NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|121114296|ref|NP_001795|]
View 

homeobox protein CDX-1 [Homo sapiens]

Protein Classification

homeobox domain-containing protein( domain architecture ID 11152543)

homeobox domain-containing protein similar to double homeobox protein that may act as a transcription factor

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
156-211 4.41e-27

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.50  E-value: 4.41e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 121114296  156 KYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERK 211
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Caudal_act pfam04731
Caudal like protein activation region; This family consists of the amino termini of proteins ...
 13-142 4.26e-16

Caudal like protein activation region; This family consists of the amino termini of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway. Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (pfam00046).


:

Pssm-ID: 461413 [Multi-domain]  Cd Length: 136  Bit Score: 72.86  E-value: 4.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121114296   13 VYPGPARPASLGLGPQAYGPPAPPPappqypDFSSYSHVEPAP---APPTAWGAPFPAPKDDWAA------AYGPGPAAP 83
Cdd:pfam04731   1 MYPGSVRHPGLNLPAQNFVAPPQYS------DYMGYHHVPGMDphgQSLGAWGSPYGPPREDWNAygpgpsSTVGTAPMN 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 121114296   84 AASPASLAFGPPpDFSPVPAPPGPGPGLLAQPLGGPGTPSSPGAQRPTPYEWMRRSVAA 142
Cdd:pfam04731  75 DASPGQIAYSPP-DYSSLHPPGPSSGLSLPPPLNSSLEQLSPSRQRRSPYEWMRKTVQV 132
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
156-211 4.41e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.50  E-value: 4.41e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 121114296  156 KYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERK 211
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 156-210 7.86e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 90.77  E-value: 7.86e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 121114296   156 KYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKER 210
Cdd:smart00389   3 RKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 156-211 7.87e-24

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 90.77  E-value: 7.87e-24
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 121114296 156 KYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERK 211
Cdd:cd00086    2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
Caudal_act pfam04731
Caudal like protein activation region; This family consists of the amino termini of proteins ...
 13-142 4.26e-16

Caudal like protein activation region; This family consists of the amino termini of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway. Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (pfam00046).


Pssm-ID: 461413 [Multi-domain]  Cd Length: 136  Bit Score: 72.86  E-value: 4.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121114296   13 VYPGPARPASLGLGPQAYGPPAPPPappqypDFSSYSHVEPAP---APPTAWGAPFPAPKDDWAA------AYGPGPAAP 83
Cdd:pfam04731   1 MYPGSVRHPGLNLPAQNFVAPPQYS------DYMGYHHVPGMDphgQSLGAWGSPYGPPREDWNAygpgpsSTVGTAPMN 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 121114296   84 AASPASLAFGPPpDFSPVPAPPGPGPGLLAQPLGGPGTPSSPGAQRPTPYEWMRRSVAA 142
Cdd:pfam04731  75 DASPGQIAYSPP-DYSSLHPPGPSSGLSLPPPLNSSLEQLSPSRQRRSPYEWMRKTVQV 132
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
158-211 3.54e-10

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 57.06  E-value: 3.54e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121114296 158 RVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERK 211
Cdd:COG5576   55 RRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKK 108
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
156-211 4.41e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.50  E-value: 4.41e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 121114296  156 KYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERK 211
Cdd:pfam00046   2 RKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 156-210 7.86e-24

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 90.77  E-value: 7.86e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 121114296   156 KYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKER 210
Cdd:smart00389   3 RKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 156-211 7.87e-24

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 90.77  E-value: 7.87e-24
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 121114296 156 KYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERK 211
Cdd:cd00086    2 RKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
Caudal_act pfam04731
Caudal like protein activation region; This family consists of the amino termini of proteins ...
 13-142 4.26e-16

Caudal like protein activation region; This family consists of the amino termini of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway. Caudal family proteins are involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium, and are important in differentiation and maintenance of the intestinal epithelial lining. Caudal proteins always have a homeobox DNA binding domain (pfam00046).


Pssm-ID: 461413 [Multi-domain]  Cd Length: 136  Bit Score: 72.86  E-value: 4.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 121114296   13 VYPGPARPASLGLGPQAYGPPAPPPappqypDFSSYSHVEPAP---APPTAWGAPFPAPKDDWAA------AYGPGPAAP 83
Cdd:pfam04731   1 MYPGSVRHPGLNLPAQNFVAPPQYS------DYMGYHHVPGMDphgQSLGAWGSPYGPPREDWNAygpgpsSTVGTAPMN 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 121114296   84 AASPASLAFGPPpDFSPVPAPPGPGPGLLAQPLGGPGTPSSPGAQRPTPYEWMRRSVAA 142
Cdd:pfam04731  75 DASPGQIAYSPP-DYSSLHPPGPSSGLSLPPPLNSSLEQLSPSRQRRSPYEWMRKTVQV 132
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
158-211 3.54e-10

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 57.06  E-value: 3.54e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 121114296 158 RVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERK 211
Cdd:COG5576   55 RRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKK 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH