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Conserved domains on  [gi|53828924|ref|NP_005276|]
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neuropeptides B/W receptor type 1 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor subfamily 2A protein( domain architecture ID 11606792)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters| olfactory receptor (OR) subfamily 2A protein, such as human olfactory receptor 2A2 and related proteins in other mammals and sauropsids; ORs play a central role in olfaction, the sense of smell, and belong to the class A rhodopsin-like family of seven-transmembrane G protein-coupled receptors (7TM GPCRs)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
47-318 6.53e-167

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


:

Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 465.37  E-value: 6.53e-167
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15087  10 ICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIAEHLLQQWPFGELLCKLILSIDHYNIFSSIYF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLD-DEQGRRQCVLVFPQPEAFWWRASRL 205
Cdd:cd15087  90 LTVMSVDRYLVVLATVRSRRMPYRTYRAAKIVSLCVWLLVTIIVLPFTVFAGVYsNELGRKSCVLSFPSPESLWFKASRI 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLV 285
Cdd:cd15087 170 YTLVLGFAIPVSTICILYTMMLYKLRNMRLNSNAKALDKAKKKVTLMVLVVLAVCLFCWTPFHLSTVVALTTDLPQTPLV 249
                       250       260       270
                ....*....|....*....|....*....|...
gi 53828924 286 IAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15087 250 IGISYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
 
Name Accession Description Interval E-value
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
47-318 6.53e-167

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 465.37  E-value: 6.53e-167
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15087  10 ICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIAEHLLQQWPFGELLCKLILSIDHYNIFSSIYF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLD-DEQGRRQCVLVFPQPEAFWWRASRL 205
Cdd:cd15087  90 LTVMSVDRYLVVLATVRSRRMPYRTYRAAKIVSLCVWLLVTIIVLPFTVFAGVYsNELGRKSCVLSFPSPESLWFKASRI 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLV 285
Cdd:cd15087 170 YTLVLGFAIPVSTICILYTMMLYKLRNMRLNSNAKALDKAKKKVTLMVLVVLAVCLFCWTPFHLSTVVALTTDLPQTPLV 249
                       250       260       270
                ....*....|....*....|....*....|...
gi 53828924 286 IAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15087 250 IGISYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
54-307 7.19e-53

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 174.41  E-value: 7.19e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924    54 GNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL-VLPINIADFLL-RQWPFGELMCKLIVAIDQYNTFSSLYFLTVMS 131
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLlTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924   132 ADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFA--RLDDEQGRRQCVLVFPqPEAFWWRASRLYTLV 209
Cdd:pfam00001  81 IDRYLAIVHPLRYKRR--RTPRRAKVLILVIWVLALLLSLPPLLFGwtLTVPEGNVTVCFIDFP-EDLSKPVSYTLLISV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924   210 LGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVV-ALTTDLPQTPLVIAI 288
Cdd:pfam00001 158 LGFLLPLLVILVCYTLIIRTLRKSASKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLdSLALDCELSRLLDKA 237
                         250
                  ....*....|....*....
gi 53828924   289 SYFITSLSYANSCLNPFLY 307
Cdd:pfam00001 238 LSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
51-322 2.01e-34

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 128.36  E-value: 2.01e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924   51 GLAGNSAVLYVLLRApRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVM 130
Cdd:PHA03087  54 GLVGNIIVIYVLTKT-KIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGLYYIGFYNSMNFITVM 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  131 SADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCvLVFPQPEAFWWRASRLYTL-V 209
Cdd:PHA03087 133 SVDRYIAIVHPVKSNKI--NTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLIC-CMFYNNKTMNWKLFINFEInI 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  210 LGFAIPVSTICVLYTTLLCRLHAMrldshakALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAIS 289
Cdd:PHA03087 210 IGMLIPLTILLYCYSKILITLKGI-------NKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFKSGCKAVK 282
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 53828924  290 Y-----FITS-LSYANSCLNPFLYAFLDASFRRNLRQLI 322
Cdd:PHA03087 283 YiqyalHVTEiISLSHCCINPLIYAFVSEFFNKHKKKSL 321
 
Name Accession Description Interval E-value
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
47-318 6.53e-167

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 465.37  E-value: 6.53e-167
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15087  10 ICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIAEHLLQQWPFGELLCKLILSIDHYNIFSSIYF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLD-DEQGRRQCVLVFPQPEAFWWRASRL 205
Cdd:cd15087  90 LTVMSVDRYLVVLATVRSRRMPYRTYRAAKIVSLCVWLLVTIIVLPFTVFAGVYsNELGRKSCVLSFPSPESLWFKASRI 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLV 285
Cdd:cd15087 170 YTLVLGFAIPVSTICILYTMMLYKLRNMRLNSNAKALDKAKKKVTLMVLVVLAVCLFCWTPFHLSTVVALTTDLPQTPLV 249
                       250       260       270
                ....*....|....*....|....*....|...
gi 53828924 286 IAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15087 250 IGISYFITSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
47-318 8.47e-106

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 310.77  E-value: 8.47e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd14970  10 VCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYLLGYWPFGEVMCKIVLSVDAYNMFTSIFC 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLD-DEQGRRQCVLVFPQPEAFWWRASRL 205
Cdd:cd14970  90 LTVMSVDRYLAVVHPVKSLRF--RTPRKAKLVSLCVWALSLVLGLPVIIFARTLqEEGGTISCNLQWPDPPDYWGRVFTI 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLHAMRL--DSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTP 283
Cdd:cd14970 168 YTFVLGFAVPLLVITVCYSLIIRRLRSSRNlsTSGAREKRRARRKVTRLVLVVVAVFVVCWLPFHVFQIVRLLIDPPETL 247
                       250       260       270
                ....*....|....*....|....*....|....*
gi 53828924 284 LVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd14970 248 TVVGVFLFCIALSYANSCLNPILYAFLDENFRKSF 282
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
47-316 3.48e-76

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 235.05  E-value: 3.48e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15093  10 VCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNALRHWPFGSVLCRLVLSVDGINMFTSIFC 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQ-GRRQCVLVFPQPEAFWWRASRL 205
Cdd:cd15093  90 LTVMSVDRYLAVVHPIKSARW--RRPRVAKVVNLAVWVASLLVILPVVVFAGTRENQdGSSACNMQWPEPAAAWSAGFII 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLV 285
Cdd:cd15093 168 YTFVLGFLLPLLIICLCYLLIVIKVKSAGLRAGWQQRKRSERKVTRMVVMVVVVFVICWLPFYVLQLVNVFVQLPETPAL 247
                       250       260       270
                ....*....|....*....|....*....|.
gi 53828924 286 IAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15093 248 VGVYHFVVILSYANSCANPILYGFLSDNFKK 278
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
47-316 1.77e-68

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 215.42  E-value: 1.77e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15094  10 ICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMILKYWPFGAAMCKIYMVLTSINQFTSSFT 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAF-WWRASRL 205
Cdd:cd15094  90 LTVMSADRYLAVCHPIRSMRY--RTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTIVWPDSSAVnGQKAFTL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTV--VALTTDLPQTP 283
Cdd:cd15094 168 YTFLLGFAIPLLLISVFYTLVILRLRTVGPKNKSKEKRRSHRKVTRLVLTVISVYIICWLPYWAFQVhlIFLPPGTDMPK 247
                       250       260       270
                ....*....|....*....|....*....|...
gi 53828924 284 LVIAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15094 248 WEILMFLLLTVLSYANSMVNPLLYAFLSENFRK 280
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
47-318 3.48e-66

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 209.31  E-value: 3.48e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15971  10 VCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPFLAIQVALVHWPFGKAICRVVMTVDGINQFTSIFC 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRvaGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLY 206
Cdd:cd15971  90 LTVMSIDRYLAVVHPIKSAK--WRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGRSSCTIIWPGESSAWYTGFIIY 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVI 286
Cdd:cd15971 168 TFILGFFVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFVFCWLPFYIFNVSSVSVSISPTPGLK 247
                       250       260       270
                ....*....|....*....|....*....|..
gi 53828924 287 AISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15971 248 GMFDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
47-316 1.06e-64

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 205.57  E-value: 1.06e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15089  10 VCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFT 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAesRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFA-RLDDEQGRRQCVLVFPQPEAFWWRASRL 205
Cdd:cd15089  90 LTMMSVDRYIAVCHPV--KALDFRTPAKAKLINICIWVLSSGVGVPIMVMAvTKTPRDGAVVCMLQFPSPSWYWDTVTKI 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQ-TPL 284
Cdd:cd15089 168 CVFIFAFVVPILVITVCYGLMILRLRSVRLLSGSKEKDRNLRRITRMVLVVVAAFIICWTPIHIFVIVWTLVDIDRrNPL 247
                       250       260       270
                ....*....|....*....|....*....|..
gi 53828924 285 VIAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15089 248 VVAALHLCIALGYANSSLNPVLYAFLDENFKR 279
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
47-316 1.14e-64

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 205.49  E-value: 1.14e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15092  10 VCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDIFLGFWPFGNALCKTVIAIDYYNMFTSTFT 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLY 206
Cdd:cd15092  90 LTAMSVDRYVAICHPIKALDV--RTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEEIECLVEIPTPQDYWDPVFGIC 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVI 286
Cdd:cd15092 168 VFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSKEKDRNLRRITRLVLVVVAVFVGCWTPIQIFVLAQGLGVQPSSETAV 247
                       250       260       270
                ....*....|....*....|....*....|
gi 53828924 287 AISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15092 248 AILRFCTALGYVNSSLNPVLYAFLDENFKA 277
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
50-316 7.71e-64

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 203.65  E-value: 7.71e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15091  13 VGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTM 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLVVLATAESrrVAGRTYSAARAVSLAVWGIVTLVVLPFAVFA--RLDDEQGRRQCVLVFPQPEAFWWRA-SRLY 206
Cdd:cd15091  93 MSVDRYIAVCHPVKA--LDFRTPLKAKIINICIWLLSSSVGISAIVLGgtKVREDVDSTECSLQFPDDDYSWWDTfMKIC 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVI 286
Cdd:cd15091 171 VFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSVSHSTAAV 250
                       250       260       270
                ....*....|....*....|....*....|
gi 53828924 287 AISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15091 251 SSYYFCIALGYTNSSLNPILYAFLDENFKR 280
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
47-318 4.06e-63

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 201.68  E-value: 4.06e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15970  10 VCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGSLLCRLVLSVDAINMFTSIYC 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARL-DDEQGRRQCVLVFPQPEAFWWRASRL 205
Cdd:cd15970  90 LTVLSIDRYIAVVHPIKAARY--RRPTVAKMVNLGVWVFSILVILPIIIFSNTaPNSDGSVACNMQMPEPSQRWLAVFVV 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTplv 285
Cdd:cd15970 168 YTFLMGFLLPVIAICLCYILIIVKMRVVALKAGWQQRKRSERKITLMVMMVVTVFVICWMPFYVVQLVSVFVGQHDA--- 244
                       250       260       270
                ....*....|....*....|....*....|...
gi 53828924 286 iAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15970 245 -TVSQLSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
47-316 9.02e-63

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 200.61  E-value: 9.02e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15090  10 VCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFT 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESrrVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLY 206
Cdd:cd15090  90 LCTMSVDRYIAVCHPVKA--LDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPSWYWENLLKIC 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVI 286
Cdd:cd15090 168 VFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQT 247
                       250       260       270
                ....*....|....*....|....*....|
gi 53828924 287 AISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15090 248 VSWHFCIALGYTNSCLNPVLYAFLDENFKR 277
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
47-317 1.27e-62

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 200.41  E-value: 1.27e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15974  10 VCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLATQNAISYWPFGSFLCRLVMTVDGVNQFTSIFC 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRvaGRTYSAARAVSLAVWGIVTLVVLPFAVFArlDDEQGRRQCVLVFPQPEAFWWRASRLY 206
Cdd:cd15974  90 LTVMSIDRYLAVVHPIKSTK--WRRPRVAKLINATVWTLSFLVVLPVIIFS--DVQPDLNTCNISWPEPVSVWSTAFIIY 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVI 286
Cdd:cd15974 166 TAVLGFFGPLLVICLCYLLIVIKVKSSGLRVGSTKRRKSERKVTRMVVIIVVVFVFCWLPFYMLNIVNLIVILPEEPAFV 245
                       250       260       270
                ....*....|....*....|....*....|.
gi 53828924 287 AISYFITSLSYANSCLNPFLYAFLDASFRRN 317
Cdd:cd15974 246 GVYFFVVVLSYANSCANPILYGFLSDNFKQS 276
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
47-318 4.71e-62

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 198.87  E-value: 4.71e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15972  10 VCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAQNALSYWPFGSFMCRLVMTVDAINQFTSIFC 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRvaGRTYSAARAVSLAVWGIVTLVVLPFAVFArlDDEQGRRQCVLVFPQPEAFWWRASRLY 206
Cdd:cd15972  90 LTVMSVDRYLAVVHPIRSSK--WRKPPVAKTVNATVWALSFLVVLPVVIFS--GVPGGMGTCHIAWPEPAQVWRAGFIIY 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAK--KRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPL 284
Cdd:cd15972 166 TATLGFFCPLLVICLCYLLIVVKVRSSGRRVRATSTKRRGseRKVTRMVVIVVAAFVLCWLPFYALNIVNLVCPLPEEPS 245
                       250       260       270
                ....*....|....*....|....*....|....
gi 53828924 285 VIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15972 246 LFGLYFFVVVLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
47-318 7.72e-58

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 188.04  E-value: 7.72e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLL-RQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15088  10 ICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIdGQWYFGEVMCKIITALDANNQFTSTY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQ-CVLVFPQPEAFWWRAsr 204
Cdd:cd15088  90 ILTAMSVDRYLAVVHPIRSTKY--RTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDGTTfCYVSLPSPDDLYWFT-- 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPL 284
Cdd:cd15088 166 IYHFILGFAVPLVVITVCYILILHRLARGVAPGNQSHGSSRTKRVTKMVILIVVVFIVCWLPFHVVQLVNLAMNRPTLAF 245
                       250       260       270
                ....*....|....*....|....*....|....
gi 53828924 285 VIAIsYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15088 246 EVAY-FLSICLGYANSCLNPFVYILVSENFRKRL 278
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
47-316 3.44e-54

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 178.51  E-value: 3.44e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15973  10 VCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAALQHWPFGSAMCRTVLSVDGINMFTSVFC 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFA-RLDDEQGRRQCVLVFPQPEafWWRASRL 205
Cdd:cd15973  90 LTVLSVDRYIAVVHPLRAARY--RRPTVAKMINICVWILSLLVISPIIIFAdTATRKGQAVACNLIWPHPA--WSAAFVI 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTtdLPQtpLV 285
Cdd:cd15973 166 YTFLLGFLLPVLAIGLCYILIIGKMRAVALKAGWQQRRKSEKKITRMVLMVVTVFVICWMPFYVVQLLNLF--LPR--LD 241
                       250       260       270
                ....*....|....*....|....*....|.
gi 53828924 286 IAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15973 242 ATVNHASLILSYANSCANPILYGFLSDNFRR 272
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
54-307 7.19e-53

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 174.41  E-value: 7.19e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924    54 GNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL-VLPINIADFLL-RQWPFGELMCKLIVAIDQYNTFSSLYFLTVMS 131
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLlTLPFWLVYYLNhGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924   132 ADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFA--RLDDEQGRRQCVLVFPqPEAFWWRASRLYTLV 209
Cdd:pfam00001  81 IDRYLAIVHPLRYKRR--RTPRRAKVLILVIWVLALLLSLPPLLFGwtLTVPEGNVTVCFIDFP-EDLSKPVSYTLLISV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924   210 LGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVV-ALTTDLPQTPLVIAI 288
Cdd:pfam00001 158 LGFLLPLLVILVCYTLIIRTLRKSASKQKSSERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLdSLALDCELSRLLDKA 237
                         250
                  ....*....|....*....
gi 53828924   289 SYFITSLSYANSCLNPFLY 307
Cdd:pfam00001 238 LSVTLWLAYVNSCLNPIIY 256
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
47-318 3.36e-52

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 173.17  E-value: 3.36e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFlLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd14984  10 VFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYA-ADGWVFGSFLCKLVSALYTINFYSGILF 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYL-VVLATAESRRvagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEA-FWWRASR 204
Cdd:cd14984  89 LACISIDRYLaIVHAVSALRA---RTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGSSICSYDYPEDTAtTWKTLLR 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALerakkRVTFLVVailAVCLLCWTPYHLsTVVALTTDLPQ--- 281
Cdd:cd14984 166 LLQNILGFLLPLLVMLFCYSRIIRTLLRARNHKKHRAL-----RVIFAVV---VVFFLCWLPYNI-VLLLDTLQLLGiis 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 53828924 282 ------TPLVIAISyfIT-SLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd14984 237 rscelsKSLDYALQ--VTeSLAFSHCCLNPVLYAFVGVKFRKYL 278
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
47-318 8.78e-49

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 165.08  E-value: 8.78e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd14993  10 VFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFcMPLTLLENVYRPWVFGEVLCKAVPYLQGVSVSASVL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAgrTYSAARAVSLAVWGIVTLVVLPFAVFARLD-------DEQGRRQCVLVFPQPEAF 198
Cdd:cd14993  90 TLVAISIDRYLAICYPLKARRVS--TKRRARIIIVAIWVIAIIIMLPLLVVYELEeiissepGTITIYICTEDWPSPELR 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 199 WWRAsrLYTLVLGFAIPVSTICVLYT----TLLCR---LHAMRLDSH-AKALERAKKRVTFLVVAILAVCLLCWTPYH-- 268
Cdd:cd14993 168 KAYN--VALFVVLYVLPLLIISVAYSligrRLWRRkppGDRGSANSTsSRRILRSKKKVARMLIVVVVLFALSWLPYYvl 245
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 53828924 269 -LSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd14993 246 sILLDFGPLSSEESDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
47-310 1.47e-48

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 164.00  E-value: 1.47e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd00637   8 IFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLvIPFSLVSLLLGRWWFGDALCKLLGFLQSVSLLASIL 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEafWWRASRL 205
Cdd:cd00637  88 TLTAISVDRYLAIVHPLRYRRR--FTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLT--LSKAYTI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRL-------HAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLsTVVALTTD 278
Cdd:cd00637 164 FLFVLLFLLPLLVIIVCYVRIFRKLrrhrrriRSSSSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFI-LLLLDVFG 242
                       250       260       270
                ....*....|....*....|....*....|..
gi 53828924 279 LPQTPLVIAISYFITSLSYANSCLNPFLYAFL 310
Cdd:cd00637 243 PDPSPLPRILYFLALLLAYLNSAINPIIYAFF 274
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
47-316 4.40e-48

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 163.02  E-value: 4.40e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL-VLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd14971  10 IFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLfCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSMHASIF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRL 205
Cdd:cd14971  90 TLVAMSLDRFLAVVYPLRSLHI--RTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPGNRTVCSEAWPSRAHRRAFAL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLH-AMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPL 284
Cdd:cd14971 168 CTFLFGYLLPLLLICVCYAAMLRHLWrVAVRPVLSEGSRRAKRKVTRLVLVVVVLFAACWGPIHAILLLVALGPFPLTYA 247
                       250       260       270
                ....*....|....*....|....*....|..
gi 53828924 285 VIAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd14971 248 TYALRIWAHCLAYSNSAVNPVLYAFLSEHFRK 279
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
47-318 9.96e-48

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 162.07  E-value: 9.96e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15095  10 IFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFLVCcVPFTAALYATPSWVFGDFMCKFVNYMMQVTVQATCL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDE--QGRRQ-CVLVFPQPEAFwwRA 202
Cdd:cd15095  90 TLTALSVDRYYAIVHPIRSLRF--RTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEGywYGPQTyCREVWPSKAFQ--KA 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 SRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDS---HAKALERA---KKRVTFLVVAILAVCLLCWTPYH-LSTVVAL 275
Cdd:cd15095 166 YMIYTVLLTYVIPLAIIAVCYGLILRRLWRRSVDGnnqSEQLSERAlrqKRKVTRMVIVVVVLFAICWLPNHvLNLWQRF 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 53828924 276 TTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15095 246 DPNFPETYATYALKIAALCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
47-316 8.28e-47

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 159.39  E-value: 8.28e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLlrAPRMK-TVTNLFILNLAIADELFTLVLPINIADFLL-RQWPFGELMCKLIVAIDQYNTFSSL 124
Cdd:cd14974  10 IFLLGLPGNGLVIWVA--GFKMKrTVNTVWFLNLALADFLFCLFLPFLIVYIAMgHHWPFGSVLCKLNSFVISLNMFASV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVlvFPQPEAFWWRASR 204
Cdd:cd14974  88 FLLTAISLDRCLLVLHPVWAQNH--RTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSCN--LTCVEDYDLRRSR 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTL-----VLGFAIPVSTICVLYTTLLCRLHAMRLdshakalerAKKRVTFLVVAILAVC-LLCWTPYHLSTVVALTTD 278
Cdd:cd14974 164 HKALtvirfLCGFLLPLLIIAICYSVIAVKLRRKRL---------AKSSKPLRVLLAVVVAfFLCWLPYHVFALLELVAA 234
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53828924 279 LPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd14974 235 AGLPEVVLLGLPLATGLAYFNSCLNPILYVFMGQDFRK 272
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
47-316 2.10e-45

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 155.92  E-value: 2.10e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIvaidQYNT----F 121
Cdd:cd15096  10 IFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFcVPFTATDYVLPTWPFGDVWCKIV----QYLVyvtaY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 122 SSLYFLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLP----FAVFARLDDEQGRRQCV---LVFPQ 194
Cdd:cd15096  86 ASVYTLVLMSLDRYLAVVHPITSMSI--RTERNTLIAIVGIWIVILVANIPvlflHGVVSYGFSSEAYSYCTfltEVGTA 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 195 PEAFWwrasrLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALE--RAKKRVTFLVVAILAVCLLCWTPYHLSTV 272
Cdd:cd15096 164 AQTFF-----TSFFLFSYLIPLTLICVLYMLMLRRLRRQKSPGGRRSAEsqRGKRRVTRLVVVVVVVFAICWLPIHIILL 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 53828924 273 VALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15096 239 LKYYGVLPETVLYVVIQILSNCLAYGNSCVNPILYAFLSQNFRK 282
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
47-318 2.12e-44

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 153.19  E-value: 2.12e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQ-WPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd14982  10 IFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGwWPFGDFLCRLTGLLFYINMYGSIL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAGRTYsaARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRL 205
Cdd:cd14982  90 FLTCISVDRYLAVVHPLKSRRLRRKRY--AVGVCAGVWILVLVASVPLLLLRSTIAKENNSTTCFEFLSEWLASAAPIVL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHakaLERAKKRVTFLVVAILAVCLLCWTPYHLS----TVVALT--TDL 279
Cdd:cd14982 168 IALVVGFLIPLLIILVCYSLIIRALRRRSKQSQ---KSVRKRKALRMILIVLAVFLVCFLPYHVTrilyLLVRLSfiADC 244
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53828924 280 PQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd14982 245 SARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
47-318 2.98e-43

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 150.35  E-value: 2.98e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMK---TVTNLFILNLAIADELFTLVLPINIADFLLRQ-WPFGELMCKLIVAIDQYNTFS 122
Cdd:cd15338  10 ICFLGIIGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDLLFLLGMPFLIHQLLGNGvWHFGETMCTLITALDTNSQIT 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 123 SLYFLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDD-EQGRRQCVLVFPQPEA--FW 199
Cdd:cd15338  90 STYILTVMTLDRYLATVHPIRSTKI--RTPRVAVAVICLVWILSLLSITPVWMYAGLMPlPDGSVGCALLLPNPETdtYW 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 200 WRasrLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDL 279
Cdd:cd15338 168 FT---LYQFFLAFALPLVVICVVYFKILQNMASTVAPLPQRSLRVRTKKVTRMAVAICLAFFICWAPFYILQLAHLSIDR 244
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53828924 280 PQTPLVIAISYFItSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15338 245 PSLAFLYAYNVAI-SMGYANSCINPFLYIMLSETFKRQF 282
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
50-318 4.01e-41

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 144.83  E-value: 4.01e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADfLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15180  13 LGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQ-AVHGWIFGTGLCKLAGAVFKINFYCGIFLLAC 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYL-VVLATAESRRvagRTYSAARAVSLAVWGIVTLVVLPFAVF--ARLDDEQGRRQCVLVFPQPEAFWWRASRLY 206
Cdd:cd15180  92 ISFDRYLsIVHAVQMYSR---KKPMLVHLSCLIVWLFCLLLSIPDFIFleATKDPRQNKTECVHNFPQSDTYWWLALRLL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVLGFAIPVSTICVLYTtllCRLHAMRLDSHAKalerAKKRVTFLVVAILAVCLLCWTPYHLSTVV-------ALTTDL 279
Cdd:cd15180 169 YHIVGFLLPLAVMVYCYT---SILLRLLRSSQGF----QKQRAIRVIVAVVVVFFLCWTPYNIALLVdtlidlsVLDRNC 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 53828924 280 PQ-TPLVIAISyfITS-LSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15180 242 GTeSRLDIALS--VTSsLGYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
47-318 4.36e-41

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 144.57  E-value: 4.36e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRApRMKTVTNLFILNLAIADELFTLVLPINIADFLL-RQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15339  10 LCSTGLVGNILVLFTIIRS-RKKTVPDIYVCNLAVADLVHIIVMPFLIHQWARgGEWVFGSPLCTIITSLDTCNQFACSA 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAesRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDD-EQGRRQCVLVFPQPEAFWWRAsr 204
Cdd:cd15339  89 IMTAMSLDRYIALVHPF--RLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKfRDGLESCAFNLTSPDDVLWYT-- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTLVLGFAIPVSTICVLYTTLLCRLHAM-----RLDSHAKALERAK-KRVTFLVVAILAVCLLCWTPYHLSTVVALTtd 278
Cdd:cd15339 165 LYQTITTFFFPLPLILICYILILCYTWEMyrknkKAGRYNTSIPRQRvMRLTKMVLVLVGVFLVSAAPYHVIQLVNLS-- 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 53828924 279 LPQTPLVIAISYFIT-SLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15339 243 VSQPTLAFYVSYYLSiCLSYASSSINPFLYILLSGNFRKRL 283
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
47-316 3.38e-40

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 142.17  E-value: 3.38e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMK--TVTNLFILNLAIADELFTL-VLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSS 123
Cdd:cd15098  10 IFCLGVLGNSLVITVLARVKPGKrrSTTNVFILNLSIADLFFLLfCVPFQATIYSLPEWVFGAFMCKFVHYFFTVSMLVS 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 124 LYFLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARL---DDEQGRRQCVLVFPQPEafWW 200
Cdd:cd15098  90 IFTLVAMSVDRYIAVVHSRTSSSL--RTRRNALLGVLVIWVLSLAMASPVAVHQDLvhhWTASNQTFCWENWPEKQ--QK 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 201 RASRLYTLVLGFAIPVSTICVLYTTLLCRLHAmRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLP 280
Cdd:cd15098 166 PVYVVCTFVFGYLLPLLLITFCYAKVLNHLHK-KLKNMSKKSERSKKKTAQTVLVVVVVFGISWLPHHIIHLWVEFGDFP 244
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 53828924 281 QTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15098 245 LTQASFVLRITAHCLAYANSCVNPIIYAFLSENFRK 280
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
47-316 5.71e-40

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 141.97  E-value: 5.71e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15203  10 IIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVsLPFTLIYTLTKNWPFGSILCKLVPSLQGVSIFVSTL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRrvagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGR------RQCVLVFPQpeafw 199
Cdd:cd15203  90 TLTAIAIDRYQLIVYPTRPR----MSKRHALLIIALIWILSLLLSLPLAIFQELSDVPIEilpycgYFCTESWPS----- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 200 WRASRLYT---LVLGFAIPVSTICVLYTTLLCRLH---------AMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPy 267
Cdd:cd15203 161 SSSRLIYTisvLVLQFVIPLLIISFCYFRISLKLRkrvkkkrgkRTLSSRRRRSELRRKRRTNRLLIAMVVVFAVCWLP- 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 53828924 268 hlSTVVALTTDLPQTPLVIAISYFITSL-----SYANSCLNPFLYAFLDASFRR 316
Cdd:cd15203 240 --LNLFNLLRDFEPLPQIDGRHFYLIFLichliAMSSACVNPLLYGWLNDNFRK 291
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
47-318 1.60e-39

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 140.66  E-value: 1.60e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLR-QWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15191  10 IFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGyNWLFGSVMCKICGSLLTLNLFASIF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRvagRTYSAARAVSLAVWGIVTLVVLPFAVF--ARLDDEQGRRQCVLVFPQPEAFWWRAS 203
Cdd:cd15191  90 FITCMSVDRYLAVVYPLRSQR---RRSWQARLVCLLVWVLACLSSLPTFYFrdTYYIEELGVNACIMAFPNEKYAQWSAG 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 -RLYTLVLGFAIPVSTICVLYTTLlcRLHAMRLDSHAKALERaKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLP-- 280
Cdd:cd15191 167 lALMKNTLGFLIPLIVIATCYFGI--GRHLLKTKGFGKNKQR-RDKVLKMVAAVVLAFLICWFPFHVLTFLDALARMGvi 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 53828924 281 -----QTPLVIAISYFItSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15191 244 nncwvITVIDKALPFAI-CLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-318 2.34e-38

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 137.57  E-value: 2.34e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd14999   9 MCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTIPFYVSTYFLKKWYFGDVGCRLLFSLDFLTMHASIFT 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRvagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQ----GRRQCVLVFPQPEAFwwRA 202
Cdd:cd14999  89 LTVMSTERYLAVVKPLDTVK---RSKSYRKLLAGVIWLLSLLLTLPMAIMIRLVTVEdksgGSKRICLPTWSEESY--KV 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 SRLYTLVLGFAIPVSTICVLYTTLLCRL-HAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQ 281
Cdd:cd14999 164 YLTLLFSTSIVIPGLVIGYLYIRLARKYwLSQAAASNSSRKRLPKQKVLKMIFTIVLVFWACFLPFWIWQLLYLYSPSLS 243
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53828924 282 TP--LVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd14999 244 LSprTTTYVNYLLTCLTYSNSCINPFLYTLLTKNYKEYL 282
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
47-318 4.40e-38

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 136.72  E-value: 4.40e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTlVLPIN---IADFLLRQWPFGELMCKLIVAIDQYNTFSS 123
Cdd:cd15392  10 IFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILMA-VFCVPfsfIALLILQYWPFGEFMCPVVNYLQAVSVFVS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 124 LYFLTVMSADRYLVVLATAESRrvagRTYSAARAVSLAVWGIVTLVVLPFAVFARLdDEQGRRQCVLVFPQPEafWWRA- 202
Cdd:cd15392  89 AFTLVAISIDRYVAIMWPLRPR----MTKRQALLLIAVIWIFALATALPIAITSRL-FEDSNASCGQYICTES--WPSDt 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 -SRLYTLV---LGFAIPVSTICVLYTTLLCRLHAMRLDSHAKA-----LERAKKRVTFLVVAILAVCLLCWTPYHLSTVV 273
Cdd:cd15392 162 nRYIYSLVlmiLQYFVPLAVLVFTYTRIGIVVWAKRTPGEAENnrdqrMAESKRKLVKMMITVVAIFALCWLPLNILNLV 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 53828924 274 AL--TTDLPQTPLVIaISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15392 242 GDhdESIYSWPYIPY-LWLAAHWLAMSHCCYNPFIYCWMNAKFRNGF 287
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
49-318 1.09e-37

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 135.67  E-value: 1.09e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  49 AVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADfLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15177  12 VLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTLPFAAAE-TLQGWIFGNAMCKLIQGLYAINFYSGFLFLT 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFW-WRASRLYT 207
Cdd:cd15177  91 CISVDRYVVIVRATSAHRLRPKTLFYSVLTSLIVWLLSILFALPQLIYSRVENRSELSSCRMIFPEVVSRTvKGATALTQ 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 LVLGFAIPVSTICVLYTTLLcrlhamRLDSHAKALERakKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIA 287
Cdd:cd15177 171 VVLGFAIPLIVMAVCYAAIG------RTLLAARGWER--HRALRVIAALVVAFVLFQLPYSVVLLLDTADLLATLELSCS 242
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53828924 288 ------ISYFITS-LSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15177 243 qskrkdIALLVTSgLAYVRCCLNPLLYAFVGVRFRRDI 280
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
47-316 2.77e-37

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 134.81  E-value: 2.77e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLR-QWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd14985  10 IFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANQyDWPFGAFLCKVSSYVISVNMFASIF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRL 205
Cdd:cd14985  90 LLTCMSVDRYLAIVHPVASRRL--RRRRQARVTCALIWVVACLLSLPTFLLRSLQAIENLNKTACIMLYPHEAWHFGLSL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKAleRAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQT--- 282
Cdd:cd14985 168 ELNILGFVLPLLIILTCYFHIARSLRKRYERTGKNG--RKRRKSLKIIFALVVAFLVCWLPFHFFKFLDFLAQLGAIrpc 245
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53828924 283 PLVIAISY---FITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd14985 246 FWELFLDLglpIATCLAFTNSCLNPFIYVFVDRRFRQ 282
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
47-318 7.01e-37

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 133.90  E-value: 7.01e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15207  10 IFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFcMPFTLVDNILTGWPFGDVMCKLSPLVQGVSVAASVF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRrvagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRL 205
Cdd:cd15207  90 TLVAIAVDRYRAVVHPTEPK----LTNRQAFVIIVAIWVLALAIMIPQALVLEVKEYQFFRGQTVHICVEFWPSDEYRKA 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTL---VLGFAIPVSTICVLYTTLLCRL-----HAMRLDSHAKALERAKK--RVTFLVVAILAVCLLCWTPYHLSTVVAL 275
Cdd:cd15207 166 YTTslfVLCYVAPLLIIAVLYVRIGYRLwfkpvPGGGSASREAQAAVSKKkvRVIKMLIVVVVLFALSWLPLHTVTMLDD 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 53828924 276 TTDLPQTPLVIAISY---FITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15207 246 FGNLSPNQREVLYVYiypIAHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
47-318 7.25e-37

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 133.78  E-value: 7.25e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTV--TNLFILNLAIADELFTLVLPINIADFLLR-QWPFGELMCKLIVAIDQYNTFSS 123
Cdd:cd14976  10 VFTVGLLGNLLVLYLLKSNKKLRQQseSNKFVFNLALTDLIFVLTLPFWAVEYALDfVWPFGTAMCKVVRYVTKLNMYSS 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 124 LYFLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQ-GRRQCVLVFPQPEA----- 197
Cdd:cd14976  90 IFFLTALSVTRYIAVARALKHGWI--RKAFGAFATTIAIWAAAALAAIPEAIFSTDTWSSvNHTLCLLRFPKNSSvtrwy 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 198 FWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDShakalERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTT 277
Cdd:cd14976 168 NWLGMYQLQKVVLGFFLPLGIITLSYLLLLRFLQRKRGGS-----KRRKSRVTKSVFIVVLSFFICWLPNQALSLWSALI 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 53828924 278 DLPQTPLVIAISYFITS-------LSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd14976 243 KFDDVPFSDAFFAFQTYafpvaicLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
47-318 1.95e-36

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 132.40  E-value: 1.95e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADfLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15178  10 VFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPFWAVS-VVKGWIFGTFMCKLVSLLQEANFYSGILL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRvAGRTYSaaRAVSLAVWGIVTLVVLPFAVF--ARLDDEQGRRQCVLVFPQPEAFWWR-AS 203
Cdd:cd15178  89 LACISVDRYLAIVHATRALT-QKRHLV--KFVCAGVWLLSLLLSLPALLNrdAFKPPNSGRTVCYENLGNESADKWRvVL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 RLYTLVLGFAIPVSTICVLYTTLLCRLHAMRldshakalERAKKRVTFLVVAILAVCLLCWTPYHLSTVV------ALTT 277
Cdd:cd15178 166 RILRHTLGFLLPLVVMLFCYGFTIKTLLQTR--------SFQKHRAMRVIFAVVLAFLLCWLPYNVTVLIdtlmrtKLIT 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 53828924 278 DLPQTPLVIAISYFIT-SLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15178 238 ETCELRNHVDVALYVTqILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
47-316 3.95e-36

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 131.81  E-value: 3.95e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLP---INIADFLlrQWPFGELMCKLIVAIDQYNTFSS 123
Cdd:cd15381  10 IFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPfwaINISNGF--NWPFGEFLCKSVNAVIYMNLYSS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 124 LYFLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLD--DEQGRRQCVLVFPQPeaFWWR 201
Cdd:cd15381  88 IYFLMMVSIDRYLALVKTMSSGRM--RRPACAKLNCLIIWMFGLLMSTPMIVFRTVMyfPEYNITACVLDYPSE--GWHV 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 202 ASRLYTLVLGFAIPVSTICVLYTtllCRLHAMRLDSHAKALE-RAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLP 280
Cdd:cd15381 164 ALNILLNVVGFLIPLSIITFCST---QIIQVLRNNKMQKFKEiQTERKATVLVLAVLLMFFICWLPFHIFTFLDTLHKLG 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 53828924 281 QTPL-----VIAISYFITS-LSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15381 241 LISGcrwedILDIGTQIATfLAYSNSCLNPLLYVIVGKHFRK 282
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
47-318 8.82e-36

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 130.94  E-value: 8.82e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLR-QWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15159  10 ILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLALPGRIAYYALGfDWPFGDWLCRLTALLFYINTYAGVN 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAesRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRL 205
Cdd:cd15159  90 FMTCLSVDRYIAVVHPL--RRHRLRKVKVVRYICVFVWVLVFLQTLPLLFMPMTKEMGGRITCMEYPNFEKIKRLPLILL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLH-AMRLDSHAKALERAKKRVTFLVVAILAVcLLCWTPYHLSTVVALTTDLPQTPL 284
Cdd:cd15159 168 GACVIGFGVPVGIILFCYSQITLKLCrTAKENPLTEKSGHHKKACNVILLVLLVF-VVCFSPYHLNIIQFMIRKLLYQPS 246
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 53828924 285 VIAISYFITSLSY------ANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15159 247 CSELKAFKISLQItvclmnLNCCLDPFIYFFACKGYKKKV 286
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
50-315 9.52e-36

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 131.04  E-value: 9.52e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRA-PRMKTVTNLFILNLAIADELFTLVLPINIADFLLR-QWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15190  23 LGLSGNGLVLWTVFRSkRKRRRSADTFIANLALADLTFVVTLPLWAVYTALGyHWPFGSFLCKLSSYLVFVNMYASVFCL 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQC-------VLVFPQPEAFWW 200
Cdd:cd15190 103 TGLSFDRYLAIVRSLASAKL--RSRTSGIVALGVIWLLAALLALPALILRTTSDLEGTNKVicdmdysGVVSNESEWAWI 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 201 RASRLYTLVLGFAIPVSTICVLYTTLLCRLhAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLP 280
Cdd:cd15190 181 AGLGLSSTVLGFLLPFLIMLTCYFFIGRTV-ARHFSKLRRKEDKKKRRLLKIIITLVVTFALCWLPFHLVKTLYALMYLG 259
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 53828924 281 QTPLVIAISYFI-------TSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15190 260 ILPFSCGFDLFLmnahpyaTCLAYVNSCLNPFLYAFFDPRFR 301
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
47-318 1.06e-35

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 130.54  E-value: 1.06e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15389  10 IIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITLLnTPFTLVRFVNSTWVFGKIMCHLSRFAQYCSVYVSTL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRrvagRTYSAARAVSLAVWGIVTLVVLPFAVFARL-----DDEQGRRQCVLVFPQPEAFWW 200
Cdd:cd15389  90 TLTAIALDRHRVILHPLKPR----ITPCQGVVVIAIIWIMASCLSLPHAIYQKLvefeySNERTRSRCLPSFPEPSDLFW 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 201 RASRLYTLVLGFAIPVSTICVLYTTLLCRL--HAMRLDSHAK---ALERAKKRVTFLVVAILAVCLLCWTP---YHLstV 272
Cdd:cd15389 166 KYLDLATFILQYVLPLLIIGVAYTRVAKKLwlRNAIGDVTTEqyvAQRRKKKKTIKMLMLVVLLFAICWLPlncYHV--L 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 53828924 273 VALTTDLPQTPLVIAISYFITSlsyaNSCLNPFLYAFLDASFRRNL 318
Cdd:cd15389 244 LSSHPIRSNSALFFAFHWLAMS----STCYNPFIYCWLNDSFRSEL 285
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
47-316 1.29e-35

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 130.26  E-value: 1.29e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLL-RQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15193  10 IFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALgGQWLFGEGLCKLSSFIIAVNRCSSIL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQgrrQCVlvfPQPEAFWWRASRL 205
Cdd:cd15193  90 FLTGMSVDRYLAVVKLLDSRPL--RTRRCALITCCIIWAVSLVLGIPSLVYRNLINES---VCV---EDSSSRFFQGISL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLHamRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDL----PQ 281
Cdd:cd15193 162 ATLFLTFVLPLIVILFCYCSILVRLR--RHFHGAKRTGRRRRNSLRIVFAIVTAFVLSWLPFNTLKAVRLLLELgggvLP 239
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53828924 282 TPLVIAISYFI---TSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15193 240 CHTTVAIRQGLtitACLAFVNSCVNPLIYSLLDRHFRR 277
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
47-318 2.20e-35

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 129.61  E-value: 2.20e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVL-LRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLR-QWPFGELMCKLIVAIDQYNTFSSL 124
Cdd:cd15925  10 VCAIGLLGNLAVMYLLrNCARRAPPPIDVFVFNLALADFGFALTLPFWAVESALDfHWPFGGAMCKMVLTATVLNVYASV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAESRRVAgrTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFpqPEAFWWRASR 204
Cdd:cd15925  90 FLLTAMSVTRYWVVASAAGPGTHL--STFWAKIITLALWAAALLATVPTAIFATEGEVCGVELCLLKF--PSNYWLGAYH 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILavcLLCWTPYHLSTVVALTTDLPQTPL 284
Cdd:cd15925 166 LQRVVVAFVVPLGVITTSYLLLLSFLQQHKVNQNNRQRQSVIARSVRLVVASF---FLCWFPNHVVTFWGVLVKFRAVPW 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 53828924 285 VIAISYF-------ITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15925 243 NSTFYFIhtyvfpvTTCLAHSNSCLNPVLYCLMRREFRQAL 283
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
47-315 2.53e-35

