|
Name |
Accession |
Description |
Interval |
E-value |
| Importin_rep_6 |
pfam18829 |
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
765-874 |
1.23e-43 |
|
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.
:
Pssm-ID: 465881 Cd Length: 110 Bit Score: 153.80 E-value: 1.23e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 765 VLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSD 844
Cdd:pfam18829 1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80
|
90 100 110
....*....|....*....|....*....|
gi 1491824281 845 ILHSIFSSYKEKVLPWFEQLLPLIVNLICP 874
Cdd:pfam18829 81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
|
|
| Importin_rep_4 |
pfam18808 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
268-357 |
1.44e-29 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.
:
Pssm-ID: 408579 Cd Length: 90 Bit Score: 112.94 E-value: 1.44e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 268 DTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIVAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMA 347
Cdd:pfam18808 1 NKDLDDAARQVALELLVTLAEAAPGMCRKQPQFTNALVPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRLA 80
|
90
....*....|
gi 1491824281 348 CGLGGKLVLP 357
Cdd:pfam18808 81 CRLGGKALLP 90
|
|
| KAP95 super family |
cl27231 |
Karyopherin (importin) beta [Intracellular trafficking and secretion]; |
13-634 |
2.00e-14 |
|
Karyopherin (importin) beta [Intracellular trafficking and secretion];
The actual alignment was detected with superfamily member COG5215:
Pssm-ID: 227540 [Multi-domain] Cd Length: 858 Bit Score: 78.06 E-value: 2.00e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 13 LLLGNLLSPDNVVRKQAEETYENIPG---QSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSS-------AFDEVYPALP 82
Cdd:COG5215 9 LGKNHVLSPDPNARLRAEAQLLELQSgdfEQFISLLVQVLCDLNSNDQLRMVAGLILKNSLHAndpelqkGCSQRWLGMR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 83 SDVQTAIKSellMIIQmeTQSSMRKKVCDIAAELARNLID-EDGNNQWPEGLKFLFDSV-SSQNVGLREAALHIFWNF-- 158
Cdd:COG5215 89 HESKEQVKG---MALR--ALKSPEPRFCTMAAQLLAAIARmELPNSLWPGLMEEMVRNVgDEQPVSGKCESLGICGYHce 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 159 ---PGIFGNQQqhylDVIKRMLVQCMQDQEHPSIRTLSARATAA-------FILANEHNVALFkhfadllpgfLQAVNDS 228
Cdd:COG5215 164 seaPEDLIQMS----NVILFAIVMGALKNETTSAVRLAALKALMdslmfvqGNFCYEEERNYF----------MQVVCEA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 229 CYQNDDSVLKS----LVEIADTVPKYLRPHLEATLqLSLKLCGDTSLNNMQRQLALE--------------VIVTLSETA 290
Cdd:COG5215 230 TQGNDEELQHAafgcLNKIMMLYYKFMQSYMENAL-AALTGRFMKSQNDEVAIQAVEfwsticeeeidgemEDKYLPEVP 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 291 AAMLRKHTNIVAQTIPQMLAMMVDLEEDEDwanadeleDDDFDSNAVAGeSALDRMACGLGGKLVLPMIkEHIMQMLQNP 370
Cdd:COG5215 309 AQNHGFARAAVADVLPELLSLLEKQGEDYY--------GDDWNPSMAAS-SCLQLFAQLKGDKIMRPVL-GFVEQNIRSE 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 371 DWKYRHAGLMALSAIGEG-CHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFH-EKVIAALLQ 448
Cdd:COG5215 379 SWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHlVLEVSASLI 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 449 TMEDqgNQRVQAHAAAALINFTEDCPK------SLLIPYLDNLVKHLHSIMVLKLQELIQKGTklVLEQVVTSIASVADT 522
Cdd:COG5215 459 GLMD--CPFRSINCSWRKENLVDHIAKavreveSFLAKFYLAILNALVKGTELALNESNLRVS--LFSALGTLILICPDA 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 523 AEEKFVPYYDLFMPSLKHIVEN-----AVQKELRLLRGKTIECISLIGLAVGKEKFMQDASD-VMQLLLKT--QTDFNDM 594
Cdd:COG5215 535 VSDILAGFYDYTSKKLDECISVlgqilATEDQLLVEELQSNYIGVLEAIIRTRRRDIEDVEDqLMELFIRIleSTKPTTA 614
|
650 660 670 680
....*....|....*....|....*....|....*....|
gi 1491824281 595 EDDdpqISYMISAwarMCKILGKEFQQYLPVVMgPLMKTA 634
Cdd:COG5215 615 FGD---VYTAISA---LSTSLEERFEQYASKFI-PYLTRA 647
|
|
| Importin_rep_5 super family |
cl40106 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
1005-1051 |
3.04e-06 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.
