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Conserved domains on  [gi|4504567|ref|NP_002154|]
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interferon regulatory factor 8 isoform 2 [Homo sapiens]

Protein Classification

interferon regulatory factor( domain architecture ID 10457095)

interferon regulatory factor (IRF) is a transcriptional regulator that is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 202-381 1.64e-85

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


:

Pssm-ID: 463076  Cd Length: 180  Bit Score: 258.73  E-value: 1.64e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504567    202 FSQMVISFYYGGKLVGQATTTCPEGCRLSLsQPGLPGTKLYGPEGLELVRFPPADAIPSERQRQVTRKLFGHLERGVLLH 281
Cdd:pfam10401   1 DTDLEITFFYRGRLVLELTVSSPEGCRLSY-GPPDPQVALYGPVALQQVRFPDPDGIPDERQREYTRRLLNVLERGLLLW 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504567    282 SSRQGVFVKRLCQGRVFCSGNAVVCKGRPNKLERDEVVQVFDTSQFFRELQQFYNSQGRLPDGRVVLCFGEEFPDMAPLR 361
Cdd:pfam10401  80 VAGQGLYAKRLCQSRVFWSGPEAPGGDKPNKLERDATVKLFDLAKFLRELILFQEGRGRSPDYTITLCFGEEWPDDKPRE 159

                         170       180
                  ....*....|....*....|
gi 4504567    362 SKLILVQIEQLYVRQLAEEA 381
Cdd:pfam10401 160 KKLITVQVVPLFARQLLEMA 179
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 9-113 6.04e-68

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


:

Pssm-ID: 459863  Cd Length: 106  Bit Score: 210.88  E-value: 6.04e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504567      9 RLRQWLIEQIDSSMYPGLIWENEEKSMFRIPWKHAGKQDYNQEVDASIFKAWAVFKGKFKEG-DKAEPATWKTRLRCALN 87
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNQEEDAAIFKAWAVHTGKYREGvDKPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 4504567     88 KSPDFEEVTDRSQLDISEPYKVYRIV 113
Cdd:pfam00605  81 KLPDFEEVKDRSKDDGSDPYKVYRIL 106
 
Name Accession Description Interval E-value
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 202-381 1.64e-85

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 258.73  E-value: 1.64e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504567    202 FSQMVISFYYGGKLVGQATTTCPEGCRLSLsQPGLPGTKLYGPEGLELVRFPPADAIPSERQRQVTRKLFGHLERGVLLH 281
Cdd:pfam10401   1 DTDLEITFFYRGRLVLELTVSSPEGCRLSY-GPPDPQVALYGPVALQQVRFPDPDGIPDERQREYTRRLLNVLERGLLLW 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504567    282 SSRQGVFVKRLCQGRVFCSGNAVVCKGRPNKLERDEVVQVFDTSQFFRELQQFYNSQGRLPDGRVVLCFGEEFPDMAPLR 361
Cdd:pfam10401  80 VAGQGLYAKRLCQSRVFWSGPEAPGGDKPNKLERDATVKLFDLAKFLRELILFQEGRGRSPDYTITLCFGEEWPDDKPRE 159

                         170       180
                  ....*....|....*....|
gi 4504567    362 SKLILVQIEQLYVRQLAEEA 381
Cdd:pfam10401 160 KKLITVQVVPLFARQLLEMA 179
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 9-113 6.04e-68

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 210.88  E-value: 6.04e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504567      9 RLRQWLIEQIDSSMYPGLIWENEEKSMFRIPWKHAGKQDYNQEVDASIFKAWAVFKGKFKEG-DKAEPATWKTRLRCALN 87
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNQEEDAAIFKAWAVHTGKYREGvDKPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 4504567     88 KSPDFEEVTDRSQLDISEPYKVYRIV 113
Cdd:pfam00605  81 KLPDFEEVKDRSKDDGSDPYKVYRIL 106
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 9-115 2.78e-53

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 173.29  E-value: 2.78e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504567       9 RLRQWLIEQIDSSMYPGLIWENEEKSMFRIPWKHAGKQDYNQEVDASIFKAWAVFKGKFKEG-DKAEPATWKTRLRCALN 87
Cdd:smart00348   1 RLRPWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFDEERDAEIFKAYCVARGIYQPGgRSPDPKTWKARLRCALR 80

