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Conserved domains on  [gi|157384998|ref|NP_002325|]
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low-density lipoprotein receptor-related protein 4 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 505-545 4.18e-13

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 64.93  E-value: 4.18e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 157384998    505 VVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHR 545
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 270-304 4.97e-13

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 64.54  E-value: 4.97e-13
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 157384998  270 CTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENC 304
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
70-105 6.10e-13

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 64.58  E-value: 6.10e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 157384998    70 TCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDC 105
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 808-850 1.05e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.77  E-value: 1.05e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157384998    808 EVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMR 850
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Vgb super family cl26743
Streptogramin lyase [Defense mechanisms];
1332-1583 3.25e-12

Streptogramin lyase [Defense mechanisms];


The actual alignment was detected with superfamily member COG4257:

Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 68.89  E-value: 3.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1332 SCACPTGIQLKGDGktcdpspetYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSvDGKVYYTDVFLDVIRR 1411
Cdd:COG4257    15 PGSGPRDVAVDPDG---------AVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDP-DGNLWFTDNGNNRIGR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1412 ADLNGSNMETVIGRGLKTTD-GLAVDwVARNLYWTDTGRNTIeaSRLDGSCRKVLINNSLDE---PRAIAVFPrKGYLFW 1487
Cdd:COG4257    85 IDPKTGEITTFALPGGGSNPhGIAFD-PDGNLWFTDQGGNRI--GRLDPATGEVTEFPLPTGgagPYGIAVDP-DGNLWV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1488 TDWG--HIAKIERAnlDGSERKVLINTDLGWPNGLTLDYDTRrIYWVDA---HLDRIESADlnGKLRQVLVS-HVSHPFA 1561
Cdd:COG4257   161 TDFGanAIGRIDPD--TGTLTEYALPTPGAGPRGLAVDPDGN-LWVADTgsgRIGRFDPKT--GTVTEYPLPgGGARPYG 235

                         250       260
                  ....*....|....*....|...
gi 157384998 1562 LT-QQDRWIYWTDWQTKSIQRVD 1583
Cdd:COG4257   236 VAvDGDGRVWFAESGANRIVRFD 258
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 590-632 5.46e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.85  E-value: 5.46e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157384998    590 RIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHR 632
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1179-1219 6.12e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 61.79  E-value: 6.12e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 157384998  1179 GFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVD 1219
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 148-182 1.07e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 1.07e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 157384998  148 CSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENC 182
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1313-1348 1.09e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 60.72  E-value: 1.09e-11
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 157384998  1313 CGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC 1348
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 895-937 1.14e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.08  E-value: 1.14e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157384998    895 QVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKR 937
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 231-265 5.95e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 5.95e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 157384998  231 CRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNC 265
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 110-142 1.06e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 1.06e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 157384998  110 CEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQ 142
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 871-912 1.59e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 1.59e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998   871 GYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDY 912
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1085-1277 4.74e-10

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd05819:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 269  Bit Score: 62.34  E-value: 4.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1085 AIGVDPQeGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTD-----GLAVDAIGRkVYWTDTGTNRIEVGNLDGSMRK 1159
Cdd:cd05819    59 GVAVDSD-GNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVDSSGN-IYVADTGNHRIQKFDPDGEFLT 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1160 VL-----VWQNLDSPRAIVLYHEmGFMYWTDWGENA--KLERSG--MDGSDRAVLINNNLGWPNGLTVDkaSSQLLW-AD 1229
Cdd:cd05819   137 TFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNHRiqVFDPDGnfLTTFGSTGTGPGQFNYPTGIAVD--SDGNIYvAD 213

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 157384998 1230 AHTERIEAADLNGA------NRHTLVSPVQHPYGLTLLDS-YIYWTDWQTRSIHR 1277
Cdd:cd05819   214 SGNNRVQVFDPDGAgfggngNFLGSDGQFNRPSGLAVDSDgNLYVADTGNNRIQV 268
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 311-343 1.53e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 1.53e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 157384998    311 QCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDE 343
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 566-607 2.18e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.47  E-value: 2.18e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998   566 GTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDY 607
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
749-982 2.75e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 59.71  E-value: 2.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  749 RMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTN 828
Cdd:COG3391     1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  829 KLYWTDAGTDRIEVANTDgSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASpKIerAGMDASGRQVIISSNL-TWPNG 907
Cdd:COG3391    81 RLYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVATIPVgAGPHG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  908 LAIDYGSQRLYWADAGMKTIE--FAGLDGSKRKVL----IGSQlPHPFGLTLYGERIYWTDWQT-KSIQSADRLTGLDRE 980
Cdd:COG3391   157 IAVDPDGKRLYVANSGSNTVSviVSVIDTATGKVVatipVGGG-PVGVAVSPDGRRLYVANRGSnTSNGGSNTVSVIDLA 235


                  ..
gi 157384998  981 TL 982
Cdd:COG3391   236 TL 237
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1006-1043 3.70e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 53.79  E-value: 3.70e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 157384998  1006 CAMENGGCSHLCLrsPNPSGFSCTCPTGINLLSDGKTC 1043
Cdd:pfam14670    1 CSVNNGGCSHLCL--NTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 27-66 5.45e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 5.45e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 157384998   27 CGRSHFTCAVSalgecTCIPAQWQCDGDNDCGDHSDEDGC 66
Cdd:cd00112     1 CPPNEFRCANG-----RCIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 358-393 3.69e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.70  E-value: 3.69e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 157384998   358 CNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTC 393
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 702-729 8.90e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 49.93  E-value: 8.90e-08
                           10        20
                   ....*....|....*....|....*...
gi 157384998   702 CGDNNGGCTHLCLPSGQNYTCACPTGFR 729
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYE 28
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 460-502 1.63e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.44  E-value: 1.63e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157384998    460 YTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNV 502
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
395-434 2.87e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.87e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 157384998    395 DVNECAEEGYCSQG--CTNSEGAFQCWCETGYElrpDRRSCK 434
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYT---DGRNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1617-1648 9.13e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.07  E-value: 9.13e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 157384998  1617 CGVNNGGCTHLCFARASDFVCACPD----EPDSRPC 1648
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEgyelQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 633-673 1.12e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.05  E-value: 1.12e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157384998    633 KAVISQGLPHP--FAITVFEDSLYWTDWHTKSINSANkFTGKN 673
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN-LDGTN 42
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 505-545 4.18e-13

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 64.93  E-value: 4.18e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 157384998    505 VVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHR 545
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 270-304 4.97e-13

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 64.54  E-value: 4.97e-13
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 157384998  270 CTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENC 304
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
70-105 6.10e-13

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 64.58  E-value: 6.10e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 157384998    70 TCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDC 105
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 808-850 1.05e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.77  E-value: 1.05e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157384998    808 EVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMR 850
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1332-1583 3.25e-12

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 68.89  E-value: 3.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1332 SCACPTGIQLKGDGktcdpspetYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSvDGKVYYTDVFLDVIRR 1411
Cdd:COG4257    15 PGSGPRDVAVDPDG---------AVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDP-DGNLWFTDNGNNRIGR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1412 ADLNGSNMETVIGRGLKTTD-GLAVDwVARNLYWTDTGRNTIeaSRLDGSCRKVLINNSLDE---PRAIAVFPrKGYLFW 1487
Cdd:COG4257    85 IDPKTGEITTFALPGGGSNPhGIAFD-PDGNLWFTDQGGNRI--GRLDPATGEVTEFPLPTGgagPYGIAVDP-DGNLWV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1488 TDWG--HIAKIERAnlDGSERKVLINTDLGWPNGLTLDYDTRrIYWVDA---HLDRIESADlnGKLRQVLVS-HVSHPFA 1561
Cdd:COG4257   161 TDFGanAIGRIDPD--TGTLTEYALPTPGAGPRGLAVDPDGN-LWVADTgsgRIGRFDPKT--GTVTEYPLPgGGARPYG 235

