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Conserved domains on  [gi|2123784228|ref|NP_001383564|]
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p21-activated protein kinase-interacting protein 1-like isoform 2 [Gallus gallus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
5-209 4.70e-32

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.71  E-value: 4.70e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228   5 VEHGALLQ----HNGTITCLEFY--GTaHLLSGAEDGLICIWNTKRWECLKSIKAHKGHVTSLSIHPSGKLALSVGTDKT 78
Cdd:COG2319   191 LATGKLLRtltgHTGAVRSVAFSpdGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228  79 LRTWNLVEGRsaFIKNLKQNAHIIK---WSPDGEkyvTVIT----NKVDIYKLDTASITGTITIEK-RISSIRFITD-SV 149
Cdd:COG2319   270 VRLWDLATGE--LLRTLTGHSGGVNsvaFSPDGK---LLASgsddGTVRLWDLATGKLLRTLTGHTgAVRSVAFSPDgKT 344

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228 150 LAIAGDDEIIRFYSCDSQKCLCEFKAHENRIKDIySFEREGQHvIVTASSDGYIKVWNLD 209
Cdd:COG2319   345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV-AFSPDGRT-LASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
5-209 4.70e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.71  E-value: 4.70e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228   5 VEHGALLQ----HNGTITCLEFY--GTaHLLSGAEDGLICIWNTKRWECLKSIKAHKGHVTSLSIHPSGKLALSVGTDKT 78
Cdd:COG2319   191 LATGKLLRtltgHTGAVRSVAFSpdGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228  79 LRTWNLVEGRsaFIKNLKQNAHIIK---WSPDGEkyvTVIT----NKVDIYKLDTASITGTITIEK-RISSIRFITD-SV 149
Cdd:COG2319   270 VRLWDLATGE--LLRTLTGHSGGVNsvaFSPDGK---LLASgsddGTVRLWDLATGKLLRTLTGHTgAVRSVAFSPDgKT 344

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228 150 LAIAGDDEIIRFYSCDSQKCLCEFKAHENRIKDIySFEREGQHvIVTASSDGYIKVWNLD 209
Cdd:COG2319   345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV-AFSPDGRT-LASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-207 3.14e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.21  E-value: 3.14e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228   2 RKKVEHGALLQHNGTITCLEFYGTAHLLSGA-EDGLICIWNTKRWECLKSIKAHKGHVTSLSIHPSGKLALSVGTDKTLR 80
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228  81 TWNLVEGRsaFIKNLKqnAHI-----IKWSPDGEKYVTVITNK-VDIYKLDTASITGTITI-EKRISSIRFITDSVLAIA 153
Cdd:cd00200   161 LWDLRTGK--CVATLT--GHTgevnsVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLAS 236

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2123784228 154 GD-DEIIRFYSCDSQKCLCEFKAHENRIKDIySFEREGQhVIVTASSDGYIKVWN 207
Cdd:cd00200   237 GSeDGTIRVWDLRTGECVQTLSGHTNSVTSL-AWSPDGK-RLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 45-83 8.28e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 8.28e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2123784228   45 WECLKSIKAHKGHVTSLSIHPSGKLALSVGTDKTLRTWN 83
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
45-83 1.34e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 1.34e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2123784228  45 WECLKSIKAHKGHVTSLSIHPSGKLALSVGTDKTLRTWN 83
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 19-203 2.47e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.93  E-value: 2.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228  19 CLEFYGTAHLLSGAEDGLICIWNTKRWECLKSIKAHKGHVTSLSIHPSGKLALSVGTDK-TLRTWNLVEGRSAFIKNLKQ 97
Cdd:PLN00181  539 CWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDgSVKLWSINQGVSIGTIKTKA 618

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228  98 NAHIIKWSPDGEKYVTVIT--NKVDIYKLDTASITGTITI--EKRISSIRFITDSVLAIAGDDEIIRFY------SCDSQ 167
Cdd:PLN00181  619 NICCVQFPSESGRSLAFGSadHKVYYYDLRNPKLPLCTMIghSKTVSYVRFVDSSTLVSSSTDNTLKLWdlsmsiSGINE 698

