NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|119964718|ref|NP_001935|]
View 

desmoglein-3 preproprotein [Homo sapiens]

Protein Classification

Cadherin_repeat domain-containing protein( domain architecture ID 11254398)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 165-263 2.29e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 2.29e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718 165 EIEENSASNSLVMILNATDADEPNhlNSKIAFKIVSQEPAGtpMFLLSRNTGEVRTlTNSLDREQASSYRLVVSGADKDG 244
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNEDG--LFSIDPSTGEITT-AKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 119964718 245 EGLSTQCECNIKVKDVNDN 263
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
272-375 1.65e-17

Cadherin domain;


:

Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.50  E-value: 1.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718  272 YSARIEENILS-SELLRFQVTDLDEeyTDNWLAVYFFTSGNEGNWFEIQTDPrtneGILKVVKALDYEQLQSVKLSIAVK 350
Cdd:pfam00028   1 YSASVPENAPVgTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....*
gi 119964718  351 NKAEFHQSvisryrvQSTPVTIQVI 375
Cdd:pfam00028  75 DSGGPPLS-------STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 82-155 1.24e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.99  E-value: 1.24e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119964718    82 KITYRISGvgidQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPP 155
Cdd:smart00112  12 KVTYSILS----GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 402-491 7.68e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 53.86  E-value: 7.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718 402 VDYILGTYQAIDEDTNkAASNVKY-VMGRNDGGYLMIDSKTAEIKFVKNMNRDSTfivnKTITAEVLAIDEYT-GKTSTG 479
Cdd:cd11304   12 PGTVVLTVSATDPDSG-ENGEVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQ----SSYTLTVTATDGGGpPLSSTA 86

                         90
                 ....*....|..
gi 119964718 480 TVYVRVPDFNDN 491
Cdd:cd11304   87 TVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 165-263 2.29e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 2.29e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718 165 EIEENSASNSLVMILNATDADEPNhlNSKIAFKIVSQEPAGtpMFLLSRNTGEVRTlTNSLDREQASSYRLVVSGADKDG 244
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNEDG--LFSIDPSTGEITT-AKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 119964718 245 EGLSTQCECNIKVKDVNDN 263
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
164-257 9.37e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.96  E-value: 9.37e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718  164 GEIEENSASNSLVMILNATDADEPnhLNSKIAFKIVSQEPAGtpMFLLSRNTGEVRTlTNSLDREQASSYRLVVSGADKD 243
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGG--NFRIDPDTGDIST-TKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 119964718  244 GEGLSTQCECNIKV 257
Cdd:pfam00028  78 GPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 180-265 2.49e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.47  E-value: 2.49e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718   180 NATDADEPNhlNSKIAFKIVSQEPAGtpMFLLSRNTGEVRTlTNSLDREQASSYRLVVSGADKDGEGLSTQCECNIKVKD 259
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDG--LFSIDPETGEITT-TKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 119964718   260 VNDNFP 265
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
272-375 1.65e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.50  E-value: 1.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718  272 YSARIEENILS-SELLRFQVTDLDEeyTDNWLAVYFFTSGNEGNWFEIQTDPrtneGILKVVKALDYEQLQSVKLSIAVK 350
Cdd:pfam00028   1 YSASVPENAPVgTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....*
gi 119964718  351 NKAEFHQSvisryrvQSTPVTIQVI 375
Cdd:pfam00028  75 DSGGPPLS-------STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 271-377 6.92e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 6.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718 271 QYSARIEENI-LSSELLRFQVTDLDEEytDNWLAVYFFTSGNEGNWFEIqtDPRTneGILKVVKALDYEQLQSVKLSIAV 349
Cdd:cd11304    1 SYEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*...
gi 119964718 350 KNKAEFHQSVisryrvqSTPVTIQVINV 377
Cdd:cd11304   75 TDGGGPPLSS-------TATVTITVLDV 95
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 82-155 1.24e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.99  E-value: 1.24e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119964718    82 KITYRISGvgidQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPP 155
Cdd:smart00112  12 KVTYSILS----GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 62-153 1.95e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.26  E-value: 1.95e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718  62 EDNSKRNPIAKIT---SDYQATQKITYRISGvgidQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVE 138
Cdd:cd11304    8 ENAPPGTVVLTVSatdPDSGENGEVTYSIVS----GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 119964718 139 KPLILTVKILDINDN 153
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
58-148 4.72e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 4.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718   58 CREGE-DNSKRNPIAKITSDYQATQKITYRISGvgidQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLD 136
Cdd:pfam00028   5 VPENApVGTEVLTVTATDPDLGPNGRIFYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|..
gi 119964718  137 VEKPLILTVKIL 148
Cdd:pfam00028  81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 289-377 7.41e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.20  E-value: 7.41e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718   289 QVTDLDEEytDNWLAVYFFTSGNEGNWFEIqtDPRTneGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVisryrvqST 368
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGGPPLSS-------TA 67


                   ....*....
gi 119964718   369 PVTIQVINV 377
Cdd:smart00112  68 TVTITVLDV 76
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 402-491 7.68e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 53.86  E-value: 7.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718 402 VDYILGTYQAIDEDTNkAASNVKY-VMGRNDGGYLMIDSKTAEIKFVKNMNRDSTfivnKTITAEVLAIDEYT-GKTSTG 479
Cdd:cd11304   12 PGTVVLTVSATDPDSG-ENGEVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQ----SSYTLTVTATDGGGpPLSSTA 86

