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Conserved domains on  [gi|72256200|ref|NP_004317|]
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B-cell CLL/lymphoma 9 protein [Homo sapiens]

Protein Classification

BCL9 and PHA03247 domain-containing protein( domain architecture ID 10568824)

BCL9 and PHA03247 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 571-1186 2.44e-16

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 85.38  E-value: 2.44e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   571 SEMEGPNVPNPASRPGLSGVSWPDDVPkiPDGRNFPpgqGIFSGPGRGERFPnPQGLSEEMFQQQLAEKQLGLPPGMAME 650
Cdd:PHA03247 2484 AEARFPFAAGAAPDPGGGGPPDPDAPP--APSRLAP---AILPDEPVGEPVH-PRMLTWIRGLEELASDDAGDPPPPLPP 2557

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   651 GIRPSMEmNRMIPGSQ---RHMEPG-----------NNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGm 716
Cdd:PHA03247 2558 AAPPAAP-DRSVPPPRpapRPSEPAvtsrarrpdapPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAA- 2635

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   717 kgdvNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRpggsdmlpAQQKMVPLPFGEHPQqeygmGPRPflpmsqgpgsnsg 796
Cdd:PHA03247 2636 ----NEPDPHPPPTVPPPERPRDDPAPGRVSRPRR--------ARRLGRAAQASSPPQ-----RPRR------------- 2685

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   797 lRNLREPIGPdqrtNSRLSHMPPLPLNPSSNPTSLNTAPPVqrglgrkPLDISVAGSQVHSPGINPLKSPTMHQVQSPML 876
Cdd:PHA03247 2686 -RAARPTVGS----LTSLADPPPPPPTPEPAPHALVSATPL-------PPGPAAARQASPALPAAPAPPAVPAGPATPGG 2753

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   877 GSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTM 956
Cdd:PHA03247 2754 PARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   957 ASPAmlGNVESGGPPPPTASQPASVnIPGSLPSSTPYTMPPePTLSQNPLSIMMSRMSKFAMPSSTplyhdaiKTVASSD 1036
Cdd:PHA03247 2834 AQPT--APPPPPGPPPPSLPLGGSV-APGGDVRRRPPSRSP-AAKPAAPARPPVRRLARPAVSRST-------ESFALPP 2902

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200  1037 DDSPPARSPNLPsmnnmpgmgintQNPRISGPNPVVPMPTLSPmgMTQPLSHSNQMPSPNAVGPNIPPHGVPmgpglmsh 1116
Cdd:PHA03247 2903 DQPERPPQPQAP------------PPPQPQPQPPPPPQPQPPP--PPPPRPQPPLAPTTDPAGAGEPSGAVP-------- 2960

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200  1117 NPIMGHGSqePPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFpGEGPLGRPSNLPQS 1186
Cdd:PHA03247 2961 QPWLGALV--PGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLAL-HEETDPPPVSLKQT 3027
BCL9 pfam11502
B-cell lymphoma 9 protein; The Wnt pathway plays a role in embryonic development, stem cell ...
 350-386 6.09e-10

B-cell lymphoma 9 protein; The Wnt pathway plays a role in embryonic development, stem cell growth and tumorigenesis. BCL9 associates with beta-catenin and Tcf in the nucleus when the Wnt pathway is stimulated leading to the transactivation of Wnt target genes.


:

Pssm-ID: 431912 [Multi-domain]  Cd Length: 37  Bit Score: 55.48  E-value: 6.09e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 72256200    350 GLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSG 386
Cdd:pfam11502    1 NLTPQQRQHRERQLATLRKMQRMLFPENQAGVGGDPS 37
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 571-1186 2.44e-16

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 85.38  E-value: 2.44e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   571 SEMEGPNVPNPASRPGLSGVSWPDDVPkiPDGRNFPpgqGIFSGPGRGERFPnPQGLSEEMFQQQLAEKQLGLPPGMAME 650
Cdd:PHA03247 2484 AEARFPFAAGAAPDPGGGGPPDPDAPP--APSRLAP---AILPDEPVGEPVH-PRMLTWIRGLEELASDDAGDPPPPLPP 2557

