NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2170955333|ref|NP_001385873|]
View 

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 [Rattus norvegicus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 690)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.99.-
Gene Ontology:  GO:0008373|GO:0006486
PubMed:  9334165

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 105-332 1.04e-172

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467706  Cd Length: 229  Bit Score: 478.20  E-value: 1.04e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 105 CNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSSVFRVLRKPQEFVNRTPETVFIFWG 184
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 185 PPNKMQKPQGSLL-RVIQRAGLAFPNMEAYAVSQARMQQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 263
Cdd:cd23978    81 PPNKMQKDGKSNLfRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2170955333 264 MVPPDYCSQRPRLQRMPYHYYEPKGPDECVTYIQNEHSRKGNHHRFITEKRVFSSWAQLYGITFSHPSW 332
Cdd:cd23978   161 MVPPNYCSKRPTPKKMPYHYYEPKGPDECVTYIQNEHGRRGNHHRFITEKRVFARWAEHYNITFSHPSW 229
 
Name Accession Description Interval E-value
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 105-332 1.04e-172

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 478.20  E-value: 1.04e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 105 CNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSSVFRVLRKPQEFVNRTPETVFIFWG 184
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 185 PPNKMQKPQGSLL-RVIQRAGLAFPNMEAYAVSQARMQQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 263
Cdd:cd23978    81 PPNKMQKDGKSNLfRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2170955333 264 MVPPDYCSQRPRLQRMPYHYYEPKGPDECVTYIQNEHSRKGNHHRFITEKRVFSSWAQLYGITFSHPSW 332
Cdd:cd23978   161 MVPPNYCSKRPTPKKMPYHYYEPKGPDECVTYIQNEHGRRGNHHRFITEKRVFARWAEHYNITFSHPSW 229
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 102-285 3.76e-25

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 101.53  E-value: 3.76e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 102 PSRCNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVV-AHSSVFRVLRKPQEFVNRTPETVF 180
Cdd:pfam00777  40 NKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMnPESAIDSKYGNLGFSHPRDPFVEF 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 181 IFwgPPNKMQkpqgSLL---RVIQRAGLAFPNMEAYAVSQARMQQFDDLFR-------GETGKDREKSHSW----LSTGW 246
Cdd:pfam00777 120 VL--VPFKGR----DLLwlpAFLTKGNVSRSLRVLYTLKEVKIPVDPDKVLflhpdflRYVANFWLRSHGLkgrrPSTGL 193

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2170955333 247 FTMVIAVELCDHVHVYGMVPPDYcsqrprLQRMPYHYYE 285
Cdd:pfam00777 194 LMLSLALHLCDEVSLYGFGPFLD------SRGNSHHYYD 226
 
Name Accession Description Interval E-value
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 105-332 1.04e-172

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 478.20  E-value: 1.04e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 105 CNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSSVFRVLRKPQEFVNRTPETVFIFWG 184
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 185 PPNKMQKPQGSLL-RVIQRAGLAFPNMEAYAVSQARMQQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 263
Cdd:cd23978    81 PPNKMQKDGKSNLfRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2170955333 264 MVPPDYCSQRPRLQRMPYHYYEPKGPDECVTYIQNEHSRKGNHHRFITEKRVFSSWAQLYGITFSHPSW 332
Cdd:cd23978   161 MVPPNYCSKRPTPKKMPYHYYEPKGPDECVTYIQNEHGRRGNHHRFITEKRVFARWAEHYNITFSHPSW 229
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 105-330 1.09e-124

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 356.55  E-value: 1.09e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 105 CNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSSVFRVLRKP-QEFVNRTPETVFIFW 183
Cdd:cd23965     1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRNAiLLLAGTRAPTVVVFW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 184 GPPNKMQKPQGSLLRVIQRAGLAFPNMEAYAVSQARMQQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 263
Cdd:cd23965    81 GPETKMNKDGAGKYNLLRSLSKKYPDVEFYSLTPEKMDYADELFEKETGKSRIKSGTWLSTGWFTMLLALDVCDEIKVYG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2170955333 264 MVPPDYCSQRPRlQRMPYHYYEPKGPDECVTYIQNEHSRKGnHHRFITEKRVFSSWAQLYGITFSHP 330
Cdd:cd23965   161 MVPENYCREHPN-SKVPYHYYEPGGLKECTYYNYHENALKG-GHRFITEKAVFARWAKKYNITFHHP 225
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 92-332 2.23e-108