                         90
                 ....*....|..
gi 119964718 480 TVYVRVPDFNDN 491
Cdd:cd11304   87 TVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 410-493 3.09e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.58  E-value: 3.09e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718   410 QAIDEDTNkAASNVKYVM-GRNDGGYLMIDSKTAEIKFVKNMNRDSTfivnKTITAEVLAIDEYT-GKTSTGTVYVRVPD 487
Cdd:smart00112   1 SATDADSG-ENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQ----PEYTLTVEATDGGGpPLSSTATVTITVLD 75


                   ....*.
gi 119964718   488 FNDNCP 493
Cdd:smart00112  76 VNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 165-263 2.29e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 2.29e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718 165 EIEENSASNSLVMILNATDADEPNhlNSKIAFKIVSQEPAGtpMFLLSRNTGEVRTlTNSLDREQASSYRLVVSGADKDG 244
Cdd:cd11304    5 SVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIVSGNEDG--LFSIDPSTGEITT-AKPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 119964718 245 EGLSTQCECNIKVKDVNDN 263
Cdd:cd11304   80 PPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
164-257 9.37e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.96  E-value: 9.37e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718  164 GEIEENSASNSLVMILNATDADEPnhLNSKIAFKIVSQEPAGtpMFLLSRNTGEVRTlTNSLDREQASSYRLVVSGADKD 243
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGG--NFRIDPDTGDIST-TKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 119964718  244 GEGLSTQCECNIKV 257
Cdd:pfam00028  78 GPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 180-265 2.49e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.47  E-value: 2.49e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718   180 NATDADEPNhlNSKIAFKIVSQEPAGtpMFLLSRNTGEVRTlTNSLDREQASSYRLVVSGADKDGEGLSTQCECNIKVKD 259
Cdd:smart00112   1 SATDADSGE--NGKVTYSILSGNDDG--LFSIDPETGEITT-TKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 119964718   260 VNDNFP 265
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
272-375 1.65e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.50  E-value: 1.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718  272 YSARIEENILS-SELLRFQVTDLDEeyTDNWLAVYFFTSGNEGNWFEIQTDPrtneGILKVVKALDYEQLQSVKLSIAVK 350
Cdd:pfam00028   1 YSASVPENAPVgTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|....*
gi 119964718  351 NKAEFHQSvisryrvQSTPVTIQVI 375
Cdd:pfam00028  75 DSGGPPLS-------STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 271-377 6.92e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 6.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718 271 QYSARIEENI-LSSELLRFQVTDLDEEytDNWLAVYFFTSGNEGNWFEIqtDPRTneGILKVVKALDYEQLQSVKLSIAV 349
Cdd:cd11304    1 SYEVSVPENApPGTVVLTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                         90       100
                 ....*....|....*....|....*...
gi 119964718 350 KNKAEFHQSVisryrvqSTPVTIQVINV 377
Cdd:cd11304   75 TDGGGPPLSS-------TATVTITVLDV 95
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 82-155 1.24e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 66.99  E-value: 1.24e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 119964718    82 KITYRISGvgidQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPP 155
Cdd:smart00112  12 KVTYSILS----GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 62-153 1.95e-12

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 64.26  E-value: 1.95e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718  62 EDNSKRNPIAKIT---SDYQATQKITYRISGvgidQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVE 138
Cdd:cd11304    8 ENAPPGTVVLTVSatdPDSGENGEVTYSIVS----GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                         90
                 ....*....|....*
gi 119964718 139 KPLILTVKILDINDN 153
Cdd:cd11304   84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
58-148 4.72e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 4.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718   58 CREGE-DNSKRNPIAKITSDYQATQKITYRISGvgidQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLD 136
Cdd:pfam00028   5 VPENApVGTEVLTVTATDPDLGPNGRIFYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|..
gi 119964718  137 VEKPLILTVKIL 148
Cdd:pfam00028  81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 289-377 7.41e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.20  E-value: 7.41e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718   289 QVTDLDEEytDNWLAVYFFTSGNEGNWFEIqtDPRTneGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVisryrvqST 368
Cdd:smart00112   1 SATDADSG--ENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDGGGPPLSS-------TA 67


                   ....*....
gi 119964718   369 PVTIQVINV 377
Cdd:smart00112  68 TVTITVLDV 76
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 402-491 7.68e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 53.86  E-value: 7.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718 402 VDYILGTYQAIDEDTNkAASNVKY-VMGRNDGGYLMIDSKTAEIKFVKNMNRDSTfivnKTITAEVLAIDEYT-GKTSTG 479
Cdd:cd11304   12 PGTVVLTVSATDPDSG-ENGEVTYsIVSGNEDGLFSIDPSTGEITTAKPLDREEQ----SSYTLTVTATDGGGpPLSSTA 86

                         90
                 ....*....|..
gi 119964718 480 TVYVRVPDFNDN 491
Cdd:cd11304   87 TVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 410-493 3.09e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.58  E-value: 3.09e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718   410 QAIDEDTNkAASNVKYVM-GRNDGGYLMIDSKTAEIKFVKNMNRDSTfivnKTITAEVLAIDEYT-GKTSTGTVYVRVPD 487
Cdd:smart00112   1 SATDADSG-ENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQ----PEYTLTVEATDGGGpPLSSTATVTITVLD 75


                   ....*.
gi 119964718   488 FNDNCP 493
Cdd:smart00112  76 VNDNAP 81
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 58-153 4.14e-06

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 46.18  E-value: 4.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119964718  58 CREGEDNSKRnpIAKITSDYQATQKITYRISGVGIDQPPfGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDV 137
Cdd:cd00031    6 AVEGRSRGSF--RVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVP 82

                         90
                 ....*....|....*.
gi 119964718 138 EKPLILTVKILDINDN 153
Cdd:cd00031   83 QTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH