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Conserved domains on  [gi|330443401|ref|NP_009462|]
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methionine aminopeptidase [Saccharomyces cerevisiae S288C]

Protein Classification

methionine aminopeptidase family protein( domain architecture ID 1003285)

methionine aminopeptidase family protein may cotranslationally remove the N-terminal methionine from nascent proteins; similar to fungal methionine aminopeptidase 2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00053 super family cl36503
methionine aminopeptidase 2; Provisional
 58-421 0e+00

methionine aminopeptidase 2; Provisional


The actual alignment was detected with superfamily member PTZ00053:

Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 572.43  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401  58 IELLFPDGKYPEGAWMDYhQDFNLQRTTDEEsrylKRDLERA--EHWNDVRKGAEIHRRVRRAIKDRIVPGMKLMDIADM 135
Cdd:PTZ00053 117 VSKQFKDGEYPVGEIQEY-PGENSSRTSSEE----KRELEKLseEQYQDLRRAAEVHRQVRRYAQSVIKPGVKLIDICER 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 136 IENTTRKYTGAENLLAmedpksqGIGFPTGLSLNHCAAHFTPNAGDKTVLKYEDVMKVDYGVQVNGNIIDSAFTVSFDPQ 215
Cdd:PTZ00053 192 IESKSRELIEADGLKC-------GWAFPTGCSLNHCAAHYTPNTGDKTVLTYDDVCKLDFGTHVNGRIIDCAFTVAFNPK 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 216 YDNLLAAVKDATYTGIKEAGIDVRLTDIGEAIQEVMESYEVEINGETYQVKPCRNLCGHSIAPYRIHGGKSVPIVKNGDT 295
Cdd:PTZ00053 265 YDPLLQATKDATNTGIKEAGIDVRLSDIGAAIQEVIESYEVEIKGKTYPIKSIRNLNGHSIGPYIIHGGKSVPIVKGGEN 344

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 296 TKMEEGEHFAIETFGSTGRGYVTAGGEVSHYARSAEDHQVMPTLDSAKNLLKTIDRNFGTLPFCRRYLDRLGQEKYLFAL 375
Cdd:PTZ00053 345 TRMEEGELFAIETFASTGRGYVNEDLECSHYMKDPGAEFVPLRLPKAKQLLKHINTNFGTLAFCRRWLDRLGQDRHLLAL 424

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 330443401 376 NNLVRHGLVQDYPPLNDIPGSYTAQFEHTILLHAHKKEVVSKGDDY 421
Cdd:PTZ00053 425 KQLVDAGIVNPYPPLCDVRGSYTSQMEHTILLRPTCKEVLSRGDDY 470
 
Name Accession Description Interval E-value
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 58-421 0e+00

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 572.43  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401  58 IELLFPDGKYPEGAWMDYhQDFNLQRTTDEEsrylKRDLERA--EHWNDVRKGAEIHRRVRRAIKDRIVPGMKLMDIADM 135
Cdd:PTZ00053 117 VSKQFKDGEYPVGEIQEY-PGENSSRTSSEE----KRELEKLseEQYQDLRRAAEVHRQVRRYAQSVIKPGVKLIDICER 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 136 IENTTRKYTGAENLLAmedpksqGIGFPTGLSLNHCAAHFTPNAGDKTVLKYEDVMKVDYGVQVNGNIIDSAFTVSFDPQ 215
Cdd:PTZ00053 192 IESKSRELIEADGLKC-------GWAFPTGCSLNHCAAHYTPNTGDKTVLTYDDVCKLDFGTHVNGRIIDCAFTVAFNPK 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 216 YDNLLAAVKDATYTGIKEAGIDVRLTDIGEAIQEVMESYEVEINGETYQVKPCRNLCGHSIAPYRIHGGKSVPIVKNGDT 295
Cdd:PTZ00053 265 YDPLLQATKDATNTGIKEAGIDVRLSDIGAAIQEVIESYEVEIKGKTYPIKSIRNLNGHSIGPYIIHGGKSVPIVKGGEN 344