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   651 GIRPSMEmNRMIPGSQ---RHMEPG-----------NNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGm 716
Cdd:PHA03247 2558 AAPPAAP-DRSVPPPRpapRPSEPAvtsrarrpdapPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAA- 2635

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   717 kgdvNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRpggsdmlpAQQKMVPLPFGEHPQqeygmGPRPflpmsqgpgsnsg 796
Cdd:PHA03247 2636 ----NEPDPHPPPTVPPPERPRDDPAPGRVSRPRR--------ARRLGRAAQASSPPQ-----RPRR------------- 2685

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   797 lRNLREPIGPdqrtNSRLSHMPPLPLNPSSNPTSLNTAPPVqrglgrkPLDISVAGSQVHSPGINPLKSPTMHQVQSPML 876
Cdd:PHA03247 2686 -RAARPTVGS----LTSLADPPPPPPTPEPAPHALVSATPL-------PPGPAAARQASPALPAAPAPPAVPAGPATPGG 2753

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   877 GSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTM 956
Cdd:PHA03247 2754 PARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   957 ASPAmlGNVESGGPPPPTASQPASVnIPGSLPSSTPYTMPPePTLSQNPLSIMMSRMSKFAMPSSTplyhdaiKTVASSD 1036
Cdd:PHA03247 2834 AQPT--APPPPPGPPPPSLPLGGSV-APGGDVRRRPPSRSP-AAKPAAPARPPVRRLARPAVSRST-------ESFALPP 2902

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200  1037 DDSPPARSPNLPsmnnmpgmgintQNPRISGPNPVVPMPTLSPmgMTQPLSHSNQMPSPNAVGPNIPPHGVPmgpglmsh 1116
Cdd:PHA03247 2903 DQPERPPQPQAP------------PPPQPQPQPPPPPQPQPPP--PPPPRPQPPLAPTTDPAGAGEPSGAVP-------- 2960

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200  1117 NPIMGHGSqePPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFpGEGPLGRPSNLPQS 1186
Cdd:PHA03247 2961 QPWLGALV--PGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLAL-HEETDPPPVSLKQT 3027
BCL9 pfam11502
B-cell lymphoma 9 protein; The Wnt pathway plays a role in embryonic development, stem cell ...
 350-386 6.09e-10

B-cell lymphoma 9 protein; The Wnt pathway plays a role in embryonic development, stem cell growth and tumorigenesis. BCL9 associates with beta-catenin and Tcf in the nucleus when the Wnt pathway is stimulated leading to the transactivation of Wnt target genes.


Pssm-ID: 431912 [Multi-domain]  Cd Length: 37  Bit Score: 55.48  E-value: 6.09e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 72256200    350 GLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSG 386
Cdd:pfam11502    1 NLTPQQRQHRERQLATLRKMQRMLFPENQAGVGGDPS 37
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 868-1192 4.45e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 48.22  E-value: 4.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200    868 MHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASP------------------VHLKSPSLPAP 929
Cdd:pfam03154  166 ILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQppnqtqstaaphtliqqtPTLHPQRLPSP 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200    930 SPGWTSSPKPPlqspgiPPNHKAPLTMASPAMLGNvesgGPPPPTASQPASVNIPGSLPSStPYTMPPEPTLSQNPLSIM 1009
Cdd:pfam03154  246 HPPLQPMTQPP------PPSQVSPQPLPQPSLHGQ----MPPMPHSLQTGPSHMQHPVPPQ-PFPLTPQSSQSQVPPGPS 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   1010 MSRMSKFAMPSSTPlyhdaiKTVASSDDDSPPARSPNLPSMNNMPGMgintqNPRISGPNPVVPMPTL----SPMGMTQP 1085
Cdd:pfam03154  315 PAAPGQSQQRIHTP------PSQSQLQSQQPPREQPLPPAPLSMPHI-----KPPPTTPIPQLPNPQShkhpPHLSGPSP 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   1086 LSHSNQMPSPNAVGP------NIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGrmgfpQGFPPVQSPPQQVPFPHNGPS 1159
Cdd:pfam03154  384 FQMNSNLPPPPALKPlsslstHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQS-----QSLPPPAASHPPTSGLHQVPS 458

