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Conserved domains on  [gi|4757714|ref|NP_004291|]
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low molecular weight phosphotyrosine protein phosphatase isoform c [Homo sapiens]

Protein Classification

low molecular weight protein-tyrosine-phosphatase( domain architecture ID 11611401)

low molecular weight protein-tyrosine-phosphatase is a small soluble single-domain enzyme that catalyzes the dephosphorylation of O-phosphotyrosine groups in phosphoproteins

EC:  3.1.3.48
Gene Ontology:  GO:0004725|GO:0006470
PubMed:  12678841|12882518|27676368
SCOP:  4000436

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 7-155 2.87e-82

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


:

Pssm-ID: 319971  Cd Length: 147  Bit Score: 238.88  E-value: 2.87e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757714    7 KSVLFVCLGNICRSPIAEAVFRKLVTDQNiSENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMS-HVARQITKEDFAT 85
Cdd:cd16343   1 KKILFVCLGNICRSPMAEAVLRHLLPKAG-GDDVEVDSAGTSAWHGGEPPDPRARAVLKEHGIDLSgHRARQLTAEDFDE 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757714   86 FDYILCMDESNLRDLNRKSNqvKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLE 155
Cdd:cd16343  80 FDLILAMDESNLRDLRRLAP--AEARGKVFLLGDFDPEGGKDVPDPYYGGREGFEEVYDLIERACEGLLE 147
 
Name Accession Description Interval E-value
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 7-155 2.87e-82

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


Pssm-ID: 319971  Cd Length: 147  Bit Score: 238.88  E-value: 2.87e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757714    7 KSVLFVCLGNICRSPIAEAVFRKLVTDQNiSENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMS-HVARQITKEDFAT 85
Cdd:cd16343   1 KKILFVCLGNICRSPMAEAVLRHLLPKAG-GDDVEVDSAGTSAWHGGEPPDPRARAVLKEHGIDLSgHRARQLTAEDFDE 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757714   86 FDYILCMDESNLRDLNRKSNqvKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLE 155
Cdd:cd16343  80 FDLILAMDESNLRDLRRLAP--AEARGKVFLLGDFDPEGGKDVPDPYYGGREGFEEVYDLIERACEGLLE 147
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
9-154 2.76e-65

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 195.67  E-value: 2.76e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757714      9 VLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYeIGNPPDYRGQSCMKRHGIPMS-HVARQITKEDFATFD 87
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKAGLGDKVEVDSAGTGAW-PGNPADPRAVEVLKEHGIDLSgHYARQLSTEDFASFD 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4757714     88 YILCMDESNLRDLNRKSNQvkTCKAKIELLGSYdpQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFL 154
Cdd:pfam01451  80 LILAMDSEHKRDLCPLAPE--RYRAKVMLLGEY--GEQLDIPDPYYGSIDAFEEVRDLIERRCRQLL 142
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
6-156 9.62e-48

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 151.08  E-value: 9.62e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757714    6 TKSVLFVCLGNICRSPIAEAVFRKLVtdqniSENWRVDSAATSGyeiGNPPDYRGQSCMKRHGIPMS-HVARQITKEDFA 84
Cdd:COG0394   3 PKRVLFVCTGNICRSPMAEALLRHLA-----GGRVEVDSAGTEP---GGPVDPRAVAVLAERGIDLSgHRSRQLDEEDLP 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4757714   85 TFDYILCMDESNLRDLnrksnqVKTCKAKIELLGSYDpqkqliIEDPYYGNDSDFETVYQQCVRCCRAFLEK 156
Cdd:COG0394  75 EFDLVITMCDSAAEEL------CPLFPGAAKLLLHWD------VPDPYYGGLEAFREVRDEIERRIEALLAK 134
LMWPc smart00226
Low molecular weight phosphatase family;
9-155 4.77e-43

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 139.14  E-value: 4.77e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757714       9 VLFVCLGNICRSPIAEAVFRKLVTDqniseNWRVDSAATSGYeIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDY 88
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYVGD-----RVKIDSAGTGAW-VGGGADPRAVKVLKEHGIDLSHHASQLTSSDFKNADL 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4757714      89 ILCMDESNLRDLNRKSNQVktcKAKIELLGSYDpqkqlIIEDPYYGNDSDFETVYQQCVRCCRAFLE 155
Cdd:smart00226  75 VLAMDGSHLRNICRLKPPS---RAKVELFGHYV-----DVDDPYYGGIDGFERVYDELENALQEFLK 133
etp PRK11391
phosphotyrosine-protein phosphatase; Provisional
 8-143 2.13e-18

phosphotyrosine-protein phosphatase; Provisional


Pssm-ID: 138553  Cd Length: 144  Bit Score: 76.60  E-value: 2.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757714     8 SVLFVCLGNICRSPIAEAVFRKLVTdqniseNWRVDSAATSGYeIGNPPDYRGQSCMKRHGIPMS-HVARQITKEDFATF 86
Cdd:PRK11391   4 SILVVCTGNICRSPIGERLLRKRLP------GVKVKSAGVHGL-VKHPADATAADVAANHGVSLEgHAGRKLTAEMARNY 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 4757714    87 DYILCMDESNLRDLNRKSNQVktcKAKIELLGSYDPQKQliIEDPYYGNDSDFETVY 143
Cdd:PRK11391  77 DLILAMESEHIAQVTAIAPEV---RGKTMLFGQWLEQKE--IPDPYRKSQDAFEHVY 128
 