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 296 TKMEEGEHFAIETFGSTGRGYVTAGGEVSHYARSAEDHQVMPTLDSAKNLLKTIDRNFGTLPFCRRYLDRLGQEKYLFAL 375
Cdd:PTZ00053 345 TRMEEGELFAIETFASTGRGYVNEDLECSHYMKDPGAEFVPLRLPKAKQLLKHINTNFGTLAFCRRWLDRLGQDRHLLAL 424

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 330443401 376 NNLVRHGLVQDYPPLNDIPGSYTAQFEHTILLHAHKKEVVSKGDDY 421
Cdd:PTZ00053 425 KQLVDAGIVNPYPPLCDVRGSYTSQMEHTILLRPTCKEVLSRGDDY 470
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 102-417 5.47e-171

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 480.21  E-value: 5.47e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 102 WNDVRKGAEIHRRVRRAIKDRIVPGMKLMDIADMIENTTRKYTGaenllamedpksqGIGFPTGLSLNHCAAHFTPNAGD 181
Cdd:cd01088    1 LEKYREAGEIHRQVRKYAQSLIKPGMTLLEIAEFVENRIRELGA-------------GPAFPVNLSINECAAHYTPNAGD 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 182 KTVLKYEDVMKVDYGVQVNGNIIDSAFTVSFDPQYDNLLAAVKDATYTGIKEAGIDVRLTDIGEAIQEVMESyeveinge 261
Cdd:cd01088   68 DTVLKEGDVVKLDFGAHVDGYIADSAFTVDFDPKYDDLLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIES-------- 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 262 tYQVKPCRNLCGHSIAPYRIHGGKSVPIVKNGDTTKMEEGEHFAIETFGSTGRGYVTAGGEVSHYARSAEdhqVMPTLDS 341
Cdd:cd01088  140 -YGFKPIRNLTGHSIERYRLHAGKSIPNVKGGEGTRLEEGDVYAIEPFATTGKGYVHDGPECSIYMLNRD---KPLRLPR 215

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 330443401 342 AKNLLKTIDRNFGTLPFCRRYLDRLGQEKYLFALNNLVRHGLVQDYPPLNDIPGSYTAQFEHTILLHAHKKEVVSK 417
Cdd:cd01088  216 ARKLLDVIYENFGTLPFARRWLDRLGETKLLMALKNLCKAGIVYPYPVLKEISGGYVAQFEHTIIVREDGKEVTTR 291
met_pdase_II TIGR00501
methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. ...
 95-417 3.07e-170

methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. The role of this protein in general is to produce the mature amino end of cytosolic proteins by removing the N-terminal methionine. This model describes type II, among which the eukaryotic members typically have an N-terminal extension not present in archaeal members. It can act cotranslationally. The enzyme from rat has been shown to associate with translation initiation factor 2 (IF-2) and may have a role in translational regulation. [Protein fate, Protein modification and repair]


