NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|6319392|ref|NP_009474|]
View 

Nup170p [Saccharomyces cerevisiae S288C]

Protein Classification

nuclear pore complex Nup155/Nup170 family protein( domain architecture ID 11474919)

nuclear pore complex Nup155/Nup170 family protein is required for both nuclear envelope (NE) membrane fusion and nuclear pore complexes (NPCs) assembly

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
NUP170 COG5308
Nuclear pore complex subunit [Intracellular trafficking and secretion];
83-1496 0e+00

Nuclear pore complex subunit [Intracellular trafficking and secretion];


:

Pssm-ID: 227624 [Multi-domain]  Cd Length: 1263  Bit Score: 1754.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392    83 MSNMNEHIRVSGMGTSKPLDLAGKYIDHLQHKDSNTPVLDERSYYNSGVDYNFSREKNglgaFTPFEKQDVFNIPDEILH 162
Cdd:COG5308    1 MRQEGPHVGVSGMGYYELLLLALHWIGMLLKRDTKTPSLDEAKYYEEGLDYIFSIETG----FTPFYAQQVMNIPDRILS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   163 EFSTSQTKTDMGIFPELNRCWITIDNKLILWNINNDNEYQVVDDMKHTIQKVALVRPKPNTFVPAVKHLLLISTTMELFM 242
Cdd:COG5308   77 QISRTEYKTDMGIFPELNRCWITNDNKLILWNYNNSNEYQEIDDFSHTILKVKLVRPKANTFVSRISHLLFVATEKEVMI 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   243 FAISLDKATNELSVFNTHLSVPVQGIDVIDIVSHErSGRIFFAGQAsGLNIWELHYSGSDDWFNSKCSKVCLTKSALLSL 322
Cdd:COG5308  157 LGVSKDTKTGELSLFNTGLVVSVQGINVRCIVSEE-DGRIFFGGEN-DPNVYELVYKSSDSWFNSKCSKICLTKSILSSL 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   323 LPTNMLSQIPGvdfiqalfednsngnggfsqETITQLTIDQQRGIIYSLSSKSTIRAYVITEKSLEGPMSIEPAYISRII 402
Cdd:COG5308  235 LPSFFSFGIPG--------------------ETIKQLAVDQSRGLLYVLRKKSAVRAYSITKNGLVGPVFISFASIDRNA 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   403 GTTTArAAPILGPKYLKIVKISSVAPEENNNLFLVALTVGGVRLYFNGSMGRFNIEALRLESIKFPPSSVTPEViqqell 482
Cdd:COG5308  295 AILNA-TSPLLEPRMYKIVKIVSIPAYENNQLFLVAITSTGCRLYFDGSRGRVSIVALKLDSVKFPPPSTLMQL------ 367
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   483 hqqqEQAKRSFPFFSNLMSSEPVLLKFQKKSSVLLETTKASTIISPGIFFSAVIKSSQqTHQQEKkenssvtGTTATAGS 562
Cdd:COG5308  368 ----EQNKGSRDFYENLFLDRLVMLKRQPNSSDMTETTEMSTIISPGIYFSAVNKRYD-SSNTNK-------GSTVTAIS 435
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   563 KTVKQqpvtlqHKLFVSVPDYGILKTHgKYVENATFLETAGPVQQIIPLSGLFNATTKPQGfanEFATQYTSETLRVAVL 642
Cdd:COG5308  436 LNVDQ------HKLWVSIPDYGILKSS-KYVENVVFLDDIELIQNIDPRTELFNQTNTPQA---TFALLYGNEKLFVAVL 505
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   643 TSTSIEIYKYRTPDEIFEDLIDNPLPFVLNYGAAEACSTALFVTCKSNKSEKLRSNALTFLTMGIPGVVDIKPVYNRYSV 722
Cdd:COG5308  506 TSVEKEIYSYRTPDEIFSGLIGNPLPFYKSYGEAEACSTALLYYCKLNKSEDVGSLALLFLKLGIPDVVDIKPKYYRYSG 585
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   723 StvssllsKPTLStattnlqQSItgFSKPSpankedfDLDDVILSPRFYGIALLITRLLRDIWGRHVFMTftdnrvtsha 802
