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Conserved domains on  [gi|4506969|ref|NP_003028|]
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signaling lymphocytic activation molecule isoform b precursor [Homo sapiens]

Protein Classification

SLAM domain-containing protein( domain architecture ID 10533246)

SLAM domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SLAM pfam06214
Signaling lymphocytic activation molecule (SLAM) protein; This family consists of several ...
 1-125 1.55e-77

Signaling lymphocytic activation molecule (SLAM) protein; This family consists of several mammalian signaling lymphocytic activation molecule (SLAM) proteins. Optimal T cell activation and expansion require engagement of the TCR plus co-stimulatory signals delivered through accessory molecules. SLAM, a 70-kDa co-stimulatory molecule belonging to the Ig superfamily, is defined as a human cell surface molecule that mediates CD28-independent proliferation of human T cells and IFN-gamma production by human Th1 and Th2 clones. SLAM has also been recognized as a receptor for measles virus.


:

Pssm-ID: 461853  Cd Length: 125  Bit Score: 233.12  E-value: 1.55e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506969      1 MDPKGLLSLTFVLFLSLAFGASYGTGGRMMNCPKILRQLGSKVLLPLTYERINKSMNKSIHIVVTMAKSLENSVENKIVS 80
Cdd:pfam06214   1 MDPKGLLSLNLLLFLSLAFELSCGTGEGLMNCPKILGQLGSSVLLPLTSEGISKSMNKSIHILVTMAESPGSSVKKKIVS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 4506969     81 LDPSEAGPPRYLGDRYKFYLENLTLGIRESRKEDEGWYLMTLEKN 125
Cdd:pfam06214  81 LDLSEGGSPRYLEDGYKFHLENLSLEILESRKEDEGWYFMTLEEN 125
 
Name Accession Description Interval E-value
SLAM pfam06214
Signaling lymphocytic activation molecule (SLAM) protein; This family consists of several ...
 1-125 1.55e-77

Signaling lymphocytic activation molecule (SLAM) protein; This family consists of several mammalian signaling lymphocytic activation molecule (SLAM) proteins. Optimal T cell activation and expansion require engagement of the TCR plus co-stimulatory signals delivered through accessory molecules. SLAM, a 70-kDa co-stimulatory molecule belonging to the Ig superfamily, is defined as a human cell surface molecule that mediates CD28-independent proliferation of human T cells and IFN-gamma production by human Th1 and Th2 clones. SLAM has also been recognized as a receptor for measles virus.


Pssm-ID: 461853  Cd Length: 125  Bit Score: 233.12  E-value: 1.55e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506969      1 MDPKGLLSLTFVLFLSLAFGASYGTGGRMMNCPKILRQLGSKVLLPLTYERINKSMNKSIHIVVTMAKSLENSVENKIVS 80
Cdd:pfam06214   1 MDPKGLLSLNLLLFLSLAFELSCGTGEGLMNCPKILGQLGSSVLLPLTSEGISKSMNKSIHILVTMAESPGSSVKKKIVS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 4506969     81 LDPSEAGPPRYLGDRYKFYLENLTLGIRESRKEDEGWYLMTLEKN 125
Cdd:pfam06214  81 LDLSEGGSPRYLEDGYKFHLENLSLEILESRKEDEGWYFMTLEEN 125
 
Name Accession Description Interval E-value
SLAM pfam06214
Signaling lymphocytic activation molecule (SLAM) protein; This family consists of several ...
 1-125 1.55e-77

Signaling lymphocytic activation molecule (SLAM) protein; This family consists of several mammalian signaling lymphocytic activation molecule (SLAM) proteins. Optimal T cell activation and expansion require engagement of the TCR plus co-stimulatory signals delivered through accessory molecules. SLAM, a 70-kDa co-stimulatory molecule belonging to the Ig superfamily, is defined as a human cell surface molecule that mediates CD28-independent proliferation of human T cells and IFN-gamma production by human Th1 and Th2 clones. SLAM has also been recognized as a receptor for measles virus.


Pssm-ID: 461853  Cd Length: 125  Bit Score: 233.12  E-value: 1.55e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506969      1 MDPKGLLSLTFVLFLSLAFGASYGTGGRMMNCPKILRQLGSKVLLPLTYERINKSMNKSIHIVVTMAKSLENSVENKIVS 80
Cdd:pfam06214   1 MDPKGLLSLNLLLFLSLAFELSCGTGEGLMNCPKILGQLGSSVLLPLTSEGISKSMNKSIHILVTMAESPGSSVKKKIVS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 4506969     81 LDPSEAGPPRYLGDRYKFYLENLTLGIRESRKEDEGWYLMTLEKN 125
Cdd:pfam06214  81 LDLSEGGSPRYLEDGYKFHLENLSLEILESRKEDEGWYFMTLEEN 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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