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Conserved domains on  [gi|4759088|ref|NP_004197|]
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vesicle-trafficking protein SEC22c isoform b [Homo sapiens]

Protein Classification

longin domain-containing protein( domain architecture ID 13000475)

longin domain-containing protein such as synaptobrevin family proteins, Arabidopsis thaliana phytolongin and mammalian vesicle-trafficking protein SEC2, which are involved in membrane-trafficking and vesicle transport, respectively

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Longin cd14824
longin domain; Longin-domain is N-terminal domain of a subgroup of R-SNARE proteins, including ...
 5-121 1.04e-15

longin domain; Longin-domain is N-terminal domain of a subgroup of R-SNARE proteins, including VAMP7, Ykt6, and Sec22. Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex. Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterized by a conserved N-terminal domain with a profilin-like fold called a longin domain.


:

Pssm-ID: 341428  Cd Length: 122  Bit Score: 71.13  E-value: 1.04e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759088    5 FFACVVRVRDGLPLSASTDFYHTQDFLEWRRRL-KSLALRLAQYPGRGSAEGCDFSIHFSSFGDVACMAICSCQCPAAMA 83
Cdd:cd14824   1 LYALIARGSDGLILAEYTDLSSFSSVKENFKFVaKTILERTPPSGQRQSVEEGDYVFHYLVEDGLCYLCITDKEYPKRVA 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 4759088   84 FCFLETLWWEFTASYDTTCIGlASRPYAFLEFDSIIQK 121
Cdd:cd14824  81 FAFLEEVLDEFLSKYGSSAWT-AARPYLFSEFDPELKK 117
 
Name Accession Description Interval E-value
Longin cd14824
longin domain; Longin-domain is N-terminal domain of a subgroup of R-SNARE proteins, including ...
 5-121 1.04e-15

longin domain; Longin-domain is N-terminal domain of a subgroup of R-SNARE proteins, including VAMP7, Ykt6, and Sec22. Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex. Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterized by a conserved N-terminal domain with a profilin-like fold called a longin domain.


Pssm-ID: 341428  Cd Length: 122  Bit Score: 71.13  E-value: 1.04e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759088    5 FFACVVRVRDGLPLSASTDFYHTQDFLEWRRRL-KSLALRLAQYPGRGSAEGCDFSIHFSSFGDVACMAICSCQCPAAMA 83
Cdd:cd14824   1 LYALIARGSDGLILAEYTDLSSFSSVKENFKFVaKTILERTPPSGQRQSVEEGDYVFHYLVEDGLCYLCITDKEYPKRVA 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 4759088   84 FCFLETLWWEFTASYDTTCIGlASRPYAFLEFDSIIQK 121
Cdd:cd14824  81 FAFLEEVLDEFLSKYGSSAWT-AARPYLFSEFDPELKK 117
Longin pfam13774
Regulated-SNARE-like domain; Longin is one of the approximately 26 components required for ...
 38-117 6.45e-13

Regulated-SNARE-like domain; Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex. Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterized by a conserved N-terminal domain with a profilin-like fold called a longin domain.


Pssm-ID: 463978  Cd Length: 81  Bit Score: 62.56  E-value: 6.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759088     38 KSLALRLAQYPGRGSAEGCDFSIHFSSFGDVACMAICSCQCPAAMAFCFLETLWWEFTASYDTTcIGLASRPYAF-LEFD 116
Cdd:pfam13774   2 KTILEKIPQNPQRQTYEGDNYTFHYLIEDGLTYLVIADKSYPRRLAFAFLEEIKDEFLSTYGPW-TASALRPYAFnKEFD 80


                  .
gi 4759088    117 S 117
Cdd:pfam13774  81 T 81
 
Name Accession Description Interval E-value
Longin cd14824
longin domain; Longin-domain is N-terminal domain of a subgroup of R-SNARE proteins, including ...
 5-121 1.04e-15

longin domain; Longin-domain is N-terminal domain of a subgroup of R-SNARE proteins, including VAMP7, Ykt6, and Sec22. Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex. Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterized by a conserved N-terminal domain with a profilin-like fold called a longin domain.


Pssm-ID: 341428  Cd Length: 122  Bit Score: 71.13  E-value: 1.04e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759088    5 FFACVVRVRDGLPLSASTDFYHTQDFLEWRRRL-KSLALRLAQYPGRGSAEGCDFSIHFSSFGDVACMAICSCQCPAAMA 83
Cdd:cd14824   1 LYALIARGSDGLILAEYTDLSSFSSVKENFKFVaKTILERTPPSGQRQSVEEGDYVFHYLVEDGLCYLCITDKEYPKRVA 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 4759088   84 FCFLETLWWEFTASYDTTCIGlASRPYAFLEFDSIIQK 121
Cdd:cd14824  81 FAFLEEVLDEFLSKYGSSAWT-AARPYLFSEFDPELKK 117
Longin pfam13774
Regulated-SNARE-like domain; Longin is one of the approximately 26 components required for ...
 38-117 6.45e-13

Regulated-SNARE-like domain; Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex. Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterized by a conserved N-terminal domain with a profilin-like fold called a longin domain.


Pssm-ID: 463978  Cd Length: 81  Bit Score: 62.56  E-value: 6.45e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759088     38 KSLALRLAQYPGRGSAEGCDFSIHFSSFGDVACMAICSCQCPAAMAFCFLETLWWEFTASYDTTcIGLASRPYAF-LEFD 116
Cdd:pfam13774   2 KTILEKIPQNPQRQTYEGDNYTFHYLIEDGLTYLVIADKSYPRRLAFAFLEEIKDEFLSTYGPW-TASALRPYAFnKEFD 80


                  .
gi 4759088    117 S 117
Cdd:pfam13774  81 T 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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