Name Accession Description Interval E-value
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 7-155 2.87e-82

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


Pssm-ID: 319971  Cd Length: 147  Bit Score: 238.88  E-value: 2.87e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757714    7 KSVLFVCLGNICRSPIAEAVFRKLVTDQNiSENWRVDSAATSGYEIGNPPDYRGQSCMKRHGIPMS-HVARQITKEDFAT 85
Cdd:cd16343   1 KKILFVCLGNICRSPMAEAVLRHLLPKAG-GDDVEVDSAGTSAWHGGEPPDPRARAVLKEHGIDLSgHRARQLTAEDFDE 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757714   86 FDYILCMDESNLRDLNRKSNqvKTCKAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLE 155
Cdd:cd16343  80 FDLILAMDESNLRDLRRLAP--AEARGKVFLLGDFDPEGGKDVPDPYYGGREGFEEVYDLIERACEGLLE 147
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
9-154 2.76e-65

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 195.67  E-value: 2.76e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757714      9 VLFVCLGNICRSPIAEAVFRKLVTDQNISENWRVDSAATSGYeIGNPPDYRGQSCMKRHGIPMS-HVARQITKEDFATFD 87
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKAGLGDKVEVDSAGTGAW-PGNPADPRAVEVLKEHGIDLSgHYARQLSTEDFASFD 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4757714     88 YILCMDESNLRDLNRKSNQvkTCKAKIELLGSYdpQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFL 154
Cdd:pfam01451  80 LILAMDSEHKRDLCPLAPE--RYRAKVMLLGEY--GEQLDIPDPYYGSIDAFEEVRDLIERRCRQLL 142
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
6-156 9.62e-48

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 151.08  E-value: 9.62e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757714    6 TKSVLFVCLGNICRSPIAEAVFRKLVtdqniSENWRVDSAATSGyeiGNPPDYRGQSCMKRHGIPMS-HVARQITKEDFA 84
Cdd:COG0394   3 PKRVLFVCTGNICRSPMAEALLRHLA-----GGRVEVDSAGTEP---GGPVDPRAVAVLAERGIDLSgHRSRQLDEEDLP 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4757714   85 TFDYILCMDESNLRDLnrksnqVKTCKAKIELLGSYDpqkqliIEDPYYGNDSDFETVYQQCVRCCRAFLEK 156
Cdd:COG0394  75 EFDLVITMCDSAAEEL------CPLFPGAAKLLLHWD------VPDPYYGGLEAFREVRDEIERRIEALLAK 134
LMWPc smart00226
Low molecular weight phosphatase family;
9-155 4.77e-43

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 139.14  E-value: 4.77e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757714       9 VLFVCLGNICRSPIAEAVFRKLVTDqniseNWRVDSAATSGYeIGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFDY 88
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYVGD-----RVKIDSAGTGAW-VGGGADPRAVKVLKEHGIDLSHHASQLTSSDFKNADL 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4757714      89 ILCMDESNLRDLNRKSNQVktcKAKIELLGSYDpqkqlIIEDPYYGNDSDFETVYQQCVRCCRAFLE 155
Cdd:smart00226  75 VLAMDGSHLRNICRLKPPS---RAKVELFGHYV-----DVDDPYYGGIDGFERVYDELENALQEFLK 133
LMWP cd00115
Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group ...
 8-155 2.14e-38

Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group of small soluble enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). This family includes protein tyrosine phosphatases, arginine phosphatases and arsenate reductases.


Pssm-ID: 319970  Cd Length: 137  Bit Score: 127.61  E-value: 2.14e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757714    8 SVLFVCLGNICRSPIAEAVFRKLVTDQnisenWRVDSAATSGYEiGNPPDYRGQSCMKRHGIPMSHVARQITKEDFATFD 87
Cdd:cd00115   1 SILFICTGNICRSPMAEAIFKQLLGDE-----WKVDSAGTGAHH-GEGADPRAVRVLKEVGIDISHRSDQIKSEHLDNYD 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4757714   88 YILCMDESNLRDLNRKSNQvktckAKIELLGSYDPQKQLIIEDPYYGNDSDFETVYQQCVRCCRAFLE 155
Cdd:cd00115  75 LVLVMDGSNLDKIPRIFPE-----ARGKTWLPHVKLEHGEIDDPYRGDIEDFRRVRDELENASKRFAE 137
LMWPAP cd16344
low molecular weight protein arginine phosphatase; Low molecular weight protein arginine ...
 7-146 1.04e-24

low molecular weight protein arginine phosphatase; Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.