Pssm-ID: 129592  Cd Length: 295  Bit Score: 478.51  E-value: 3.07e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401   95 DLERAEHWndVRKGaEIHRRVRRAIKDRIVPGMKLMDIADMIENTTRKYtGAEnllamedPksqgiGFPTGLSLNHCAAH 174
Cdd:TIGR00501   1 DIERAEKW--IEAG-KIHSKVRREAADRIVPGVKLLEVAEFVENRIREL-GAE-------P-----AFPCNISINECAAH 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401  175 FTPNAGDKTVLKYEDVMKVDYGVQVNGNIIDSAFTVSFDPQYDNLLAAVKDATYTGIKEAGIDVRLTDIGEAIQEVMESy 254
Cdd:TIGR00501  65 FTPKAGDKTVFKDGDVVKLDLGAHVDGYIADTAITVDLGDQYDNLVKAAKDALYTAIKEIRAGVRVGEIGKAIQEVIES- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401  255 eveingetYQVKPCRNLCGHSIAPYRIHGGKSVPIVKNGDTTKMEEGEHFAIETFGSTGRGYVTAGGEVSHYARSAEdHQ 334
Cdd:TIGR00501 144 --------YGVKPISNLTGHSMAPYRLHGGKSIPNVKERDTTKLEEGDVVAIEPFATDGVGYVTDGGEVSIYAFLAE-RP 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401  335 VMptLDSAKNLLKTIDRNFGTLPFCRRYLDRLGQEKYLFALNNLVRHGLVQDYPPLNDIPGSYTAQFEHTILLHAHKKEV 414
Cdd:TIGR00501 215 VR--LDSARNLLKTIDENYGTLPFARRWLDKLGDEKYLFALNNLIRHGLIYDYPVLNEISGGYVAQWEHTILVEEHGKEV 292


                  ...
gi 330443401  415 VSK 417
Cdd:TIGR00501 293 TTK 295
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 106-307 6.94e-28

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 109.25  E-value: 6.94e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401  106 RKGAEIHRRVRRAIKDRIVPGMKLMDIADMIENTTRKYTGAEnllamedpksqGIGFPT--GLSLNHCAAHFTPNagdKT 183
Cdd:pfam00557   4 RKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGAR-----------GPAFPPivASGPNAAIPHYIPN---DR 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401  184 VLKYEDVMKVDYGVQVNGN-IIDSAFTV---SFDPQYDNLLAAVKDATYTGIKEAGIDVRLTDIGEAIQEVMESYEVEin 259
Cdd:pfam00557  70 VLKPGDLVLIDVGAEYDGGyCSDITRTFvvgKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLG-- 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 330443401  260 getyqvKPCRNLCGHSIApYRIHGGKSVPivKNGDTTKMEEGEHFAIE 307
Cdd:pfam00557 148 ------EYFPHGLGHGIG-LEVHEGPYIS--RGGDDRVLEPGMVFTIE 186
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
106-317 1.45e-21

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 93.15  E-value: 1.45e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 106 RKGAEIHRRVRRAIKDRIVPGMKLMDIADMIENTTRKYtGAEnllamedPKSQGI-GFP--TGLSLNHCAAHFTPnagDK 182
Cdd:COG0024   13 REAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDH-GAI-------PAFLGYyGFPksICTSVNEVVVHGIP---SD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 183 TVLKYEDVMKVDYGVQVNGNIIDSAFTV---SFDPQYDNLLAAVKDATYTGIKEAGIDVRLTDIGEAIQEVMESyeveiN 259
Cdd:COG0024   82 RVLKDGDIVNIDVGAILDGYHGDSARTFvvgEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAES-----N 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 330443401 260 GetYQVkpCRNLCGHSIapyrihgGKSV---PIV----KNGDTTKMEEGEHFAIETFGSTGRGYV 317
Cdd:COG0024  157 G--YSV--VREFVGHGI-------GREMheePQVpnygRPGRGPRLKPGMVLAIEPMINAGTPEV 210
 
Name Accession Description Interval E-value
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 58-421 0e+00

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 572.43  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401  58 IELLFPDGKYPEGAWMDYhQDFNLQRTTDEEsrylKRDLERA--EHWNDVRKGAEIHRRVRRAIKDRIVPGMKLMDIADM 135
Cdd:PTZ00053 117 VSKQFKDGEYPVGEIQEY-PGENSSRTSSEE----KRELEKLseEQYQDLRRAAEVHRQVRRYAQSVIKPGVKLIDICER 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 136 IENTTRKYTGAENLLAmedpksqGIGFPTGLSLNHCAAHFTPNAGDKTVLKYEDVMKVDYGVQVNGNIIDSAFTVSFDPQ 215
Cdd:PTZ00053 192 IESKSRELIEADGLKC-------GWAFPTGCSLNHCAAHYTPNTGDKTVLTYDDVCKLDFGTHVNGRIIDCAFTVAFNPK 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 216 YDNLLAAVKDATYTGIKEAGIDVRLTDIGEAIQEVMESYEVEINGETYQVKPCRNLCGHSIAPYRIHGGKSVPIVKNGDT 295
Cdd:PTZ00053 265 YDPLLQATKDATNTGIKEAGIDVRLSDIGAAIQEVIESYEVEIKGKTYPIKSIRNLNGHSIGPYIIHGGKSVPIVKGGEN 344