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 129.49  E-value: 2.53e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFlLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15172  10 ICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLTLPFWAVYE-AHQWIFGNFSCKLLRGIYAINFYSGMLL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAfwWRASRLY 206
Cdd:cd15172  89 LACISVDRYIAIVQATKSFRLRSRTLAYSKLICAAVWLLAILISLPTFIFSEVYDFGLEEQYVCEPKYPKN--STAIMWK 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVL------GFAIPVSTICVLYTTLLCRLHamrldsHAKALERAKK-RVtflVVAILAVCLLCWTPYHLSTVVALT--- 276
Cdd:cd15172 167 LLVLslqvslGFFIPLLVMIFCYSFIIKTLL------QAQNSQRHKAvRV---VVAVVLVFLVCQVPYNIVLLIEAInlg 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 53828924 277 -TDLPQTPLVIAISYFIT-SLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15172 238 eQQSCSSEKAVAYAKTITeCLAFFHCCLNPVLYAFIGVKFR 278
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
47-318 2.92e-35

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 129.55  E-value: 2.92e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15202  10 IIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMITLFnTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVHVSAY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRrvagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQG-----RRQCVLVFPQPEAFWW 200
Cdd:cd15202  90 TLTAIAVDRYQAIMHPLKPR----ISKTKAKFIIAVIWTLALAFALPHAICSKLETFKYsedivRSLCLEDWPERADLFW 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 201 RASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAK-----ALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVAL 275
Cdd:cd15202 166 KYYDLALFILQYFLPLLVISFAYARVGIKLWASNMPGDATteryfALRRKKKKVIKMLMVVVVLFALCWLPFNIYVLLLS 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 53828924 276 TTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15202 246 SKPDYLIKTINAVYFAFHWLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
50-318 3.03e-35

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 129.02  E-value: 3.03e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFlLRQWPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15182  13 LSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWASYH-SSGWIFGEILCKAVTSIFYIGFYSSILFLTL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLVV---LATAESRRVAgrtysAARAVSLAVWGIVTLVVLPFAVFARLDdeqgRRQCVLVFPQPEAFWWRASRLY 206
Cdd:cd15182  92 MTIDRYLAVvhpLSALRSRKLR-----YASLVSVAVWVISILASLPELILSTVM----KSDEDGSLCEYSSIKWKLGYYY 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVLGFAIPVSTICVLYTTLLCRLHAMRLdshakaleRAKKRVTFLVVAILAVCLLCWTPYHlstVVALTTDLPQTPLVI 286
Cdd:cd15182 163 QQNLFFLIPLGIIVYCYVRILQTLMRTRT--------MRKHRTVKLIFVIVLVFFLSWAPYN---IVIFLRSLKDLTIPI 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 53828924 287 A-------ISYFIT-SLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15182 232 CecskqldYAFYICrNIAFSHCCLNPVFYVFVGVKFRNHL 271
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
50-318 4.60e-35

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 128.76  E-value: 4.60e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINiADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15187  13 FGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQ-AYYLLDQWVFGNAMCKIVSGAYYIGFYSSMFFITL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLV 209
Cdd:cd15187  92 MSIDRYLAIVHAVYALKV--RTASHGTILSLALWLVAILASVPLLVFYQVASEDGRLQCIPFYPGQGNSWKVFTNFEVNI 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 210 LGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALErakkrvtfLVVAILAVCLLCWTPYHL-----STVVALTTDLPQTPL 284
Cdd:cd15187 170 LGLLIPFSILIFCYHNILRNLRRCHNQNKTKAIK--------LVFIVVIVFFLFWTPFNVvlfldSLHSLHIIDGCQNSQ 241
                       250       260       270
                ....*....|....*....|....*....|....*
gi 53828924 285 VIAISYFIT-SLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15187 242 RLTLALHLTeTISFTHCCLNPVIYAFVGEKFKKHL 276
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
50-315 9.36e-35

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 127.39  E-value: 9.36e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADeLFTLV--LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15001  12 LGLIGNSLVIFVVARFRRMRSVTNVFLASLATAD-LLLLVfcVPLKTAEYFSPTWSLGAFLCKAVAYLQLLSFICSVLTL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQ-----CVLVFPQPEafWWRA 202
Cdd:cd15001  91 TAISIERYYVILHPMKAKSF--CTIGRARKVALLIWILSAILASPVLFGQGLVRYESENGvtvyhCQKAWPSTL--YSRL 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 SRLYTLVLGFAIPVSTICVLYTTllcrlhamrldshakaleRAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQ- 281
Cdd:cd15001 167 YVVYLAIVIFFIPLIVMTFAYAR------------------DTRKQVIKMLISVVVLFAVCWGPLLIDNLLVSFDVISTl 228
                       250       260       270
                ....*....|....*....|....*....|....*
gi 53828924 282 -TPLVIAISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15001 229 hTQALKYMRIAFHLLSYANSCINPIIYAFMSKNFR 263
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
48-315 1.15e-34

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 127.19  E-value: 1.15e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  48 CAVGLAGNSAVLYVllRAPRMK-TVTNLFILNLAIADELFTLVLPINIADFLLR-QWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15115  11 FLLGVPGNGLVIWV--AGLKMKrTVNTIWFLNLAVADLLCCLSLPFSIAHLLLNgHWPYGRFLCKLLPSIIVLNMFASVF 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRvaGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFpqpeafwWRASRL 205
Cdd:cd15115  89 TLTAISLDRFLLVIKPVWAQN--HRSVLLACLLCGCIWILALLLCLPVFIYRTTVTDGNHTRCGYDF-------LVAITI 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRlhaMRLDSHAKALERAKKrvtfLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLV 285
Cdd:cd15115 160 TRAVFGFLLPLLIIAACYSFIAFR---MQRGRFAKSQSKTFR----VIIAVVVAFFVCWAPYHIIGILSLYGDPPLSKVL 232
                       250       260       270
                ....*....|....*....|....*....|
gi 53828924 286 IAISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15115 233 MSWDHLSIALAYANSCLNPVLYVFMGKDFK 262
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
51-322 2.01e-34

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 128.36  E-value: 2.01e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924   51 GLAGNSAVLYVLLRApRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVM 130
Cdd:PHA03087  54 GLVGNIIVIYVLTKT-KIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYILFQWSFGEFACKIVSGLYYIGFYNSMNFITVM 132
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  131 SADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCvLVFPQPEAFWWRASRLYTL-V 209
Cdd:PHA03087 133 SVDRYIAIVHPVKSNKI--NTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLIC-CMFYNNKTMNWKLFINFEInI 209
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  210 LGFAIPVSTICVLYTTLLCRLHAMrldshakALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAIS 289
Cdd:PHA03087 210 IGMLIPLTILLYCYSKILITLKGI-------NKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFKSGCKAVK 282
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 53828924  290 Y-----FITS-LSYANSCLNPFLYAFLDASFRRNLRQLI 322
Cdd:PHA03087 283 YiqyalHVTEiISLSHCCINPLIYAFVSEFFNKHKKKSL 321
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
47-316 2.49e-34

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 126.81  E-value: 2.49e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLP---INIADFLlrQWPFGELMCKLIVAIDQYNTFSS 123
Cdd:cd15189  10 LCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPfwaMNILNQF--NWPFGELLCRVVNGVIKVNLYTS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 124 LYFLTVMSADRYLVVLATAESRRVAGRTYsaARAVSLAVWGIVTLVVLPFAVFARLDD--EQGRRQCVLVFPQPEafwWR 201
Cdd:cd15189  88 IYLLVMISQDRYLALVKTMAARRLRRRRY--AKLICVLIWVVGLLLSIPTFLLRKIKAipDLNITACVLLYPHEA---WH 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 202 ASRLYTL-VLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKalERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLP 280
Cdd:cd15189 163 FAHIVLLnIVGFLLPLLVITFCNYNILQALRTREESTRCE--DRNDSKATALVLAVTLLFLVCWGPYHFFTFLDFLFDVG 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 53828924 281 -----QTPLVIAISYFITS-LSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15189 241 vldecFWEHFIDIGLQLAVfLAFSNSCLNPVLYVFVGRYFRR 282
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
47-318 2.59e-34

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 126.80  E-value: 2.59e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFL-LRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd14987  10 IFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVqHNQWPMGEFTCKITHLIFSINLFGSIF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYL-VVLATAESRRVAGRTysaARAVSLAVWGIVTLVVLPFAVFARL--DDEQGRRQCVLVFPQpEAFW-WR 201
Cdd:cd14987  90 FLTCMSVDRYLsVTLFGNTSSRRKKIV---RRIICVLVWLLAFVASLPDTYFLKTvtSPSNNETYCRSFYPE-ESFKeWL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 202 AS-RLYTLVLGFAIPVSTICVLYTTLLCRLHAmrldshakALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLP 280
Cdd:cd14987 166 IGmELVSIVLGFVIPFPIIAVFYFLLARAISA--------SSDQERKSSRKIIFSYVVVFLVCWLPYHTVVLLDILSFLH 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 53828924 281 QTPLVIAISYFITS-------LSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd14987 238 LIPFSCQLENFLYAalhvtqcFSLVHCCVNPILYSFINRNYRYEL 282
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
47-316 3.42e-34

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 125.75  E-value: 3.42e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd14967   9 IILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVaLLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCTASIL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWwrasrL 205
Cdd:cd14967  89 NLCAISLDRYLAITRPLRYRQL--MTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTPNKIYV-----L 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLhamrldshakaleRAKKRVTFLVVAILAVCLLCWTPYHLSTVV-ALTTDLPQTPL 284
Cdd:cd14967 162 VSSVISFFIPLLIMIVLYARIFRVA-------------RRELKAAKTLAIIVGAFLLCWLPFFIIYLVsAFCPPDCVPPI 228
                       250       260       270
                ....*....|....*....|....*....|..
gi 53828924 285 VIAISYFitsLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd14967 229 LYAVFFW---LGYLNSALNPIIYALFNRDFRR 257
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
47-316 9.02e-34

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 125.51  E-value: 9.02e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQ-WPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15168  10 VFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDhWIFGDFMCKLVRFLFYFNLYGSIL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAGRTYsaARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRL 205
Cdd:cd15168  90 FLTCISVHRYLGICHPLRSLGKLKKRH--AVAISVAVWILVLLQLLPILFFATTGRKNNRTTCYDTTSPEELNDYVIYSM 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLhAMRLDSHAKALERAKK-RVTFLVVAILAVCLLcwtPYHLSTVVALT------TD 278
Cdd:cd15168 168 VLTGLGFLLPLLIILACYGLIVRAL-IRKLGEGVTSALRRKSiRLVIIVLALFAVCFL---PFHVTRTINLAarllsgTA 243
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53828924 279 LPQTPLVIAISYFIT-SLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15168 244 SCATLNGIYVAYKVTrPLASLNSCLNPLLYFLAGDKFRR 282
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
47-316 1.96e-33

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 124.44  E-value: 1.96e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15393  10 ISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFsIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVNVSVF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAgrtYSAARAVSLaVWGIVTLVVLPFAVFAR---LDDEQG---RRQCVLVFPQPEafW 199
Cdd:cd15393  90 TLTVIAVDRYRAVIHPLKARCSK---KSAKIIILI-IWILALLVALPVALALRveeLTDKTNngvKPFCLPVGPSDD--W 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 200 WRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMR-----LDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVA 274
Cdd:cd15393 164 WKIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKapgnaQDVRDDEILKNKKKVIKMLIIVVALFALCWLPLQTYNLLN 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 53828924 275 LTTDLPQTPLVIAISYFITS-LSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15393 244 EIKPEINKYKYINIIWFCSHwLAMSNSCYNPFIYGLYNEKFKR 286
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
52-316 2.34e-33

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 124.04  E-value: 2.34e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVM 130
Cdd:cd15206  15 VVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFcMPFTLVGQLLRNFIFGEVMCKLIPYFQAVSVSVSTFTLVAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 131 SADRYLVVLATAESRRvaGRTYSAARAVSLAVWGIVTLVVLPFAVFARLD--DEQGRRQCVLVFP--QPEAFWWrasrLY 206
Cdd:cd15206  95 SLERYFAICHPLKSRV--WQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIpmSRPGGHKCREVWPneIAEQAWY----VF 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVLGFAIPVSTICVLYtTLLCRlhamrldshakALERAKKRVTFLVVAILAVCLLCWTP-YHLSTVVALTTDLPQTPLV 285
Cdd:cd15206 169 LDLMLLVIPGLVMSVAY-GLISW-----------TLLEAKKRVIRMLFVIVVEFFICWTPlYVINTWKAFDPPSAARYVS 236
                       250       260       270
                ....*....|....*....|....*....|.
gi 53828924 286 IAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15206 237 STTISLIQLLAYISSCVNPITYCFMNKRFRQ 267
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
47-316 4.18e-33

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 123.72  E-value: 4.18e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLlrAPRMK-TVTNLFILNLAIADELFTLVLPINIADFLLR-QWPFGELMCKLIVAIDQYNTFSSL 124
Cdd:cd15116  10 VFVLGVLGNGLVIFIT--GFKMKkTVNTVWFLNLAVADFLFTFFLPFSIAYTAMDfHWPFGRFMCKLNSFLLFLNMFTSV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAESRRvaGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQ--CVLVFP------QPE 196
Cdd:cd15116  88 FLLTVISIDRCISVVFPVWSQN--HRSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSQNNNKiiCFNNFSlsgdnsSPE 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 197 AFWWRASRLYTLV-----LGFAIPVSTICVLYTTLLCRLHAMRLdshakalerAKKRVTF-LVVAILAVCLLCWTPYHLS 270
Cdd:cd15116 166 VNQLRNMRHQVMTitrflLGFLIPFTIIICCYAAIVLKLKRNRL---------AKSSKPFkIIAAVIVTFFLCWAPYHIL 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 53828924 271 TVVAL-TTDLPQTPLVIAISyFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15116 237 NLLEMeATRSPASVFKIGLP-ITSSLAFINSCLNPILYVFMGQDFKK 282
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
50-318 8.62e-33

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 122.92  E-value: 8.62e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVL-LRAPRmkTVTNLFILNLAIADELFTLVLPINIADFLL-RQWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15117  13 LGTLGNGLVIWVTgFRMTR--TVTTVCFLNLAVADFAFCLFLPFSVVYTALgFHWPFGWFLCKLYSTLVVFNLFASVFLL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLATAESRRvaGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVF------PQPEAFW-- 199
Cdd:cd15117  91 TLISLDRCVSVLWPVWARN--HRTPARAALVAVGAWLLALALSGPHLVFRDTRKENGCTHCYLNFdpwnetAEDPVLWle 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 200 -----WRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLdSHAkaleRAKKRVTFLVVAILavcLLCWTPYHL----S 270
Cdd:cd15117 169 tvvqrLSAQVITRFVLGFLVPLVIIGGCYGLIAARLWREGW-VHS----SRPFRVLTAVVAAF---FLCWFPFHLvsllE 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 53828924 271 TVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15117 241 LVVILNQKEDLNPLLILLLPLSSSLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
47-318 3.19e-32

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 121.45  E-value: 3.19e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLR-QWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15921  10 IFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNsHWPFGDIACRIILYVLYVNMYSSIY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAgrTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCvLVFPQPEAFWWRASRL 205
Cdd:cd15921  90 FLTALSVFRYLALVWPYLYLRVQ--THSVAGIICGLIWILMGLASSPLLFAKSKQHDEGSTRC-LELAHDAVDKLLLINY 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLhaMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTP-- 283
Cdd:cd15921 167 VTLPVGFVVPFMTVIFCYIFIIKNL--LKPSPALGRTRPSRRKACALIIISLGIFLVCFLPYHIVRTIHLITERQIKEsc 244
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53828924 284 ---LVIAISYFIT-SLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15921 245 gyiLRVRKAAVITlCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
47-318 4.61e-32

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 121.01  E-value: 4.61e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLR-QWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15158  10 ITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKgQWLFGDFLCRISSYALYVNLYCSIY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAgrTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCvlvFPQPEAFWWRASRL 205
Cdd:cd15158  90 FMTAMSFTRFLAIVFPVQNLNLV--TVKKARIVCVGIWIFVTLTSSPFLMSGSHDTETNKTKC---FEPPQSNQQLTKLL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 ----YTLVLGFAIPVSTICVLYT----TLLCRLHAMR--LDSHAKALErakkrvtfLVVAILAVCLLCWTPYHLSTVVAL 275
Cdd:cd15158 165 vlnyISLVVGFIIPFLVILICYAmiirTLLKNTMKARkqQSSRKKAIR--------MIIIVLLAFLVSFMPYHIQRTIHL 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 53828924 276 TTDLPQTP-----LVIAISYFIT-SLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15158 237 HFLSRKDStceevLYMQKSVVITlCLAAANCCFDPLLYFFSGENFRRRL 285
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
47-318 1.22e-31

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 119.49  E-value: 1.22e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADfLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15179  10 IFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVD-AAANWYFGNFLCKAVHVIYTVNLYSSVLI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRAS-RL 205
Cdd:cd15179  89 LAFISLDRYLAIVHATNSQRP--RKLLAEKVVYVGVWLPALLLTVPDLVFAKVSELDDRYICDRIYPEDTFELWVVAfRF 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLhamrldSHAKALERAKKRVTflVVAILAVCLLCWTPYHLST---------VVALT 276
Cdd:cd15179 167 QHILVGLVLPGLVILTCYCIIISKL------SHSKGHQKRKALKT--TVILILAFFACWLPYYIGIsidtfmlleIIKQS 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 53828924 277 TDLPQTpLVIAISyfIT-SLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15179 239 CEMEQT-VHKWIS--ITeALAFFHCCLNPILYAFLGAKFKTSA 278
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
47-318 1.60e-31

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 119.46  E-value: 1.60e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLR-QWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15192  10 IFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMEyHWPFGNFLCKIASALVSFNLYASVF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVF--ARLDDEQGRRQCVLVFPQPEAFWWRAS 203
Cdd:cd15192  90 LLTCLSIDRYLAIVHPMKSRLR--RTLVVARVTCIVIWLLAGVASLPAIIHrdVFFIENTNITVCAFHYPSQNSTLLVGL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 RLYTLVLGFAIPVSTICVLYTTLLCRLhamrldSHAKALERAKKR---VTFLVVAILAVCLLCWTPYHLSTV------VA 274
Cdd:cd15192 168 GLMKNLLGFLIPFLIILTCYTLIGKAL------KKAYEIQRNKPRndeIFKMIMAVVLFFFFCWIPHQIFTFldvliqLK 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 53828924 275 LTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15192 242 VIQDCHIADIVDTAMPFTICIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
47-316 2.44e-31

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 118.77  E-value: 2.44e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRA-PRMKTVTNLFILNLAIADELFTL-VLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSL 124
Cdd:cd15097  10 IFLLGTVGNSLVLAVLLRSgQSGHNTTNLFILNLSVADLCFILfCVPFQATIYSLEGWVFGSFLCKAVHFFIYLTMYASS 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVlvfPQPEAFWWRASR 204
Cdd:cd15097  90 FTLAAVSVDRYLAIRYPLRSREL--RTPRNAVAAIALIWGLSLLFAGPYLSYYDLIDYANSTVCM---PGWEEARRKAMD 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTLVLGFAIPVSTICVLYTTLLCRL-HAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTP 283
Cdd:cd15097 165 TCTFAFGYLIPVLVVSLSYTRTIKYLwTAVDPLEAMSESKRAKRKVTKMIIIVTALFCLCWLPHHVVILCYLYGDFPFNQ 244
                       250       260       270
                ....*....|....*....|....*....|...
gi 53828924 284 LVIAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15097 245 ATYAFRLLSHCMAYANSCLNPIVYALVSKHFRK 277
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
47-316 2.72e-31

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 118.91  E-value: 2.72e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15927  10 IFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTcVPFTSTIYTLDSWPFGEFLCKLSEFLKDTSIGVSVF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAGRTYSAARAVSlaVWGIVTLVVLPFAVFARLD--DEQGRRQCVLVFPQPEAFWWRAS 203
Cdd:cd15927  90 TLTALSADRYFAIVNPMRKHRSQATRRTLVTAAS--IWIVSILLAIPEAIFSHVVtfTLTDNQTIQICYPYPQELGPNYP 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 RLYTL---VLGFAIPVSTICVLYTTLLCRLHAMRLD------SHAKALERAKKRVTFLVVAILAVCLLCWTPYHlstVVA 274
Cdd:cd15927 168 KIMVLlrfLVYYLIPLLIIGVFYVLMARHLIRSTRNigsgqnQAAQRQIEARKKVAKTVLAFVVLFAVCWLPRH---VFM 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 53828924 275 LTTDLPQTPL--------VIAISYFItsLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15927 245 LWFHFAPNGLvdynafwhVLKIVGFC--LSFINSCVNPVALYLLSGSFRR 292
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
50-318 2.97e-31

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 118.28  E-value: 2.97e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVL-LRAPRmkTVTNLFILNLAIADELFTLVLPINIADFLLR-QWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15114  13 VGVPGNALVAWVTgFEAKR--SVNAVWFLNLAVADLLCCLSLPILAVPIAQDgHWPFGAAACKLLPSLILLNMYASVLLL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLvvLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQ--GRRQCVLVFPQPEAFWWrASRL 205
Cdd:cd15114  91 TAISADRCL--LVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPSFIYRRIHQEHfpEKTVCVVDYGGSTGVEW-AVAI 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLHAMRLDshakalerAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDlPQTPL- 284
Cdd:cd15114 168 IRFLLGFLGPLVVIASCHGVLLVRTWSRRRQ--------KSRRTLKVVTAVVVGFFLCWTPYHVVGLIIAASA-PNSRLl 238
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 53828924 285 --VIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15114 239 anALKADPLTVSLAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
47-318 5.76e-31

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 118.07  E-value: 5.76e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVL-LRAPRMKTVTNLFILNLAIADELFTLVLPI----NIADFllrQWPFGELMCKLIVAIDQYNTF 121
Cdd:cd15926  10 VCALGLVGNLLVLYLMkSKQGWKKSSINLFVTSLAVTDFQFVLTLPFwaveNALDF---TWLFGKAMCKIVSYVTAMNMY 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 122 SSLYFLTVMSADRYLVVLATAESRRVAGRTysAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEA---F 198
Cdd:cd15926  87 ASVFFLTAMSVARYHSVASALKSKRRRGCC--SAKWLCVLIWVLAILASLPNAIFSTTATVSNEELCLVKFPDNRGnaqF 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 199 WWRASRLYTLVLGFAIPVSTICVLYtTLLCRLHAMRLDSHAKALERAK--KRVTFLVVAIlavcLLCWTPYHLSTVVALT 276
Cdd:cd15926 165 WLGLYHAQKVLLGFLIPLGIISLCY-LLLVRFITDKNITGSSTKRRSKvtKSVTIVVLSF----FLCWLPNQALTTWGIL 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 53828924 277 TDLPQTPLviAISYFITS---------LSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15926 240 IKLNVVHF--SYEYFTTQvyifpitvcLAHSNSCLNPILYCLMRREFRKAL 288
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
47-318 1.44e-30

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 116.77  E-value: 1.44e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLP---INIADfllrQWPFGELMCKLIVAIDQYNTFSS 123
Cdd:cd15174  10 IFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLPfwaTAASS----GWVFGTFLCKVVNSMYKINFYSC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 124 LYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRAS 203
Cdd:cd15174  86 MLLLTCISVDRYIAIVQATKAHNSKNKRLLYSKLVCFFVWLLSTILSLPEILFSQSKEEESVTTCTMVYPSNESNRFKVA 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 RLYTLV-LGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALErakkrvtfLVVAILAVCLLCWTPYHLSTVV------ALT 276
Cdd:cd15174 166 VLALKVtVGFFLPFVVMVICYTLIIHTLLQAKRFQKHKALK--------VIIAVVTVFVLSQLPYNSILLIktinayNIT 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 53828924 277 TDLPQTPLVIAISYFIT-SLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15174 238 ITDCATSQNLDIAGQVTqSIAFLHSCLNPFLYVFVGVRFRKDL 280
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
50-318 4.36e-30

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 115.31  E-value: 4.36e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15185  13 VGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYVRWNNWVFGHGMCKLLSGFYYLGLYSEIFFIIL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRasRLYTL- 208
Cdd:cd15185  93 LTIDRYLAIVHAVFALRA--RTVTFGIITSIITWGLAVLAALPEFIFYETQELFEEFLCSPLYPEDTEDSWK--RFHALr 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 209 --VLGFAIPVSTICVLYTTLLCRLhaMRLDShakaleRAKKRVTFLVVAILAVCLLCWTPYHLSTVVA------LTTDLP 280
Cdd:cd15185 169 mnIFGLALPLLIMVICYTGIIKTL--LRCPS------KKKYKAIRLIFVIMVVFFIFWTPYNLVLLLSafqsifFETDCE 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53828924 281 QTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15185 241 RSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKYL 278
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
47-317 5.37e-30

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 115.61  E-value: 5.37e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd14992  10 IILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFcTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYASSL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLddEQGRRQCVLVFPQPEAFWWRASRL 205
Cdd:cd14992  90 TLTAIAFDRYFAIIHPLKPRHR--QSYTTTVIIIITIWVVSLLLAIPQLYYATT--EVLFSVKNQEKIFCCQIPPVDNKT 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 Y-------TLVLGFAIPVSTICVLYTTLLCRLHAMRL------DSHAKALeRAKKRVTFLVVAILAVCLLCWTPYHLSTV 272
Cdd:cd14992 166 YekvyfllIFVVIFVLPLIVMTLAYARISRELWFRKVpgfsikEVERKRL-KCKRRVIKMLVCVVVLFVICWLPFHLFFL 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 53828924 273 VA-LTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRN 317
Cdd:cd14992 245 LRdFFPLIMKEKHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFRKN 290
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
51-318 6.10e-30

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 115.23  E-value: 6.10e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  51 GLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLrQWPFGELMCKLIVAIDQYNTFSSLYFLTVM 130
Cdd:cd15181  14 GVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESIA-GWVFGTFLCKLVGAIHKLNFYCSSLLLACI 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 131 SADRYLVVLAtaesrrvAGRTYSAARAVS-----LAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQ---PEAFWWRA 202
Cdd:cd15181  93 SVDRYLAIVH-------AIHSYRHRRLRSvhltcGSIWLVCFLLSLPNLVFLEVETSTNANRTSCSFHQygiHESNWWLT 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 SRLYTLVLGFAIPVSTICVLYTTLlcrLHAMRLDSHAKALERAkKRVTFLVVAILavcLLCWTPYHLSTVVALTTDLP-- 280
Cdd:cd15181 166 SRFLYHVVGFFLPLLIMGYCYATI---VVTLCQSSRRLQKQKA-IRVAILVTLVF---CLCWLPYNIVIFLDTLDDLKav 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 53828924 281 ------QTPLVIAISyFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15181 239 vkncklNDLLDAAIT-VTESLGFSHCCLNPILYAFIGVKFRNDL 281
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
47-316 7.33e-30

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 115.00  E-value: 7.33e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd14969  10 IGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVgYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSIS 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVV----LATAESRRVAGrtysaarAVSLAVWGIVTLV-VLPFAVFARLDDEQGRRQCVLVFPQPEAfww 200
Cdd:cd14969  90 TLAALAFERYLVIvrplKAFRLSKRRAL-------ILIAFIWLYGLFWaLPPLFGWSSYVPEGGGTSCSVDWYSKDP--- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 201 rASRLYT---LVLGFAIPVSTICVLYTTLLCRLHAM-------RLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYH-L 269
Cdd:cd14969 160 -NSLSYIvslFVFCFFLPLAIIIFCYYKIYRTLRKMskraarrKNSAITKRTKKAEKKVAKMVLVMIVAFLIAWTPYAvV 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 53828924 270 STVVALTTDLPQTPLVIAISYFITSLSyanSCLNPFLYAFLDASFRR 316
Cdd:cd14969 239 SLYVSFGGESTIPPLLATIPALFAKSS---TIYNPIIYVFMNKQFRR 282
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
47-318 2.34e-29

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 113.39  E-value: 2.34e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPInIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15186  10 VFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATLPF-WTHYLINEWGLHNAMCKLTTAFFFIGFFGGIFF 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRvaGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEqgrrQCVLVFPQP-EAFWWRASRL 205
Cdd:cd15186  89 ITVISIDRYLAIVLAANSMN--NRTVQHGVTISLGVWAAAILVAVPQFMFTKMKEN----ECLGDYPEVlQEIWPVLRNV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALerakkRVTFLVVAILavcLLCWTPYHLST---VVALTTDLPQT 282
Cdd:cd15186 163 ELNFLGFLLPLLIMSYCYFRIIQTLFSCKNHKKARAI-----KLILLVVIVF---FLFWTPYNVMIfleTLKLYDFFPSC 234
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53828924 283 PLVIAISYFIT---SLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15186 235 DMKKDLRLALSvteTIAFSHCCLNPLIYAFAGEKFRRYL 273
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
49-315 4.30e-29

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 113.16  E-value: 4.30e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  49 AVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQ-WPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15390  12 LVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNdWPFGLFYCKFSNFVAITTVAASVFTL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVV---LATAESRRVagrtysaARAVSLAVWGIVTLVVLPFAVFARLD-----DEQGRRQCVLVFpqPEAFW 199
Cdd:cd15390  92 MAISIDRYIAIvhpLRPRLSRRT-------TKIAIAVIWLASFLLALPQLLYSTTEtyyyyTGSERTVCFIAW--PDGPN 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 200 WRASRLYTL---VLGFAIPVSTICVLYTTLLCRLHAMRL--DSHAKALE--RAKKRVT---FLVVAILAVcllCWTPYHL 269
Cdd:cd15390 163 SLQDFVYNIvlfVVTYFLPLIIMAVAYTRVGVELWGSKTigENTPRQLEsvRAKRKVVkmmIVVVVIFAI---CWLPYHL 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 53828924 270 STVVA-LTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15390 240 YFILTyLYPDINSWKYIQQIYLAIYWLAMSNSMYNPIIYCWMNKRFR 286
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
54-316 4.63e-29

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 112.75  E-value: 4.63e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  54 GNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQ--WPFGELMCKLIvaidQYNTFSSLYF---- 126
Cdd:cd15204  17 GNLLLIAVLARYKKLRTLTNLLIANLALSDFLVAVFcLPFEMDYYVVRQrsWTHGDVLCAVV----NYLRTVSLYVstna 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLataeSRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQ--CVLVFPQPEAFWWRASR 204
Cdd:cd15204  93 LLVIAIDRYLVIV----HPLKPRMKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYANQGKifCGQIWPVDQQAYYKAYY 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTLVLGFAIPVSTICVLYTTLLCRLHAMRL-----DSHAKALERAKKRVTFLVVaILAVCLLCWTPYHlstVVALTTD- 278
Cdd:cd15204 169 LFLFVLEFVLPVLIMTLCYLRIVRKVWFRRVpgqqtEQIRRRLRRRRRKVRLLVV-ILTAFVLCWAPYY---GYAIVRDf 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 53828924 279 ----LPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15204 245 fptlLSKEKLNTTIFYIVEALAMSNSMINTVVYVAFNNNIRK 286
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
50-318 1.65e-28

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 111.12  E-value: 1.65e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15183  13 IGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFWIDYKLKDDWIFGDAMCKFLSGFYYLGLYSEIFFIIL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLVVLATAESRRvaGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTL- 208
Cdd:cd15183  93 LTIDRYLAIVHAVFALR--ARTVTFGIITSIITWALAILASMPCLYFFKSQWEFTHHTCSAHFPRKSLIRWKRFQALKLn 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 209 VLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALErakkrvtfLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLV--- 285
Cdd:cd15183 171 LLGLILPLLVMIICYTGIINILLRRPNEKKAKAVR--------LIFVITLLFFLLWTPYNLAAFVSAFQDVLFTPSCeqs 242
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 53828924 286 --IAISYFITS-LSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15183 243 qqLDLALQVTEvIAYTHCCVNPVIYVFVGERFRKYL 278
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
50-318 2.00e-28

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 111.10  E-value: 2.00e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINI-ADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15194  13 VGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVdKEVVLGPWRSGSFLCKGSSYIISVNMYCSVFLLT 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWrasRLYTL 208
Cdd:cd15194  93 CMSLDRYLAIVLPLVSRKF--RTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYCNEDAGTPSKVIF---SLVSL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 209 VLGFAIPVSTICVLYTTLLCRL--HAMRLDSHAKALERAKKrVTFLVVAILavcLLCWTPYHLSTVVALTTDLPQtpLVI 286
Cdd:cd15194 168 IVAFFLPLLSILTCYCTIIWKLchHYQKSGKHQKKLRKSIK-IVFIVVAAF---VFSWMPFNLFKALAIASGLQV--EVT 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 53828924 287 AISYFI--------TSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15194 242 CLPYTLaqlgmevsAPLAFANSCANPFIYYFFDRYIRRAI 281
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
47-318 2.30e-28

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 110.96  E-value: 2.30e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLL-RAPRMK-TVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSS 123
Cdd:cd15002   9 ICLLGFAGNLMVIGILLnNARKGKpSLIDSLILNLSAADLLLlLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHACMAAK 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 124 LYFLTVMSADRYLVVLATAESRRVAGRTYSaarAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRAS 203
Cdd:cd15002  89 SFTIAVLAKACYMYVVNPTKQVTIKQRRIT---AVVASIWVPACLLPLPQWLFRTVKQSEGVYLCILCIPPLAHEFMSAF 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 RLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTV--VALTTDLPQ 281
Cdd:cd15002 166 VKLYPLFVFCLPLTFALFYFWRAYGQCQRRGTKTQNLRNQIRSRKLTHMLLSVVLAFTILWLPEWVAWLwlIHIKSSGSS 245
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53828924 282 TPLVIAISYFItsLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15002 246 PPQLFNVLAQL--LAFSISSVNPIIFLLMSEEFREGF 280
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
50-318 2.36e-28

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 110.64  E-value: 2.36e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLR-APRMKTVTNLFILNLAIADELFTLVLPInIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15188  13 LGLAGNLLLFVVLLLyVPKKKKMTEVYLLNLAVSDLLFLVTLPF-WAMYVAWHWVFGSFLCKFVSTLYTINFYSGIFFVS 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARL-DDEQGRRQCVLVFPQPEAFWWRASRLYT 207
Cdd:cd15188  92 CMSLDKYLEIVHAQSPHRL--RTRRKSLLVLVAVWVLSIALSVPDMVFVQThHTNNGVWVCHADYGGHHTIWKLVFQFQQ 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 LVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALErakkrvtfLVVAILAVCLLCWTPYHLSTVVALTTDLP-----QT 282
Cdd:cd15188 170 NLLGFLFPLLAMVFFYSRIACVLTRLRPPGQGRALR--------FVAALVVVFFVLWFPYNLTLFLHSLQDLHvigncER 241
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53828924 283 PLVIAISYFIT-SLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15188 242 SRHLDYALQVTeSLAFVHCCLNPLLYAFVSKRFRLYL 278
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
47-317 2.61e-28

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 110.63  E-value: 2.61e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPInIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15173  10 MFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPF-WAYSAAHEWIFGTVMCKITNGLYTINLYSSMLI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQgRRQCVLVFPQPEAfwWRASRLY 206
Cdd:cd15173  89 LTCITVDRFIVIVQATKAHNCHAKKMRWGKVVCTLVWVISLLLSLPQFIYSEVRNLS-SKICSMVYPPDAI--EVVVNII 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVLGFAIPVSTICVLYTTLLCRLhamrldSHAKALERAKK-RVTFLVVAILavcLLCWTPYHLSTVVALTTDLPQTPLV 285
Cdd:cd15173 166 QMTVGFFLPLLAMIICYSVIIKTL------LHAKGFQKHKSlKIIFVVVAVF---ILTQLPYNIMKLIRTLHIENTDSTN 236
                       250       260       270
                ....*....|....*....|....*....|...
gi 53828924 286 IAISYFIT-SLSYANSCLNPFLYAFLDASFRRN 317
Cdd:cd15173 237 FKYAILITeAIAYLHACLNPILYAFVGVKFRKN 269
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
47-315 3.78e-28

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 110.27  E-value: 3.78e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPI---NIADFLlrQWPFGELMCKLIVAIDQYNTFSS 123
Cdd:cd15380  10 ICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVFVLGLPFwaeNIRNQF--NWPFGNFLCRVISGVIKANLFIS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 124 LYFLTVMSADRYLVVLATAESRRVAGRTysAARAVSLAVWGIVTLVVLPFAVFARLD--DEQGRRQCVLVFPQPeaFWWR 201
Cdd:cd15380  88 IFLVVAISQDRYRTLVHTMTSRRQRSRR--QAQVICLLIWVFGGLLSIPTFLFRSVKhvPDLNISACILLFPHE--AWHF 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 202 ASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLstvVALTTDLPQ 281
Cdd:cd15380 164 ARRVELNIVGFLLPLAAIVFFNFHIIASLRERTEESRKRCGGLKDTKATRLILTLVLMFLVCWTPYHF---FAFLDFLFQ 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 53828924 282 TPLVIAI--SYFI-------TSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15380 241 VEVIQGCfwEEFIdlglqlaNFFAFANSCLNPVIYVFAGKLFR 283
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
47-318 5.56e-28

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 109.85  E-value: 5.56e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFlLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15175  10 ICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLTLPFWAASA-AKKWVFGEEMCKAVYCLYKMSFFSGMLL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFwWRASRLY 206
Cdd:cd15175  89 LMCISIDRYFAIVQAASAHRHRSRAVFISKVSSLGVWVLAFILSIPELLYSGVNNNDGNGTCSIFTNNKQTL-SVKIQIS 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVLGFAIPVSTICVLYTTLLCRLhamrldSHAKALERAKK-RVTFLVVAILAVCLLcwtPYH-------LSTVVALTTD 278
Cdd:cd15175 168 QMVLGFLVPLVVMSFCYSVIIKTL------LQARNFEKNKAiKVIIAVVVVFVVFQL---PYNsvmlvstLSSFKGNTTD 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 53828924 279 LpQTPLVIAISYFIT-SLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15175 239 C-DYSKNLDFALDVTySLACFRCCLNPFLYAFIGVKFRNDL 278
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
51-318 1.10e-27

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 109.07  E-value: 1.10e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  51 GLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPInIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVM 130
Cdd:cd15184  14 GFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPF-WAHYAANEWVFGNAMCKLLTGLYHIGFFSGIFFIILL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 131 SADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPE-AFWWRASRLYTLV 209
Cdd:cd15184  93 TIDRYLAIVHAVFALKA--RTVTFGVVTSVVTWVVAVFASLPGIIFTKSQKEGSHYTCSPHFPPSQyQFWKNFQTLKMNI 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 210 LGFAIPVSTICVLYTTLLCRLHAMRldshakaLERAKKRVTFLVVAILAVCLLCWTPYHLstVVALTTDLPQTPLVIAIS 289
Cdd:cd15184 171 LGLVLPLLVMIICYSGILKTLLRCR-------NEKKRHKAVRLIFTIMIVYFLFWAPYNI--VLLLNTFQEFFGLNNCSS 241
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53828924 290 Y--------FITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15184 242 SnrldqamqVTETLGMTHCCINPVIYAFVGEKFRSYL 278
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-318 1.27e-27

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 109.27  E-value: 1.27e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15125  10 IITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTcVPVDASRYFYEEWMFGTVGCKLIPVIQLTSVGVSVF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAGRTYSAARAVslAVWGIVTLVVLPFAVFARL----DDEQGRRQCVLVFPQPEAFWWR 201
Cdd:cd15125  90 TLTALSADRYKAIVNPMDIQTSSAVLRTCLKAI--AIWVVSVLLAVPEAVFSEVahimPDDNTTFTACIPYPQTDEMHPK 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 202 ASRLYTLVLGFAIPVSTICVLY----TTLLCRLHAM--RLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHlstVVAL 275
Cdd:cd15125 168 IHSVLIFLVYFLIPLAIISIYYyhiaKTLIKSAHNIpgEYSEHSKRQMETRKRLAKIVLVFVGLFAFCWFPNH---VLYM 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 53828924 276 TTDLPQTPLVIAISYFITS-----LSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15125 245 YRSFNYNEIDSSLGHMIVTlvarvLSFCNSCVNPFALYLLSESFRRHF 292
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
47-318 3.47e-27

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 107.86  E-value: 3.47e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQ-WPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15160  10 VFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWIDYTANHHnWTFGPLSCKVVGFFFYTNIYASIG 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARL-DDEQGRRQCVLVFPQPEafWWRASR 204
Cdd:cd15160  90 FLCCIAVDRYLAVVHPLRFRGL--RTRRFALKVSASIWVLELGTHSVFLGHDELfRDEPNHTLCYEKYPMEG--WQASYN 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTLVLGFAIPVSTICVLYTTLlcrLHAMRldsHAKALERA-KKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTP 283
Cdd:cd15160 166 YARFLVGFLIPLSLILFFYRRV---LRAVR---QSPSLEREeKRKIIGLLLSIVVIFLLCFLPYHVVLLVRSVIELVQNG 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 53828924 284 L------VIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15160 240 LcgfekrVFTAYQISLCLTSLNCVADPILYIFVTEDVRQDL 280
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
50-318 4.69e-27

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 109.72  E-value: 4.69e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924   50 VGLAGNSAVLYVLLrAPRMKTVTNLFILNLAIADELFTLVLPINIADfLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:PHA02638 111 LGLFGNAAIIMILF-CKKIKTITDIYIFNLAISDLIFVIDFPFIIYN-EFDQWIFGDFMCKVISASYYIGFFSNMFLITL 188
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  130 MSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPF--------AVFARLDDEQ--GRRQCVLVFPQPE--- 196
Cdd:PHA02638 189 MSIDRYFAILYPISFQKY--RTFNIGIILCIISWILSLIITSPAyfifeasnIIFSAQDSNEtiSNYQCTLIEDNEKnni 266
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  197 AFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLhamrldshaKALERAKKRVTFLVVAILAVC-LLCWTPYHLSTVVAL 275
Cdd:PHA02638 267 SFLGRILQFEINILGMFIPIIIFAFCYIKIILKL---------KQLKKSKKTKSIIIVSIIIICsLICWIPLNIVILFAT 337
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 53828924  276 TTDLPQTPLVIA--ISYFIT---------SLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:PHA02638 338 MYSFKGFNSIISehICGFIKlgyammlaeAISLTHCCINPLIYTLIGENFRMHL 391
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
48-318 5.11e-27