                          330       340       350
                   ....*....|....*....|....*....|...
gi 72256200   1160 ggQGSFPGGMGFPGEGPLGRPSNLPQSSADAAL 1192
Cdd:pfam03154  459 --QSPFPQHPFVPGGPPPITPPSGPPTSTSSAM 489
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 571-1186 2.44e-16

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 85.38  E-value: 2.44e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   571 SEMEGPNVPNPASRPGLSGVSWPDDVPkiPDGRNFPpgqGIFSGPGRGERFPnPQGLSEEMFQQQLAEKQLGLPPGMAME 650
Cdd:PHA03247 2484 AEARFPFAAGAAPDPGGGGPPDPDAPP--APSRLAP---AILPDEPVGEPVH-PRMLTWIRGLEELASDDAGDPPPPLPP 2557

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   651 GIRPSMEmNRMIPGSQ---RHMEPG-----------NNPIFPRIPVEGPLSPSRGDFPKGIPPQMGPGRELEFGMVPSGm 716
Cdd:PHA03247 2558 AAPPAAP-DRSVPPPRpapRPSEPAvtsrarrpdapPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAA- 2635

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   717 kgdvNLNVNMGSNSQMIPQKMREAGAGPEEMLKLRpggsdmlpAQQKMVPLPFGEHPQqeygmGPRPflpmsqgpgsnsg 796
Cdd:PHA03247 2636 ----NEPDPHPPPTVPPPERPRDDPAPGRVSRPRR--------ARRLGRAAQASSPPQ-----RPRR------------- 2685

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   797 lRNLREPIGPdqrtNSRLSHMPPLPLNPSSNPTSLNTAPPVqrglgrkPLDISVAGSQVHSPGINPLKSPTMHQVQSPML 876
Cdd:PHA03247 2686 -RAARPTVGS----LTSLADPPPPPPTPEPAPHALVSATPL-------PPGPAAARQASPALPAAPAPPAVPAGPATPGG 2753

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   877 GSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTM 956
Cdd:PHA03247 2754 PARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   957 ASPAmlGNVESGGPPPPTASQPASVnIPGSLPSSTPYTMPPePTLSQNPLSIMMSRMSKFAMPSSTplyhdaiKTVASSD 1036
Cdd:PHA03247 2834 AQPT--APPPPPGPPPPSLPLGGSV-APGGDVRRRPPSRSP-AAKPAAPARPPVRRLARPAVSRST-------ESFALPP 2902

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200  1037 DDSPPARSPNLPsmnnmpgmgintQNPRISGPNPVVPMPTLSPmgMTQPLSHSNQMPSPNAVGPNIPPHGVPmgpglmsh 1116
Cdd:PHA03247 2903 DQPERPPQPQAP------------PPPQPQPQPPPPPQPQPPP--PPPPRPQPPLAPTTDPAGAGEPSGAVP-------- 2960

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200  1117 NPIMGHGSqePPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFpGEGPLGRPSNLPQS 1186
Cdd:PHA03247 2961 QPWLGALV--PGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLAL-HEETDPPPVSLKQT 3027
BCL9 pfam11502
B-cell lymphoma 9 protein; The Wnt pathway plays a role in embryonic development, stem cell ...
 350-386 6.09e-10

B-cell lymphoma 9 protein; The Wnt pathway plays a role in embryonic development, stem cell growth and tumorigenesis. BCL9 associates with beta-catenin and Tcf in the nucleus when the Wnt pathway is stimulated leading to the transactivation of Wnt target genes.