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 296 TKMEEGEHFAIETFGSTGRGYVTAGGEVSHYARSAEDHQVMPTLDSAKNLLKTIDRNFGTLPFCRRYLDRLGQEKYLFAL 375
Cdd:PTZ00053 345 TRMEEGELFAIETFASTGRGYVNEDLECSHYMKDPGAEFVPLRLPKAKQLLKHINTNFGTLAFCRRWLDRLGQDRHLLAL 424

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 330443401 376 NNLVRHGLVQDYPPLNDIPGSYTAQFEHTILLHAHKKEVVSKGDDY 421
Cdd:PTZ00053 425 KQLVDAGIVNPYPPLCDVRGSYTSQMEHTILLRPTCKEVLSRGDDY 470
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 102-417 5.47e-171

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 480.21  E-value: 5.47e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 102 WNDVRKGAEIHRRVRRAIKDRIVPGMKLMDIADMIENTTRKYTGaenllamedpksqGIGFPTGLSLNHCAAHFTPNAGD 181
Cdd:cd01088    1 LEKYREAGEIHRQVRKYAQSLIKPGMTLLEIAEFVENRIRELGA-------------GPAFPVNLSINECAAHYTPNAGD 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 182 KTVLKYEDVMKVDYGVQVNGNIIDSAFTVSFDPQYDNLLAAVKDATYTGIKEAGIDVRLTDIGEAIQEVMESyeveinge 261
Cdd:cd01088   68 DTVLKEGDVVKLDFGAHVDGYIADSAFTVDFDPKYDDLLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIES-------- 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 262 tYQVKPCRNLCGHSIAPYRIHGGKSVPIVKNGDTTKMEEGEHFAIETFGSTGRGYVTAGGEVSHYARSAEdhqVMPTLDS 341
Cdd:cd01088  140 -YGFKPIRNLTGHSIERYRLHAGKSIPNVKGGEGTRLEEGDVYAIEPFATTGKGYVHDGPECSIYMLNRD---KPLRLPR 215

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 330443401 342 AKNLLKTIDRNFGTLPFCRRYLDRLGQEKYLFALNNLVRHGLVQDYPPLNDIPGSYTAQFEHTILLHAHKKEVVSK 417
Cdd:cd01088  216 ARKLLDVIYENFGTLPFARRWLDRLGETKLLMALKNLCKAGIVYPYPVLKEISGGYVAQFEHTIIVREDGKEVTTR 291
met_pdase_II TIGR00501
methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. ...
 95-417 3.07e-170

methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. The role of this protein in general is to produce the mature amino end of cytosolic proteins by removing the N-terminal methionine. This model describes type II, among which the eukaryotic members typically have an N-terminal extension not present in archaeal members. It can act cotranslationally. The enzyme from rat has been shown to associate with translation initiation factor 2 (IF-2) and may have a role in translational regulation. [Protein fate, Protein modification and repair]