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 316.04  E-value: 2.23e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333  92 YFPILGNKTLPSRCNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSSVFRVLRKPQEF 171
Cdd:cd23976     2 YISIIDHKPLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNEL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 172 VNRTPETVFIFWGPPNKMQKP-QGSLLRVIQRAGLAFPNMEAYAVSQARMQQFDDLFRGETGKDREKSHSWLSTGWFTMV 250
Cdd:cd23976    82 LNVSQGTVFIFWGPSNYMRRDgKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFTMI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 251 IAVELCDHVHVYGMVPPDYCsQRPRLQRMPYHYYEPKGPDECVTYIQNEHSRKGNHHRFITEKRVFSSWAQLYGITFSHP 330
Cdd:cd23976   162 IALELCDRINVYGMVPPDFC-RDPNHPSVPYHYYEPSGPDECTMYISHERGRKGSHHRFITEKRVFANWARTFNIHFYQP 240


                  ..
gi 2170955333 331 SW 332
Cdd:cd23976   241 DW 242
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 105-333 3.09e-85

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 256.71  E-value: 3.09e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 105 CNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSSVFRVLRKPQEFVNRTPETVFIFWG 184
Cdd:cd23977     1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 185 PPNKM-QKPQGSLLRVIQRAGLAFPNMEAYAVSQARMQQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 263
Cdd:cd23977    81 PERNMdRDGGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYG 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 264 MVPPDYCSQRPRlQRMPYHYYEPKGPDECVTYIQNEHSRKGNhHRFITEKRVFSSWAQLYGITFSHPSWT 333
Cdd:cd23977   161 MVSDSYCRNKNH-SSVPYHYYEKGRLDECRMYLVHERAPRGG-HRFITEKAIFSRWAKRKKIRFAHPSWT 228
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 105-332 8.40e-80

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 242.53  E-value: 8.40e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 105 CNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSSVFRVLRKPQEFVNRTPETVFIFWG 184
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 185 PPNKMQKP-QGSLLRVIQRAGLAFPNMEAYAVSQARMQQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 263
Cdd:cd23975    81 PFRNMRKDgKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2170955333 264 MVPPDYCSQRPrLQRMPYHYYEPkGPDECVTYIQNEHSRKGNhHRFITEKRVFSSWAQLYGITFSHPSW 332
Cdd:cd23975   161 MINDTYCKTEG-YRKVPYHYYEP-GRDECDEYFLHENAPYGG-HRFITEKKVFAKWAKKHPITFTHPNW 226
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 108-319 5.20e-35

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 126.32  E-value: 5.20e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 108 CVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSSVFRVLRKPQEFVNRTP---ETVFIFWG 184
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLPleeEVVLILSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 185 PPNKMQKpqgsllRVIQRAGLafPNMEAYAVS---QARMQQFDDLFRGETGKDrEKSHSWLSTGWFTMVIAVELCDHVHV 261
Cdd:cd19952    81 AAAADFK------RLKRRKKR--HDNAVLLLTdpaPDLLSYVRKRLEKLGLKS-FFGGNAPSSGLLAVLLALQLCDSVDL 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 262 YGM--VPPDYCSQrprlqrmPYHYYEPKGPdecvtyiqnehSRKGNHHRFITEKRVFSSW 319
Cdd:cd19952   152 YGFgvDSGHAPKV-------PYHYYDLVEA-----------EEGTAVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 102-285 3.76e-25

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 101.53  E-value: 3.76e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 102 PSRCNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVV-AHSSVFRVLRKPQEFVNRTPETVF 180
Cdd:pfam00777  40 NKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMnPESAIDSKYGNLGFSHPRDPFVEF 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 181 IFwgPPNKMQkpqgSLL---RVIQRAGLAFPNMEAYAVSQARMQQFDDLFR-------GETGKDREKSHSW----LSTGW 246
Cdd:pfam00777 120 VL--VPFKGR----DLLwlpAFLTKGNVSRSLRVLYTLKEVKIPVDPDKVLflhpdflRYVANFWLRSHGLkgrrPSTGL 193