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2123784228 168 KCLCEFKAHENrIKDIYSFeregqhvivtASSDGYI 203
Cdd:PLN00181  699 TPLHSFMGHTN-VKNFVGL----------SVSDGYI 723
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
5-209 4.70e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.71  E-value: 4.70e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228   5 VEHGALLQ----HNGTITCLEFY--GTaHLLSGAEDGLICIWNTKRWECLKSIKAHKGHVTSLSIHPSGKLALSVGTDKT 78
Cdd:COG2319   191 LATGKLLRtltgHTGAVRSVAFSpdGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228  79 LRTWNLVEGRsaFIKNLKQNAHIIK---WSPDGEkyvTVIT----NKVDIYKLDTASITGTITIEK-RISSIRFITD-SV 149
Cdd:COG2319   270 VRLWDLATGE--LLRTLTGHSGGVNsvaFSPDGK---LLASgsddGTVRLWDLATGKLLRTLTGHTgAVRSVAFSPDgKT 344

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228 150 LAIAGDDEIIRFYSCDSQKCLCEFKAHENRIKDIySFEREGQHvIVTASSDGYIKVWNLD 209
Cdd:COG2319   345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV-AFSPDGRT-LASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-207 3.14e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.21  E-value: 3.14e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228   2 RKKVEHGALLQHNGTITCLEFYGTAHLLSGA-EDGLICIWNTKRWECLKSIKAHKGHVTSLSIHPSGKLALSVGTDKTLR 80
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228  81 TWNLVEGRsaFIKNLKqnAHI-----IKWSPDGEKYVTVITNK-VDIYKLDTASITGTITI-EKRISSIRFITDSVLAIA 153
Cdd:cd00200   161 LWDLRTGK--CVATLT--GHTgevnsVAFSPDGEKLLSSSSDGtIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLAS 236

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2123784228 154 GD-DEIIRFYSCDSQKCLCEFKAHENRIKDIySFEREGQhVIVTASSDGYIKVWN 207
Cdd:cd00200   237 GSeDGTIRVWDLRTGECVQTLSGHTNSVTSL-AWSPDGK-RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
9-209 5.91e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 117.32  E-value: 5.91e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228   9 ALLQHNGTITCLEF-YGTAHLLSGAEDGLICIWNTKRWECLKSIKAHKGHVTSLSIHPSGKLALSVGTDKTLRTWNLVEG 87
Cdd:COG2319    73 TLLGHTAAVLSVAFsPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228  88 RsaFIKNLKQNAHIIK---WSPDGEKYVTV-ITNKVDIYKLDTASITGTITI-EKRISSIRFITDS-VLAIAGDDEIIRF 161
Cdd:COG2319   153 K--LLRTLTGHSGAVTsvaFSPDGKLLASGsDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGkLLASGSADGTVRL 230

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2123784228 162 YSCDSQKCLCEFKAHENRIKDIySFEREGQHvIVTASSDGYIKVWNLD 209
Cdd:COG2319   231 WDLATGKLLRTLTGHSGSVRSV-AFSPDGRL-LASGSADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
6-212 9.82e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 9.82e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228   6 EHGALLQHNGTITCLEFY--GTaHLLSGAEDGLICIWNTKRWECLKSIKAHKGHVTSLSIHPSGKLALSVGTDKTLRTWN 83
Cdd:COG2319   112 LLRTLTGHTGAVRSVAFSpdGK-TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228  84 LVEGRsaFIKNLKQNAHIIK---WSPDGEKYVTVITNK-VDIYKLDTASITGTITI-EKRISSIRFITD-SVLAIAGDDE 157
Cdd:COG2319   191 LATGK--LLRTLTGHTGAVRsvaFSPDGKLLASGSADGtVRLWDLATGKLLRTLTGhSGSVRSVAFSPDgRLLASGSADG 268

