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Conserved domains on  [gi|2033030975|ref|NP_001381726|]
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integrator complex subunit 14 isoform 5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IntS14_b-barrel pfam19435
Integrator complex subunit 14, beta-barrel domain; This entry represents the central ...
 173-320 4.16e-96

Integrator complex subunit 14, beta-barrel domain; This entry represents the central beta-barrel domain of Integrator complex subunit 14 (IntS14), a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5. IntS14 interacts with IntS13, both of them consist of an N-terminal von-Willebrand type A like domain (VWA), followed by a central beta-barrel domain and a C-terminal alpha-helical domain connected through a linker. The interface involves all domains of both proteins, both beta-barrel domains form the centre of the complex and contribute to the major contact between Ints13-IntS14.


:

Pssm-ID: 466081  Cd Length: 147  Bit Score: 286.47  E-value: 4.16e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030975 173 YTPFHAVLKCGHLTADVQVFPRPEPFVVDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGTG 252
Cdd:pfam19435   1 YSPFHGTLKCGNLSSPVQLFPPPEPYTKDTDFEPITRTISDDIEICGFIDIADVASPPVISRHLVLPLSTKKEKDESGKG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2033030975 253 ITDDnEDENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPEWHGMLYSQADSKKKSNLMMSLFEPG 320
Cdd:pfam19435  81 GKAG-EDEDESNTDEGKIPSFCVLLHGSLKVENMVALVQVGEDWYGMLYSWADSKKKSNLMLSIFEPG 147
IntS14_C pfam20504
Integrator complex subunit 14, alpha-helical domain; This entry represents the C-terminal ...
 369-476 9.07e-67

Integrator complex subunit 14, alpha-helical domain; This entry represents the C-terminal alpha-helical domain of Integrator complex subunit 14 (IntS14), a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5. IntS14 interacts with IntS13; both of them consist of an N-terminal VWA domain followed by a central beta-barrel domain and a C-terminal alpha-helical domain, which are connected through a linker devoid of secondary structure elements. This domain contribute to binding by packing against the beta-barrel of IntS13.


:

Pssm-ID: 466653  Cd Length: 103  Bit Score: 209.49  E-value: 9.07e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030975 369 VWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPETAHPDAAFQLTHAAQ 448
Cdd:pfam20504   1 VWIKPGGLQSDIQKILRHARKLPEKTQQFYKELNRLRRAALSFGFLELLEGLAAMLERECTLLPGTAHPDAALQLTHAAN 80

                          90       100
                  ....*....|....*....|....*...
gi 2033030975 449 QLKLastgtSEYAAYDQNITPLHTDFSG 476
Cdd:pfam20504  81 QLRK-----SQSRDYKYNITPLQTNFSG 103
VWA_2 pfam13519
von Willebrand factor type A domain;
3-74 1.29e-09

von Willebrand factor type A domain;


:

Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 55.38  E-value: 1.29e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2033030975   3 TVVVMDVSLSMTRpvsieGSEEYQRKHLAAHGLTMLFEHMATNykleFTALVVFSSLWELMVPFTRDYNTLQ 74
Cdd:pfam13519   1 LVFVLDTSGSMRN-----GDYGPTRLEAAKDAVLALLKSLPGD----RVGLVTFGDGPEVLIPLTKDRAKIL 63
 
Name Accession Description Interval E-value
IntS14_b-barrel pfam19435
Integrator complex subunit 14, beta-barrel domain; This entry represents the central ...
 173-320 4.16e-96

Integrator complex subunit 14, beta-barrel domain; This entry represents the central beta-barrel domain of Integrator complex subunit 14 (IntS14), a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5. IntS14 interacts with IntS13, both of them consist of an N-terminal von-Willebrand type A like domain (VWA), followed by a central beta-barrel domain and a C-terminal alpha-helical domain connected through a linker. The interface involves all domains of both proteins, both beta-barrel domains form the centre of the complex and contribute to the major contact between Ints13-IntS14.


Pssm-ID: 466081  Cd Length: 147  Bit Score: 286.47  E-value: 4.16e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030975 173 YTPFHAVLKCGHLTADVQVFPRPEPFVVDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGTG 252
Cdd:pfam19435   1 YSPFHGTLKCGNLSSPVQLFPPPEPYTKDTDFEPITRTISDDIEICGFIDIADVASPPVISRHLVLPLSTKKEKDESGKG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2033030975 253 ITDDnEDENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPEWHGMLYSQADSKKKSNLMMSLFEPG 320
Cdd:pfam19435  81 GKAG-EDEDESNTDEGKIPSFCVLLHGSLKVENMVALVQVGEDWYGMLYSWADSKKKSNLMLSIFEPG 147
IntS14_C pfam20504
Integrator complex subunit 14, alpha-helical domain; This entry represents the C-terminal ...
 369-476 9.07e-67

Integrator complex subunit 14, alpha-helical domain; This entry represents the C-terminal alpha-helical domain of Integrator complex subunit 14 (IntS14), a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5. IntS14 interacts with IntS13; both of them consist of an N-terminal VWA domain followed by a central beta-barrel domain and a C-terminal alpha-helical domain, which are connected through a linker devoid of secondary structure elements. This domain contribute to binding by packing against the beta-barrel of IntS13.


