NCBI Conserved Domain Search

Conserved domains on [gi|2128271410|ref|NP_001384012|]

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voltage-dependent calcium channel gamma-3 subunit [Gallus gallus]

Protein Classification

PMP-22/EMP/MP20 family protein( domain architecture ID 10467089)

PMP-22/EMP/MP20 family tetraspan membrane protein similar to human claudin-9 (hCLDN-9) which is highly expressed in the inner ear, essential for hearing and a high-affinity receptor of CpE

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

PMP22_Claudin

pfam00822

PMP-22/EMP/MP20/Claudin family;

6-196

2.38e-44

PMP-22/EMP/MP20/Claudin family;

Pssm-ID: 395662 Cd Length: 162 Bit Score: 149.06 E-value: 2.38e-44

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128271410   6 RGVQMLITTVGAFAAFSLMTIAVGTDYWLYSRGVCrtksggdndtsrkneeVMTHSGLWRTCCLEG-TFRGVCKKidhfP 84
Cdd:pfam00822   1 MLVLLLGFIVSHIAWVILLFVATIPDQWKVSRYVG----------------AAASAGLWRNCTTQScTGQISCKV----L 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128271410  85 EDADYEQDTAEYLLRAVrassIFPILSVGLLFFGGLCVAASEFYKskhnvilSAGIFFVSAGLSNIIGIIVYISANAGDP 164
Cdd:pfam00822  61 ELNDALQAVQALMILSI----ILGIISLIVFFFQLFTMRKGGRFK-------LAGIIFLVSGLCVLVGASIYTSRIATDF 129

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2128271410 165 GQSDSKK-SYSYGWSFYFGALSFIIAEMVGVIA 196
Cdd:pfam00822 130 GNPFTPNrKYSFGYSFILGWVAFALAFIGGVLY 162

Name

Accession

Description

Interval

E-value

PMP22_Claudin

pfam00822

PMP-22/EMP/MP20/Claudin family;

6-196

2.38e-44

PMP-22/EMP/MP20/Claudin family;

Pssm-ID: 395662 Cd Length: 162 Bit Score: 149.06 E-value: 2.38e-44

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128271410   6 RGVQMLITTVGAFAAFSLMTIAVGTDYWLYSRGVCrtksggdndtsrkneeVMTHSGLWRTCCLEG-TFRGVCKKidhfP 84
Cdd:pfam00822   1 MLVLLLGFIVSHIAWVILLFVATIPDQWKVSRYVG----------------AAASAGLWRNCTTQScTGQISCKV----L 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128271410  85 EDADYEQDTAEYLLRAVrassIFPILSVGLLFFGGLCVAASEFYKskhnvilSAGIFFVSAGLSNIIGIIVYISANAGDP 164
Cdd:pfam00822  61 ELNDALQAVQALMILSI----ILGIISLIVFFFQLFTMRKGGRFK-------LAGIIFLVSGLCVLVGASIYTSRIATDF 129

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2128271410 165 GQSDSKK-SYSYGWSFYFGALSFIIAEMVGVIA 196
Cdd:pfam00822 130 GNPFTPNrKYSFGYSFILGWVAFALAFIGGVLY 162

Name

Accession

Description

Interval

E-value

PMP22_Claudin

pfam00822

PMP-22/EMP/MP20/Claudin family;

6-196

2.38e-44

PMP-22/EMP/MP20/Claudin family;

Pssm-ID: 395662 Cd Length: 162 Bit Score: 149.06 E-value: 2.38e-44

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128271410   6 RGVQMLITTVGAFAAFSLMTIAVGTDYWLYSRGVCrtksggdndtsrkneeVMTHSGLWRTCCLEG-TFRGVCKKidhfP 84
Cdd:pfam00822   1 MLVLLLGFIVSHIAWVILLFVATIPDQWKVSRYVG----------------AAASAGLWRNCTTQScTGQISCKV----L 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128271410  85 EDADYEQDTAEYLLRAVrassIFPILSVGLLFFGGLCVAASEFYKskhnvilSAGIFFVSAGLSNIIGIIVYISANAGDP 164
Cdd:pfam00822  61 ELNDALQAVQALMILSI----ILGIISLIVFFFQLFTMRKGGRFK-------LAGIIFLVSGLCVLVGASIYTSRIATDF 129

                         170       180       190
                  ....*....|....*....|....*....|...
gi 2128271410 165 GQSDSKK-SYSYGWSFYFGALSFIIAEMVGVIA 196
Cdd:pfam00822 130 GNPFTPNrKYSFGYSFILGWVAFALAFIGGVLY 162

Claudin_2

pfam13903

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight ...

20-179

1.73e-13

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight junctions between cells.

Pssm-ID: 372799 [Multi-domain] Cd Length: 191 Bit Score: 67.83 E-value: 1.73e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128271410  20 AFSLMTIAVGTDYWLYSrgvcrtkSGGDNDTSRKNEEVmTHSGLWRTC-------------CLEGTFRGVCKKIDHFPED 86
Cdd:pfam13903   3 AFALLLIAFATDYWLVL-------DVALTGINNYTCLF-AHLGLWRHCfksevdvdsdnqtRFFGCLNQVPNPFPTFEEE 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2128271410  87 ADYEQDTAEYLLRavRASSIFPILSVGLLFFGGLCVAASeFYKSKHNVILSAGIFFVSAGLSNIIGIIVYI--------- 157
Cdd:pfam13903  75 IVSFSVTSLPGLT--RFVQAFAILSLVLIVCGVVCGLLA-LPKQSVFLLLAAGILFLLSGVLGLLGVIVFGqsvklvfee 151

                         170       180
                  ....*....|....*....|..
gi 2128271410 158 SANAGDPGQSDSKKsYSYGWSF 179
Cdd:pfam13903 152 YFRQWMPEHQNNVR-ISFGWSF 172

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01