Pssm-ID: 431912 [Multi-domain]  Cd Length: 37  Bit Score: 55.48  E-value: 6.09e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 72256200    350 GLSQEQLEHRERSLQTLRDIQRMLFPDEKEFTGAQSG 386
Cdd:pfam11502    1 NLTPQQRQHRERQLATLRKMQRMLFPENQAGVGGDPS 37
PHA03247 PHA03247
large tegument protein UL36; Provisional
 908-1336 8.01e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.72  E-value: 8.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   908 PPVLGSAAASPVHLKS--PSLPAPSPgwtssPKPPLQS----PGIPPNHKAPLTMASPAMlgnvESGGPPPPTASQPASV 981
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRSvpPPRPAPRP-----SEPAVTSrarrPDAPPQSARPRAPVDDRG----DPRGPAPPSPLPPDTH 2622

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   982 niPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARsPNLPSMNNMPGMGINTQ 1061
Cdd:PHA03247 2623 --APDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQR-PRRRAARPTVGSLTSLA 2699

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200  1062 NPRISGPNPVVPMPTLSPMGMTQPLSHSNQMPSPNAVGPNIPPhGVPMGPGLmshnpimgHGSQEPPMVPQGRMGFPQGF 1141
Cdd:PHA03247 2700 DPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPP-AVPAGPAT--------PGGPARPARPPTTAGPPAPA 2770

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200  1142 PP---VQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLgrpsnlPQSSADAALCKPGGPGGPDSFTVLGNSMPSVFTDP 1218
Cdd:PHA03247 2771 PPaapAAGPPRRLTRPAVASLSESRESLPSPWDPADPPA------AVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG 2844

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200  1219 DLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGPGPVG 1298
Cdd:PHA03247 2845 PPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPP 2924

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 72256200  1299 TPDIPLGTAPSMPGHNPMRPPAFLQQGMMGPHHRMMSP 1336
Cdd:PHA03247 2925 PPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962
PHA03247 PHA03247
large tegument protein UL36; Provisional
 918-1410 7.30e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 7.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   918 PVHLKSPSLPAPSPGWTSSPKPPLQSPGiPPNHKAPLTMAS--------PAM---------LGNVESGGPPPPTASQPAS 980
Cdd:PHA03247 2483 PAEARFPFAAGAAPDPGGGGPPDPDAPP-APSRLAPAILPDepvgepvhPRMltwirgleeLASDDAGDPPPPLPPAAPP 2561

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   981 VNIPGSLPSSTPYTMPPEPTLSqnplsimmsrmSKFAMPSSTPlyHDAIKTVASSDDDSPPARSPNLPSmnnmpgmgint 1060
Cdd:PHA03247 2562 AAPDRSVPPPRPAPRPSEPAVT-----------SRARRPDAPP--QSARPRAPVDDRGDPRGPAPPSPL----------- 2617

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200  1061 qNPRISGPNPvvPMPTLSPMGMTQPLSHSNQMPSPNAvgpnipPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGRMGFPQG 1140
Cdd:PHA03247 2618 -PPDTHAPDP--PPPSPSPAANEPDPHPPPTVPPPER------PRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAA 2688

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200  1141 FPPVQS------PPQQVPFPHNGPSGGQGSFPggmgFPGEGPLGRPSNLPQSSADAALCKPGGPGGPDSFTVLGNsmPSV 1214
Cdd:PHA03247 2689 RPTVGSltsladPPPPPPTPEPAPHALVSATP----LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPAR--PPT 2762

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200  1215 FTDPDLQEVIRPGATGIPEFDLSRIIPSEKPSQTLQYFPRGEVPGRKQPQGPGPGFSHMQGMMGEQAPRMGLALPGMGGP 1294
Cdd:PHA03247 2763 TAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPP 2842

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200  1295 GPVGTPDIPLGTAPSMPGHNPMRPPAflQQGMMGPHHRMMSPAQSTMPGQPTLMSNPAAAVGMIPGKDRGPAglyTHPGP 1374
Cdd:PHA03247 2843 PGPPPPSLPLGGSVAPGGDVRRRPPS--RSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQ---APPPP 2917