The actual alignment was detected with superfamily member pfam18816:
Pssm-ID: 465877 Cd Length: 52 Bit Score: 45.16 E-value: 3.04e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1491824281 1005 DKEEAVQTFNYLCDLIESNHPIVLGpnntNLPKIFSIIAEGEMHEAI 1051
Cdd:pfam18816 1 DEEAAPFAYRFLAELIEQNHPAVTS----QIPKVVDSVVQALEHKSL 43
|
|
| HEAT_EZ |
pfam13513 |
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ... |
919-966 |
6.48e-04 |
|
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
:
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 38.89 E-value: 6.48e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1491824281 919 PEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENV 966
Cdd:pfam13513 1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAA 48
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Importin_rep_6 |
pfam18829 |
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
765-874 |
1.23e-43 |
|
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.
Pssm-ID: 465881 Cd Length: 110 Bit Score: 153.80 E-value: 1.23e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 765 VLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSD 844
Cdd:pfam18829 1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80
|
90 100 110
....*....|....*....|....*....|
gi 1491824281 845 ILHSIFSSYKEKVLPWFEQLLPLIVNLICP 874
Cdd:pfam18829 81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
|
|
| Importin_rep_4 |
pfam18808 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
268-357 |
1.44e-29 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.
Pssm-ID: 408579 Cd Length: 90 Bit Score: 112.94 E-value: 1.44e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 268 DTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIVAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMA 347
Cdd:pfam18808 1 NKDLDDAARQVALELLVTLAEAAPGMCRKQPQFTNALVPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRLA 80
|
90
....*....|
gi 1491824281 348 CGLGGKLVLP 357
Cdd:pfam18808 81 CRLGGKALLP 90
|
|
| KAP95 |
COG5215 |
Karyopherin (importin) beta [Intracellular trafficking and secretion]; |
13-634 |
2.00e-14 |
|
Karyopherin (importin) beta [Intracellular trafficking and secretion];
Pssm-ID: 227540 [Multi-domain] Cd Length: 858 Bit Score: 78.06 E-value: 2.00e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 13 LLLGNLLSPDNVVRKQAEETYENIPG---QSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSS-------AFDEVYPALP 82
Cdd:COG5215 9 LGKNHVLSPDPNARLRAEAQLLELQSgdfEQFISLLVQVLCDLNSNDQLRMVAGLILKNSLHAndpelqkGCSQRWLGMR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 83 SDVQTAIKSellMIIQmeTQSSMRKKVCDIAAELARNLID-EDGNNQWPEGLKFLFDSV-SSQNVGLREAALHIFWNF-- 158
Cdd:COG5215 89 HESKEQVKG---MALR--ALKSPEPRFCTMAAQLLAAIARmELPNSLWPGLMEEMVRNVgDEQPVSGKCESLGICGYHce 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 159 ---PGIFGNQQqhylDVIKRMLVQCMQDQEHPSIRTLSARATAA-------FILANEHNVALFkhfadllpgfLQAVNDS 228
Cdd:COG5215 164 seaPEDLIQMS----NVILFAIVMGALKNETTSAVRLAALKALMdslmfvqGNFCYEEERNYF----------MQVVCEA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 229 CYQNDDSVLKS----LVEIADTVPKYLRPHLEATLqLSLKLCGDTSLNNMQRQLALE--------------VIVTLSETA 290