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 107.14  E-value: 5.11e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  48 CAVGLAGNSAVLYVLLRAPRmKTVTNLFILNLAIADELFTLVLPINIADFLLR-QWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15119  11 FVLGVPGNAIVIWVTGFKWK-KTVNTLWFLNLAIADFVFVLFLPLHITYVALDfHWPFGVWLCKINSFVAVLNMFASVLF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFArlDDEQGRRQCVLVFP--QPEAFWWRASR 204
Cdd:cd15119  90 LTVISLDRYISLAHPVWSHRY--RTLKSALILCGIVWLSAAAISGPALYFR--DTMELSINVTICFNnfHKHDGDLIVMR 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTLVL-----GFAIPVSTICVLYTTLLCRLHAMRLDSHAKalerakkrVTFLVVAILAVCLLCWTPYHLSTVVALT--T 277
Cdd:cd15119 166 HTILVWvrfffGFLFPLLTMVVCYSLLAIKVKRRTLLISSK--------FFWTISAVIVAFFVCWTPYHIFSILELSihH 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 53828924 278 DLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15119 238 SSYLHNVLRAGIPLATSLAFINSCLNPILYVLIGKKFKAHL 278
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
50-318 6.23e-27

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 107.10  E-value: 6.23e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLL-RQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15161  13 LAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHLSgNHWPFGEVPCRLAGFLFYLNMYASLYFLA 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVAGRTYsaARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQpeafwwRASR--LY 206
Cdd:cd15161  93 CISVDRFLAIVHPVKSMKIRKPLY--AHVVCGFLWVIVTVAMAPLLVSPQTVEVNNTTVCLQLYRE------KASRgaLV 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVLGFAIPVSTICVLYTTLLCRLHAM-RLDSHAKalERAKKrvtfLVVAILAVCLLCWTPYHLSTVV-----ALTTDLP 280
Cdd:cd15161 165 SLAVAFTIPFVTTVTCYLLIIRSLRTGkREEKPLK--DKAIK----MIILVLTIFLICFVPYHISRYIyilshNGAGASC 238
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53828924 281 QTPLVIAISYFITS-LSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15161 239 SSRRGLALANRITScLTCLNGALDPVMYFFVAEKFRETL 277
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
49-309 1.23e-26

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 106.03  E-value: 1.23e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  49 AVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd14975  12 AIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYFLATGTWDFGLAACKGCVYVCAVSMYASVFLIT 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCvlvFPQPEAFWWRASR-LYT 207
Cdd:cd14975  92 LMSLERFLAVSRPFVSQGW--RAKALAHKVLAIIWLLAVLLATPVIAFRHVEETVENGMC---KYRHYSDGQLVFHlLLE 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 LVLGFAIPVSTICVLYTTLLCRLHAMRLdshakaleRAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVI- 286
Cdd:cd14975 167 TVVGFAVPFTAVVLCYSCLLRRLRRRRF--------RRRRRTGRLIASVVVAFAACWLPYHVGNLLEVVSELIGGSKMAg 238
                       250       260       270
                ....*....|....*....|....*....|
gi 53828924 287 -------AISYFITSLSYANSCLNPFLYAF 309
Cdd:cd14975 239 tlgkvaeAGRPIAGALAFLSSSINPLLYAF 268
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
50-317 1.26e-26

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 106.33  E-value: 1.26e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL-VLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15195  13 ISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFfNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGMYLSSFMLV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVL----ATAESRRVagrtysaaRAVSLAVWGIVTLVVLP----FAVFARLDDEQGRRQCVLVFPQPEAFWW 200
Cdd:cd15195  93 VIALDRVFAILsplsANQARKRV--------KIMLTVAWVLSALCSIPqsfiFSVLRKMPEQPGFHQCVDFGSAPTKKQE 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 201 RASRLYTLVLGFAIPVSTICVLYTTLLCRLHAM-----------RLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHL 269
Cdd:cd15195 165 RLYYFFTMILSFVIPLIITVTCYLLILFEISKMakrardtpisnRRRSRTNSLERARMRTLRMTALIVLTFIVCWGPYYV 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 53828924 270 STVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRN 317
Cdd:cd15195 245 LGLWYWFDKESIKNLPPALSHIMFLLGYLNPCLHPIIYGVFMKEIRNW 292
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
49-316 1.37e-26

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 106.05  E-value: 1.37e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  49 AVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15121  12 ILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFFLHFLSGGGWEFGSVVCKLCHYVCGVSMYASIFLIT 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQ-CVLVFPQP--EAFWWrasrL 205
Cdd:cd15121  92 LMSMDRCLAVAKPFLSQKM--RTKRSVRALLLAIWIVAFLLSLPMPFYRTVLKKNINMKlCIPYHPSVghEAFQY----L 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLHAMRLdshakaleRAKKRVTFLVVAILAVCLLCWTPYHLSTVV----ALTTDLPQ 281
Cdd:cd15121 166 FETITGFLLPFTAIVTCYSTIGRRLRSARF--------RRKRRTNRLVVLIIATFALFWLPYHVVNLIqvagALQNQAGN 237
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53828924 282 TPLVIAISY---FITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15121 238 ASVLKAAKLarpNVTALAFLSSSVNPVLYAFAGGSLIR 275
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
49-316 1.44e-26

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 106.01  E-value: 1.44e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  49 AVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLR-QWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15968  12 LLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRdRWLFGDFMCRLVRFLFYFNLYGSILFL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLATAesRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYT 207
Cdd:cd15968  92 TCISVHRYLGICHPM--RPWHKETRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRTVCYDLAPPALFPHYVPYGMAL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 LVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKK--RVTFLVVAILAVCLLcwtPYHLSTVVAL----TTDLPQ 281
Cdd:cd15968 170 TVSGFLLPFSIILWCYCLVVRTLCRTLGPAEPPAQARRRKsiRTIVTVTLLFALCFL---PFHITRTIYLavrvTPGVPC 246
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53828924 282 TPL-VIAISYFITS-LSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15968 247 HVLeAVAACYKITRpLASANSVLNPLLYFLTKKKFGR 283
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
50-315 1.49e-26

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 105.98  E-value: 1.49e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLrQWPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15176  13 VGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFTLPFWAADAVN-GWVLGTAMCKITSALYTMNFSCGMQFLAC 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYlVVLATAESRRVAGRTysaARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRAS-RLYTL 208
Cdd:cd15176  92 ISVDRY-VAITKATSRQFTGKH---CWIVCLCVWLLAILLSIPDLVFSTVRENSDRYRCLPVFPPSLVTSAKATiQILEV 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 209 VLGFAIPVSTICVLYTTLlcrlhamrldshAKALERA---KKRVTFLV-VAILAVCLLCWTPYH-------LSTVVALTT 277
Cdd:cd15176 168 LLGFVLPFLVMVFCYSRV------------ARALSRTpnvKKSRALKVlLAVVGVFIVTQLPYNvvkfyraIDVIYLLIT 235
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53828924 278 DLpQTPLVIAISYFIT-SLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15176 236 DC-SMSKTLDIAIQVTeSIALFHSCLNPVLYVFMGASFK 273
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
50-318 2.48e-26

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 105.63  E-value: 2.48e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLlRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLL-RQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15120  13 VGLVVNGLYLWVL-GFKMRRTVNTLWFLHLILSNLIFTLILPFMAVHVLMdNHWAFGTVLCKVLNSTLSVGMFTSVFLLT 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRvaGRTYSAARAVSLAVWGIVTLVVLPFAVFARL-DDEQGRRQC---VLVFPQPEAFWWRASR 204
Cdd:cd15120  92 AISLDRYLLTLHPVWSRQ--HRTNRWASAIVLGVWISAILLSIPYLAFRETrLDEKGKTICqnnYALSTNWESAEVQASR 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYT--------LVLGFAIPVSTICVLYTTllcrlhaMRLDSHAKALERAKKRVTFLVVAILAVcLLCWTPYHLSTVVALT 276
Cdd:cd15120 170 QWIhvamfvfrFLLGFLLPFLIITFCYVR-------MALKMKERGLARSSKPFKVMFTAVVSF-FVCWLPYHLHSGLVLT 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 53828924 277 TDLPQTPLVIAISYFITSLSYaNSCLNPFLYAFLDASFRRNL 318
Cdd:cd15120 242 RGRPPSLTDITLLLTVGTTCF-NTCFTPVLYLFVGENFKKVL 282
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
47-318 4.25e-26

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 105.00  E-value: 4.25e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15123  10 IISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTcVPVDATRYIADTWLFGRIGCKLLSFIQLTSVGVSVF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAGRTYSAARAVslAVWGIVTLVVLPFAVFARL-----DDEQGRRQCVLVFPQPEAFWW 200
Cdd:cd15123  90 TLTVLSADRYRAIVKPLELQTSDAVLKTCCKAG--CVWIVSMLFAIPEAVFSDLysfrdPEKNTTFEACAPYPVSEKILQ 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 201 RASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLD------SHAKALERAKKRVTFLVVAILAVCLLCWTPYH---LST 271
Cdd:cd15123 168 EIHSLLCFLVFYIIPLSIISVYYFLIARTLYKSTFNmpaeehSHARKQIESRKRVAKTVLVLVALFAFCWLPNHilyLYR 247
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 53828924 272 VVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15123 248 SFTYHTSVDSSAFHLIATIFSRVLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
50-316 1.25e-25

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 103.68  E-value: 1.25e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQ-WPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15162  13 VGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNnWIFGEALCRLVTVAFYGNMYCSILLLT 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVAGRTYsaARAVSLAVWGIVTLVVLPFAVFARLDD--EQGRRQCVLVFPQPEAF-WWRASRL 205
Cdd:cd15162  93 CISIDRYLAIVHPMGHRRLRARRY--ALGTCLAIWLLALLVTLPLYLVKQTIFlpALDITTCHDVLPEQLLVgDWFYYFL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLHAmrldSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLV 285
Cdd:cd15162 171 SLAIVGFLIPFILTASCYVATIRTLAA----LEDENSEKKKKRAIKLAATVLAIFIICFAPSNLLLLAHYSLISSSGTGH 246
                       250       260       270
                ....*....|....*....|....*....|..
gi 53828924 286 IAISYFIT-SLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15162 247 LYFAYLLAlCLSTLNSCIDPFIYYFVSKEFRD 278
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
50-316 5.94e-25

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 102.05  E-value: 5.94e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFL-LRQWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd14979  13 VGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVgLPVELYNFWwQYPWAFGDGGCKLYYFLFEACTYATVLTI 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLATAESRRVAGRtySAARAVSLAVWGIVTLVVLPFAVFARLD--------DEQGRRQCVLVFPQpeAFW 199
Cdd:cd14979  93 VALSVERYVAICHPLKAKTLVTK--RRVKRFILAIWLVSILCAIPILFLMGIQylngplpgPVPDSAVCTLVVDR--STF 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 200 WRASRLYTLVLgFAIPVSTICVLYTTLLCRLHAMRLDSHAKAL-----------ERAKKRVTFLVVAILAVCLLCWTPYH 268
Cdd:cd14979 169 KYVFQVSTFIF-FVLPMFVISILYFRIGVKLRSMRNIKKGTRAqgtrnvelslsQQARRQVVKMLGAVVIAFFVCWLPFH 247
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 53828924 269 LSTVVALTTDLPQTPLVIA--ISYFITS-LSYANSCLNPFLYAFLDASFRR 316
Cdd:cd14979 248 AQRLMFSYASKEDTFLFDFyqYLYPISGiLFYLSSAINPILYNLMSSRFRV 298
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
47-316 6.19e-25

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 101.98  E-value: 6.19e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQ-WPFGELMCKLIVAIDQYNTFSSL 124
Cdd:cd14997  10 IFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVcMPVALVETWAREpWLLGEFMCKLVPFVELTVAHASV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAESRRVAGRTYsAARAVSLaVWGIVTLVVLPFAVFA--RLDDEQGRRQCVLVFPQPEAFWWRA 202
Cdd:cd14997  90 LTILAISFERYYAICHPLQAKYVCTKRR-ALVIIAL-IWLLALLTSSPVLFITefKEEDFNDGTPVAVCRTPADTFWKVA 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 SRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALE------RAKKRVTFLVVAILAVCLLCWTPYHLSTVVALT 276
Cdd:cd14997 168 YILSTIVVFFVVPLAILSGLYSVICRRLVGHPALESRRADAanrhtlRSRRQVVYMLITVVVLFFVCLLPFRVVTLWIIF 247
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 53828924 277 TDLPQTPL-----VIAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd14997 248 APDEDLQAlglegYLNLLVFCRVMVYLNSALNPILYNLMSTKFRS 292
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
50-318 7.32e-25

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 101.33  E-value: 7.32e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINiADFLLR--QWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15157  13 LGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFVSTLPFR-ADYYLMgsHWVFGDIACRIMSYSLYVNMYCSIYFL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLATAesRRVAGRTYSAARAVSLAVWgivTLVVLPFAVFARLDDEQGRRQCVLVFPQPEafwwRASRLYT 207
Cdd:cd15157  92 TVLSIVRFLAIVHPF--KLWKVTSIKYARILCAVIW---IFVMAASSPLLSKGTSKYNSQTKCLDLHPS----KIDKLLI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 -----LVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTflVVAILAVCLLCWTPYH-LSTVVALTTDLPQ 281
Cdd:cd15157 163 lnyivLVVGFILPFCTLSICYILIIKALLKPRVPQSKLRVSHKKALLT--IIITLILFLLCFLPYHiLRTVHLMQWSEGQ 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53828924 282 TPLVIAISYFIT-SLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15157 241 CNLRLHKAVVITlCLAAANSCLDPLLYYFAGENFKERL 278
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
47-316 9.95e-25

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 100.92  E-value: 9.95e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQ-WPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15375  10 IFIVGFPGNIIAIFVYLFKMRPWKSSTIIMLNLALTDLLYVTSLPFLIYYYINGEsWIFGEFMCKFIRFIFHFNLYGSIL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAGRTYsaARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCvLVF---PQPEAFWWRA 202
Cdd:cd15375  90 FLTCFSIFRYVVIVHPLRAFQVQKRRW--AIVACAVVWVISLAEVSPMTFLITTKEKNNRTIC-LDFtssDNLNTIWWYN 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 srLYTLVLGFAIPVSTICVLYTTLLCRLhAMRLDSHAKALERAKKrvtfLVVAILAVCLLCWTPYHLSTVVALTTDLPQT 282
Cdd:cd15375 167 --WILTVLGFLLPLVIVTLCYTRIIYTL-AKGPHTGSASKQKARR----LIILILLVFYVCFLPFHILRVVRIETRLPPV 239
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53828924 283 P-----LVIAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15375 240 ScclkhQVHAIYIITRPLAALNTFGNLLLYVVSGDNFQQ 278
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
47-318 1.35e-24

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 100.60  E-value: 1.35e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLR-QWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15373  10 VFVVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTLYVLSLPLLVYYYADEnDWPFSEALCKIVRFLFYTNLYCSIL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAGRTYsaARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVfPQPEAF-WWRASR 204
Cdd:cd15373  90 FLLCISVHRFLGVCYPVRSLRWLKVRY--ARIVSVVVWVIVLACQSPVLYFVTTSDKGGNITCHDT-SSPELFdQFVVYS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTLVLGFAIPVSTICVLYTTLLCRLhaMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALT---TDLPQ 281
Cdd:cd15373 167 SVMLVLLFCVPFVVILVCYALMVRKL--LKPSAGTSTNSRSKKKSVKMIIIVLAVFILCFLPFHVTRTLYYSfrsMDLSC 244
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53828924 282 TPL-VIAISYFITS-LSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15373 245 GTLnAINLAYKVTRpLASANSCLDPILYFLAGQSFRSNL 283
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
47-318 3.96e-24

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 99.46  E-value: 3.96e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLL-RQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd14988  10 IFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWMLEVMLdYTWLWGSFLCKFTHYFYFANMYSSIF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRvaGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQgRRQCVLVFPQpEAF--WWRAS 203
Cdd:cd14988  90 FLTCLSVDRYLTLTSSSPFWQ--QHQHRIRRALCAGIWVLSAIIPLPEVVHMQLLDGV-EPMCLFLAPF-ETYdeWALAV 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 RLYTLVLGFAIPVSTICVLYTtllcrLHAMRLDSHAKALERakkRVTFLVVAILAVCLLCWTPYHLsTVVALTTDLPQTP 283
Cdd:cd14988 166 SLLTLIIGFLIPFSIIAVFNV-----LTARYIRTAGRPESR---RHCLLIYAYILVFVVCWLPYHV-TLLLLTLHGSHIS 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 53828924 284 L---VIAISYF----ITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd14988 237 LhcnLVHFLYFfydvIDCFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
47-316 4.02e-24

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 99.80  E-value: 4.02e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd14977  10 IFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLcVPLNAYNLLTKDWLFGDVMCKLVPFIQVTSLGVTVF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAGRTYSAARAVslAVWGIVTLVVLPFAVFARLDDEQGR-----RQCVLVFPQPEA-FW 199
Cdd:cd14977  90 SLCALSIDRYRAAVNSMPMQTIGACLSTCVKLA--VIWVGSVLLAVPEAVLSTVARESSLdnsslTVCIMKPSTPFAeTY 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 200 WRASRLYTLVLGFAIPVSTICVLYTTLLCRL--HAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTT 277
Cdd:cd14977 168 PKARSWWLFGCYFCLPLAFTAVCYLLMARTLirAAKEYTRGTKKHMKQRRQLAKTVLCLVLVFAFCWLPEHISNILRATL 247
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 53828924 278 D-----LPQTPLVIAiSYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd14977 248 YnevliDTRSTLDIL-DLIGQFLSFFNSCVNPIALYLLSEPFRR 290
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
52-316 6.28e-24

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 99.19  E-value: 6.28e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL-VLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVM 130
Cdd:cd15980  15 MMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVGIfCMPTTLLDNIIAGWPFGSTVCKMSGMVQGISVSASVFTLVAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 131 SADRYLVVLATAESRrvagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWW--------RA 202
Cdd:cd15980  95 AVDRFRCIVYPFKQK----LTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEKNYRVVLGSQNKTSPVYWcredwpnqEM 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 SRLYTLVLGFAI---PVSTICVLYTTLLCRLHAMRLDSHAK-------ALERAKKRVTFLVVAILAVCLLCWTPyhLSTV 272
Cdd:cd15980 171 RKIYTTVLFANIylaPLSLIVIMYARIGITLFKTAMPHTGKhnqeqrhVVSRKKQKVIKMLLIVALLFILSWLP--LWTL 248
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 53828924 273 VALT--TDLPQTPLVIAISY---FITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15980 249 MMLSdyANLSPNQLQIINIYiypFAHWLAFFNSSVNPIIYGFFNENFRR 297
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
50-309 1.47e-23

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 97.95  E-value: 1.47e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLL--RAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15122  13 LGLPGNGFIIWSILwkMKARGRSVTCILILNLAVADGAVLLLTPFFITFLTRKTWPFGQAVCKAVYYLCCLSMYASIFII 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYT 207
Cdd:cd15122  93 GLMSLDRCLAVTRPYLAQSL--RKKALVRKILLAIWLLALLLALPAFVYRHVWKDEGMNDRICEPCHASRGHAIFHYTFE 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 LVLGFAIPVSTICVLYTTLLCRLHAMRLdshakaleRAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIA 287
Cdd:cd15122 171 TLVAFVLPFGVILFSYSVILVRLKGARF--------RRRARVEKLIAAIVVAFALLWVPYHVVNLLQVVANLAPGEVLEK 242
                       250       260
                ....*....|....*....|....*....
gi 53828924 288 ISYF-------ITSLSYANSCLNPFLYAF 309
Cdd:cd15122 243 LGGAakaaragATALAFFSSSVNPLLYVF 271
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
52-318 1.85e-23

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 97.97  E-value: 1.85e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVM 130
Cdd:cd15391  15 VGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFcMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 131 SADRYLVVLATAESRrvagRTYSAARAVSLAVWGIV----TLVVLPFAVFARLDDEQGRRQCVLVFPQPEaFWWRASRLY 206
Cdd:cd15391  95 GIDRFFAVIFPLRSR----HTKSRTKCIIASIWAISfslsSVQLFAGRTQRYGQYSEGRVLCGESWPGPD-TSRSAYTVF 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVLGFAIPVSTICVLYTTLLCRL---------HAMRLDSHAkaleRAKKRVTFLVVAILAVCLLCWTPYHLSTVVA-LT 276
Cdd:cd15391 170 VMLLTYIIPLLILTSTYGYVGFRLwnrtapgnaDKGRDDMQI----KSKRKVIKMLVFVVLMFGICWLPLHLFNLVQdFS 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 53828924 277 TDLPQTP--LVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15391 246 TVFRNMPqhTTRLIYGACHWIAMSNSFVNPIIYLFMNDSFRSIL 289
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
47-316 1.88e-23

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 97.56  E-value: 1.88e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIAdflLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15920  10 ICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLCLPFRVA---YQNTAGPLSFCKIVGAFFYLNMYASILF 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRVAGRTYSAarAVSLAVWGIVTLVVLPFaVFARLDDEQGRRQCvlvfpqpeaFWWRASRL- 205
Cdd:cd15920  87 LSLISLDRYLKIIKPLQQFKIHTVPWSS--AASGGVWLLLLACMIPF-LFESRNEGPCDNKC---------FHFRSKGLt 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 -----YTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTV------VA 274
Cdd:cd15920 155 agginLTAVVIFYILSLLFLYFYAKISHKLYKVSLGNAQQQIKKASKRAIIKTFIVLAIFIVCFVPYHIVRVpyvlaqID 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 53828924 275 LTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15920 235 VISSLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFRR 276
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
52-318 2.49e-23

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 97.50  E-value: 2.49e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMKTVTNLFILNLAIADeLFTLVLPInIADFLLR---QWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15197  15 VVGNSSVLFALWMRKAKKSRMNFFITQLAIAD-LCVGLINV-LTDIIWRitvEWRAGDFACKVIRYLQVVVTYASTYVLV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLvvlATAESRRVAgRTYSAARAVSLAVWGIVTLVVLPFAV-FARLDDEQGRRQCVLVFPQPeaFWWRASRLYT 207
Cdd:cd15197  93 ALSIDRYD---AICHPMNFS-QSGRQARVLICVAWILSALFSIPMLIiFEKTGLSNGEVQCWILWPEP--WYWKVYMTIV 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 LVLGFAIPVSTICVLYTTLL-----------------CRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLS 270
Cdd:cd15197 167 AFLVFFIPATIISICYIIIVrtiwkkskiqvtinkagLHDGSSRRSSSRGIIPRAKIKTIKMTFVIVTVFIICWSPYFVF 246
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 53828924 271 TVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15197 247 DLLDVFGLLPRSKTKIAAATFIQSLAPLNSAINPLIYCLFSTHLCRPL 294
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
47-315 6.49e-23

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 96.29  E-value: 6.49e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIAD---ELFTLVLPINIADFLlrQWPFGELMCKLIVAIDQYNTFSS 123
Cdd:cd14986  10 LFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADlvvAFFTVLTQIIWEATG--EWVAGDVLCRIVKYLQVVGLFAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 124 LYFLTVMSADRYLVVlaTAESRRVAGRTysAARAVSLAVWGIVTLVVLP-FAVFARLDDEQGRRQCVLVFPQPeafW-WR 201
Cdd:cd14986  88 TYILVSMSLDRYQAI--VKPMSSLKPRK--RARLMIVVAWVLSFLFSIPqLVIFVERELGDGVHQCWSSFYTP---WqRK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 202 ASRLYTLVLGFAIPVSTICVLYTTLLCRL-------HAMRLDSHAKA-------------LERAKKRVTFLVVAILAVCL 261
Cdd:cd14986 161 VYITWLATYVFVIPLIILSYCYGRILRTIwirsrqkTDRPIAPTAMScrsvscvssrvslISRAKIKTIKMTLVIILAFI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 53828924 262 LCWTPYHLSTVVALTTDLPQTPLVIAISYFItsLSYANSCLNPFLYAFLDASFR 315
Cdd:cd14986 241 LCWTPYFIVQLLDVYAGMQQLENDAYVVSET--LASLNSALNPLIYGFFSSHLS 292
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
54-318 6.49e-23

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 96.04  E-value: 6.49e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  54 GNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSA 132
Cdd:cd15979  17 GNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFcMPFTLIPNLMGTFIFGEVICKAVAYLMGVSVSVSTFSLVAIAI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 133 DRYLVVLATAESRrvAGRTYSAARAVSLAVWGIVTLVVLPFAVFARL-----DDEQGRRQCVLVFPQPEAfwWRASRLYT 207
Cdd:cd15979  97 ERYSAICNPLQSR--VWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTvpvpvGDRPRGHQCRHAWPSAQV--RQAWYVLL 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 LVLGFAIPVSTICVLYTTLLCRLHAMRLdshakalerAKKRVTFLVVAILAVCLLCWTP-YHLSTVVALTTDLPQTPLVI 286
Cdd:cd15979 173 LLILFFIPGVVMIVAYGLISRELYRGLL---------AKKRVIRMLVVIVAMFFLCWLPiFSANTWRAFDPLSAHRALSG 243
                       250       260       270
                ....*....|....*....|....*....|..
gi 53828924 287 AISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15979 244 APISFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
47-318 6.74e-23

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 95.99  E-value: 6.74e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15154  10 LFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYANHYWPFGNFLCQFSGSIFQMNMYGSCLF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCV-LVFpqpEAFW-WRASR 204
Cdd:cd15154  90 LMCINVDRYLAIVHPLRFRHL--RRPKVARLLCLAVWALILGGSVPAAIVHSSSDCLLHGEKVyRCF---ESFSdNDWKG 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTLV-----LGFAIPVSTIcvlyttLLCRLHAMRLDSHAKALERAKKRVT-FLVVAILAVCLLCWTPYHLSTVV----- 273
Cdd:cd15154 165 LLPLVvlaeiLGFLLPLAAV------LYCSCRIFVELCRTQEPQQGRRRKTvRLLLVNLVIFLICFVPYNTTLAVygllr 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 53828924 274 --ALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15154 239 anLVEDTWNIKDTLRKVLSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
47-317 1.54e-22

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 95.23  E-value: 1.54e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15205  10 IFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFcIPFTLLQNISSNWLGGAFMCKMVPFVQSTAVVTSIL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVagrtYSAARAVSL--AVWGIVTLVVLPFAVFARLDD------EQGRRQCVlvfpqpEA 197
Cdd:cd15205  90 TMTCIAVERHQGIVHPLKMKWQ----YTNRRAFTMlgLVWIVSVIVGSPMLFVQQLEVkydflyEKRHVCCL------ER 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 198 FWWRASR----LYTLVLGFAIPVSTICVLYTTLLCRL------------HAMRLDSHAKALeRAKKRVTFLVVAILAVCL 261
Cdd:cd15205 160 WYSPTQQkiytTFILVILFLLPLTTMLFLYSRIGYELwikkrvgdasvlQTIHGIEMSKIS-RKKKRAVKMMVTVVLLFA 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 53828924 262 LCWTPYHLSTVVALTTDLPQ------TPLVIAISYFItslSYANSCLNPFLYAFLDASFRRN 317
Cdd:cd15205 239 VCWAPFHVVHMMIEYSNLENkydgvtIKLIFAIVQLI---GFSNSFNNPIVYAFMNENFKKN 297
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
51-318 2.52e-22

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 94.44  E-value: 2.52e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  51 GLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLR-QWPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd16001  14 GLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRdRWPFGDFLCKLVRFLFYTNLYGSILFLTC 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLVVLATAESrrVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCvLVFPQPEAFwwRASRLYTLV 209
Cdd:cd16001  94 ISVHRFLGVCYPIRS--LAYRTRRLAVIGSAATWILVVLQLLPTLVYARTGSINNRTVC-YDLTSPDNF--GNYFPYGMV 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 210 L---GFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVclLCWTPYHLSTVVAL------TTDLP 280
Cdd:cd16001 169 LtvtGFLIPFLIILLCYCLMIKSLIRSEEAAGVGKAARAKSIRTILLVCGLFA--LCFVPFHITRTIYLfvrvylVQDCP 246
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53828924 281 QTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd16001 247 LLQFVSLAYKIWRPLVSFNSCINPLLYFLSGDSNRLRL 284
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-315 2.98e-22

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 94.23  E-value: 2.98e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIAD-ELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd16003  10 VVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDaSMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSVFASIY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAgrtySAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQ--PEAFWWras 203
Cdd:cd16003  90 SMTAIAVDRYMAIIDPLKPRLSA----TATKVVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVAWPGgpDQHFTY--- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 RLYTLVLGFAIPVSTICVLYTTLLCRLHAMRL--DSHAKALE--RAKKRVTFLVVAILAVCLLCWTPYHLSTVV-ALTTD 278
Cdd:cd16003 163 HIIVIVLVYCLPLLVMGITYTIVGITLWGGEIpgDTSDKYHEqlRAKRKVVKMMIIVVLTFAICWLPYHIYFIVtGLYQQ 242
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53828924 279 LPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd16003 243 LNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFR 279
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
50-318 3.18e-22

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 94.40  E-value: 3.18e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15378  13 LGFIGNTIVILGYIFCLKNWKSSNIYLFNLSVSDLAFLCTLPMLVYSYSNGQWLFGDFLCKSNRYLLHANLYSSILFLTF 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLVVLATAESRRVAGRtySAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAfwwRASRLYTL- 208
Cdd:cd15378  93 ISIDRYLLIKYPFREHILQKK--RSAVAISLAIWVLVTLELLPILTFIGPNLKDNVTKCKDYASSGDA---TNSLIYSLf 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 209 --VLGFAIPVSTICVLYTTLLCRLHAM-RLDSHAKALERAKKrvtfLVVAILAVCLLCWTPYH-------LSTVVALTTD 278
Cdd:cd15378 168 ltVTGFLIPLCVMCFFYYKIALFLKNRnRQLANATSFEKPLT----LVILAVVIFSVLFTPYHvmrnvriASRLDSIGVS 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 53828924 279 lPQTPLVIAISYFITS-LSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15378 244 -ECTLIIIKSLYIVTRpIAFLNSVINPVFYFLMGDHFREML 283
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
47-316 3.51e-22

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 94.32  E-value: 3.51e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15051  10 IILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLgLLVLPFSAIYELRGEWPLGPVFCNIYISLDVMLCTASIL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAE-SRRVAGRTYSAARAvslAVWgIVTLVVLPFAVFARLDDEQGRRQCVlvfPQPEAFWWRASR 204
Cdd:cd15051  90 NLFAISLDRYLAITAPLRyPSRVTPRRVAIALA---AIW-VVSLAVSFLPIHLGWNTPDGRVQNG---DTPNQCRFELNP 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTLVLG---FAIPVSTICVLYTTLLC--RLHAMRLDSHAKALERAKKRVTFLV---------VAILAVCLLCWTPYHls 270
Cdd:cd15051 163 PYVLLVAigtFYLPLLIMCGVYLRIFRiaREQAKRINALTPASTANSSKSAATArehkatvtlAAVLGAFIICWFPYF-- 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 53828924 271 tVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15051 241 -TYFTYRGLCGDNINETALSVVLWLGYANSALNPILYAFLNRDFRR 285
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
51-318 3.88e-22

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 94.09  E-value: 3.88e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  51 GLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVM 130
Cdd:cd15153  14 GLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQHTWPFGRFLCLLCFYLKYLNMYASICFLTCI 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 131 SADRYLVVLATAESRRVAGRtYSAarAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCV--LVFPQPEAFWWRASRLYTL 208
Cdd:cd15153  94 SIQRCFFLLHPFKARDWKRR-YDV--GISAAVWIVVGLACLPFPLLRSKSLSNNNRSCFadLGMKKLNFGAAIAMMTVAE 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 209 VLGFAIPVSTI--CVLYTTLLCRLHAMRLDSHAKaleraKKRVTFLVVAILAVCLLCWTPYHLSTVV------ALTTDLP 280
Cdd:cd15153 171 LFGFVIPLFIIawCTWKTENSLRQRNKQQQSTSE-----KQKALRMVRMCAAVFFICFAPYHINFLFylmvseSIITNCE 245
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53828924 281 QTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15153 246 VSQVILQFHPISLCLASLNCCLDPILYYFMTSEFQDQL 283
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
47-318 5.84e-22

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 93.65  E-value: 5.84e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIA-DFLLRQWPFGELMCKLIVAIDQYNTFSSL 124
Cdd:cd15394  10 VVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMcATCVPLTLAyAFEPRGWVFGRFMCYFVFLMQPVTVYVSV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYlVVLATAESRRVAGRTYSAARAvslAVWGIVTLVVLPFAVFARLDDEQGrrqcvLVFPQPEAFWWRASR 204
Cdd:cd15394  90 FTLTAIAVDRY-YVTVYPLRRRISRRTCAYIVA---AIWLLSCGLALPAAAHTYYVEFKG-----LDFSICEEFWFGQEK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 ---LY---TLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALE----RAKKRVTF-LVVAILAVCLLCWTPYHLSTVV 273
Cdd:cd15394 161 qrlAYacsTLLITYVLPLLAISLSYLRISVKLRNRVVPGSMTQSQaewdRARRRKTFrLLVVVVVAFAICWLPLHIFNVI 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 53828924 274 A-LTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15394 241 RdIDIDLIDKQYFNLIQLLCHWLAMSSACYNPFLYAWLHDSFRGEL 286
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
47-315 5.85e-22

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 93.27  E-value: 5.85e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLL-RAPRMKTvtNLFILNLAIADELFTLVLPINIA-DFLLRQWPFGELMCKLIVAIDQYNTFSSL 124
Cdd:cd15372  10 VFLVGLPANGLALWVLAtQVKRLPS--TIFLINLAVADLLLILVLPFKISyHFLGNNWPFGEGLCRVVTAFFYGNMYCSV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAESRRVAGRTYSAarAVSLAVWGIVTLVVLPFAVFARLD--DEQGRRQCVLVFPQPE-AFWWR 201
Cdd:cd15372  88 LLLMCISLDRYLAVVHPFFARTLRSRRFAL--CMCTAIWLIAAALTLPLTLQRQSYplERLNITLCHDVLPLDEqDTYLF 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 202 ASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRlDSHAKALerakkRVTFLVVAILAVCLlcwTPYHLSTVVALTTDLPQ 281
Cdd:cd15372 166 YYFACLAVLGFLLPLVVILFCYGSVLHTLLRSG-QRYGHAM-----KLTVLVLVSFVLCF---TPSNLLLLLHYSDPTLD 236
                       250       260       270
                ....*....|....*....|....*....|....*
gi 53828924 282 TPLVIAISYFIT-SLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15372 237 DGGNLYIVYMVSlAISTLNSCVDPFIYYYVSEEFR 271
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
54-316 1.81e-21

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 91.65  E-value: 1.81e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  54 GNSAVLYVLLRAPRMKTVTNLFILNLAIADELFT-LVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSA 132
Cdd:cd15061  16 GNLLVILAVATTRRLRTITNCYIVSLATADLLVGvLVLPLAIIRQLLGYWPLGSHLCDFWISLDVLLCTASILNLCCISL 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 133 DRYLVV-----LATAESRRVAGrtysaarAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCvlVFPQPEAFwwrasRLYT 207
Cdd:cd15061  96 DRYFAItyplkYRTKRSRRLAI-------TMILAVWVISLLITSPPLVGPSWHGRRGLGSC--YYTYDKGY-----RIYS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 LVLGFAIPVSTICVLYTTLLCRLHamrldshakaleraKKRVTFLVVAILAVC-LLCWTPYHLSTVVALTTDLPQTPlvi 286
Cdd:cd15061 162 SMGSFFLPLLLMLFVYLRIFRVIA--------------KERKTAKTLAIVVGCfIVCWLPFFIMYLIEPFCDCQFSE--- 224
                       250       260       270
                ....*....|....*....|....*....|
gi 53828924 287 AISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15061 225 ALSTAFTWLGYFNSVINPFIYAFYNKDFRR 254
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
54-315 2.21e-21

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 91.86  E-value: 2.21e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  54 GNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL-VLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSA 132
Cdd:cd15978  17 GNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLfCMPFTLIPNLLKDFIFGSAVCKTATYFMGISVSVSTFNLVAISL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 133 DRYLVVLATAESRrvAGRTYSAARAVSLAVWGIVTLVVLPFAVFARL-----DDEQGRRQCVLVFPQ--PEAFWWrasrL 205
Cdd:cd15978  97 ERYSAICKPLKSR--VWQTKSHALKVIAATWCLSFTIMLPYPIYSNLvpftrINNSTGNMCRLLWPNdvTQQSWY----I 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLHamrldsHAKALERAKKRVTFLVVAILAVCLLCWTP-YHLSTVVALTTDLPQTPL 284
Cdd:cd15978 171 FLLLILFLIPGIVMMTAYGLISLELY------RGIKFLMAKKRVIRMLIVIVILFFLCWTPiFSANAWRAFDTRSADRLL 244
                       250       260       270
                ....*....|....*....|....*....|.
gi 53828924 285 VIAISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15978 245 SGAPISFIHLLSYTSACVNPIIYCFMNKRFR 275
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
50-309 2.52e-21

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 91.84  E-value: 2.52e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15156  13 LGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFTLPFRIFYFVQRNWPFGDLLCKISVTLFYTNMYGSILFLTC 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPfAVFARLDDEQGRRQCVLVFPQPEAFWWRA--SR--L 205
Cdd:cd15156  93 ISVDRFLAIVYPFRSKTL--RTKRNAKIVCAAVWLTVLAGSLP-ASFFQSTNNQLNNNSETCFENFSSKTWKTylSKivI 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKAlerAKKRVTFLVVAILAVCLLCWTPYHLSTV---VALTTDLPQT 282
Cdd:cd15156 170 FIEIVGFFIPLILNVTCSTMVLKTLRRPNTLSRSKL---NKKKVLKMIFVHLFIFCFCFIPYNVNLVlysLVRTQTFKNC 246
                       250       260       270
                ....*....|....*....|....*....|
gi 53828924 283 PLVIAIS--YFIT-SLSYANSCLNPFLYAF 309
Cdd:cd15156 247 SVVAAVRtmYPITlCIAVSNCCFDPIVYYF 276
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
47-316 2.68e-21

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 91.89  E-value: 2.68e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15124  10 IILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTcAPVDASRYLADEWLFGRVGCKLIPFIQLTSVGVSVF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAGRTYSAARAVslAVWGIVTLVVLPFAVFARL---DDEQGRRQCVLVFPQPEA--FWW 200
Cdd:cd15124  90 TLTALSADRYKAIVRPMDIQASNALMKICLKAA--LIWILSMLLAIPEAVFSDLhpfYDKSTNKTFVSCAPYPHSneLHP 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 201 RASRLYTLVLGFAIPVSTICVLYTTLLCRL--HAMRL----DSHAKALERAKKRVTFLVVAILAVCLLCWTPYHlstVVA 274
Cdd:cd15124 168 KIHSMASFLIFYVIPLSIISVYYYFIAKNLirSAYNLpvegNVHVRRQIESRKRLAKTVLVFVGLFAFCWLPNH---IIY 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 53828924 275 LTTDLPQTPLVIAISYFITS-----LSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15124 245 LYRSYHYSEVDTSMLHFVSSicariLAFTNSCVNPFALYLLSKSFRK 291
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
52-318 2.70e-21

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 91.74  E-value: 2.70e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL--VLPiNIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15012  14 FFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIfcVLQ-NLSIYLIPSWPFGEVLCRMYQFVHSLSYTASIGILVV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLVVLATAESRRVAgrTYSAARAVSLAVWGIVTLVVLPFAVFARL------DDEQGRRQCVLvfpQPEAFWWRAS 203
Cdd:cd15012  93 ISVERYIAILHPLRCKQLL--TAARLRVTIVTVWLTSAVYNTPYFVFSQTveilvtQDGQEEEICVL---DREMFNSKLY 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 RLYTLVLGFAIPVSTICVLYTTLLCRLhamrldSHAKALErAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQ-- 281
Cdd:cd15012 168 DTINFIVWYLIPLLIMTVLYSKISIVL------WKSSSIE-ARRKVVRLLVAVVVSFALCNLPYHARKMWQYWSEPYRcd 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 53828924 282 ---TPLVIAISYFITslsYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15012 241 snwNALLTPLTFLVL---YFNSAVNPLLYAFLSKRFRQSM 277
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
54-316 4.93e-21

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 90.75  E-value: 4.93e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  54 GNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSA 132
Cdd:cd15321  23 GNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVaTLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCTSSIVHLCAISL 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 133 DRYLVVLATAESRrvAGRTYSAARAVSLAVWGIVTLVVLPFAVFA--RLDDEQGRRQCVLvfpqPEAFWWrasRLYTLVL 210
Cdd:cd15321 103 DRYWSVSRAIEYN--SKRTPRRIKCIILIVWLIAAVISLPPLIYKgkQKDEQGGLPQCKL----NEEAWY---ILSSSIG 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 211 GFAIPVSTICVLYttllcrlhaMRLDSHAKALErakKRVTFLVVAILAVCLLCWTPYHLS-TVVALTTDLPQTPLviAIS 289
Cdd:cd15321 174 SFFAPCLIMILVY---------LRIYLIAKNRE---KRFTFVLAVVIGVFVLCWFPFFFSySLGAICPELCKVPH--SLF 239
                       250       260
                ....*....|....*....|....*..
gi 53828924 290 YFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15321 240 QFFFWIGYCNSSLNPVIYTIFNQDFRR 266
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
50-318 5.35e-21

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 91.02  E-value: 5.35e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLR-QWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15374  13 VGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPTLIYYYADHnHWPFGVVACKIVRFLFYANLYCSILFLT 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAES-RRVAGRTysaARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYT 207
Cdd:cd15374  93 CISVHRYVGICHPIRAlRWVKPRH---AYLICASVWLVVTVCLVPNLIFVTTSRKDNITLCHDTTRPEEFDHYVHYSSAV 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 LVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQ----TP 283
Cdd:cd15374 170 MVLLFGIPCLVIVVCYGLMARRLCKPRVGSSRQQGPSSKKRSLKTIIMVLTVFAICFVPFHITRTLYYVARLLKadcdTL 249
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 53828924 284 LVIAISYFITS-LSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15374 250 NIINVTYKVTRpLASANSCLDPILYFLAGDKYRRRL 285
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
52-318 5.72e-21