Cdd:COG5308  586 S-------VPILS-------QSR--FNKPS-------SLDFVRLSPRFYGLALLITRLERNIWLERVFSK---------- 632
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   803 fisssdpitpsinnLKSDEISQNRNIIskvsisKDCIEYYLSSINILNEFFITYGDSISQISAPyvLANNsngrvidktE 882
Cdd:COG5308  633 --------------MQNKMINIRGASI------KIKIEYYLSGIDFLDEFLENNKSSIEGLNSP--LISN---------D 681
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   883 EVANQAESIAINAMIKMVQSIKEGLSFLNVLYEEsevegfdnQYLGFKDIISFVSLDVQKDLVKLDFKDLFAPNdKTKSL 962
Cdd:COG5308  682 EIAVQAESIANNALLLEYQSIKEGLSLLNVLYED--------GVSDFHEIVSSTSIDIQKSCSNLTFSELFTPN-KTKKL 752
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   963 IREILLSIINRNITKGASIEYTATALQERCGSFCSASDILGFRAIEHLRRAKEIGlRNYDSLNYHLKNATALLEQIVDDL 1042
Cdd:COG5308  753 IKEILKSLVNRNIQSGGSIEYLIKTLSERCGSFCSAEDVLYFRALEHLNKAKSRE-VDLESLNNHLKNAVQLNESLVAKY 831
                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392  1043 SIEKLKEAVSMMLSVNYYPKSIEFLLNIANSMDKGKLACQYVANGFLENDDRKQYYDKRILVYDLVFDTLIKVDELAEkk 1122
Cdd:COG5308  832 NEEGLRYAVTTMISLNYYPKAVNFLLEYAVEIDKGNQACAYVLNGLAENDPRKDFYDKRIKVYSLIFEILISVDKENS-- 909
                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392  1123 qssktqnqisisnDDEVKLRQKSYEAALKYNDRLFHYHMYDWLVSQNREEKLLDIETPFILPYLMEKAGSSLKISNILWV 1202
Cdd:COG5308  910 -------------LRNSELKCCVYPSAMGSNDRLFHYCFYDWLVFKGRTDRLIKIDSPFILPYLKEKAMSSLKISNLLWK 976
                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392  1203 YYSRRSKFFESAEILYRLATSNFDITLFERIEFLSRANGFCNSVSPLSQKQRIVQLASRIQDACEVAGIQGDILSLVYTD 1282
Cdd:COG5308  977 YYVKREDFVEAAQVLYELATSNFDVSLEERIELLRRANGFCSSHVPNSQKHVNVQLFNEVKERLEVASIQDDILRLVRVD 1056
                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392  1283 ARIDSAIKDELIKTLDGKILSTSELFNDFAVPLSYHEIALFIFKIADFRDHEVIMAKWDELFQSLRMEFNNTGKKEDSMN 1362
Cdd:COG5308 1057 PRIDNNKREELSKQLDGEILSLSELFNDYADPLKYPEIALKIFKISDYRDKAVIRELWEELMSSHENAIISPVGSSDFES 1136
                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392  1363 FINLLSNVLIKIGKnvqdSEFIFPIFELFPIVCNFFYEtlpKEHIVSGSIVSIFITAGVSFNKMYYILKELIETSDSDNS 1442
Cdd:COG5308 1137 FVSFLSNLLIKISK----SENVFPIMDLNDIVGDIFCD---KEMAAGGSVGSAFLSAGVSHLKVYYILEELIEQSKDRLF 1209
                       1370      1380      1390      1400      1410
                 ....*....|....*....|....*....|....*....|....*....|....
gi 6319392  1443 VFNKEMTWLIHEWYKSDRKFRDIISYNDIIHLKEYKIDNDPIEKYVKNSGNNLG 1496
Cdd:COG5308 1210 FLIKEMTWLIKEWYHSDMSFRARILLEDIKKLKNYNEFYDPVEKYCKRKYGILD 1263
 
Name Accession Description Interval E-value
NUP170 COG5308
Nuclear pore complex subunit [Intracellular trafficking and secretion];
83-1496 0e+00

Nuclear pore complex subunit [Intracellular trafficking and secretion];


