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Conserved domains on  [gi|4757766|ref|NP_004299|]
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rho GTPase-activating protein 1 [Homo sapiens]

Protein Classification

CRAL-TRIO domain-containing protein( domain architecture ID 10617207)

CRAL-TRIO domain-containing protein act as a lipid binding protein which may bind small lipophilic molecules such as retinal, inositol, and vitamin E

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 239-431 3.01e-124

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 358.57  E-value: 3.01e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  239 NQQFGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVIL 318
Cdd:cd04404   3 TQQFGVSLQFLKEKNPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVIL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  319 KTFLRELPEPLLTFDLYPHVVGFLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGP 398
Cdd:cd04404  83 KTFLRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGP 162

                       170       180       190
                ....*....|....*....|....*....|...
gi 4757766  399 NLLWAKDAAITLKAINPINTFTKFLLDHQGELF 431
Cdd:cd04404 163 NLLWAKDASMSLSAINPINTFTKFLLDHQDEIF 195
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
 82-216 3.25e-30

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


:

Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 113.96  E-value: 3.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766     82 GRKIIVFSACRMP--PSHQLDHSKLLGYLKHTLDQYVES-DYTLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKAL 158
Cdd:pfam13716   1 GRPVLVFISKLLPsrPASLDDLDRLLFYLLKTLSEKLKGkPFVVVVDHTGVTSENFPSLSFLKKAYDLLPRAFKKNLKAV 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4757766    159 YIVHPTMFIKTLL-ILFKPLISFKFGQKIFYVNYLSELSEHVKLEQL--GIPrQVLKYDDF 216
Cdd:pfam13716  81 YVVHPSTFLRTFLkTLGSLLGSKKLRKKVHYVSSLSELWEGIDREQLptELP-GVLSYDEE 140
 
Name Accession Description Interval E-value
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 239-431 3.01e-124

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 358.57  E-value: 3.01e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  239 NQQFGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVIL 318
Cdd:cd04404   3 TQQFGVSLQFLKEKNPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVIL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  319 KTFLRELPEPLLTFDLYPHVVGFLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGP 398
Cdd:cd04404  83 KTFLRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGP 162

                       170       180       190
                ....*....|....*....|....*....|...
gi 4757766  399 NLLWAKDAAITLKAINPINTFTKFLLDHQGELF 431
Cdd:cd04404 163 NLLWAKDASMSLSAINPINTFTKFLLDHQDEIF 195
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 258-427 1.60e-52

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 173.99  E-value: 1.60e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766     258 PIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFD-QYNELHLPAVILKTFLRELPEPLLTFDLYP 336
Cdd:smart00324   2 PIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDlSEYDVHDVAGLLKLFLRELPEPLITYELYE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766     337 HVVGFLNI-DESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWAKD-AAITLKAIN 414
Cdd:smart00324  82 EFIEAAKLeDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDgEVASLKDIR 161

                          170
                   ....*....|...
gi 4757766     415 PINTFTKFLLDHQ 427
Cdd:smart00324 162 HQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 260-405 2.29e-52

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 172.73  E-value: 2.29e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766    260 PIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMG-LPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHV 338
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGpDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4757766    339 VGFLNI-DESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWAKD 405
Cdd:pfam00620  81 IEAAKLpDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
 82-216 3.25e-30

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 113.96  E-value: 3.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766     82 GRKIIVFSACRMP--PSHQLDHSKLLGYLKHTLDQYVES-DYTLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKAL 158
Cdd:pfam13716   1 GRPVLVFISKLLPsrPASLDDLDRLLFYLLKTLSEKLKGkPFVVVVDHTGVTSENFPSLSFLKKAYDLLPRAFKKNLKAV 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4757766    159 YIVHPTMFIKTLL-ILFKPLISFKFGQKIFYVNYLSELSEHVKLEQL--GIPrQVLKYDDF 216
Cdd:pfam13716  81 YVVHPSTFLRTFLkTLGSLLGSKKLRKKVHYVSSLSELWEGIDREQLptELP-GVLSYDEE 140
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
 66-215 7.30e-25

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 99.68  E-value: 7.30e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766      66 DIARHQIVEVAGDDKYGRKIIVFSACRMPPsHQLDHSKLLGYLKHTLDQYVES---DYTLLYLHHGLTSDNKPS----LS 138
Cdd:smart00516   3 ELLKAYIPGGRGYDKDGRPVLIERAGRFDL-KSVTLEELLRYLVYVLEKILQEekkTGGIEGFTVIFDLKGLSMsnpdLS 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4757766     139 WLRDAYREFDRKYKKNIKALYIVHPTMFIKTLLILFKPLISFKFGQKIFYV--NYLSELSEHVKLEQLgiPRQVLKYDD 215
Cdd:smart00516  82 VLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVgnDSKEELLEYIDKEQL--PEELGGTLD 158
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 77-204 1.49e-22