                         250       260
                  ....*....|....*....|...
gi 157384998 1562 LT-QQDRWIYWTDWQTKSIQRVD 1583
Cdd:COG4257   236 VAvDGDGRVWFAESGANRIVRFD 258
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 71-105 5.17e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 5.17e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 157384998   71 CSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDC 105
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 590-632 5.46e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.85  E-value: 5.46e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157384998    590 RIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHR 632
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1179-1219 6.12e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 61.79  E-value: 6.12e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 157384998  1179 GFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVD 1219
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1483-1524 7.66e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 61.41  E-value: 7.66e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998  1483 GYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDY 1524
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 148-182 1.07e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 1.07e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 157384998  148 CSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENC 182
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1507-1547 1.07e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.08  E-value: 1.07e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 157384998   1507 KVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGK 1547
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1313-1348 1.09e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 60.72  E-value: 1.09e-11
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 157384998  1313 CGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC 1348
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 895-937 1.14e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.08  E-value: 1.14e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157384998    895 QVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKR 937
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
146-182 1.61e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 60.34  E-value: 1.61e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 157384998   146 RKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENC 182
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 270-301 4.63e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 59.18  E-value: 4.63e-11
                            10        20        30
                    ....*....|....*....|....*....|..
gi 157384998    270 CTAEQFRCHSGRCVRLSWRCDGEDDCADNSDE 301
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 70-102 5.79e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.80  E-value: 5.79e-11
                            10        20        30
                    ....*....|....*....|....*....|...
gi 157384998     70 TCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDE 102
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 231-265 5.95e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 5.95e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 157384998  231 CRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNC 265
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
230-265 1.02e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 1.02e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 157384998   230 PCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNC 265
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 110-142 1.06e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 1.06e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 157384998  110 CEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQ 142
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 109-141 1.06e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.03  E-value: 1.06e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 157384998    109 ECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDE 141
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
270-304 1.52e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 1.52e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 157384998   270 CTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENC 304
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 871-912 1.59e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 1.59e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998   871 GYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDY 912
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 147-179 2.99e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.87  E-value: 2.99e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 157384998    147 KCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDE 179
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1085-1277 4.74e-10

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 62.34  E-value: 4.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1085 AIGVDPQeGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTD-----GLAVDAIGRkVYWTDTGTNRIEVGNLDGSMRK 1159
Cdd:cd05819    59 GVAVDSD-GNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVDSSGN-IYVADTGNHRIQKFDPDGEFLT 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1160 VL-----VWQNLDSPRAIVLYHEmGFMYWTDWGENA--KLERSG--MDGSDRAVLINNNLGWPNGLTVDkaSSQLLW-AD 1229
Cdd:cd05819   137 TFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNHRiqVFDPDGnfLTTFGSTGTGPGQFNYPTGIAVD--SDGNIYvAD 213

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 157384998 1230 AHTERIEAADLNGA------NRHTLVSPVQHPYGLTLLDS-YIYWTDWQTRSIHR 1277
Cdd:cd05819   214 SGNNRVQVFDPDGAgfggngNFLGSDGQFNRPSGLAVDSDgNLYVADTGNNRIQV 268
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 780-969 7.18e-10

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 61.83  E-value: 7.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  780 WDsRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSlESPAGLAID-----WVTN---KLYWTDAGTDRIEVANTDGSMRt 851
Cdd:COG3386    15 WD-PDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDpdgrlLVADhgrGLVRFDPADGEVTVLADEYGKP- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  852 vliwenLDRPRDIVVEPMGGYmYWTDwgaSPKIERAG----MDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTI 927
Cdd:COG3386    92 ------LNRPNDGVVDPDGRL-YFTD---MGEYLPTGalyrVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRI 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 157384998  928 ---EFAGlDG--SKRKVLIGSQLPHPF--GLTLYGE-RIYWTDWQTKSIQ 969
Cdd:COG3386   162 yrfDLDA-DGtlGNRRVFADLPDGPGGpdGLAVDADgNLWVALWGGGGVV 210
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 231-262 7.57e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 7.57e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 157384998    231 CRSGEFMCDSGLCINAGWRCDGDADCDDQSDE 262
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1118-1158 1.24e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 1.24e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 157384998   1118 IITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMR 1158
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 311-343 1.53e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 1.53e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 157384998    311 QCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDE 343
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 566-607 2.18e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.47  E-value: 2.18e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998   566 GTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDY 607
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 312-349 2.51e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 2.51e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 157384998  312 CALDQFLCWNGRCIGQRKLCNGVNDCGDNSDEspqQNC 349
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE---ENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 523-563 2.60e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.09  E-value: 2.60e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998   523 DKLYWTDSGTS-RIEVANLDGAHRKVLLWQNLEKPRAIALHP 563
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
749-982 2.75e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 59.71  E-value: 2.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  749 RMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTN 828
Cdd:COG3391     1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  829 KLYWTDAGTDRIEVANTDgSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASpKIerAGMDASGRQVIISSNL-TWPNG 907
Cdd:COG3391    81 RLYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVATIPVgAGPHG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  908 LAIDYGSQRLYWADAGMKTIE--FAGLDGSKRKVL----IGSQlPHPFGLTLYGERIYWTDWQT-KSIQSADRLTGLDRE 980
Cdd:COG3391   157 IAVDPDGKRLYVANSGSNTVSviVSVIDTATGKVVatipVGGG-PVGVAVSPDGRRLYVANRGSnTSNGGSNTVSVIDLA 235


                  ..
gi 157384998  981 TL 982
Cdd:COG3391   236 TL 237
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
110-142 2.97e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.79  E-value: 2.97e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 157384998   110 CEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQ 142
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1006-1043 3.70e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 53.79  E-value: 3.70e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 157384998  1006 CAMENGGCSHLCLrsPNPSGFSCTCPTGINLLSDGKTC 1043
Cdd:pfam14670    1 CSVNNGGCSHLCL--NTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 546-589 4.74e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.37  E-value: 4.74e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 157384998    546 KVLLWQNLEKPRAIALHPMEGTIYWTDWGnTPRIEASSMDGSGR 589
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 27-66 5.45e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 5.45e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 157384998   27 CGRSHFTCAVSalgecTCIPAQWQCDGDNDCGDHSDEDGC 66
Cdd:cd00112     1 CPPNEFRCANG-----RCIPSSWVCDGEDDCGDGSDEENC 35
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 471-622 6.44e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 58.87  E-value: 6.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  471 IALDFHHRrelVFWSDVTLDRILRANLNGSNVEEVVSTG-----LESPGGLAVDwVHDKLYWTDSGTSRIEVANLDGahR 545
Cdd:cd05819   107 IAVDSSGN---IYVADTGNHRIQKFDPDGEFLTTFGSGGsgpgqFNGPTGVAVD-SDGNIYVADTGNHRIQVFDPDG--N 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  546 KVLLW-------QNLEKPRAIALHPmEGTIYWTDWGNTpRI-----EASSMDGSGRRIIADTHLFWPNGLTIDYAGrRMY 613
Cdd:cd05819   181 FLTTFgstgtgpGQFNYPTGIAVDS-DGNIYVADSGNN-RVqvfdpDGAGFGGNGNFLGSDGQFNRPSGLAVDSDG-NLY 257


                  ....*....
gi 157384998  614 WVDAKHHVI 622
Cdd:cd05819   258 VADTGNNRI 266
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1383-1582 1.98e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 57.71  E-value: 1.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1383 ELNNVISLDYDSvDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTD-----GLAVDwVARNLYWTDTGRNTIEASRL 1457
Cdd:cd05819    53 QFNEPAGVAVDS-DGNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVD-SSGNIYVADTGNHRIQKFDP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1458 DGSCRKVL-----INNSLDEPRAIAVFPrKGYLFWTDWGHiAKIERANLDGSERKVL-----INTDLGWPNGLTLDYDTr 1527
Cdd:cd05819   131 DGEFLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADTGN-HRIQVFDPDGNFLTTFgstgtGPGQFNYPTGIAVDSDG- 207

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157384998 1528 RIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQ-------QDRWIYWTDWQTKSIQRV 1582
Cdd:cd05819   208 NIYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQFNRpsglavdSDGNLYVADTGNNRIQVF 269
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 610-650 3.09e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 3.09e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998   610 RRMYWVDAK-HHVIERANLDGSHRKAVISQGLPHPFAITVFE 650
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 358-393 3.69e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.70  E-value: 3.69e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 157384998   358 CNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTC 393
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 774-927 5.72e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 56.17  E-value: 5.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  774 SAVALDwdsRDDHVYWTDVSTDTISraKWDGTGQEVVV-------DTSLESPAGLAIDwVTNKLYWTDAGTDRIEVANTD 846
Cdd:cd05819   105 RGIAVD---SSGNIYVADTGNHRIQ--KFDPDGEFLTTfgsggsgPGQFNGPTGVAVD-SDGNIYVADTGNHRIQVFDPD 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  847 GsmRTVLIW-------ENLDRPRDIVVEPmGGYMYWTDWGASpKIER-----AGMDASGRQVIISSNLTWPNGLAIDyGS 914
Cdd:cd05819   179 G--NFLTTFgstgtgpGQFNYPTGIAVDS-DGNIYVADSGNN-RVQVfdpdgAGFGGNGNFLGSDGQFNRPSGLAVD-SD 253