                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 72256200  1375 VGSPGMMMSMQGMMGPQQNIMIPPQMRPRGMAADVG 1410
Cdd:PHA03247 2918 QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAG 2953
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 868-1192 4.45e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 48.22  E-value: 4.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200    868 MHQVQSPMLGSPSGNLKSPQTPSQLAGMLAGPAAAASIKSPPVLGSAAASP------------------VHLKSPSLPAP 929
Cdd:pfam03154  166 ILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQppnqtqstaaphtliqqtPTLHPQRLPSP 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200    930 SPGWTSSPKPPlqspgiPPNHKAPLTMASPAMLGNvesgGPPPPTASQPASVNIPGSLPSStPYTMPPEPTLSQNPLSIM 1009
Cdd:pfam03154  246 HPPLQPMTQPP------PPSQVSPQPLPQPSLHGQ----MPPMPHSLQTGPSHMQHPVPPQ-PFPLTPQSSQSQVPPGPS 314

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   1010 MSRMSKFAMPSSTPlyhdaiKTVASSDDDSPPARSPNLPSMNNMPGMgintqNPRISGPNPVVPMPTL----SPMGMTQP 1085
Cdd:pfam03154  315 PAAPGQSQQRIHTP------PSQSQLQSQQPPREQPLPPAPLSMPHI-----KPPPTTPIPQLPNPQShkhpPHLSGPSP 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   1086 LSHSNQMPSPNAVGP------NIPPHGVPMGPGLMSHNPIMGHGSQEPPMVPQGrmgfpQGFPPVQSPPQQVPFPHNGPS 1159
Cdd:pfam03154  384 FQMNSNLPPPPALKPlsslstHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQS-----QSLPPPAASHPPTSGLHQVPS 458

                          330       340       350
                   ....*....|....*....|....*....|...
gi 72256200   1160 ggQGSFPGGMGFPGEGPLGRPSNLPQSSADAAL 1192
Cdd:pfam03154  459 --QSPFPQHPFVPGGPPPITPPSGPPTSTSSAM 489
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
889-1125 9.46e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 9.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   889 PSQLAGMlAGPAAAASI----KSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAmlgN 964
Cdd:PRK12323  365 PGQSGGG-AGPATAAAApvaqPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQA---S 440

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   965 VESGGPPPPTASQPASVNIPGSLPSSTPytMPPEPTLSQNPLSIMMSRMSKFAMPSSTPLYHDAIKTVAS-SDDDSPPAR 1043
Cdd:PRK12323  441 ARGPGGAPAPAPAPAAAPAAAARPAAAG--PRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASpAPAQPDAAP 518

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200  1044 SPNLPSMNNMPGmginTQNPRISGPNPVVPmPTLSPMGMTQPLSHSNQMPSPNAVG-PNIPPHGVPMGPGLMSHNPIMGH 1122
Cdd:PRK12323  519 AGWVAESIPDPA----TADPDDAFETLAPA-PAAAPAPRAAAATEPVVAPRPPRASaSGLPDMFDGDWPALAARLPVRGL 593


                  ...
gi 72256200  1123 GSQ 1125
Cdd:PRK12323  594 AQQ 596
PHA03247 PHA03247
large tegument protein UL36; Provisional
 506-1038 1.99e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   506 GPRGVVRGPPPPYQMTPSEGWAPGGTEPFSDGINMPHSLPPRGMAPHPNMPGsqmrlpgfagminsemegpnvpnPASRP 585
Cdd:PHA03247 2579 EPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPS-----------------------PSPAA 2635

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   586 GLSGVSWPDDVPKIPDGRNFPPGqGIFSGPGRGERFPNPQGLSEEMfqQQLAEKQLGLPPGMAMEGIRPsmemnrmiPGS 665
Cdd:PHA03247 2636 NEPDPHPPPTVPPPERPRDDPAP-GRVSRPRRARRLGRAAQASSPP--QRPRRRAARPTVGSLTSLADP--------PPP 2704

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   666 QRHMEPGNNPIFPRIPVEGPLSPSRGDFPkGIPPQMGPGRELEFGMVPSGMKGDVNLNVNMGSNSQMIPqkmREAGAGPE 745
Cdd:PHA03247 2705 PPTPEPAPHALVSATPLPPGPAAARQASP-ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP---AAPAAGPP 2780

