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Conserved domains on  [gi|4503109|ref|NP_001890|]
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cystatin-S precursor [Homo sapiens]

Protein Classification

cystatin family protein( domain architecture ID 11249387)

cystatin family protein similar to cystatins which are a family of cysteine protease inhibitors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 30-139 6.53e-37

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


:

Pssm-ID: 214484  Cd Length: 107  Bit Score: 122.15  E-value: 6.53e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503109      30 IPGGIYDADLNDEWVQRALHFAISEYNKATEDEYYRRPLQVLRAREQTFGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQ 109
Cdd:smart00043   2 CLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFLDQ 81

                           90       100       110
                   ....*....|....*....|....*....|
gi 4503109     110 PELQkkqlCSFEIYEVPWEDRMSLVNSRCQ 139
Cdd:smart00043  82 GEKF----CTAKVWEKPWENKIKLVEFKCT 107
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 30-139 6.53e-37

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 122.15  E-value: 6.53e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503109      30 IPGGIYDADLNDEWVQRALHFAISEYNKATEDEYYRRPLQVLRAREQTFGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQ 109
Cdd:smart00043   2 CLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFLDQ 81

                           90       100       110
                   ....*....|....*....|....*....|
gi 4503109     110 PELQkkqlCSFEIYEVPWEDRMSLVNSRCQ 139
Cdd:smart00043  82 GEKF----CTAKVWEKPWENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 32-138 3.15e-33

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 112.57  E-value: 3.15e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503109   32 GGIYDADLNDEWVQRALHFAISEYNKATEDEYYRrPLQVLRAREQTFGGVNYFFDVEVGRTICTKSQPNLDtCAFHEQPE 111
Cdd:cd00042   1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYLE-FFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLD-CPDCKLLE 78

                        90       100
                ....*....|....*....|....*..
gi 4503109  112 LQKKQLCSFEIYEVPWEDRMSLVNSRC 138
Cdd:cd00042  79 EGKKKFCTAKVWEKPWENFKELLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 32-127 1.13e-32

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 110.89  E-value: 1.13e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503109     32 GGIYDADLNDEWVQRALHFAISEYNKATeDEYYRRPLQVLRAREQTFGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPe 111
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAKT-DNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSKKLLEDCPLLDEK- 78

                          90
                  ....*....|....*.
gi 4503109    112 lqKKQLCSFEIYEVPW 127
Cdd:pfam00031  79 --WLGLCSAQVYKVPW 92
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 30-139 6.53e-37

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 122.15  E-value: 6.53e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503109      30 IPGGIYDADLNDEWVQRALHFAISEYNKATEDEYYRRPLQVLRAREQTFGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQ 109
Cdd:smart00043   2 CLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSVDLENCPFLDQ 81

                           90       100       110
                   ....*....|....*....|....*....|
gi 4503109     110 PELQkkqlCSFEIYEVPWEDRMSLVNSRCQ 139
Cdd:smart00043  82 GEKF----CTAKVWEKPWENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 32-138 3.15e-33

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 112.57  E-value: 3.15e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503109   32 GGIYDADLNDEWVQRALHFAISEYNKATEDEYYRrPLQVLRAREQTFGGVNYFFDVEVGRTICTKSQPNLDtCAFHEQPE 111
Cdd:cd00042   1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYLE-FFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLD-CPDCKLLE 78

                        90       100
                ....*....|....*....|....*..
gi 4503109  112 LQKKQLCSFEIYEVPWEDRMSLVNSRC 138
Cdd:cd00042  79 EGKKKFCTAKVWEKPWENFKELLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 32-127 1.13e-32

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 110.89  E-value: 1.13e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503109     32 GGIYDADLNDEWVQRALHFAISEYNKATeDEYYRRPLQVLRAREQTFGGVNYFFDVEVGRTICTKSQPNLDTCAFHEQPe 111
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAKT-DNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSKKLLEDCPLLDEK- 78

                          90
                  ....*....|....*.
gi 4503109    112 lqKKQLCSFEIYEVPW 127
Cdd:pfam00031  79 --WLGLCSAQVYKVPW 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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