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 2170955333 247 FTMVIAVELCDHVHVYGMVPPDYcsqrprLQRMPYHYYE 285
Cdd:pfam00777 194 LMLSLALHLCDEVSLYGFGPFLD------SRGNSHHYYD 226
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 104-287 5.23e-24

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 97.36  E-value: 5.23e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 104 RCNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSSVFR-------------VLRKPQE 170
Cdd:cd23967     1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRdpeeydsdwllvlVPFKSMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 171 FV-------NRTPETVFIFWG--------PPNKMQ--KPQgsllrVIQRAGlafpnmeayavsqarmqqfDDLfrGETGK 233
Cdd:cd23967    81 LLwlqavikGKKPNGKGGFWKkiatsvpkPPKKIRilNPY-----ILQEAA-------------------FDL--IGLPM 134

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2170955333 234 DREKSHSWLSTGWFTMVIAVELCDHVHV----YGMVPPDycsqrprlqrMPYHYYEPK 287
Cdd:cd23967   135 NGKQGKNVPTTGIIAIVMALHYCDEVDIagfgYDPSDPN----------APLHYYDSL 182
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 106-312 5.58e-22

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 93.48  E-value: 5.58e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 106 NQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSSVFRVL------RKPQEFVNRTPETV 179
Cdd:cd23963    64 KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSILKRRYnslkknRDRDKFLNRLKEYN 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 180 -FIFWGPPNKMQKPQGSLLRVIQRAGLAFPNME---AYAVSQARMQQfddlFRGETGKDRekshsWLSTGWFTMVIAVEL 255
Cdd:cd23963   144 gSILWYPKFSFKSSTNLLLKAARALKKNGLNLTvvySNPEHFLAVQK----FWKRRGLEK-----RPSTGLYLVSLALTF 214

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2170955333 256 CDHVHVYGMVPpdYcSQRPRLQRMPYHYYEPkgpdecvtyiqNEHSRKGNHHRFITE 312
Cdd:cd23963   215 CDEIHLYGFWP--F-PTDPNGRPVPYHYYDD-----------LSPSTKNKVHNMPEE 257
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 72-286 9.61e-20

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 86.94  E-value: 9.61e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333  72 SLRGRSRRPVNLKKWSfsnaYFPILGNKTLPSRC-NQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNK 150
Cdd:cd23968    15 STLRKTTSPFKDLLSL----RYPFPESSLENTKRyNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSK 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 151 TTFRVVAH----SSVFRVLRKPqEFVNrtpETVFIfWGP-------PNKMQKPQGSLLRVIQRAGLAFPNMEAYAVSQAR 219
Cdd:cd23968    91 TTLRLINSqilsKPEFNFLTDP-LYRN---VTLLV-WDPssynvnlEKWYKKPDFDFFPNYIKYRRRHPEEPFYLIDPRF 165

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2170955333 220 M-QQFDDLFRGETGKDREKSHswlSTGWFTMVIAVELCDHVHVYGMVPPdycSQRPRLQrmpyHYYEP 286
Cdd:cd23968   166 LwRLWDILQEYTPEKIKPNPP---SSGFIGIVLMLHLCDWVDVYEYVPS---VRQTDRC----HYYDV 223
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 80-285 7.10e-17

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 78.98  E-value: 7.10e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333  80 PVNLKKWSfsnAYFPilgNKTLPSRCNQ---CVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVV 156
Cdd:cd23985    23 PFNTSEWE---GYLP---KKSLREEVGPlgrCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLI 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 157 aHSSVfrVLRKPQEFVNRT--PETVFIFWGP-------PNKMQKPQGSLLRVIQRAGLAFPNMEAYaVSQARMQ-QFDDL 226
Cdd:cd23985    97 -NSQL--VTTEKHKFLKDSlyNEGILIVWDPapyhsdiPEWYKNPDYNFFENYKTYRRLNPNQPFY-ILHPQMQwELWDI 172

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2170955333 227 FRGETGKDREKSHSwlSTGWFTMVIAVELCDHVHVYGMVPpdycSQRprlQRMPYHYYE 285
Cdd:cd23985   173 IQENSPEEIQPNPP--SSGMLGIILMMTLCDQVDVYEFLP----SKR---KTDVCHYYQ 222
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 92-285 1.81e-16

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 77.96  E-value: 1.81e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333  92 YFP-ILGNKTLPSRCNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHssvfRVLRKPQE 170
Cdd:cd23986    35 YVPkIPLSKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINS----QILTNPNH 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 171 FVNRTP---ETVFIFWGPP-------NKMQKPQGSLLRVIQRAGLAFPNMEAYAVSQARMQQFDDLFRGETGKDREKSHS 240
Cdd:cd23986   111 HFIDSSlykDVILVAWDPApysanlhKWYKKPDYNLFTPYVQYRKRNPNQPFYILHPKFIWQLWDIIQENTQEKIQPNPP 190

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 2170955333 241 wlSTGWFTMVIAVELCDHVHVYGMVPP----DYCsqrprlqrmpyHYYE 285
Cdd:cd23986   191 --SSGFIGILIMMSMCREVHVYEYIPSvrqtDLC-----------HYHE 226
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 104-285 2.55e-14

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 70.46  E-value: 2.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 104 RCNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVV----AHSS-----------VFrVLRKP 168
Cdd:cd23982     1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFypesAQFDpgiendpdtllVL-VPFKP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 169 QEF------VNRTPETVFIFWGPPNKMQKPQGSLLRVIqraglafpNMEAYAVSQARMQQFddlfrgeTGKDREKSHSwl 242
Cdd:cd23982    80 LDFywlyeiLSNEKRVRKGFWKQPPRIWDANPKQIRIL--------NPYYTYVAATKLLQV-------PGQRKKKQKP-- 142

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2170955333 243 STGWFTMVIAVELCDHVHVYGMVPPDycsqrPRLQRMPYHYYE 285
Cdd:cd23982   143 TTGLLAITLALHLCDEVHIAGFGYPD-----NGNSNQPIHYYN 180
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 105-285 1.04e-13

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 69.00  E-value: 1.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 105 CNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVV------------AHSSVF-RVLRKPQEF 171
Cdd:cd23983     2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTypegapkseqeyDPTSLFvAVLFKSVDF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 172 ------VNRTPETV---FIFWGPPNKMQKPQGSLLRV-----IQRAGLafpNMEAYAVSQARMQQFDdlfrgetgkdreK 237
Cdd:cd23983    82 awlkamVKKEPLSFwsrLFFWKEVADSIPLKPSQFRIlnpliIKETAL---DILQYPEPQSRLWGWD------------K 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2170955333 238 SHSWLstGWFTMVIAVELCDHVHVYGMvppDYCSQRPRLqrmPYHYYE 285
Cdd:cd23983   147 NVPTL--GVTAVVLATHLCDEVSLAGF---GYDLSQPHA---PLHYYD 186
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 106-288 1.80e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 69.73  E-value: 1.80e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 106 NQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKT---TFR-------------VVAHSSVFRVLRK-- 167
Cdd:cd23970    69 NTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTnltTFNpsilekyynnlltIQDRNNFFLSLKKld 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 168 ------PQEF------VNRTPETVFI-FWGPPNkmqkpqgsllrvIQragLAFP-NMeayavsqarMQQFDDLFRGETGK 233
Cdd:cd23970   149 gailwiPAFFfhtsatVTRTLVDFFVeHRGQLK------------VQ---LAWPgNI---------MQHVNRYWKTKHLS 204

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2170955333 234 DREkshswLSTGWFTMVIAVELCDHVHVYGMVP-PDYCSQRPrlqrMPYHYYEPKG 288
Cdd:cd23970   205 PKR-----LSTGILMYTLASAICEEIHLYGFWPfGFDPTGTP----LPYHYYDKKG 251
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 102-264 1.56e-12

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 66.92  E-value: 1.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 102 PSRCNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAhssvfrvlrkPQEFVNRTPETVFI 181
Cdd:cd23966    74 PNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMY----------PESAVDLDPGVHLV 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 182 ---FwgppnkmqKPQGsllrvIQRAGLAFPNME---AYavsqARMQQFDDLfrgetgkDREK-----------SH-SWL- 242
Cdd:cd23966   144 lvpF--------KVLD-----LQWLISALTTGEitrTY----TPVKRFIKA-------DKDKvlvinpafikyVHdNWTe 199

