platelet basic protein preproprotein [Homo sapiens]
Protein Classification
CXC family chemokine( domain architecture ID 10084510)
CXC family chemokine such as interleukin-8, also called C-X-C motif chemokine 8, that is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes, and is involved in neutrophil activation
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Chemokine_CXC | cd00273 | Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ... |
60-122 | 1.93e-26 | ||
Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups. : Pssm-ID: 238171 Cd Length: 64 Bit Score: 93.48 E-value: 1.93e-26
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| Name | Accession | Description | Interval | E-value | ||
| Chemokine_CXC | cd00273 | Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ... |
60-122 | 1.93e-26 | ||
Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups. Pssm-ID: 238171 Cd Length: 64 Bit Score: 93.48 E-value: 1.93e-26
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| SCY | smart00199 | Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ... |
60-119 | 6.43e-16 | ||
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response. Pssm-ID: 197570 Cd Length: 59 Bit Score: 66.50 E-value: 6.43e-16
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| IL8 | pfam00048 | Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ... |
61-119 | 4.97e-14 | ||
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds. Pssm-ID: 459650 Cd Length: 60 Bit Score: 61.90 E-value: 4.97e-14
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| Name | Accession | Description | Interval | E-value | ||
| Chemokine_CXC | cd00273 | Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ... |
60-122 | 1.93e-26 | ||
Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif which may be a general requirement for binding to CXC chemokine receptors; those with the ELR motif are chemotatic for neutrophils and have been shown to be angiogenic, while those without the motif act on T and B cells, and are typically angiostatic; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups. Pssm-ID: 238171 Cd Length: 64 Bit Score: 93.48 E-value: 1.93e-26
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| Chemokine | cd00169 | Chemokine: small cytokines, including a number of secreted growth factors and interferons ... |
65-121 | 1.51e-18 | ||
Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups. Pssm-ID: 238098 Cd Length: 59 Bit Score: 73.53 E-value: 1.51e-18
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| SCY | smart00199 | Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved ... |
60-119 | 6.43e-16 | ||
Intercrine alpha family (small cytokine C-X-C) (chemokine CXC); Family of cytokines involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response. Pssm-ID: 197570 Cd Length: 59 Bit Score: 66.50 E-value: 6.43e-16
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| IL8 | pfam00048 | Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted ... |
61-119 | 4.97e-14 | ||
Small cytokines (intecrine/chemokine), interleukin-8 like; Includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity. Structure contains two highly conserved disulfide bonds. Pssm-ID: 459650 Cd Length: 60 Bit Score: 61.90 E-value: 4.97e-14
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| Chemokine_CC | cd00272 | Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ... |
72-119 | 9.50e-03 | ||
Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. 2HCC) contain an additional disulfide bond which is thought to compensate for the highly conserved Trp missing in these; chemotatic for monocytes, macrophages, eosinophils, basophils, and T cells, but not neutrophils; exist as monomers and dimers, but are believed to be functional as monomers; found only in vertebrates and a few viruses; a subgroup of CC, identified by an N-terminal DCCL motif (Exodus-1, Exodus-2, and Exodus-3), has been shown to inhibit specific types of human cancer cell growth in a mouse model. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for the additional chemokine subgroups, and Chemokine_CC_DCCL for the DCCL subgroup of this CD. Pssm-ID: 238170 Cd Length: 57 Bit Score: 32.60 E-value: 9.50e-03
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