Pssm-ID: 227624 [Multi-domain]  Cd Length: 1263  Bit Score: 1754.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392    83 MSNMNEHIRVSGMGTSKPLDLAGKYIDHLQHKDSNTPVLDERSYYNSGVDYNFSREKNglgaFTPFEKQDVFNIPDEILH 162
Cdd:COG5308    1 MRQEGPHVGVSGMGYYELLLLALHWIGMLLKRDTKTPSLDEAKYYEEGLDYIFSIETG----FTPFYAQQVMNIPDRILS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   163 EFSTSQTKTDMGIFPELNRCWITIDNKLILWNINNDNEYQVVDDMKHTIQKVALVRPKPNTFVPAVKHLLLISTTMELFM 242
Cdd:COG5308   77 QISRTEYKTDMGIFPELNRCWITNDNKLILWNYNNSNEYQEIDDFSHTILKVKLVRPKANTFVSRISHLLFVATEKEVMI 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   243 FAISLDKATNELSVFNTHLSVPVQGIDVIDIVSHErSGRIFFAGQAsGLNIWELHYSGSDDWFNSKCSKVCLTKSALLSL 322
Cdd:COG5308  157 LGVSKDTKTGELSLFNTGLVVSVQGINVRCIVSEE-DGRIFFGGEN-DPNVYELVYKSSDSWFNSKCSKICLTKSILSSL 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   323 LPTNMLSQIPGvdfiqalfednsngnggfsqETITQLTIDQQRGIIYSLSSKSTIRAYVITEKSLEGPMSIEPAYISRII 402
Cdd:COG5308  235 LPSFFSFGIPG--------------------ETIKQLAVDQSRGLLYVLRKKSAVRAYSITKNGLVGPVFISFASIDRNA 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   403 GTTTArAAPILGPKYLKIVKISSVAPEENNNLFLVALTVGGVRLYFNGSMGRFNIEALRLESIKFPPSSVTPEViqqell 482
Cdd:COG5308  295 AILNA-TSPLLEPRMYKIVKIVSIPAYENNQLFLVAITSTGCRLYFDGSRGRVSIVALKLDSVKFPPPSTLMQL------ 367
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   483 hqqqEQAKRSFPFFSNLMSSEPVLLKFQKKSSVLLETTKASTIISPGIFFSAVIKSSQqTHQQEKkenssvtGTTATAGS 562
Cdd:COG5308  368 ----EQNKGSRDFYENLFLDRLVMLKRQPNSSDMTETTEMSTIISPGIYFSAVNKRYD-SSNTNK-------GSTVTAIS 435
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   563 KTVKQqpvtlqHKLFVSVPDYGILKTHgKYVENATFLETAGPVQQIIPLSGLFNATTKPQGfanEFATQYTSETLRVAVL 642
Cdd:COG5308  436 LNVDQ------HKLWVSIPDYGILKSS-KYVENVVFLDDIELIQNIDPRTELFNQTNTPQA---TFALLYGNEKLFVAVL 505
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   643 TSTSIEIYKYRTPDEIFEDLIDNPLPFVLNYGAAEACSTALFVTCKSNKSEKLRSNALTFLTMGIPGVVDIKPVYNRYSV 722
Cdd:COG5308  506 TSVEKEIYSYRTPDEIFSGLIGNPLPFYKSYGEAEACSTALLYYCKLNKSEDVGSLALLFLKLGIPDVVDIKPKYYRYSG 585
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   723 StvssllsKPTLStattnlqQSItgFSKPSpankedfDLDDVILSPRFYGIALLITRLLRDIWGRHVFMTftdnrvtsha 802
Cdd:COG5308  586 S-------VPILS-------QSR--FNKPS-------SLDFVRLSPRFYGLALLITRLERNIWLERVFSK---------- 632
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   803 fisssdpitpsinnLKSDEISQNRNIIskvsisKDCIEYYLSSINILNEFFITYGDSISQISAPyvLANNsngrvidktE 882