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 93.55  E-value: 1.49e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766   77 GDDKYGRKIIVFSAcRMPPSHQLDHSKLLGYLKHTLDQYVESDY------TLLYLHHGLTSDNKPSLSWLRDAYREFDRK 150
Cdd:cd00170  16 GRDKEGRPVLVFRA-GWDPPKLLDLEELLRYLVYLLEKALRELEeqvegfVVIIDLKGFSLSNLSDLSLLKKLLKILQDH 94

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 4757766  151 YKKNIKALYIVHPTMFIKTLLILFKPLISFKFGQKIFYVNY-LSELSEHVKLEQL 204
Cdd:cd00170  95 YPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSdLEELLEYIDPDQL 149
 
Name Accession Description Interval E-value
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 239-431 3.01e-124

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 358.57  E-value: 3.01e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  239 NQQFGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVIL 318
Cdd:cd04404   3 TQQFGVSLQFLKEKNPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVIL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  319 KTFLRELPEPLLTFDLYPHVVGFLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGP 398
Cdd:cd04404  83 KTFLRELPEPLLTFDLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGP 162

                       170       180       190
                ....*....|....*....|....*....|...
gi 4757766  399 NLLWAKDAAITLKAINPINTFTKFLLDHQGELF 431
Cdd:cd04404 163 NLLWAKDASMSLSAINPINTFTKFLLDHQDEIF 195
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 258-427 1.60e-52

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 173.99  E-value: 1.60e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766     258 PIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFD-QYNELHLPAVILKTFLRELPEPLLTFDLYP 336
Cdd:smart00324   2 PIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDlSEYDVHDVAGLLKLFLRELPEPLITYELYE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766     337 HVVGFLNI-DESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWAKD-AAITLKAIN 414
Cdd:smart00324  82 EFIEAAKLeDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDgEVASLKDIR 161

                          170
                   ....*....|...
gi 4757766     415 PINTFTKFLLDHQ 427
Cdd:smart00324 162 HQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 260-405 2.29e-52

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 172.73  E-value: 2.29e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766    260 PIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMG-LPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHV 338
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGpDVDLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4757766    339 VGFLNI-DESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWAKD 405
Cdd:pfam00620  81 IEAAKLpDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 260-426 7.53e-51

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 169.40  E-value: 7.53e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  260 PIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDLYPHVV 339
Cdd:cd00159   1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  340 GFLNI-DESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWAKDAAITLKA-INPIN 417
Cdd:cd00159  81 ELAKIeDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLRPPDSDDELLEdIKKLN 160


                ....*....
gi 4757766  418 TFTKFLLDH 426
Cdd:cd00159 161 EIVEFLIEN 169
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 240-432 6.08e-40

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 141.83  E-value: 6.08e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  240 QQFGVSLQ-HLQEKNPEqepIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMG---LPVDfDQYNELHLPA 315
Cdd:cd04386   3 PVFGTPLEeHLKRTGRE---IALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAGtfsLPLD-EFYSDPHAVA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  316 VILKTFLRELPEPLLTFDLYPHVVGFLNI-DESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAV 394
Cdd:cd04386  79 SALKSYLRELPDPLLTYNLYEDWVQAANKpDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNIAI 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 4757766  395 VFGPNLLWAK-DAAITLKAINP---INTFTKFLLDHQGELFP 432
Cdd:cd04386 159 VLAPNLLWAKnEGSLAEMAAGTsvhVVAIVELIISHADWFFP 200
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-431 6.66e-36

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 130.88  E-value: 6.66e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQHL-QEKNPeqePIPIVlrETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNeLHLPAVILKT 320
Cdd:cd04402   2 FGQPLSNIcEDDNL---PKPIL--DMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLKAEP-VLLLASVLKD 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  321 FLRELPEPLLTFDLYPHVVGFLNI-DESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPN 399
Cdd:cd04402  76 FLRNIPGSLLSSDLYEEWMSALDQeNEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPS 155

                       170       180       190
                ....*....|....*....|....*....|....
gi 4757766  400 LLWaKDAAITLKA--INPINTFTKFLLDHQGELF 431
Cdd:cd04402 156 LLW-PPASSELQNedLKKVTSLVQFLIENCQEIF 188
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-425 1.89e-34

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 126.81  E-value: 1.89e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTF 321
Cdd:cd04393   3 FGVPLQELQQAGQPENGVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLLRLF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  322 LRELPEPLLTFDLYPHVV----GFLNIDESQRvpATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFG 397
Cdd:cd04393  83 LQELPEGLIPASLQIRLMqlyqDYNGEDEFGR--KLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLAAVFG 160

                       170       180
                ....*....|....*....|....*...
gi 4757766  398 PNLLWAKDAAITLKAINPINTFTKFLLD 425
Cdd:cd04393 161 PDVFHVYTDVEDMKEQEICSRIMAKLLE 188
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 242-420 5.63e-33

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 122.93  E-value: 5.63e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQHLQEknpEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGL-PVDFDQYNeLHLPAVILKT 320
Cdd:cd04377   1 FGVSLSSLTS---EDRSVPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDPdSVNLEDYP-IHVITSVLKQ 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  321 FLRELPEPLLTFDLYPHVVGFLNIDESQ-RVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPN 399
Cdd:cd04377  77 WLRELPEPLMTFELYENFLRAMELEEKQeRVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIVFAPC 156

                       170       180
                ....*....|....*....|.
gi 4757766  400 LLWAKDAAITLKAINPINTFT 420
Cdd:cd04377 157 ILRCPDTADPLQSLQDVSKTT 177
CRAL_TRIO_2 pfam13716
Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain ...
 82-216 3.25e-30

Divergent CRAL/TRIO domain; This family includes divergent members of the CRAL-TRIO domain family. This family includes ECM25 that contains a divergent CRAL-TRIO domain identified by Gallego and colleagues.


Pssm-ID: 463965 [Multi-domain]  Cd Length: 140  Bit Score: 113.96  E-value: 3.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766     82 GRKIIVFSACRMP--PSHQLDHSKLLGYLKHTLDQYVES-DYTLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKAL 158
Cdd:pfam13716   1 GRPVLVFISKLLPsrPASLDDLDRLLFYLLKTLSEKLKGkPFVVVVDHTGVTSENFPSLSFLKKAYDLLPRAFKKNLKAV 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4757766    159 YIVHPTMFIKTLL-ILFKPLISFKFGQKIFYVNYLSELSEHVKLEQL--GIPrQVLKYDDF 216
Cdd:pfam13716  81 YVVHPSTFLRTFLkTLGSLLGSKKLRKKVHYVSSLSELWEGIDREQLptELP-GVLSYDEE 140
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-401 1.58e-28

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 111.41  E-value: 1.58e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQHLQEKN-PEQEPIPIVLRETVAYLQAHaLTTEGIFRRSANTQVVREVQQKYNMG-------LPVDFdqynelhl 313
Cdd:cd04394   2 FGVPLHSLPHSTvPEYGNVPKFLVDACTFLLDH-LSTEGLFRKSGSVVRQKELKAKLEGGeaclssaLPCDV-------- 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  314 pAVILKTFLRELPEPLLTFDLYPhvvGFLNIDE----SQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTN 389
Cdd:cd04394  73 -AGLLKQFFRELPEPLLPYDLHE---ALLKAQElptdEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVAQRCSENKMDS 148

                       170
                ....*....|..
gi 4757766  390 TNLAVVFGPNLL 401
Cdd:cd04394 149 SNLAVIFAPNLF 160
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 242-425 3.20e-28

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 110.14  E-value: 3.20e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQHLQEKNPEQE---PIPIVLRETVAYL-QAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNE---LHLP 314
Cdd:cd04400   2 FGSPLEEAVELSSHKYngrDLPSVVYRCIEYLdKNRAIYEEGIFRLSGSASVIKQLKERFNTEYDVDLFSSSLypdVHTV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  315 AVILKTFLRELPEPLLTFDLYPHV--VGFLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNL 392
Cdd:cd04400  82 AGLLKLYLRELPTLILGGELHNDFkrLVEENHDRSQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNLRNV 161

                       170       180       190
                ....*....|....*....|....*....|...
gi 4757766  393 AVVFGPNLlwakdaAItlkainPINTFTKFLLD 425
Cdd:cd04400 162 CIVFSPTL------NI------PAGIFVLFLTD 182
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 243-431 5.65e-28

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 109.84  E-value: 5.65e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  243 GVSLQHLQ-----EKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVI 317
Cdd:cd04390   1 GVFGQRLEdtvayERKFGPRLVPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTDVHTVASL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  318 LKTFLRELPEPLLTFDLYPHVVG---FLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAV 394
Cdd:cd04390  81 LKLYLRELPEPVIPWAQYEDFLScaqLLSKDEEKGLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLAT 160

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 4757766  395 VFGPNLLWAK--DAAITLKAINPINTFTKFLLDHQGELF 431
Cdd:cd04390 161 VFGPNILRPKveDPATIMEGTPQIQQLMTVMISKHEPLF 199
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-401 1.22e-27

