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Conserved domains on  [gi|68303809|ref|NP_003414|]
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zinc finger protein 43 isoform 2 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-63 2.64e-32

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 119.23  E-value: 2.64e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809      4 LTFMDVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFLGIAVSKPDLITCLEQEKEPW 63
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
286-754 2.66e-16

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.44  E-value: 2.66e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 286 YKCKECAKAFNQSSNLTEHKKIHPGEKPYKC--EECGKAFNWPSTLTKHKRIHTGEKPYTCEECGKAFNQFSNLTTHKRI 363
Cdd:COG5048  34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSS 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 364 HTAE-KFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTHTGEkpykcEECGKAFNWPSTLT 442
Cdd:COG5048 114 SSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNLSLLI 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 443 KHNRIHTGEKPYKCEvCGKAFNQFSNLTTHKRIHTAEKPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEECGKAFKWS 522
Cdd:COG5048 189 SSNVSTSIPSSSENS-PLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 523 SKLTEHKITHTGEkpykceecgkafnhfsilTKHKRIHTgekPYKCEECGKAFTQSSNLTTHK--KIHTGEKFYKCEE-- 598
Cdd:COG5048 268 ASSQSSSPNESDS------------------SSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFSCpy 326

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 599 --CGKAFTQSSNLTTHKKIHTGGKPYKCEECgkafnqfSTLTKHKIIHTEEKPykceecgkafkwsSTLTKHKIIHTGEK 676
Cdd:COG5048 327 slCGKLFSRNDALKRHILLHTSISPAKEKLL-------NSSSKFSPLLNNEPP-------------QSLQQYKDLKNDKK 386

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 677 PYKCE-ECGKAFKLSSTLSTHKIIHTGEKP--YKCEKCGKAFNRSSNLIEHKKIHTGEQPYKCEECGKaFNYSSHLNTHK 753
Cdd:COG5048 387 SETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHG 465


                .
gi 68303809 754 R 754
Cdd:COG5048 466 K 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
733-794 8.08e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 8.08e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68303809 733 PYKCEECGKAFNYSSHLNTHKRIHTKEQPYKC--KECGKAFNQYSNLTTHNKIHTGEKLYKPED 794
Cdd:COG5048  33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSK 96
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-63 2.64e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 119.23  E-value: 2.64e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809      4 LTFMDVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFLGIAVSKPDLITCLEQEKEPW 63
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 8.09e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.90  E-value: 8.09e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 68303809     3 PLTFMDVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 8.20e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.20  E-value: 8.20e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 68303809   4 LTFMDVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFL 43
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
286-754 2.66e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.44  E-value: 2.66e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 286 YKCKECAKAFNQSSNLTEHKKIHPGEKPYKC--EECGKAFNWPSTLTKHKRIHTGEKPYTCEECGKAFNQFSNLTTHKRI 363
Cdd:COG5048  34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSS 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 364 HTAE-KFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTHTGEkpykcEECGKAFNWPSTLT 442
Cdd:COG5048 114 SSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNLSLLI 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 443 KHNRIHTGEKPYKCEvCGKAFNQFSNLTTHKRIHTAEKPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEECGKAFKWS 522
Cdd:COG5048 189 SSNVSTSIPSSSENS-PLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 523 SKLTEHKITHTGEkpykceecgkafnhfsilTKHKRIHTgekPYKCEECGKAFTQSSNLTTHK--KIHTGEKFYKCEE-- 598
Cdd:COG5048 268 ASSQSSSPNESDS------------------SSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFSCpy 326

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 599 --CGKAFTQSSNLTTHKKIHTGGKPYKCEECgkafnqfSTLTKHKIIHTEEKPykceecgkafkwsSTLTKHKIIHTGEK 676
Cdd:COG5048 327 slCGKLFSRNDALKRHILLHTSISPAKEKLL-------NSSSKFSPLLNNEPP-------------QSLQQYKDLKNDKK 386

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 677 PYKCE-ECGKAFKLSSTLSTHKIIHTGEKP--YKCEKCGKAFNRSSNLIEHKKIHTGEQPYKCEECGKaFNYSSHLNTHK 753
Cdd:COG5048 387 SETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHG 465