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 90.38  E-value: 5.72e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVM 130
Cdd:cd15323  15 IVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVaTLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSIVHLCAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 131 SADRYLVVLATAESRrvAGRTYSAARAVSLAVWGIVTLVVLPFAV-FARLDDEQGRRQCVLvfpqPEAFWWrasRLYTLV 209
Cdd:cd15323  95 SLDRYWSVTQAVEYN--LKRTPRRVKAIIVTVWLISAVISFPPLIsMYRDPEGDVYPQCKL----NDETWY---ILSSCI 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 210 LGFAIPvstiCVLYTTLLCRLHAMrldshAKALErakKRVTFLVVAILAVCLLCWTP----YHLSTVVALTTDLPQTplv 285
Cdd:cd15323 166 GSFFAP----CLIMILVYIRIYRV-----AKARE---KRFTFVLAVVMGVFVVCWFPfffsYSLYGICREACEVPEP--- 230
                       250       260       270
                ....*....|....*....|....*....|...
gi 53828924 286 iaISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15323 231 --LFKFFFWIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
50-309 6.37e-21

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 90.63  E-value: 6.37e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRmKTVTNLFILNLAIADELFTLVLPInIADFLLR--QWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15118  13 LGIVENLLILWVVGFRLR-RTVISIWILNLALSDLLATLSLPF-FTYYLASghTWELGTTFCRIHSSIFFLNMFVSGFLL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLATAESRRvaGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQ-GRRQC----VLVFPQPEA----- 197
Cdd:cd15118  91 AAISLDRCLLVVKPVWAQN--HRNVAAAKKICGVIWAMALINTIPYFVFRDVIERKdGRKLCyynfALFSPSPDNnhpic 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 198 -FWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRldshakalERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALT 276
Cdd:cd15118 169 kQRQEGLAISKLLLAFLIPLVIIAVSYAVVSLIIRHRC--------RRRPGRFVRLVVSVVVSFALCWAPYHIFSIIEVM 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 53828924 277 TDLPQT--PLVIAISYFITSLSYANSCLNPFLYAF 309
Cdd:cd15118 241 AHNQHSlrPLVIQGLPFATTLAFLNSVLNPVLYVF 275
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
50-316 6.45e-21

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 90.91  E-value: 6.45e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15208  13 VGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIIcLPATLLVDVTETWFFGQVLCKIIPYLQTVSVSVSVLTLS 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVAGRtysaARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRAS----- 203
Cdd:cd15208  93 CIALDRWYAICHPLMFKSTAKR----ARVSILIIWIVSLLIMIPQAIVMECSRVVPLANKTILLTVCDERWSDSIyqkvy 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 RLYTLVLGFAIPVSTICVLYT----TLLCR------------LHAMRLDSHAKALE--RAKKRVTFLVVAILAVCLLCWT 265
Cdd:cd15208 169 HICFFLVTYLLPLCLMILAYFqifrKLWCRqipgtssvvqrkWNKPRKSAVAAEEKqlRSRRKTAKMLIVVVIMFAICYL 248
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 53828924 266 PYHLSTVVALTTDLPQTPLVIAISYFITS--LSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15208 249 PVHLLNILRYVFGLFTVDRETIYAWFLFShwLVYANSAINPIIYNFMSGKFRE 301
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-315 7.65e-21

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 90.74  E-value: 7.65e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15977  10 IFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYILIaIPINVIKLIAEDWPFGVHVCKLYPFIQKASVGITVL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYlvvLATAESRRVAGRTYSAARAVSLAV-WGIVTLVVLPFAVFARLDD----EQGRRQCVLVFPQPEAF-- 198
Cdd:cd15977  90 SLCALSIDRY---RAVASWSRIRGIGIPVWKAVEVTLiWAVAIIVAVPEAIAFDMVEidyrGQTLLVCMLPMEQTSSFmr 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 199 WWRASRLYTLV-LGFAIPVSTICVLYTTLLCRLHAMR------LDSHAKALERAKKRVtFLVVAILAvclLCWTPYHLST 271
Cdd:cd15977 167 FYQDVKDWWLFgFYFCLPLACTGVFYTLMSCEMLSIKngmriaLNDHMKQRREVAKTV-FCLVVIFA---LCWLPLHLSR 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 53828924 272 VVALTTDLPQTP-------LVIAISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15977 243 ILKKTIYDVKDPqrcellsFLLVMDYTGINMASLNSCINPVALYFVSRKFK 293
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
50-308 1.06e-20

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 90.33  E-value: 1.06e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15079  13 VSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNSFYEGWALGPLGCQIYAFLGSLSGIGSIWTNAA 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLVVlataeSRRVAGR--TYSAARAVSLAVWgivtLVVLPFAVFArLDDEQGRRqcvlvfpQPEAF--------- 198
Cdd:cd15079  93 IAYDRYNVI-----VKPLNGNplTRGKALLLILFIW----LYALPWALLP-LLFGWGRY-------VPEGFltscsfdyl 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 199 ---WWraSRLYTLVLGFA---IPVSTICVLYTTLLCrlhAMRldSHAKAL-ERAKK-------------------RVTFL 252
Cdd:cd15079 156 trdWN--TRSFVATIFVFayvIPLIIIIYCYSFIVK---AVF--AHEKALrEQAKKmnvvslrsnadankqsaeiRIAKV 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 53828924 253 VVAILAVCLLCWTPYHLSTVVALTTDLPQ-TPLVIAISYFitsLSYANSCLNPFLYA 308
Cdd:cd15079 229 ALTNVFLWFIAWTPYAVVALIGAFGNQSLlTPLVSMIPAL---FAKTAACYNPIVYA 282
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
53-316 1.11e-20

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 89.71  E-value: 1.11e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  53 AGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMS 131
Cdd:cd15059  16 VGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVgLLIMPFSLVNELMGYWYFGSVWCEIWLALDVLFCTASIVNLCAIS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 132 ADRYLVVlaTAESRRVAGRTYSAARAVSLAVWGIVTLVVLP--FAVFARLDDEQGRRQCVLvfpqPEAFWWrasRLYTLV 209
Cdd:cd15059  96 LDRYWSV--TQAVEYNLKRTPRRAKAMIAAVWIISAVISLPplFGWKDEQPWHGAEPQCEL----SDDPGY---VLFSSI 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 210 LGFAIPvstiCVLYTTLLCRLHamrldSHAKALERakkRVTFLVVAILAVCLLCWTPYHLS-TVVALTTDLPQTPLVIAI 288
Cdd:cd15059 167 GSFYIP----LLIMIIVYARIY-----RAAKRKER---RFTLVLGVVMGAFVLCWLPFFFTyPLVVVCKTCGVPELLFKF 234
                       250       260
                ....*....|....*....|....*...
gi 53828924 289 SYFitsLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15059 235 FFW---LGYCNSALNPVIYTIFNKDFRR 259
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
47-316 1.16e-20

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 89.41  E-value: 1.16e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15050  10 ISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVgAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVlaTAESRRVAGRTYSAARAVSLAVWGIVTLVVLP---FAVFARlDDEQGRR--QCVLVFPQPEAFww 200
Cdd:cd15050  90 SLFILCIDRYRSV--QQPLKYLKYRTKTRASLMISGAWLLSFLWVIPilgWHHFAR-GGERVVLedKCETDFHDVTWF-- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 201 rasRLYTLVLGFAIPVSTICVLYTTLLcrlhamrldshaKALERAKKRVTFLVVaILAVCLLCWTPYHLS-TVVALTTDL 279
Cdd:cd15050 165 ---KVLTAILNFYIPSLLMLWFYAKIF------------KAVNRERKAAKQLGF-IMAAFILCWIPYFILfMVIAFCKNC 228
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53828924 280 PQTPLviaiSYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15050 229 CNENL----HMFTIWLGYINSTLNPFIYPLCNENFKK 261
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
50-316 1.29e-20

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 89.77  E-value: 1.29e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVL-LRAPRMKTVTNLfILNLAIADELFTLVLPINIADFLL-RQWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15922  13 GGFLLNSFSLWIFwFRIKQWSSGTIL-QFNLALSDAIITPAAPLLIAYFSLgSHWPFGQFLCQLKVFLLSTHMYGSIYFL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLATaeSRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYT 207
Cdd:cd15922  92 MLISIHRYVTVVHY--NWKSLWKKKSFMKKLCLGVWLLLFVQGLPFFFVLKTSVIDGKTKCLSIHQSELSLLYFVWNFVL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 LVLGFAIPVSTICVLYTTLLCRLHAMRLDShAKALErAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDL----PQTP 283
Cdd:cd15922 170 LILGFLLPFGVSLTCYALLGASIAKMNSNN-ARGRA-MKAKSLQMIGISLVIFIICFVPLHVTRTVGVVVKLfypeSCTL 247
                       250       260       270
                ....*....|....*....|....*....|....*
gi 53828924 284 LV-IAISYFIT-SLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15922 248 LHkVEVAYYISwVLTGVNCCLDPLLYCFASEKFRK 282
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
47-316 1.71e-20

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 88.86  E-value: 1.71e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15210  10 FMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFcAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVSLL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFAR------------LDDEQGrrqcvlvfp 193
Cdd:cd15210  90 TLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLGIWGRfgldpkvcscsiLRDKKG--------- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 194 qpeafwwRASRLYTLVLGFAIPVSTICVLYTTllcrlhamrldshakaleRAKKRVTFLVVAILAVCLLCWTPYhlsTVV 273
Cdd:cd15210 161 -------RSPKTFLFVFGFVLPCLVIIICYAR------------------REDRRLTRMMLVIFLCFLVCYLPI---TLV 212
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 53828924 274 ALTTDLPQTPLVIAISYFitsLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15210 213 NVFDDEVAPPVLHIIAYV---LIWLSSCINPIIYVAMNRQYRQ 252
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
50-318 2.71e-20

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 88.93  E-value: 2.71e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15083  13 IGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILnCPLMVISSFSGRWIFGKTGCDMYGFSGGLFGIMSINTLA 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVagRTYSAARAVSLAVW-GIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAfwwrASRLYT 207
Cdd:cd15083  93 AIAVDRYLVITRPMKASVR--ISHRRALIVIAVVWlYSLLWVLPPLFGWSRYVLEGLLTSCSFDYLSRDD----ANRSYV 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 LVL---GFAIPVSTICVLY---------TTLLCRLHAMRLDSHAKALERAKKRVTF----LVVAILAVCLLCWTPYHLST 271
Cdd:cd15083 167 ICLlifGFVLPLLIIIYCYsfifravrrHEKAMKEMAKRFSKSELSSPKARRQAEVktakIALLLVLLFCLAWTPYAVVA 246
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 53828924 272 VVALTTDLPQ-TPLVIAISYFITSLSyanSCLNPFLYAFLDASFRRNL 318
Cdd:cd15083 247 LIGQFGYLEVlTPLATAIPAAFAKTS---AIYNPVIYAFSHPKFRRAL 291
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
53-316 5.81e-20

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 87.38  E-value: 5.81e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  53 AGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMS 131
Cdd:cd15049  16 GGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVsMNLYTVYLVMGYWPLGPLLCDLWLALDYVASNASVMNLLLIS 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 132 ADRYLVVLATAESRrvAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDdeQGRR-----QCVLVFPQPEAFwwrasRLY 206
Cdd:cd15049  96 FDRYFSVTRPLTYR--AKRTPKRAILMIALAWVISFVLWAPAILGWQYF--VGERtvpdgQCYIQFLDDPAI-----TFG 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVLGFAIPVSTICVLYttllCRLHAMrldshakalERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVI 286
Cdd:cd15049 167 TAIAAFYLPVLVMTILY----WRIYRE---------TARERKAARTLSAILLAFIITWTPYNILVLVSTFCAKCIPDTLW 233
                       250       260       270
                ....*....|....*....|....*....|
gi 53828924 287 AISYFitsLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15049 234 SFGYW---LCYINSTINPFCYALCNKTFRK 260
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
52-316 6.55e-20

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 88.26  E-value: 6.55e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMK-TVTNLFILNLAIADELFT-LVLPINIADFLLRQWPFGELmCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15057  15 LLGNALVIAAVLRFRHLRsKVTNYFIVSLAVSDLLVAiLVMPWAAVNEVAGYWPFGSF-CDVWVSFDIMCSTASILNLCV 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLVVlaTAESRRVAGRTYSAARAVSLAVWGIVTLV-VLPFAVFARLDDEQGRRQCVLVFPQPEAFwwRASRLYTL 208
Cdd:cd15057  94 ISVDRYWAI--SSPFRYERRMTRRRAFIMIAVAWTLSALIsFIPVQLGWHRADDTSEALALYADPCQCDS--SLNRTYAI 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 209 V---LGFAIPVSTICVLYTTL--LCRLHAMRL-------------DSHAKALERAKKRVTFLVVAILAVCLLCWTPYH-L 269
Cdd:cd15057 170 SsslISFYIPVAIMIVTYTRIyrIARRQIRRIaaleraaqestnpDSSLRSSLRRETKALKTLSIIMGVFVCCWLPFFiL 249
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 53828924 270 STVVALTTDLPQTPLVIAISYFI--TSLSYANSCLNPFLYAFlDASFRR 316
Cdd:cd15057 250 NCVLPFCDLRTAQFPCVPDTTFIvfVWLGWANSSLNPIIYAF-NADFRK 297
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
49-318 9.47e-20

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 87.49  E-value: 9.47e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  49 AVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15397  12 AVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVCLVcLPFTVVYTLMDYWIFGEVLCKMTPFIQCMSVTVSILSL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLATAESRRVAGRTYSAAravsLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAF-----W-WR 201
Cdd:cd15397  92 VLIALERHQLIINPTGWKPSVSQAYLAV----VVIWMLACFISLPFLAFHILTDEPYKNLSHFFAPLADKAvctesWpSE 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 202 ASRL-YT---LVLGFAIPVSTICVLYTTLLCRLHAMR--LDSHAKALERAK--KRVTFLVVAILAVCLLCWTPYHLSTVV 273
Cdd:cd15397 168 HHKLaYTtwlLLFQYCLPLLFILVCYLRIYLRLRRRKdmLERRGEYNRRAGhsKRINVMLVSLVAAFALCWLPLNVFNAI 247
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 53828924 274 AlttDLPQTPLVIAISYFITSLSY----ANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15397 248 A---DWNHEAIPHCQHNLIFSLCHlaamASTCVNPIIYGFLNSNFKKEV 293
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
50-318 9.79e-20

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 87.28  E-value: 9.79e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15155  13 LGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIFYNFNRHWPFGDSLCKISGTAFLTNIYGSMLFLTC 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEafwWRAS----RL 205
Cdd:cd15155  93 ISVDRFLAIVYPFRSRTI--RTRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTTCFEGFSKSI---WKTYlskiTI 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPvsticvLYTTLLCR---LHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYH-LSTVVALTTDLPQ 281
Cdd:cd15155 168 FIEVVGFIIP------LLLNLTCSslvLRTLRKPATLSQIGTNKEKVLKMILVHVAIFVVCFVPYNsILFLYALVRSQAI 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 53828924 282 TPLVIA----ISYFIT-SLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15155 242 ANCGVErfarTMYPITlCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
47-318 1.05e-19

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 87.27  E-value: 1.05e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLR-QWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15377  10 VFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKtDWIFGDAMCKLQRFIFHVNLYGSIL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESrrvAGR-TYSAARAVSLAVWGIVTLVVLPFAVFARLDDEqgRRQCVLVFPQPEAFWWRASR 204
Cdd:cd15377  90 FLTCISVHRYTGVVHPLKS---LGRlKKKNAICISVLVWLIVVVAISPILFYSGTGVR--KNKTITCYDTTSDEYLRSYF 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTL---VLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLP- 280
Cdd:cd15377 165 IYSMcttVAMFCVPFILILGCYGLIVRALIYKDMKYTEENNAPLRRKSIYLVIIVLTVFAVSYLPFHVMKTLNLRARLDf 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 53828924 281 QTPLVIAI------SYFIT-SLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15377 245 QTPAMCAFndrvyaTYQVTrGLASLNSCVDPILYFLAGDTFRRRL 289
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
50-311 1.80e-19

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 86.67  E-value: 1.80e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLL-RQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15967  13 VGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLYLLTLPFLVVYYLKgRKWIFGQVFCKITRFCFNLNLYGSIGFLT 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYlvvLATAESRRVAGR---TYSAarAVSLAVWGIVTLVVLPFAVFARLDDeqGRRQCvlvFPQPEAFWWRASRL 205
Cdd:cd15967  93 CISVYRY---LAIVHPMRVMGRittTHSV--VISALVWLLVVIQSLPDLFFSKTNS--NGTKC---FDTTFNDYLESYLT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVL---GFAIPVSTICVLY---TTLLCRLHAMRldshaKALERAKKRVTFLVVAILAVcllCWTPYH-------LSTV 272
Cdd:cd15967 163 YSLGWtvtGFVIPLLIILGCYghvVVVLCRNNNVD-----KGLKQRCLKLVIILIVLFSV---CYIPYHvfrnlnlLSRI 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 53828924 273 VALTTDLPQTPLVIAISYFIT-SLSYANSCLNPFLYAFLD 311
Cdd:cd15967 235 LQKQGSCTQWFRGIYIAHQVSrGLVCLNSALNPLVYLMGS 274
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
70-316 2.21e-19

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 86.45  E-value: 2.21e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  70 TVTNLFILNLAIADELFTL-VLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVV-----LATAE 143
Cdd:cd15055  33 TPTNLLLLSLAVADFLVGLlVMPFSMIRSIETCWYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVcdpllYPTKI 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 144 SRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGrrQCVLVFpqpeAFWWRASrlyTLVLGFAIPVSTICVLY 223
Cdd:cd15055 113 TIRRVKICICLCWFVSALYSSVLLYDNLNQPGLIRYNSCYG--ECVVVV----NFIWGVV---DLVLTFILPCTVMIVLY 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 224 TT--LLCRLHAMRLDSHAKALERAKKRVTFLVV----------AILAVCLLCWTPYHLSTVVALTTDLPQTplviaISYF 291
Cdd:cd15055 184 MRifVVARSQARAIRSHTAQVSLEGSSKKVSKKserkaaktlgIVVGVFLLCWLPYYIVSLVDPYISTPSS-----VFDV 258
                       250       260
                ....*....|....*....|....*
gi 53828924 292 ITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15055 259 LIWLGYFNSCLNPLIYALFYPWFRK 283
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
50-318 2.52e-19

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 86.00  E-value: 2.52e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIA-DFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15370  13 VGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFVIWFPLKIAyHINGNNWIYGEALCKVLIGFFYGNMYCSILFMT 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRvagRTYSAARAVSLAVWGIVTLVVLPFAVFAR--LDDEQGRRQCVLVFPQPEAFWWRASRLY 206
Cdd:cd15370  93 CLSVQRYWVIVNPMSHSR---KKANIAIGISLAIWLLILLVTIPLYLVKQtvFIPALDITTCHDVLPEQLLVGDMFNYFL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVLG-FAIPVSTICVLYTTLLCRLHAMRLDshaKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLV 285
Cdd:cd15370 170 SLAIGvFLFPAFLTAVAYVLMIRALKSSIND---ESIEKKRKRAIKLIVTVLVMYLICFTPSNLLLVVHYFLLKNQGQSS 246
                       250       260       270
                ....*....|....*....|....*....|....
gi 53828924 286 IAISYFIT-SLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15370 247 VYAFYITAlCLSTLNSCIDPFVYYFVSHDFRDHV 280
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
50-318 3.84e-19

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 85.83  E-value: 3.84e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTV-TNLFILNLAIADELFT-LVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15382  13 IAAVGNLTVLLILLRNRRRKRSrVNILLMHLAIADLLVTfIMMPLEIGWAATVAWLAGDFLCRLMLFFRAFGLYLSSFVL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLATAESRRvAGRTYSAARAVSlavWGIVTLVVLPFAVFARLDDE---QGRRQCVL--VFPQPEAFWwrA 202
Cdd:cd15382  93 VCISLDRYFAILKPLRLSD-ARRRGRIMLAVA---WVISFLCSIPQSFIFHVESHpcvTWFSQCVTfnFFPSHDHEL--A 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 SRLYTLVLGFAIPVSTICVLYTTLLCRL----HAMRLDSHAKA------------LERAKKRVTFLVVAILAVCLLCWTP 266
Cdd:cd15382 167 YNIFNMITMYALPLIIIVFCYSLILCEIsrksKEKKEDVSEKSssvrlrrssvglLERARSRTLKMTIVIVLVFIICWTP 246
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 53828924 267 YHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15382 247 YFIMSLWYWFDRESASKVDPRIQKGLFLFAVSNSCMNPIVYGYFSIDLRREL 298
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
51-316 4.26e-19

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 85.85  E-value: 4.26e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  51 GLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQ-WPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15134  14 GVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILgLPFELYTIWQQYpWVFGEVFCKLRAFLSEMSSYASVLTIT 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVAgrtySAARAVSL--AVWGIVTLVVLPFA-----VFARLDDEQGRRQ-----C-VLVFPQP 195
Cdd:cd15134  94 AFSVERYLAICHPLRSHTMS----KLSRAIRIiiAIWIIAFVCALPFAiqtriVYLEYPPTSGEALeesafCaMLNEIPP 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 196 EAFWWRASrlyTLVLgFAIPVSTICVLYTTLLCRLHAMRL------DSHAKALE-RAKKRVTFLVVAILAVCLLCWTPYH 268
Cdd:cd15134 170 ITPVFQLS---TFLF-FIIPMIAIIVLYVLIGLQLRRSTLlrrgqrSVSGGRRSsQSRRTVLRMLVAVVVAFFICWAPFH 245
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 53828924 269 LSTVVALTTDLPQTPLVIAIS--YFITS-LSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15134 246 AQRLLTVYAKNMTPPYLFINRilFYISGvLYYVSSTVNPILYNVMSAKYRQ 296
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
47-315 5.24e-19

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 85.26  E-value: 5.24e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15399  10 IILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVnTLCLPFTLVYTLLDEWKFGAVLCHLVPYAQALAVHVSTV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAGRTYSaarAVSLAvWGIVTLVVLPFAVFARLDDEQ-----GRRQCVLVFPQPEAFWW 200
Cdd:cd15399  90 TLTVIALDRHRCIVYHLESKISKKISFL---IIGLT-WAASALLASPLAIFREYSVIEispdfKIQACSEKWPNGTLNDG 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 201 RASRLYTLVLGFAIPVSTICVLYTTLLCRLH------AMRLDSHAKaleraKKRVTFLVVAILAVCLLCWTPYHL----S 270
Cdd:cd15399 166 TIYSVSMLLIQYVLPLAIISYAYIRIWTKLKnhvspgGGNDHYHQR-----RRKTTKMLVCVVVVFAVSWLPFHAfqlaS 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 53828924 271 TVVALTTDLPQTPLVIAISYFITSLSyanSCLNPFLYAFLDASFR 315
Cdd:cd15399 241 DIDSKVLDLKEYKLIYTIFHVIAMCS---TFANPLLYGWMNNNYR 282
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
48-318 6.46e-19

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 85.19  E-value: 6.46e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  48 CAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQ-WPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd14991  11 FVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFRIDYYLRGEhWIFGEAWCRVNLFMLSVNRSASIAF 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATaeSRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQC--VLVFPQPEA--FWWRA 202
Cdd:cd14991  91 LTAVALDRYFKVVHP--HHRVNRMSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVNSNKSSChsFSSYTKPSLsiRWHNA 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 SRLYTLVLGFAIPVSTICVLYTTLLCRLhamRLDSHAKaLERAkKRVTFLVVAILAVCLL-CWTPYHLSTVVALTTDLPQ 281
Cdd:cd14991 169 LFLLEFFLPLGLIVFCSVRIACNLRIRQ---SLGKQAR-VQRA-IRLVFLVVIVFVLCFLpSIIAGLLALVFKNLGSCRC 243
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53828924 282 TPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd14991 244 LNSVAQLFHISLAFTYLNSALDPVIYCFSSPWFRNSL 280
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
54-317 6.79e-19

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 85.05  E-value: 6.79e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  54 GNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSA 132
Cdd:cd15048  17 GNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVsMPFYIPYTLTGKWPFGKVFCKAWLVVDYTLCTASALTIVLISL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 133 DRYL-VVLATAESRRVAGRtysaaRAVSL--AVWGIVTLVVLPFAVF-----ARLDDEQGRrqCVLVFPQPEAFWWRASr 204
Cdd:cd15048  97 DRYLsVTKAVKYRAKQTKR-----RTVLLmaLVWILAFLLYGPAIIGwdlwtGYSIVPTGD--CEVEFFDHFYFTFITS- 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 lytlVLGFAIPVSTICVLYTTLLC---------RLHAMRLDSHAKALERAKKRVTFL----------VVAILAVC-LLCW 264
Cdd:cd15048 169 ----VLEFFIPFISVSFFNLLIYLnirkrsrrrPLRSVPILPASQNPSRARSQREQVklrrdrkaakSLAILVLVfLICW 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 53828924 265 TPYHLSTVValtTDLPQTPLVIAISY-FITSLSYANSCLNPFLYAFLDASFRRN 317
Cdd:cd15048 245 APYTILTII---RSFCSGSCVDSYLYeFTFWLLWTNSAINPFLYAACHPRFRKA 295
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
50-315 6.98e-19

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 85.29  E-value: 6.98e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15976  13 LGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIIIdIPINVYKLLAEDWPFGVEMCKLVPFIQKASVGITVLSLC 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYlvvLATAESRRVAGRTYSAARAVSLA-VWGIVTLVVLPFAVFARL--DDEQGR--RQCVLVFPQPEA---FWW 200
Cdd:cd15976  93 ALSIDRY---RAVASWSRIKGIGVPKWTAVEIVlIWVVSIILAVPEAIGFDMitMDYKGEllRICLLHPIQKTAfmqFYK 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 201 RASRLYTLVLGFAIPVSTICVLYTTLLCRL------HAMRLDSHAKALERAKKRVTFLVVailaVCLLCWTPYHLSTVVA 274
Cdd:cd15976 170 TAKDWWLFSFYFCLPLACTAVFYTLMTCEMlrkkngMQIALNDHLKQRREVAKTVFCLVL----VFALCWLPLHLSRILK 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 53828924 275 LTTDLPQTP-------LVIAISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15976 246 LTIYDEKDPnrcellsFFLVLDYIGINMASLNSCINPIALYLVSKRFK 293
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
47-316 9.40e-19

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 84.99  E-value: 9.40e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRaPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQwpFGELMCKLIVAIDQY-----NT 120
Cdd:cd14978  10 ICIFGIIGNILNLVVLTR-KSMRSSTNVYLAALAVSDILVlLSALPLFLLPYIADY--SSSFLSYFYAYFLPYiyplaNT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 121 F--SSLYFLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFA------VFARLDDEQGRRQCVLVF 192
Cdd:cd14978  87 FqtASVWLTVALTVERYIAVCHPLKARTW--CTPRRARRVILIIIIFSLLLNLPRFfeyevvECENCNNNSYYYVIPTLL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 193 PQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLH----AMRLDSHAKALERAKK----RVTFLVVAILAVCLLCW 264
Cdd:cd14978 165 RQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRkskkRRRLLRRRRRLLSRSQrrerRTTIMLIAVVIVFLICN 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 53828924 265 TPYHLSTVV-ALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd14978 245 LPAGILNILeAIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRR 297
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
50-315 1.12e-18

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 84.55  E-value: 1.12e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFL-LRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15131  13 VGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRLWqYRPWNFGDLLCKLFQFVSESCTYSTILNIT 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVAgrTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTL 208
Cdd:cd15131  93 ALSVERYFAICFPLRAKVVV--TKRRVKLVILVLWAVSFLSAGPIFVLVGVEHENGTNPIDTNECKATEYAVRSGLLTIM 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 209 VLG----FAIPVSTICVLYTTLLCRLHAMRLDSHAKAL----ERAKKRVTFLVVAILAVcLLCWTPYHLSTVVALTTDLP 280
Cdd:cd15131 171 VWVssvfFFLPVFCLTVLYSLIGRKLWRRRRENIGPNAshrdKNNRQTVKMLAVVVFAF-VLCWLPFHVGRYLFSKSFEA 249
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53828924 281 QTPLVIAISYFITSLS----YANSCLNPFLYAFLDASFR 315
Cdd:cd15131 250 GSLEIALISQYCNLVSfvlfYLSAAINPILYNIMSKKYR 288
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
49-316 1.61e-18

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 84.16  E-value: 1.61e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  49 AVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQ-WPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15379  12 LLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLLIYNYTQKDyWPFGDFTCRLVRFQFYTNLHGSILFL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVV---LATAESRRvaGRtySAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASR 204
Cdd:cd15379  92 TCISVQRYLGIchpLASWHKKK--GK--KLTWLVCGAVWLVVIAQCLPTFVFASTGTQRNRTVCYDLSPPARSTAYFPYG 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTLVLGFAIPVSTICVLY---TTLLCRLHAMRLDSHAKALERAKKRVTFLVVAilAVCLLCWTPYHLSTVVAL----TT 277
Cdd:cd15379 168 ITLTRTGFLLPFAARLACYcsmATILCRVVIAVAVVAAPGEKRGKAARMIIVVA--AVFLISFLPFHYTKTRYLqvrsWD 245
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 53828924 278 DLPQTPL-VIAISYFIT-SLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15379 246 GGPCTTRqAFAEAYKRTrPFASMNSVLDPILFYFTQSKFRP 286
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
51-325 1.87e-18

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 84.57  E-value: 1.87e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924   51 GLAGNSAVLYVLLrAPRMKTVTNLFILNLAIADELFTLVLPINIADFLlRQWPFGELMCKLIVAIDQYNTFSSLYFLTVM 130
Cdd:PHA02834  42 GLIGNVLVIAVLI-VKRFMFVVDVYLFNIAMSDLMLVFSFPFIIHNDL-NEWIFGEFMCKLVLGVYFVGFFSNMFFVTLI 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  131 SADRYLVVLataESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVL 210
Cdd:PHA02834 120 SIDRYILVV---NATKIKNKSISLSVLLSVAAWVCSVILSMPAMVLYYVDNTDNLKQCIFNDYHENFSWSAFFNFEINIF 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  211 GFAIPVSTICVLYTTLLCRLHAMRldshakalERAKKRVTFLVVAILAVCLLCWTPYHlstVVALTTDLPQTPLV----- 285
Cdd:PHA02834 197 GIVIPLIILIYCYSKILYTLKNCK--------NKNKTRSIKIILTVVTFTVVFWVPFN---IVLFINSLQSVGLIdigcy 265
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 53828924  286 ----IAISYFITSL-SYANSCLNPFLYAFLDASFRRNLRQLItCR 325
Cdd:PHA02834 266 hfkkIVYSIDIAELiSFVHCCVNPIIYAFVGKNFKKVFKNMF-CR 309
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
47-322 2.06e-18

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 83.44  E-value: 2.06e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL--VLPINIADFLLRqwpF--GELMCKLIVAIDQYNTFS 122
Cdd:cd15196  10 ILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALfnVLPQLIWDITYR---FygGDLLCRLVKYLQVVGMYA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 123 SLYFLTVMSADRYLvvlatAESRRVAGRTYSAARA--VSLAVWGIVTLVVLP-FAVFARLDDEQGRRQCVLVFPQPeafw 199
Cdd:cd15196  87 SSYVLVATAIDRYI-----AICHPLSSHRWTSRRVhlMVAIAWVLSLLLSIPqLFIFSYQEVGSGVYDCWATFEPP---- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 200 W--RASRLYTLVLGFAIPVSTICVLYtTLLCRlhamrldshakALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTT 277
Cdd:cd15196 158 WglRAYITWFTVAVFVVPLIILAFCY-GRICY-----------VVWRAKIKTVKLTLVVVACYIVCWTPFFVVQMWAAWD 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 53828924 278 dlPQTPLVIAISYFITSLSYANSCLNPFLYAFldasFRRNLRQLI 322
Cdd:cd15196 226 --PTAPIEGPAFVIIMLLASLNSCTNPWIYLA----FSGNLRRAL 264
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
52-316 3.37e-18

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 82.78  E-value: 3.37e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINI-ADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15053  15 VFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVaILVMPFAVyVEVNGGKWYLGPILCDIYIAMDVMCSTASIFNLCA 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYlvvlaTAESRRVAGRTYSAARAVSL---AVWGIVTLVVLPfaVFARLDDEQGRRQCVLVFPQPEAFwwrasrLY 206
Cdd:cd15053  95 ISIDRY-----IAVTQPIKYARQKNSKRVLLtiaIVWVVSAAIACP--LLFGLNNVPYRDPEECRFYNPDFI------IY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVLGFAIPVSTICVLYTTLLcrlhamrldshaKALERAKKRVTFLVVaILAVCLLCWTPY---HLSTVVALTTDLPQTP 283
Cdd:cd15053 162 SSISSFYIPCIVMLLLYYRIF------------RALRREKKATKTLAI-VLGVFLFCWLPFftlNILNAICPKLQNQSCH 228
                       250       260       270
                ....*....|....*....|....*....|...
gi 53828924 284 LVIAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15053 229 VGPALFSLTTWLGYVNSFLNPIIYTIFNIEFRK 261
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
47-316 6.60e-18

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 82.02  E-value: 6.60e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQ-WPFGELMCKLIVAIDQYNTFSSL 124
Cdd:cd15067   9 FCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVgSIVMPFSILHEMTGGyWLFGRDWCDVWHSFDVLASTASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVL--ATAESRRVAGRTYSAAravsLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFwwra 202
Cdd:cd15067  89 LNLCVISLDRYWAITdpISYPSRMTKRRALIMI----ALVWICSALISFPAIAWWRAVDPGPSPPNQCLFTDDSGY---- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 sRLYTLVLGFAIPVSTICVLYttllCRLHamrldshaKALERAKKRVTFLVVaILAVCLLCWTPYH-LSTVVALTTDLPQ 281
Cdd:cd15067 161 -LIFSSCVSFYIPLVVMLFTY----YRIY--------RAAAKEQKAAKTLGI-VMGVFILCWLPFFvTNILIGFCPSNCV 226
                       250       260       270
                ....*....|....*....|....*....|....*
gi 53828924 282 TPLVIAISyFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15067 227 SNPDILFP-LVTWLGYINSGMNPIIYACSSRDFRR 260
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
50-318 6.87e-18

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 82.17  E-value: 6.87e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15395  13 LGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMcLPFTFVYTLMDHWVFGEAMCKLNSMVQCISITVSIFSLV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVAGRTYsaaraVSLAV-WGIVTLVVLPFAVFARLDDE------------QGRRQCVLVFPQP 195
Cdd:cd15395  93 LIAIERHQLIINPRGWRPNNRHAY-----VGIAViWVLAVLTSLPFLIFQVLTDEpfknvnvsldayKGKYVCLDQFPSD 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 196 EAfwwrasRL-YT---LVLGFAIPVSTICVLYTTLLCRL----HAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPY 267
Cdd:cd15395 168 TI------RLsYTtclLVLQYFGPLCFIFICYLKIYIRLkrrnNMMDKMRDNKYRSSETKRINIMLISIVVAFAVCWLPL 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 53828924 268 HL-STVVALTTDLPQT---PLVIAISYFITSLSyanSCLNPFLYAFLDASFRRNL 318
Cdd:cd15395 242 NIfNAVFDWNHEAIATcnhNLLFLICHLTAMIS---TCVNPIFYGFLNKNFQRDL 293
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
50-315 9.45e-18

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 81.77  E-value: 9.45e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIAD-FLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15928  13 VGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLYRlWRYRPWRFGDLLCRLMYFFSETCTYASILHIT 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVAGRtySAARAVSLAVWGIVTLVVLPFAVFARLDDEQGR-----RQCVLVFPQPEAFwwrAS 203
Cdd:cd15928  93 ALSVERYLAICHPLRAKVLVTR--GRVKLLIAVIWAVAIVSAGPALVLVGVEHIQGQqtprgFECTVVNVSSGLL---SV 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 RLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERA----KKRVTFLVVAILAVcLLCWTPYHLSTVVALTTDL 279
Cdd:cd15928 168 MLWVSTSFFFVPMVCLSLLYGLIGRALWDRRQRSRTAGASRRdnnhRQTVRMLAVIVLAF-VLCWLPFHVGRVIFNHSRA 246
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53828924 280 PQTPLVIAISYF-ITS--LSYANSCLNPFLYAFLDASFR 315
Cdd:cd15928 247 STKHLHYVSQYFnLVSfvLFYLSAAINPILYNLMSKRYR 285
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
52-316 1.01e-17

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 81.16  E-value: 1.01e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL-VLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVM 130
Cdd:cd15329  15 VVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALlVMPLAIIYELSGYWPFGEILCDVWISFDVLLCTASILNLCAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 131 SADRYLVVlaTAESRRVAGRTYSAARAVSLAVWGIVTLVVLPfAVFARLDDEQGRRQCVLVfpqpEAFWWrasRLYTLVL 210
Cdd:cd15329  95 SVDRYLVI--TRPLTYAVKRTPKRMALMIAIVWLLSALISIP-PLFGWKNKVNDPGVCQVS----QDFGY---QIYATFG 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 211 GFAIPVSTICVLYTTLLcrlhamrldshaKALERAKKRVTFLVVaILAVCLLCWTPYH-LSTVVALTTDLPQTPLVIAIS 289
Cdd:cd15329 165 AFYIPLIVMLVLYYKIY------------RAAKSERKAIKTLGI-IMGAFTLCWLPFFiLALLRPFLKPIKCSCIPLWLS 231
                       250       260
                ....*....|....*....|....*..
gi 53828924 290 YFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15329 232 RLFLWLGYANSFLNPIIYAKFNREFRT 258
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-315 1.10e-17

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 81.81  E-value: 1.10e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPI-NIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd16004  10 IVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAfNFVYASHNDWYFGLEFCRFQNFFPITAMFVSIY 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAGRTysaaRAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRAS-R 204
Cdd:cd16004  90 SMTAIAADRYMAIIHPFKPRLSAGST----KVVIAGIWLVALALAFPQCFYSTVTMDQGRTKCIVAWPGDSGGKHQLTyH 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALE-----RAKKRVTFLVVAILAVCLLCWTPYHLSTVV-ALTTD 278
Cdd:cd16004 166 LAVIVLIYLLPLAVMFVTYSIIGITLWRSAVPGHQAHGAyhrqlQAKKKFVKTMVVVVVTFAICWLPYHLYFILgSFNED 245
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53828924 279 LPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd16004 246 IYCQKYIQQVYLAIFWLAMSSTMYNPIIYCCLNQRFR 282
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
49-318 2.46e-17

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 80.64  E-value: 2.46e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  49 AVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPfGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15171  12 LVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWAHAAWHGGSL-GNPTCKVLVALSSVGLHSEALFNV 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLaTAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVL----VFPQPEAFWWRASR 204
Cdd:cd15171  91 LLTVQASRVFF-HGRLASSARRVAPCGIIASVLAWLTAFLVTLPEFVFYKPQMDSQKSKCAFsrphFLPAEETFWKYFLT 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTLVLGFAIPVSTICVLYttllcrlhaMRLDSHAKALERAKKRVTfLVVAILAVCLLCWTPYhlSTVVALTTDLPQTPL 284
Cdd:cd15171 170 LKMNIVVLVFPLLVFIICC---------VQLRKTQRFRERQRDLSK-LVFAIMVVFLLMWAPY--NIALFLSAFKEHFSL 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 53828924 285 -------VIAISYFITSL-SYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15171 238 rdckssyHLDASVQVTKLiATTHCCVNPLLYALLDPAFRRRL 279
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
47-315 2.55e-17

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 81.03  E-value: 2.55e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPF-----GELMCKLIVAIDQYNT 120
Cdd:cd15128  10 IFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYIVIdLPINVYKLLAMDWPFgdqpfGQFLCKLVPFIQKASV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 121 FSSLYFLTVMSADRYlvvLATAESRRVAGRTYSAARAVSLA-VWGIVTLVVLPFAV---FARLDDEQGRRQCVLVFPQPE 196
Cdd:cd15128  90 GITVLNLCALSVDRY---RAVASWSRIQGIGIPMWTAVEIVmIWMLSAVLAVPEAIgfdMVRFNYKGVTLRTCLLRPETS 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 197 --AFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKAL-ERAKKR--VTFLVVAILAVCLLCWTPYHLST 271
Cdd:cd15128 167 fmKFYIDVKDWWLFGFYFCLPLVCTAIFYTLMTCEMLRKRNGMLRIALnEHLKQRreVAKTVFCLVVIFALCWLPLHLSR 246
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 53828924 272 VVALTTDLPQTP-------LVIAISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15128 247 ILKLTVYDQNDPnrcellsFLLVLDYFGINLATLNSCINPIALYFVSRKFK 297
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
47-316 2.65e-17

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 80.05  E-value: 2.65e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINI-ADFLLRQWPFGELMCKLIVAIDQYNTFSSL 124
Cdd:cd15052  10 LVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVgLLVMPLSIlTELFGGVWPLPLVLCLLWVTLDVLFCTASI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAESRRVAGRTYSAARAVslAVWGIVTLVVLPFAVFARLDDEQ--GRRQCVLVFPqpeafwwrA 202
Cdd:cd15052  90 MHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIA--IVWLISIGISSPIPVLGIIDTTNvlNNGTCVLFNP--------N 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 SRLYTLVLGFAIPVSTICVLYTtllcrlhamrLDSHAKALERAKKRVTFLVVAILavcLLCWTPYHLSTVVALTTDLPQT 282
Cdd:cd15052 160 FVIYGSIVAFFIPLLIMVVTYA----------LTIRLLSNEQKASKVLGIVFAVF---VICWCPFFITNILTGLCEECNC 226
                       250       260       270
                ....*....|....*....|....*....|....
gi 53828924 283 PLVIAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15052 227 RISPWLLSVFVWLGYVSSTINPIIYTIFNKTFRR 260
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
48-315 6.24e-17

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 79.35  E-value: 6.24e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  48 CAVGLAGNSAVLYVLL-RAPRMKTVTNLFILNLAIADELFTLVLPINIADFLL-RQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15376  11 FLVAVLGNGLALWLFVtRERRPWHTGVVFSFNLAVSDLLYALSLPLLAAYYYPpKNWRFGEAACKLERFLFTCNLYGSIF 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRrvaGRTYSA-ARAVSLAVWGIVTLVVLPFAVFARLDDEQGRR-QCVLVFPQPEAFWWRAS 203
Cdd:cd15376  91 FITCISLNRYLGIVHPFFTR---SHVRPKhAKLVSLAVWLLVAALSAPVLSFSHLEVERHNKtECLGTAVDSRLPTYLPY 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 RLYTLVLGFAIPvsticvLYTTLLCRLHAMRLDSHAKALERA-KKRVTFLVVAILAVCLLCWTPYHLSTVVAL----TTD 278
Cdd:cd15376 168 SLFLAVVGCGLP------FLLTLASYLAIVWAVLRSPGITTLeKRKVAALVAVVVALYAVSFVPYHILRNLNLyrrlQWL 241
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53828924 279 LPQTPLVIAISYFITS-LSYANSCLNPFLYAFLDASFR 315
Cdd:cd15376 242 KAAASLRIYFAYQVTKgLVTLNMCIHPLLYMAVADSIR 279
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
47-315 1.14e-16