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 108.64  E-value: 1.22e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQHLQEKnpEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQ-------KYNMGLPVDFDqyNELHLP 314
Cdd:cd04398   1 FGVPLEDLILR--EGDNVPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKElfdkdplNVLLISPEDYE--SDIHSV 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  315 AVILKTFLRELPEPLLTFDLYPHVVGFLNI-DESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLA 393
Cdd:cd04398  77 ASLLKLFFRELPEPLLTKALSREFIEAAKIeDESRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVNRMSVNNLA 156


                ....*...
gi 4757766  394 VVFGPNLL 401
Cdd:cd04398 157 IIWGPTLM 164
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 242-424 5.90e-27

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 106.61  E-value: 5.90e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQHLQEknpEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMG-LPVDFDQYnELHLPAVILKT 320
Cdd:cd04407   1 FGVRVGSLTS---NKTSVPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADpENVKLENY-PIHAITGLLKQ 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  321 FLRELPEPLLTFDLYPHVVGFLNIDESQ-RVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPN 399
Cdd:cd04407  77 WLRELPEPLMTFAQYNDFLRAVELPEKQeQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAIVFAPC 156

                       170       180
                ....*....|....*....|....*...
gi 4757766  400 LLWAKDAA---ITLKAINPINTFTKFLL 424
Cdd:cd04407 157 LLRCPDSSdplTSMKDVAKTTTCVEMLI 184
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 253-401 7.00e-27

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 106.76  E-value: 7.00e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  253 NPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTF 332
Cdd:cd04376   3 NPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLLPR 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  333 DLYPHVVGFLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQ-----------NKMTNTNLAVVFGPNLL 401
Cdd:cd04376  83 ELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADsidedgqevsgNKMTSLNLATIFGPNLL 162
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 242-401 9.74e-27

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 105.94  E-value: 9.74e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQHLQEKnpEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFD--QYNELHLPAVILK 319
Cdd:cd04403   1 FGCHLEALCQR--ENSTVPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVDHDEKLDLDdsKWEDIHVITGALK 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  320 TFLRELPEPLLTFDLYPHVVGFLNIDES-QRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGP 398
Cdd:cd04403  79 LFFRELPEPLFPYSLFNDFVAAIKLSDYeQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVFGP 158


                ...
gi 4757766  399 NLL 401
Cdd:cd04403 159 TLL 161
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-400 1.55e-26

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 105.56  E-value: 1.55e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQHLQEKNpEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMG---LPVDFDQYNELHLPAVIL 318
Cdd:cd04395   2 FGVPLDDCPPSS-ENPYVPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGgfdIDLQDPRWRDVNVVSSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  319 KTFLRELPEPLLTFDLYPHvvgFLNIDE----SQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAV 394
Cdd:cd04395  81 KSFFRKLPEPLFTNELYPD---FIEANRiedpVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPRNLAI 157


                ....*.
gi 4757766  395 VFGPNL 400
Cdd:cd04395 158 VFGPTL 163
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 248-409 1.14e-25

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 102.77  E-value: 1.14e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  248 HLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKY-NMGLPVDFDQyNELHLPAV--ILKTFLRE 324
Cdd:cd04385   4 ALEDQQLTDNDIPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFrKDARSVQLRE-GEYTVHDVadVLKRFLRD 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  325 LPEPLLTFDLYPHVVGFLNI-DESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWA 403
Cdd:cd04385  83 LPDPLLTSELHAEWIEAAELeNKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPTLFQT 162


                ....*.
gi 4757766  404 KDAAIT 409
Cdd:cd04385 163 DEHSVG 168
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 242-401 1.77e-25

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 102.89  E-value: 1.77e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQHLQEKNPEQepIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLP-VDFDQYNElHLPAVILKT 320
Cdd:cd04378   1 FGVDFSQVPRDFPDE--VPFIIKKCTSEIENRALGVQGIYRVSGSKARVEKLCQAFENGKDlVELSELSP-HDISSVLKL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  321 FLRELPEPLLTFDLYPHVVGFLNidESQRVPATLQ-----------------VLQTLPEENYQVLRFLTAFLVQISAHSD 383
Cdd:cd04378  78 FLRQLPEPLILFRLYNDFIALAK--EIQRDTEEDKapntpievnriirklkdLLRQLPASNYNTLQHLIAHLYRVAEQFE 155

                       170
                ....*....|....*...
gi 4757766  384 QNKMTNTNLAVVFGPNLL 401
Cdd:cd04378 156 ENKMSPNNLGIVFGPTLI 173
SEC14 smart00516
Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain ...
 66-215 7.30e-25

Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p) and in RhoGAPs, RhoGEFs and the RasGAP, neurofibromin (NF1). Lipid-binding domain. The SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 214706 [Multi-domain]  Cd Length: 158  Bit Score: 99.68  E-value: 7.30e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766      66 DIARHQIVEVAGDDKYGRKIIVFSACRMPPsHQLDHSKLLGYLKHTLDQYVES---DYTLLYLHHGLTSDNKPS----LS 138
Cdd:smart00516   3 ELLKAYIPGGRGYDKDGRPVLIERAGRFDL-KSVTLEELLRYLVYVLEKILQEekkTGGIEGFTVIFDLKGLSMsnpdLS 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4757766     139 WLRDAYREFDRKYKKNIKALYIVHPTMFIKTLLILFKPLISFKFGQKIFYV--NYLSELSEHVKLEQLgiPRQVLKYDD 215
Cdd:smart00516  82 VLRKILKILQDHYPERLGKVYIINPPWFFRVLWKIIKPFLDEKTREKIRFVgnDSKEELLEYIDKEQL--PEELGGTLD 158
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-401 2.81e-24

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 99.07  E-value: 2.81e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQHLQEKnpeQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYN-ELHLPAVILKT 320
Cdd:cd04373   1 FGVPLANVVTS---EKPIPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSKDfTVNAVAGALKS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  321 FLRELPEPLLTFDLYPHVVGFLNI-DESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPN 399
Cdd:cd04373  78 FFSELPDPLIPYSMHLELVEAAKInDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSICFWPT 157


                ..
gi 4757766  400 LL 401
Cdd:cd04373 158 LM 159
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 242-420 3.28e-23

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 96.22  E-value: 3.28e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQHLQEknpEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGL-PVDFDQYNeLHLPAVILKT 320
Cdd:cd04406   1 FGVELSRLTS---EDRSVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAnSVNLDDYN-IHVIASVFKQ 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  321 FLRELPEPLLTFDLYPHVVGFLNI-DESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPN 399
Cdd:cd04406  77 WLRDLPNPLMTFELYEEFLRAMGLqERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFAPC 156

                       170       180
                ....*....|....*....|.
gi 4757766  400 LLWAKDAAITLKAINPINTFT 420
Cdd:cd04406 157 ILRCPDTTDPLQSVQDISKTT 177
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 242-430 8.61e-23

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 95.94  E-value: 8.61e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQH----------LQEKNPEQEP---IPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYN----MGLPVD 304
Cdd:cd04396   2 FGVSLEEslkyasvaisIVDEDGEQYVygyIPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIFStppdYGKSFD 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  305 FDQYNeLHLPAVILKTFLRELPEPLLTFDLY----------PHVVGF--------LNIDESQRVPATLQVLQTLPEENYQ 366
Cdd:cd04396  82 WDGYT-VHDAASVLRRYLNNLPEPLVPLDLYeefrnplrkrPRILQYmkgrinepLNTDIDQAIKEYRDLITRLPNLNRQ 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4757766  367 VLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGEL 430
Cdd:cd04396 161 LLLYLLDLLAVFARNSDKNLMTASNLAAIFQPGILSHPDHEMDPKEYKLSRLVVEFLIEHQDKF 224
SEC14 cd00170
Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory ...
 77-204 1.49e-22

Sec14p-like lipid-binding domain; Sec14p-like lipid-binding domains are found in secretory proteins, such as S. cerevisiae phosphatidylinositol transfer protein (Sec14p), and in lipid regulated proteins such as RhoGAPs, RhoGEFs and neurofibromin (NF1). SEC14 domain of Dbl is known to associate with G protein beta/gamma subunits.


Pssm-ID: 469559 [Multi-domain]  Cd Length: 156  Bit Score: 93.55  E-value: 1.49e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766   77 GDDKYGRKIIVFSAcRMPPSHQLDHSKLLGYLKHTLDQYVESDY------TLLYLHHGLTSDNKPSLSWLRDAYREFDRK 150
Cdd:cd00170  16 GRDKEGRPVLVFRA-GWDPPKLLDLEELLRYLVYLLEKALRELEeqvegfVVIIDLKGFSLSNLSDLSLLKKLLKILQDH 94

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 4757766  151 YKKNIKALYIVHPTMFIKTLLILFKPLISFKFGQKIFYVNY-LSELSEHVKLEQL 204
Cdd:cd00170  95 YPERLKKIYIVNAPWIFSALWKIVKPFLSEKTRKKIVFLGSdLEELLEYIDPDQL 149
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 242-407 1.80e-22