                         170
                  ....*....|...
gi 157384998  915 QRLYWADAGMKTI 927
Cdd:cd05819   254 GNLYVADTGNNRI 266
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 702-729 8.90e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 49.93  E-value: 8.90e-08
                           10        20
                   ....*....|....*....|....*...
gi 157384998   702 CGDNNGGCTHLCLPSGQNYTCACPTGFR 729
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYE 28
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1038-1239 2.67e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 53.54  E-value: 2.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1038 SDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHED 1117
Cdd:COG3391    25 VAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1118 IITTGlQTTDGLAVDAIGRKVYWTDTGTNRIEVgnLDGSMRKVL-VWQNLDSPRAIVLYHEMGFMYWTDWGEN--AKLEr 1194
Cdd:COG3391   105 TIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGSNtvSVIV- 180

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 157384998 1195 SGMDGSDRAVLINNNLG-WPNGLTVDKASSQLLWADAHTERIEAAD 1239
Cdd:COG3391   181 SVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNTSNGGS 226
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 27-63 2.76e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.40  E-value: 2.76e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 157384998     27 CGRSHFTCAVSalgecTCIPAQWQCDGDNDCGDHSDE 63
Cdd:smart00192    2 CPPGEFQCDNG-----RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
27-66 2.82e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 2.82e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 157384998    27 CGRSHFTCAVSalgecTCIPAQWQCDGDNDCGDHSDEDGC 66
Cdd:pfam00057    3 CSPNEFQCGSG-----ECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 828-868 4.45e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.92  E-value: 4.45e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998   828 NKLYWTDAGTD-RIEVANTDGSMRTVLIWENLDRPRDIVVEP 868
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1136-1176 8.66e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.15  E-value: 8.66e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998  1136 RKVYWTDTGT-NRIEVGNLDGSMRKVLVWQNLDSPRAIVLYH 1176
Cdd:pfam00058    1 GRLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 852-894 1.25e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 1.25e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157384998    852 VLIWENLDRPRDIVVEPMGGYMYWTDWGaSPKIERAGMDASGR 894
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 460-502 1.63e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.44  E-value: 1.63e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157384998    460 YTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNV 502
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
311-349 2.44e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 45.70  E-value: 2.44e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 157384998   311 QCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDEspqQNC 349
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE---ENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 766-806 1.59e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.74  E-value: 1.59e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 157384998    766 VIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTG 806
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 785-825 2.79e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.92  E-value: 2.79e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998   785 DHVYWTDVSTD-TISRAKWDGTGQEVVVDTSLESPAGLAIDW 825
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
395-434 2.87e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.87e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 157384998    395 DVNECAEEGYCSQG--CTNSEGAFQCWCETGYElrpDRRSCK 434
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYT---DGRNCE 39
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 915-954 7.03e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.76  E-value: 7.03e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 157384998   915 QRLYWADAGMK-TIEFAGLDGSKRKVLIGSQLPHPFGLTLY 954
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1159-1202 8.85e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.43  E-value: 8.85e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 157384998   1159 KVLVWQNLDSPRAIVLYHEMGFMYWTDWGeNAKLERSGMDGSDR 1202
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1617-1648 9.13e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.07  E-value: 9.13e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 157384998  1617 CGVNNGGCTHLCFARASDFVCACPD----EPDSRPC 1648
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEgyelQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 633-673 1.12e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.05  E-value: 1.12e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157384998    633 KAVISQGLPHP--FAITVFEDSLYWTDWHTKSINSANkFTGKN 673
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN-LDGTN 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 399-433 1.78e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.30  E-value: 1.78e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 157384998   399 CAEE-GYCSQGCTNSEGAFQCWCETGYELRPDRRSC 433
Cdd:pfam14670    1 CSVNnGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 395-427 1.81e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.81e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 157384998  395 DVNECAEEGYCSQG--CTNSEGAFQCWCETGYELR 427
Cdd:cd00054     1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGYTGR 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 480-520 7.02e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.07  E-value: 7.02e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998   480 ELVFWSDVTLD-RILRANLNGSNVEEVVSTGLESPGGLAVDW 520
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 505-545 4.18e-13

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 64.93  E-value: 4.18e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 157384998    505 VVSTGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHR 545
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 270-304 4.97e-13

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 64.54  E-value: 4.97e-13
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 157384998  270 CTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENC 304
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
70-105 6.10e-13

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 64.58  E-value: 6.10e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 157384998    70 TCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDC 105
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 808-850 1.05e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 63.77  E-value: 1.05e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157384998    808 EVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMR 850
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1332-1583 3.25e-12

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 68.89  E-value: 3.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1332 SCACPTGIQLKGDGktcdpspetYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSvDGKVYYTDVFLDVIRR 1411
Cdd:COG4257    15 PGSGPRDVAVDPDG---------AVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDP-DGNLWFTDNGNNRIGR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1412 ADLNGSNMETVIGRGLKTTD-GLAVDwVARNLYWTDTGRNTIeaSRLDGSCRKVLINNSLDE---PRAIAVFPrKGYLFW 1487
Cdd:COG4257    85 IDPKTGEITTFALPGGGSNPhGIAFD-PDGNLWFTDQGGNRI--GRLDPATGEVTEFPLPTGgagPYGIAVDP-DGNLWV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1488 TDWG--HIAKIERAnlDGSERKVLINTDLGWPNGLTLDYDTRrIYWVDA---HLDRIESADlnGKLRQVLVS-HVSHPFA 1561
Cdd:COG4257   161 TDFGanAIGRIDPD--TGTLTEYALPTPGAGPRGLAVDPDGN-LWVADTgsgRIGRFDPKT--GTVTEYPLPgGGARPYG 235

                         250       260
                  ....*....|....*....|...
gi 157384998 1562 LT-QQDRWIYWTDWQTKSIQRVD 1583
Cdd:COG4257   236 VAvDGDGRVWFAESGANRIVRFD 258
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 71-105 5.17e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 61.84  E-value: 5.17e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 157384998   71 CSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDC 105
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 590-632 5.46e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.85  E-value: 5.46e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157384998    590 RIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHR 632
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1179-1219 6.12e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 61.79  E-value: 6.12e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 157384998  1179 GFMYWTDWGENAKLERSGMDGSDRAVLINNNLGWPNGLTVD 1219
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1483-1524 7.66e-12

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 61.41  E-value: 7.66e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998  1483 GYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDY 1524
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 148-182 1.07e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 1.07e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 157384998  148 CSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENC 182
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1507-1547 1.07e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.08  E-value: 1.07e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 157384998   1507 KVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGK 1547
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1313-1348 1.09e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 60.72  E-value: 1.09e-11
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 157384998  1313 CGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTC 1348
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 895-937 1.14e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.08  E-value: 1.14e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157384998    895 QVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKR 937
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
146-182 1.61e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 60.34  E-value: 1.61e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 157384998   146 RKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENC 182
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 270-301 4.63e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 59.18  E-value: 4.63e-11
                            10        20        30
                    ....*....|....*....|....*....|..
gi 157384998    270 CTAEQFRCHSGRCVRLSWRCDGEDDCADNSDE 301
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 70-102 5.79e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.80  E-value: 5.79e-11
                            10        20        30
                    ....*....|....*....|....*....|...
gi 157384998     70 TCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDE 102
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 231-265 5.95e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 58.76  E-value: 5.95e-11
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 157384998  231 CRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNC 265
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
230-265 1.02e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.03  E-value: 1.02e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 157384998   230 PCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNC 265
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 110-142 1.06e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 1.06e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 157384998  110 CEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQ 142
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 109-141 1.06e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.03  E-value: 1.06e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 157384998    109 ECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDE 141
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
270-304 1.52e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 57.64  E-value: 1.52e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 157384998   270 CTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENC 304
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 871-912 1.59e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 1.59e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998   871 GYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDY 912
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 147-179 2.99e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.87  E-value: 2.99e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 157384998    147 KCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDE 179
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1085-1277 4.74e-10