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 79.13  E-value: 1.14e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPF-----GELMCKLIVAIDQYNT 120
Cdd:cd15975  10 IFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYIVIdIPINVYKLLAQKWPFddssfGVFLCKLVPFLQKASV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 121 FSSLYFLTVMSADRYlvvLATAESRRVAGRTYSAARAVSL-AVWGIVTLVVLP----FAVFARLDDEQGRRQCVLVFPQP 195
Cdd:cd15975  90 GITVLNLCALSVDRY---RAVASWSRVQGIGIPLITAIEIfSIWVLSFILAIPeaigFVMVPFEYNGEQYRTCMLNATTK 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 196 -EAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMR-------LDSHAKALERAKKRVtFLVVAILAvclLCWTPY 267
Cdd:cd15975 167 fMNFYVDAKDWWLFGFYFCVPLACTAIFYTLMTCEMLNRRkgslriaLSEHLKQRREVAKTV-FCLVVIFA---LCWFPL 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 53828924 268 HLSTVVALTTDLPQTP-------LVIAISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15975 243 HLSRILKKTVYNENDPrrcellsFLLVMDYISINLATMNSCINPIALYFVSKKFK 297
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-315 1.32e-16

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 78.75  E-value: 1.32e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIAD---ELFTLVlpINIADFLLRQWPFGELMCKLIVAIDQYNTFSS 123
Cdd:cd16002  10 IVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEasmSAFNTV--INFTYAIHNEWYYGLEYCKFHNFFPIAAVFAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 124 LYFLTVMSADRYLVVLATAESRRVAgrtySAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQ-PEAFWWRA 202
Cdd:cd16002  88 IYSMTAIALDRYMAIIHPLQPRLSA----TATKVVICVIWVLAFLLAFPQGYYSDTEEMPGRVVCYVEWPEhEERKYETV 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 SRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRL--DSHAKALER--AKKRVTFLVVAILAVCLLCWTPYHLS-TVVALTT 277
Cdd:cd16002 164 YHVCVTVLIYFLPLLVIGCAYTVVGITLWASEIpgDSSDRYHEQvsAKRKVVKMMIVVVCTFAICWLPYHIYfLLQYFHP 243
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53828924 278 DLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd16002 244 ELYEQKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFR 281
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
44-318 2.59e-16

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 77.50  E-value: 2.59e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  44 YAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLR-QWPFGELMCKLIVAIDQYNTFS 122
Cdd:cd15368   7 YSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYHIQRnHWIFGKPLCNVVTVLFYANMYS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 123 SLYFLTVMSADRYLVVLATAESRRVAGRTYsaARAVSLAVWGIVTLVVLPfavFARLD-----DEQGRRQCVLVFPQ--- 194
Cdd:cd15368  87 SILTMTCISIERYLGVVYPMRSMRWRKKRY--AVAACIGMWLLVLTALSP---LERTDltyyvKELNITTCFDVLKWtml 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 195 PEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLhamrLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVA 274
Cdd:cd15368 162 PNIAAWAAFLFTLFILLFLIPFIITVYCYVLIILKL----VQTSERYGREQKRRAIYLALIVLLVFITCFAPNNFILLAH 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 53828924 275 LTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15368 238 MVSRLFYGKSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
50-316 3.33e-16

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 77.47  E-value: 3.33e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15073  13 ISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIgYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLLT 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVAGRTYSaarAVSLAVW-GIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWwrASRLYT 207
Cdd:cd15073  93 VVAVDRYLTICRPDLGRKMTTNTYT---VMILLAWtNAFFWAAMPLVGWASYALDPTGATCTINWRKNDSSF--VSYTMS 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 L-VLGFAIPVSTICVLYTTLLCRLH---AMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYhlsTVVALTTDLpQTP 283
Cdd:cd15073 168 ViVVNFIVPLAVMFYCYYNVSRFVKkvlASDCLESVNIDWTDQNDVTKMSVIMIVMFLVAWSPY---SIVCLWASF-GEP 243
                       250       260       270
                ....*....|....*....|....*....|....*
gi 53828924 284 LVIAISYFITSLSYANS--CLNPFLYAFLDASFRR 316
Cdd:cd15073 244 KKIPPWMAIIPPLFAKSstFYNPCIYVIANKKFRR 278
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
47-318 3.49e-16

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 77.13  E-value: 3.49e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIAdFLLRQ--WPFGELMCKLIVAIDQYNTFSSL 124
Cdd:cd15364  10 VFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTI-YVSNNhkWPWGSLACKITGYIFFCNIYISI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPfAVFARLDDEQGRRQCVLVFPQPE--AFWWRA 202
Cdd:cd15364  89 LLLCCISIDRFVAVVYALESRGR--RRQRIAAFISFLIFIVVGLVHSP-VFIMREGQTEGSHTCFETLQMDTqvAGFYYA 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 SrlytLVLGFAIPVSTICVLYTTLLCRLHA-MRLDSHAKAlerakkRVTFLVVAILAVCLLCWTPYHLSTVV-ALTTDLP 280
Cdd:cd15364 166 R----FCIGFAIPLAILIFTNYRIFRSIQTsTSLTPHQKA------KVKYLAIAVIVIFLICFAPYHLVLLVrAIAFSLY 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 53828924 281 QTPL------VIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15364 236 PNGMcgfeerIYTPSVIFLCLSTVNSVADPIIYVLVSENVRQDI 279
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
50-307 4.16e-16

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 77.14  E-value: 4.16e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRapRMKTV-TNLFILNLAIADELFTLVLPINIADFLL-RQWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15371  13 LGVPSNAIILWMLFF--RLRSVcTAIFYANLAISDLLFCITLPFKIVYHLNgNNWVFGETMCRIITITFYGNMYCSILLL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLATAESRRVAGRTYsaARAVSLAVWGIVTLVVLPFAVFAR--LDDEQGRRQCVLVFPQPEAFWWRASRL 205
Cdd:cd15371  91 TCISINRYLAIVHPFIYRSLPKKTY--AVLICALVWTIVFLYMLPFFILKQtyYLKELNITTCHDVLPECEQNSNFQFYY 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTL--VLGFAIPVSTICVLYTTLLCRLHAMrldsHAKALERAKkrVTFLVVAILAVcllCWTPyhlSTVVALTTDLPQTP 283
Cdd:cd15371 169 FISmaVFGFLIPLVITIFCYISIIRTLNAY----EHKWFWYVK--ITALVLIIFTI---CFAP---SNVILIIHHFNYYY 236
                       250       260
                ....*....|....*....|....*...
gi 53828924 284 LVIAISYFI----TSLSYANSCLNPFLY 307
Cdd:cd15371 237 FNNDNLYSIyliaLCLGSLNSCLDPFLY 264
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
52-315 4.79e-16

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 76.77  E-value: 4.79e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVM 130
Cdd:cd15063  15 VLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVgTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMCTASILNLCAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 131 SADRYLVVLATAESRRVAgrTYSAARAVSLAVWGIVTLVVLPFAVFA--RLDDEQGRRQCVLVFPQPEAFWWRASRLYTL 208
Cdd:cd15063  95 SLDRYLAITRPIRYPSLM--STKRAKCLIAGVWVLSFVICFPPLVGWndGKDGIMDYSGSSSLPCTCELTNGRGYVIYSA 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 209 VLGFAIPVSTICVLYttllcrlhaMRLDSHAKALERAKKRVTFLVVAIlavcLLCWTPYHLSTVVALTTDLPQTPLVIAI 288
Cdd:cd15063 173 LGSFYIPMLVMLFFY---------FRIYRAARMETKAAKTVAIIVGCF----IFCWLPFFTVYLVRAFCEDCIPPLLFSV 239
                       250       260
                ....*....|....*....|....*..
gi 53828924 289 SYFitsLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15063 240 FFW---LGYCNSALNPCIYALFSRDFR 263
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
50-316 4.99e-16

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 77.04  E-value: 4.99e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIA-DFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15148  13 FGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLLIICLPFRILyHVNNNQWTLGPLLCKVVGNLFYMNMYISIILLG 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVAGRTYSAarAVSLAVWGIVTLVVLPFAVfarLDDEQGRRQCVLVFPQPEAFWWRASRLYTL 208
Cdd:cd15148  93 FISLDRYLKINRSSRRQKFLTRKWSI--VACGVLWAVALVGFVPMIV---LTEKNEESTKCFQYKDRKNAKGKAIFNFLI 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 209 VLGFAIPVSTICVLYTTLLCRL-HAMRLDSH----AKALERAKKrvTFLVVAILAVcllCWTPYHLSTVVALTTDLPQTP 283
Cdd:cd15148 168 VAMFWLVFLLLILSYGKIAKKLlRISRDKPDfpnaAKYNRTARK--SFFVLFIFTV---CFVPYHAFRIFYITSQLQNNS 242
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53828924 284 -----LVIAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15148 243 cywkeILHKTNEIMLLLSAFNSCLDPVMYFLLSSSIRK 280
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
47-318 5.57e-16

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 77.02  E-value: 5.57e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRA-PRMKTVTNLFILNLAIADELFTL-VLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSL 124
Cdd:cd15383  10 LFVLSACSNLAVLWSATRNrRRKLSHVRILILHLAAADLLVTFvVMPLDAAWNVTVQWYAGDLACRLLMFLKLFAMYSSA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAESrrvaGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGR---RQCVLV--FPQPeafw 199
Cdd:cd15383  90 FVTVVISLDRHAAILNPLAI----GSARRRNRIMLCAAWGLSALLALPQLFLFHTVTATPPvnfTQCATHgsFPAH---- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 200 WR--ASRLYTLVLGFAIPVSTICVLYTTLLCRL-HAMR-LDSHAKA----------LERAKKRVTFLVVAILAVCLLCWT 265
Cdd:cd15383 162 WQetLYNMFTFFCLFLLPLLIMIFCYTRILLEIsRRMKeKKDSAKNevalrsssdnIPKARMRTLKMTIVIVSSFIVCWT 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 53828924 266 PYHLSTV---VALTTDLPQTPLVIAISYFITSLsyANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15383 242 PYYLLGLwywFSPEMLEQTVPESLSHILFLFGL--LNACLDPLIYGLFTISFRRGL 295
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
50-316 6.12e-16

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 76.40  E-value: 6.12e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15301  13 VTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVIsMPLFTVYTALGYWPLGYEVCDTWLAIDYLASNASVLNLL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRrvAGRTYSAARAVSLAVWGIvTLVVLPFAVFARLDDEqGRR-----QCVLVFPQPEAFwwraS 203
Cdd:cd15301  93 IISFDRYFSVTRPLTYR--ARRTTKKAAVMIASAWII-SLLLWPPWIYSWPYIE-GKRtvpagTCYIQFLETNPY----V 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 RLYTLVLGFAIPVSTICVLYTTLlcrlhamrLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVV-ALTTDLPQT 282
Cdd:cd15301 165 TFGTALAAFYVPVTIMCILYWRI--------WRETKKRQKKQESKAAKTLSAILLAFIVTWTPYNVLVLIkAFFPCSDTI 236
                       250       260       270
                ....*....|....*....|....*....|....*
gi 53828924 283 PLVI-AISYFitsLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15301 237 PTELwDFSYY---LCYINSTINPLCYALCNAAFRR 268
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
50-318 6.94e-16

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 76.59  E-value: 6.94e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV--LPI-NIADFlLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15337  13 LGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVngFPLkTISSF-NKKWIWGKVACELYGFAGGIFGFMSITT 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVtLVVLPFAVFARLDDEQGRRQCVLVFPQPEAfwwrASRLY 206
Cdd:cd15337  92 LAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLL-WSIPPFFGWGRYVPEGFQTSCTFDYLSRDL----NNRLF 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVL---GFAIPVSTICVLYTTLL--CRLHAMRLDSHAK-------ALERAKKRVTFLV--VAILAVC--LLCWTPYhls 270
Cdd:cd15337 167 ILGLfifGFLCPLLIIIFCYVNIIraVRNHEKEMTQTAKsgmgkdtEKNDARKKAEIRIakVAIILISlfLLSWTPY--- 243
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 53828924 271 TVVALTTdlpqtplVIAISYFITS--------LSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15337 244 AVVALLG-------QFGPAYWITPyvselpvmFAKASAIYNPIIYALSHPKFRAAL 292
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
52-325 8.49e-16

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 76.14  E-value: 8.49e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVM 130
Cdd:cd15307  15 AAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVaVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFCTASIMHLCTI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 131 SADRYLVVLATAESRRVAGRTYSAARAVslAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPeafwwrASRLYTLVL 210
Cdd:cd15307  95 SVDRYLSLRYPMRFGRNKTRRRVTLKIV--FVWLLSIAMSLPLSLMYSKDHASVLVNGTCQIPDP------VYKLVGSIV 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 211 GFAIPVSTICVLYTtLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLcWTPYHLSTVVALTTDLPQTPLVIAISY 290
Cdd:cd15307 167 CFYIPLGVMLLTYC-LTVRLLARQRSRHGRIIRLEQKATKVLGVVFFTFVIL-WSPFFVLNLLPTVCAECEERISHWVFD 244
                       250       260       270
                ....*....|....*....|....*....|....*
gi 53828924 291 FITSLSYANSCLNPFLYAFLDASFRRNLRQLITCR 325
Cdd:cd15307 245 VVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCR 279
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
47-318 1.17e-15

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 75.77  E-value: 1.17e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVL-PINIADFLLRQWPFGELMCklivaidQYNTFSSLY 125
Cdd:cd15074  10 IGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGyPLAIISAFAHRWLFGDIGC-------VFYGFCGFL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 F-------LTVMSADRYLVVLATAESRRVagrTYSAARAVSLAVWGIVTLV-VLPFAVFARLDDEQGRRQCVLVfpqpea 197
Cdd:cd15074  83 FgccsintLTAISIYRYLKICHPPYGPKL---SRRHVCIVIVAIWLYALFWaVAPLVGWGSYGPEPFGTSCSID------ 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 198 fWWRASR--------LYTLVLGFAIPVSTICVLYTTLLCRLHAMRL-----DSHAKALERAKKRVTFLVVAILAVCLLCW 264
Cdd:cd15074 154 -WTGASAsvggmsyiISIFIFCYLLPVLIIVFSYVKIIRKVKSSRKrvagfDSRSKRQHKIERKVTKVAVLICAGFLIAW 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 53828924 265 TPYhlsTVVALTTDLPQTPLVIAISYFITSLSYANSCL-NPFLYAFLDASFRRNL 318
Cdd:cd15074 233 TPY---AVVSMWSAFGSPDSVPILASILPALFAKSSCMyNPIIYLLFSSKFRQDL 284
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
47-316 1.18e-15

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 75.37  E-value: 1.18e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLA------GNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYN 119
Cdd:cd15322   4 IILVGLLmlltvfGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGKVWCEIYLALDVLF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 120 TFSSLYFLTVMSADRYLVVLATAESRrvAGRTYSAARAVSLAVWgiVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFW 199
Cdd:cd15322  84 CTSSIVHLCAISLDRYWSITQAIEYN--LKRTPRRIKCIIFIVW--VISAVISFPPLITIEKKSGQPEGPICKINDEKWY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 200 WrasrLYTLVLGFAIPvstiCVLYTTLLCRLHAMrldshAKALErakKRVTFLVVAILAVCLLCWTPYHLSTVVALTTD- 278
Cdd:cd15322 160 I----ISSCIGSFFAP----CLIMVLVYIRIYQI-----AKNRE---KRFTFVLAVVIGVFVICWFPFFFTYTLTAVCDc 223
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53828924 279 -LPQTplviaISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15322 224 sVPET-----LFKFFFWFGYCNSSLNPVIYTIFNHDFRR 257
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
47-315 1.23e-15

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 75.44  E-value: 1.23e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFT-LVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15064  10 IILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAvLVMPLSAVYELTGRWILGQVLCDIWISLDVTCCTASIL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVlaTAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCvLVFPQPeafwwrASRL 205
Cdd:cd15064  90 HLCVIALDRYWAI--TDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRTPDSEDPSEC-LISQDI------GYTI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYttllCRLHamrldsHAKALERakkRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLv 285
Cdd:cd15064 161 FSTFGAFYIPLLLMLILY----WKIY------RAAARER---KAAKTLGIILGAFIVCWLPFFLVALIVPLCSHCWIPL- 226
                       250       260       270
                ....*....|....*....|....*....|
gi 53828924 286 iAISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15064 227 -ALKSFFLWLGYFNSLINPLIYTFFNKDFR 255
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
47-318 2.08e-15

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 75.18  E-value: 2.08e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTnLFILNLAIADELFTLVLPINI-ADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15924  10 IFFAGILLNGLAMWIFFHIPSKSSFI-IYLKNTVVADLLMILTFPFKIlSDAGLGPWQLRTFVCRVTSVLFYFTMYTSIV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAGRTYsaARAVSLAVWGIVTLVVLPFAVfarLDDEQGRRQCV---LVFPQPEAFWWRA 202
Cdd:cd15924  89 FLGLISIDRYLKIVRPFKTSFPKSVSF--AKILSVVVWALMFLLSLPNMI---LTNQQPREKNVkkcSFLKSELGLKWHE 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 SRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKK--RVTFLVVAILAVCL----LCWTPYHLSTVVALT 276
Cdd:cd15924 164 IVNYICQVIFWIVFLLMIVCYTAITKKVYRSYRRVFRSSSSRRKKsnVKIFIIVAVFFVCFvpyhFARIPYTLSQTRDVF 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 53828924 277 TDLPQTPLVIAiSYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15924 244 DCTAENILFYV-KEATLFLSALNVCLDPIIYFFLCKSFRESL 284
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
52-307 3.35e-15

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 74.94  E-value: 3.35e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL-VLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVM 130
Cdd:cd15958  15 VAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLlVVPFGATLVVRGRWLYGSFFCELWTSVDVLCVTASIETLCVI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 131 SADRYLVVlaTAESRRVAGRTYSAARAVSLAVWGIVTLV-VLPFAVFARLDDEQGRRQCvlvFPQPEAFWWRASRLYTL- 208
Cdd:cd15958  95 AIDRYLAI--TSPFRYQSLLTRARAKGIVCTVWAISALVsFLPIMMHWWRDEDDQALKC---YEDPGCCDFVTNRAYAIa 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 209 --VLGFAIPVSTICVLYTTL----------LCRLHAMRLDSHAKALERAKKRVTFLVVA-----------ILAVCLLCWT 265
Cdd:cd15958 170 ssIISFYIPLLIMIFVYLRVyreakkqikkIDKCEGRFHNTLTGLGRKCKRRPSRILALreqkalktlgiIMGVFTLCWL 249
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 53828924 266 PYHLSTVV-ALTTDLPQTPLVIAISYfitsLSYANSCLNPFLY 307
Cdd:cd15958 250 PFFLVNVVnVFNRELVPDWLFVFFNW----LGYANSAFNPIIY 288
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
44-318 3.53e-15

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 74.84  E-value: 3.53e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  44 YAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLL-RQWPFGELMCKLIVAID----QY 118
Cdd:cd14996   7 YSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAAYFLKgFYWKYQSTQCRIANFFGtlviHV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 119 NTFSSLYFLTVMSADRYLVVLATAESRRVAG--------------RTYSAARAVSLAVWGIVTLVVLPFAVF--ARLDDE 182
Cdd:cd14996  87 SMCVSILILSWIAISRYATLMKHDSATQKQScyekifyghflkrfRQPKFARYLCIYIWGVVLCIIIPVVVYysVREADE 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 183 QGRRQCvlvFPQPEAFWWRASRLYTLVLGFAIPVSTICVL--YTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVC 260
Cdd:cd14996 167 DGESLC---YNRQVELGAKGSQIAGLIATTFFFLFFLVVLlsYYSFVNHLRRIQKNTCISEKDLIYRSVKRNILIIQALL 243
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 53828924 261 LLCWTPYHLSTVVAL----TTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd14996 244 VVCFLPYHIFKPVFYvlhqREDCQQLNYLIETKNILTCLASARSSTDPIMYLLLDKTFKKTL 305
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
47-318 4.11e-15

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 74.48  E-value: 4.11e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15396  10 VTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVCVMcIPFTAVYTLMDHWIFGETMCKLTSFVQSVSVSVSIF 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVlataesrrVAGRTYSAarAVSLAVWGIV------TLVVLPFAVFARLDDEQGRR------------Q 187
Cdd:cd15396  90 SLVLIAIERYQLI--------VNPRGWKP--SASHAYWGIVliwlfsLMISIPFLIFHQLTDEPFRNlsshsdfykdkvV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 188 CVLVFPQpeafwwRASRL-YT---LVLGFAIPVSTICVLYTTL---LCRLHAM---RLDSHAKALEraKKRVTFLVVAIL 257
Cdd:cd15396 160 CIEAWPS------ETERLiFTtslLVFQYFVPLGFIFICYLKIfvcLKKRNSKidrMRENESRLSE--NKRINTMLISIV 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 53828924 258 AVCLLCWTPYHLSTVV------ALTTdlPQTPLVIAISYFITSLSyanSCLNPFLYAFLDASFRRNL 318
Cdd:cd15396 232 VTFAACWLPLNIFNVVfdwnheVLMS--CHHNLVFTLCHLVAMVS---TCINPIFYGFLNKNFQKDL 293
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
55-316 4.28e-15

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 73.83  E-value: 4.28e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  55 NSAVLYVLLRAPRMKTVTNLFILNLAIADELFT-LVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSAD 133
Cdd:cd15334  18 NSLVITAIIVTRKLHHPANYLICSLAVTDFLVAvLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCTCSILHLSAIALD 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 134 RYLVVLATAESRRvaGRTYSAARAVSLAVWGIVTLVVLPfAVFARLDDEQGRRQCVLVFPQPeafwwrASRLYTLVLGFA 213
Cdd:cd15334  98 RYRAITDAVEYAR--KRTPKHAGIMIAVVWIISIFISMP-PLFWRHQTTSREDECIIKHDHI------VFTIYSTFGAFY 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 214 IPVSTICVLYTTLLcrlhamrldshaKALERAKKRVTFLVVaILAVCLLCWTPYHLSTVVALTTDlpQTPLVIAISYFIT 293
Cdd:cd15334 169 IPLALILILYYKIY------------RAATRERKAATTLGL-ILGAFVICWLPFFVKEVIVNTCD--SCYISEEMSNFLT 233
                       250       260
                ....*....|....*....|...
gi 53828924 294 SLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15334 234 WLGYINSLINPLIYTIFNEDFKK 256
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
50-318 4.86e-15

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 74.09  E-value: 4.86e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADelftLVLpinIADFLLRQWPFGE------LMCKLIVAIDQYNTFSS 123
Cdd:cd14989  13 IGFIGNILILVVNLSFREKMTIPDLYFVNLAVAD----LIL---VADSLIEVFNLNEkyydiaVLCTFMSLFLQINMYSS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 124 LYFLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVW-GIVTLVVLPF-AVFARLDDEQgrrqCVLVFPQPEAFWWR 201
Cdd:cd14989  86 IFFLTWMSFDRYIALAKVMKSSPL--RTMQHARLSCGLIWmASISATLLPFtAVQAQHTGEV----HFCFADVREIQWLE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 202 asrlytLVLGFAIPVSTICVLYTTLLCRLhaMRLDSHAKALERAKKRVTFLVVAILaVCLLCWTPYHLSTVVAL--TTDL 279
Cdd:cd14989 160 ------VTLGFIIPFSIIGLCYSLIVRVL--VRAQKHRRLRPRRQKALRMILVVVL-VFFICWLPENVFISIQLlqGTQE 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 53828924 280 PQTPLVIA-------ISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd14989 231 PSESYDESfrhnhplTGHIVNLAAFSNSCLNPLIYSFLGETFRDKL 276
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
51-318 5.08e-15

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 73.99  E-value: 5.08e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  51 GLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVM 130
Cdd:cd15152  14 GLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVLSLPLRIFYYLNKSWPFGKFLCMFCFYLKYVNMYASIYFLVCI 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 131 SADRYLVVLATAesrRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFaRLDDEQGRRQCVLVFPQPEAFWWRASRLYTL-- 208
Cdd:cd15152  94 SVRRCLYLIYPF---RYNDCKRKCDVYISIAGWLVVCVGCLPFPLL-RQSQDTNPTCCFADLPLRNVGLTTSVIMLTIae 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 209 VLGFAIP--VSTICVLYTTLLCRLHAMRLDSHAKaleraKKRVTFLVVAILAVCLLCWTPYHLSTVVALTT------DLP 280
Cdd:cd15152 170 LTGFVTPllIVLYCSWKTVMSLREKTPVLQDLGE-----KKKALKMILTCAVVFLICFAPYHISFPLDFLVksnkikSCT 244
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53828924 281 QTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15152 245 ARKVILIFHPVALCLASLNSCLDPVIYYFTTDEFKRRL 282
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
55-315 5.37e-15

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 73.42  E-value: 5.37e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  55 NSAVLYVLLRAPRMKTVTNLFILNLAIADELFT-LVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSAD 133
Cdd:cd15335  18 NSAVIAAICTTKKLHQPANYLICSLAVTDFLVAvLVMPLSITYIVMDTWTLGYFICEIWLSVDMTCCTCSILHLCVIALD 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 134 RYLVVLATAESRRvaGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLvfpQPEAFWWrasRLYTLVLGFA 213
Cdd:cd15335  98 RYWAITDAIEYAR--KRTAKRAGLMILTVWTISIFISIPPLFWRNHHDANIPSQCII---QHDHVIY---TIYSTFGAFY 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 214 IPVSTICVLYTTLLcrlhamrldsHAKALERAKKRVTFLvvaILAVCLLCWTPYHLSTVVALTTDLPQTPLViaiSYFIT 293
Cdd:cd15335 170 IPLTLILILYYRIY----------HAASRERKAARILGL---ILGAFILSWLPFFIKELIVGLSVMTVSPEV---ADFLT 233
                       250       260
                ....*....|....*....|..
gi 53828924 294 SLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15335 234 WLGYVNSLVNPLLYTSFNEDFK 255
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
50-316 6.15e-15

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 73.41  E-value: 6.15e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15327  13 MAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLsTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTASILSLC 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVAgrTYSAARAVSLAVWgIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPeafwwrASRLYTL 208
Cdd:cd15327  93 VISVDRYVGVKHSLKYPTIM--TERKAGVILVLLW-VSSMVISIGPLLGWKEPPPPDESICSITEEP------GYALFSS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 209 VLGFAIPVSTICVLYttllCRLHAMRLDshakaLERAKKRVTFLVVaILAVCLLCWTPYHLstVVALTTDLPQTPLVIAI 288
Cdd:cd15327 164 LFSFYLPLMVILVMY----FRVYVVALK-----FSREKKAAKTLAI-VVGVFILCWFPFFF--VLPLGSFFPALKPSEMV 231
                       250       260
                ....*....|....*....|....*...
gi 53828924 289 SYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15327 232 FKVIFWLGYFNSCVNPIIYPCSSKEFKR 259
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
51-317 6.67e-15

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 73.64  E-value: 6.67e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  51 GLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFlLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVM 130
Cdd:cd15923  14 GLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLISLPFKMHSY-RRESAGLQKLCNFVLSLYYINMYVSIFTITAI 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 131 SADRYLVVLATAESRRVagRTYSAARAVSLAVWgiVTLVVLPFAVFArLDDEQGRRQCvlvFPQPEAFWWRASRLYTLVL 210
Cdd:cd15923  93 SVDRYVAIRYPLRAREL--RSPRKAAVVCAVIW--VLVVTISIPYFL-LDSSNEKTMC---FQRTKQTESLKVFLLLEIF 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 211 GFAIPVSTICVLYTTLLCRLHAMRLDSHAKAlerAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISY 290
Cdd:cd15923 165 GFLLPLIIMTFCSARVIHTLQKRLDDVGSRS---ETKQCIRVIMANLIVFIVCFLPVHVGFFVKFIVGKSYSCDSKLIIH 241
                       250       260       270
                ....*....|....*....|....*....|.
gi 53828924 291 FIT----SLSYANSCLNPFLYAFLDASFRRN 317
Cdd:cd15923 242 FFLqsafCLSDMNCCLDAFCYYFATKEFREA 272
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
50-307 7.07e-15

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 73.63  E-value: 7.07e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15384  13 ISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFcIPSEAIWAYTVAWLAGNTMCKLVKYLQVFGLYLSTYITV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVAGRtysaARAVSLAVWGIVTLVVLPFAVFARLddEQGRR-----QCVLVFPQPEAFWWRAS 203
Cdd:cd15384  93 LISLDRCVAILYPMKRNQAPER----VRRMVTVAWILSPIFSIPQAVIFHV--ERGPFvedfhQCVTYGFYTAEWQEQLY 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 RLYTLVLGFAIPvstICVLYTTLLCRLHamRLDSHAKA------------------LERAKKRVTFLVVAILAVCLLCWT 265
Cdd:cd15384 167 NMLSLVFMFPIP---LVIMVTCYVLIFI--TLSKSSRDfqgleiytrnrgpnrqrlFHKAKVKSLRMSAVIVTAFILCWT 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 53828924 266 PYHlsTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLY 307
Cdd:cd15384 242 PYY--VIMIWFLFFNPYPLNDILFDVIFFFGMSNSCVNPLIY 281
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
47-318 8.23e-15

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 73.28  E-value: 8.23e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIaDFLLRQ--WPFGELMCKLIVAIDQYNTFSSL 124
Cdd:cd15365  10 VIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLWI-DYLWNGdnWTLSGFVCIFSAFLLYTNFYTST 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVlpfAVFARLDD----EQGRRQCVLVFPQPEafwW 200
Cdd:cd15365  89 ALLTCIALDRYLAVVHPLKFMHL--RTIRTALSVSVAIWLLEICFN---AVILTWEDsfheSSSHTLCYDKFPLED---W 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 201 RAS-RLYTLVLGFAIPVSTIcvlyttLLCRLHAMRLDSHAKALE-RAKKRVTFLVVAILAVCLLCWTPYHLSTVVAlTTD 278
Cdd:cd15365 161 QARlNLFRICLGYLLPLLII------LFCYWKIYQAVRSNQATEdQEKKKIFKLLLLITVTFVICFTPYHVVLLIR-SIV 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 53828924 279 LPQTPLVIAISYFITSLSYANSCLN----PFLYAFLDASFRRNL 318
Cdd:cd15365 234 EPCDCRNAKWLYTLYKITVALTSLNciadPFLYCFVTESGRADI 277
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
47-318 9.18e-15

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 73.25  E-value: 9.18e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNL--FILNLAIADELFTLVLPINIaDFLLRQ--WPFGELMCKLIVAIDQYNTFS 122
Cdd:cd15147  10 IFVLGLIANCYVLWVFARLYPSKKLNEIkiFMVNLTIADLLFLITLPFWI-VYYHNEgnWILPKFLCNVAGCLFFINTYC 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 123 SLYFLTVMSADRYLVVLATAESRRVAGRTYSAarAVSLAVWGIVTLVVLPFAVFARLDDEQ-GRRQCVLVFPQPEafwwR 201
Cdd:cd15147  89 SVAFLGVISYNRYQAVTRPIKTAQSTTRKRGI--IISVAIWVIIVASASYFLFMDSTNTVKiDSGNFTRCFEGYE----K 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 202 ASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALER----AKKRVTFLVVAILAVCLLCWTPYH-------LS 270
Cdd:cd15147 163 DNSKPVLIIHFIIIGLFFLVFLLILVCNLVIARTLLSQPVQGQrnagVKRRALWMVCTVLAVFVICFVPHHvvqgpwtLA 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 53828924 271 TVVALTTDLPQTPLVIAISYFITSLSYANSC-LNPFLYAFLDASFRRNL 318
Cdd:cd15147 243 VLQQWRYWDCQFRQALNDAHQITLCLMSTNCvLDPVIYCFLTKKFRKHL 291
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
50-318 1.00e-14

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 72.69  E-value: 1.00e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADeLFTLVLPINIADF--LLRQWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15297  13 VTIIGNILVMVSIKVNRHLQTVNNYFLFSLACAD-LIIGVFSMNLYTLytVIGYWPLGPVVCDLWLALDYVVSNASVMNL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVV-----LATAESRRVAGRTYSAARAVSLAVWGIVTLvVLPFAVFARLDDEqgrRQCVLVFpqpeaFWWRA 202
Cdd:cd15297  92 LIISFDRYFCVtkpltYPVKRTTKMAGMMIAAAWVLSFILWAPAIL-FWQFIVGGRTVPE---GECYIQF-----FSNAA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 SRLYTLVLGFAIPVSTICVLYTTLlcrlhamrldshAKALERAKKrVTFLVVAILAVCLLCWTPYHLSTVVAL--TTDLP 280
Cdd:cd15297 163 VTFGTAIAAFYLPVIIMTVLYWQI------------SRASSREKK-VTRTILAILLAFIITWTPYNVMVLINTfcASCIP 229
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53828924 281 QTplVIAISYFitsLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15297 230 NT--VWTIGYW---LCYINSTINPACYALCNATFKKTF 262
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-315 1.31e-14

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 72.91  E-value: 1.31e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFL-LRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15132  10 LFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPFDLYRLWkSRPWIFGEFLCRLYHYISEGCTYATIL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAGRTysAARAVSLAVWGIVTLVVLP--FAVFARLDDEQGR----RQCvlvfpQPEAFW 199
Cdd:cd15132  90 HITALSIERYLAICFPLRAKVLVTRR--RVKCVIAALWAFALLSAGPflFLVGVEQDNNIHPddfsREC-----KHTPYA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 200 WRASRLYTLV----LGFAIPVSTICVLYTTLLCRLHAMRLD---SHAKALERAKKR-VTFLVVAILAVcLLCWTPYHLST 271
Cdd:cd15132 163 VSSGLLGIMIwvttTYFFLPMLCLSFLYGFIGRKLWKSKNDlrgPNAAARERSHRQtVRILAVVVLAF-IICWLPFHIGR 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 53828924 272 VVALTTDLPQTPLVIA-ISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15132 242 ILFANTEDYRTMMFSQyFNIVAMQLFYLSASINPILYNLISRKYR 286
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
50-318 1.45e-14

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 72.49  E-value: 1.45e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLR-QWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15367  13 VGLPANCLSLYYGYLQIKAKNELGIYLCNLTVADLLYIFSLPFWLQYVLQHdNWTYSELLCKICGILLYENIYISIGFLC 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAesRRVAGRTYSAARAVSLAVWG---IVTLVVLPFAVFARldDEQGRRQCVLVFPQPEafWWRASRL 205
Cdd:cd15367  93 CISVDRYLAVVHPF--RFHAFRTMKAATLVSTVIWLkelMTCVFFFLHGEISK--DKENHSVCFEHYPIKA--WEHNINY 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPvstICVLYTTLLCRLHAMRlDSHAKAlERAKKRVTFLVVAILAVCLLCWTPYHLSTVV--ALTTDLPQTP 283
Cdd:cd15367 167 YRFYAGFLFP---IFLLSFSYCRILRAVR-KSHGTQ-KSQKIQIKRLVLSTVVIFLVCFGPYHILLLVrsVFERDCNFAE 241
                       250       260       270
                ....*....|....*....|....*....|....*
gi 53828924 284 LVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15367 242 GIFNYYHFSLLLTSFNCVADPVLYCFASESTYHDF 276
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
47-316 1.47e-14

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 72.46  E-value: 1.47e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIAD-ELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15060  10 IIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADlAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCCTASIL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVlaTAESRRVAGRTYSAARAVSLAVWGIVTLVVLP--FAVFARLDDEQGRRQCVLVFPqpeafwwRAS 203
Cdd:cd15060  90 NLCAIALDRYWAI--HDPINYAQKRTLKRVLLMIVVVWALSALISVPplIGWNDWPENFTETTPCTLTEE-------KGY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 RLYTLVLGFAIPVSTICVLYTTLLcrlhamrldsHAKALERAKKRVtflVVAILAVCLLCWTPYHLSTV-VALTTDLPQT 282
Cdd:cd15060 161 VIYSSSGSFFIPLLIMTIVYVKIF----------IATSKERRAART---LGIIMGVFVVCWLPFFLMYViLPFCETCSPS 227
                       250       260       270
                ....*....|....*....|....*....|....
gi 53828924 283 PLVIAisyFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15060 228 AKVVN---FITWLGYVNSALNPVIYTIFNLDFRR 258
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
51-315 2.10e-14

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 71.93  E-value: 2.10e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  51 GLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFT-LVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15330  14 AIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSvLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLVVlaTAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPeafwwrASRLYTLV 209
Cdd:cd15330  94 IALDRYWAI--TDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWRTPEDRSDPDACTISKDP------GYTIYSTF 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 210 LGFAIPVSTICVLYTTLLcrlhamrldshaKALERAKKRVTFLVVaILAVCLLCWTPYHLSTVV----ALTTDLPQtpLV 285
Cdd:cd15330 166 GAFYIPLILMLVLYGRIF------------KAAARERKTVKTLGI-IMGTFILCWLPFFIVALVlpfcESTCHMPE--LL 230
                       250       260       270
                ....*....|....*....|....*....|
gi 53828924 286 IAIsyfITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15330 231 GAI---INWLGYSNSLLNPIIYAYFNKDFQ 257
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
50-316 2.35e-14

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 71.85  E-value: 2.35e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15326  13 FAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLsFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSLC 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVAGRtySAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVfpqPEAFWwrasRLYTL 208
Cdd:cd15326  93 AISIDRYIGVRHSLQYPTIVTR--KRAILALLGVWVLSTVISIGPLLGWKEPAPPDDKVCEIT---EEPFY----ALFSS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 209 VLGFAIPVSTICVLYttllCRLHAMrldshAKALERAKKRVTFLVVaILAVCLLCWTPYHLSTVVALTTDLPQTPlvIAI 288
Cdd:cd15326 164 LGSFYIPLIVILVMY----CRVYIV-----ALKFSREKKAAKTLGI-VVGMFILCWLPFFIALPLGSLFSHLKPP--ETL 231
                       250       260
                ....*....|....*....|....*...
gi 53828924 289 SYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15326 232 FKIIFWLGYFNSCLNPIIYPCSSKEFKR 259
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
50-269 3.50e-14

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 71.75  E-value: 3.50e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQ-WPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15366  13 LGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLWIDYFLHRDnWIHGPESCKLFGFIFYTNIYISIAFLC 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVV---LATAESRRVagrtySAARAVSLAVWGI-VTLVVLPFAVFARLDDEQGRRQCVLVFPQPEafWWRASR 204
Cdd:cd15366  93 CISVDRYLAVahpLRFAKVRRV-----KTAVAVSAVVWAIeIGANSAPLFHDELFRDRYNHTFCFEKYPMED--WVAWMN 165
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 53828924 205 LYTLVLGFAIPVSTICVLYTTLlcrLHAMRLDSHAKALERAKkrVTFLVVAILAVCLLCWTPYHL 269
Cdd:cd15366 166 LYRVFVGFLFPWVLMLFSYRGI---LRAVRGNVSTEQQEKAK--IKRLALSLIAIVLLCFAPYHV 225
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
52-318 4.41e-14

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 71.46  E-value: 4.41e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVL-PINIADFLLR--------QWpFGELMCKLIVAIDQYNTFS 122
Cdd:cd15137  15 LLGNLFVLIWRLKYKEENKVHSFLIKNLAIADFLMGVYLlIIASVDLYYRgvyikhdeEW-RSSWLCTFAGFLATLSSEV 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 123 SLYFLTVMSADRYLVVLATAESRRVagrTYSAARAVSLAVWGIVTLV-VLPFAVFARLDDEQGRRQCVLVFP--QPEAFW 199
Cdd:cd15137  94 SVLILTLITLDRFICIVFPFSGRRL---GLRRAIIVLACIWLIGLLLaVLPLLPWDYFGNFYGRSGVCLPLHitDERPAG 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 200 WRASRLYTLVLGFAIPVsTICVLYTTLLCRLHAMRL--DSHAKALERAKKRVTFLVVAILAvclLCWTPYHLSTVVALT- 276
Cdd:cd15137 171 WEYSVFVFLGLNFLAFV-FILLSYIAMFISIRRTRKaaASRKSKRDMAVAKRFFLIVLTDF---LCWIPIIVIGILALSg 246
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 53828924 277 TDLPQTplVIA-ISYFITSLsyaNSCLNPFLYAFLDASFRRNL 318
Cdd:cd15137 247 VPIPGE--VYAwVAVFVLPI---NSALNPILYTLSTPKFRKKL 284
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
47-315 5.33e-14

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 71.34  E-value: 5.33e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADfLLRQWPF--GELMCKLIVAIDQYNTFSS 123
Cdd:cd15358  10 IFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVLLLgMPLELYE-MWSNYPFllGAGGCYFKTLLFETVCFAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 124 LYFLTVMSADRYLVVLATAESRRVAGRTYsaARAVSLAVWGIVTLVVLP---------FAVFARlDDEQGRRQCVLVFPq 194
Cdd:cd15358  89 ILNVTALSVERYIAVVHPLKAKYVVTRTH--AKRVIGAVWVVSILCSIPntslhgifqLTVPCR-GPVPDSATCMLVKP- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 195 peAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRL--------------DSHAKALERAKKR--VTFLVVAILA 258
Cdd:cd15358 165 --RWMYNLIIQITTLLFFFLPMGTISVLYLLIGLQLKREKMllvleakgskagdsYQHRRIQQEKRRRrqVTKMLFVLVV 242
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 259 VCLLCWTPYHLSTVVALTTDLPQTPLVIAISYF-ITS--LSYANSCLNPFLYAFLDASFR 315
Cdd:cd15358 243 VFGICWAPFHTDRLMWSFISQWTGELHLAFQYVhIISgvFFYLSSAANPVLYNLMSTRFR 302
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
50-316 6.11e-14

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 70.75  E-value: 6.11e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMK-TVTNLFILNLAIADELFTLVLPINIAD-FLLRQWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15170  13 IGLPANLLAFYTFIRKVRRKpTPIDILLLNLTVSDLIFLLFLPFKMAEaASGMIWPLPYFLCPLSSFIFFSTIYISTLFL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLATAESRRVAGRTYsaARAVSLAVW-------GIVTLVVlpFAVFARLDDEQGRRQCVLVFPQPEAFWW 200
Cdd:cd15170  93 TAISVERYLGVAFPIKYKLRRRPLY--AVIASVFFWvlafshcSIVYIVE--YHIDSENTSVTNNSRCYDNFTPEQLKIL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 201 RASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKaleraKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDlp 280
Cdd:cd15170 169 LPVRLELFLVLFCIPFLITCFCYINFIRILSSLPHISRQR-----KQRAIGLAVATLLNFIVCFAPYNISHVVGFIQR-- 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 53828924 281 QTPlviAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15170 242 KSP---EWRMYALLLSTLNACLDPIIFYFSSSAVRR 274
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
74-316 6.49e-14