                .
gi 68303809 754 R 754
Cdd:COG5048 466 K 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
553-577 5.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 5.02e-04
                          10        20
                  ....*....|....*....|....*
gi 68303809   553 LTKHKRIHTGEKPYKCEECGKAFTQ 577
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
733-794 8.08e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 8.08e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68303809 733 PYKCEECGKAFNYSSHLNTHKRIHTKEQPYKC--KECGKAFNQYSNLTTHNKIHTGEKLYKPED 794
Cdd:COG5048  33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSK 96
zf-H2C2_2 pfam13465
Zinc-finger double domain;
748-773 1.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.73e-03
                          10        20
                  ....*....|....*....|....*.
gi 68303809   748 HLNTHKRIHTKEQPYKCKECGKAFNQ 773
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-63 2.64e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 119.23  E-value: 2.64e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809      4 LTFMDVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFLGIAVSKPDLITCLEQEKEPW 63
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 8.09e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.90  E-value: 8.09e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 68303809     3 PLTFMDVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 8.20e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.20  E-value: 8.20e-18
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 68303809   4 LTFMDVAIEFCLEEWQCLDIAQQNLYRNVMLENYRNLVFL 43
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
286-754 2.66e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 82.44  E-value: 2.66e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 286 YKCKECAKAFNQSSNLTEHKKIHPGEKPYKC--EECGKAFNWPSTLTKHKRIHTGEKPYTCEECGKAFNQFSNLTTHKRI 363
Cdd:COG5048  34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSS 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 364 HTAE-KFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTHTGEkpykcEECGKAFNWPSTLT 442
Cdd:COG5048 114 SSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNLSLLI 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 443 KHNRIHTGEKPYKCEvCGKAFNQFSNLTTHKRIHTAEKPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEECGKAFKWS 522
Cdd:COG5048 189 SSNVSTSIPSSSENS-PLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 523 SKLTEHKITHTGEkpykceecgkafnhfsilTKHKRIHTgekPYKCEECGKAFTQSSNLTTHK--KIHTGEKFYKCEE-- 598
Cdd:COG5048 268 ASSQSSSPNESDS------------------SSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFSCpy 326

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 599 --CGKAFTQSSNLTTHKKIHTGGKPYKCEECgkafnqfSTLTKHKIIHTEEKPykceecgkafkwsSTLTKHKIIHTGEK 676
Cdd:COG5048 327 slCGKLFSRNDALKRHILLHTSISPAKEKLL-------NSSSKFSPLLNNEPP-------------QSLQQYKDLKNDKK 386

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 677 PYKCE-ECGKAFKLSSTLSTHKIIHTGEKP--YKCEKCGKAFNRSSNLIEHKKIHTGEQPYKCEECGKaFNYSSHLNTHK 753
Cdd:COG5048 387 SETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHG 465


                .
gi 68303809 754 R 754
Cdd:COG5048 466 K 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
380-782 3.71e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 3.71e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 380 SRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLTHTGEKPYKC--EECGKAFNWPSTLTKHNRIHTGEKPYKCE 457
Cdd:COG5048  16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 458 VCGKAFNQFSNLTTHKRIHTAE-KPYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCEEC--------------------- 515
Cdd:COG5048  96 KSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpans 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 516 --GKAFKWSSKLTEHKITHTGEKPYKCEECGKaFNHFSILTKHKRIHTGEKPYKCEECGKAFTQSSNLTTHKKIHTGEKF 593
Cdd:COG5048 176 lsKDPSSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 594 YKCEECGKAFTQSSNLTTHKKIHTG-------GKPYKCEECGKAFNQFSTLTKHK--IIHTEE--KPYKCEE--CGKAFK 660
Cdd:COG5048 255 SSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFS 334

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 661 WSSTLTKHKIIHTGEKPYKC--EECGKAF------KLSSTLSTHKIIHTGEKPYKCE-KCGKAFNRSSNLIEHKKIHTGE 731
Cdd:COG5048 335 RNDALKRHILLHTSISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSF 414

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 68303809 732 QP--YKCEECGKAFNYSSHLNTHKRIHTKEQPYKCkECGKAFNQYSNLTTHNK 782
Cdd:COG5048 415 RPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
203-573 3.06e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.64  E-value: 3.06e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 203 KCEKCGKAFNCPSIITKHKRINTGEKPYTCEECGKVFNWS----------------SRLTTHKKNYTRYKLYKCE----- 261
Cdd:COG5048  35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplelsrhlrthhnnpSDLNSKSLPLSNSKASSSSlssss 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 262 --------ECGKAFNKSSILTTHKIIRTGEKFYKCKECAKAFNQSSNLTEHKKIHPGEKPYKCEECGKAFNWPStltkHK 333
Cdd:COG5048 115 snsndnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI----SS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 334 RIHTGEKPYTCEECGKAFNQFSNLTTHKRIHTAEKFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKL 413
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 414 TEHKLTHTGE-------KPYKCEECGKAFNWPSTLTKHNR--IHTGE--KPYKC--EVCGKAFNQFSNLTTHKRIHTAEK 480
Cdd:COG5048 271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSIS 350