Cdd:COG5308  633 --------------MQNKMINIRGASI------KIKIEYYLSGIDFLDEFLENNKSSIEGLNSP--LISN---------D 681
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   883 EVANQAESIAINAMIKMVQSIKEGLSFLNVLYEEsevegfdnQYLGFKDIISFVSLDVQKDLVKLDFKDLFAPNdKTKSL 962
Cdd:COG5308  682 EIAVQAESIANNALLLEYQSIKEGLSLLNVLYED--------GVSDFHEIVSSTSIDIQKSCSNLTFSELFTPN-KTKKL 752
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   963 IREILLSIINRNITKGASIEYTATALQERCGSFCSASDILGFRAIEHLRRAKEIGlRNYDSLNYHLKNATALLEQIVDDL 1042
Cdd:COG5308  753 IKEILKSLVNRNIQSGGSIEYLIKTLSERCGSFCSAEDVLYFRALEHLNKAKSRE-VDLESLNNHLKNAVQLNESLVAKY 831
                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392  1043 SIEKLKEAVSMMLSVNYYPKSIEFLLNIANSMDKGKLACQYVANGFLENDDRKQYYDKRILVYDLVFDTLIKVDELAEkk 1122
Cdd:COG5308  832 NEEGLRYAVTTMISLNYYPKAVNFLLEYAVEIDKGNQACAYVLNGLAENDPRKDFYDKRIKVYSLIFEILISVDKENS-- 909
                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392  1123 qssktqnqisisnDDEVKLRQKSYEAALKYNDRLFHYHMYDWLVSQNREEKLLDIETPFILPYLMEKAGSSLKISNILWV 1202
Cdd:COG5308  910 -------------LRNSELKCCVYPSAMGSNDRLFHYCFYDWLVFKGRTDRLIKIDSPFILPYLKEKAMSSLKISNLLWK 976
                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392  1203 YYSRRSKFFESAEILYRLATSNFDITLFERIEFLSRANGFCNSVSPLSQKQRIVQLASRIQDACEVAGIQGDILSLVYTD 1282
Cdd:COG5308  977 YYVKREDFVEAAQVLYELATSNFDVSLEERIELLRRANGFCSSHVPNSQKHVNVQLFNEVKERLEVASIQDDILRLVRVD 1056
                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392  1283 ARIDSAIKDELIKTLDGKILSTSELFNDFAVPLSYHEIALFIFKIADFRDHEVIMAKWDELFQSLRMEFNNTGKKEDSMN 1362
Cdd:COG5308 1057 PRIDNNKREELSKQLDGEILSLSELFNDYADPLKYPEIALKIFKISDYRDKAVIRELWEELMSSHENAIISPVGSSDFES 1136
                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392  1363 FINLLSNVLIKIGKnvqdSEFIFPIFELFPIVCNFFYEtlpKEHIVSGSIVSIFITAGVSFNKMYYILKELIETSDSDNS 1442
Cdd:COG5308 1137 FVSFLSNLLIKISK----SENVFPIMDLNDIVGDIFCD---KEMAAGGSVGSAFLSAGVSHLKVYYILEELIEQSKDRLF 1209
                       1370      1380      1390      1400      1410
                 ....*....|....*....|....*....|....*....|....*....|....
gi 6319392  1443 VFNKEMTWLIHEWYKSDRKFRDIISYNDIIHLKEYKIDNDPIEKYVKNSGNNLG 1496
Cdd:COG5308 1210 FLIKEMTWLIKEWYHSDMSFRARILLEDIKKLKNYNEFYDPVEKYCKRKYGILD 1263
Nucleoporin_C pfam03177
Non-repetitive/WGA-negative nucleoporin C-terminal; This is the C-termainl half of a family of ...
832-1392 1.67e-103