Pssm-ID: 129592  Cd Length: 295  Bit Score: 478.51  E-value: 3.07e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401   95 DLERAEHWndVRKGaEIHRRVRRAIKDRIVPGMKLMDIADMIENTTRKYtGAEnllamedPksqgiGFPTGLSLNHCAAH 174
Cdd:TIGR00501   1 DIERAEKW--IEAG-KIHSKVRREAADRIVPGVKLLEVAEFVENRIREL-GAE-------P-----AFPCNISINECAAH 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401  175 FTPNAGDKTVLKYEDVMKVDYGVQVNGNIIDSAFTVSFDPQYDNLLAAVKDATYTGIKEAGIDVRLTDIGEAIQEVMESy 254
Cdd:TIGR00501  65 FTPKAGDKTVFKDGDVVKLDLGAHVDGYIADTAITVDLGDQYDNLVKAAKDALYTAIKEIRAGVRVGEIGKAIQEVIES- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401  255 eveingetYQVKPCRNLCGHSIAPYRIHGGKSVPIVKNGDTTKMEEGEHFAIETFGSTGRGYVTAGGEVSHYARSAEdHQ 334
Cdd:TIGR00501 144 --------YGVKPISNLTGHSMAPYRLHGGKSIPNVKERDTTKLEEGDVVAIEPFATDGVGYVTDGGEVSIYAFLAE-RP 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401  335 VMptLDSAKNLLKTIDRNFGTLPFCRRYLDRLGQEKYLFALNNLVRHGLVQDYPPLNDIPGSYTAQFEHTILLHAHKKEV 414
Cdd:TIGR00501 215 VR--LDSARNLLKTIDENYGTLPFARRWLDKLGDEKYLFALNNLIRHGLIYDYPVLNEISGGYVAQWEHTILVEEHGKEV 292


                  ...
gi 330443401  415 VSK 417
Cdd:TIGR00501 293 TTK 295
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 84-407 3.86e-35

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 133.86  E-value: 3.86e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401   84 TTDEESRYLKRDLERAEHWNDVRKGAEIHRRVRRAIKDRIVPGMKLMDIA----DMIENTTRK-YTGAENLlamedpkSQ 158
Cdd:TIGR00495   2 SGKDEQQEQAYSLSNPEVVTKYKMAGEIANNVLKSVVEACSPGAKVVDICekgdAFIMEETAKiFKKEKEM-------EK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401  159 GIGFPTGLSLNHCAAHFTPNAGDKT-VLKYEDVMKVDYGVQVNGNIIDSAFTVSFDPQYDNLL----AAVKDATYTGIKE 233
Cdd:TIGR00495  75 GIAFPTCISVNNCVGHFSPLKSDQDyILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEEPVtgrkADVIAAAHLAAEA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401  234 AGIDVRL----TDIGEAIQEVMESYEVeingetyqvKPCRNLCGHSIAPYRIHGGKSVPIV------KNGDTTKMEEGEH 303
Cdd:TIGR00495 155 ALRLVKPgntnTQVTEAINKVAHSYGC---------TPVEGMLSHQLKQHVIDGEKVIISNpsdsqkKDHDTAEFEENEV 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401  304 FAIETFGSTGRGYVTAGGEVSHYARSAEDHQVMPTLDSAKNLLKTIDRNFGTLPFCRRYLDrlGQEKYLFALNNLVRHGL 383
Cdd:TIGR00495 226 YAVDILVSTGEGKAKDADQRTTIYKRDPSKTYGLKMKASRAFFSEIERRFDAMPFTLRNFE--DEKRARMGLVECVKHEL 303

                         330       340
                  ....*....|....*....|....
gi 330443401  384 VQDYPPLNDIPGSYTAQFEHTILL 407
Cdd:TIGR00495 304 LQPYPVLYEKEGEFVAQFKFTVLL 327
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 106-307 6.94e-28