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 94.84  E-value: 1.80e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKY---NMGLPVDFDQYNELHLPAVIL 318
Cdd:cd04379   1 FGVPLSRLVEREGESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFernSAAVELSEELYPDINVITGVL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  319 KTFLRELPEPLLTFDLYPHVVGFLNIDESQRVPA----TLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAV 394
Cdd:cd04379  81 KDYLRELPEPLITPQLYEMVLEALAVALPNDVQTnthlTLSIIDCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQNLAV 160

                       170
                ....*....|...
gi 4757766  395 VFGPNLLWAKDAA 407
Cdd:cd04379 161 CFGPVLMFCSQEF 173
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-400 3.97e-22

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 94.02  E-value: 3.97e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQ-HLQEKNpeqEPIPIVLRETVAYLQAHALTTEGIFRRS---ANTQVVREVQQKYNMGlpVDFDQYnELHLPAVI 317
Cdd:cd04375   5 FGVPLLvNLQRTG---QPLPRSIQQAMRWLRNNALDQVGLFRKSgvkSRIQKLRSMIESSTDN--VNYDGQ-QAYDVADM 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  318 LKTFLRELPEPLLTFDLYPhvvGFLNI----DESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLA 393
Cdd:cd04375  79 LKQYFRDLPEPLLTNKLSE---TFIAIfqyvPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTATNLA 155


                ....*..
gi 4757766  394 VVFGPNL 400
Cdd:cd04375 156 VCLAPSL 162
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-424 1.24e-21

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 92.19  E-value: 1.24e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQHLQEKNPEQepIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNM-GLPVDFDQ--YNELHLPAVIL 318
Cdd:cd04372   1 YGCDLTTLVKAHNTQ--RPMVVDMCIREIEARGLQSEGLYRVSGFAEEIEDVKMAFDRdGEKADISAtvYPDINVITGAL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  319 KTFLRELPEPLLTFDLYPHVVGFLNI-DESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFG 397
Cdd:cd04372  79 KLYFRDLPIPVITYDTYPKFIDAAKIsNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFG 158

                       170       180
                ....*....|....*....|....*..
gi 4757766  398 PNLLWAKDAAiTLKAINPInTFTKFLL 424
Cdd:cd04372 159 PTLMRPPEDS-ALTTLNDM-RYQILIV 183
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-413 1.94e-21

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 91.79  E-value: 1.94e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQHLQEKNPEQepIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLP-VDFDQYNElHLPAVILKT 320
Cdd:cd04409   1 FGADFAQVAKKSPDG--IPFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFENGKDlVELSELSP-HDISNVLKL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  321 FLRELPEPLLTFDLYPHVVGF----LNIDESQRVPATLQ-------------------VLQTLPEENYQVLRFLTAFLVQ 377
Cdd:cd04409  78 YLRQLPEPLILFRLYNEFIGLakesQHVNETQEAKKNSDkkwpnmctelnrillkskdLLRQLPAPNYNTLQFLIVHLHR 157

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 4757766  378 ISAHSDQNKMTNTNLAVVFGPNLLWAK--DAAITLKAI 413
Cdd:cd04409 158 VSEQAEENKMSASNLGIIFGPTLIRPRptDATVSLSSL 195
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-435 3.34e-21

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 91.27  E-value: 3.34e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQHLQEKN---------PEQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMG--LPVDFDQYNE 310
Cdd:cd04397   1 FGVPLEILVEKFgadstlgvgPGKLRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNptEVPDLSKENP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  311 LHLpAVILKTFLRELPEPLLTFDLYPHVVGFLNI-DESQRVPATLQVLQTLPEENYQVLRFLTAFLVQIS--AHSDQ--- 384
Cdd:cd04397  81 VQL-AALLKKFLRELPDPLLTFKLYRLWISSQKIeDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSsfSHIDEetg 159

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 4757766  385 NKMTNTNLAVVFGPNLLWAKDAAITLK-----AINPINTftkfLLDHQGELFPSPD 435
Cdd:cd04397 160 SKMDIHNLATVITPNILYSKTDNPNTGdeyflAIEAVNY----LIENNEEFCEVPD 211
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 263-408 3.71e-20

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 88.22  E-value: 3.71e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  263 LRETVAYLQAHALTTEGIFRrsaNTQVVREVQQKYNMGL------PVDFDQYN---ELHLPAVILKTFLRELPEPLLTFD 333
Cdd:cd04374  32 VRKCIEAVETRGINEQGLYR---VVGVNSKVQKLLSLGLdpktstPGDVDLDNsewEIKTITSALKTYLRNLPEPLMTYE 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  334 LYPhvvGFLNI----DESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLWAKD---A 406
Cdd:cd04374 109 LHN---DFINAakseNLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGPTLLRPQEetvA 185


                ..
gi 4757766  407 AI 408
Cdd:cd04374 186 AI 187
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 257-401 4.11e-20