                         170       180
                  ....*....|....*....|....*...
gi 2170955333 243 ------STGWFTMVIAVELCDHVHVYGM 264
Cdd:cd23966   200 hhgrypSTGFLALIFALHICDEVSVFGF 227
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 104-288 2.44e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 66.28  E-value: 2.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 104 RCNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFrVVAHSSVfrVLRKPQEFVNRTPETVF--- 180
Cdd:cd23969    63 HFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNL-TTMNPSV--IPHAYGDLVNATDKEKFver 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 181 -------IFWGPP---NKMQKPQGSLLRVIQRAGL----AFPNmeayavsqARMQQfddLFRG--ETGKDREKSHswlST 244
Cdd:cd23969   140 lrqlgdsILWIPAfvsKGGEEHVQWTNEIILKHKLnvktAYPP--------LRLNH---AIRGywLTTKFRIKRP---ST 205

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 2170955333 245 GWFTMVIAVELCDHVHVYGMVPpdyCSQRPRLQRMPYHYYEPKG 288
Cdd:cd23969   206 GLLMYTLATRFCDEIHLYGFYP---FSEDGNGRAVKYHYYDNRK 246
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 105-285 5.58e-12

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 64.00  E-value: 5.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 105 CNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSSVFR-------------VLRKPQ-- 169
Cdd:cd23984     2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSdpshydpnttvvlIPFKPHdl 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 170 ----EFVNRTPETVFIFW-GPPNKMQ-KP-QGSLL--RVIQRAG---LAFPnmeayavsqarmQQFDdlfrgetgKDREK 237
Cdd:cd23984    82 rwllDLLMGKKVSAKGFWkKPALNLIyKPnQIRILnpFILRIAAyelLHFP------------KRFP--------KEKKP 141

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2170955333 238 SHSwlSTGWFTMVIAVELCDHVHVYGMvppdycsqRPRLQRM--PYHYYE 285
Cdd:cd23984   142 KHP--TTGIIAITLALHICNEVHIAGF--------KYDFSNLnsTLHYYG 181
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 96-285 4.46e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 62.65  E-value: 4.46e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333  96 LGNKTLPSrcnqCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFrVVAHSSVfrVLRKPQEFVNRT 175
Cdd:cd23987    59 LKNKHFKT----CAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDL-VTMNPSV--VQRAFEDLVNET 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 176 PETVFIfwgppNKMQKPQGSLLRViqraglafPNMEAYAvSQARMQQFDDLFRGETGKDREKSHS----------WL--- 242
Cdd:cd23987   132 WKEKFL-----QRLQSLNGSILWI--------PAFMAKG-GEERVEWVNDLILKHHINVRTAYPSlrllhavrgyWLtnk 197

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2170955333 243 ------STGWFTMVIAVELCDHVHVYGMVP-PDYCSQRPrlqrMPYHYYE 285
Cdd:cd23987   198 vhikrpTTGLLMYTLATRFCNRIHLYGFWPfPRDQNQNP----VKYHYYD 243
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 103-323 9.71e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 61.69  E-value: 9.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 103 SRCNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSSVFRVLRKPQEF----VNRTPET 178
Cdd:cd23973    81 DGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILQKRgfknIPQDKDI 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 179 VFIF---------WGPPNKMQK--PQGSLLRVIQRA--GLAFpNMEAYAVSQarmQQFDDLFRGE--TGKDREKSHSWL- 242
Cdd:cd23973   161 KYILfpegprdyqWLEALLKNKtiPSGAYYGRRPRSyfSGDF-TEDKYLVLH---PDFLRYVKNRflRSKTLKGKYWAIy 236

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 243 --STGWFTMVIAVELCDHVHVYGMVPPDYcsqrprlQRMPYHYYEpKGPDECVTYIqnehsrkgnHHRFITEKRVfssWA 320
Cdd:cd23973   237 rpTTGAFLLLTALHLCDTVSAYGFITEDY-------RKYPDHYYD-KKKTKLVFYI---------NHDFRLEKKL---WK 296


                  ...
gi 2170955333 321 QLY 323
Cdd:cd23973   297 RLH 299
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 102-263 3.71e-10