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 109.25  E-value: 6.94e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401  106 RKGAEIHRRVRRAIKDRIVPGMKLMDIADMIENTTRKYTGAEnllamedpksqGIGFPT--GLSLNHCAAHFTPNagdKT 183
Cdd:pfam00557   4 RKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGAR-----------GPAFPPivASGPNAAIPHYIPN---DR 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401  184 VLKYEDVMKVDYGVQVNGN-IIDSAFTV---SFDPQYDNLLAAVKDATYTGIKEAGIDVRLTDIGEAIQEVMESYEVEin 259
Cdd:pfam00557  70 VLKPGDLVLIDVGAEYDGGyCSDITRTFvvgKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLG-- 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 330443401  260 getyqvKPCRNLCGHSIApYRIHGGKSVPivKNGDTTKMEEGEHFAIE 307
Cdd:pfam00557 148 ------EYFPHGLGHGIG-LEVHEGPYIS--RGGDDRVLEPGMVFTIE 186
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 106-318 7.89e-26

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 104.50  E-value: 7.89e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 106 RKGAEIHRRVRRAIKDRIVPGMKLMDIADMIENTTRKYtgaenlLAMEDPKSQGiGFP--TGLSLNHCAAHFTPnagDKT 183
Cdd:cd01086    5 REAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEH------GAYPAPLGYY-GFPksICTSVNEVVCHGIP---DDR 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 184 VLKYEDVMKVDYGVQVNGNIIDSAFTV---SFDPQYDNLLAAVKDATYTGIKEAGIDVRLTDIGEAIQEVMESYeveing 260
Cdd:cd01086   75 VLKDGDIVNIDVGVELDGYHGDSARTFivgEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKN------ 148

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 330443401 261 eTYQVkpCRNLCGHSIAPYrIHGGKSVPIV-KNGDTTKMEEGEHFAIETFGSTGRGYVT 318
Cdd:cd01086  149 -GYSV--VREFGGHGIGRK-FHEEPQIPNYgRPGTGPKLKPGMVFTIEPMINLGTYEVV 203
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
106-317 1.45e-21

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 93.15  E-value: 1.45e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 106 RKGAEIHRRVRRAIKDRIVPGMKLMDIADMIENTTRKYtGAEnllamedPKSQGI-GFP--TGLSLNHCAAHFTPnagDK 182
Cdd:COG0024   13 REAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDH-GAI-------PAFLGYyGFPksICTSVNEVVVHGIP---SD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 183 TVLKYEDVMKVDYGVQVNGNIIDSAFTV---SFDPQYDNLLAAVKDATYTGIKEAGIDVRLTDIGEAIQEVMESyeveiN 259
Cdd:COG0024   82 RVLKDGDIVNIDVGAILDGYHGDSARTFvvgEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAES-----N 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 330443401 260 GetYQVkpCRNLCGHSIapyrihgGKSV---PIV----KNGDTTKMEEGEHFAIETFGSTGRGYV 317
Cdd:COG0024  157 G--YSV--VREFVGHGI-------GREMheePQVpnygRPGRGPRLKPGMVLAIEPMINAGTPEV 210
PRK05716 PRK05716
methionine aminopeptidase; Validated
 106-318 3.62e-20

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 89.04  E-value: 3.62e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 106 RKGAEIHRRVRRAIKDRIVPGMKLMDIADMIENTTRKYtGAEnllamedPKSQGI-GFP--TGLSLNHCAAHFTPnagDK 182
Cdd:PRK05716  15 RVAGRLAAEVLDEIEPHVKPGVTTKELDRIAEEYIRDQ-GAI-------PAPLGYhGFPksICTSVNEVVCHGIP---SD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 183 TVLKYEDVMKVDYGVQVNGNIIDSAFTVSF---DPQYDNLLAAVKDATYTGIKEAGIDVRLTDIGEAIQEVMESyevein 259
Cdd:PRK05716  84 KVLKEGDIVNIDVTVIKDGYHGDTSRTFGVgeiSPEDKRLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEA------ 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 260 gETYQVkpCRNLCGHSIAPyRIHGGKSVP-IVKNGDTTKMEEGEHFAIETFGSTGRGYVT 318
Cdd:PRK05716 158 -EGFSV--VREYCGHGIGR-KFHEEPQIPhYGAPGDGPVLKEGMVFTIEPMINAGKREVK 213
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 105-309 1.05e-18