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 87.48  E-value: 4.11e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  257 EPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGL-PVDFDQYN-ELHLPAVILKTFLRELPEPLLTFDL 334
Cdd:cd04383  16 QAIPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFERGEdPLADDQNDhDINSVAGVLKLYFRGLENPLFPKER 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4757766  335 YPHVVGFLNIDESQ-RVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLL 401
Cdd:cd04383  96 FEDLMSCVKLENPTeRVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAICFGPTLM 163
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 241-404 6.82e-20

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 87.17  E-value: 6.82e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  241 QFGVSLQHLQEKNPEQepIPIVLRETVAYLQAHALTTeGIFRRSANTQVVREVQQKYNMGLPVDFDQYN---ELHLPAVI 317
Cdd:cd04384   2 VFGCDLTEHLLNSGQD--VPQVLKSCTEFIEKHGIVD-GIYRLSGIASNIQRLRHEFDSEQIPDLTKDVyiqDIHSVSSL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  318 LKTFLRELPEPLLTFDLYPHVVGFLNIDE-SQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVF 396
Cdd:cd04384  79 CKLYFRELPNPLLTYQLYEKFSEAVSAASdEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAIVW 158


                ....*...
gi 4757766  397 GPNLLWAK 404
Cdd:cd04384 159 APNLLRSK 166
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 242-434 3.44e-19

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 85.86  E-value: 3.44e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQHLQEKNPEQEP---IPIVLRETVAYLQAHALTTEGIFRRSANTQVV----REVQQKYNMGlPVDFDQYNElHLP 314
Cdd:cd04391   2 FGVPLSTLLERDQKKVPgskVPLIFQKLINKLEERGLETEGILRIPGSAQRVkflcQELEAKFYEG-TFLWDQVKQ-HDA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  315 AVILKTFLRELPEPLLTFDLYPhvvGFLNIDESQRVPATLQVLQ----TLPEENYQVLRFLTAFLVQISAHSDQNKMTNT 390
Cdd:cd04391  80 ASLLKLFIRELPQPLLTVEYLP---AFYSVQGLPSKKDQLQALNllvlLLPEANRDTLKALLEFLQKVVDHEEKNKMNLW 156

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 4757766  391 NLAVVFGPNL-----LWAKDAAITLKAINPINT---FTKFLLDHQGELFPSP 434
Cdd:cd04391 157 NVAMIMAPNLfpprgKHSKDNESLQEEVNMAAGcanIMRLLIRYQDLLWTVP 208
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 242-401 3.71e-19

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 85.25  E-value: 3.71e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQHLQEKNPEQEPIpIVLRETvAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLP-VDFDQyNELHLPAVILKT 320
Cdd:cd04408   1 FGVDFSQLPRDFPEEVPF-VVVRCT-AEIENRALGVQGIYRISGSKARVEKLCQAFENGRDlVDLSG-HSPHDITSVLKH 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  321 FLRELPEPLLTFDLYPHVVGF---------LNIDESQRVPATLQVLQTL----PEENYQVLRFLTAFLVQISAHSDQNKM 387
Cdd:cd04408  78 FLKELPEPVLPFQLYDDFIALakelqrdseKAAESPSIVENIIRSLKELlgrlPVSNYNTLRHLMAHLYRVAERFEDNKM 157

                       170
                ....*....|....
gi 4757766  388 TNTNLAVVFGPNLL 401
Cdd:cd04408 158 SPNNLGIVFGPTLL 171
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 267-434 3.04e-18

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 82.89  E-value: 3.04e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  267 VAYLQAHaLTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYN-ELHLPAVILKTFLRELPEPLLTFDLYP------HVV 339
Cdd:cd04392  17 IEYLEKN-LRVEGLFRKPGNSARQQELRDLLNSGTDLDLESGGfHAHDCATVLKGFLGELPEPLLTHAHYPahlqiaDLC 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  340 GFLN------IDESQRVPATLQVL-QTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLLW-----AKDAA 407
Cdd:cd04392  96 QFDEkgnktsAPDKERLLEALQLLlLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTPHLICprnltPEDLH 175

                       170       180
                ....*....|....*....|....*..
gi 4757766  408 ITLKAINPINTftkFLLDHQGELFPSP 434
Cdd:cd04392 176 ENAQKLNSIVT---FMIKHSQKLFKAP 199
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 242-400 3.81e-18

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 81.71  E-value: 3.81e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQHLQEKNPEQEPI--PIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYnELHLPAVILK 319
Cdd:cd04381   1 FGASLSLAVERSRCHDGIdlPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLEEY-EPPTVASLLK 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  320 TFLRELPEPLLTFDLYP---HVVGFLNidESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVF 396
Cdd:cd04381  80 QYLRELPEPLLTKELMPrfeEACGRPT--EAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISIVL 157