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 59.89  E-value: 3.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 102 PSRCNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSSvFRVLRKPQEFVNRTPETVFI 181
Cdd:cd23980    78 LVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPES-FRELAQNVSMILVPFKTLDL 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 182 FW-------GPPNKMQKPQGSLLRVIQRAGLAF-PNMEAYAvsqarmqqFDDLFRGEtGKdrekshsWLSTGWFTMVIAV 253
Cdd:cd23980   157 EWvisatttGTISHTYVPVPRKIKVKKEKILIYhPAFIKYV--------FDRWLQGH-GR-------YPSTGILSVIFSL 220

                         170
                  ....*....|
gi 2170955333 254 ELCDHVHVYG 263
Cdd:cd23980   221 HVCDEVDLYG 230
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 75-289 8.09e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 58.81  E-value: 8.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333  75 GRSRRPVNLKKWSFSnaYFP---ILGNKTLpsrcNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTgYSADVGNKT 151
Cdd:cd23971    37 GERKKTITVNEKLFS--MLPkesPFSNKPL----KTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKT 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 152 TFrVVAHSSVFRvlrkpQEFVNrtpetvfifwgpPNKMQKPQGSLLRVIQRAGLAFP------NMEA-----YAVSQARM 220
Cdd:cd23971   110 NL-VTANPSILR-----EKFHN------------LKKRRRPFVERMKVYGNALLLLPafsytsNTEPslralYTLEDFGS 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 221 QQ------------FDDLFRGETGKDREkshswLSTGwFTMV-IAVELCDHVHVYGMVPpdyCSQRPRLQRMPYHYYEPK 287
Cdd:cd23971   172 PQkvlffnpeylrnLSRYWKSKGLKARR-----LSTG-LMLVsAALELCENVHLYGFWP---FSTDLDGNPISHHYYDNV 242


                  ..
gi 2170955333 288 GP 289
Cdd:cd23971   243 LP 244
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 102-263 1.84e-09

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 57.57  E-value: 1.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 102 PSRCNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSSVfRVLRKPQEFVNRTPETVFI 181
Cdd:cd23979    77 PSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESA-KNLPANVSFVLVPFKTLDL 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 182 FWgppnkmqkpQGSLLRVIQRAGLAFPNMEAYAVSQARMQQFDDLFRGETgKDREKSH--SWLSTGWFTMVIAVELCDHV 259
Cdd:cd23979   156 LW---------ITSALSTGQIRFTYAPVKQFLRVDKDKVQIYNPAFFKYI-HDRWTEHhgRYPSTGMLVLFFALHVCDEV 225


                  ....
gi 2170955333 260 HVYG 263
Cdd:cd23979   226 NVYG 229
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 104-285 2.77e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 57.27  E-value: 2.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 104 RCNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSSVFRV---LRKP---QEFVNRTPE 177
Cdd:cd23988    63 RFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAfggFRNEsdrEKFVHRLSM 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 178 --------TVFIFWGPPNKMQKPQGSLLRVIQRAGLAFPNME-AYAVsqarmqqfddlfRGE--TGKDREKSHswlSTGW 246
Cdd:cd23988   143 lndsvlwiPAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLRlIHAV------------RGYwlTNKVNIKRP---STGL 207

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2170955333 247 FTMVIAVELCDHVHVYGMVP-PDYCSQRPrlqrMPYHYYE 285
Cdd:cd23988   208 LMYTLATRFCDEIHLYGFWPfPKDANGNP----VKYHYYD 243
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 104-184 8.57e-09

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 54.93  E-value: 8.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 104 RCNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSSvfrVLRKPQEFvnrTPETVFIFW 183
Cdd:cd23981     1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEG---AIQKPEQY---EKDSLFVLA 74


                  .
gi 2170955333 184 G 184
Cdd:cd23981    75 G 75
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 102-325 1.09e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 55.34  E-value: 1.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 102 PSRCNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSSVFRVLRKPqefVNRTPETVFI 181
Cdd:cd23964    79 RPRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHNSLLKH---VPQDKDTKYL 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 182 F----------------WGPPNKMQKpqgsllrviqrAGLAFPNMEAYAVSQARMQQFD-DLFRgetgkdreksH---SW 241
Cdd:cd23964   156 FipfkirdydyldavlsGKPVPDGCD-----------KGKRPPPLFGPKLNATNVRLLHpDFIR----------YlfnRW 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 242 L--------STGWFTMVIAVELCDHVHVYGM-VPPDYcsqrprlqrmPYHYYEPKgpdecvtyIQNEHSRKGNHHrFITE 312
Cdd:cd23964   215 LnsstsyrpTTGALMLLTALHTCDQVSVYGFgYDPRF----------SLHYYDKT--------FVKFTVFYANHD-FTNE 275