Cdd:COG5215 230 TQGNDEELQHAafgcLNKIMMLYYKFMQSYMENAL-AALTGRFMKSQNDEVAIQAVEfwsticeeeidgemEDKYLPEVP 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 291 AAMLRKHTNIVAQTIPQMLAMMVDLEEDEDwanadeleDDDFDSNAVAGeSALDRMACGLGGKLVLPMIkEHIMQMLQNP 370
Cdd:COG5215 309 AQNHGFARAAVADVLPELLSLLEKQGEDYY--------GDDWNPSMAAS-SCLQLFAQLKGDKIMRPVL-GFVEQNIRSE 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 371 DWKYRHAGLMALSAIGEG-CHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFH-EKVIAALLQ 448
Cdd:COG5215 379 SWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHlVLEVSASLI 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 449 TMEDqgNQRVQAHAAAALINFTEDCPK------SLLIPYLDNLVKHLHSIMVLKLQELIQKGTklVLEQVVTSIASVADT 522
Cdd:COG5215 459 GLMD--CPFRSINCSWRKENLVDHIAKavreveSFLAKFYLAILNALVKGTELALNESNLRVS--LFSALGTLILICPDA 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 523 AEEKFVPYYDLFMPSLKHIVEN-----AVQKELRLLRGKTIECISLIGLAVGKEKFMQDASD-VMQLLLKT--QTDFNDM 594
Cdd:COG5215 535 VSDILAGFYDYTSKKLDECISVlgqilATEDQLLVEELQSNYIGVLEAIIRTRRRDIEDVEDqLMELFIRIleSTKPTTA 614
|
650 660 670 680
....*....|....*....|....*....|....*....|
gi 1491824281 595 EDDdpqISYMISAwarMCKILGKEFQQYLPVVMgPLMKTA 634
Cdd:COG5215 615 FGD---VYTAISA---LSTSLEERFEQYASKFI-PYLTRA 647
|
|
| HEAT_EZ |
pfam13513 |
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ... |
372-426 |
4.34e-09 |
|
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 53.52 E-value: 4.34e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1491824281 372 WKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQM 426
Cdd:pfam13513 1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
|
|
| Importin_rep_5 |
pfam18816 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
1005-1051 |
3.04e-06 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.
Pssm-ID: 465877 Cd Length: 52 Bit Score: 45.16 E-value: 3.04e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1491824281 1005 DKEEAVQTFNYLCDLIESNHPIVLGpnntNLPKIFSIIAEGEMHEAI 1051
Cdd:pfam18816 1 DEEAAPFAYRFLAELIEQNHPAVTS----QIPKVVDSVVQALEHKSL 43
|
|
| HEAT_EZ |
pfam13513 |
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ... |
919-966 |
6.48e-04 |
|
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 38.89 E-value: 6.48e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1491824281 919 PEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENV 966
Cdd:pfam13513 1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAA 48
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Importin_rep_6 |
pfam18829 |
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
765-874 |
1.23e-43 |
|
Importin repeat 6; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry represents two consecutive repeat units and includes sequences captured by pfam18808.
Pssm-ID: 465881 Cd Length: 110 Bit Score: 153.80 E-value: 1.23e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 765 VLSEIMHSFAKCIEVMGDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILTKVSD 844
Cdd:pfam18829 1 VLAEYYSSLAECIEVLGPNCLSDEQMEEFIKAINSNLTEYFERVKEREEERKDDDYDEEVEEDLEEEEETDEELLSEINK 80
|
90 100 110
....*....|....*....|....*....|
gi 1491824281 845 ILHSIFSSYKEKVLPWFEQLLPLIVNLICP 874
Cdd:pfam18829 81 AIHAIFKTHKTAFLPYFEQLLPTVVAFLND 110
|
|
| Importin_rep_4 |
pfam18808 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
268-357 |
1.44e-29 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.