                ....
gi 4757766  397 GPNL 400
Cdd:cd04381 158 SPTV 161
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 255-401 8.09e-17

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 78.43  E-value: 8.09e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  255 EQEPIPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAV--ILKTFLRELPEPLLTF 332
Cdd:cd04387  12 ERSKVPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFDTNNKDVSVMLSEMDVNAIagTLKLYFRELPEPLFTD 91

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  333 DLYPHVVGFLNI-DESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAVVFGPNLL 401
Cdd:cd04387  92 ELYPNFAEGIALsDPVAKESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLATVFGPTLL 161
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 242-426 8.64e-17

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 78.20  E-value: 8.64e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQHL----QEKNPEQEpIPIV---LRETVAYLQAHalTTEGIFRRSANTQVVREVQQKYNMGLpVDFDQYNELHLP 314
Cdd:cd04389   1 FGSSLEEImdrqKEKYPELK-LPWIltfLSEKVLALGGF--QTEGIFRVPGDIDEVNELKLRVDQWD-YPLSGLEDPHVP 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  315 AVILKTFLRELPEPLLTFDLYPHVvgflnIDESQRVPATLQVLQTLPEENYQVLRFLTAFLVQ--ISAHSDQNKMTNTNL 392
Cdd:cd04389  77 ASLLKLWLRELEEPLIPDALYQQC-----ISASEDPDKAVEIVQKLPIINRLVLCYLINFLQVfaQPENVAHTKMDVSNL 151

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 4757766  393 AVVFGPNLL--WAKDAAITLKAINPINTFTKFLLDH 426
Cdd:cd04389 152 AMVFAPNILrcTSDDPRVIFENTRKEMSFLRTLIEH 187
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 248-400 2.04e-13

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 68.47  E-value: 2.04e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  248 HLQEKNPEQEP-IPIVLRETVAYLQAHALTTEGIFRRSANTQVVREVQQKYNMGLPV----DFDqyneLHLPAVILKTFL 322
Cdd:cd04382   5 ELADFDPSTSPmIPALIVHCVNEIEARGLTEEGLYRVSGSEREVKALKEKFLRGKTVpnlsKVD----IHVICGCLKDFL 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4757766  323 RELPEPLLTFDLYPH-VVGFLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFLvQISAHSDQNKMTNTNLAVVFGPNL 400
Cdd:cd04382  81 RSLKEPLITFALWKEfMEAAEILDEDNSRAALYQAISELPQPNRDTLAFLILHL-QRVAQSPECKMDINNLARVFGPTI 158
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 242-419 2.12e-11

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 63.13  E-value: 2.12e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  242 FGVSLQHLQEKNPEQEP--IPIVLRETVAYLQAHALTTEGIFR----RSANTQVVREVQQKYNMGLPvdFDQYNELHLPA 315
Cdd:cd04380  31 LIDQLELGDNPDYSEVPlsIPKEIWRLVDYLYTRGLAQEGLFEepglPSEPGELLAEIRDALDTGSP--FNSPGSAESVA 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766  316 VILKTFLRELPEPLLTFDLYPHVVGFLNIDESQRvpatLQVL-QTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNLAV 394
Cdd:cd04380 109 EALLLFLESLPDPIIPYSLYERLLEAVANNEEDK----RQVIrISLPPVHRNVFVYLCSFLRELLSESADRGLDENTLAT 184

                       170       180       190
                ....*....|....*....|....*....|..
gi 4757766  395 VFGPNLL-------WAKDAAITLKAINPINTF 419
Cdd:cd04380 185 IFGRVLLrdppragGKERRAERDRKRAFIEQF 216
CRAL_TRIO pfam00650
CRAL/TRIO domain;
77-204 5.96e-04

CRAL/TRIO domain;


Pssm-ID: 459890 [Multi-domain]  Cd Length: 151  Bit Score: 40.32  E-value: 5.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757766     77 GDDKYGRKIIVFSACRMPPsHQLDHSKLLGYLKHTLDQ--------YVESdYTLLYLHHGLTSDNKPS---------LSW 139
Cdd:pfam00650   8 GRDKEGRPVLYLRLGRHDP-KKSSEEELVRFLVLVLERalllmpegQVEG-LTVIIDLKGLSLSNMDWwsisllkkiIKI 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4757766    140 LRDAYREfdrkykkNIKALYIVHPTMFIKTLLILFKPLISFKFGQKIFYVN--YLSELSEHVKLEQL 204
Cdd:pfam00650  86 LQDNYPE-------RLGKILIVNAPWIFNTIWKLIKPFLDPKTREKIVFLKnsNEEELEKYIPPEQL 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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