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 62.34  E-value: 4.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1085 AIGVDPQeGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTD-----GLAVDAIGRkVYWTDTGTNRIEVGNLDGSMRK 1159
Cdd:cd05819    59 GVAVDSD-GNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVDSSGN-IYVADTGNHRIQKFDPDGEFLT 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1160 VL-----VWQNLDSPRAIVLYHEmGFMYWTDWGENA--KLERSG--MDGSDRAVLINNNLGWPNGLTVDkaSSQLLW-AD 1229
Cdd:cd05819   137 TFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNHRiqVFDPDGnfLTTFGSTGTGPGQFNYPTGIAVD--SDGNIYvAD 213

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 157384998 1230 AHTERIEAADLNGA------NRHTLVSPVQHPYGLTLLDS-YIYWTDWQTRSIHR 1277
Cdd:cd05819   214 SGNNRVQVFDPDGAgfggngNFLGSDGQFNRPSGLAVDSDgNLYVADTGNNRIQV 268
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 780-969 7.18e-10

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 61.83  E-value: 7.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  780 WDsRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSlESPAGLAID-----WVTN---KLYWTDAGTDRIEVANTDGSMRt 851
Cdd:COG3386    15 WD-PDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDpdgrlLVADhgrGLVRFDPADGEVTVLADEYGKP- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  852 vliwenLDRPRDIVVEPMGGYmYWTDwgaSPKIERAG----MDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTI 927
Cdd:COG3386    92 ------LNRPNDGVVDPDGRL-YFTD---MGEYLPTGalyrVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRI 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 157384998  928 ---EFAGlDG--SKRKVLIGSQLPHPF--GLTLYGE-RIYWTDWQTKSIQ 969
Cdd:COG3386   162 yrfDLDA-DGtlGNRRVFADLPDGPGGpdGLAVDADgNLWVALWGGGGVV 210
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 231-262 7.57e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.72  E-value: 7.57e-10
                            10        20        30
                    ....*....|....*....|....*....|..
gi 157384998    231 CRSGEFMCDSGLCINAGWRCDGDADCDDQSDE 262
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1463-1506 8.14e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.69  E-value: 8.14e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 157384998   1463 KVLINNSLDEPRAIAVFPRKGYLFWTDWGHiAKIERANLDGSER 1506
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1420-1460 1.11e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 1.11e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 157384998   1420 ETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGS 1460
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1118-1158 1.24e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 55.30  E-value: 1.24e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 157384998   1118 IITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMR 1158
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
756-923 1.40e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 60.48  E-value: 1.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  756 SFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISraKWD-GTGQEVVVDTSLESPAGLAIDWVTNKLYWTD 834
Cdd:COG3391    51 GGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVS--VIDlATGKVVATIPVGGGPRGLAVDPDGGRLYVAD 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  835 AGTDRIEVANTDgSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGaSPKIER--AGMDASGRQVI--ISSNLTwPNGLAI 910
Cdd:COG3391   129 SGNGRVSVIDTA-TGKVVATIPVGAGPHGIAVDPDGKRLYVANSG-SNTVSVivSVIDTATGKVVatIPVGGG-PVGVAV 205

                         170
                  ....*....|...
gi 157384998  911 DYGSQRLYWADAG 923
Cdd:COG3391   206 SPDGRRLYVANRG 218
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 311-343 1.53e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 1.53e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 157384998    311 QCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDE 343
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 566-607 2.18e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.47  E-value: 2.18e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998   566 GTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGLTIDY 607
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 312-349 2.51e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 54.13  E-value: 2.51e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 157384998  312 CALDQFLCWNGRCIGQRKLCNGVNDCGDNSDEspqQNC 349
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE---ENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 523-563 2.60e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 54.09  E-value: 2.60e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998   523 DKLYWTDSGTS-RIEVANLDGAHRKVLLWQNLEKPRAIALHP 563
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
482-636 2.65e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 59.71  E-value: 2.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  482 VFWSDVTLDRILRANLNGSNVEEVVSTGlESPGGLAVDWVHDKLYWTDSGTSRIEVanLDGAHRKVLL-WQNLEKPRAIA 560
Cdd:COG3391    82 LYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVAtIPVGAGPHGIA 158

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157384998  561 LHPMEGTIYWTDWGNtPRIEA--SSMDGSGRRIIADTHL-FWPNGLTIDYAGRRMYWVDAKHHvieRANLdGSHRKAVI 636
Cdd:COG3391   159 VDPDGKRLYVANSGS-NTVSVivSVIDTATGKVVATIPVgGGPVGVAVSPDGRRLYVANRGSN---TSNG-GSNTVSVI 232
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
749-982 2.75e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 59.71  E-value: 2.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  749 RMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTN 828
Cdd:COG3391     1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  829 KLYWTDAGTDRIEVANTDgSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASpKIerAGMDASGRQVIISSNL-TWPNG 907
Cdd:COG3391    81 RLYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVATIPVgAGPHG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  908 LAIDYGSQRLYWADAGMKTIE--FAGLDGSKRKVL----IGSQlPHPFGLTLYGERIYWTDWQT-KSIQSADRLTGLDRE 980
Cdd:COG3391   157 IAVDPDGKRLYVANSGSNTVSviVSVIDTATGKVVatipVGGG-PVGVAVSPDGRRLYVANRGSnTSNGGSNTVSVIDLA 235


                  ..
gi 157384998  981 TL 982
Cdd:COG3391   236 TL 237
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
110-142 2.97e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.79  E-value: 2.97e-09
                           10        20        30
                   ....*....|....*....|....*....|...
gi 157384998   110 CEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQ 142
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1006-1043 3.70e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 53.79  E-value: 3.70e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 157384998  1006 CAMENGGCSHLCLrsPNPSGFSCTCPTGINLLSDGKTC 1043
Cdd:pfam14670    1 CSVNNGGCSHLCL--NTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 546-589 4.74e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 53.37  E-value: 4.74e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 157384998    546 KVLLWQNLEKPRAIALHPMEGTIYWTDWGnTPRIEASSMDGSGR 589
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 27-66 5.45e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 5.45e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 157384998   27 CGRSHFTCAVSalgecTCIPAQWQCDGDNDCGDHSDEDGC 66
Cdd:cd00112     1 CPPNEFRCANG-----RCIPSSWVCDGEDDCGDGSDEENC 35
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 471-622 6.44e-09

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 58.87  E-value: 6.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  471 IALDFHHRrelVFWSDVTLDRILRANLNGSNVEEVVSTG-----LESPGGLAVDwVHDKLYWTDSGTSRIEVANLDGahR 545
Cdd:cd05819   107 IAVDSSGN---IYVADTGNHRIQKFDPDGEFLTTFGSGGsgpgqFNGPTGVAVD-SDGNIYVADTGNHRIQVFDPDG--N 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  546 KVLLW-------QNLEKPRAIALHPmEGTIYWTDWGNTpRI-----EASSMDGSGRRIIADTHLFWPNGLTIDYAGrRMY 613
Cdd:cd05819   181 FLTTFgstgtgpGQFNYPTGIAVDS-DGNIYVADSGNN-RVqvfdpDGAGFGGNGNFLGSDGQFNRPSGLAVDSDG-NLY 257


                  ....*....
gi 157384998  614 WVDAKHHVI 622
Cdd:cd05819   258 VADTGNNRI 266
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1383-1582 1.98e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 57.71  E-value: 1.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1383 ELNNVISLDYDSvDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTD-----GLAVDwVARNLYWTDTGRNTIEASRL 1457
Cdd:cd05819    53 QFNEPAGVAVDS-DGNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVD-SSGNIYVADTGNHRIQKFDP 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1458 DGSCRKVL-----INNSLDEPRAIAVFPrKGYLFWTDWGHiAKIERANLDGSERKVL-----INTDLGWPNGLTLDYDTr 1527
Cdd:cd05819   131 DGEFLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADTGN-HRIQVFDPDGNFLTTFgstgtGPGQFNYPTGIAVDSDG- 207