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 481 PYKCEECGKAFSRSSNLTKHKKIHIEKKPYKCE---------ECGKAFKWSSKLTEHKITHTGEKP--YKCEECGKAFNH 549
Cdd:COG5048 351 PAKEKLLNSSSKFSPLLNNEPPQSLQQYKDLKNdkksetlsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                       410       420
                ....*....|....*....|....
gi 68303809 550 FSILTKHKRIHTGEKPYKCEECGK 573
Cdd:COG5048 431 HYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
452-784 3.02e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 3.02e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 452 KPYKCEVCGKAFNQFSNLTTHKRIHTAEKPYKC--EECGKAFSRSSNLTKHKKIHIEKKPYKCE-ECGKAFKWSSKLTEH 528
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 529 KITHTGEKPYKCEECGKAFNHFSILTKHKRIHTGEKPYKCEECGKAFTQSSNLTTHKKIHTGEKFykceeCGKAFTQSSN 608
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSL-----SKDPSSNLSL 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 609 LTTHKKIHTGGKPYKCEECGKA------------FNQFSTLTKHKIIHTEEKPYKCE---------------ECGKAFKW 661
Cdd:COG5048 187 LISSNVSTSIPSSSENSPLSSSysipssssdqnlENSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLP 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 662 SSTLTKHKIIHTGE-------KPYKCEECGKAFKLSSTLSTHK--IIHTGE--KPYKC--EKCGKAFNRSSNLIEHKKIH 728
Cdd:COG5048 267 TASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLH 346

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 68303809 729 TGEQPYKCEEC------GKAFNYSSHLNTHKRIHTKEQPYKC---KECGKAFNQYSNLTTHNKIH 784
Cdd:COG5048 347 TSISPAKEKLLnssskfSPLLNNEPPQSLQQYKDLKNDKKSEtlsNSCIRNFKRDSNLSLHIITH 411
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
536-791 1.13e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 1.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 536 KPYKCEECGKAFNHFSILTKHKRIHTGEKPYKC--EECGKAFTQSSNLTTHKKIHTGEK-FYKCEECGKAFTQSSNLTTH 612
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPsDLNSKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 613 KKIHTGGKPYKCEECGKAFNQFSTLTKHKIIHTEEKPYKCEEC-----------------------GKAFKWSSTLTKHK 669
Cdd:COG5048 112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslsKDPSSNLSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 670 IIHTGEKPYKCEECGKA------------FKLSSTLSTHKIIHTGEKPYKCEK-----------CGKAFNRSSNLIEHKK 726
Cdd:COG5048 192 VSTSIPSSSENSPLSSSysipssssdqnlENSSSSLPLTTNSQLSPKSLLSQSpsslsssdsssSASESPRSSLPTASSQ 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 727 IHTGEQ-----------PYKCEECGKAFNYSSHLNTHKR--IHTKE--QPYKCKE--CGKAFNQYSNLTTHNKIHTGEKL 789
Cdd:COG5048 272 SSSPNEsdsssekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351


                ..
gi 68303809 790 YK 791
Cdd:COG5048 352 AK 353
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 396-473 6.33e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 6.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 396 KPYKCE--ECGKAFKWSSKLTEHKLtHTGEKPYKCEEcgkafnwPSTLtKHNRIHTGEKPYKCEVCGKAFNQFSNLTTHK 473
Cdd:COG5189 348 KPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHEN-------PSPE-KMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 576-669 1.18e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 1.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 576 TQSSNLTThkkihTGEKFYKCE--ECGKAFTQSSNLTTHKKiHTggkpykceECGKAFNQFSTLTKHKIIHTEEKPYKCE 653
Cdd:COG5189 337 TPSRMLKV-----KDGKPYKCPveGCNKKYKNQNGLKYHML-HG--------HQNQKLHENPSPEKMNIFSAKDKPYRCE 402