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 84.04  E-value: 1.05e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 105 VRKGAEIHRRVRRAIKDRIVPGMKLMDIADMIENTTRKYTGAEnllamedpksqgiGFPTGLSLNH--CAAHFTPNAgdk 182
Cdd:cd01066    4 LRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGGYP-------------AGPTIVGSGArtALPHYRPDD--- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 183 TVLKYEDVMKVDYGVQVNGNIIDSAFTVSFDPQYD---NLLAAVKDATYTGIKEAGIDVRLTDIGEAIQEVMESYEVEin 259
Cdd:cd01066   68 RRLQEGDLVLVDLGGVYDGYHADLTRTFVIGEPSDeqrELYEAVREAQEAALAALRPGVTAEEVDAAAREVLEEHGLG-- 145

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 330443401 260 getyqvKPCRNLCGHSIaPYRIHGGksvPIVKNGDTTKMEEGEHFAIETF 309
Cdd:cd01066  146 ------PNFGHRTGHGI-GLEIHEP---PVLKAGDDTVLEPGMVFAVEPG 185
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 106-342 1.65e-13

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 69.87  E-value: 1.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 106 RKGAEIHRRVRRAIKDRIVPGMKLMDIaDMIentTRKYtgaenllaMED----PKSQGI-GFP--TGLSLNHCAAHFTPn 178
Cdd:PRK12896  20 RKIGRIVATALKEMGKAVEPGMTTKEL-DRI---AEKR--------LEEhgaiPSPEGYyGFPgsTCISVNEEVAHGIP- 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 179 agDKTVLKYEDVMKVDYGVQVNGNIIDSAFTV---SFDPQYDNLLAAVKDATYTGIKEAGIDVRLTDIGEAIQEvmesyE 255
Cdd:PRK12896  87 --GPRVIKDGDLVNIDVSAYLDGYHGDTGITFavgPVSEEAEKLCRVAEEALWAGIKQVKAGRPLNDIGRAIED-----F 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 256 VEINGetYQVkpCRNLCGHSIAPyRIHGGKSVPIV--KNGDTTKMEEGEHFAIETFGSTGrgyvtaggevSHYARSAEDH 333
Cdd:PRK12896 160 AKKNG--YSV--VRDLTGHGVGR-SLHEEPSVILTytDPLPNRLLRPGMTLAVEPFLNLG----------AKDAETLDDG 224


                 ....*....
gi 330443401 334 QVMPTLDSA 342
Cdd:PRK12896 225 WTVVTPDKS 233
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 106-416 1.97e-13

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 69.28  E-value: 1.97e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 106 RKGAEIHRRVRRAIKDRIVPGMKLMDIAD----MIENTTRK-YTGAENLlamedpkSQGIGFPTGLSLNHCAAHFTPNAG 180
Cdd:cd01089    5 KTAGQIANKVLKQVISLCVPGAKVVDLCEkgdkLILEELGKvYKKEKKL-------EKGIAFPTCISVNNCVCHFSPLKS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 181 DKTV-LKYEDVMKVDYGVQVNGNIIDSAFTVsfdpqydnLLAAVKDATYTGikeagidvRLTDIGEAIQEVMEsyevein 259
Cdd:cd01089   78 DATYtLKDGDVVKIDLGCHIDGYIAVVAHTI--------VVGAEAETPVTG--------KKADVIAAAHYALE------- 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 260 getyqvkpcrnLCGHSIAPyrihGGKSVPIVKNGDTTkmeegehfaIETFGSTGRGYVTaggevSHyarsaEDHQVMPTL 339
Cdd:cd01089  135 -----------AALRLLRP----GNQNSDITEAIQKV---------IVDYGCTPVEGVL-----SH-----QLKRVVSSG 180