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157384998 1528 RIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQ-------QDRWIYWTDWQTKSIQRV 1582
Cdd:cd05819   208 NIYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQFNRpsglavdSDGNLYVADTGNNRIQVF 269
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 610-650 3.09e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 3.09e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998   610 RRMYWVDAK-HHVIERANLDGSHRKAVISQGLPHPFAITVFE 650
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 358-393 3.69e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.70  E-value: 3.69e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 157384998   358 CNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTC 393
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 774-927 5.72e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 56.17  E-value: 5.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  774 SAVALDwdsRDDHVYWTDVSTDTISraKWDGTGQEVVV-------DTSLESPAGLAIDwVTNKLYWTDAGTDRIEVANTD 846
Cdd:cd05819   105 RGIAVD---SSGNIYVADTGNHRIQ--KFDPDGEFLTTfgsggsgPGQFNGPTGVAVD-SDGNIYVADTGNHRIQVFDPD 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  847 GsmRTVLIW-------ENLDRPRDIVVEPmGGYMYWTDWGASpKIER-----AGMDASGRQVIISSNLTWPNGLAIDyGS 914
Cdd:cd05819   179 G--NFLTTFgstgtgpGQFNYPTGIAVDS-DGNIYVADSGNN-RVQVfdpdgAGFGGNGNFLGSDGQFNRPSGLAVD-SD 253

                         170
                  ....*....|...
gi 157384998  915 QRLYWADAGMKTI 927
Cdd:cd05819   254 GNLYVADTGNNRI 266
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1204-1245 6.04e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.29  E-value: 6.04e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 157384998   1204 VLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANR 1245
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 702-729 8.90e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 49.93  E-value: 8.90e-08
                           10        20
                   ....*....|....*....|....*...
gi 157384998   702 CGDNNGGCTHLCLPSGQNYTCACPTGFR 729
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYE 28
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 503-657 1.82e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 54.52  E-value: 1.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  503 EEVVSTGLESPGGLAVDwVHDKLYWTDSGTSRIEVanLDGAHRKVLLW-----QNLEKPRAIALHPmEGTIYWTDWGNTp 577
Cdd:cd14962     4 EERPKEALTRPYGVAAD-GRGRIYVADTGRGAVFV--FDLPNGKVFVIgnagpNRFVSPIGVAIDA-NGNLYVSDAELG- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  578 RIEASSMDGSGRRIIADTHLFW-PNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQG-----LPHPFAITVF-E 650
Cdd:cd14962    79 KVFVFDRDGKFLRAIGAGALFKrPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIGKRGsgpgeFNLPTDLAVDrD 158


                  ....*..
gi 157384998  651 DSLYWTD 657
Cdd:cd14962   159 GNLYVTD 165
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1038-1239 2.67e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 53.54  E-value: 2.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1038 SDGKTCSPGMNSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDGSQHED 1117
Cdd:COG3391    25 VAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1118 IITTGlQTTDGLAVDAIGRKVYWTDTGTNRIEVgnLDGSMRKVL-VWQNLDSPRAIVLYHEMGFMYWTDWGEN--AKLEr 1194
Cdd:COG3391   105 TIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSGSNtvSVIV- 180

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 157384998 1195 SGMDGSDRAVLINNNLG-WPNGLTVDKASSQLLWADAHTERIEAAD 1239
Cdd:COG3391   181 SVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNTSNGGS 226
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 27-63 2.76e-07

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 48.40  E-value: 2.76e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 157384998     27 CGRSHFTCAVSalgecTCIPAQWQCDGDNDCGDHSDE 63
Cdd:smart00192    2 CPPGEFQCDNG-----RCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
27-66 2.82e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.40  E-value: 2.82e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 157384998    27 CGRSHFTCAVSalgecTCIPAQWQCDGDNDCGDHSDEDGC 66
Cdd:pfam00057    3 CSPNEFQCGSG-----ECIPRSWVCDGDPDCGDGSDEENC 37
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 502-658 3.50e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 53.83  E-value: 3.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  502 VEEVVSTGLESPGGLAVDwvHDKLYWTDSGTSRIEVANLDGahrKVLLW--------QNLEKPRAIALHPmEGTIYWTDW 573
Cdd:cd14963    93 PEKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEG---KLLLEfgkpgsepGELSYPNGIAVDE-DGNIYVADS 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  574 GNTpRIEASSMDGSGRRIIA-----DTHLFWPNGLTIDYAGrRMYWVDAKHHVIERANLDGSHRKAVISQG-----LPHP 643
Cdd:cd14963   167 GNG-RIQVFDKNGKFIKELNgspdgKSGFVNPRGIAVDPDG-NLYVVDNLSHRVYVFDEQGKELFTFGGRGkddgqFNLP 244

                         170
                  ....*....|....*.
gi 157384998  644 FAITVFEDS-LYWTDW 658
Cdd:cd14963   245 NGLFIDDDGrLYVTDR 260
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 828-868 4.45e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.92  E-value: 4.45e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998   828 NKLYWTDAGTD-RIEVANTDGSMRTVLIWENLDRPRDIVVEP 868
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1136-1176 8.66e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.15  E-value: 8.66e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998  1136 RKVYWTDTGT-NRIEVGNLDGSMRKVLVWQNLDSPRAIVLYH 1176
Cdd:pfam00058    1 GRLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1079-1155 1.06e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 52.20  E-value: 1.06e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157384998 1079 TMKNTIAIGVDPQeGKVYWSDSTLHRISRANLDGsQHEDIITTGLQTTD--GLAVDAIGRKVYWTDTGTNRIEVGNLDG 1155
Cdd:cd14962    55 RFVSPIGVAIDAN-GNLYVSDAELGKVFVFDRDG-KFLRAIGAGALFKRptGIAVDPAGKRLYVVDTLAHKVKVFDLDG 131
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1440-1480 1.07e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.77  E-value: 1.07e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998  1440 RNLYWTDTG-RNTIEASRLDGSCRKVLINNSLDEPRAIAVFP 1480
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 852-894 1.25e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 1.25e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157384998    852 VLIWENLDRPRDIVVEPMGGYMYWTDWGaSPKIERAGMDASGR 894
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1085-1115 1.30e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 1.30e-06
                            10        20        30
                    ....*....|....*....|....*....|.
gi 157384998   1085 AIGVDPQEGKVYWSDSTLHRISRANLDGSQH 1115
Cdd:smart00135   13 GLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 477-630 1.40e-06

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 51.82  E-value: 1.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  477 HRRELVFWSDVTLDRILRANLNGSNVEEVVSTGlESPGGLAVDWvHDKLYWTDSGtSRIEVANLDGAHRKVLLwQNLEKP 556
Cdd:COG3386    16 DPDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDP-DGRLLVADHG-RGLVRFDPADGEVTVLA-DEYGKP 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  557 RA----IALHPmEGTIYWTDWGNTP------RIEAssmDGSGRRIIADthLFWPNGLTIDYAGRRMYWVDAKHHVIERAN 626
Cdd:COG3386    92 LNrpndGVVDP-DGRLYFTDMGEYLptgalyRVDP---DGSLRVLADG--LTFPNGIAFSPDGRTLYVADTGAGRIYRFD 165


                  ....
gi 157384998  627 LDGS 630
Cdd:COG3386   166 LDAD 169
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 511-631 1.47e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 51.90  E-value: 1.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  511 ESPGGLAVDWVHDkLYWTDSGTSRIEVANLDGAHRKVlLWQ------NLEKPRAIALHPmEGTIYWTD-WGNtpRIEASS 583
Cdd:cd14956    13 KDPRGIAVDADDN-VYVADARNGRIQVFDKDGTFLRR-FGTtgdgpgQFGRPRGLAVDK-DGWLYVADyWGD--RIQVFT 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 157384998  584 MDGSGRRII-----ADTHLFWPNGLTIDYAGRrmYWV-DAKHHVIERANLDGSH 631
Cdd:cd14956    88 LTGELQTIGgssgsGPGQFNAPRGVAVDADGN--LYVaDFGNQRIQKFDPDGSF 139
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 482-657 1.59e-06

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 51.44  E-value: 1.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  482 VFWSDVTLDRILR--AnlnGSNVEEVVS-TGLESPGGLAVDwVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRA 558
Cdd:cd14952    23 VYVADSGNNRVLKlaA---GSTTQTVLPfTGLYQPQGVAVD-AAGTVYVTDFGNNRVLKLAAGSTTQTVLPFTGLNDPTG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  559 IALHPmEGTIYWTDWGNTpRIeASSMDGSGRRIIAD-THLFWPNGLTIDYAGrRMYWVDAKHHVIERANLdGSHRKAVIS 637
Cdd:cd14952    99 VAVDA-AGNVYVADTGNN-RV-LKLAAGSNTQTVLPfTGLSNPDGVAVDGAG-NVYVTDTGNNRVLKLAA-GSTTQTVLP 173

