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Conserved domains on  [gi|2077860273|ref|NP_001382697|]
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Anaphase-promoting complex subunit 4-like WD40 domain-containing protein [Caenorhabditis elegans]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
348-693 1.63e-46

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.09  E-value: 1.63e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 348 ATTTATSPFGGPFGVDSQRLLRTPRKPIRKVPKNPYKVLDAPELQDDFYLNLVDWSSQNQ--LSVGLAACVYLWSATTSQ 425
Cdd:COG2319    32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRllASASADGTVRLWDLATGL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 426 VIKLcdlgQTNEQDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKKTRELTGHSSRVGCLAWNAD--TICSGSRDRTIM 503
Cdd:COG2319   112 LLRT----LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVR 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 504 HRDIrcDDNDMGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQHNAAVKALAWSPHHHgLLVSG 583
Cdd:COG2319   188 LWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGR-LLASG 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 584 GgtADRCLRFWNTLTAQPMQCVDT-GSQVCNVAWSKHSSELVSThgySFNHlQVIIWKYPSLQPVTKLVGHQYRVLYLAM 662
Cdd:COG2319   265 S--ADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLASG---SDDG-TVRLWDLATGKLLRTLTGHTGAVRSVAF 338

                         330       340       350
                  ....*....|....*....|....*....|.
gi 2077860273 663 SPDGESIVTGAGDETLRFWHVFNKGNPPTIT 693
Cdd:COG2319   339 SPDGKTLASGSDDGTVRLWDLATGELLRTLT 369
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
348-693 1.63e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.09  E-value: 1.63e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 348 ATTTATSPFGGPFGVDSQRLLRTPRKPIRKVPKNPYKVLDAPELQDDFYLNLVDWSSQNQ--LSVGLAACVYLWSATTSQ 425
Cdd:COG2319    32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRllASASADGTVRLWDLATGL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 426 VIKLcdlgQTNEQDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKKTRELTGHSSRVGCLAWNAD--TICSGSRDRTIM 503
Cdd:COG2319   112 LLRT----LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVR 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 504 HRDIrcDDNDMGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQHNAAVKALAWSPHHHgLLVSG 583
Cdd:COG2319   188 LWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGR-LLASG 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 584 GgtADRCLRFWNTLTAQPMQCVDT-GSQVCNVAWSKHSSELVSThgySFNHlQVIIWKYPSLQPVTKLVGHQYRVLYLAM 662
Cdd:COG2319   265 S--ADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLASG---SDDG-TVRLWDLATGKLLRTLTGHTGAVRSVAF 338

                         330       340       350
                  ....*....|....*....|....*....|.
gi 2077860273 663 SPDGESIVTGAGDETLRFWHVFNKGNPPTIT 693
Cdd:COG2319   339 SPDGKTLASGSDDGTVRLWDLATGELLRTLT 369
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 400-681 1.76e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 166.74  E-value: 1.76e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 400 VDWSSQNQlsvglaacvYLWSATTSQVIKLCDL-------GQTNEQDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKK 472
Cdd:cd00200    15 VAFSPDGK---------LLATGSGDGTIKVWDLetgellrTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 473 TRELTGHSSRVGCLAWNADT--ICSGSRDRTIMHRDIRcdDNDMGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWN 550
Cdd:cd00200    86 VRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVE--TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 551 LRRNEPIQTYTQHNAAVKALAWSPHHHGLLVSGGgtaDRCLRFWNTLTAqpmQCVDT----GSQVCNVAWSKHSSELVSt 626
Cdd:cd00200   164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS---DGTIKLWDLSTG---KCLGTlrghENGVNSVAFSPDGYLLAS- 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2077860273 627 hgYSFNHLqVIIWKYPSLQPVTKLVGHQYRVLYLAMSPDGESIVTGAGDETLRFW 681
Cdd:cd00200   237 --GSEDGT-IRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 522-681 1.55e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.63  E-value: 1.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 522 RQEVCGLKW-SPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQHNAAVKALAWSPHHHGLLVSggGTADRCLRFWNTLTAQ 600
Cdd:PLN00181  532 RSKLSGICWnSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLAS--GSDDGSVKLWSINQGV 609