Pssm-ID: 466653  Cd Length: 103  Bit Score: 209.49  E-value: 9.07e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030975 369 VWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPETAHPDAAFQLTHAAQ 448
Cdd:pfam20504   1 VWIKPGGLQSDIQKILRHARKLPEKTQQFYKELNRLRRAALSFGFLELLEGLAAMLERECTLLPGTAHPDAALQLTHAAN 80

                          90       100
                  ....*....|....*....|....*...
gi 2033030975 449 QLKLastgtSEYAAYDQNITPLHTDFSG 476
Cdd:pfam20504  81 QLRK-----SQSRDYKYNITPLQTNFSG 103
VWA_2 pfam13519
von Willebrand factor type A domain;
3-74 1.29e-09

von Willebrand factor type A domain;


Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 55.38  E-value: 1.29e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2033030975   3 TVVVMDVSLSMTRpvsieGSEEYQRKHLAAHGLTMLFEHMATNykleFTALVVFSSLWELMVPFTRDYNTLQ 74
Cdd:pfam13519   1 LVFVLDTSGSMRN-----GDYGPTRLEAAKDAVLALLKSLPGD----RVGLVTFGDGPEVLIPLTKDRAKIL 63
idnK PRK09825
gluconokinase;
329-453 6.78e-04

gluconokinase;


Pssm-ID: 182097  Cd Length: 176  Bit Score: 40.39  E-value: 6.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030975 329 KMAQLGPISDAKENPYGEDDNKSPFPLqpknkrsYAQNVTVWIKPSGLQTDVQKILRNARK------LPEKTQTFykeLN 402
Cdd:PRK09825   45 KMSQGIPLTDEDRLPWLERLNDASYSL-------YKKNETGFIVCSSLKKQYRDILRKSSPnvhflwLDGDYETI---LA 114

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2033030975 403 RLRKAALAFGFLDLLKGVADMLERECTLLPETAHPDAAFQLTHAAQQLKLA 453
Cdd:PRK09825  115 RMQRRAGHFMPPDLLQSQFDALERPCADEHDIARIDVNHDIENVTEQCRQA 165
 
Name Accession Description Interval E-value
IntS14_b-barrel pfam19435
Integrator complex subunit 14, beta-barrel domain; This entry represents the central ...
 173-320 4.16e-96

Integrator complex subunit 14, beta-barrel domain; This entry represents the central beta-barrel domain of Integrator complex subunit 14 (IntS14), a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5. IntS14 interacts with IntS13, both of them consist of an N-terminal von-Willebrand type A like domain (VWA), followed by a central beta-barrel domain and a C-terminal alpha-helical domain connected through a linker. The interface involves all domains of both proteins, both beta-barrel domains form the centre of the complex and contribute to the major contact between Ints13-IntS14.


Pssm-ID: 466081  Cd Length: 147  Bit Score: 286.47  E-value: 4.16e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030975 173 YTPFHAVLKCGHLTADVQVFPRPEPFVVDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGTG 252
Cdd:pfam19435   1 YSPFHGTLKCGNLSSPVQLFPPPEPYTKDTDFEPITRTISDDIEICGFIDIADVASPPVISRHLVLPLSTKKEKDESGKG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2033030975 253 ITDDnEDENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPEWHGMLYSQADSKKKSNLMMSLFEPG 320
Cdd:pfam19435  81 GKAG-EDEDESNTDEGKIPSFCVLLHGSLKVENMVALVQVGEDWYGMLYSWADSKKKSNLMLSIFEPG 147
IntS14_C pfam20504
Integrator complex subunit 14, alpha-helical domain; This entry represents the C-terminal ...
 369-476 9.07e-67

Integrator complex subunit 14, alpha-helical domain; This entry represents the C-terminal alpha-helical domain of Integrator complex subunit 14 (IntS14), a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5. IntS14 interacts with IntS13; both of them consist of an N-terminal VWA domain followed by a central beta-barrel domain and a C-terminal alpha-helical domain, which are connected through a linker devoid of secondary structure elements. This domain contribute to binding by packing against the beta-barrel of IntS13.


Pssm-ID: 466653  Cd Length: 103  Bit Score: 209.49  E-value: 9.07e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030975 369 VWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPETAHPDAAFQLTHAAQ 448
Cdd:pfam20504   1 VWIKPGGLQSDIQKILRHARKLPEKTQQFYKELNRLRRAALSFGFLELLEGLAAMLERECTLLPGTAHPDAALQLTHAAN 80

                          90       100
                  ....*....|....*....|....*...
gi 2033030975 449 QLKLastgtSEYAAYDQNITPLHTDFSG 476
Cdd:pfam20504  81 QLRK-----SQSRDYKYNITPLQTNFSG 103
VWA_2 pfam13519
von Willebrand factor type A domain;
3-74 1.29e-09

von Willebrand factor type A domain;


Pssm-ID: 463909 [Multi-domain]  Cd Length: 103  Bit Score: 55.38  E-value: 1.29e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2033030975   3 TVVVMDVSLSMTRpvsieGSEEYQRKHLAAHGLTMLFEHMATNykleFTALVVFSSLWELMVPFTRDYNTLQ 74
Cdd:pfam13519   1 LVFVLDTSGSMRN-----GDYGPTRLEAAKDAVLALLKSLPGD----RVGLVTFGDGPEVLIPLTKDRAKIL 63
idnK PRK09825
gluconokinase;
329-453 6.78e-04

gluconokinase;


Pssm-ID: 182097  Cd Length: 176  Bit Score: 40.39  E-value: 6.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2033030975 329 KMAQLGPISDAKENPYGEDDNKSPFPLqpknkrsYAQNVTVWIKPSGLQTDVQKILRNARK------LPEKTQTFykeLN 402
Cdd:PRK09825   45 KMSQGIPLTDEDRLPWLERLNDASYSL-------YKKNETGFIVCSSLKKQYRDILRKSSPnvhflwLDGDYETI---LA 114

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2033030975 403 RLRKAALAFGFLDLLKGVADMLERECTLLPETAHPDAAFQLTHAAQQLKLA 453
Cdd:PRK09825  115 RMQRRAGHFMPPDLLQSQFDALERPCADEHDIARIDVNHDIENVTEQCRQA 165
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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