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 330443401 340 DsaknllktidrnfgtlpfcrryldrlGQEKylfaLNNLVRHGLVQDYPPLNDIPGSYTAQFEHTILLHAHKKEVVS 416
Cdd:cd01089  181 E--------------------------GKAK----LVECVKHGLLFPYPVLYEKEGEVVAQFKLTVLLTPNGVTVLT 227
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
106-307 3.08e-08

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 54.83  E-value: 3.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 106 RKGAEIHRRVRRAIKDRIVPGMKLMDIADMIENTTRKYtGAEnllamedpksqGIGFPTGLSL--NHCAAHFTPNAgdkT 183
Cdd:COG0006   83 RKAARIADAAHEAALAALRPGVTEREVAAELEAAMRRR-GAE-----------GPSFDTIVASgeNAAIPHYTPTD---R 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 184 VLKYEDVMKVDYGVQVNGNIIDSAFTVSF---DPQYDNLLAAVKDATYTGIKEAGIDVRLTDIGEAIQEVMESYEVeinG 260
Cdd:COG0006  148 PLKPGDLVLIDAGAEYDGYTSDITRTVAVgepSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGY---G 224

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 330443401 261 ETYqvkPCRnlCGHSIApYRIHGGksvPIVKNGDTTKMEEGEHFAIE 307
Cdd:COG0006  225 EYF---PHG--TGHGVG-LDVHEG---PQISPGNDRPLEPGMVFTIE 262
PRK07281 PRK07281
methionyl aminopeptidase;
109-313 5.33e-08

methionyl aminopeptidase;


Pssm-ID: 180918  Cd Length: 286  Bit Score: 54.08  E-value: 5.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 109 AEIHRRVRRAIKdrivPGMKLMDIadmiENTTRKYTGAENLLAME---DPKSQGIGFPTGLSLNHCAAHFTPNagdKTVL 185
Cdd:PRK07281  21 ASIHIGLRDLIK----PGVDMWEV----EEYVRRRCKEENVLPLQigvDGAMMDYPYATCCGLNDEVAHAFPR---HYIL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 186 KYEDVMKVD---------------------------YGVQVNGNIIDS--AFTV-SFDPQYDNLLAAVKDATYTGIKEAG 235
Cdd:PRK07281  90 KEGDLLKVDmvlsepldksivdvsklnfdnveqmkkYTESYRGGLADScwAYAVgTPSDEVKNLMDVTKEAMYRGIEQAV 169

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 330443401 236 IDVRLTDIGEAIQEVMESYeveingeTYQVkpCRNLCGHSIAPyRIHGGKSVPIV-KNGDTTKMEEGEHFAIETFGSTG 313
Cdd:PRK07281 170 VGNRIGDIGAAIQEYAESR-------GYGV--VRDLVGHGVGP-TMHEEPMVPNYgTAGRGLRLREGMVLTIEPMINTG 238
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 106-307 2.57e-06

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 47.89  E-value: 2.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 106 RKGAEIHRRVRRAIKDRIVPGMKLMDIADMIENTTRKYtGAEnllamedpksqGIGFPTGLSLNHCAA--HFTPnagDKT 183
Cdd:cd01092    5 RKAARIADKAFEELLEFIKPGMTEREVAAELEYFMRKL-GAE-----------GPSFDTIVASGPNSAlpHGVP---SDR 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443401 184 VLKYEDVMKVDYGVQVNGNIIDSAFTVSF---DPQYDNLLAAVKDATYTGIKEAGIDVRLTDIGEAIQEVMESYEVeinG 260
Cdd:cd01092   70 KIEEGDLVLIDFGAIYDGYCSDITRTVAVgepSDELKEIYEIVLEAQQAAIKAVKPGVTAKEVDKAARDVIEEAGY---G 146

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 330443401 261 ETYqvkpcrnlcGHSIApyriHG-GKSV---PIVKNGDTTKMEEGEHFAIE 307
Cdd:cd01092  147 EYF---------IHRTG----HGvGLEVheaPYISPGSDDVLEEGMVFTIE 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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