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 601 PMQCVDTGSQVCNVAWSKHSSELVStHGYSFNHLQVIIWKYPSLqPVTKLVGHQYRVLYLAMSpDGESIVTGAGDETLRF 680
Cdd:PLN00181  610 SIGTIKTKANICCVQFPSESGRSLA-FGSADHKVYYYDLRNPKL-PLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKL 686


                  .
gi 2077860273 681 W 681
Cdd:PLN00181  687 W 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 516-550 1.90e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.90e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2077860273  516 RKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWN 550
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 444-573 1.82e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 43.81  E-value: 1.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 444 VQWCDKGDLLAVGTSRGvtQIWdvttqkkTRELTGHssRVgclaWnadticsgsrdrtimhrdircddndmGRKLTNHRQ 523
Cdd:pfam12894   1 MSWCPTMDLIALATEDG--ELL-------LHRLNWQ--RV----W--------------------------TLSPDKEDL 39

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2077860273 524 EVCGLKWSPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQHNAAVKALAWS 573
Cdd:pfam12894  40 EVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
348-693 1.63e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.09  E-value: 1.63e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 348 ATTTATSPFGGPFGVDSQRLLRTPRKPIRKVPKNPYKVLDAPELQDDFYLNLVDWSSQNQ--LSVGLAACVYLWSATTSQ 425
Cdd:COG2319    32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRllASASADGTVRLWDLATGL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 426 VIKLcdlgQTNEQDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKKTRELTGHSSRVGCLAWNAD--TICSGSRDRTIM 503
Cdd:COG2319   112 LLRT----LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVR 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 504 HRDIrcDDNDMGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQHNAAVKALAWSPHHHgLLVSG 583
Cdd:COG2319   188 LWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGR-LLASG 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 584 GgtADRCLRFWNTLTAQPMQCVDT-GSQVCNVAWSKHSSELVSThgySFNHlQVIIWKYPSLQPVTKLVGHQYRVLYLAM 662
Cdd:COG2319   265 S--ADGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLASG---SDDG-TVRLWDLATGKLLRTLTGHTGAVRSVAF 338

                         330       340       350
                  ....*....|....*....|....*....|.
gi 2077860273 663 SPDGESIVTGAGDETLRFWHVFNKGNPPTIT 693
Cdd:COG2319   339 SPDGKTLASGSDDGTVRLWDLATGELLRTLT 369
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 400-681 1.76e-46

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 166.74  E-value: 1.76e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 400 VDWSSQNQlsvglaacvYLWSATTSQVIKLCDL-------GQTNEQDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKK 472
Cdd:cd00200    15 VAFSPDGK---------LLATGSGDGTIKVWDLetgellrTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 473 TRELTGHSSRVGCLAWNADT--ICSGSRDRTIMHRDIRcdDNDMGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWN 550
Cdd:cd00200    86 VRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVE--TGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 551 LRRNEPIQTYTQHNAAVKALAWSPHHHGLLVSGGgtaDRCLRFWNTLTAqpmQCVDT----GSQVCNVAWSKHSSELVSt 626
Cdd:cd00200   164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS---DGTIKLWDLSTG---KCLGTlrghENGVNSVAFSPDGYLLAS- 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2077860273 627 hgYSFNHLqVIIWKYPSLQPVTKLVGHQYRVLYLAMSPDGESIVTGAGDETLRFW 681
Cdd:cd00200   237 --GSEDGT-IRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
416-683 1.25e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.00  E-value: 1.25e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 416 VYLWSATTSQVIKLcdlgQTNEQDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKKTRELTGHSSRVGCLAWNAD--TI 493
Cdd:COG2319   144 VRLWDLATGKLLRT----LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkLL 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 494 CSGSRDRTIMHRDIrcDDNDMGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQHNAAVKALAWS 573
Cdd:COG2319   220 ASGSADGTVRLWDL--ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 574 PHHHgLLVSGGgtADRCLRFWNTLTAQPMQCVD-TGSQVCNVAWSKHSSELVSThgySFNHlQVIIWKYPSLQPVTKLVG 652
Cdd:COG2319   298 PDGK-LLASGS--DDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASG---SDDG-TVRLWDLATGELLRTLTG 370

                         250       260       270
                  ....*....|....*....|....*....|.
gi 2077860273 653 HQYRVLYLAMSPDGESIVTGAGDETLRFWHV 683
Cdd:COG2319   371 HTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 439-683 3.25e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.10  E-value: 3.25e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 439 DQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKKTRELTGHSSRVGCLAWNADT--ICSGSRDRTimhrdIRC---DDND 513
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGtyLASGSSDKT-----IRLwdlETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 514 MGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQHNAAVKALAWSPhhHGLLVSGGGtADRCLRF 593
Cdd:cd00200    85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP--DGTFVASSS-QDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 594 WNTLTAQPMQcVDTG--SQVCNVAWSKHSSELVSThgySFNHlQVIIWKYPSLQPVTKLVGHQYRVLYLAMSPDGESIVT 671
Cdd:cd00200   162 WDLRTGKCVA-TLTGhtGEVNSVAFSPDGEKLLSS---SSDG-TIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLAS 236

                         250
                  ....*....|..
gi 2077860273 672 GAGDETLRFWHV 683
Cdd:cd00200   237 GSEDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 473-681 1.45e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.48  E-value: 1.45e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 473 TRELTGHSSRVGCLAWNAD--TICSGSRDRTImhRDIRCDDNDMGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWN 550
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDgkLLATGSGDGTI--KVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 551 LRRNEPIQTYTQHNAAVKALAWSPHHHgLLVSGGgtADRCLRFWNTLTAQPMQCVDT-GSQVCNVAWSkHSSELVSthGY 629
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSS--RDKTIKVWDVETGKCLTTLRGhTDWVNSVAFS-PDGTFVA--SS 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2077860273 630 SFNHlQVIIWKYPSLQPVTKLVGHQYRVLYLAMSPDGESIVTGAGDETLRFW 681
Cdd:cd00200   154 SQDG-TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
407-683 2.28e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 2.28e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 407 QLSVGLAACVYLWSATTSQVIKLCDLGQTNEQDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKKTRELTGHSSRVGCL 486
Cdd:COG2319     5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 487 AWNAD--TICSGSRDRTImhRDIRCDDNDMGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQHN 564
Cdd:COG2319    85 AFSPDgrLLASASADGTV--RLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 565 AAVKALAWSPHHHgLLVSGGGtaDRCLRFWNTLTAQPMQCVD-TGSQVCNVAWSKHSSELVSTHGYSfnhlQVIIWKYPS 643
Cdd:COG2319   163 GAVTSVAFSPDGK-LLASGSD--DGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADG----TVRLWDLAT 235

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 2077860273 644 LQPVTKLVGHQYRVLYLAMSPDGESIVTGAGDETLRFWHV 683
Cdd:COG2319   236 GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275
WD40 COG2319
WD40 repeat [General function prediction only];
400-596 7.36e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.49  E-value: 7.36e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 400 VDWSSQNQLsvgLAAC-----VYLWSATTSQVIKLcdlgQTNEQDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKKTR 474
Cdd:COG2319   210 VAFSPDGKL---LASGsadgtVRLWDLATGKLLRT----LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 475 ELTGHSSRVGCLAWNAD--TICSGSRDRTIMHRDIrcDDNDMGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWNLR 552
Cdd:COG2319   283 TLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2077860273 553 RNEPIQTYTQHNAAVKALAWSPHHHgLLVSGGgtADRCLRFWNT 596
Cdd:COG2319   361 TGELLRTLTGHTGAVTSVAFSPDGR-TLASGS--ADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 400-595 6.62e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.97  E-value: 6.62e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 400 VDWSSQNQL--SVGLAACVYLWSATTSQVIKLCDlGQTneqDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKKTRELT 477
Cdd:cd00200    99 VAFSPDGRIlsSSSRDKTIKVWDVETGKCLTTLR-GHT---DWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 478 GHSSRVGCLAWNAD--TICSGSRDRTIMHRDIRCDDNDMGrkLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWNLRRNE 555
Cdd:cd00200   175 GHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGT--LRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2077860273 556 PIQTYTQHNAAVKALAWSPhHHGLLVSGGgtADRCLRFWN 595
Cdd:cd00200   253 CVQTLSGHTNSVTSLAWSP-DGKRLASGS--ADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
400-552 3.13e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.60  E-value: 3.13e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 400 VDWSSQNQL--SVGLAACVYLWSATTSQVIKLcdlgQTNEQDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKKTRELT 477
Cdd:COG2319   252 VAFSPDGRLlaSGSADGTVRLWDLATGELLRT----LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 327