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 70.85  E-value: 6.49e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  74 LFILNLAIADELFTLVLPINiADFLLR--QWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATaeSRRVAGRT 151
Cdd:cd15201  37 VYLFNLAVADFLLIICLPFR-TDYYLRgkHWKFGDIPCRIVLFMLAMNRAGSIFFLTAVAVDRYFRVVHP--HHRINSIS 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 152 YSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQC----VLVFPQPEAFWWRasrlYTLVLGFAIPVSTICVLYTTLL 227
Cdd:cd15201 114 VRKAAIIACGLWLLTIAMTVYLLTKKHLFPRGNATQCesfnICTGTDSSSNWHE----AMFLLEFFLPLAIILYCSVRII 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 228 CRLHAMRLDSHAKAlerakKRVTFLVVAILAVCLLCWTPYHLSTVVALTT------DLPQTPLViAISYFIT-SLSYANS 300
Cdd:cd15201 190 WQLRGRQLDRHAKI-----KRAVQFIMVVAIVFIICFLPSNVTRIAIWILkhtsneDCQYYRSV-DLAFYITiSFTYFNS 263
                       250
                ....*....|....*.
gi 53828924 301 CLNPFLYAFLDASFRR 316
Cdd:cd15201 264 MLDPVVYYFSSPSFKN 279
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
47-316 6.72e-14

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 70.28  E-value: 6.72e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15324  10 IILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVaTLVIPFSLANEVMGYWYFGSTWCAFYLALDVLFCTSSIV 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVlaTAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDeqgrRQCVLVfpqpEAFWWrasRL 205
Cdd:cd15324  90 HLCAISLDRYWSV--TKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMTKHDE----WECLLN----DETWY---IL 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPvstiCVLYTTLLCRLHamrldshaKALERAKKRVTFLVVAILAVCLLCWTP----YHLSTVVALTTDLPQ 281
Cdd:cd15324 157 SSCTVSFFAP----GLIMILVYCKIY--------RVAKMREKRFTFVLAVVMGVFVLCWFPffftYSLHAVCRKRCGIPD 224
                       250       260       270
                ....*....|....*....|....*....|....*
gi 53828924 282 tplviAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15324 225 -----ALFNLFFWIGYCNSSVNPIIYTIFNRDFRK 254
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
47-315 7.42e-14

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 70.21  E-value: 7.42e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFllrqWPFGELMCKLIVAIDQY--NTFSSL 124
Cdd:cd15163  10 IFLVGIVLNSLALYVFCFRTKTKTTSVIYTINLVVTDLLVGLSLPTRIVMY----YSAGNCLTCSFVHIFSYfvNMYCSI 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAESRRVAGRTYsaARAVSLAVW---GIVTLVVLPFAVfarlddeqGRRQCVLvfpqpeafwwr 201
Cdd:cd15163  86 LFLTCICVDRYLAIVQVEASRRWRNPNY--AKGICVFIWlfaIVVTFSILTTAI--------KFASCCL----------- 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 202 aSRLYTL-VLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKalERAKKRVTfLVVAILAVCLLCWTPYHLSTVVALTTDLP 280
Cdd:cd15163 145 -SKLFALtVFEFFLPLLIITFFTIRIMCALSRPGLMHQSR--ERRMRAVQ-LLITVLIIFMICFTPFHVRQVAVAFNPDI 220
                       250       260       270
                ....*....|....*....|....*....|....*
gi 53828924 281 QTPLVIAISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15163 221 PHHTSLIVYHVTVTLSSLNSCMDPIVYCFVTNNFQ 255
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
48-315 9.11e-14

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 70.21  E-value: 9.11e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  48 CAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFL-LRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15199  11 FGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYFYLnGNRWSLGGGTCKALLFMLSLSRGVSIAF 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLataesrRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDE-QGRRQCVLVFPQPEAFWWRASRL 205
Cdd:cd15199  91 LTAVALDRYFRVV------HPRGKKNSLSLQAAPYISFLVWLLLVGLTIPTLLASQpKNFTECNSFSPKDDEDFSDTWQE 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLHAMRLD-SHAKALERAkkrvTFLVVAILAVCLLCWTPYHLSTVVAL---TTDLPQ 281
Cdd:cd15199 165 AVFFLQFLLPFGLIVFCTVRIIRRLKKRLRDvGKQPKLQRA----MALVTSVVVVFGFCFLPCFLARVLMLifqNKESCN 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 53828924 282 TPLVIAISYFIT-SLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15199 241 ALNIAVHTYDVTmCLTYLNSVLDPIVYCFSSPTFR 275
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
47-316 9.27e-14

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 70.61  E-value: 9.27e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPIN--IADFLLRQWPFGELMCKLIVAIDQYNTFSSL 124
Cdd:cd15198  10 ILVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLVIGGTALSqiIWELLGDRWMAGDVACRLLKLLQASARGASA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAESRRvagrtysAARAVSLAVWGIVTLVVLPFAVFARLD-------DEQGRRQCVLVFPQPEA 197
Cdd:cd15198  90 NLVVLLALDRHQAIRAPLGQPL-------RAWKLAALGWLLALLLALPQAYVFRVDfpddpasAWPGHTLCRGIFAPLPR 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 198 FWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAK------------------ALERAKKRVTFLVVAILAV 259
Cdd:cd15198 163 WHLQVYATYEAVVGFVAPVVILGVCYGRLLLKWWERANQAPGAkkpwkkpskshlratapsALPRAKVKTLKMTLVIALL 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 53828924 260 CLLCWTPYHLSTVVALTTDLPQTPlvIAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15198 243 FVGCSLPYFIAELAAAFGSGDWEP--EKVAAALGVMAVANSATNPFVFLFFNAGDCR 297
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
47-316 1.01e-13

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 70.11  E-value: 1.01e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPI-NIADFLL--RQWPFGELMCKLIVAIDQYNTFSS 123
Cdd:cd14995  10 ICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAGLpNEIESLLgpDSWIYGYAGCLLITYLQYLGINAS 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 124 LYFLTVMSADRYLVVLATAESRRVAgrTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVlvfpqpEAFWWRAS 203
Cdd:cd14995  90 SLSITAFTIERYIAICHPMKAQFIC--TVSRAKKIICFVWIFTSLYCSPWLFLLDLSIKHYGDDIV------VRCGYKVS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 RLYTL-------VLGFAIPVSTICVLYTTLlcrlhamrldshAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALT 276
Cdd:cd14995 162 RHYYLpiyladfVLFYVIPLLLAIVLYGLI------------GRILFSSRKQVTKMLAVVVVLFALLWMPYRTLVVYNSF 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 53828924 277 TDLPQTPLVIAIsyFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd14995 230 ASPPYLDLWFLL--FCRTCIYLNSAINPILYNLMSQKFRA 267
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
50-315 1.10e-13

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 70.17  E-value: 1.10e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIA-DFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15167  13 IGFIGSCFALWAFIQKRSSRKCINIYLINLLTADFLLTLALPVKIAvDLGIAPWKLKIFHCQVTACLIYINMYLSIIFLG 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVAGRTYsaARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRAsrlYTL 208
Cdd:cd15167  93 FVSIDRYLQLTHSSKLYRIQEPGF--AKMISAVVWTLVLFIMVPNMAIPIKTIEEKPGVGCADFKTEFGRHWHV---LTN 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 209 VLGFAI--PVSTICVLYTTLLCRlhamRLDSHAKALERAKKRVTFLVVAIL-AVCLLCWTPYHlstVVALTTDLPQTPLV 285
Cdd:cd15167 168 FICMAIflNFSAIILISNFLVIR----KLYRNKDSEEYRNARQALVNILLVtAGYVICFVPYH---IVRIPYTLSQSEVI 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53828924 286 ----IAISYFITS-----LSYANSCLNPFLYAFLDASFR 315
Cdd:cd15167 241 tdcsLKRSLFLAKestllLAVLNLCFDPILYFHLSKAFR 279
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
47-316 2.19e-13

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 68.94  E-value: 2.19e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL-VLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15066   9 IILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALcAMTFNASVEITGRWMFGYFMCDVWNSLDVYFSTASIL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAgrTYSAARAVSLAVWGIVTLV-VLPF--AVFARLDDEQGRRQcvlvfpQPEAFWWRA 202
Cdd:cd15066  89 HLCCISVDRYYAIVQPLEYPSKM--TKRRVAIMLANVWISPALIsFLPIflGWYTTEEHLQYRKT------HPDQCEFVV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 SRLYTLV---LGFAIPvsTICVLYTTLLCRLHAMRLDSHAKALErakkrvtflvvAILAVCLLCWTPYHLSTVVALT--T 277
Cdd:cd15066 161 NKIYALIsssVSFWIP--CIVMIFTYYRIYLEAKREHKAAKTLG-----------IIMGAFILCWLPFFLWYVTTTLcgD 227
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53828924 278 DLPQTPLVIAISYFItslSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15066 228 ACPYPPILVSILFWI---GYFNSTLNPLIYAYFNRDFRE 263
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
47-318 2.34e-13

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 69.36  E-value: 2.34e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15336  10 IGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTqSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITSMI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAGRTYSAarAVSLAVWgIVTLV--VLPFAVFARLDDEQGRRQCVLVFPQPEAfwwrAS 203
Cdd:cd15336  90 TLLAISLDRYLVITKPLASIRWVSKKRAM--IIILLVW-LYSLAwsLPPLFGWSAYVPEGLLTSCTWDYMTFTP----SV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 RLYTLVLG---FAIPVSTI--CVLYTTLLCR--------LHAMRLDSHAKALERAKKRVTFLVVAILAVCL--LCWTPYH 268
Cdd:cd15336 163 RAYTMLLFcfvFFIPLGIIiyCYLFIFLAIRstgrevqkLGSQDRKEKAKQYQRMKNEWKMAKIAFVVILLfvLSWSPYA 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 53828924 269 LSTVVA-------LTTDLPQTPLVIAisyfitslsYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15336 243 CVALIAwagyahlLTPYMKSVPAVIA---------KASAIYNPIIYAITHPKYREAI 290
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
52-316 2.68e-13

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 69.08  E-value: 2.68e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVM 130
Cdd:cd15981  15 MVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVgIFCMPTTLVDNLITGWPFDNAMCKMSGLVQGMSVSASVFTLVAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 131 SADRYLVVLATAESRrvagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGR------------RQCVLVFPQPEaf 198
Cdd:cd15981  95 AVERFRCIVHPFRQK----LTLRKAIVTIVIIWVLALIIMCPSAVTLTVTREEHHfmvddynnsyplYSCWEAWPDTE-- 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 199 wwrASRLYTLVLG---FAIPVSTICVLYTTL---LCRLHAMRLDSHAKALE-----RAKKRVTFLVVAILAVCLLCWTPy 267
Cdd:cd15981 169 ---MRKIYTTVLFshiYLAPLTLIVIMYARIafkLFKSSAPIRGSQGEEEEgrrvsKRKIKVINMLIIVALFFTLSWLP- 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 53828924 268 hLSTVVALTT----DLPQTPLVIAISY-FITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15981 245 -LWTLMLLTDyghlSEDQLNLVTVYVFpFAHWLAFFNSSVNPIIYGYFNENFRR 297
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
47-316 2.68e-13

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 69.30  E-value: 2.68e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFT-LVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15065   9 IIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVAlLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCSTASIL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVlataESRRVAGRTYSAARAVSL--AVWGIVTLV-VLPFAV-FARLD---------DEQGRRQCVLVF 192
Cdd:cd15065  89 NLCAISLDRYIHI----KKPLKYERWMTTRRALVViaSVWILSALIsFLPIHLgWHRLSqdeikglnhASNPKPSCALDL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 193 PQPEAfwwrasrLYTLVLGFAIPVSTICVLYTTLLC--RLHAMRLDSHAKALERA--------------------KKRVT 250
Cdd:cd15065 165 NPTYA-------VVSSLISFYIPCLVMLLIYSRLYLyaRKHVVNIKSQKLPSESGskfqvpslsskhnnqgvsdhKAAVT 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 53828924 251 FLVvaILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAIsyfITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15065 238 LGI--IMGVFLICWLPFFIINIIAAFCKTCIPPKCFKI---LTWLGYFNSCLNPIIYSIFNSEFRR 298
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
48-316 2.89e-13

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 68.46  E-value: 2.89e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  48 CAVGLA---GNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINI-ADFLLRQWPFGELMCKLIVAIDQYNTFS 122
Cdd:cd15310   8 CALILAivfGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVaTLVMPWVVyLEVTGGVWNFSRICCDVFVTLDVMMCTA 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 123 SLYFLTVMSADRYLVVLATAESRRvaGRTYSAARAVSLAvwgIVTLVVLPFAVfarlddeqgrrQCVLVF-------PQP 195
Cdd:cd15310  88 SILNLCAISIDRYTAVVMPVHYQH--GTGQSSCRRVSLM---ITAVWVLAFAV-----------SCPLLFgfnttgdPTV 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 196 EAFWWRASRLYTLVLGFAIPVSTICVLYTtllcRLHAMRLdshakalerAKKRVTFLVVAILAVCLLCWTPYHLSTVvaL 275
Cdd:cd15310 152 CSISNPDFVIYSSVVSFYLPFGVTLLVYV----RIYVVLL---------REKKATQMLAIVLGAFIVCWLPFFLTHI--L 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 53828924 276 TTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15310 217 NTHCQACHVPPELYSATTWLGYVNSALNPVIYTTFNIEFRR 257
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
47-316 4.43e-13

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 67.95  E-value: 4.43e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFT-LVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15215   9 FLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTvLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFAGVN 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLataesRRVAGRTYSAARAVSLAVWGIVTLVVL----PFAVFARLDDEQGRRQCVLVfpqpeafwWR 201
Cdd:cd15215  89 TIVVVSVDRYLAII-----HPLSYPTKMTPRRGYLLIYGTWIVSVLqstpPLYGWGQAAFDERNALCSVI--------WG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 202 ASRLYTL---VLGFAIPVSTICVLYTTLLCrlhAMRLDSHAKAlerakKRVTFlvvAILAVCLLCWTPYHLSTVVALTTD 278
Cdd:cd15215 156 SSYSYTIlsvVSSFVLPVIIMLACYSMVFR---AARRCYHCKA-----AKVIF---IIIFSYVLSMGPYSFLSVLAVWVD 224
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53828924 279 LPQTPLVIAIsyfITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15215 225 TQVPQWVISI---ILWLFFLQCCIHPYIYGYMHKSIKK 259
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
54-309 5.27e-13

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 68.26  E-value: 5.27e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  54 GNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLR-QWPFGELMCKLIVAIDQYNTFSSLYFLTVMS 131
Cdd:cd15212  17 GNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLcLPFAFLTLFSRpGWLFGDRLCLANGFFNACFGIVSTLTMTLIS 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 132 ADRYLVVLATAESRrvagrtYSAARAVSL--AVWGIVTLVVLPFAVFARLDDE---QGRRQCVLVFPQPEAFWWRASRLY 206
Cdd:cd15212  97 FDRYYAIVRQPQGK------IGRRRALQLlaAAWLTALGFSLPWYLLASAPEYyekLGFYHCLYVLHSGPSRLGAAYSSV 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVLGFAIPVSTICVLYTTL--LCRLHAMR---LDSHAKALERAKKRVTFLVVAILAVCLL-CWTPYHLSTVVALTTDLP 280
Cdd:cd15212 171 LIVLCYLLPFALMCFCHYNIckTVRLSESRvrpVTTYAHLLRFYSEMRTATTVLIMIVFIIcCWGPYCLLGLVAAAGGYQ 250
                       250       260
                ....*....|....*....|....*....
gi 53828924 281 QTPLVIAISYFITslsYANSCLNPFLYAF 309
Cdd:cd15212 251 FPPLMDTVAIWMA---WANGAINPLIYAI 276
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
50-318 5.59e-13

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 67.74  E-value: 5.59e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADeLFTLVLPINIADFLLRQ--WPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15298  13 VTVVGNILVMLSIKVNRQLQTVNNYFLFSLACAD-LIIGAFSMNLYTVYIIKgyWPLGAVVCDLWLALDYVVSNASVMNL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVV-----LATAESRRVAGRTYSAARAVSLAVWGIVTLvVLPFAVFARLDDEqgrRQCVLVFPQPEAFwwra 202
Cdd:cd15298  92 LIISFDRYFCVtkpltYPARRTTKMAGLMIAAAWVLSFVLWAPAIL-FWQFVVGKRTVPD---NQCFIQFLSNPAV---- 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 sRLYTLVLGFAIPVSTICVLYTtllcrlhamrldsHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQT 282
Cdd:cd15298 164 -TFGTAIAAFYLPVVIMTVLYI-------------HISLASARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIP 229
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 53828924 283 PLVIAISYFitsLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15298 230 DTVWSIGYW---LCYVNSTINPACYALCNATFKKTF 262
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
47-315 6.58e-13

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 67.94  E-value: 6.58e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADfLLRQWPF--GELMCKLIVAIDQYNTFSS 123
Cdd:cd15133  10 IFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLgMPLELYE-LWQNYPFllGSGGCYFKTFLFETVCLAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 124 LYFLTVMSADRYLVVLATAESRRVAgrTYSAARAVSLAVWGIVTLVVLP----FAVFARLDDEQGRRQCVLVFPQpeaFW 199
Cdd:cd15133  89 ILNVTALSVERYIAVVHPLAARTCS--TRPRVTRVLGCVWGVSMLCALPntslHGIKFLGSGVPASAQCTVRKPQ---AI 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 200 WRASRLYTLVLGFAIPVSTICVLYttLLCRLHAMRLDSH---------------AKALERAKKRVTFLVVAILAVCLLCW 264
Cdd:cd15133 164 YNMIPQHTGHLFFVLPMAVISVLY--LLMALRLARERGLdatgagskigtrtgqLLQHPRTRAQVTKMLFILVVVFAICW 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 53828924 265 TPYH----LSTVVALTTDLPQT--PLVIAISYFitsLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15133 242 APFHidrlMWSFISDWTDNLHEvfQYVHIISGV---FFYLSSAVNPILYNLMSTRFR 295
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
70-316 6.93e-13

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 67.65  E-value: 6.93e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  70 TVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESR-RV 147
Cdd:cd15314  33 TPTNYLILSLAVADLLVgGLVMPPSMVRSVETCWYFGDLFCKIHSSFDITLCTASILNLCFISIDRYYAVCQPLLYRsKI 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 148 AGRTYSAARAVSLAVWGIVTLVVlpfaVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLL 227
Cdd:cd15314 113 TVRVVLVMILISWSVSALVGFGI----IFLELNIKGIYYNHVACEGGCLVFFSKVSSVVGSVFSFYIPAVIMLCIYLKIF 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 228 C-------RLHAMRLDSHAKALERAKKRVTFLVVaILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAIsyfITSLSYANS 300
Cdd:cd15314 189 LvaqrqarSIQSARTKSGASSSKMERKATKTLAI-VMGVFLLCWTPFFLCNIIDPFINYSIPPVLIEV---LNWLGYSNS 264
                       250
                ....*....|....*.
gi 53828924 301 CLNPFLYAFLDASFRR 316
Cdd:cd15314 265 TLNPFIYAFFYSWFRK 280
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
54-307 7.70e-13

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 67.97  E-value: 7.70e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  54 GNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL-VLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSA 132
Cdd:cd15957  17 GNVLVITAIAKFERLQTVTNYFITSLACADLVMGLaVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 133 DRYLVVlaTAESRRVAGRTYSAARAVSLAVWGIVTLV-VLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLG 211
Cdd:cd15957  97 DRYFAI--TSPFKYQSLLTKNKARVIILMVWIVSGLTsFLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVS 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 212 FAIPVSTICVLYTTLL--------------CRLHAMRLDSHAKALERAKKRVTFLVVA----------ILAVCLLCWTPY 267
Cdd:cd15957 175 FYVPLVIMVFVYSRVFqeakrqlqkidkseGRFHNQNIDQNGSGGGGGNRRRSKFCLKehkalktlgiIMGTFTLCWLPF 254
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 53828924 268 HLSTVVALTTD--LPQTPLViaisyFITSLSYANSCLNPFLY 307
Cdd:cd15957 255 FIVNIVHVIQDnlIRKEVYI-----LLNWIGYVNSGFNPLIY 291
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
47-325 8.18e-13

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 67.67  E-value: 8.18e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADeLFTLVLPINI--ADFLLRQWPFGELMCKLIVAIDQYNTFSSL 124
Cdd:cd15299  13 LALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACAD-LIIGVISMNLftTYIIMNRWALGNLACDLWLSIDYVASNASV 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAESRrvAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLddEQGRR-----QCVLVFPQPEAFw 199
Cdd:cd15299  92 MNLLVISFDRYFSITRPLTYR--AKRTTKRAGVMIGLAWVISFVLWAPAILFWQY--FVGKRtvppdECFIQFLSEPII- 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 200 wrasRLYTLVLGFAIPVSTICVLYttllcrlhaMRLDSHAKALERAKKRVTflvvAILAVCLLCWTPYHLSTVVALTTDL 279
Cdd:cd15299 167 ----TFGTAIAAFYLPVTIMTILY---------WRIYKETIKEKKAAQTLS----AILLAFIITWTPYNIMVLVNTFCDS 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 53828924 280 PQTPLVIAISYFitsLSYANSCLNPFLYAFLDASFRRNLRQLITCR 325
Cdd:cd15299 230 CIPKTYWNLGYW---LCYINSTVNPVCYALCNKTFRTTFKMLLLCQ 272
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
54-316 1.18e-12

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 66.77  E-value: 1.18e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  54 GNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSA 132
Cdd:cd15295  17 GNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVGAIsIPLYIPYTLTNRWDFGRGLCVFWLVIDYLLCTASVYNIVLISY 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 133 DRYLVVLATAESRRVAGRTysaARAVSL--AVWGIVTLVVLPFAVFARlDDEQGRRQCVlvfpqPEAFWWRASRLYTLVL 210
Cdd:cd15295  97 DRYQSVSNAVSYRNQQTAT---LRIVTQmvAVWVLAFLVHGPAILVSD-SWKTEDGECE-----PEFFSNWYILAITSVL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 211 GFAIPVSTICV----LYTTLLCRLHAMRLdshAKALerakkrvtflvVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVI 286
Cdd:cd15295 168 EFLVPVILVAYfntqIYWSLWKRLRDRKL---AKSL-----------AIILGTFAICWAPYSLFTIIRAACEKHRGSPWY 233
                       250       260       270
                ....*....|....*....|....*....|
gi 53828924 287 AISYFitsLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15295 234 NFAFW---LQWFNSFINPFLYPLCHKRFRK 260
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
47-315 1.26e-12

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 66.88  E-value: 1.26e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFT-LVLPINIADFLL-RQWPFGELMCKLIVAIDQYNTFSSL 124
Cdd:cd15304  10 VIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGfLVMPVSMLTILYgYRWPLPSKLCAVWIYLDVLFSTASI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAESRRVAGRTysAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQ--CVLVfpqPEAFWWRA 202
Cdd:cd15304  90 MHLCAISLDRYIAIRNPIHHSRFNSRT--KAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEgsCLLA---DENFVLIG 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 SrlytlVLGFAIPVSTICVLYTtllcrlhaMRLDSHAKALERAKKRVTFL-VVAILAVCLlcWTPYHLSTVVALTTDLPQ 281
Cdd:cd15304 165 S-----FVAFFIPLTIMVITYF--------LTIKSLQQSISNEQKASKVLgIVFFLFVVM--WCPFFITNVMAVICKESC 229
                       250       260       270
                ....*....|....*....|....*....|....*
gi 53828924 282 TPLVI-AISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15304 230 NEVVIgGLLNVFVWIGYLSSAVNPLVYTLFNKTYR 264
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
47-315 1.42e-12

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 67.19  E-value: 1.42e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADfLLRQWP--FGELMCKLIVAIDQYNTFSS 123
Cdd:cd15357  10 IFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLFgMPLEVYE-MWSNYPflFGPVGCYFKTALFETVCFAS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 124 LYFLTVMSADRYLVVLATAESRRVAGRtySAARAVSLAVWGIVTLVVLP--------FAVFARLDDEQGRRQCVLVFPqp 195
Cdd:cd15357  89 ILSVTTVSVERYVAILHPFRAKLNSTR--ERALKIIVVLWVLSVLFSIPntsihgikLQYFPNGTLIPDSATCTVVKP-- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 196 eaFW-WRASRLYTLVLGFAIPVSTICVLYTTLLCRL---HAMRLDSHAKALER-AKKRVTFLVVAILAVCLLCWTPYHL- 269
Cdd:cd15357 165 --LWiYNLIIQITSLLFYVLPMGVISVLYYLMGLKLrgdKSLEADEMNVNIQRpSRKSVTKMLFVLVLVFAICWAPFHVd 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 53828924 270 ----STVVALTTDLPQtplVIAISYFITS-LSYANSCLNPFLYAFLDASFR 315
Cdd:cd15357 243 rlffSFVVEWTEPLAN---VFNLIHVVSGvFFYLSSAVNPIIYNLLSRRFR 290
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
47-318 1.76e-12

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 66.71  E-value: 1.76e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIA-DFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15369  10 VFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLLPFKIAyHFSGNDWLFGEAMCRVVTAAFYCNMYCSIL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESrrVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDD--EQGRRQCVLVFPQPEAFWWRAS 203
Cdd:cd15369  90 LMTCISVDRFLAVVYPMQS--LSWRTLRRASFTCAAIWLLSIAGVVPLLLSEQTIQipDLGITTCHDVLNEQLLMGYYVY 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 RLYTL-VLGFAIPVSTICVLYTTLLCRLHAmrldSHAKALERAKKRVTFLVVAILAVCLLCWTPYH---LSTVVALTTDL 279
Cdd:cd15369 168 YFSIFsCLFFFVPLIITTVCYVSIIRCLSS----SSDVANSSKKTRALFMAVAVFCVFVICFGPTNvllLAHYVRFAYTS 243
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53828924 280 PQTPLVIAISYFITsLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15369 244 TNDASYFAYLLCVC-VGSISCCLDPLIYYYGSSQCQKQL 281
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
51-316 1.76e-12

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 66.36  E-value: 1.76e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  51 GLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFT-LVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15062  14 AIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSfTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSLCV 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLVVlaTAESRRVAGRTYSAARAVSLAVWgIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPeafwwrASRLYTLV 209
Cdd:cd15062  94 ISVDRYIGV--RYPLNYPTIVTARRATVALLIVW-VLSLVISIGPLLGWKEPAPADEQACGVNEEP------GYVLFSSL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 210 LGFAIPVSTICVLYttllCRLHAMrldshAKALERAKKRVTFLVVaILAVCLLCWTPYHLstVVALTTDLPQTPLVIAIS 289
Cdd:cd15062 165 GSFYLPLAIILVMY----CRVYVV-----AFKFSREKKAAKTLGI-VVGAFVLCWFPFFV--VLPLGSLFSTLKPPEPVF 232
                       250       260
                ....*....|....*....|....*..
gi 53828924 290 YFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15062 233 KVVFWLGYFNSCLNPIIYPCSSREFKR 259
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
50-318 1.80e-12

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 66.53  E-value: 1.80e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd17790  13 VTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIgAFSMNLYTTYILMGHWALGTVACDLWLALDYVASNASVMNLL 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRrvAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLddEQGRR-----QCVLVF-PQPeafwwrA 202
Cdd:cd17790  93 IISFDRYFSITRPLTYR--AKRTPRRAAIMIGLAWLISFVLWAPAILFWQY--LVGERtvlagQCYIQFlSQP------I 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 SRLYTLVLGFAIPVSTICVLYttllcrlhaMRLDSHAKALERAKKRVTflvvAILAVCLLCWTPYHLSTVVALTTDLPQT 282
Cdd:cd17790 163 ITFGTAIAAFYLPVTIMIILY---------WRIYRETIKEKKAARTLS----AILLAFILTWTPYNIMVLVSTFCKDCVP 229
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 53828924 283 PLVIAISYFitsLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd17790 230 KTLWELGYW---LCYVNSTVNPMCYALCNKSFRDTF 262
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
47-316 2.11e-12

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 66.29  E-value: 2.11e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLP--INIADFlLRQWPFGELMCKLIVAIDQYNTFSSL 124
Cdd:cd15000   9 VVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPwmFLVHDF-FQNYVLGSVGCKLEGFLEGSLLLASV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAESRrvagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGR----RQC---VLVFPqpea 197
Cdd:cd15000  88 LALCAVSYDRLTAIVLPSEAR----LTKRGAKIVIVITWIVGLLLALPLAIYRSYRERQWKnfleTYCaenTQVLP---- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 198 FWWRAsrLYTLVLGFAIPVSTICvlYTTLLCrlhamRLDSHAKALER--------AKKRVTFLVVAILAVCLLCWTPYhL 269
Cdd:cd15000 160 IYWHV--IITVLVWLPLGIMLIC--YSAIFW-----KLDKYERRVLRrehpsvvrYKKKAAKTLFIVLITFVVCRIPF-T 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 53828924 270 STVVALTTDLPQTPLVIAISYFITSLSYA-------NSCLNPFLYAFLDASFRR 316
Cdd:cd15000 230 ALIFYRYKLVPNDNTQNSVSGSFHILWFAskylmflNAAVNPLIYGFTNENFRK 283
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
47-315 2.81e-12

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 65.85  E-value: 2.81e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15213  10 MIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDIMLSLVcMPFAAVTIITGRWIFGDIFCRISAMLYWFFVLEGVA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLataesRRVAGRTYSAARAVSLAVWGIVTLVVLPFAV-FARLDDEQGRRQCVLVFPQPEAFwwRASR 204
Cdd:cd15213  90 ILLIISVDRYLIIV-----QRQDKLNPHRAKILIAVSWVLSFCVSFPPLVgWGKYEFPPRAPQCVLGYTESPAD--RIYV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTLVLGFAIPVSTICVLYttlLCRLHAMRldsHAKAleRAKKRVTFLVVailaVCLLCWTPYhlsTVVALTTDLPQ-TP 283
Cdd:cd15213 163 VLLLVAVFFIPFLIMLYSY---FCILNTVR---SFKT--RAFTTILILFI----GFSVCWLPY---TVYSLLSVFSRySS 227
                       250       260       270
                ....*....|....*....|....*....|..
gi 53828924 284 LVIAISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15213 228 SFYVISTCLLWLSYLKSAFNPVIYCWRIKKFR 259
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
47-307 3.16e-12

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 66.32  E-value: 3.16e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15058  10 IILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMgLLVVPLGATIVVTGKWQLGNFWCELWTSVDVLCVTASIE 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVlaTAESRRVAGRTYSAARAVSLAVWGIVTLV-VLPFAVFARLDDEQGRRQCvlvFPQPEAFWWRASR 204
Cdd:cd15058  90 TLCVIAVDRYIAI--TRPLRYQVLLTKRRARVIVCVVWIVSALVsFVPIMNQWWRANDPEANDC---YQDPTCCDFRTNM 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTL---VLGFAIPVSTICVLYTTLL--------------------CRLHAMRLDSHAKALERAKKRVT--------FLV 253
Cdd:cd15058 165 AYAIassVVSFYIPLLIMIFVYARVFliatrqlqlidkrrlrfqseCPAPQTTSPEGKRSSGRRPSRLTvvkehkalKTL 244
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 53828924 254 VAILAVCLLCWTPYHLSTVV-ALTTDLPQTPLVIAISYfitsLSYANSCLNPFLY 307
Cdd:cd15058 245 GIIMGTFTLCWLPFFIANIInVFNRNLPPGEVFLLLNW----LGYINSGLNPIIY 295
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
51-316 3.20e-12

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 65.68  E-value: 3.20e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  51 GLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFT-LVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15325  14 GVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTsTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSLCI 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLVVlaTAESRRVAGRTYSAARAVSLAVWgIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPeafwwrASRLYTLV 209
Cdd:cd15325  94 ISIDRYIGV--SYPLRYPSIMTERRGLLALLCVW-VLSLVISIGPLFGWKEPAPEDETICQITEEP------GYALFSAL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 210 LGFAIPVSTICVLYttllCRLHAMRLDshakaLERAKKRVTFLVVaILAVCLLCWTPYHLstVVALTTDLPQTPLVIAIS 289
Cdd:cd15325 165 GSFYLPLAIILVMY----CRVYVVALK-----FSREKKAAKTLGI-VVGCFVLCWLPFFL--VMPIGSIFPAYKPSDTVF 232
                       250       260
                ....*....|....*....|....*..
gi 53828924 290 YFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15325 233 KITFWLGYFNSCINPIIYPCSSQEFKK 259
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
47-324 3.43e-12

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 65.70  E-value: 3.43e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLR-QWPFGELMCKLIVAIDQYNTFSSL 124
Cdd:cd15305  10 IIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVgILVMPVSLIAILYDyAWPLPRYLCPIWISLDVLFSTASI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAESRRVAGRTYSAARAVslAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPeafwwrasr 204
Cdd:cd15305  90 MHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIA--AVWTISIGISMPIPVIGLQDDEKVFVNGTCVLNDE--------- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKrvtfLVVAILAVCLLCWTPYHLSTVVA-LTTDLPQTP 283
Cdd:cd15305 159 NFVLIGSFVAFFIPLIIMVITYCLTIQVLQRQQAINNERRASK----VLGIVFFLFLIMWCPFFITNILSvLCKEACDQK 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 53828924 284 LVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITC 324
Cdd:cd15305 235 LMEELLNVFVWVGYVSSGINPLVYTLFNKTYRRAFSNYIRC 275
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
50-318 4.05e-12

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 65.61  E-value: 4.05e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRmKTVTNLFILNLAIADELFTLVLPINI-ADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15150  13 VGLTMNGLAMRVFFQIPS-KSNFIIFLKNTVISDLLMILTFPFKIlSDAKLGSWPLRGFVCQVTSVIFYFTMYISILFLG 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVvlATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVF-ARLDDEQGRRQCVLVFPQPEAFWWRASRlYT 207
Cdd:cd15150  92 LITIDRYQK--TTRPFKTSNPKNLLGAKILSTVIWASMFALSLPNMILtNRQPTPKNVKKCSLLKSEFGLVWHEIVN-YI 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 LVLGFAIPVSTICVLYTtLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTV---VALTTDLPQTPL 284
Cdd:cd15150 169 CQVIFWVNFLIVIVCYT-LITKELYKSYKRTRGVGKVSRKKVNVKVFIIIAVFFICFVPFHFARIpytLSQTRDVFDCTA 247
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53828924 285 VIAISYFITS---LSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15150 248 KNTLFYVKEStlwLTSLNACLDPFIYFFLCKSFRNSL 284
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
49-317 4.12e-12

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 65.43  E-value: 4.12e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  49 AVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFlLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15165  12 VLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLLLLSLPFKMHSS-KKQWPLGRTLCSFLESLYFVNMYGSILIIV 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPfaVFARLDDEQGRRQCVLVFpqPEAFWWRASRLYTL 208
Cdd:cd15165  91 CISVDRYIAIRHPFLAKRL--RSPRKAAIVCLTIWVFVWAGSIP--IYSFHDKPTNNTRCFHGF--SNKTWSKKVIVVVE 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 209 VLGFAIPVSTICVLYTTLLCRLHAMR--LDSHAKaleraKKRVTFLVVAILAVCLLCWTPYHLSTVV---ALTTDLPQTP 283
Cdd:cd15165 165 EFGFLIPMAVMVFCSVQIIRTLLDMRrpEQPKVK-----QNKSVKIVLSNLVVFLVCFTPYHLGIFLqflVKNDIINDCS 239
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53828924 284 LVIAISYFI---TSLSYANSCLNPFLYAFLDASFRRN 317
Cdd:cd15165 240 TKQSIRLFVqvsMCLANVNCCLDAICYYFILKEFRES 276
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
55-324 4.72e-12

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 65.65  E-value: 4.72e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  55 NSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSAD 133
Cdd:cd15084  28 NGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFgSSVSFSNNIVGFFVFGKTMCEFEGFMVSLTGIVGLWSLAILAFE 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 134 RYLVVLATAESRRVAGRtYSAARAVSLAVWGIVtLVVLPFAVFARLDDEQGRRQCvlvfpQPEafWWRASR------LYT 207
Cdd:cd15084 108 RYLVICKPMGDFRFQQR-HAVSGCAFTWGWSLL-WTSPPLFGWSSYVPEGLRTSC-----GPN--WYTGGTnnnsyiLAL 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 LVLGFAIPVSTICVLYTTLLCRLHAMRLDS-HAKALERAKKRVTFLVVAILAVCLLCWTPYH-LSTVVALTTDLPQTPLV 285
Cdd:cd15084 179 FVTCFALPLSTIIFSYSNLLLTLRAVAAQQkESETTQRAEKEVTRMVIAMVMAFLICWLPYAtFAMVVATNKDVVIQPTL 258
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 53828924 286 IAI-SYFitslSYANSCLNPFLYAFLDASFRRNLRQLITC 324
Cdd:cd15084 259 ASLpSYF----SKTATVYNPIIYVFMNKQFRSCLLELLCC 294
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
54-318 1.10e-11

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 63.99  E-value: 1.10e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  54 GNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQ-WPFGELMCKLIVAIDQYNTFSSLYFLTVMS 131
Cdd:cd15302  17 GNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLEsMPFYTVYVLNGDyWPLGWVLCDLWLSVDYTVCLVSIYTVLLIT 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 132 ADRYLVVLATAESRRvaGRTYSAARAVSLAVWGIVTLV----VLPFAVFARLDDEQGRRQCVLVFPQPEAFwwrasRLYT 207
Cdd:cd15302  97 IDRYCSVKIPAKYRN--WRTPRKVLLIIAITWIIPALLffisIFGWQYFTGQGRSLPEGECYVQFMTDPYF-----NMGM 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 LVLGFAIPVSTICVLYTTLLcrlhamrldshaKALERAKK---RVTFlvvaILAVCLLCWTPYH-LSTVVALTTDLPQTP 283
Cdd:cd15302 170 YIGYYWTTLIVMLILYAGIY------------RAANRARKalrTITF----ILGAFVICWTPYHiLATIYGFCEAPPCVN 233
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 53828924 284 -LVIAISYFitsLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15302 234 eTLYTISYY---LCYMNSPINPFCYALANQQFKKTF 266
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
50-318 1.45e-11

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 63.89  E-value: 1.45e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADeLFTLVLPINI--ADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15300  13 ITIVGNVLVMISFKVNSQLKTVNNYYLLSLACAD-LIIGIFSMNLytSYILMGYWALGSLACDLWLALDYVASNASVMNL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLATAESR-----RVAGRTYSAARAVSLAVWGIVTLVVLPFAvfarlddeqGRRQCVLVFPQPEAFWWRA 202
Cdd:cd15300  92 LVISFDRYFSITRPLTYRakrtpKRAGIMIGLAWLISFILWAPPILCWQYFV---------GKRTVPERECQIQFLSEPT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 SRLYTLVLGFAIPVSTICVLYttllCRLHAMRLDshakaleraKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQT 282
Cdd:cd15300 163 ITFGTAIAAFYIPVSVMTILY----CRIYKETIK---------ERKAAQTLSAILLAFIITWTPYNIMVLVSTFCSDCIP 229
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 53828924 283 PLVIAISYFitsLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15300 230 LTLWHLGYW---LCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
52-315 2.62e-11

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 62.93  E-value: 2.62e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFT-LVLPINI-ADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15308  15 IAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLAlLVLPLYVySEFQGGVWTLSPVLCDALMTMDVMLCTASIFNLCA 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLVVLATAESRRvagRTYSAARAVSLAVWGIVTLVVLPFAVFArLDDEQGRRQCVLVFPQpeafwwRASRLYTLV 209
Cdd:cd15308  95 ISVDRFIAVSVPLNYNR---RQGSVRQLLLISATWILSFAVASPVIFG-LNNVPNRDPAVCKLED------NNYVVYSSV 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 210 LGFAIPVSTICVLYTTLLcrlhamrldsHAKALERAKKRVTFLVVAILavcLLCWTPY---HLSTVVALTTDLPqtPLVI 286
Cdd:cd15308 165 CSFFIPCPVMLVLYCAMF----------RGLGRERKAMRVLPVVVGAF---LFCWTPFfvvHITRALCESCSIP--PQLI 229
                       250       260
                ....*....|....*....|....*....
gi 53828924 287 AIsyfITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15308 230 SI---VTWLGYVNSALNPVIYTVFNAEFR 255
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
52-316 2.75e-11

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 63.28  E-value: 2.75e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFT-LVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVM 130
Cdd:cd15056  15 ILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAvLVMPFGAIELVNNRWIYGETFCLVRTSLDVLLTTASIMHLCCI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 131 SADRYLVVLATAESRRVAGRTYSAARAVSLAV------------W---GIVTLVVLPFAVfarlddeqGRRQCVLVFPQP 195
Cdd:cd15056  95 ALDRYYAICCQPLVYKMTPLRVAVMLGGCWVIptfisflpimqgWnhiGIEDLIAFNCAS--------GSTSCVFMVNKP 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 196 EAfwwrasrLYTLVLGFAIPVSTICVLYTTLLcrLHAMRLDSHAKALERAKKRVTFL----------------VVAILAV 259
Cdd:cd15056 167 FA-------IICSTVAFYIPALLMVLAYYRIY--VAAREQAHQIRSLQRAGSSNHEAdqhrnsrmrtetkaakTLGIIMG 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 260 C-LLCWTPYHLSTVVA--LTTDLPQTPLVIAIsyfitSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15056 238 CfCVCWAPFFVTNIVDpfIGYRVPYLLWTAFL-----WLGYINSGLNPFLYAFFNKSFRR 292
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
67-318 2.75e-11

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 63.27  E-value: 2.75e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  67 RMKTVTNLFILNLAIADELFTLVLPINI-ADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESR 145
Cdd:cd15969  29 RNKTSFIFYLKNIVIADLLMTLTFPFKIiQDSGLGPWNFNFFLCRYTSVLFYASMYTSIVFLGLISLDRYLKVVKPFGDS 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 146 RVAGRTYsaARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTT 225
Cdd:cd15969 109 RMYSITF--TKVLSACVWLIMAFLSLPNIILTNGQPTEDNIHDCSKLKSPLGVKWHTAVSYINICIFVAVLVILIVCYIS 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 226 LLCRLHAMRLDSHAKALERAKKRVTFLVVaiLAVCLLCWTPYHLSTV--VALTTDLPQTPLVIAISYFITS----LSYAN 299
Cdd:cd15969 187 ISRYIYKSSKQFISSSSRTRKHNQSIRVV--VAVFFVCFLPYHLCRIpfTFSQLDKILDCTIKTILYYCKEatlfLSACN 264
                       250
                ....*....|....*....
gi 53828924 300 SCLNPFLYAFLDASFRRNL 318
Cdd:cd15969 265 VCLDPIIYFFMCRSFSQRL 283
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
47-316 3.91e-11

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 62.66  E-value: 3.91e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLF---ILNLAIADELFTLV-LPINIADFLL--RQWPFGELMCKLIVAIDQYNT 120
Cdd:cd15130  10 LFVVGTVGNSVTLFTLARKKSLQSLQSTVryhLGSLALSDLLILLLaMPVELYNFIWvhHPWAFGDAGCRGYYFLRDACT 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 121 FSSLYFLTVMSADRYLVVLATAESRRVAGRtySAARAVSLAVWGIVTLVVLPFAVFA----RLDDEQ--GRRQCVLVFPQ 194
Cdd:cd15130  90 YATALNVASLSVERYLAICHPFKAKTLMSR--SRTKKFISAIWLASALLAIPMLFTMglqnESDDGThpGGLVCTPIVDT 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 195 PEAfwwRASRLYTLVLGFAIPVSTICVLYTTLlcrlhamrldshAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVV- 273
Cdd:cd15130 168 ATL---KVVIQVNTFMSFLFPMLVTSILNTVI------------ANKLVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMf 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 53828924 274 -ALTTDLPQTPLVIAISYF---ITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15130 233 cYISDEQWTTFLFDFYHYFymlTNALFYVSSAINPILYNLVSANFRQ 279
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
50-318 4.02e-11

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 62.56  E-value: 4.02e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTnLFILNLAIADELFTLVLPINI-ADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15149  13 VGILLNGVNFWIFFYVPSNKSFI-VYLKNIVFADLLMSLTFPFKIlSDVELGPWQLNVIVCRYSAVIFYLNMYVGIIFFG 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVAGRTYSaaRAVSLAVWGIVTLVVLPFAVFARLD-DEQGRRQCVLVFPQPEAFWWRASRlYT 207
Cdd:cd15149  92 LIGFDRYYKIVKPLHTSFVQNVGYS--KALSVVVWMLMAVLSVPNIILTNQSfHEANYTKCARLKSELGIQWHKASN-YI 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 LVLGFAIPVSTICVLYTTLLCRLHAMRLDShAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTV------VALTTDLPQ 281
Cdd:cd15149 169 CVSIFWVVFLLLIIFYVAISRKIYKSNQKF-RRNSTNMKAKSSRNIFSILFVFFVCFVPYHALRIpytlsqTGADYSCQS 247
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53828924 282 TPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15149 248 KTILYYMKEFTLLLSAANVCLDPIIYFFLCQPFREML 284
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
48-316 4.12e-11

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 62.48  E-value: 4.12e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  48 CAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQ-WPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15200  11 FVLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLIINLPFRIDYYLRNEvWRFGATACQVNLFMLSMNRTASIVF 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATaeSRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVfarLDDEQGRRQC----VLVFPQPEAFWWRA 202
Cdd:cd15200  91 LTAIALNRYLKVVHP--HHQLSKASVGCAAKVAAGLWILILLLNIHLLL---LDHVQSNSTClsydHGTDPSASDRWHRI 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 srLYtlVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKAleRAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQT 282
Cdd:cd15200 166 --LF--FLEFFLPLGIILFCIFSIILTLKQRKLAKQAGP--QRAVKVLAVIVLVYTVCFLPSILFALASLVAFKVSQCRS 239
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 53828924 283 PLVIAiSYFITSL--SYANSCLNPFLYAFLDASFRR 316
Cdd:cd15200 240 LDLCT-QLFHGSLafTYLNSALDPVLYCFSSPSFLN 274
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
50-307 4.54e-11

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 62.62  E-value: 4.54e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15959  13 VIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMgLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTASIETLC 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVlaTAESRRVAGRTYSAARAVSLAVWGIVTLVVLpFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTL 208
Cdd:cd15959  93 AIAVDRYLAI--TNPLRYEALVTKRRARTAVCLVWAISAAISF-LPIMNQWWRDGADEEAQRCYDNPRCCDFVTNMPYAI 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 209 V---LGFAIPVSTICVLYTTLLC----RLHAMRLD---------SHAKALERAKKRVTFLVV-----------AILAVCL 261
Cdd:cd15959 170 VsstVSFYVPLLVMIFVYVRVFVvatrQVRLIRKDkvrfppeesPPAESRPACGRRPSRLLAikehkalktlgIIMGTFT 249
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 53828924 262 LCWTPYHLSTVV-ALTTDLPQTPLVIAISYfitsLSYANSCLNPFLY 307
Cdd:cd15959 250 LCWLPFFVANIIkVFCRSLVPDPAFLFLNW----LGYANSAFNPIIY 292
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
50-318 4.99e-11

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 62.49  E-value: 4.99e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTnLFILNLAIADELFTLVLPINI-ADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15151  13 VGLILNSVAAWIFFHIPSTSTFI-VYLKNTLVADLIMTLMLPFKIlSDSGLGPWQLRAFVCRFSAVVFYITMYISIILLG 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVlaTAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVfarLDDE----QGRRQCVLVfPQPEAFWWRASR 204
Cdd:cd15151  92 LISFDRYLKI--VRPFGKSWVQRVRFAKILSGAVWLVMFLLSVPNMI---LSNKpatpISVKKCASL-KSPLGLKWHEVV 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKAlERAKKRVTFLVVAILAVCLLCWTPYHLSTV------VALTTD 278
Cdd:cd15151 166 NYICQFIFWGVFALMVLFYTIISKKVYESYKKSRSKD-NKASKKTKAKVFIIVAVFFVCFAPFHFVRVpytlsqTGKITD 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 53828924 279 LPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15151 245 CQLQNLLYIAKEITLWLAATNVCLDPLIYIFLCKSFRQRL 284
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
47-318 5.30e-11

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 62.18  E-value: 5.30e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLA----GNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL-VLPINIADFLLRQWPFGELMCKLIVAIDQYNTF 121
Cdd:cd15318   6 ACAIGMLiivlGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLtVLPFSTIRSVESCWYFGDSFCRLHTCLDTLFCL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 122 SSLYFLTVMSADRYLVV-----LATAESRRVAGRTYSAARAVSLAVwgiVTLVVLPFAVFARLDDEQGRRQCV----LVF 192
Cdd:cd15318  86 TSIFHLCFISIDRHCAIcdpllYPSKFTIRVACIFIAAGWLVPTVY---TSVFLYTKAVEEGLAELLTSVPCVgscqLLY 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 193 PQpeaFW-WRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAIlAVCLLCWTPYHLST 271
Cdd:cd15318 163 NK---LWgWLNFPVFFIPCLIMIGLYVKIFIVAKRQARAIASLLSDTNGASKRERKAAKTLGIAV-GVYLLCWLPFTIDT 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 53828924 272 VVALTTDLPQTPLVIAIsyfITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15318 239 MVDSLLNFITPPLLFDI---IIWFAYFNSACNPLIYVFSYPWFRKAL 282
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
47-314 5.68e-11

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 62.51  E-value: 5.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL--VLPINIADFLLR-QWPfgELMCKLIVAIDQYNTFSS 123
Cdd:cd15386  10 ILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALfqVLPQLIWEITYRfQGP--DLLCRAVKYLQVLSMFAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 124 LYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFpqpeAFWW--R 201
Cdd:cd15386  88 TYMLIMMTVDRYIAVCHPLRTLQQPSRQAYLMIGATWLLSCILSLPQVFIFSLREVDQGSGVLDCWADF----GFPWgaK 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 202 ASRLYTLVLGFAIPVSTICVLYtTLLC-----------------------RLHAMRLDShAKALERAKKRVTFLVVAILA 258
Cdd:cd15386 164 AYITWTTLSIFVLPVAILIVCY-SLICyeicknlkgktqtsrsegggwrtQGMPSRVSS-VRTISRAKIRTVKMTFVIVL 241
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 259 VCLLCWTPY---HLSTVVALTT-DLPQTPLVIAISYFITSLSyanSCLNPFLYAFLDASF 314
Cdd:cd15386 242 AYIACWAPFfsvQMWSVWDENApDEDSSDFAFTITMLLASLS---SCCNPWIYMFFSGHL 298
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
49-318 8.17e-11

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 61.68  E-value: 8.17e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  49 AVGLAGNSAVLYVLLRAPRMKTVTNL-FILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd14983  12 LLGLPSNLLALYAFVNRARLRLTPNViYMINLCLSDLVFILSLPIKIVEALSSAWTLPAVLCPLYNLAHFSTLYASTCFL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLATAESRRVAGRTYSAarAVSLAVWGIV-TLVVLPFAVFARLDDEQ------GRRQCVLVFPQPEAFWW 200
Cdd:cd14983  92 TAISAGRYLGVAFPIKYQLYKKPLYSC--LVCVAIWALViFHVTLVFILETSGGTLDintpvgNSSTCYENFTPEQLALL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 201 RASRLYTLVLGFAIPvsticvLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLP 280
Cdd:cd14983 170 APVRLELSLVLFFLP------LAITAFCYVRCIRILVRSRLHERRKRRAVRVAVSTLLTFVVCFGPYNISHVVGFVRHES 243
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53828924 281 QTPLVIAISYfitslSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd14983 244 VWWRKLALLT-----STCNAFLDPLIFYFLSSSMERGF 276
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
52-324 1.05e-10

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 61.39  E-value: 1.05e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL-VLPINIADFLLRQ-WPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15306  15 IGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLfVMPIALLTILFEAmWPLPLVLCPIWLFLDVLFSTASIMHLCA 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLVVLATAESRRVAGRTYSAARAVslAVWGIVTLVVLPFAVFARLDDE--QGRRQCVLvfpQPEAFwwRASRLYT 207
Cdd:cd15306  95 ISLDRYIAIKKPIQASQYNSRATAFIKIT--VVWLISIGIAIPVPIKGIETDVdnPNNITCVL---TKERF--GDFILFG 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 LVLGFAIPVSTICVLYttlLCRLHAMRldshaKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIA 287
Cdd:cd15306 168 SLAAFFTPLAIMIVTY---FLTIHALR-----KQTITNEQRASKVLGIVFFLFLLMWCPFFITNITSVLCDSCNQTTLQM 239
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53828924 288 ISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITC 324
Cdd:cd15306 240 LMEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITC 276
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
54-316 1.27e-10

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 60.82  E-value: 1.27e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  54 GNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSA 132
Cdd:cd15309  17 GNVLVCMAVSREKALQTTTNYLIVSLAVADLLVaTLVMPWVVYLEVVGEWRFSRIHCDIFVTLDVMMCTASILNLCAISI 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 133 DRYLVVLATAesrrVAGRTYSAARAVSLAvwgIVTLVVLPFAVFARL---DDEQGRRQCVLVFPqpeafwwrASRLYTLV 209
Cdd:cd15309  97 DRYTAVAMPM----LYNTRYSSKRRVTVM---ISVVWVLSFAISCPLlfgLNNTDQNECIIANP--------AFVVYSSI 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 210 LGFAIPVSTICVLYTTLLCRLHamrldshakalerAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPlviAIS 289
Cdd:cd15309 162 VSFYVPFIVTLLVYVQIYIVLQ-------------KEKKATQMLAIVLGVFIICWLPFFITHILNMHCDCNIPP---ALY 225
                       250       260
                ....*....|....*....|....*..
gi 53828924 290 YFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15309 226 SAFTWLGYVNSAVNPIIYTTFNIEFRK 252
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
52-318 1.35e-10

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 61.31  E-value: 1.35e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL-VLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVM 130
Cdd:cd15317  15 VSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLcVMPFSMIRTVETCWYFGDLFCKFHTGLDLLLCTTSIFHLCFI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 131 SADRYLVV-----LATAESRRVAGRTYSAARAVSlavwGIVTLVVLPFAVFARLDDEQGRR-----QCVLVFPQpeaFWw 200
Cdd:cd15317  95 AIDRYYAVcdplrYPSKITVQVAWRFIAIGWLVP----GIYTFGLIYTGANDEGLEEYSSEiscvgGCQLLFNK---IW- 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 201 rasrLYTLVLGFAIPVSTICVLY--------------TTLLCRLHAMRLDSHAKALERAKKRVTFLVVAIlAVCLLCWTP 266
Cdd:cd15317 167 ----VLLDFLTFFIPCLIMIGLYakiflvarrqarkiQNMEDKFRSSEENSSKASASRERKAAKTLAIVM-GIFLFCWLP 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 53828924 267 YHLSTVVALTTDLPQTPLVIAIsyfITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15317 242 YFIDTIVDEYSNFITPAIVFDA---VIWLGYFNSAFNPFIYAFFYPWFRKAF 290
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
50-309 1.58e-10

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 60.74  E-value: 1.58e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIAdFLLRQWPFGELmCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15164  13 FGLLFNVLALWVFCCKMKKWTETRVYMINLAVADCCLLFSLPFVLY-FLKHSWPDDEL-CLVLQSIYFINRYMSIYIITA 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLVVLATAESRRVagRTYSAARAVSLAVWgivtLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWwrasRLYTLV 209
Cdd:cd15164  91 IAVDRYIAIKYPLKAKSL--RSPRKAALTCGLLW----VLVIISVSLRLAWEEQEENFCFGKTSTRPSKR----TLIFSL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 210 LGFAIPVSTICVLYTTLLCRLH-AMRLDSHAkalERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPL---- 284
Cdd:cd15164 161 LGFFIPLIILSFCSIQVIRSLKkKKKTNPHE---EKLIQKAIYIVSANLIVFIVCFLPLHIGLLVRFVMESNKASCsliq 237
                       250       260
                ....*....|....*....|....*.
gi 53828924 285 VIAISYFITS-LSYANSCLNPFLYAF 309
Cdd:cd15164 238 NIRNFIYVAScLANANCCLDAICYYF 263
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
54-318 1.63e-10

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 60.72  E-value: 1.63e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  54 GNSAVLYVLLRAPRMK-TVTNLFILNLAIADELFTLVLP-INIADFLLRQ--------W---PFGELMCKLIVAidqyNT 120
Cdd:cd14980  17 GNILVIIWHISSKKKKkKVPKLLIINLAIADFLMGIYLLiIAIADQYYRGryaqyseeWlrsPPCLLACFLVSL----SS 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 121 FSSLYFLTVMSADRYLVVLATAESRRVagrTYSAARAVSLAVWGI-VTLVVLP--FAVFARLDDEQGRRQCVLVFPQPEA 197
Cdd:cd14980  93 LMSVLMMLLITLDRYICIVYPFSNKRL---SYKSAKIILILGWLFsIIFAAIPilYSINQPGDNRLYGYSSICMPSNVSN 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 198 FWWRASRLYTLVLGFAIPVsTICVLYTTLLCRLHAMRLDSHAKALERaKKRVTFLVVAILAVCLLCWTPYHlstVVALTT 277
Cdd:cd14980 170 PYYRGWLIAYLLLTFIAWI-IICILYILIFISVRKSRKSARRSSSKR-DKRIAIRLALILITDLICWLPYY---IVIFSG 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 53828924 278 DLPQTPLVIAISYFITSLSYA-NSCLNPFLYAFLDASFRRNL 318
Cdd:cd14980 245 LLTSTEIDIHVLQFIAILALPlNSAINPYLYTLTTPTFKRDF 286
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
55-316 1.88e-10

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 60.58  E-value: 1.88e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  55 NSAVLYVLLRAPRMKTVTNLFILNLAIADELFT-LVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSAD 133
Cdd:cd15333  22 NAFVIATIYLTRKLHTPANYLIASLAVTDLLVSiLVMPISIVYTVTGTWTLGQVVCDIWLSSDITCCTASILHLCVIALD 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 134 RYLVVLATAE--SRRVAGRtysAARAVSLaVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPeafwwrASRLYTLVLG 211
Cdd:cd15333 102 RYWAITDAVEysKKRTPKR---AAVMIAL-VWVISISISLPPFFWRQAKAEEEVSECVVNTDHI------LYTVYSTVGA 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 212 FAIPVSTICVLYTtllcrlhamRLDSHAKALERakkRVTFLVVAILAVCLLCWTPYHL-STVVALTTDLpqTPLVIAISY 290
Cdd:cd15333 172 FYIPTLLLIALYG---------RIYVEARARER---KATKTLGIILGAFIVCWLPFFIiSLVLPICKDA--CWFHLAIFD 237
                       250       260
                ....*....|....*....|....*.
gi 53828924 291 FITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15333 238 FFTWLGYLNSLINPIIYTMSNEDFKQ 263
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
47-315 3.27e-10

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 59.84  E-value: 3.27e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15166  10 IFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFILSLPFRMVYYAKDEWPFGDYFCRILGALTVFYPSIALWL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGR-RQCVLVFPQPEAFWWRASRL 205
Cdd:cd15166  90 LAFISADRYMAIVQPKHAKEL--KNTPKAVLACVGVWIMTLASTFPLLFLYEDPDKASNfTTCLKMLDIIHLKEVNVLNF 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLHAMRLdshAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLV 285
Cdd:cd15166 168 TRLIFFFLIPLFIMIGCYLVIIHNLVHGRT---SKLKPKVKEKSIRIIITLIVQVLVCFVPFHICFAFLMLQNGDNSYNP 244
                       250       260       270
                ....*....|....*....|....*....|
gi 53828924 286 IAIsyFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15166 245 WAA--FTTFLMNLSTCLDVILYYIVSKQFQ 272
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
52-316 7.20e-10

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 58.65  E-value: 7.20e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVM 130
Cdd:cd15296  15 VLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLVgGFCIPLYIPYVLTGRWKFGRGLCKLWLVVDYLLCTASVFNIVLI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 131 SADRYLVVLATAESRRVAGRTYSAARAVsLAVWGIVTLVVLPfavfARLDDEQGRRQCVLvfPQPEAFWWRASRLYTLVL 210
Cdd:cd15296  95 SYDRFLSVTRAVSYRAQKGMTRQAVLKM-VLVWVLAFLLYGP----AIISWEYIAGGSII--PEGECYAEFFYNWYFLMT 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 211 GFAIPVST--ICVLYTTLLCRLHAMRldsHAKALERAKKRVTFLVVaILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAI 288
Cdd:cd15296 168 ASTLEFFTpfISVTYFNLSIYLNIQK---RRFRLSRDKKVAKSLAI-IVCVFGLCWAPYTLLMIIRAACHGHCVPDYWYE 243
                       250       260
                ....*....|....*....|....*...
gi 53828924 289 SYFItsLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15296 244 TSFW--LLWVNSAINPVLYPLCHMSFRR 269
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
47-318 1.29e-09

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 58.07  E-value: 1.29e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd14972   8 LGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLASAYS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYL-VVLATAESRRVAGRTysaARAVSLAVWGI-VTLVVLPfaVFARLDDEQGRRQCVLVFPQ-PEAFwwras 203
Cdd:cd14972  88 LLAIAVDRYIsIVHGLTYVNNVTNKR---VKVLIALVWVWsVLLALLP--VLGWNCVLCDQESCSPLGPGlPKSY----- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 rLYTLVLGFAIPVSTICVLYTTLLCRLH----AMRLDSHAKALERAKKRVTFL--VVAILAVCLLCWTPyhLSTVVALTT 277
Cdd:cd14972 158 -LVLILVFFFIALVIIVFLYVRIFWCLWrhanAIAARQEAAVPAQPSTSRKLAktVVIVLGVFLVCWLP--LLILLVLDV 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 53828924 278 DLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd14972 235 LCPSVCDIQAVFYYFLVLALLNSAINPIIYAFRLKEMRRAV 275
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
50-316 1.33e-09

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 57.99  E-value: 1.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15402  13 VDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYpYPLVLTSIFHNGWNLGYLHCQISGFLMGLSVIGSIFNIT 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVagrtYSAARAVS--LAVWGIVTLVVLPFAVFARLDDEQGRRQCvlvfpqpeAFWWRASRLY 206
Cdd:cd15402  93 GIAINRYCYICHSLKYDKL----YSDKNSLCyvLLIWVLTVAAIVPNLFVGSLQYDPRIYSC--------TFAQSVSSAY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TL-VLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKR-------VTFLVVAILAVclLCWTPYH---LSTVVAL 275
Cdd:cd15402 161 TIaVVFFHFILPIIIVTFCYLRIWILVIQVRRRVKPDNKPKLKphdfrnfVTMFVVFVLFA--VCWAPLNfigLAVAVDP 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 53828924 276 TTDLPQTP-LVIAISYFitsLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15402 239 ETIVPRIPeWLFVASYY---MAYFNSCLNAIIYGLLNQNFRR 277
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
49-315 1.46e-09

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 58.32  E-value: 1.46e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  49 AVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15403  12 AIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLSLLcMPFTAVTIITVDWHFGAHFCRISAMLYWFFVLEGVAIL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLataesRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRR-QCVLVFPQpeafwWRASRLY 206
Cdd:cd15403  92 LIISVDRFLIIV-----QRQDKLNPHRAKVMIAISWVLSFCISFPSVVGWTLVEVPARApQCVLGYTE-----SPADRVY 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVLGFAIPVSTICVLYTTLLC-----RLHAMRLDSHAKAL---------------------ERAKKRVTFLVVAILAVC 260
Cdd:cd15403 162 AVLLVVAVFFVPFSIMLYSYLCilntvRRNAVRIHNHADSLclsqvsklglmglqrphqmnvDMSFKTRAFTTILILFVG 241
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 261 L-LCWTPYhlsTVVALTTDLPQT----PLVIAISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15403 242 FsLCWLPH---TVFSLLSVFSRRfyysSSFYPISTCVLWLSYLKSVFNPVIYCWRIKKFR 298
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
47-309 1.83e-09

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 57.91  E-value: 1.83e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADEL--FTLVLPINIADFLLRqWPFGELMCKLIVAIDQYNTFSSL 124
Cdd:cd15385  10 IFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVvaFFQVLPQLCWDITYR-FYGPDFLCRIVKHLQVLGMFAST 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAESRRVAGRTysaARAVSLAVWGIVTLVVLP-FAVFARLDDEQGR--RQCVLVFPQPEAFwwR 201
Cdd:cd15385  89 YMLVMMTADRYIAICHPLKTLQQPTKR---SYLMIGSAWALSFILSTPqYFIFSLSEIENGSgvYDCWANFIVPWGI--K 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 202 ASRLYTLVLGFAIPVSTICVLY--------TTLLCRLHAMRLD------------SHAKALERAKKRVTFLVVAILAVCL 261
Cdd:cd15385 164 AYITWITISIFVVPVIILLTCYgficyniwRNIKCKTRRGLSDnalknillavcvSSVKTISRAKIRTVKMTFVIVLAYI 243
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 53828924 262 LCWTPYH----LSTVVALTTDLPQTPLVIAISYFITSLsyaNSCLNPFLYAF 309
Cdd:cd15385 244 VCWAPFFtiqmWSVWDQNFPWDESENTAVTITALLASL---NSCCNPWIYMF 292
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
50-311 4.70e-09

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 56.28  E-value: 4.70e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPF-GELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd14964  11 LGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSrPQALCYLIYLLWYGANLASIWTTL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLVVLPFAVFARLD-DEQGRRQCVLVFPQPEAFWWRASRLYT 207
Cdd:cd14964  91 VLTYHRYFALCGPLKYTRL--SSPGKTRVIILGCWGVSLLLSIPPLVGKGAIpRYNTLTGSCYLICTTIYLTWGFLLVSF 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 LVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALEraKKRVTFLVVAILAVClLCWTPYHLSTVVALTTDLPQTPLVIA 287
Cdd:cd14964 169 LLPLVAFLVIFSRIVLRLRRRVRAIRSAASLNTDKN--LKATKSLLILVITFL-LCWLPFSIVFILHALVAAGQGLNLLS 245
                       250       260
                ....*....|....*....|....
gi 53828924 288 IsyFITSLSYANSCLNPFLYAFLD 311
Cdd:cd14964 246 I--LANLLAVLASTLNPFIYCLGN 267
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
52-316 4.78e-09

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 56.55  E-value: 4.78e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMKT-VTNLFILNLAIADELFT-LVLPINIADFLLRQWPFGELmCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15320  16 LLGNTLVCAAVIRFRHLRSkVTNFFVISLAVSDLLVAvLVMPWKAVAEIAGFWPFGSF-CNIWVAFDIMCSTASILNLCV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLVVLATAESRRVAgrtysAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVL---------VFPQPEAFWW 200
Cdd:cd15320  95 ISVDRYWAISSPFRYERKM-----TPKVAFIMISVAWTLSVLISFIPVQLNWHKAKPTSFLdlnaslrdlTMDNCDSSLN 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 201 RASRLYTLVLGFAIPVSTICVLYTTL-------LCRLHAM-RLDSHAK-----------------------ALERAKKRV 249
Cdd:cd15320 170 RTYAISSSLISFYIPVAIMIVTYTRIyriaqkqIRRISALeRAAVHAKncqnstgnrgsgdcqqpessfkmSFKRETKVL 249
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 250 TFLVVaILAVCLLCWTPYH-LSTVVALTTDLPQTPLVIAISYF--ITSLSYANSCLNPFLYAFlDASFRR 316
Cdd:cd15320 250 KTLSV-IMGVFVCCWLPFFiLNCMVPFCKPTSTEPFCISSTTFdvFVWFGWANSSLNPIIYAF-NADFRK 317
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
50-318 5.45e-09

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 56.38  E-value: 5.45e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLT 128
Cdd:cd15008  12 VSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVAsAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTPGVQIYVLL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 129 VMSADRYLVV---LATAESRRVAGRtysaaraVSLAVWGIVTLVVLPFAVFARLDDEqgrrQCVLVFPqPEAFWWRASRL 205
Cdd:cd15008  92 SICVDRFYTIvypLSFKVSREKAKK-------MIAASWLFDAAFVSPALFFYGSNWG----PHCNFFL-PDSWDGAAYAI 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHA-----KALERAKKRVTFLVVAILAVCLLCWTPYHlstVVAL----T 276
Cdd:cd15008 160 IHLLVGFLVPSILIILFYQKVIKYIWRIGTDGRTvrrtmNIVPRTKVKTIKMFLMLNSMFLLSWLPFY---VVQLwhprE 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 53828924 277 TDLPQTPLVIAIsyfITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15008 237 SDYRQSSLVFLA---VTWISFSSSASKPTLYSVYNANFRRGM 275
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
49-316 6.84e-09

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 56.01  E-value: 6.84e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  49 AVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15400  12 VVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYpYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFNI 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLATAESRRVAgRTYSAARAVSLaVWGIVTLVVLPFAVFARLDDEQGRRQCVlvfpqpeaFWWRASRLYT 207
Cdd:cd15400  92 TGIAINRYCYICHSFAYDKLY-SRWNTLLYVCL-IWALTVVAIVPNFFVGSLEYDPRIYSCT--------FVQTASSSYT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 L---VLGFAIPVS--TICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCL-LCWTPYH---LSTVVALTTD 278
Cdd:cd15400 162 IavvVIHFIVPITvvSFCYLRIWVLVIQVRRKVKSESKPRLKPSDFRNFLTMFVVFVIFaICWAPLNligLAVAINPQEM 241
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53828924 279 LPQTP-LVIAISYFitsLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15400 242 APKVPeWLFVVSYF---MAYFNSCLNAIIYGLLNQNFRK 277
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
47-318 7.27e-09

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 55.94  E-value: 7.27e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL--VLPINIADFLLRqWPFGELMCKLIVAIDQYNTFSSL 124
Cdd:cd15388  10 IFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFfqVLPQLVWDITDR-FRGPDVLCRLVKYLQVVGMFASS 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSlavWGIVTLVVLP-FAVFARLDDEQGRRQCVLVFPQPeafwW--R 201
Cdd:cd15388  89 YMIVAMTFDRHQAICRPMVTFQKGRARWNGPVCVA---WAISLILSLPqVFIFSKVEVAPGVYECWACFIEP----WglK 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 202 ASRLYTLVLGFAIPVSTICV-------------------LYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLL 262
Cdd:cd15388 162 AYVTWITLVVFVLPTLIITVcqvlifkeihiniylksqiIVAVVKKKQLLSSRASSVAEVSKAMIKTVKMTLVIVLVYVL 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 53828924 263 CWTPYHLSTVVALTTdlPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15388 242 CWAPFFLVQLWSVWD--PKAPTEGATFTILMLLASLNSCTNPWIYMAFSSSVSKEL 295
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
50-316 1.26e-08

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 55.30  E-value: 1.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADeLFTLV--LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15401  13 VDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVAD-LVVAVypYPLILLAIFHNGWTLGNIHCQISGFLMGLSVIGSVFNI 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLATAESRRVAGRTYSAARAVslAVWGIVTLVVLPFAVFARLDDEQGRRQCvlvfpqpeAFWWRASRLYT 207
Cdd:cd15401  92 TAIAINRYCYICHSLRYDKLYNMKKTCCYVC--LTWVLTLAAIVPNFFVGSLQYDPRIYSC--------TFAQTVSSSYT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 L---VLGFAIPVSTICVLYTTLLCRL----HAMRLDSHAKaLERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLP 280
Cdd:cd15401 162 ItvvVVHFIVPLSIVTFCYLRIWVLViqvkHRVRQDSKQK-LKANDIRNFLTMFVVFVLFAVCWGPLNFIGLAVAINPLK 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 53828924 281 QTPLV----IAISYFitsLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15401 241 VAPKIpewlFVLSYF---MAYFNSCLNAVIYGVLNQNFRK 277
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
47-316 1.39e-08

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 55.26  E-value: 1.39e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLF---ILNLAIADELFTLV-LPINIADFLLRQWP--FGELMCKLIVAIDQYNT 120
Cdd:cd15356  10 IWALGAAGNALTIHLVLKKRSLRGLQGTVhyhLVSLALSDLLILLIsVPIELYNFVWFHYPwvFGDLVCRGYYFVRDICS 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 121 FSSLYFLTVMSADRYLVVLATAESRRVAGRTYSaaRAVSLAVWGIVTLVVLPFAVF---------ARLDDEQGRRQCVL- 190
Cdd:cd15356  90 YATVLNIASLSAERYLAICQPLRAKRLLSKRRT--KWLLALIWASSLGFALPMAFImgqkyeletADGEPEPSSRVCTVl 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 191 -------VFPQPEAFwwrasrlytlvLGFAIPVSTICVLYTTLLCRLHAmrldshakaleRAKKRVTFLVVAILAVCLLC 263
Cdd:cd15356 168 vsratlkVFIQVNAF-----------VSFVLPLALIAFLNGVTVSHLRI-----------QSLQHSVQVLRAIVIAYVIC 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 53828924 264 WTPYHLSTVV--ALTTDLPQTPLVIAISYF---ITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15356 226 WLPYHARRLMfcYVPDDAWTDSLYNFYHYFymlTNTLFYVSSAVNPLLYNVVSSSFRK 283
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
47-309 1.80e-08

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 54.82  E-value: 1.80e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL--VLPINIADFLLRQWPfGELMCKLIVAIDQYNTFSSL 124
Cdd:cd15387  10 ILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfqVLPQLIWDITFRFYG-PDFLCRLVKYLQVVGMFAST 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAES-RRVAGRTYsaaravSLAVWGIVTLVVLP-FAVFARLDDEQGRRQCVLVFPQPeafwW-- 200
Cdd:cd15387  89 YMLLLMSIDRCLAICQPLRSlHRRSDRVY------VLFSWLLSLVFSIPqVHIFSLREVGNGVYDCWADFIQP----Wgp 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 201 RASRLYTLVLGFAIPVSTICVLY-----------------------TTLLCRLHAMRLDSHAKALERAKKRVTFLVVAIL 257
Cdd:cd15387 159 KAYITWITLSVYIIPVLILSVCYglisfkiwqnvklktrretktplSSAASGGAALARVSSVKLISKAKIRTVKMTFVIV 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 53828924 258 AVCLLCWTPYHLSTV-VALTTDLPQTPLVIAISYFITSLsyaNSCLNPFLYAF 309
Cdd:cd15387 239 LAYIVCWTPFFFVQMwSVWDPNAPKEASPFIIAMLLASL---NSCCNPWIYMF 288
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
55-315 1.86e-08

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 54.47  E-value: 1.86e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  55 NSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSAD 133
Cdd:cd15085  18 NVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCgTTIVTVTNYEGYFYLGDAFCIFQGFAVNYFGIVSLWSLTLLAYE 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 134 RYLVVLATAESRRVA-GRTYSAARAVSL--AVWGIVtlvvlPFAVFARLDDEQGRRQCVLVFpqPEAFWWRASRL--YTL 208
Cdd:cd15085  98 RYNVVCKPMGGLKLStKRGYQGLLFIWLfcLFWAVA-----PLFGWSSYGPEGVQTSCSIGW--EERSWSNYSYLilYFL 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 209 VLgFAIPVSTICVLYTTLLCRLHAMRLDSH---AKALERAKKRVTFLVVAILAVCLLCWTPYH-LSTVVALTTDLPQTPL 284
Cdd:cd15085 171 MC-FVIPVAIIGFSYGNVLRSLHKLNKKIEqqgGKNCPEEEERAVIMVLAMVIAFLICWLPYTvFALIVVVNPELSISPL 249
                       250       260       270
                ....*....|....*....|....*....|.
gi 53828924 285 VIAISyfiTSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15085 250 AATMP---TYFAKTSPVYNPIIYIFLNKQFR 277
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
49-316 3.06e-08

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 54.08  E-value: 3.06e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  49 AVGLAGNSAVLYVLLRAPRMKTV---TNLFILNLAIADEL-FTLVLPINIADFLL--RQWPFGELMCKLIVAIDQYNTFS 122
Cdd:cd15355  12 VVGTVGNSITLYTLARKKSLQHLqstVHYHLASLALSDLLiLLLAMPVELYNFIWvhHPWAFGDAACRGYYFLRDACTYA 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 123 SLYFLTVMSADRYLVVLATAESRRVAGRtySAARAVSLAVWGIVTLVVLPFaVFA-----RLDDEQGRRQCVLVFPQPEA 197
Cdd:cd15355  92 TALNVASLSVERYLAICHPFKAKSLMSR--SRTKKFISAIWLASALLAIPM-LFTmgeqnRSGTHPGGLICTPIVDTSTL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 198 fwwRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSH-----------------------AKALERAKKRVTFLVV 254
Cdd:cd15355 169 ---KVVIQVNAFLSFLFPMLVISVLNTLIANQLTVMVNQAEqenqvctiggqrtvlsvsmepgrVQSLRHGVLVLRAVVI 245
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 53828924 255 AIlavcLLCWTPYHLSTVV--ALTTDLPQTPLVIAISYF---ITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15355 246 AF----VVCWLPYHVRRLMfcYVSDEQWTTFLYDFYHYFymlTNVLFYVSSAINPILYNLVSANFRQ 308
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
50-315 4.82e-08

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 53.13  E-value: 4.82e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15072  13 VGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADMGISLNALVAASSSLLRRWPYGSEGCQAHGFQGFFTALASICSSAA 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLvvlataesrRVAGRTY---SAARAVSLAVWGIVTL-VVLPFAVFARLDDEQGRRQCVLVFPQPEafwwRASRL 205
Cdd:cd15072  93 IAWDRYH---------HYCTRSKlqwSTAISLVLFVWLFSAFwAAMPLLGWGEYDYEPLGTCCTLDYSKGD----RNYVS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTL---VLGFAIPVSTICVLYttllcrlHAMrldsHAKALEraKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLpqT 282
Cdd:cd15072 160 YLFtmaFFNFILPLFILLTSY-------SSI----EQKLKK--EGHLRFNTGLPLLTLLICWGPYAILALYAAITDV--T 224
                       250       260       270
                ....*....|....*....|....*....|...
gi 53828924 283 PLVIAISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15072 225 SISPKLRMVPALLAKTSPTINAILYALGNENYR 257
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
49-316 4.93e-08

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 53.24  E-value: 4.93e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  49 AVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15209  12 VVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYpYPLILHAIFHNGWTLGQLHCQASGFIMGLSVIGSIFNI 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLATAESRRVAGRTYSAARAVslAVWGIVTLVVLPFAVFARLDDEQGRRQCVlvfpqpeaFWWRASRLYT 207
Cdd:cd15209  92 TAIAINRYCYICHSLQYDRLYSLRNTCCYLC--LTWLLTVLAVLPNFFIGSLQYDPRIYSCT--------FAQTVSTVYT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 L---VLGFAIPVSTICVLYTTLLCRLHAMRldSHAKALERAKKRVT--------FLVVAILAVCllcWTPYHLSTV-VAL 275
Cdd:cd15209 162 ItvvVIHFLLPLLIVSFCYLRIWVLVLQVR--QRVKPDQRPKLKPAdvrnfltmFVVFVLFAVC---WAPLNFIGLaVAI 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 53828924 276 TTD--LPQTP-LVIAISYFItslSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15209 237 NPKemAPKIPeWLFVASYFM---AYFNSCLNAIIYGLLNQNFRK 277
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
49-315 5.91e-08

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 53.28  E-value: 5.91e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  49 AVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL--VLPINIADfLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd15076  12 IVGTPLNAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIfsVFPVFVAS-AQGYFFFGRTVCALEAFVGSLAGLVTGWS 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRVAGRtysAARAVSLAVWGIVTLVVLP-FAVFARLDDEQGRRQC------VLVFPQPEAFW 199
Cdd:cd15076  91 LAFLAFERYIVICKPFGNFRFGSK---HALGAVVATWIIGIGVSLPpFFGWSRYIPEGLQCSCgpdwytVGTKYRSEYYT 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 200 WrasrlYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKA-LERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTD 278
Cdd:cd15076 168 W-----FLFIFCFIVPLSIIIFSYSQLLGALRAVAAQQQESAsTQKAEREVSRMVVVMVGSFCLCYVPYAALAMYMVNNR 242
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53828924 279 LPQTPL-VIAISYFitsLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15076 243 DHGLDLrLVTIPAF---FSKSSCVYNPIIYCFMNKQFR 277
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
54-316 8.22e-08

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 52.94  E-value: 8.22e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  54 GNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL-VLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSA 132
Cdd:cd15316  17 GNLLVMISILHFKQLHSPTNFLIASLACADFLVGVtVMPFSTVRSVESCWYFGESFCTFHTCCDVSFCYASLFHLCFISV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 133 DRYLVVLATAesrrvagrTYSAARAVSLAVWGIVTLVVLP----FAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTL 208
Cdd:cd15316  97 DRYIAVTDPL--------VYPTKFTVSVSGICISVSWIFSltysFSVFYTGVNDDGLEELVNALNCVGGCQIILNQNWVL 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 209 V--LGFAIPVSTICVLYTT--LLCRLHAMRLDSHAKALE------------RAKKRVTFLVVAILAVcLLCWTPYHLSTV 272
Cdd:cd15316 169 VdfLLFFIPTFAMIILYGKifLVAKQQARKIEMTSSKAEsssesykdrvarRERKAAKTLGITVIAF-LVSWLPYLIDVL 247
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 53828924 273 VALTTDLPQTPLVIAISYFitsLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15316 248 IDAFMNFITPPYIYEICCW---CAYYNSAMNPLIYALFYPWFRK 288
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
47-316 8.72e-08

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 52.64  E-value: 8.72e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV---LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSs 123
Cdd:cd14968  10 IAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALaipLAILISLGLPTNFHGCLFMACLVLVLTQSSIFS- 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 124 lyfLTVMSADRYLVVLATAESRRVagRTYSAARAVSLAVWGIVTLV-VLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRA 202
Cdd:cd14968  89 ---LLAIAIDRYLAIKIPLRYKSL--VTGRRAWGAIAVCWVLSFLVgLTPMFGWNNGAPLESGCGEGGIQCLFEEVIPMD 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 SRLYTLVLGFA-IPVSTICVLYTTLLCR----------LHAMRLDSHAKALERAKKRVTFLVVAILAVcllCWTPYHLST 271
Cdd:cd14968 164 YMVYFNFFACVlVPLLIMLVIYLRIFRVirkqlrqiesLLRSRRSRSTLQKEVKAAKSLAIILFLFAL---CWLPLHIIN 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 53828924 272 VVALTTDLPQTPLViaISYFITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd14968 241 CITLFCPECKVPKI--LTYIAILLSHANSAVNPIVYAYRIRKFRQ 283
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
52-318 9.37e-08

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 52.38  E-value: 9.37e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMK-TVTNLFILNLAIADELFTLVLPINIADFLLRQ-WPFGELMCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15104  14 ITGNLLVIVALLKLIRKKdTKSNCFLLNLAIADFLVGLAIPGLATDELLSDgENTQKVLCLLRMCFVITSCAASVLSLAA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLVVlaTAESRRVAGRTYSAARAVSLAVW---GIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPeafwwrasRLY 206
Cdd:cd15104  94 IAFDRYLAL--KQPLRYKQIMTGKSAGALIAGLWlysGLIGFLPLISPQFQQTSYKGKCSFFAAFHPRV--------LLV 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVLGFAIPVSTICVLYTTLLC--RLHAMRLDSHAKALERAKKRVTFLV-------VAILAVC-LLCWTPYHLSTVVALT 276
Cdd:cd15104 164 LSCMVFFPALLLFVFCYCDILKiaRVHSRAIYKVEHALARQIHPRRTLSdfkaartVAVLIGCfLLSWLPFQITGLVQAL 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 53828924 277 TDLPQtpLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15104 244 CDECK--LYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
47-320 1.10e-07

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 52.26  E-value: 1.10e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVL-LRAPRmkTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd14973  10 LSLCGLVGNGLVLWLLgFRIKR--NPFSVYILNLAAADFLFLSCQAIQSLEDLLGGSLPGFALCRLLATLMFFSYTVGLS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAGRTYSAAraVSLAVWGIVTLVVLPFAVFarlddeqgrrqCVLVFPQPEAFWWRASRL 205
Cdd:cd14973  88 LLAAISTERCLSVLFPIWYRCHRPKHLSAV--VCALLWALSLLLSVLESYF-----------CGFLFWKFNESACRTFNF 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 206 YTLVLGFaIPVSTICVLYTTLLCRL--HAMRldshakaleRAKKRVTFLVVAILAVCLLCWTPYhlsTVVALTTDLPQTP 283
Cdd:cd14973 155 LSALLFL-LLFLVMCVSSLTLLIRVqcSSQR---------RPPTRLYVVILLTVLVFLLCGLPL---GIYWFLLLWFSNY 221
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53828924 284 LVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQ 320
Cdd:cd14973 222 LFHTFHPISDLLSCVNSSANPIIYFFVGSLRGRRLRE 258
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
52-316 1.20e-07