Pssm-ID: 408579 Cd Length: 90 Bit Score: 112.94 E-value: 1.44e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 268 DTSLNNMQRQLALEVIVTLSETAAAMLRKHTNIVAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMA 347
Cdd:pfam18808 1 NKDLDDAARQVALELLVTLAEAAPGMCRKQPQFTNALVPICLSMMTEVDDAEDWYTSDDLDDDDNEDNYVFGEQALDRLA 80
|
90
....*....|
gi 1491824281 348 CGLGGKLVLP 357
Cdd:pfam18808 81 CRLGGKALLP 90
|
|
| KAP95 |
COG5215 |
Karyopherin (importin) beta [Intracellular trafficking and secretion]; |
13-634 |
2.00e-14 |
|
Karyopherin (importin) beta [Intracellular trafficking and secretion];
Pssm-ID: 227540 [Multi-domain] Cd Length: 858 Bit Score: 78.06 E-value: 2.00e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 13 LLLGNLLSPDNVVRKQAEETYENIPG---QSKITFLLQAIRNTTAAEEARQMAAVLLRRLLSS-------AFDEVYPALP 82
Cdd:COG5215 9 LGKNHVLSPDPNARLRAEAQLLELQSgdfEQFISLLVQVLCDLNSNDQLRMVAGLILKNSLHAndpelqkGCSQRWLGMR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 83 SDVQTAIKSellMIIQmeTQSSMRKKVCDIAAELARNLID-EDGNNQWPEGLKFLFDSV-SSQNVGLREAALHIFWNF-- 158
Cdd:COG5215 89 HESKEQVKG---MALR--ALKSPEPRFCTMAAQLLAAIARmELPNSLWPGLMEEMVRNVgDEQPVSGKCESLGICGYHce 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 159 ---PGIFGNQQqhylDVIKRMLVQCMQDQEHPSIRTLSARATAA-------FILANEHNVALFkhfadllpgfLQAVNDS 228
Cdd:COG5215 164 seaPEDLIQMS----NVILFAIVMGALKNETTSAVRLAALKALMdslmfvqGNFCYEEERNYF----------MQVVCEA 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 229 CYQNDDSVLKS----LVEIADTVPKYLRPHLEATLqLSLKLCGDTSLNNMQRQLALE--------------VIVTLSETA 290
Cdd:COG5215 230 TQGNDEELQHAafgcLNKIMMLYYKFMQSYMENAL-AALTGRFMKSQNDEVAIQAVEfwsticeeeidgemEDKYLPEVP 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 291 AAMLRKHTNIVAQTIPQMLAMMVDLEEDEDwanadeleDDDFDSNAVAGeSALDRMACGLGGKLVLPMIkEHIMQMLQNP 370
Cdd:COG5215 309 AQNHGFARAAVADVLPELLSLLEKQGEDYY--------GDDWNPSMAAS-SCLQLFAQLKGDKIMRPVL-GFVEQNIRSE 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 371 DWKYRHAGLMALSAIGEG-CHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQMATDFAPGFQKKFH-EKVIAALLQ 448
Cdd:COG5215 379 SWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHlVLEVSASLI 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 449 TMEDqgNQRVQAHAAAALINFTEDCPK------SLLIPYLDNLVKHLHSIMVLKLQELIQKGTklVLEQVVTSIASVADT 522
Cdd:COG5215 459 GLMD--CPFRSINCSWRKENLVDHIAKavreveSFLAKFYLAILNALVKGTELALNESNLRVS--LFSALGTLILICPDA 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 523 AEEKFVPYYDLFMPSLKHIVEN-----AVQKELRLLRGKTIECISLIGLAVGKEKFMQDASD-VMQLLLKT--QTDFNDM 594
Cdd:COG5215 535 VSDILAGFYDYTSKKLDECISVlgqilATEDQLLVEELQSNYIGVLEAIIRTRRRDIEDVEDqLMELFIRIleSTKPTTA 614
|
650 660 670 680
....*....|....*....|....*....|....*....|
gi 1491824281 595 EDDdpqISYMISAwarMCKILGKEFQQYLPVVMgPLMKTA 634
Cdd:COG5215 615 FGD---VYTAISA---LSTSLEERFEQYASKFI-PYLTRA 647
|
|
| HEAT_EZ |
pfam13513 |
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ... |