                         250
                  ....*....|....*
gi 2170955333 313 KRVfssWAQL--YGI 325
Cdd:cd23964   276 RKL---WRKLheEGI 287
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 106-302 5.93e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 53.22  E-value: 5.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 106 NQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTG-YSADVGNKTTFrVVAHSSVFrvLRKPQEFvnrtpetvfifwg 184
Cdd:cd23991    65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNL-VTANPSII--SIKYAKL------------- 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 185 ppNKMQKPQGSLLRVIQRAGLAFPnmeAYAVSQARMQQFDDLFRGETGKDREK------------SHSW---------LS 243
Cdd:cd23991   129 --NERRKPFLETVSVYGDAFLLLP---AFSYRSNTALSFKVYYTLEDFKAKQKviffhpiylkhlAQFWrskgvqvyrLS 203

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2170955333 244 TGWFTMVIAVELCDHVHVYGMVPpdyCSQRPRLQRMPYHYYEPKGPDECVTYIQNEHSR 302
Cdd:cd23991   204 TGLMITSAALELCEEVKLYGFWP---FSKNTEGKPISHHYYDNQLPKPGFHSMPKEFYQ 259
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 87-290 3.11e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 50.98  E-value: 3.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333  87 SFSNAYFPILGNKT-LPSRCNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAP-TTGYSADVGNKTTFrVVAHSSVFR- 163
Cdd:cd23989    44 TVDNETYSLFPQDTpLQLPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKTQL-VTANPSIIDk 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 164 ----VLRKPQEFVnrtpETVFIF-----WGPPNKMQKPQGSLLRVIQraglafpNMEAYAVSQARMQQFDDLFR--GETG 232
Cdd:cd23989   123 rfqnLLWSRKSFV----ESMKVYgrsyiYMPAFSMKTGTDPSLRVYY-------TLADVGANQTVLFANPNFLRnvGKFW 191

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2170955333 233 KDREKSHSWLSTGWFTMVIAVELCDHVHVYGMVPpdyCSQRPRLQRMPYHYYEPKGPD 290
Cdd:cd23989   192 KSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWP---FSVDLDERTISHHYYDNVLPD 246
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 103-287 1.05e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 49.75  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 103 SRCNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSSVFRVLRK---------PQefvn 173
Cdd:cd23974    82 SPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAyagvgfngpPQ---- 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 174 rTPETVFIFWGPPNK--MQKPQGSLLRVIQRAGLAFPNMEAYAVSQARMQQF------------DDLFRGETGKDREKSH 239
Cdd:cd23974   158 -SKETRYIFLPDHDRdyLLVKAALTHTPIDRGRDKSKRPSKYFGKDVTAEKFkiyhpdfirylrNRFLWSPILNTKQRDI 236

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 2170955333 240 SWLSTGWFTMVIAVELCDHVHVYGMVPPDYcsqrprlQRMPYHYYEPK 287
Cdd:cd23974   237 YRPSTGAVMLLAALHTCDQVSAYGFMTPDY-------GKYSDHYYDKT 277
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 101-287 3.19e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 47.90  E-value: 3.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 101 LPSRCNQCVIVTSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSSVFRVLRKPQEF-VNRTPET- 178
Cdd:cd23972    78 TPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYGFTVNTMKNSLISYWNLgFTRTPQGq 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2170955333 179 ----VFIfwgpPNKMQkpQGSLLR-VIQraGLAFPN-------MEAYAVSQARMQQFD----DLFRGETGK-------DR 235
Cdd:cd23972   158 dlqyIFI----PSDIR--DYVMLRsAIL--GVPVPEgldkgdrPHKYFGPEASAKKFKllhpDFISYLTDRflkskllNT 229

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2170955333 236 EKSHSWL-STGWFTMVIAVELCDHVHVYGMVPPDYcsqrprlQRMPYHYYEPK 287
Cdd:cd23972   230 HYGHLYMpSTGALMLLTALHTCDQVSAYGFITSNY-------WKFSDHYYERK 275
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH