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Conserved domains on  [gi|5031759|ref|NP_005514|]
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homeobox protein Hox-A11 [Homo sapiens]

Protein Classification

DUF3528 and homeodomain domain-containing protein( domain architecture ID 11191843)

DUF3528 and homeodomain domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3528 pfam12045
Protein of unknown function (DUF3528); This family of proteins is functionally uncharacterized. ...
 25-153 2.66e-74

Protein of unknown function (DUF3528); This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 185 to 298 amino acids in length. This protein is found associated with pfam00046.


:

Pssm-ID: 432284  Cd Length: 127  Bit Score: 224.21  E-value: 2.66e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031759     25 PDFSSLPSFLPQTPSsRPMTYSYSSNLPQVQPVREVTFREYAIEPATKWHPRGNLAHCYSAEELVHRDCLQAPSAAgvpG 104
Cdd:pfam12045   1 PDFSSLPSFLPQTPS-CQMTYPYSSNLPQVQPVREVAFRDYALDPSSKWHHRGNYASCYSAEELVHRDCLPPSTTR---G 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 5031759    105 DVLAKSSaNVYHHPTPA---VSSNFYSTVGRNGVLPQAFDQFFETAYGTPEN 153
Cdd:pfam12045  77 EMLFKNE-SVYGHHHHGsshPSSNFYSSVGRNGVLPQGFDQFFETAYGSAEG 127
Homeodomain pfam00046
Homeodomain;
242-298 1.57e-26

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.11  E-value: 1.57e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 5031759    242 RKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKK 298
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
DUF3528 pfam12045
Protein of unknown function (DUF3528); This family of proteins is functionally uncharacterized. ...
 25-153 2.66e-74

Protein of unknown function (DUF3528); This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 185 to 298 amino acids in length. This protein is found associated with pfam00046.


Pssm-ID: 432284  Cd Length: 127  Bit Score: 224.21  E-value: 2.66e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031759     25 PDFSSLPSFLPQTPSsRPMTYSYSSNLPQVQPVREVTFREYAIEPATKWHPRGNLAHCYSAEELVHRDCLQAPSAAgvpG 104
Cdd:pfam12045   1 PDFSSLPSFLPQTPS-CQMTYPYSSNLPQVQPVREVAFRDYALDPSSKWHHRGNYASCYSAEELVHRDCLPPSTTR---G 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 5031759    105 DVLAKSSaNVYHHPTPA---VSSNFYSTVGRNGVLPQAFDQFFETAYGTPEN 153
Cdd:pfam12045  77 EMLFKNE-SVYGHHHHGsshPSSNFYSSVGRNGVLPQGFDQFFETAYGSAEG 127
Homeodomain pfam00046
Homeodomain;
242-298 1.57e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.11  E-value: 1.57e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 5031759    242 RKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKK 298
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 241-297 6.89e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 89.23  E-value: 6.89e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 5031759     241 TRKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEK 297
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 242-298 2.36e-21

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 85.37  E-value: 2.36e-21
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 5031759  242 RKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKK 298
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
229-301 8.43e-13

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 65.15  E-value: 8.43e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 5031759  229 TEDKAGGSSGQRTRKKRCpyTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKINR 301
Cdd:COG5576  41 LERKQDGSSPPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
 
Name Accession Description Interval E-value
DUF3528 pfam12045
Protein of unknown function (DUF3528); This family of proteins is functionally uncharacterized. ...
 25-153 2.66e-74

Protein of unknown function (DUF3528); This family of proteins is functionally uncharacterized. This protein is found in eukaryotes. Proteins in this family are typically between 185 to 298 amino acids in length. This protein is found associated with pfam00046.


Pssm-ID: 432284  Cd Length: 127  Bit Score: 224.21  E-value: 2.66e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031759     25 PDFSSLPSFLPQTPSsRPMTYSYSSNLPQVQPVREVTFREYAIEPATKWHPRGNLAHCYSAEELVHRDCLQAPSAAgvpG 104
Cdd:pfam12045   1 PDFSSLPSFLPQTPS-CQMTYPYSSNLPQVQPVREVAFRDYALDPSSKWHHRGNYASCYSAEELVHRDCLPPSTTR---G 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 5031759    105 DVLAKSSaNVYHHPTPA---VSSNFYSTVGRNGVLPQAFDQFFETAYGTPEN 153
Cdd:pfam12045  77 EMLFKNE-SVYGHHHHGsshPSSNFYSSVGRNGVLPQGFDQFFETAYGSAEG 127
Homeodomain pfam00046
Homeodomain;
242-298 1.57e-26

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 99.11  E-value: 1.57e-26
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 5031759    242 RKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKK 298
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 241-297 6.89e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 89.23  E-value: 6.89e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 5031759     241 TRKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEK 297
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 242-298 2.36e-21

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 85.37  E-value: 2.36e-21
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 5031759  242 RKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKK 298
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
229-301 8.43e-13

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 65.15  E-value: 8.43e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 5031759  229 TEDKAGGSSGQRTRKKRCpyTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKINR 301
Cdd:COG5576  41 LERKQDGSSPPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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