                         170       180
                  ....*....|....*....|..
gi 157384998  638 -QGLPHPFAITV-FEDSLYWTD 657
Cdd:cd14952   174 fTGLNSPSGVAVdTAGNVYVTD 195
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 460-502 1.63e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.44  E-value: 1.63e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157384998    460 YTLLLNNLENAIALDFHHRRELVFWSDVTLDRILRANLNGSNV 502
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 471-688 2.08e-06

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 51.55  E-value: 2.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  471 IALDFHHRrelVFWSDVTLDRILRANLNGSNVEEVVSTG-----LESPGGLAVDwVHDKLYWTDSGTSRIEVANLDGAHR 545
Cdd:cd05819    13 IAVDSSGN---IYVADTGNNRIQVFDPDGNFITSFGSFGsgdgqFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  546 KVLL-----WQNLEKPRAIALHPmEGTIYWTDWGNTpRIEASSMDGSGRRII-----ADTHLFWPNGLTIDYAGrRMYWV 615
Cdd:cd05819    89 ASFGgsgdgDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVDSDG-NIYVA 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  616 DAKHHVIERANLDGSHRKAVISQGLP-----HPFAITVFED-SLYWTDWHTKSInsaNKFTGKNQEIIRN--------KL 681
Cdd:cd05819   166 DTGNHRIQVFDPDGNFLTTFGSTGTGpgqfnYPTGIAVDSDgNIYVADSGNNRV---QVFDPDGAGFGGNgnflgsdgQF 242


                  ....*..
gi 157384998  682 HFPMDIH 688
Cdd:cd05819   243 NRPSGLA 249
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
311-349 2.44e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 45.70  E-value: 2.44e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 157384998   311 QCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDEspqQNC 349
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE---ENC 37
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 775-922 2.64e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 51.13  E-value: 2.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  775 AVALDwdsRDDHVYWTDVSTDTIS--------RAKWDGTGQEvvvDTSLESPAGLAIDwVTNKLYWTDAGTDRIEVANTD 846
Cdd:cd14956    17 GIAVD---ADDNVYVADARNGRIQvfdkdgtfLRRFGTTGDG---PGQFGRPRGLAVD-KDGWLYVADYWGDRIQVFTLT 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  847 GSMRTvlIWEN-------LDRPRDIVVEPmGGYMYWTDWGaSPKIERAGMDAS-----GRQVIISSNLTWPNGLAIDyGS 914
Cdd:cd14956    90 GELQT--IGGSsgsgpgqFNAPRGVAVDA-DGNLYVADFG-NQRIQKFDPDGSflrqwGGTGIEPGSFNYPRGVAVD-PD 164


                  ....*...
gi 157384998  915 QRLYWADA 922
Cdd:cd14956   165 GTLYVADT 172
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 774-969 3.52e-06

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 50.78  E-value: 3.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  774 SAVALDwdsRDDHVYWTDVSTDTISraKWDGTGQEVVV-------DTSLESPAGLAIDwVTNKLYWTDAGTDRIEVANTD 846
Cdd:cd05819    11 QGIAVD---SSGNIYVADTGNNRIQ--VFDPDGNFITSfgsfgsgDGQFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  847 GSMRTVLI-----WENLDRPRDIVVEPMgGYMYWTDWGASpKIERagMDASGR-QVIISSNLTW------PNGLAIDyGS 914
Cdd:cd05819    85 GNFLASFGgsgdgDGEFNGPRGIAVDSS-GNIYVADTGNH-RIQK--FDPDGEfLTTFGSGGSGpgqfngPTGVAVD-SD 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157384998  915 QRLYWADAGMKTI-------EFAGLDGSkrKVLIGSQLPHPFGLTLYGE-RIYWTDWQTKSIQ 969
Cdd:cd05819   160 GNIYVADTGNHRIqvfdpdgNFLTTFGS--TGTGPGQFNYPTGIAVDSDgNIYVADSGNNRVQ 220
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1087-1242 3.69e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 50.75  E-value: 3.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1087 GVDPQEGKVYWSDSTLHRISRANLDGSQ-----HEDIITTGLQTTDGLAVDAiGRKVYWTDTGTNRIEVGNLDGSMRKVL 1161
Cdd:cd14963    14 GVAVSDGRIYVADTNNHRVQVFDYEGKFkksfgGPGTGPGEFKYPYGIAVDS-DGNIYVADLYNGRIQVFDPDGKFLKYF 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1162 VWQ----NLDSPRAIVLYHemGFMYWTDWGENA--------KLERS-GMDGSDRAvlinnNLGWPNGLTVDKAsSQLLWA 1228
Cdd:cd14963    93 PEKkdrvKLISPAGLAIDD--GKLYVSDVKKHKvivfdlegKLLLEfGKPGSEPG-----ELSYPNGIAVDED-GNIYVA 164

                         170
                  ....*....|....
gi 157384998 1229 DAHTERIEAADLNG 1242
Cdd:cd14963   165 DSGNGRIQVFDKNG 178
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 482-616 5.15e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 50.37  E-value: 5.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  482 VFWSDVTLDRILRANLNGSNVEEVVSTG-----LESPGGLAVDwVHDKLYWTDSGTSRIEVANLDGahrKVLLWQNLEK- 555
Cdd:cd14963   114 LYVSDVKKHKVIVFDLEGKLLLEFGKPGsepgeLSYPNGIAVD-EDGNIYVADSGNGRIQVFDKNG---KFIKELNGSPd 189

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157384998  556 -------PRAIALHPmEGTIYWTDwgN-TPRIEASSMDG-----SGRRIIADTHLFWPNGLTIDYAGrRMYWVD 616
Cdd:cd14963   190 gksgfvnPRGIAVDP-DGNLYVVD--NlSHRVYVFDEQGkelftFGGRGKDDGQFNLPNGLFIDDDG-RLYVTD 259
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1390-1583 6.34e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.69  E-value: 6.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1390 LDYDSVDGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTDGlavdwvaRNLYWTDTGRNTIeaSRLDGSCRKVLINNS 1469
Cdd:COG3391    37 LAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADG-------RRLYVANSGSGRV--SVIDLATGKVVATIP 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1470 L-DEPRAIAVFPRKGYLFWTDW--GHIAKIeranlDGSERKVLINTDLG-WPNGLTLDYDTRRIYWVDAHLDRIeSA--- 1542
Cdd:COG3391   108 VgGGPRGLAVDPDGGRLYVADSgnGRVSVI-----DTATGKVVATIPVGaGPHGIAVDPDGKRLYVANSGSNTV-SVivs 181

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 157384998 1543 --DL-NGK-LRQVLVSHVSHPFALTQQDRWIY-------WTDWQTKSIQRVD 1583
Cdd:COG3391   182 viDTaTGKvVATIPVGGGPVGVAVSPDGRRLYvanrgsnTSNGGSNTVSVID 233
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 377-398 1.05e-05

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 43.55  E-value: 1.05e-05
                           10        20
                   ....*....|....*....|..
gi 157384998   377 QCTCHTGYRLTEDGHTCQDVNE 398
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 766-806 1.59e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.74  E-value: 1.59e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 157384998    766 VIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDGTG 806
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 785-825 2.79e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.92  E-value: 2.79e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998   785 DHVYWTDVSTD-TISRAKWDGTGQEVVVDTSLESPAGLAIDW 825
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
395-434 2.87e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 2.87e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 157384998    395 DVNECAEEGYCSQG--CTNSEGAFQCWCETGYElrpDRRSCK 434
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYT---DGRNCE 39
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1093-1132 3.24e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.53  E-value: 3.24e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998  1093 GKVYWSDSTLH-RISRANLDGSqHEDIITTG-LQTTDGLAVD 1132
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGS-DRKTLFTDdLQHPNAIAVD 41
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1031-1275 5.65e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 46.90  E-value: 5.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1031 PTGINLLSDGKtcspgmnsflIFA-----RRIDIrmVSLD---IPYFADVVVPINITMKNTIAIgvdpQEGKVYWSDSTL 1102
Cdd:cd14963    58 PYGIAVDSDGN----------IYVadlynGRIQV--FDPDgkfLKYFPEKKDRVKLISPAGLAI----DDGKLYVSDVKK 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1103 HRISRANLDGSQHEDIITTG-----LQTTDGLAVDAIGRkVYWTDTGTNRIEVGNLDGSmrkvlvwqnldspraivlyhe 1177
Cdd:cd14963   122 HKVIVFDLEGKLLLEFGKPGsepgeLSYPNGIAVDEDGN-IYVADSGNGRIQVFDKNGK--------------------- 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1178 mgFMYWtdwgenaklersgMDGSDRAvliNNNLGWPNGLTVDKaSSQLLWADAHTERIEAADLNGANRHTLVSPVQ---- 1253
Cdd:cd14963   180 --FIKE-------------LNGSPDG---KSGFVNPRGIAVDP-DGNLYVVDNLSHRVYVFDEQGKELFTFGGRGKddgq 240

                         250       260
                  ....*....|....*....|....*
gi 157384998 1254 --HPYGLTLLDS-YIYWTDWQTRSI 1275
Cdd:cd14963   241 fnLPNGLFIDDDgRLYVTDRENNRV 265
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1379-1418 6.21e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.82  E-value: 6.21e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 157384998   1379 VPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSN 1418
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 938-979 6.66e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.82  E-value: 6.66e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 157384998    938 KVLIGSQLPHPFGLTL--YGERIYWTDWQTKSIQSADrLTGLDR 979
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVAN-LDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 915-954 7.03e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 41.76  E-value: 7.03e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 157384998   915 QRLYWADAGMK-TIEFAGLDGSKRKVLIGSQLPHPFGLTLY 954
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVD 41
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1086-1283 7.57e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 46.54  E-value: 7.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1086 IGVDPQeGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTD-----GLAVDAIGRkVYWTDTGTNRIEVGNLDGsmRKV 1160
Cdd:cd05819    13 IAVDSS-GNIYVADTGNNRIQVFDPDGNFITSFGSFGSGDGQfnepaGVAVDSDGN-LYVADTGNHRIQKFDPDG--NFL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1161 LVW-------QNLDSPRAIVLyHEMGFMYWTDWGENA---------KLERSGMDGSDRAVLINnnlgwPNGLTVDkaSSQ 1224
Cdd:cd05819    89 ASFggsgdgdGEFNGPRGIAV-DSSGNIYVADTGNHRiqkfdpdgeFLTTFGSGGSGPGQFNG-----PTGVAVD--SDG 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157384998 1225 LLW-ADAHTERIEAADLNGA------NRHTLVSPVQHPYGLTlLDS--YIYWTDWQTRSIHRADKGTG 1283
Cdd:cd05819   161 NIYvADTGNHRIQVFDPDGNflttfgSTGTGPGQFNYPTGIA-VDSdgNIYVADSGNNRVQVFDPDGA 227
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1159-1202 8.85e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.43  E-value: 8.85e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 157384998   1159 KVLVWQNLDSPRAIVLYHEMGFMYWTDWGeNAKLERSGMDGSDR 1202
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1617-1648 9.13e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.07  E-value: 9.13e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 157384998  1617 CGVNNGGCTHLCFARASDFVCACPD----EPDSRPC 1648
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEgyelQDDGRTC 36
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 780-921 9.28e-05

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 46.10  E-value: 9.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998   780 WDSRDDHVYWTDVSTDTISRAkWDGTGQEVVVDTSleSPAGLAIDWVTNKLYWTDAgtDRIEVANTDGSMRTVLIWENLD 859
Cdd:pfam08450    7 WDEEEGALYWVDILGGRIHRL-DPATGKETVWDTP--GPVGAIAPRDDGGLIVALK--DGVALLDLATGELTPLADPEDD 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157384998   860 -----RPRDIVVEPMGGYmywtdWGASPKIERAGM---------DASGRQVIISSNLTWPNGLAIDYGSQRLYWAD 921
Cdd:pfam08450   82 dwplnRFNDGKVDPDGRF-----WFGTMGDDEAPGgdpgalyrlDPDGKLTRVLDGLTISNGLAWSPDGRTLYFAD 152
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 766-923 9.72e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 46.05  E-value: 9.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  766 VIPLADVRSA--VALDwdsRDDHVYWTDVSTDTISRAKWDGTGQEVVVDTSLESPAGLAIDWVTNkLYWTDAGTDRIEVA 843
Cdd:cd14952     3 VLPFTGLDGPggVAVD---AAGNVYVADSGNNRVLKLAAGSTTQTVLPFTGLYQPQGVAVDAAGT-VYVTDFGNNRVLKL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  844 NTDGSMRTVLIWENLDRPRDIVVEPmGGYMYWTDWGASPKIERAGmdASGRQVIIS-SNLTWPNGLAIDyGSQRLYWADA 922
Cdd:cd14952    79 AAGSTTQTVLPFTGLNDPTGVAVDA-AGNVYVADTGNNRVLKLAA--GSNTQTVLPfTGLSNPDGVAVD-GAGNVYVTDT 154


                  .
gi 157384998  923 G 923
Cdd:cd14952   155 G 155
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 633-673 1.12e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.05  E-value: 1.12e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157384998    633 KAVISQGLPHP--FAITVFEDSLYWTDWHTKSINSANkFTGKN 673
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN-LDGTN 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 399-433 1.78e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.30  E-value: 1.78e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 157384998   399 CAEE-GYCSQGCTNSEGAFQCWCETGYELRPDRRSC 433
Cdd:pfam14670    1 CSVNnGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 395-427 1.81e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 1.81e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 157384998  395 DVNECAEEGYCSQG--CTNSEGAFQCWCETGYELR 427
Cdd:cd00054     1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGYTGR 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 956-996 2.03e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 40.61  E-value: 2.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998   956 ERIYWTDWQTKSIQSADRLTGLDRETL-QENLENLMDIHVFH 996
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLfTDDLQHPNAIAVDP 42
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 1069-1148 5.50e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 43.74  E-value: 5.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1069 FADVVVPInitmkntiAIGVDPQeGKVYWSDSTLHRISRanLDGSQHEDIIT--TGLQTTDGLAVDAIGrKVYWTDTGTN 1146
Cdd:cd14952   174 FTGLNSPS--------GVAVDTA-GNVYVTDHGNNRVLK--LAAGSTTPTVLpfTGLNGPLGVAVDAAG-NVYVADRGND 241


                  ..
gi 157384998 1147 RI 1148
Cdd:cd14952   242 RV 243
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 480-520 7.02e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.07  E-value: 7.02e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998   480 ELVFWSDVTLD-RILRANLNGSNVEEVVSTGLESPGGLAVDW 520
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 1093-1221 7.54e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 43.35  E-value: 7.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1093 GKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAiGRKVYWTDTGTNRieVGNLDG--SMRKVLVWQNLDSPR 1170
Cdd:cd14952    63 GTVYVTDFGNNRVLKLAAGSTTQTVLPFTGLNDPTGVAVDA-AGNVYVADTGNNR--VLKLAAgsNTQTVLPFTGLSNPD 139

