major centromere autoantigen B [Homo sapiens]
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
DDE_1 | pfam03184 | DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ... |
222-384 | 4.09e-55 | ||||
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. Interestingly this family also includes the CENP-B protein. This domain in that protein appears to have lost the metal binding residues and is unlikely to have endonuclease activity. Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere. : Pssm-ID: 367380 Cd Length: 177 Bit Score: 184.52 E-value: 4.09e-55
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CENP-B_dimeriz super family | cl07586 | Centromere protein B dimerization domain; The centromere protein B (CENP-B) dimerization ... |
539-598 | 2.92e-39 | ||||
Centromere protein B dimerization domain; The centromere protein B (CENP-B) dimerization domain is composed of two alpha-helices, which are folded into an antiparallel configuration. dimerization of CENP-B is mediated by this domain, in which monomers dimerize to form a symmetrical, antiparallel, four-helix bundle structure with a large hydrophobic patch in which 23 residues of one monomer form van der Waals contacts with the other monomer. This CENP-B dimer configuration may be suitable for capturing two distant CENP-B boxes during centromeric heterochromatin formation. The actual alignment was detected with superfamily member pfam09026: Pssm-ID: 462657 Cd Length: 100 Bit Score: 139.13 E-value: 2.92e-39
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CENPB | smart00674 | Putative DNA-binding domain in centromere protein B, mouse jerky and transposases; |
74-135 | 4.46e-20 | ||||
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases; : Pssm-ID: 197828 Cd Length: 66 Bit Score: 84.27 E-value: 4.46e-20
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CENP-B_N | pfam04218 | CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein ... |
2-56 | 1.36e-19 | ||||
CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere. Within the N-terminal 125 residues, there is a DNA-binding region, which binds to a corresponding 17bp CENP-B box sequence. CENP-B dimers either bind two separate DNA molecules or alternatively, they may bind two CENP-B boxes on one DNA molecule, with the intervening stretch of DNA forming a loop structure. The CENP-B DNA-binding domain consists of two repeating domains, RP1 and RP2. This family corresponds to RP1 has been shown to consist of four helices in a helix-turn-helix structure. : Pssm-ID: 461229 Cd Length: 53 Bit Score: 82.46 E-value: 1.36e-19
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Name | Accession | Description | Interval | E-value | ||||
DDE_1 | pfam03184 | DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ... |
222-384 | 4.09e-55 | ||||
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. Interestingly this family also includes the CENP-B protein. This domain in that protein appears to have lost the metal binding residues and is unlikely to have endonuclease activity. Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere. Pssm-ID: 367380 Cd Length: 177 Bit Score: 184.52 E-value: 4.09e-55
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CENP-B_dimeriz | pfam09026 | Centromere protein B dimerization domain; The centromere protein B (CENP-B) dimerization ... |
539-598 | 2.92e-39 | ||||
Centromere protein B dimerization domain; The centromere protein B (CENP-B) dimerization domain is composed of two alpha-helices, which are folded into an antiparallel configuration. dimerization of CENP-B is mediated by this domain, in which monomers dimerize to form a symmetrical, antiparallel, four-helix bundle structure with a large hydrophobic patch in which 23 residues of one monomer form van der Waals contacts with the other monomer. This CENP-B dimer configuration may be suitable for capturing two distant CENP-B boxes during centromeric heterochromatin formation. Pssm-ID: 462657 Cd Length: 100 Bit Score: 139.13 E-value: 2.92e-39
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CENPB | smart00674 | Putative DNA-binding domain in centromere protein B, mouse jerky and transposases; |
74-135 | 4.46e-20 | ||||
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases; Pssm-ID: 197828 Cd Length: 66 Bit Score: 84.27 E-value: 4.46e-20
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CENP-B_N | pfam04218 | CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein ... |
2-56 | 1.36e-19 | ||||
CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere. Within the N-terminal 125 residues, there is a DNA-binding region, which binds to a corresponding 17bp CENP-B box sequence. CENP-B dimers either bind two separate DNA molecules or alternatively, they may bind two CENP-B boxes on one DNA molecule, with the intervening stretch of DNA forming a loop structure. The CENP-B DNA-binding domain consists of two repeating domains, RP1 and RP2. This family corresponds to RP1 has been shown to consist of four helices in a helix-turn-helix structure. Pssm-ID: 461229 Cd Length: 53 Bit Score: 82.46 E-value: 1.36e-19
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HTH_Tnp_Tc5 | pfam03221 | Tc5 transposase DNA-binding domain; |
74-133 | 7.67e-18 | ||||
Tc5 transposase DNA-binding domain; Pssm-ID: 460850 Cd Length: 63 Bit Score: 77.67 E-value: 7.67e-18
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InsE | COG2963 | Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons]; |
1-44 | 2.91e-03 | ||||
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons]; Pssm-ID: 442203 [Multi-domain] Cd Length: 93 Bit Score: 37.21 E-value: 2.91e-03
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Name | Accession | Description | Interval | E-value | ||||
DDE_1 | pfam03184 | DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are ... |
222-384 | 4.09e-55 | ||||
DDE superfamily endonuclease; This family of proteins are related to pfam00665 and are probably endonucleases of the DDE superfamily. Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contain three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific site followed by a strand transfer reaction. Interestingly this family also includes the CENP-B protein. This domain in that protein appears to have lost the metal binding residues and is unlikely to have endonuclease activity. Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere. Pssm-ID: 367380 Cd Length: 177 Bit Score: 184.52 E-value: 4.09e-55
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CENP-B_dimeriz | pfam09026 | Centromere protein B dimerization domain; The centromere protein B (CENP-B) dimerization ... |
539-598 | 2.92e-39 | ||||
Centromere protein B dimerization domain; The centromere protein B (CENP-B) dimerization domain is composed of two alpha-helices, which are folded into an antiparallel configuration. dimerization of CENP-B is mediated by this domain, in which monomers dimerize to form a symmetrical, antiparallel, four-helix bundle structure with a large hydrophobic patch in which 23 residues of one monomer form van der Waals contacts with the other monomer. This CENP-B dimer configuration may be suitable for capturing two distant CENP-B boxes during centromeric heterochromatin formation. Pssm-ID: 462657 Cd Length: 100 Bit Score: 139.13 E-value: 2.92e-39
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CENPB | smart00674 | Putative DNA-binding domain in centromere protein B, mouse jerky and transposases; |
74-135 | 4.46e-20 | ||||
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases; Pssm-ID: 197828 Cd Length: 66 Bit Score: 84.27 E-value: 4.46e-20
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CENP-B_N | pfam04218 | CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein ... |
2-56 | 1.36e-19 | ||||
CENP-B N-terminal DNA-binding domain; Centromere Protein B (CENP-B) is a DNA-binding protein localized to the centromere. Within the N-terminal 125 residues, there is a DNA-binding region, which binds to a corresponding 17bp CENP-B box sequence. CENP-B dimers either bind two separate DNA molecules or alternatively, they may bind two CENP-B boxes on one DNA molecule, with the intervening stretch of DNA forming a loop structure. The CENP-B DNA-binding domain consists of two repeating domains, RP1 and RP2. This family corresponds to RP1 has been shown to consist of four helices in a helix-turn-helix structure. Pssm-ID: 461229 Cd Length: 53 Bit Score: 82.46 E-value: 1.36e-19
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HTH_Tnp_Tc5 | pfam03221 | Tc5 transposase DNA-binding domain; |
74-133 | 7.67e-18 | ||||
Tc5 transposase DNA-binding domain; Pssm-ID: 460850 Cd Length: 63 Bit Score: 77.67 E-value: 7.67e-18
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HTH_24 | pfam13412 | Winged helix-turn-helix DNA-binding; |
15-48 | 2.12e-03 | ||||
Winged helix-turn-helix DNA-binding; Pssm-ID: 404317 [Multi-domain] Cd Length: 45 Bit Score: 36.26 E-value: 2.12e-03
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InsE | COG2963 | Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons]; |
1-44 | 2.91e-03 | ||||
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons]; Pssm-ID: 442203 [Multi-domain] Cd Length: 93 Bit Score: 37.21 E-value: 2.91e-03
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Blast search parameters | ||||
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