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2077860273 478 GHSSRVGCLAWNAD--TICSGSRDRTIMHRDIrcDDNDMGRKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWNLR 552
Cdd:COG2319   328 GHTGAVRSVAFSPDgkTLASGSDDGTVRLWDL--ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 556-683 1.31e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.06  E-value: 1.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 556 PIQTYTQHNAAVKALAWSPHHHgLLVSGGGtaDRCLRFWNTLTAQPMQCvDTG--SQVCNVAWSKHSSELVSThgySFNH 633
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGK-LLATGSG--DGTIKVWDLETGELLRT-LKGhtGPVRDVAASADGTYLASG---SSDK 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2077860273 634 lQVIIWKYPSLQPVTKLVGHQYRVLYLAMSPDGESIVTGAGDETLRFWHV 683
Cdd:cd00200    74 -TIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV 122
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 522-681 1.55e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.63  E-value: 1.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 522 RQEVCGLKW-SPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQHNAAVKALAWSPHHHGLLVSggGTADRCLRFWNTLTAQ 600
Cdd:PLN00181  532 RSKLSGICWnSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLAS--GSDDGSVKLWSINQGV 609

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 601 PMQCVDTGSQVCNVAWSKHSSELVStHGYSFNHLQVIIWKYPSLqPVTKLVGHQYRVLYLAMSpDGESIVTGAGDETLRF 680
Cdd:PLN00181  610 SIGTIKTKANICCVQFPSESGRSLA-FGSADHKVYYYDLRNPKL-PLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKL 686


                  .
gi 2077860273 681 W 681
Cdd:PLN00181  687 W 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 516-550 1.90e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.90e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2077860273  516 RKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWN 550
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 444-573 1.82e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 43.81  E-value: 1.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 444 VQWCDKGDLLAVGTSRGvtQIWdvttqkkTRELTGHssRVgclaWnadticsgsrdrtimhrdircddndmGRKLTNHRQ 523
Cdd:pfam12894   1 MSWCPTMDLIALATEDG--ELL-------LHRLNWQ--RV----W--------------------------TLSPDKEDL 39

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2077860273 524 EVCGLKWSPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQHNAAVKALAWS 573
Cdd:pfam12894  40 EVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 555-595 2.72e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.72e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2077860273  555 EPIQTYTQHNAAVKALAWSPHHHgLLVSGGgtADRCLRFWN 595
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGK-YLASGS--DDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
516-550 2.90e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 2.90e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2077860273 516 RKLTNHRQEVCGLKWSPDKQLLASGGNDNQLLVWN 550
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 643-682 5.06e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 5.06e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2077860273  643 SLQPVTKLVGHQYRVLYLAMSPDGESIVTGAGDETLRFWH 682
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
645-681 2.13e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.13e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 2077860273 645 QPVTKLVGHQYRVLYLAMSPDGESIVTGAGDETLRFW 681
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
554-595 4.04e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 4.04e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2077860273 554 NEPIQTYTQHNAAVKALAWSPHHHgLLVSGGgtADRCLRFWN 595
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK-LLASGS--DDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 469-502 6.27e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 6.27e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2077860273  469 TQKKTRELTGHSSRVGCLAWNAD--TICSGSRDRTI 502
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDgkYLASGSDDGTI 36
WD40 pfam00400
WD domain, G-beta repeat;
471-503 1.30e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.30e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2077860273 471 KKTRELTGHSSRVGCLAWNAD--TICSGSRDRTIM 503
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDgkLLASGSDDGTVK 36
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 428-489 2.90e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 2.90e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2077860273 428 KLCDLGQTNEQDQVTSVQWCDKGDLLAVGTSRGVTQIWDVTTQKKTRELTGHSSRVGCLAWN 489
Cdd:pfam12894  28 RVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 528-619 4.05e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 4.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2077860273 528 LKWSPDKQLLASGGNDNQLLVWNLRRNEPIQTYTQ-HNAAVKALAWSPHHHGLLVsggGTADRCLRFWNTLTAQPMQCVD 606
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDkEDLEVTSLAWRPDGKLLAV---GYSDGTVRLLDAENGKIVHHFS 77

                          90
                  ....*....|....
gi 2077860273 607 TGS-QVCNVAWSKH 619
Cdd:pfam12894  78 AGSdLITCLGWGEN 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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