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   746 EMLKLRPGGSdmLPAQQKMVPLPFGEHPQQEYGMGPRPFLPMSQGPGsnsglrnlrepigpdqrtnsrlshmPPLPLNPS 825
Cdd:PHA03247 2781 RRLTRPAVAS--LSESRESLPSPWDPADPPAAVLAPAAALPPAASPA-------------------------GPLPPPTS 2833

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   826 SNPTSLNTAPPvqrglgrkPLDISVAGSQVHSPGINPLKSPTMhqvqspmlGSPSGNLKSPQTPSqlAGMLAGPAAAASI 905
Cdd:PHA03247 2834 AQPTAPPPPPG--------PPPPSLPLGGSVAPGGDVRRRPPS--------RSPAAKPAAPARPP--VRRLARPAVSRST 2895

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   906 KS--PPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAmlgNVESGGPPPPT--ASQPASV 981
Cdd:PHA03247 2896 ESfaLPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGA---GEPSGAVPQPWlgALVPGRV 2972

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 72256200   982 NIPGSLPS----STPYTMPPEPTLSQNPLSIMMSRMSKFAM-PSSTPLYHDAIKTVASSDDD 1038
Cdd:PHA03247 2973 AVPRFRVPqpapSREAPASSTPPLTGHSLSRVSSWASSLALhEETDPPPVSLKQTLWPPDDT 3034
ARS2 pfam04959
Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a ...
 1114-1182 2.06e-03

Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a co-mutagen by inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance.


Pssm-ID: 461498  Cd Length: 195  Bit Score: 41.02  E-value: 2.06e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 72256200   1114 MSHNPIMGHGSQEPPMVPQGRMGFPQGFPPVQSPPQQVPFPHNGPSGGQGSFPGGMGFPGEGPLGRPSN 1182
Cdd:pfam04959  127 RPANRRERPGRAFPSQRPQGQMSDGHPRPPMDGPGGGPPFPPNQYGGGRGNYDNFRGQGGGGYPPKPRD 195
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 922-1102 3.14e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.21  E-value: 3.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200    922 KSPSLPAPSPGW-TSSPKPPLQSPGIPPNHKAPLTMASPAMLGnvesggpPPPTASQPASVNIPGSLPSSTPYTMPPEP- 999
Cdd:pfam05109  423 KAPESTTTSPTLnTTGFAAPNTTTGLPSSTHVPTNLTAPASTG-------PTVSTADVTSPTPAGTTSGASPVTPSPSPr 495

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   1000 ---TLSQNPlsIMMSRMSKFAMPSSTPLYHDAIKTVASSDDDSPPARSPNLPSMNNMPGMGINTQNPRISGPNPVVPMPT 1076
Cdd:pfam05109  496 dngTESKAP--DMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPT 573

                          170       180
                   ....*....|....*....|....*.
gi 72256200   1077 LspmGMTQPLShSNQMPSPNAVGPNI 1102
Cdd:pfam05109  574 L---GKTSPTS-AVTTPTPNATSPTV 595
KAR9 pfam08580
Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal ...
 846-1094 3.16e-03

Yeast cortical protein KAR9; The KAR9 protein in Saccharomyces cerevisiae is a cytoskeletal protein required for karyogamy, correct positioning of the mitotic spindle and for orientation of cytoplasmic microtubules. KAR9 localizes at the shmoo tip in mating cells and at the tip of the growing bud in anaphase.


Pssm-ID: 430088 [Multi-domain]  Cd Length: 684  Bit Score: 42.12  E-value: 3.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200    846 LDISVAGSQVHSPGINPLKSPTMHQVQSpmlGSPSGNLKSPQTPSqlAGMLAGPAAAASIKSPPVLGSAAA-SPVHLKSP 924
Cdd:pfam08580  418 EDSPATLVANKTPGSSPPSSVIMTPVNK---GSKTPSSRRGSSFD--FGSSSERVINSKLRRESKLPQIAStLKQTKRPS 492

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200    925 SLPAPSPgwtssPKPPLQSPgiPPNhkaPLTMASPAMLGNVESGGPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQN 1004
Cdd:pfam08580  493 KIPRASP-----NHSGFLST--PSN---TATSETPTPALRPPSRPQPPPPGNRPRWNASTNTNDLDVGHNFKPLTLTTPS 562

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   1005 PLSIMMSRmSKFAMPSSTPLYHDAiktvasSDDDSPPARSPNLPSmnnmpgMGINTQNP-RISGPNPvvPMPTLSPMGMT 1083
Cdd:pfam08580  563 PTPSRSSR-SSSTLPPVSPLSRDK------SRSPAPTCRSVSRAS------RRRASRKPtRIGSPNS--RTSLLDEPPYP 627

                          250
                   ....*....|.
gi 72256200   1084 QpLSHSNQMPS 1094
Cdd:pfam08580  628 K-LTLSKGLPR 637
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 878-1002 5.25e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 41.20  E-value: 5.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   878 SPSGNLKSPQTPSQLAGMLAGpaAAASIKSPPVLGSAAASPVHLKSPSLPAP---SPGWTSSPKPPL-QSPGIPPnhkap 953
Cdd:PRK14959  372 RPSGGGASAPSGSAAEGPASG--GAATIPTPGTQGPQGTAPAAGMTPSSAAPatpAPSAAPSPRVPWdDAPPAPP----- 444

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 72256200   954 ltmaspamlgnvESGGPPPPTASQPASVNIPGSlPSSTPYTMPPEPTLS 1002
Cdd:PRK14959  445 ------------RSGIPPRPAPRMPEASPVPGA-PDSVASASDAPPTLG 480
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 893-1005 6.55e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 40.85  E-value: 6.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   893 AGMLAGPAAAASIKSPPVLGSAAASPVhlkspslPAPSPGWTSSPKPPLQSPGIPpnhkAPLTMASPAMLGNVESGGPPP 972
Cdd:PRK14951  368 AAAEAAAPAEKKTPARPEAAAPAAAPV-------AQAAAAPAPAAAPAAAASAPA----APPAAAPPAPVAAPAAAAPAA 436

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 72256200   973 PTASQPASVNIPGSLPS-------STPYTMPPEPTLSQNP 1005
Cdd:PRK14951  437 APAAAPAAVALAPAPPAqaapetvAIPVRVAPEPAVASAA 476
PHA03247 PHA03247
large tegument protein UL36; Provisional
 865-999 7.53e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 7.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   865 SPTMHQVQSPMLGSPSGNLKSPQTPSQLAGMLAG--------PAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSS 936
Cdd:PHA03247  338 SPLPRPRQHYPLGFPKRRRPTWTPPSSLEDLSAGrhhpkrasLPTRKRRSARHAATPFARGPGGDDQTRPAAPVPASVPT 417

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 72256200   937 PKPPLQSPGIPPNHKAPLTMASPAmlgnvESGGPPPPTASQPASVNIPGSLPSSTPYT----------MPPEP 999
Cdd:PHA03247  418 PAPTPVPASAPPPPATPLPSAEPG-----SDDGPAPPPERQPPAPATEPAPDDPDDATrkaldalrerRPPEP 485
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
886-1080 8.48e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 8.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   886 PQTPSQLAGMLAGPAAAASIKSPPVLGSAAASPVHLKSPSLPAPSPGWTSSPKPPLQSPGIPPNHKAPLTMASPAmlgnv 965
Cdd:PRK12323  396 APAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPR----- 470

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72256200   966 esggPPPPTASQPASVNIPGSLPSSTPYTMPPEPTLSQNPLSIMMSRMSkfamPSSTPLYHDAIKTVASSDDDSPPARSP 1045
Cdd:PRK12323  471 ----PVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPD----AAPAGWVAESIPDPATADPDDAFETLA 542

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 72256200  1046 NLPSMNNMPGMGINTQnPRISGPNPVVPMPTLSPM 1080
Cdd:PRK12323  543 PAPAAAPAPRAAAATE-PVVAPRPPRASASGLPDM 576
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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