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 157384998 1171 AIVLyHEMGFMYWTDWGEN--AKLErSGmdGSDRAVLINNNLGWPNGLTVDKA 1221
Cdd:cd14952   140 GVAV-DGAGNVYVTDTGNNrvLKLA-AG--STTQTVLPFTGLNSPSGVAVDTA 188
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1396-1583 7.62e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 43.34  E-value: 7.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1396 DGKVYYTDVFLDVIRRADLNGSNMETVIGRGLKTTdGLAVDWvARNLYWTDTGRNTIEASRLDGSCRKVLinNSLDEPRA 1475
Cdd:COG3386    18 DGRLYWVDIPGGRIHRYDPDGGAVEVFAEPSGRPN-GLAFDP-DGRLLVADHGRGLVRFDPADGEVTVLA--DEYGKPLN 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1476 I---AVFPRKGYLFWTD---WGHIAKIERANLDGSERKVLinTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADL--NGK 1547
Cdd:COG3386    94 RpndGVVDPDGRLYFTDmgeYLPTGALYRVDPDGSLRVLA--DGLTFPNGIAFSPDGRTLYVADTGAGRIYRFDLdaDGT 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 157384998 1548 L--RQVLVSHVSHP-----FALTQQDRwIYWTDWQTKSIQRVD 1583
Cdd:COG3386   172 LgnRRVFADLPDGPggpdgLAVDADGN-LWVALWGGGGVVRFD 213
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1432-1548 8.63e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 43.34  E-value: 8.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1432 GLAVDWVARnLYWTDTGRNTIeaSRLDGSCRKV-LINNSLDE----PRAIAVFPrKGYLFWTDWGHiAKIERANLDGSER 1506
Cdd:cd14962    16 GVAADGRGR-IYVADTGRGAV--FVFDLPNGKVfVIGNAGPNrfvsPIGVAIDA-NGNLYVSDAEL-GKVFVFDRDGKFL 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 157384998 1507 KVlINTDLGW--PNGLTLDYDTRRIYWVDAHLDRIESADLNGKL 1548
Cdd:cd14962    91 RA-IGAGALFkrPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRL 133
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1245-1286 9.95e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 9.95e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 157384998   1245 RHTLVSPVQHPYGLTL--LDSYIYWTDWQTRSIHRADKgTGSNV 1286
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVANL-DGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1549-1589 1.11e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 38.35  E-value: 1.11e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157384998   1549 RQVLVSHVSHP--FALTQQDRWIYWTDWQTKSIQRVDkYSGRN 1589
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN-LDGTN 42
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 509-651 1.84e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 42.28  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  509 GLESPGGLAVDWvhDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEK-----PRAIALHPmEGTIYWTDWGNTpRIEASS 583
Cdd:cd14963     8 PLNKPMGVAVSD--GRIYVADTNNHRVQVFDYEGKFKKSFGGPGTGPgefkyPYGIAVDS-DGNIYVADLYNG-RIQVFD 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157384998  584 MDGSGRRIIADT----HLFWPNGLTIDyaGRRMYWVDAKHHVIERANLDGSHRKAVISQG-----LPHPFAITVFED 651
Cdd:cd14963    84 PDGKFLKYFPEKkdrvKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLEFGKPGsepgeLSYPNGIAVDED 158
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1396-1547 1.89e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 42.28  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1396 DGKVYYTD-------VFldvirraDLNGSNMETVIGRG-----LKTTDGLAVDwVARNLYWTDTGRNTIEASRLDGSCRK 1463
Cdd:cd14963    19 DGRIYVADtnnhrvqVF-------DYEGKFKKSFGGPGtgpgeFKYPYGIAVD-SDGNIYVADLYNGRIQVFDPDGKFLK 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1464 VL----INNSLDEPRAIAVFprKGYLFWTDWGHiAKIERANLDGseRKVLI-------NTDLGWPNGLTLDyDTRRIYWV 1532
Cdd:cd14963    91 YFpekkDRVKLISPAGLAID--DGKLYVSDVKK-HKVIVFDLEG--KLLLEfgkpgsePGELSYPNGIAVD-EDGNIYVA 164

                         170
                  ....*....|....*
gi 157384998 1533 DAHLDRIESADLNGK 1547
Cdd:cd14963   165 DSGNGRIQVFDKNGK 179
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1388-1559 2.06e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 42.19  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1388 ISLDYDSvDGKVYYTDVFLDVIRRADLNGsNMETVIGRGLKTTD--GLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVL 1465
Cdd:cd14962    60 IGVAIDA-NGNLYVSDAELGKVFVFDRDG-KFLRAIGAGALFKRptGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDI 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1466 -----INNSLDEPRAIAVfPRKGYLFWTDWGHiAKIERANLDGSERKVL--INTDLGW---PNGLTLDYDTRrIYWVDAH 1535
Cdd:cd14962   138 gkrgsGPGEFNLPTDLAV-DRDGNLYVTDTMN-FRVQIFDADGKFLRSFgeRGDGPGSfarPKGIAVDSEGN-IYVVDAA 214

                         170       180
                  ....*....|....*....|....
gi 157384998 1536 LDRIESADLNGKLRQVLVSHVSHP 1559
Cdd:cd14962   215 FDNVQIFNPEGELLLTVGGPGSGP 238
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 1088-1221 2.45e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 41.81  E-value: 2.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1088 VDPQeGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGrKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLD 1167
Cdd:cd14952   101 VDAA-GNVYVADTGNNRVLKLAAGSNTQTVLPFTGLSNPDGVAVDGAG-NVYVTDTGNNRVLKLAAGSTTQTVLPFTGLN 178

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 157384998 1168 SPRAIVLYHEmGFMYWTDWGENAKLE-RSGMDGSdrAVLINNNLGWPNGLTVDKA 1221
Cdd:cd14952   179 SPSGVAVDTA-GNVYVTDHGNNRVLKlAAGSTTP--TVLPFTGLNGPLGVAVDAA 230
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1088-1148 3.50e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 41.42  E-value: 3.50e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 157384998 1088 VDPQeGKVYWSDSTLH----RISRANLDGSQHedIITTGLQTTDGLAVDAIGRKVYWTDTGTNRI 1148
Cdd:COG3386   100 VDPD-GRLYFTDMGEYlptgALYRVDPDGSLR--VLADGLTFPNGIAFSPDGRTLYVADTGAGRI 161
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 482-575 4.47e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 41.04  E-value: 4.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998  482 VFWSDVTLDRILRANLnGSNVEEVVS-TGLESPGGLAVDWVHDkLYWTDSGTSRieVANLD-GAH-RKVLLWQNLEKPRA 558
Cdd:cd14952   149 VYVTDTGNNRVLKLAA-GSTTQTVLPfTGLNSPSGVAVDTAGN-VYVTDHGNNR--VLKLAaGSTtPTVLPFTGLNGPLG 224

                          90
                  ....*....|....*..
gi 157384998  559 IALHPMeGTIYWTDWGN 575
Cdd:cd14952   225 VAVDAA-GNVYVADRGN 240
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1527-1563 5.61e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 36.37  E-value: 5.61e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 157384998  1527 RRIYWVDAHLD-RIESADLNGKLRQVLVSH-VSHPFALT 1563
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDdLQHPNAIA 39
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1397-1437 5.61e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 36.37  E-value: 5.61e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157384998  1397 GKVYYTDVFLD-VIRRADLNGSNMETVIGRGLKTTDGLAVDW 1437
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1080-1150 6.79e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 40.73  E-value: 6.79e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157384998 1080 MKNTIAIGVDPQeGKVYWSDSTLHRISRANLDGSQHEDIITTG-----LQTTDGLAVDAIGRkVYWTDTGTNRIEV 1150
Cdd:cd14956   200 FNYPYGIAIDPD-GNVFVADFGNNRIQKFTADGTFLTSWGSPGtgpgqFKNPWGVVVDADGT-VYVADSNNNRVQR 273
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 1086-1156 6.93e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 40.71  E-value: 6.93e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 157384998 1086 IGVDpQEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTD-----GLAVDAIGrKVYWTDTGTNRIEVGNLDGS 1156
Cdd:cd14957    70 IAVD-SNGNIYVADTDNNRIQVFNSSGVYQYSIGTGGSGDGQfngpyGIAVDSNG-NIYVADTGNHRIQVFTSSGT 143
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1123-1243 9.08e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 40.26  E-value: 9.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1123 LQTTDGLAVDAIGRkVYWTDTGTNRIEVGNLDGsmRKVLVW-----QNLDSPRAIVLyHEMGFMYWTDwGENAKLERSGM 1197
Cdd:cd14962    11 LTRPYGVAADGRGR-IYVADTGRGAVFVFDLPN--GKVFVIgnagpNRFVSPIGVAI-DANGNLYVSD-AELGKVFVFDR 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 157384998 1198 DGSDRAVlINNNLGW--PNGLTVDKASSQLLWADAHTERIEAADLNGA 1243
Cdd:cd14962    86 DGKFLRA-IGAGALFkrPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGR 132
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1085-1283 9.30e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 40.00  E-value: 9.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1085 AIGVDPqEGKVYWSDSTLHRISRANLDGSQHEDIITTGLQTTDGLAVDAIGRkVYWTDTGTNRIevGNLDGsmrkvlvwq 1164
Cdd:COG4257    21 DVAVDP-DGAVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDPDGN-LWFTDNGNNRI--GRIDP--------- 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157384998 1165 nldspraivlyhemgfmywtdwgENAKLERSGMDGSDRAvlinnnlgwPNGLTVDkaSSQLLW-ADAHTERIeaADLNGA 1243
Cdd:COG4257    88 -----------------------KTGEITTFALPGGGSN---------PHGIAFD--PDGNLWfTDQGGNRI--GRLDPA 131

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 157384998 1244 NRHTLV--SPVQH--PYGLTL-LDSYIYWTDWQTRSIHRADKGTG 1283
Cdd:COG4257   132 TGEVTEfpLPTGGagPYGIAVdPDGNLWVTDFGANAIGRIDPDTG 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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