Pssm-ID: 319972  Cd Length: 142  Bit Score: 92.50  E-value: 1.04e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757714    7 KSVLFVCLGNICRSPIAEAVFRKLVTDQNISenwrVDSAATSGYEiGNPPDYRGQSCMKRHGIPMS-HVARQITKEDFAT 85
Cdd:cd16344   1 MKILFVCTGNTCRSPMAEAILKKLLEELDVE----VKSAGIFAVD-GSPASPNAVEVLKEKGIDLSgHRSQQLTEELLEW 75

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4757714   86 FDYILCMDESNLRDLnrkSNQVKTCKAKIELLGSYDPQKQLIIEDPYYGndsDFEtVYQQC 146
Cdd:cd16344  76 ADLILTMTESHKQAL---LSLYPEAADKVFTLKEYVGGEDGDISDPFGG---SLE-VYRQT 129
etp PRK11391
phosphotyrosine-protein phosphatase; Provisional
 8-143 2.13e-18

phosphotyrosine-protein phosphatase; Provisional


Pssm-ID: 138553  Cd Length: 144  Bit Score: 76.60  E-value: 2.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757714     8 SVLFVCLGNICRSPIAEAVFRKLVTdqniseNWRVDSAATSGYeIGNPPDYRGQSCMKRHGIPMS-HVARQITKEDFATF 86
Cdd:PRK11391   4 SILVVCTGNICRSPIGERLLRKRLP------GVKVKSAGVHGL-VKHPADATAADVAANHGVSLEgHAGRKLTAEMARNY 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 4757714    87 DYILCMDESNLRDLNRKSNQVktcKAKIELLGSYDPQKQliIEDPYYGNDSDFETVY 143
Cdd:PRK11391  77 DLILAMESEHIAQVTAIAPEV---RGKTMLFGQWLEQKE--IPDPYRKSQDAFEHVY 128
PRK10126 PRK10126
low molecular weight protein-tyrosine-phosphatase Wzb;
9-151 6.76e-15

low molecular weight protein-tyrosine-phosphatase Wzb;


Pssm-ID: 182256  Cd Length: 147  Bit Score: 67.24  E-value: 6.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757714     9 VLFVCLGNICRSPIAEAVFrklvtdQNISENWRVDSAATsGYEIGNPPDYRGQSCMKRHGIPM-SHVARQITKEDFATFD 87
Cdd:PRK10126   5 ILVVCVGNICRSPTAERLL------QRYHPELKVESAGL-GALVGKGADPTAISVAAEHQLSLeGHCARQISRRLCRNYD 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4757714    88 YILCMDESNLRDLNRKSNQVktcKAKIELLGSYDPQKQliIEDPYYGNDSDFETVYQQCVRCCR 151
Cdd:PRK10126  78 LILTMEKRHIERLCEMAPEM---RGKVMLFGHWDNECE--IPDPYRKSREAFEAVYTLLERSAR 136
LMWP_ArsC cd16345
Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the ...
 9-91 1.21e-08

Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).


Pssm-ID: 319973  Cd Length: 132  Bit Score: 50.53  E-value: 1.21e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757714    9 VLFVCLGNICRSPIAEAVFRKLVtdqniSENWRVDSAATSGYEIgNPpdyRGQSCMKRHGIPMSHvarQITK--EDFA-- 84
Cdd:cd16345   2 VLFLCTGNSARSQMAEALLRHLG-----GDRFEAYSAGSEPAGV-NP---LAIEVMKEIGIDISG---QRSKslDEFLgq 69


                ....*....
gi 4757714   85 TFDYI--LC 91
Cdd:cd16345  70 EFDYVitVC 78
COG4551 COG4551
Predicted protein tyrosine phosphatase [General function prediction only];
6-103 1.14e-05

Predicted protein tyrosine phosphatase [General function prediction only];


Pssm-ID: 443615  Cd Length: 109  Bit Score: 42.13  E-value: 1.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757714    6 TKSVLFVCLGNICRSPIAEAVFRKlvtdqniSENWRVDSAATSgyeignpPDYRgqscmkrhgipmshvaRQITKEDFAT 85
Cdd:COG4551   1 MMNVLFVCSRNRWRSPTAEQVFRN-------HPGVEVRSAGTS-------PDAR----------------VPVTAELIEW 50

                        90
                ....*....|....*...
gi 4757714   86 FDYILCMDESNLRDLNRK 103
Cdd:COG4551  51 ADVIFVMEKKHRNRLSKR 68
PRK13530 PRK13530
arsenate reductase (thioredoxin);
7-73 2.11e-03

arsenate reductase (thioredoxin);


Pssm-ID: 237415  Cd Length: 133  Bit Score: 36.26  E-value: 2.11e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4757714     7 KSVLFVCLGNICRSPIAEAVFRKLVTDQnisenWRVDSAATSGYEIgNPPDYRGqscMKRHGIPMSH 73
Cdd:PRK13530   4 KTIYFLCTGNSCRSQMAEGWGKQYLGDK-----WNVYSAGIEAHGV-NPNAIKA---MKEVGIDISN 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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