372-426 |
4.34e-09 |
|
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 53.52 E-value: 4.34e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1491824281 372 WKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNAVGQM 426
Cdd:pfam13513 1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
352-466 |
9.57e-09 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 55.02 E-value: 9.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 352 GKLVLPMIKEHIMQMLQNPDWKYRHAGLMALSAIGEgchqqmegilNEIVNFVLLFLQDPHPRVRYAACNAVGQMATdfa 431
Cdd:COG1413 41 GRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGD----------PEAVPALIAALKDEDPEVRRAAAEALGRLGD--- 107
|
90 100 110
....*....|....*....|....*....|....*
gi 1491824281 432 pgfqkkfhEKVIAALLQTMEDQgNQRVQAHAAAAL 466
Cdd:COG1413 108 --------PAAVPALLEALKDP-DWEVRRAAARAL 133
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
361-484 |
5.64e-08 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 52.71 E-value: 5.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 361 EHIMQMLQNPDWKYRHAGLMALSAIGEGchqqmegilnEIVNFVLLFLQDPHPRVRYAACNAVGQMATdfapgfqkkfhE 440
Cdd:COG1413 19 PALIAALADEDPDVRAAAARALGRLGDP----------RAVPALLEALKDPDPEVRAAAAEALGRIGD-----------P 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1491824281 441 KVIAALLQTMEDQgNQRVQAHAAAALINFTEDCPKSLLIPYLDN 484
Cdd:COG1413 78 EAVPALIAALKDE-DPEVRRAAAEALGRLGDPAAVPALLEALKD 120
|
|
| HEAT_2 |
pfam13646 |
HEAT repeats; This family includes multiple HEAT repeats. |
365-466 |
1.37e-07 |
|
HEAT repeats; This family includes multiple HEAT repeats.
Pssm-ID: 433376 [Multi-domain] Cd Length: 88 Bit Score: 50.03 E-value: 1.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 365 QMLQNPDWKYRHAGLMALSAIGEGchqqmegilnEIVNFVLLFLQDPHPRVRYAACNAVGQMATdfapgfqkkfhEKVIA 444
Cdd:pfam13646 7 ALLRDPDPEVRAAAIRALGRIGDP----------EAVPALLELLKDEDPAVRRAAAEALGKIGD-----------PEALP 65
|
90 100
....*....|....*....|..
gi 1491824281 445 ALLQTMEDQGNQRVQAHAAAAL 466
Cdd:pfam13646 66 ALLELLRDDDDDVVRAAAAEAL 87
|
|
| Importin_rep_5 |
pfam18816 |
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ... |
1005-1051 |
3.04e-06 |
|
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit and includes sequences not captured by pfam18808.
Pssm-ID: 465877 Cd Length: 52 Bit Score: 45.16 E-value: 3.04e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1491824281 1005 DKEEAVQTFNYLCDLIESNHPIVLGpnntNLPKIFSIIAEGEMHEAI 1051
Cdd:pfam18816 1 DEEAAPFAYRFLAELIEQNHPAVTS----QIPKVVDSVVQALEHKSL 43
|
|
| Vac14_Fab1_bd |
pfam12755 |
Vacuolar 14 Fab1-binding region; Vac14 is a scaffold for the Fab1 kinase complex, a complex ... |
374-422 |
1.46e-05 |
|
Vacuolar 14 Fab1-binding region; Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. This domain appears to be the one responsible for binding to Fab1. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.