                           90       100
                   ....*....|....*....|....*...
gi 4504567      88 KSPDFEEVTDRSQlDISEPYKVYRIVPE 115
Cdd:smart00348  81 KSRDFEEIKDAST-DPPDPYRVYRLLPE 107
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 7-114 1.34e-51

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 169.01  E-value: 1.34e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504567    7 GRRLRQWLIEQIDSSMYPGLIWENEEKSMFRIPWKHAGKQDyNQEVDASIFKAWAVFKGKFKEGDKAEPATWKTRLRCAL 86
Cdd:cd00103   1 KMRLRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHD-VQEADAKIFKAWAVERGIYQPGGTPDPAEWKARLLCAL 79

                        90       100
                ....*....|....*....|....*...
gi 4504567   87 NKSPDFEEVTDRSQLDISEPYKVYRIVP 114
Cdd:cd00103  80 RSSRGFEEVKDKSKDTPGDPHRVYRLLP 107
 
Name Accession Description Interval E-value
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 202-381 1.64e-85

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 258.73  E-value: 1.64e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504567    202 FSQMVISFYYGGKLVGQATTTCPEGCRLSLsQPGLPGTKLYGPEGLELVRFPPADAIPSERQRQVTRKLFGHLERGVLLH 281
Cdd:pfam10401   1 DTDLEITFFYRGRLVLELTVSSPEGCRLSY-GPPDPQVALYGPVALQQVRFPDPDGIPDERQREYTRRLLNVLERGLLLW 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504567    282 SSRQGVFVKRLCQGRVFCSGNAVVCKGRPNKLERDEVVQVFDTSQFFRELQQFYNSQGRLPDGRVVLCFGEEFPDMAPLR 361
Cdd:pfam10401  80 VAGQGLYAKRLCQSRVFWSGPEAPGGDKPNKLERDATVKLFDLAKFLRELILFQEGRGRSPDYTITLCFGEEWPDDKPRE 159

                         170       180
                  ....*....|....*....|
gi 4504567    362 SKLILVQIEQLYVRQLAEEA 381
Cdd:pfam10401 160 KKLITVQVVPLFARQLLEMA 179
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 9-113 6.04e-68

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 210.88  E-value: 6.04e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504567      9 RLRQWLIEQIDSSMYPGLIWENEEKSMFRIPWKHAGKQDYNQEVDASIFKAWAVFKGKFKEG-DKAEPATWKTRLRCALN 87
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNQEEDAAIFKAWAVHTGKYREGvDKPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 4504567     88 KSPDFEEVTDRSQLDISEPYKVYRIV 113
Cdd:pfam00605  81 KLPDFEEVKDRSKDDGSDPYKVYRIL 106
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 9-115 2.78e-53

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 173.29  E-value: 2.78e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504567       9 RLRQWLIEQIDSSMYPGLIWENEEKSMFRIPWKHAGKQDYNQEVDASIFKAWAVFKGKFKEG-DKAEPATWKTRLRCALN 87
Cdd:smart00348   1 RLRPWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFDEERDAEIFKAYCVARGIYQPGgRSPDPKTWKARLRCALR 80

                           90       100
                   ....*....|....*....|....*...
gi 4504567      88 KSPDFEEVTDRSQlDISEPYKVYRIVPE 115
Cdd:smart00348  81 KSRDFEEIKDAST-DPPDPYRVYRLLPE 107
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 7-114 1.34e-51

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 169.01  E-value: 1.34e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504567    7 GRRLRQWLIEQIDSSMYPGLIWENEEKSMFRIPWKHAGKQDyNQEVDASIFKAWAVFKGKFKEGDKAEPATWKTRLRCAL 86
Cdd:cd00103   1 KMRLRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHD-VQEADAKIFKAWAVERGIYQPGGTPDPAEWKARLLCAL 79

                        90       100
                ....*....|....*....|....*...
gi 4504567   87 NKSPDFEEVTDRSQLDISEPYKVYRIVP 114
Cdd:cd00103  80 RSSRGFEEVKDKSKDTPGDPHRVYRLLP 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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