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 52.65  E-value: 1.20e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMKT-VTNLFILNLAIADELFT-LVLPINIADFLLRQWPFGELmCKLIVAIDQYNTFSSLYFLTV 129
Cdd:cd15319  15 LLGNILVCAAVVRFRHLRSkVTNIFIVSLAVSDLFVAlLVMPWKAVAEVAGYWPFGAF-CDVWVAFDIMCSTASILNLCV 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 130 MSADRYLVVLATAE-SRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPE----AFWWRASR 204
Cdd:cd15319  94 ISVDRYWAISSPFRyERKMTQRVALVMISVAWTLSVLISFIPVQLNWHKDSGDDWVGLHNSSISRQVEencdSSLNRTYA 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTLVLGFAIPVSTICVLYTTL--LCRLHAMRLDSHAKALERAKK----------------------RVTFLVVAILAVC 260
Cdd:cd15319 174 ISSSLISFYIPVAIMIVTYTRIyrIAQIQIRRISSLERAAEHAQScrsnridchhhtslrtsikketKVLKTLSVIMGVF 253
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 53828924 261 LLCWTPYHLSTVVALTTDLPQT------PLVIAISYFI-TSLSYANSCLNPFLYAFlDASFRR 316
Cdd:cd15319 254 VCCWLPFFILNCMVPFCDRPPAdpdaglPCVSETTFDVfVWFGWANSSLNPIIYAF-NADFRK 315
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
47-319 1.78e-07

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 51.63  E-value: 1.78e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTnLFILNLAIADELFTLVLPI----NIADFLLRQWPFGELMCKLIVaIDQYNTFS 122
Cdd:cd15110  10 ICLLGLVGNGIVLWFLGFRIRRNPFT-VYILHLAIADFTFLLCIFIlsimYIGPFNFSHSRDYVAMLIFII-LFLFGYNT 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 123 SLYFLTVMSADRYLVVLATAESRRVAGRTYSAarAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFpqpeafwwra 202
Cdd:cd15110  88 GLYLLTAISVERCLSVLYPIWYRCHRPKHQSA--IVCGLLWALSVLMTSLEYLMCIDEGFHVRNECRAVL---------- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 srLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERA--KKRVTFLVVAILAVCLLCWTPYHLSTVvaltTDLP 280
Cdd:cd15110 156 --IFIGILTFLVFTPLMLISSLILFIKVRCNSQRRHPGKLYIIimLTVIFFLIFAMPMRVLLLLNYLHHSSF----LFSN 229
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53828924 281 QTPLViaisyfitsLSYANSCLNPFLYAFLDASFRRNLR 319
Cdd:cd15110 230 PVPFL---------LSTVNSSINPIVYFLVGSLRRKRIK 259
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
47-318 3.58e-07

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 50.57  E-value: 3.58e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL-VLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15054  10 IILLTVAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMVGLvVMPPAMLNALYGRWVLARDFCPIWYAFDVMCCSASIL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAGRTysAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVF-PQPEAFWWRASR 204
Cdd:cd15054  90 NLCVISLDRYLLIISPLRYKLRMTPP--RALALILAAWTLAALASFLPIELGWHELGHERTLPNLTSgTVEGQCRLLVSL 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTLV---LGFAIPVSTICVLYTTLLcrlhamrldshaKALERAKKRVTFLVVaILAVCLLCWTPYHLSTVVALTTDLPQ 281
Cdd:cd15054 168 PYALVascLTFFLPSGAICFTYCRIL------------LAARKALKASLTLGI-LLGMFFVTWLPFFVANVVQAVCDCVS 234
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53828924 282 TPLVIAISYfitsLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15054 235 PGLFDVLTW----LGYCNSTMNPIIYPLFMRDFKRAL 267
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
47-318 4.10e-07

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 50.54  E-value: 4.10e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVL-PINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15398  10 ISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCsPFTLTCVLLDQWIFGEVMCHIVPFLQCVSVMVSTL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAGRTYsaarAVSLAVWGIVTLVVLPFAVFARLDD-------EQGRRQCVLVFPQPEAF 198
Cdd:cd15398  90 MLMSIAIVRYHMIKHPLSNHLTANHGY----FLLGTVWTLGFTICSPLPVFHKIVDlsetfnlESLKNKYLCIESWPSDS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 199 WWRASRLYTLVLGFAIPVSTICVLYTTlLCRlhamrldshakALERAKKRVTFLVVAILAVClLCWTPYHLSTVValtTD 278
Cdd:cd15398 166 YRIAFTISLLFVQYILPLVCLTVSHTS-VCR-----------SVKRSRSVFYRLTIVILAFA-VSWMPLHLFHLV---TD 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 53828924 279 LPQT-------PLVIAISYFITSLSyanSCLNPFLYAFLDASFRRNL 318
Cdd:cd15398 230 FNANlisnrhfKLVYCICHLLGMLS---CCLNPILYGFLNNGIKSDL 273
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
47-316 4.63e-07

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 50.51  E-value: 4.63e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15086  10 ILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLgTPFSFAASTQGRWLIGEHGCRWYGFANSLFGIVSLI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRrvaGRTYSAARAVSLAVWgIVTLV--VLPFAVFARLDDEQGRRQCVLVFPQPEAfwwrAS 203
Cdd:cd15086  90 SLAVLSYERYCTLLRPTEAD---VSDYRKAWLGVGGSW-LYSLLwtLPPLLGWSSYGPEGPGTTCSVQWTSRSA----NS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 RLYTLVL---GFAIPVSTICVLYTTLLCRLHAMRlDSHAKALERAKKRVTFLVVAILAVCLLCWTPYhlsTVVALTTDLP 280
Cdd:cd15086 162 ISYIICLfifCLLLPFLVMVYCYGRLLYAIKQVG-KINKSTARKREQHVLLMVVTMVICYLLCWLPY---GVMALLATFG 237
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53828924 281 QTPLVIAISYFITS-LSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15086 238 KPGLVTPVASIVPSiLAKSSTVVNPIIYVFMNKQFYR 274
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
54-316 5.87e-07

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 50.04  E-value: 5.87e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  54 GNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSA 132
Cdd:cd15312  17 GNLMVIISISHFKQLHSPTNFLILSLAITDFLLgFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMMLSTTSIFHLCFIAV 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 133 DRYLVV-----LATAESRRVAGR----TYSAARAVSLAVW-------GIVTLVVLPFAVFArlddeqgrrqCVLVFPQpe 196
Cdd:cd15312  97 DRYYAVcdplhYRTKITTPVIKVflviSWSVPCLFAFGVVfsevnleGIEDYVALVSCTGS----------CVLIFNK-- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 197 aFWwrasRLYTLVLGFAIPVSTICVLYTTL--LCRLHAMRLDS-HAKALERAKKRVTF--------LVVAILAVCLLCWT 265
Cdd:cd15312 165 -LW----GVIASLIAFFIPGTVMIGIYIKIffVARKHAKVINNrPSVTKGDSKNKLSKkkerkaakTLSIVMGVFLLCWL 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 53828924 266 PYHLSTVVALTTDLpQTPLVIAISyfITSLSYANSCLNPFLYAFLDASFRR 316
Cdd:cd15312 240 PFFVATLIDPFLNF-STPVDLFDA--LVWLGYFNSTCNPLIYGFFYPWFQK 287
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
54-315 8.17e-07

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 49.66  E-value: 8.17e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  54 GNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSA 132
Cdd:cd15331  17 GNVFVIAAILLERSLQGVSNYLILSLAVADLMVaVLVMPLSAVYEVSQHWFLGPEVCDMWISMDVLCCTASILHLVAIAL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 133 DRYLVVLATAESRRvagRTYSAARAVSLAVWGIVTLVVLPfAVFARLDDEQGRR---QCVLVFPQPEAFwwrasRLYTLV 209
Cdd:cd15331  97 DRYWAVTNIDYIRR---RTAKRILIMIAVVWFVSLIISIA-PLFGWKDEDDLDRvlkTGVCLISQDYGY-----TIFSTV 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 210 LGFAIPVSTICVLYttllcrlhamrldshAKALERAKK-RVTFLVVAILAVC-LLCWTPYHLSTVVALTTDLPQTPLVIA 287
Cdd:cd15331 168 GAFYVPLLLMIIIY---------------WKIYQAAKReRKAARTLAIITGAfVVCWLPFFLVALVMPFCGAWQISRFLE 232
                       250       260
                ....*....|....*....|....*...
gi 53828924 288 isYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15331 233 --SFFLWLGYFNSLLNPIIYTIFSPDFR 258
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
47-315 1.28e-06

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 49.07  E-value: 1.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFT-LVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15404  10 ILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLAvLNMPFALVTIITTRWIFGDAFCRVSAMFFWLFVMEGVA 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLataesRRVAGRTYSAARAVSLAVWGIVTLVVLPFAV-FARLDDEQGRRQCVLVFPQPEAFwwRASR 204
Cdd:cd15404  90 ILLIISIDRFLIIV-----QKQDKLNPYRAKVLIAVSWAVSFCVAFPLAVgSPDLQIPSRAPQCVFGYTTNPGY--QAYV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTLVLGFAIPVSTICVLYTTLLCRLHAMrldshakaleraKKRVTFLVVAILAVCLLCWTPYHLSTVVA-LTTDLPQTP 283
Cdd:cd15404 163 ILIMLIFFFIPFMVMLYSFMGILNTVRSF------------KTRAFTTILILFIVFTVCWAPFTTYSLVAtFNSHFYHKH 230
                       250       260       270
                ....*....|....*....|....*....|..
gi 53828924 284 LVIAISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15404 231 NFFEISTWLLWLCYLKSALNPLIYYWRIKKFR 262
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
55-314 1.86e-06

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 48.41  E-value: 1.86e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  55 NSAVLYVLLRAPRMKTVTNLFILNLAIADELFT-LVLPINIADFLL-RQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSA 132
Cdd:cd15328  18 NLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAaLVMPLSLVHELSgRRWQLGRSLCQVWISFDVLCCTASIWNVTAIAL 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 133 DRYLVVLATAE-SRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQcvlVFPQPeafwwrASRLYTLVLG 211
Cdd:cd15328  98 DRYWSITRHLEyTLRTRRRISNVMIALTWALSAVISLAPLLFGWGETYSEDSEECQ---VSQEP------SYTVFSTFGA 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 212 FAIPVSTICVLYTTLLcrlhamrldshaKALERaKKRVTFLVVAILAVCLLCWTPYHLSTVVA--LTTDLPQtplvIAIS 289
Cdd:cd15328 169 FYLPLCVVLFVYWKIY------------KAAQK-EKRAALMVGILIGVFVLCWIPFFLTELISplCSCDIPP----IWKS 231
                       250       260
                ....*....|....*....|....*
gi 53828924 290 YFITsLSYANSCLNPFLYAFLDASF 314
Cdd:cd15328 232 IFLW-LGYSNSFFNPLIYTAFNKNY 255
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
47-172 2.20e-06

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 48.61  E-value: 2.20e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADflLRQ---WPFGELMCKLIVAIDQYNTFS 122
Cdd:cd15005  10 ILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLAcFPFVMAS--VRHgsgWIYGALSCKVIAFLAVLFCFH 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 53828924 123 SLYFLTVMSADRYLVVlatAESRRVAGR-TYSAARAVSLAVWGIVTLVVLP 172
Cdd:cd15005  88 SAFTLFCIAVTRYMAI---AHHRFYAKRmTFWTCLAVICMAWTLSVAMAFP 135
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
50-315 3.17e-06

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 47.90  E-value: 3.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADEL-----FTLVLPINIADFLLrqwpFGELMCKLIVAIDQYNTFSSL 124
Cdd:cd15080  13 LGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFmvfggFTTTMYTSMHGYFV----FGPTGCNLEGFFATLGGEIAL 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAESRRVAgrTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVF--PQPEAFWwRA 202
Cdd:cd15080  89 WSLVVLAIERYVVVCKPMSNFRFG--ENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYytLKPEVNN-ES 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 203 SRLYTLVLGFAIPVSTICVLYTTLLCRL-HAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPY-HLSTVVALTTDLP 280
Cdd:cd15080 166 FVIYMFVVHFTIPLIVIFFCYGRLVCTVkEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVPYaSVAFYIFTHQGSD 245
                       250       260       270
                ....*....|....*....|....*....|....*
gi 53828924 281 QTPLVIAISYFITSLSyanSCLNPFLYAFLDASFR 315
Cdd:cd15080 246 FGPIFMTIPAFFAKSS---AVYNPVIYILMNKQFR 277
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
212-316 4.76e-06

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 47.46  E-value: 4.76e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 212 FAIPVSTICVLYTTLLCRLHA----MRLDSHAKAleRAKKRVTFLVVAILAVCLLCWTPYH-LSTVVALTTDLPQTPLVI 286
Cdd:cd15075 173 FAIPFAIILVSYGYLLWTLRQvaklGVAEGGSTA--KAEVQVARMVVVMVMAFLLCWLPYAaFALTVVSKPDVYINPLIA 250
                        90       100       110
                ....*....|....*....|....*....|
gi 53828924 287 AISYFITSLSyanSCLNPFLYAFLDASFRR 316
Cdd:cd15075 251 TVPMYLAKSS---TVYNPIIYIFMNKQFRD 277
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
47-176 5.64e-06

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 47.10  E-value: 5.64e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRmKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYF 126
Cdd:cd14994  11 VLIGGVIGVILMSFLLVKMNT-RSVTTTAVINLIVVHSLFLLTVPFRIYYYASKTWKFGMPLCKMVSAMIHIHMHLTFLF 89
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 53828924 127 LTVMSADRYLVVLATAESRRVAGRTYsaARAVSLAVWGIVTLVVLPFAVF 176
Cdd:cd14994  90 YVIILVIRYLIFFQRKDKMEFYRKLH--AVAASAVVWVLVLLIVVPVFVK 137
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
49-315 6.52e-06

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 47.13  E-value: 6.52e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  49 AVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15077  12 IAGFPINVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCFgSTTAFYSFSQMYFVLGPLACKIEGFTATLGGMVSLWSL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLATAESRRVAGrTYSAARAVSLAVWGIVTlVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASR-LY 206
Cdd:cd15077  92 AVVAFERFLVICKPLGNFTFRG-THAIIGCIATWVFGLAA-SLPPLFGWSRYIPEGLQCSCGPDWYTTNNKWNNESYvMF 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVLGFAIPVSTICVLYTTLLCRLHAM-RLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDlpQTPLV 285
Cdd:cd15077 170 LFCFCFGVPLSIIVFSYGRLLLTLRAVaKQQEQSASTQKAEREVTKMVVVMVLGFLVCWLPYASFALWVVTNR--GEPFD 247
                       250       260       270
                ....*....|....*....|....*....|
gi 53828924 286 IAISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15077 248 LRLASIPSVFSKASTVYNPVIYVFMNKQFR 277
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
48-315 1.11e-05

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 46.31  E-value: 1.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  48 CAVGLA---GNSAVLYVLLRAPRMKTVTNLFILNLAIAD-ELFTLVLPINIADFLLRQWPFGE--LMCKLIVAIdqynTF 121
Cdd:cd15070   8 ILIGLCavvGNVLVIWVVKLNPSLRTTTFYFIVSLALADiAVGVLVIPLAIVVSLGVTIHFYSclFMSCLLVVF----TH 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 122 SSLYFLTVMSADRYLVVLATAESRRVagrtySAARAVSLAV---WGIVTLVVL---------PFAVFARLDDEQGRRQCV 189
Cdd:cd15070  84 ASIMSLLAIAVDRYLRVKLTVRYRIV-----TTQRRIWLALglcWLVSFLVGLtpmfgwnrkPSLESVNTTPLQCQFTSV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 190 LVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVcllCWTPYH- 268
Cdd:cd15070 159 MRMDYMVYFSFFTWILIPLVIMCALYVDIFYIIRNKLSQNATGFRETGAFYGREFKTAKSLALVLFLFAV---CWLPLSi 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 53828924 269 LSTVVALTTDLPQTPLVIAIsyfitSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15070 236 INCVVYFNPKVPKIALYLGI-----LLSHANSMMNPIVYACKIKKFK 277
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
47-318 1.30e-05

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 45.98  E-value: 1.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15078  10 IGFLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLgVTFTFMSCVRGRWVFDVAGCVWDGFSNSLFGIVSIM 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYL-VVLATAESRRVAGRTYSAARAVSLAVWGivtlvvLPFAVFARLDDEQGRRQCVLVFPQPEAFwwRASR 204
Cdd:cd15078  90 TLTVLAYERYIrVVHAKVVNFSWSWRAITYIWLYSLAWTG------APLLGWNRYTLEVHGLGCSFDWKSKDPN--DTSF 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYTLVLG-FAIPVSTICVLYTTLLCRLHAMRL-----DSHAKALERAKKRVTFLVVAILAVCLLCWTPYH-LSTVVALTT 277
Cdd:cd15078 162 VLLFFLGcLVVPLGIMAYCYGHILYEIRMLRSvedlqTFQVIKILKYEKKVAKMCLLMISTFLICWMPYAvVSLLVTSGY 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 53828924 278 DLPQTPLVIAISYFitsLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15078 242 SKLVTPTIAIIPSL---FAKSSTAYNPVIYIFMIRKFRQCL 279
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
48-322 1.42e-05

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 46.08  E-value: 1.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  48 CAVGLAGNSAVLYVLLRAPR--MKTVTNLFILNLAIADELFTLVL-PINIADFLL-RQWPFGELMCklivaidQYNTF-- 121
Cdd:cd14981  11 FVFGVLGNLLALIVLARSSKshKWSVFYRLVAGLAITDLLGILLTsPVVLAVYASnFEWDGGQPLC-------DYFGFmm 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 122 -----SSLYFLTVMSADRYLVVLATAESRRVAGRtySAARAVSLAVWgIVTLVV--LPFAVFARLDDEQGRRQCVLVF-- 192
Cdd:cd14981  84 sffglSSLLIVCAMAVERFLAITHPFFYNSHVKK--RRARLMLGAVW-AFALLIasLPLLGLGSYVLQYPGTWCFLDFys 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 193 --PQPEAFwwraSRLYTLVLGFAIPVSTIC---VLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVV---AILAVCLLCW 264
Cdd:cd14981 161 knTGDAAY----AYLYSILGLLILLVTLLCnllVIITLLRMRRRKKRHRRSRRSARRQKRNEIQMVVlllAITVVFSVCW 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 53828924 265 TPYhlsTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFldasFRR-NLRQLI 322
Cdd:cd14981 237 LPL---MIRVLINATGDSEKNGKTDLLAVRMASWNQILDPWVYIL----LRKeVLRRLY 288
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
54-318 1.73e-05

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 45.70  E-value: 1.73e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  54 GNSAVLYVLLRAPRMKTVTNLFILNLAIADELFT-LVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSA 132
Cdd:cd15214  16 GNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSvLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGAIAI 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 133 DRYLVVLATAesrrVAGRTYSAARAVSLAVWGIVTLVV---LPFAVFARLDDEQGRRQCVLVF---PQPEAFWWRASRLY 206
Cdd:cd15214  96 DRYYAVLYPM----VYPMKITGNRAVLALVYIWLHSLIgclPPLFGWSSLEFDRFKWMCVAAWhkeAGYTAFWQVWCALL 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 207 TLVlgfaipVSTICVLYTTLLCRlhamrlDSHAKALerakkrVTFLVVaiLAVCLLCWTPYHLstVVALTTDLPQTPLVI 286
Cdd:cd15214 172 PFV------VMLVCYGFIFRVAR------ANQCKAF------ITILVV--LGAFVTTWGPYMV--VISTEALWGKNSVSP 229
                       250       260       270
                ....*....|....*....|....*....|..
gi 53828924 287 AISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15214 230 QLETLATWLSFTSAVCHPLIYGLWNKTVRKEL 261
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
47-315 2.41e-05

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 45.31  E-value: 2.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIAD---ELFTLVLPINIA-DFLLRQWPFGELMCKLIVAidqynTFS 122
Cdd:cd15069  10 IAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADvavGLFAIPFAITISlGFCTDFHSCLFLACFVLVL-----TQS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 123 SLYFLTVMSADRYLVVLATAESRRVAgrTYSAARAVSLAVWGIVTLVVL-PFAVFARLD----------DEQGRRQCVLV 191
Cdd:cd15069  85 SIFSLLAVAVDRYLAIKVPLRYKSLV--TGKRARGVIAVLWVLAFGIGLtPFLGWNKAMsatnnstnpaDHGTNHSCCLI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 192 FPQPEAFWWRASRLYTLVLGFAI-PVSTICVLYTTLL---CR-LHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTP 266
Cdd:cd15069 163 SCLFENVVPMSYMVYFNFFGCVLpPLLIMLVIYIKIFlvaCRqLQRTELMDHSRTTLQREIHAAKSLAIIVGIFALCWLP 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 53828924 267 YHLSTVVAL-----TTDLPQTPLVIAISyfitsLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15069 243 VHILNCITLfqpefSKSKPKWAMNVAIL-----LSHANSVVNPIVYAYRNRDFR 291
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
47-318 3.62e-05

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 44.51  E-value: 3.62e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL-VLPINIADFLLR--------QWPFGeLMCKLIVAIDQ 117
Cdd:cd15136  10 VFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIyLGLLAIVDAKTLgeyynyaiDWQTG-AGCKTAGFLAV 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 118 YNTFSSLYFLTVMSADR-YLVVLATAESRRVAGRTysaARAVSLAVWGI-VTLVVLP---------FAVFARLDDEQgrr 186
Cdd:cd15136  89 FSSELSVFTLTVITLERwYAITHAMHLNKRLSLRQ---AAIIMLGGWIFaLIMALLPlvgvssyskTSICLPFETET--- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 187 qcvlvfpqpeafwwRASRLY--TLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALeRAKKRVTFLVVAILavclLCW 264
Cdd:cd15136 163 --------------PVSKAYviFLLLFNGLAFLIICGCYIKIYLSVRGSGRAANSNDT-RIAKRMALLVFTDF----LCW 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 53828924 265 TPYhlsTVVALTTDLPQTPLVIAISYFITSLSYA-NSCLNPFLYAFLDASFRRNL 318
Cdd:cd15136 224 API---AFFGLTAAFGLPLISVSNAKILLVFFYPlNSCANPFLYAIFTKQFRRDC 275
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
55-315 4.49e-05

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 44.51  E-value: 4.49e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  55 NSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLP-INIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSAD 133
Cdd:cd15081  30 NGLVLVATLKFKKLRHPLNWILVNLAIADLGETVIAStISVVNQIFGYFILGHPMCVLEGFTVSVCGITGLWSLTIISWE 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 134 RYLVVLATAESRRVAGRTYSAARAVSLaVWGIVtLVVLPFAVFARLDDEQGRRQC-VLVFPQPEAFWWRASRLYTLVLGF 212
Cdd:cd15081 110 RWVVVCKPFGNIKFDGKLAIVGIIFSW-VWSAV-WCAPPIFGWSRYWPHGLKTSCgPDVFSGSSDPGVQSYMIVLMITCC 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 213 AIPVSTICVLYTTLLCRLHAM-RLDSHAKALERAKKRVTFLVVAILAVCLLCWTPY-HLSTVVALTTDLPQTPLVIAI-S 289
Cdd:cd15081 188 IIPLAIIILCYLQVWLAIRAVaQQQKESESTQKAEKEVSRMVVVMIFAYCFCWGPYtFFACFAAANPGYAFHPLAAALpA 267
                       250       260
                ....*....|....*....|....*.
gi 53828924 290 YFITSLsyanSCLNPFLYAFLDASFR 315
Cdd:cd15081 268 YFAKSA----TIYNPIIYVFMNRQFR 289
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
47-322 5.75e-05

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 44.42  E-value: 5.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924   47 ICAVGLAGNSAVLYVLLRAPRMKTVTN--LFILNLAIADELFTLVLPINIadfLLRQWPFGE--LMCKLIVAIdqYNTFS 122
Cdd:PHA03235  42 IISVGGPLNLIVLVTQLLANRVHGFSTptLYMTNLYLANLLTVFVLPFIM---LSNQGLLSGsvAGCKFASLL--YYASC 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  123 SLYFLTVM--SADRYLVVLATAESRRvagRTYSAARAVSLAVWGIVTLVVLPFAVFARL---DD----EQGRRQCVLVFp 193
Cdd:PHA03235 117 TVGFATVAliAADRYRVIHQRTRARS---SAYRSTYKILGLTWFASLICSGPAPVYTTVvahDDvdpeAPGYETCVIYF- 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  194 qpeafwwRASRLYTLVLGF---------AIPVSTICVLYTTLLCRLhamrldshaKALERAKKRVTFLVVAILAVCLLCW 264
Cdd:PHA03235 193 -------RADQVKTVLSTFkvlltlvwgIAPVVMMTWFYTFFYRTL---------KRASYKKRSRTLTFVCILLLSFLCL 256
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 53828924  265 -TPYHL------STVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLI 322
Cdd:PHA03235 257 qTPFVAimifdsYATLIWPSDCEHINLRDAVSTLSRLVPNLHCLLNPILYAFLGNDFLKRFRQCF 321
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
47-318 7.93e-05

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 43.63  E-value: 7.93e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVL-PINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15082  23 VTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGgTISFLTNARGYFFLGVWACVLEGFAVTFFGIVALW 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAGRtySAARAVsLAVWGIVTLVVLPFAV-FARLDDEQGRRQCvlvfpqpEAFWWRAS- 203
Cdd:cd15082 103 SLAVLAFERFFVICRPLGNIRLQGK--HAALGL-LFVWTFSFIWTIPPVLgWSSYTVSKIGTTC-------EPNWYSGNm 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 RLYTLVLGF-----AIPVSTICVLYTTLLCRLHAMRlDSHAK--ALERAKKRVTFLVVAILAVCLLCWTPYH-LSTVVAL 275
Cdd:cd15082 173 HDHTYIITFfttcfILPLGVIFVSYGKLLQKLRKVS-NTQGRlgNARKPERQVTRMVVVMIVAFMVCWTPYAaFSILVTA 251
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 53828924 276 TTDLPQTPLVIAISYFitsLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15082 252 HPTIHLDPRLAAIPAF---FSKTAAVYNPIIYVFMNKQFRKCL 291
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
49-318 2.21e-04

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 42.49  E-value: 2.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  49 AVGLAGNSAVLYVLLRAPRMKTVTNLFIL--NLAIADELFT-LVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15142  12 IFGVVGNLIAIVVLCKSRKEQKETTFYTLvcGLAVTDLLGTcLASPVTIATYLKGRWPGGQPLCEYFSFILLFFSLSGLS 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVV-----LATAESRRVAGRTYSAARAVSlavwgiVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWW 200
Cdd:cd15142  92 IICAMSIERYLAInhayfYNHYVDKRLAGLTLFAIYASN------ILFCALPSMGLGKSKLQYPKTWCFIDWRTNVSVHA 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 201 RASRLYTLVLGFAIPVSTIC-VLYTTLLCRLHAMRL-------DSHAKALER---------AKKRVTFLVVAILAVCLLC 263
Cdd:cd15142 166 AYSYMYAGFSSLLILVTVLCnVLVCGALIRMHRQFVrrtslgtDQRLSDFRRrrsfrrmagAEIQMVILLIATSVVVLIC 245
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 53828924 264 WTPYhlsTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15142 246 SIPL---VVRVFVNQLYQPAVEKDLDKNPDLQAIRIASVNPILDPWIYILLRKTV 297
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
47-318 4.41e-04

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 41.29  E-value: 4.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKT-VTNLFILNLAIADELFTLV-LPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSL 124
Cdd:cd15219   9 VLVVSLLSNLLVLLCFLYSAELRKqVPGIFLLNLSFCNLLLTVLnMPFTLLGVVRNRQPFGDGFCQAVGFLETFLTSNAM 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAeSRRVAGRTYSAARAVSLAvWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQ-PEAFWWRAS 203
Cdd:cd15219  89 LSMAALSIDRWIAVVFPL-SYTSKMRYRDAALMVGYS-WLHSLTFSLVALFLSWLGYSSLYASCTLHLPReEERRRFAVF 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 204 RLYTLVLGFAIPVSTICVLYTTLLcrlhamrldsHAKALERAKKRVTFLVvailAVCLLCWTPYHLSTVVALttdLPQTP 283
Cdd:cd15219 167 TAFFHAFTFLLSLLVLCVTYLKVL----------KVRRRQRATKKISIFI----GTFVLCFAPYVITRLVEL---LPFVT 229
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53828924 284 lvIAISYFITS--LSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15219 230 --INRYWGIVSkcLTYSKAASDPFVYSLLRQQYRKVL 264
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
55-318 5.72e-04

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 40.98  E-value: 5.72e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  55 NSAVLYVLLRAPRM-KTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSAD 133
Cdd:cd15341  18 NVAVLYLILSSPKLrRKPSYLFIGSLALADFLASVVFACSFVDFHVFHGVDSSAIFLLKLGGVTMSFTASLGSLLLMAFD 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 134 RYLVVLATAESRRVAGRtysaARA-VSLAVWGIVTLVV--LPFavfarlddeQGRRQCVLVFPQPEAFWWRASR-LYTLV 209
Cdd:cd15341  98 RYVCIYYPSEYKALVTR----KRAlVALAVMWVLTALIayLPL---------MGWNCCPLNSPCSELFPLIPNDyLLSWL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 210 LGFAIPVSTICVLYTTLLCRLH------AMRLDSHAKALERAKKRVTF--LVVAILAVCLLCWTPYHLSTVVALTTDLpq 281
Cdd:cd15341 165 LLVAILLSGIIYTYGHVLWKAHkhvvymEKHQDQQGPGNARMRLDVRLakTLGLVLAVLLICWSPVLALMMHSLFTSL-- 242
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 53828924 282 TPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15341 243 SDHIKKAFAFCSTLCLVNSMVNPIIYALRSRELRSSL 279
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
55-318 6.49e-04

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 40.78  E-value: 6.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  55 NSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPIN-IADFLLRQWPFGELMCKLIVAidqynTFS-SLYFLTVMSA 132
Cdd:cd15961  18 NAIVVLIIFQNPSLRAPMFLLIGSLALADLLAGIGLILNfIFAYLLQSEAAKLVTVGLIVA-----SFSaSVCSLLAITV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 133 DRYLVVL--ATAESRRVAGRTYSaaraVSLAVWGI-VTLVVLPFAVFARLDDEQgrrQCVLVFPQPEAFwwRASRLYTLV 209
Cdd:cd15961  93 DRYLSLYyaLTYNSERTVTFTYV----MLVLLWGAsICLGLLPVMGWNCLADES---TCSVVRPLTKNN--AAILSVSFL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 210 LGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALER---AKKRVTFLVVaILAVCLLCWTPYhlsTVVALTTDLPQTPLVi 286
Cdd:cd15961 164 LMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHyvtTRKGVSTLAI-ILGTFAACWMPF---TLYSLIADYTYPSIY- 238
                       250       260       270
                ....*....|....*....|....*....|..
gi 53828924 287 aiSYFITSLSYANSCLNPFLYAFLDASFRRNL 318
Cdd:cd15961 239 --TYATLLPATYNSIINPVIYAFRNQEIQKAL 268
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
55-315 8.71e-04

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 40.59  E-value: 8.71e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  55 NSAVLYVLLRAPRMKTVTN-LFILNLAIADELFTLVLPINIADF-LLRQWPFGELMCKLIVAIDQYNTfSSLYFLTVMSA 132
Cdd:cd15099  18 NILVLLTILSSTALRRRPSyLFIGSLALADMLASVIFTISFLDFhVFHQRDSRNLFLFKLGGVTMAFT-ASVGSLLLTAL 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 133 DRYLVVLATAESRRVAGRTysAARAVSLAVWGIVtlVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGF 212
Cdd:cd15099  97 DRYLCIYQPSNYKLLVTRT--RAKVAILLMWCVT--IIISFLPLMGWRCKTWDSPCSRLFPYIDRHYLASWTGLQLVLLF 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 213 AIPVSTICVLYTTllcRLHAMRLDSH--------AKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLpqTPL 284
Cdd:cd15099 173 LIIYAYPYILWKA---HRHEANMGGPklgrqqvkGQARMRMDIRLAKTLSLILLVLAICWLPVLAFMLVDVRVTL--TNK 247
                       250       260       270
                ....*....|....*....|....*....|.
gi 53828924 285 VIAISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15099 248 QKRMFAFCSMLCLVNSCVNPIIYALRSRELR 278
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
47-315 9.74e-04

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 40.31  E-value: 9.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELF-TLVLPINIAdfLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15068  10 IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVgVLAIPFAIT--ISTGFCAACHGCLFIACFVLVLTQSSIF 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVV-LATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASR 204
Cdd:cd15068  88 SLLAIAIDRYIAIrIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVP 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 L-YTLVLGF----AIPVSTICVLYTTLL--CRLHAMRLDSHAKALERAKKRVTFLVVA------ILAVCLLCWTPYHLST 271
Cdd:cd15068 168 MnYMVYFNFfacvLVPLLLMLGVYLRIFlaARRQLKQMESQPLPGERARSTLQKEVHAakslaiIVGLFALCWLPLHIIN 247
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 53828924 272 VVAL-TTDLPQTPLVIAisYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15068 248 CFTFfCPDCSHAPLWLM--YLAIVLSHTNSVVNPFIYAYRIREFR 290
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
47-315 1.38e-03

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 39.83  E-value: 1.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIAD-ELFTLVLPINIADFLLRQWPFgeLMCKLIVAIDQYNTFSSLY 125
Cdd:cd15071  10 IALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADvAVGALVIPLAIIINIGPQTEF--YSCLMVACPVLILTQSSIL 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 126 FLTVMSADRYLVVLATAESRRVAgrtysAARAVSLAVWG--IVTLVV--LPFAVFARLDDEQGRRQCVLVFPQPE---AF 198
Cdd:cd15071  88 ALLAIAVDRYLRVKIPTRYKSVV-----TPRRAAVAIAGcwILSFLVglTPMFGWNNLNAVERAWAANSSMGELVikcQF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 199 WWRASRLYTLVLGFAI----PVSTICVLYTTLLCRLHAMRLDSHAKALERAKK------RVTFLVVAILAVCLLCWTPYH 268
Cdd:cd15071 163 ETVISMEYMVYFNFFVwvlpPLLLMLLIYLEVFYLIRKQLNKKVSSSSSDPQKyygkelKIAKSLALILFLFALSWLPLH 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 53828924 269 LSTVVALTTDLPQTPLVIaiSYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15071 243 ILNCITLFCPSCKKPMIL--TYIAIFLTHGNSAMNPIVYAFRIKKFR 287
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
55-309 1.80e-03

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 39.48  E-value: 1.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  55 NSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVmsaDR 134
Cdd:cd15963  18 NAIVVAVIFYTPAFRAPMFLLIGSLATADLLAGLGLILHFAFVYCIQSAPVNLVTVGLLAPSFTASVSSLLAITI---DR 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 135 YLVVL--ATAESRRVAGRTYsaarAVSLAVWGI-VTLVVLPFAVFARLDDEQgrrQCVLVFPQPEAFWWRASRLYTLVLG 211
Cdd:cd15963  95 YLSLYnaLTYYSERTVTRTY----IMLILTWGAsLCLGLLPVVGWNCLKDPS---TCSVVKPLTKNHLVILSISFFMVFA 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 212 FAIpvsTICVLYTTLLCRlHAMRLDSHAKALERAKKRVTFLVVAILAVCL----LCWTPYhlsTVVALTTDLPQTPLVia 287
Cdd:cd15963 168 LML---QLYAQICRIVCR-HAHQIALQRHFLPTSHYVTTRKGIATLAVILgtfaSCWLPF---AVYCLLGDYTYPALY-- 238
                       250       260
                ....*....|....*....|..
gi 53828924 288 iSYFITSLSYANSCLNPFLYAF 309
Cdd:cd15963 239 -TYATLLPATYNSMINPIIYAF 259
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
50-318 1.86e-03

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 39.50  E-value: 1.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  50 VGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL-VLPINIADFLLRQWPFGELM-------CKLIVAIDQYNTF 121
Cdd:cd15964  13 LAILGNVFVLLILLTSHYKLTVPRFLMCNLAFADFCMGIyLLLIASVDLHTRSEYYNHAIdwqtgpgCNTAGFFTVFASE 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 122 SSLYFLTVMSADR-YLVVLATAESRRVAGRtysaaRAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVfpQPEAFWW 200
Cdd:cd15964  93 LSVYTLTVITLERwYAITFAMRLDRKIRLR-----HASAIMLGGWVFCFLLALLPLVGVSSYAKVSICLPM--DTETPLA 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 201 RASRLYTLVLGFaIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAilavcLLCWTPYhlsTVVALTTDLP 280
Cdd:cd15964 166 QAYIVFVLMLNI-IAFVIICACYIKIYITVRNPQYKSGDKDTKIAKRMAVLIFTD-----FICMAPI---SFYALSAILN 236
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 53828924 281 QTPLVIAISYFITSLSYA-NSCLNPFLYAFLDASFRRNL 318
Cdd:cd15964 237 KPLITVSNSKILLVLFYPlNSCANPFLYAIFTKAFRRDV 275
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
47-135 2.47e-03

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 39.07  E-value: 2.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFT-LVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLY 125
Cdd:cd15127  10 IFGIGIMGNVAVMCIVCHNYYMRSISNSLLANLAFWDFLIIfFCLPLVIFHELTKKWLLGDFSCKIVPYIEVASLGVTTF 89
                        90
                ....*....|
gi 53828924 126 FLTVMSADRY 135
Cdd:cd15127  90 TLCALCIDRF 99
7tmA_MrgprD cd15108
mas-related G protein-coupled receptor subtype D, member of the class A family of ...
48-320 2.57e-03

mas-related G protein-coupled receptor subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320236  Cd Length: 276  Bit Score: 38.97  E-value: 2.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  48 CAVGLAGNSAVLYvLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15108  11 CVCGMAGNGLVVW-LLSCRGRRTPFCVYVLHLAVADLLFLLCMASTLSLETSPLVITHDLAYEVVRRVKYFAYTASLSLL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLATAESRRVAGRTYSAarAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVfpqpeafwwrASRLYT 207
Cdd:cd15108  90 TAISTQRCLSVLFPIWYKCHQPRHLSA--VVCALLWALSLLMNVLASFFCSEFWHPDEWQCFKV----------DMVFSF 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 208 LVLGFAIPVSTicvLYTTLLCrlhaMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQ--TPLV 285
Cdd:cd15108 158 LIMGIFTPVMA---LSSLILF----VRVRRSSRQWRRRPTRLYVVVLASVLVFLACALPLGIYWFLLYWLDLPQevKTLF 230
                       250       260       270
                ....*....|....*....|....*....|....*
gi 53828924 286 IAISYFITSLSyanSCLNPFLYAFLDASFRRNLRQ 320
Cdd:cd15108 231 SCLSRLSSSVS---SSANPVIYFLVGSRGSRRLRE 262
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
52-177 5.57e-03

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 37.93  E-value: 5.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  52 LAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLV-LPINI---ADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFL 127
Cdd:cd15006  14 LLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICASLVcVPFDIvlsASPHCCWWIYTLLFCKVIKFLHKVFCSVTVLSF 93
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 53828924 128 TVMSADRYLVVLATAEsrrvagRTYSAARAVSLAVWGIVTLVVLPFAVFA 177
Cdd:cd15006  94 AAIALDRYYSVLYPLE------RKISDAKSRDLVIYIWAHAVVASVPVFA 137
7tmA_MrgprX-like cd15106
primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A ...
47-316 7.88e-03

primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320234  Cd Length: 274  Bit Score: 37.42  E-value: 7.88e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTnLFILNLAIADELFtlvLPINIADFLLRQWPFGELM--CKLIVAIDQYNTFSSL 124
Cdd:cd15106  10 ISLVGLTGNAVVLWLLGFRMRRNAFS-VYILNLAAADFLF---LCCHIIDSLLRLINIFHIIsiPKILTNVMTFPYFAGL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 125 YFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLavWGIVTLVVLPFAVFarlddeqgrrqCVLVFPQPEAFWWRASR 204
Cdd:cd15106  86 SMLSAISTERCLSVLWPIWYRCHRPRHLSAVVCVLL--WALSLLLSILEWKF-----------CGFLFSGADSHWCQTFD 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 205 LYT---LVLGFAIPVSTICVLYTTLLCRLHAMRLdshakalerakkrvTFLVVAIL---AVCLLCWTPYHLSTVVALTTD 278
Cdd:cd15106 153 FITtawLIFLFVVLCGSSLALLVRILCGSRKMPL--------------TRLYVTILltvLVFLLCGLPFGIQWFLLLWIH 218
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 53828924 279 LPQTPLVIAISYFITSLSYANSCLNPFLYaFLDASFRR 316
Cdd:cd15106 219 IDLEVLFCHVYLVSVVLSCLNSSANPIIY-FFVGSFRQ 255
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
47-315 8.20e-03

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 37.45  E-value: 8.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924  47 ICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTL-------VLPINIADFLLRQWPF--------------- 104
Cdd:cd15350  10 IAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLyktleniLIILADMGYLNRRGPFetklddimdslfcls 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 105 --GELMCKLIVAIDQYNT-FSSLYFLTVMSADRYLVVLATAesrrvagRTYSAARAVSLAVWGIVTLVVLPFAVfarldd 181
Cdd:cd15350  90 llGSIFSILAIAADRYITiFHALRYHNIMTMRRTLVILAII-------WTFCGGSGILMILFFHFVATVICFTV------ 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 182 eqgrrqcvlvfpqpeafwwrasrLYTLVLGFaipvstICVLYTT--LLCRLHAMRLDS---HAKALERAKKRVTFLVVAI 256
Cdd:cd15350 157 -----------------------LFFLMLVL------ILCLYVHmfLLARSHARKIASlpnHHAQHQRSNMRGAITLTIL 207
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 53828924 257 LAVCLLCWTPYHLSTVVALTTDL-PQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFR 315
Cdd:cd15350 208 LGVFVCCWAPFVLHLLLMMFCPMnPYCACYRSLFQVNGTLIMSHAVIDPAIYAFRSPELR 267
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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