Pssm-ID: 403838 Cd Length: 97 Bit Score: 44.51 E-value: 1.46e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1491824281 374 YRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAACNA 422
Cdd:pfam12755 2 ARKGGLIGLAATAIALGKDIAPYLDDIIPPVLACFSDQDSRVRYYACES 50
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
375-484 |
9.11e-05 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 43.46 E-value: 9.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1491824281 375 RHAGLMALSAIGEgchqqmegilNEIVNFVLLFLQDPHPRVRYAACNAVGQMAtdfapgfqkkfHEKVIAALLQTMEDQg 454
Cdd:COG1413 2 RRAAARALGRLGD----------PAAVPALIAALADEDPDVRAAAARALGRLG-----------DPRAVPALLEALKDP- 59
|
90 100 110
....*....|....*....|....*....|
gi 1491824281 455 NQRVQAHAAAALINFTEDCPKSLLIPYLDN 484
Cdd:COG1413 60 DPEVRAAAAEALGRIGDPEAVPALIAALKD 89
|
|
| HEAT |
pfam02985 |
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ... |
400-427 |
5.74e-04 |
|
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).
Pssm-ID: 460773 Cd Length: 31 Bit Score: 38.28 E-value: 5.74e-04
10 20
....*....|....*....|....*...
gi 1491824281 400 IVNFVLLFLQDPHPRVRYAACNAVGQMA 427
Cdd:pfam02985 1 LLPLLLKLLNDPSPEVREAAAEALGELA 28
|
|
| HEAT_EZ |
pfam13513 |
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ... |
919-966 |
6.48e-04 |
|
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 38.89 E-value: 6.48e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1491824281 919 PEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADSKTKENV 966
Cdd:pfam13513 1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAA 48
|
|
| HEAT_EZ |
pfam13513 |
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ... |
413-469 |
1.20e-03 |
|
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.
Pssm-ID: 463906 [Multi-domain] Cd Length: 55 Bit Score: 38.12 E-value: 1.20e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1491824281 413 PRVRYAACNAVGQMAtDFAPGFQKKFHEKVIAALLQTMEDqGNQRVQAHAAAALINF 469
Cdd:pfam13513 1 WRVREAAALALGSLA-EGGPDLLAPAVPELLPALLPLLND-DSDLVREAAAWALGRL 55
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
361-427 |
1.46e-03 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 40.00 E-value: 1.46e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1491824281 361 EHIMQMLQNPDWKYRHAGLMALSAIGEgchqqmegilNEIVNFVLLFLQDPHPRVRYAACNAVGQMA 427
Cdd:COG1413 81 PALIAALKDEDPEVRRAAAEALGRLGD----------PAAVPALLEALKDPDWEVRRAAARALGRLG 137
|
|
| IBN_N |
pfam03810 |
Importin-beta N-terminal domain; |
44-94 |
2.64e-03 |
|
Importin-beta N-terminal domain;
Pssm-ID: 397745 [Multi-domain] Cd Length: 72 Bit Score: 37.60 E-value: 2.64e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1491824281 44 FLLQAIRNTTAAEEARQMAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELL 94
Cdd:pfam03810 17 KLLQILSNSENPLEVRQLAALYLKNLITRHWEEEKNSLPPEEKEQIKNNLL 67
|
|
| HEAT |
pfam02985 |
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ... |
906-935 |
5.73e-03 |
|
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).
Pssm-ID: 460773 Cd Length: 31 Bit Score: 35.20 E-value: 5.73e-03
10 20 30
....*....|....*....|....*....|
gi 1491824281 906 FLRPMLQYVCDNSPEVRQAAAYGLGVMAQY 935
Cdd:pfam02985 1 LLPLLLKLLNDPSPEVREAAAEALGELAEV 30
|
|
| |
