protein KRBA1 isoform 3 [Homo sapiens]
KRAB domain-containing protein( domain architecture ID 11116080)
KRAB (Kruppel-associated box) domain-containing protein may function as a transcriptional repressor when tethered to the template DNA by a DNA-binding domain; also contains KRBA1 family repeats
List of domain hits
Name | Accession | Description | Interval | E-value | |||||||
KRAB | pfam01352 | KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ... |
6-47 | 2.69e-19 | |||||||
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation. : Pssm-ID: 460171 Cd Length: 42 Bit Score: 81.75 E-value: 2.69e-19
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KRBA1 | pfam15287 | KRBA1 family repeat; KRBA1 is a short repeating motif found in mammalian proteins. It is ... |
245-287 | 8.17e-09 | |||||||
KRBA1 family repeat; KRBA1 is a short repeating motif found in mammalian proteins. It is characterized by a highly conserved sequence of residues, SSPLxxLxxCLK. The function of the repeat, which can be present in up to seven copies, is unknown as is the function of the full length proteins. : Pssm-ID: 464615 Cd Length: 44 Bit Score: 52.41 E-value: 8.17e-09
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PHA03247 super family | cl33720 | large tegument protein UL36; Provisional |
128-573 | 1.87e-05 | |||||||
large tegument protein UL36; Provisional The actual alignment was detected with superfamily member PHA03247: Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.17 E-value: 1.87e-05
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Name | Accession | Description | Interval | E-value | |||||||
KRAB | pfam01352 | KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ... |
6-47 | 2.69e-19 | |||||||
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation. Pssm-ID: 460171 Cd Length: 42 Bit Score: 81.75 E-value: 2.69e-19
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KRAB_A-box | cd07765 | KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ... |
7-45 | 1.54e-18 | |||||||
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation. Pssm-ID: 143639 Cd Length: 40 Bit Score: 79.90 E-value: 1.54e-18
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KRAB | smart00349 | krueppel associated box; |
8-64 | 3.51e-18 | |||||||
krueppel associated box; Pssm-ID: 214630 [Multi-domain] Cd Length: 61 Bit Score: 79.17 E-value: 3.51e-18
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KRBA1 | pfam15287 | KRBA1 family repeat; KRBA1 is a short repeating motif found in mammalian proteins. It is ... |
245-287 | 8.17e-09 | |||||||
KRBA1 family repeat; KRBA1 is a short repeating motif found in mammalian proteins. It is characterized by a highly conserved sequence of residues, SSPLxxLxxCLK. The function of the repeat, which can be present in up to seven copies, is unknown as is the function of the full length proteins. Pssm-ID: 464615 Cd Length: 44 Bit Score: 52.41 E-value: 8.17e-09
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PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
128-573 | 1.87e-05 | |||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.17 E-value: 1.87e-05
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KRBA1 | pfam15287 | KRBA1 family repeat; KRBA1 is a short repeating motif found in mammalian proteins. It is ... |
421-465 | 1.13e-03 | |||||||
KRBA1 family repeat; KRBA1 is a short repeating motif found in mammalian proteins. It is characterized by a highly conserved sequence of residues, SSPLxxLxxCLK. The function of the repeat, which can be present in up to seven copies, is unknown as is the function of the full length proteins. Pssm-ID: 464615 Cd Length: 44 Bit Score: 37.78 E-value: 1.13e-03
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Name | Accession | Description | Interval | E-value | |||||||
KRAB | pfam01352 | KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ... |
6-47 | 2.69e-19 | |||||||
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation. Pssm-ID: 460171 Cd Length: 42 Bit Score: 81.75 E-value: 2.69e-19
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KRAB_A-box | cd07765 | KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ... |
7-45 | 1.54e-18 | |||||||
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation. Pssm-ID: 143639 Cd Length: 40 Bit Score: 79.90 E-value: 1.54e-18
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KRAB | smart00349 | krueppel associated box; |
8-64 | 3.51e-18 | |||||||
krueppel associated box; Pssm-ID: 214630 [Multi-domain] Cd Length: 61 Bit Score: 79.17 E-value: 3.51e-18
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KRBA1 | pfam15287 | KRBA1 family repeat; KRBA1 is a short repeating motif found in mammalian proteins. It is ... |
245-287 | 8.17e-09 | |||||||
KRBA1 family repeat; KRBA1 is a short repeating motif found in mammalian proteins. It is characterized by a highly conserved sequence of residues, SSPLxxLxxCLK. The function of the repeat, which can be present in up to seven copies, is unknown as is the function of the full length proteins. Pssm-ID: 464615 Cd Length: 44 Bit Score: 52.41 E-value: 8.17e-09
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PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
128-573 | 1.87e-05 | |||||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.17 E-value: 1.87e-05
|
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KRBA1 | pfam15287 | KRBA1 family repeat; KRBA1 is a short repeating motif found in mammalian proteins. It is ... |
421-465 | 1.13e-03 | |||||||
KRBA1 family repeat; KRBA1 is a short repeating motif found in mammalian proteins. It is characterized by a highly conserved sequence of residues, SSPLxxLxxCLK. The function of the repeat, which can be present in up to seven copies, is unknown as is the function of the full length proteins. Pssm-ID: 464615 Cd Length: 44 Bit Score: 37.78 E-value: 1.13e-03
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KRBA1 | pfam15287 | KRBA1 family repeat; KRBA1 is a short repeating motif found in mammalian proteins. It is ... |
542-573 | 1.74e-03 | |||||||
KRBA1 family repeat; KRBA1 is a short repeating motif found in mammalian proteins. It is characterized by a highly conserved sequence of residues, SSPLxxLxxCLK. The function of the repeat, which can be present in up to seven copies, is unknown as is the function of the full length proteins. Pssm-ID: 464615 Cd Length: 44 Bit Score: 37.39 E-value: 1.74e-03
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Blast search parameters | ||||
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