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Conserved domains on  [gi|19923356|ref|NP_006440|]
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cdc42 effector protein 3 [Homo sapiens]

Protein Classification

CRIB and BORG_CEP domain-containing protein( domain architecture ID 10210576)

CRIB and BORG_CEP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BORG_CEP pfam14957
Cdc42 effector; The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved ...
 102-253 2.87e-29

Cdc42 effector; The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved in the organization of the actin cytoskeleton. They may function as negative regulators of Rho GTPase signaling.


:

Pssm-ID: 464403  Cd Length: 121  Bit Score: 106.79  E-value: 2.87e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923356   102 VLKNAISLPTI--GGSQALMLPLLspvtfnskqesfgPAKLPRlscEPVMEEKAQEKSSLLENGTVHQGDTSWGSSGSAS 179
Cdd:pfam14957   1 LLKNAISLPQLneGGSQALTLPKL-------------PPKPPR---EPKSLSSSPEKKSLYEDGPRADSTNSAPLESPTE 64

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19923356   180 QSSQG---RDSHSSSLSEQYpdwpaedmfdhptpcelikgKTKSEESLSDLTGSLLSLQLDLGPSLLDEVLNVMDKN 253
Cdd:pfam14957  65 KLSERsfgSLTDLSSESPKY--------------------SDRSESPGLKRAESLLSLHLDLGPSILGDVLSIMDKY 121
CRIB super family cl00113
PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; ...
 30-86 1.32e-08

PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the Ras-Rac pathway. CRIB-containing effector proteins are functionally diverse and include serine/threonine kinases, tyrosine kinases, actin-binding proteins, and adapter molecules.


The actual alignment was detected with superfamily member pfam00786:

Pssm-ID: 412170  Cd Length: 59  Bit Score: 50.00  E-value: 1.32e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19923356    30 MISPPlGDFRHTIHIGKEGQHDVFGdiSFLQGNYELLPGN-----QEKAHLGQFPGHNEFFR 86
Cdd:pfam00786   1 MISAP-TNFKHTVHVGFDPDTGFFT--GLPPEWAKLLDSSgitedEQKENPKAVLDVLKFYS 59
 
Name Accession Description Interval E-value
BORG_CEP pfam14957
Cdc42 effector; The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved ...
 102-253 2.87e-29

Cdc42 effector; The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved in the organization of the actin cytoskeleton. They may function as negative regulators of Rho GTPase signaling.


Pssm-ID: 464403  Cd Length: 121  Bit Score: 106.79  E-value: 2.87e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923356   102 VLKNAISLPTI--GGSQALMLPLLspvtfnskqesfgPAKLPRlscEPVMEEKAQEKSSLLENGTVHQGDTSWGSSGSAS 179
Cdd:pfam14957   1 LLKNAISLPQLneGGSQALTLPKL-------------PPKPPR---EPKSLSSSPEKKSLYEDGPRADSTNSAPLESPTE 64

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19923356   180 QSSQG---RDSHSSSLSEQYpdwpaedmfdhptpcelikgKTKSEESLSDLTGSLLSLQLDLGPSLLDEVLNVMDKN 253
Cdd:pfam14957  65 KLSERsfgSLTDLSSESPKY--------------------SDRSESPGLKRAESLLSLHLDLGPSILGDVLSIMDKY 121
PBD pfam00786
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 30-86 1.32e-08

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 395634  Cd Length: 59  Bit Score: 50.00  E-value: 1.32e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19923356    30 MISPPlGDFRHTIHIGKEGQHDVFGdiSFLQGNYELLPGN-----QEKAHLGQFPGHNEFFR 86
Cdd:pfam00786   1 MISAP-TNFKHTVHVGFDPDTGFFT--GLPPEWAKLLDSSgitedEQKENPKAVLDVLKFYS 59
PBD smart00285
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 31-67 2.57e-05

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 197628  Cd Length: 36  Bit Score: 40.27  E-value: 2.57e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 19923356     31 ISPPLgDFRHTIHIGKEGQHDVFGDISFLQGNYELLP 67
Cdd:smart00285   1 ISTPT-NFKHIAHVGFDGQTGGFTGLPTEWKSLLKTS 36
 
Name Accession Description Interval E-value
BORG_CEP pfam14957
Cdc42 effector; The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved ...
 102-253 2.87e-29

Cdc42 effector; The Cdc42 effector (CEP) or binder of Rho GTPases (BORG) proteins are involved in the organization of the actin cytoskeleton. They may function as negative regulators of Rho GTPase signaling.


Pssm-ID: 464403  Cd Length: 121  Bit Score: 106.79  E-value: 2.87e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923356   102 VLKNAISLPTI--GGSQALMLPLLspvtfnskqesfgPAKLPRlscEPVMEEKAQEKSSLLENGTVHQGDTSWGSSGSAS 179
Cdd:pfam14957   1 LLKNAISLPQLneGGSQALTLPKL-------------PPKPPR---EPKSLSSSPEKKSLYEDGPRADSTNSAPLESPTE 64

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19923356   180 QSSQG---RDSHSSSLSEQYpdwpaedmfdhptpcelikgKTKSEESLSDLTGSLLSLQLDLGPSLLDEVLNVMDKN 253
Cdd:pfam14957  65 KLSERsfgSLTDLSSESPKY--------------------SDRSESPGLKRAESLLSLHLDLGPSILGDVLSIMDKY 121
PBD pfam00786
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 30-86 1.32e-08

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 395634  Cd Length: 59  Bit Score: 50.00  E-value: 1.32e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19923356    30 MISPPlGDFRHTIHIGKEGQHDVFGdiSFLQGNYELLPGN-----QEKAHLGQFPGHNEFFR 86
Cdd:pfam00786   1 MISAP-TNFKHTVHVGFDPDTGFFT--GLPPEWAKLLDSSgitedEQKENPKAVLDVLKFYS 59
PBD smart00285
P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also ...
 31-67 2.57e-05

P21-Rho-binding domain; Small domains that bind Cdc42p- and/or Rho-like small GTPases. Also known as the Cdc42/Rac interactive binding (CRIB).


Pssm-ID: 197628  Cd Length: 36  Bit Score: 40.27  E-value: 2.57e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 19923356     31 ISPPLgDFRHTIHIGKEGQHDVFGDISFLQGNYELLP 67
Cdd:smart00285   1 ISTPT-NFKHIAHVGFDGQTGGFTGLPTEWKSLLKTS 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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