                        90
                ....*....|....*.
gi 68303809 654 ECGKAFKWSSTLTKHK 669
Cdd:COG5189 403 VCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
553-577 5.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 5.02e-04
                          10        20
                  ....*....|....*....|....*
gi 68303809   553 LTKHKRIHTGEKPYKCEECGKAFTQ 577
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 604-697 7.22e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 7.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 604 TQSSNLTThkkihTGGKPYKCE--ECGKAFNQFSTLTKHKIiHTEEKPYKCEecgkafkwSSTLTKHKIIHTGEKPYKCE 681
Cdd:COG5189 337 TPSRMLKV-----KDGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHE--------NPSPEKMNIFSAKDKPYRCE 402

                        90
                ....*....|....*.
gi 68303809 682 ECGKAFKLSSTLSTHK 697
Cdd:COG5189 403 VCDKRYKNLNGLKYHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
733-794 8.08e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 8.08e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 68303809 733 PYKCEECGKAFNYSSHLNTHKRIHTKEQPYKC--KECGKAFNQYSNLTTHNKIHTGEKLYKPED 794
Cdd:COG5048  33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSK 96
zf-H2C2_2 pfam13465
Zinc-finger double domain;
329-353 1.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|....*
gi 68303809   329 LTKHKRIHTGEKPYTCEECGKAFNQ 353
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 646-726 1.32e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 646 EEKPYKCE--ECGKAFKWSSTLTKHKiihtgekpyKCEECGKAFKLSSTLSTHKIIHTGEKPYKCEKCGKAFNRSSNLIE 723
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ...
gi 68303809 724 HKK 726
Cdd:COG5189 417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
468-493 1.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.34e-03
                          10        20
                  ....*....|....*....|....*.
gi 68303809   468 NLTTHKRIHTAEKPYKCEECGKAFSR 493
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
748-773 1.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.73e-03
                          10        20
                  ....*....|....*....|....*.
gi 68303809   748 HLNTHKRIHTKEQPYKCKECGKAFNQ 773
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
525-549 2.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.04e-03
                          10        20
                  ....*....|....*....|....*
gi 68303809   525 LTEHKITHTGEKPYKCEECGKAFNH 549
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
608-633 2.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.04e-03
                          10        20
                  ....*....|....*....|....*.
gi 68303809   608 NLTTHKKIHTGGKPYKCEECGKAFNQ 633
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
384-408 2.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.15e-03
                          10        20
                  ....*....|....*....|....*
gi 68303809   384 NLTKHKKIHTEKKPYKCEECGKAFK 408
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
441-465 2.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.15e-03
                          10        20
                  ....*....|....*....|....*
gi 68303809   441 LTKHNRIHTGEKPYKCEVCGKAFNQ 465
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
720-745 2.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.19e-03
                          10        20
                  ....*....|....*....|....*.
gi 68303809   720 NLIEHKKIHTGEQPYKCEECGKAFNY 745
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
300-324 2.37e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.37e-03
                          10        20
                  ....*....|....*....|....*
gi 68303809   300 NLTEHKKIHPGEKPYKCEECGKAFN 324
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
580-605 2.51e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.51e-03
                          10        20
                  ....*....|....*....|....*.
gi 68303809   580 NLTTHKKIHTGEKFYKCEECGKAFTQ 605
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
665-688 2.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.80e-03
                          10        20
                  ....*....|....*....|....
gi 68303809   665 LTKHKIIHTGEKPYKCEECGKAFK 688
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 338-421 2.88e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.88e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 338 GEKPYTCE--ECGKAFNQFSNLTTHKrihtaekfyKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTE 415
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ....*.
gi 68303809 416 HKlTHT 421
Cdd:COG5189 417 HR-KHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
693-717 4.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.19e-03
                          10        20
                  ....*....|....*....|....*
gi 68303809   693 LSTHKIIHTGEKPYKCEKCGKAFNR 717
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
413-436 4.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.66e-03
                          10        20
                  ....*....|....*....|....
gi 68303809   413 LTEHKLTHTGEKPYKCEECGKAFN 436
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 450-533 8.19e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 8.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68303809 450 GEKPYKCEV--CGKAFNQFSNLTTHKRI-HTAEK--PYKCEECGKAFSrssnltkhkkihIEKKPYKCEECGKAFKWSSK 524
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQKlhENPSPEKMNIFS------------AKDKPYRCEVCDKRYKNLNG 413


                ....*....
gi 68303809 525 LTEHkITHT 533
Cdd:COG5189 414 LKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
637-660 9.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.84e-03
                          10        20
                  ....*....|....*....|....
gi 68303809   637 LTKHKIIHTEEKPYKCEECGKAFK 660
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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