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2123784228 158 IIRFYSCDSQKCLCEFKAHENRIKDIySFEREGQHvIVTASSDGYIKVWNLDLNK 212
Cdd:COG2319   269 TVRLWDLATGELLRTLTGHSGGVNSV-AFSPDGKL-LASGSDDGTVRLWDLATGK 321
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-209 2.24e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.41  E-value: 2.24e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228  13 HNGTITCLEFYGTAH-LLSGAEDGLICIWNTKRWECLKSIKAHKGHVTSLSIHPSGKLALSVGTDKTLRTWNLVEGRsaF 91
Cdd:cd00200    50 HTGPVRDVAASADGTyLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK--C 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228  92 IKNLKqnAHI-----IKWSPDGeKYVTVIT--NKVDIYKLDTASITGTITI-EKRISSIRFITD-SVLAIAGDDEIIRFY 162
Cdd:cd00200   128 LTTLR--GHTdwvnsVAFSPDG-TFVASSSqdGTIKLWDLRTGKCVATLTGhTGEVNSVAFSPDgEKLLSSSSDGTIKLW 204

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 2123784228 163 SCDSQKCLCEFKAHENRIKDIySFEREGqHVIVTASSDGYIKVWNLD 209
Cdd:cd00200   205 DLSTGKCLGTLRGHENGVNSV-AFSPDG-YLLASGSEDGTIRVWDLR 249
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-209 3.03e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.64  E-value: 3.03e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228   6 EHGALLQHNGTITCLEF-YGTAHLLSGAEDGLICIWNTKRWECLKSIKAHKGHVTSLSIHPSGKLALSVGTDKTLRTWNL 84
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFsPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228  85 VEGRSAFIknlkQNAHI-----IKWSPDGeKYVTVIT--NKVDIYKLDTASITGTIT-IEKRISSIRFITDS-VLAIAGD 155
Cdd:cd00200    81 ETGECVRT----LTGHTsyvssVAFSPDG-RILSSSSrdKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGtFVASSSQ 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2123784228 156 DEIIRFYSCDSQKCLCEFKAHENRIKDIySFEREGQHvIVTASSDGYIKVWNLD 209
Cdd:cd00200   156 DGTIKLWDLRTGKCVATLTGHTGEVNSV-AFSPDGEK-LLSSSSDGTIKLWDLS 207
WD40 COG2319
WD40 repeat [General function prediction only];
5-209 6.01e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.98  E-value: 6.01e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228   5 VEHGALLQHNGTITCLEFYGTAHLLSGAEDGLICIWNTKRWECLKSIKAHKGHVTSLSIHPSGKLALSVGTDKTLRTWNL 84
Cdd:COG2319    28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228  85 VEGRS-AFIKNLKQNAHIIKWSPDGEKYVTVITNK-VDIYKLDTASITGTIT-IEKRISSIRFITDS-VLAIAGDDEIIR 160
Cdd:COG2319   108 ATGLLlRTLTGHTGAVRSVAFSPDGKTLASGSADGtVRLWDLATGKLLRTLTgHSGAVTSVAFSPDGkLLASGSDDGTVR 187

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2123784228 161 FYSCDSQKCLCEFKAHENRIKDIySFEREGQHvIVTASSDGYIKVWNLD 209
Cdd:COG2319   188 LWDLATGKLLRTLTGHTGAVRSV-AFSPDGKL-LASGSADGTVRLWDLA 234
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-212 2.87e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.15  E-value: 2.87e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228  47 CLKSIKAHKGHVTSLSIHPSGKLALSVGTDKTLRTWNLVEGRsaFIKNLKQNAHIIKW---SPDGEKYVTVITNK-VDIY 122
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDvaaSADGTYLASGSSDKtIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228 123 KLDTASITGTIT-IEKRISSIRFITD-SVLAIAGDDEIIRFYSCDSQKCLCEFKAHENRIKDIySFEREGQhVIVTASSD 200
Cdd:cd00200    79 DLETGECVRTLTgHTSYVSSVAFSPDgRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSV-AFSPDGT-FVASSSQD 156

                         170
                  ....*....|..
gi 2123784228 201 GYIKVWNLDLNK 212
Cdd:cd00200   157 GTIKLWDLRTGK 168
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-83 1.03e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.06  E-value: 1.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228   1 MRKKVEHGALLQHNGTITCLEFYGTAHLL-SGAEDGLICIWNTKRWECLKSIKAHKGHVTSLSIHPSGKLALSVGTDKTL 79
Cdd:cd00200   206 LSTGKCLGTLRGHENGVNSVAFSPDGYLLaSGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285


                  ....
gi 2123784228  80 RTWN 83
Cdd:cd00200   286 RIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 45-83 8.28e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 8.28e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2123784228   45 WECLKSIKAHKGHVTSLSIHPSGKLALSVGTDKTLRTWN 83
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
45-83 1.34e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 1.34e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2123784228  45 WECLKSIKAHKGHVTSLSIHPSGKLALSVGTDKTLRTWN 83
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 19-203 2.47e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.93  E-value: 2.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228  19 CLEFYGTAHLLSGAEDGLICIWNTKRWECLKSIKAHKGHVTSLSIHPSGKLALSVGTDK-TLRTWNLVEGRSAFIKNLKQ 97
Cdd:PLN00181  539 CWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDgSVKLWSINQGVSIGTIKTKA 618

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228  98 NAHIIKWSPDGEKYVTVIT--NKVDIYKLDTASITGTITI--EKRISSIRFITDSVLAIAGDDEIIRFY------SCDSQ 167
Cdd:PLN00181  619 NICCVQFPSESGRSLAFGSadHKVYYYDLRNPKLPLCTMIghSKTVSYVRFVDSSTLVSSSTDNTLKLWdlsmsiSGINE 698

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2123784228 168 KCLCEFKAHENrIKDIYSFeregqhvivtASSDGYI 203
Cdd:PLN00181  699 TPLHSFMGHTN-VKNFVGL----------SVSDGYI 723
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 136-213 7.65e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 7.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228 136 EKRISSIRFITDS-VLAIAGDDEIIRFYSCDSQKCLCEFKAHENRIKDI--YSFeregQHVIVTASSDGYIKVWNLDLNK 212
Cdd:cd00200     9 TGGVTCVAFSPDGkLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVaaSAD----GTYLASGSSDKTIRLWDLETGE 84


                  .
gi 2123784228 213 I 213
Cdd:cd00200    85 C 85
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 166-207 1.83e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 1.83e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2123784228  166 SQKCLCEFKAHENRIKDIySFEREGQHvIVTASSDGYIKVWN 207
Cdd:smart00320   1 SGELLKTLKGHTGPVTSV-AFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
168-207 1.72e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 1.72e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2123784228 168 KCLCEFKAHENRIKDIySFEREGQHvIVTASSDGYIKVWN 207
Cdd:pfam00400   2 KLLKTLEGHTGSVTSL-AFSPDGKL-LASGSDDGTVKVWD 39
8prop_heme_binding_protein cd20718
eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; ...
 23-137 2.18e-03

eight-bladed beta-propeller heme-binding domain in cytochrome cd1 and similar proteins; Members here contain an 8-bladed beta-propeller heme-binding domain in cytochrome cd1 (nitrite reductase) and similar proteins including NirN and NirF. During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO(3-)-> NO(2-)-> NO -> N2O -> N2. The integral membrane proteins NorC, NorB, and NosR form the core assembly platform that binds the nitrate reductase NarGHI and the periplasmic nitrite reductase NirS via its maturation factor NirF. NirN and NirF form a stable complex with the nitrite reductase NirS during enzyme maturation. NirF is involved in heme d1 insertion.


Pssm-ID: 467720 [Multi-domain]  Cd Length: 380  Bit Score: 39.24  E-value: 2.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123784228  23 YGTAHLLSGA-------------EDGLICIWNTKRWECLKSIKAhKGHVTSLSIHPSGKLalsVGTDKTLRTWN-----L 84
Cdd:cd20718   237 GKTPHPGPGAtwgrkgvtatphlGEGIVTVWDLDTWKPVKYIPT-PGPGRFVRTHPSSPY---VWADTVFGPENadeiyV 312

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2123784228  85 VEGRS----AFIKNLKQN-AHIIKWSPDGeKYVTVI---TNKVDIYKLDTASITGTITIEK 137
Cdd:cd20718   313 IDKETlkvvKTLIPKPGKrALHPEFTRDG-KYVYVSvwdGGEVVVYDAETLELVKRIPAET 372
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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