix-loop-helix protein 45 (bHLHa45), or mammalian achaete-scute homolog 2 (Mash2), is a bHLH transcription factor that is involved in Schwann cell differentiation and control of proliferation in adult peripheral nerves. ASCL-3, also termed Class A basic helix-loop-helix protein 42 (bHLHa42), or bHLH transcriptional regulator Sgn-1, or achaete-scute homolog 3 (ASH-3), is a bHLH transcription factor specifically localized in the duct cells of the salivary glands. It may act as transcriptional repressor that inhibits myogenesis. The family also includes Drosophila melanogaster achaete-scute complex (AS-C) proteins, which consists of lethal of scute (also known as achaete-scute complex protein T3 or AST3), scute (also known as achaete-scute complex protein T4 or AST4), achaete (also known as achaete-scute complex protein T5 or AST5), and asense (also known as achaete-scute complex protein T8 or AST8). They are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system, as well as in sex determination and dosage compensation.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1997057947 659 NKMENRRITHISaeqkrrfnikLGFDTLHGLVSTLSaqPSLKVSKATTLQKTAEYILMLQQE 720
Cdd:cd11418     6 NERERRRVQAVN----------DAFDRLRQHVPYLK--RRKKLSKVKTLRRAIEYIRHLQKL 55

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins; TFE3, also termed Class E basic helix-loop-helix protein 33 (bHLHe33), is a bHLHzip transcription factor that is involved in B cell function. It specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Its efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947 660 KMENRRITHISAEQKRRFNIKLGFDTLHGLVSTlSAQPSLKVSKATTLQKTAEYILMLQQERAAMQEEAQQLRdEIEELN 739
Cdd:cd18928     7 KERQKKDNHNLIERRRRFNINDRIKELGTLIPK-STDPEMRWNKGTILKASVDYIRKLQKEQQRSKEIEMRQR-KLEQAN 84

                  ....*
gi 1997057947 740 AAINL 744
Cdd:cd18928    85 RSLQL 89

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae transcription factor HMS1 and similar proteins; HMS1, also termed high-copy MEP suppressor protein 1, is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947 663 NRRITHIS-------AEQKRRFNIKLGFDTLHGLvstlsaQPSLKVSKATTLQKTAEYILMLQQERAAMQEEAQQLRDEI 735
Cdd:cd11399    19 NDRIAELRdsvpalrEAYKSARGEDEDEEDLGGL------TPATKLNKATILSKATEYIRHLEKKNKRLSRENASLRERL 92

                  ...
gi 1997057947 736 EEL 738
Cdd:cd11399    93 AAH 95

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EC (TFEC) and similar proteins; TFEC, also termed Class E basic helix-loop-helix protein 34 (bHLHe34), or transcription factor EC-like (TFEC-L), is a bHLHzip transcriptional regulator that acts as a repressor or an activator and regulates gene expression in macrophages. It plays an important role in the niche to expand hematopoietic progenitors through the modulation of several cytokines.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947 660 KMENRRITHISAEQKRRFNIKLGFDTLHGLVSTlSAQPSLKVSKATTLQKTAEYILMLQQEraamQEEAQQLRDEIEELN 739
Cdd:cd18925     1 KERQKKDNHNLIERRRRYNINYRIKELGTLIPK-SNDPDMRWNKGTILKASVEYIKWLQKE----QQRARELEHRQKKLE 75

                  ..
gi 1997057947 740 AA 741
Cdd:cd18925    76 QA 77

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins; MITF, also termed Class E basic helix-loop-helix protein 32 (bHLHe32), is a bHLHzip transcription factor that is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. It regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. It binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947 660 KMENRRITHISAEQKRRFNIKLGFDTLHGLVSTlSAQPSLKVSKATTLQKTAEYILMLQQEraamQEEAQQLRDEIEELN 739
Cdd:cd18926     9 KERQKKDNHNLIERRRRFNINDRIKELGTLIPK-SNDPDMRWNKGTILKASVDYIRKLQRE----QQRAKELENRQKKLE 83

                  ..
gi 1997057947 740 AA 741
Cdd:cd18926    84 HA 85

large tegument protein UL36; Provisional

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947  369 GPLDPSTFPSSEFLLPEDPKTkmPPAP-VPTPLLPYPGPVK----------VHGLEPCT-------PSPFPTMAPP---- 426
Cdd:PHA03247  2488 FPFAAGAAPDPGGGGPPDPDA--PPAPsRLAPAILPDEPVGepvhprmltwIRGLEELAsddagdpPPPLPPAAPPaapd 2565

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947  427 -------PALLSEEPLFSARFPFTTVPP------APGVSTLPAPTTFVPTPQPGPVPGPVPFPVDHLPHGYlEPVFGPHF 493
Cdd:PHA03247  2566 rsvppprPAPRPSEPAVTSRARRPDAPPqsarprAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAAN-EPDPHPPP 2644

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947  494 TVPQGVQPRCKPC----SPPPGGRKASPPTLTSATASPTATATARDNNPCLTQLLRAAKPEQVLEP---STVPSTLLRP- 565
Cdd:PHA03247  2645 TVPPPERPRDDPApgrvSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPaphALVSATPLPPg 2724

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1997057947  566 --------PESPQD-AVPEIPRVRAFYPPIPAPTPPRPPPGPATLAPPRSLVVPKAERLSPPASSGserrLSGDLNSIQP 636
Cdd:PHA03247  2725 paaarqasPALPAApAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVAS----LSESRESLPS 2800

                          330
                   ....*....|
gi 1997057947  637 PGALSVHLSP 646
Cdd:PHA03247  2801 PWDPADPPAA 2810

tissue specific basic helix-loop-helix (bHLH-TS) domain family; Tissue specific bHLH domain family includes transcription regulators whose expression are restricted to certain tissues. They are involved in cell-fate determination and process in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis and include proteins from myogenic regulatory factor (MRF) family, twist-related protein (TWIST) family, scleraxis-like family, heart- and neural crest derivatives-expressed protein (HAND) family, helix-loop-helix protein (HEN) family, musculin-like family, germline alpha (FIGLA) family, T-cell acute lymphocytic leukemia protein/ lymphoblastic leukemia-derived sequence (TAL/LYL) family, ovary, uterus and testis protein (OUT) family, mesoderm posterior protein (Mesp) family, muscle, intestine and stomach expression 1 (MIST-1) family, protein atonal homologs (ATOH) family, neurogenin (NGN) family, neurogenic differentiation factor (NeuroD) family, achaete-scute complex-like (ASCL) family, Fer3-like protein (FERD3L)-like family, and Oligodendrocyte lineage genes (OLIG) family of transcription factors.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1997057947 665 RITHISAEQKRRFNIKLGFDTLHGLVSTLsaQPSLKVSKATTLQKTAEYILMLQQ 719
Cdd:cd11390     1 RNAANARERRRMHDLNDAFEALRKVLPTV--PPDKKLSKIETLRLAINYIAALSD 53