Non-repetitive/WGA-negative nucleoporin C-terminal; This is the C-termainl half of a family of nucleoporin proteins. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells, and mediate bidirectional nucleocytoplasmic transport, especially of mRNA and proteins. Two nucleoporin classes are known: one is characterized by the FG repeat pfam03093; the other is represented by this family, and lacks any repeats. RNA undergoing nuclear export first encounters the basket of the nuclear pore and many nucleoporins are accessible on the basket side of the pore.


Pssm-ID: 427181  Cd Length: 559  Bit Score: 342.37  E-value: 1.67e-103
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392     832 VSISKDCIEYYLSSINILNEFFITYGDSISQisapyvlannsngrviDKTEEVANQAESIA------------------- 892
Cdd:pfam03177    1 LASLEQNLELRLSALDDLAEFLKSNGVSIDR----------------DTRWELLWQAEKIAaatalwkkheaflaerpek 64
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392     893 ---INAMIKMVQSIKEGLSFLNVLYEESEV--------EGFDNQYLGFKDI--------------------ISFVSLDVQ 941
Cdd:pfam03177   65 rtlLNSIIKLINSMKEALSFLNVLYEANEIslaaleeaFGFRDENAAFYGIgdelledgieglpepwtstsYIYSNLKRQ 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392     942 KDLVKLDFKDLFAPNdktkslireillsiinrniTKGASIEYTATALQERCGSFCSASDILGFRAIEHLRRAKEiglrny 1021
Cdd:pfam03177  145 LDLTLLWFKDLFAPN-------------------TRGGSIEPDATLLQEICGSFCSLTDVLGFSAIERLRWAKE------ 199
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392    1022 dSLNYHLKNATALLEQIVDD---------LSIEKLKEAVSMMLSVNYYPKSIEFLLNIANSMDKgklacqyvANGFLEND 1092
Cdd:pfam03177  200 -QLDPKLQNAGKLLEEAYDSdrkwqifklASIGKLEEAIELAEKLRDYPALVELLLEIANQLED--------KAPDSGDD 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392    1093 DRKQYYDKRilvydlvfdtlikvdelaekkqssktqnqisisndDEVKLRQKSYeaaLKYNDRLFHYHMYDWLVSQNREE 1172
Cdd:pfam03177  271 ERKEYYNRA-----------------------------------EELDKRISLY---FERFGELFAYAFYDWLISQGQVE 312
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392    1173 KLLDI--ETPFILPYLMEKAGsslkISNILWVYYS-RRSKFFESAEILYRLATSNFDITLFERIEfLSRANGF--CNSVS 1247
Cdd:pfam03177  313 RLLDFkdNTPFITPFLREKPE----YAKLSWINDVtKEKDYDHAAEILYSLALSQEQDVWSKRIE-LSLAKLAllAELEE 387
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392    1248 PLSQKQRIVQLASRIQDACEVAGIQGDILSLVY-----------------------TDAR--IDSAIKDELIKTLDGKIL 1302
Cdd:pfam03177  388 SDTPDVGLETDLERIDDLLEVINIQDDLYSLILpsiqgaidekaevqlameqfgnvLDDRpaLRQLLKDGLKKLLKHKIL 467
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392    1303 STSELFNDFA----------VPLSYHEIALFIFKIADFRDHE------------VIMAKWDELfqslrmefNNTGKKEDs 1360
Cdd:pfam03177  468 DASDLIDLLTlmdlrpgedeDPLGYFYLALRVLKLSDLRNEDedalerliwrrcMIRDDWEEL--------NDTLKKED- 538
                          650       660       670
                   ....*....|....*....|....*....|..
gi 6319392    1361 mnfinllsnvlIKIGKNVQDSEFIFPIFELFP 1392
Cdd:pfam03177  539 -----------AEVEAQLRSTALYFTLSECFK 559
 
Name Accession Description Interval E-value
NUP170 COG5308
Nuclear pore complex subunit [Intracellular trafficking and secretion];
83-1496 0e+00

Nuclear pore complex subunit [Intracellular trafficking and secretion];


Pssm-ID: 227624 [Multi-domain]  Cd Length: 1263  Bit Score: 1754.08  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392    83 MSNMNEHIRVSGMGTSKPLDLAGKYIDHLQHKDSNTPVLDERSYYNSGVDYNFSREKNglgaFTPFEKQDVFNIPDEILH 162
Cdd:COG5308    1 MRQEGPHVGVSGMGYYELLLLALHWIGMLLKRDTKTPSLDEAKYYEEGLDYIFSIETG----FTPFYAQQVMNIPDRILS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   163 EFSTSQTKTDMGIFPELNRCWITIDNKLILWNINNDNEYQVVDDMKHTIQKVALVRPKPNTFVPAVKHLLLISTTMELFM 242
Cdd:COG5308   77 QISRTEYKTDMGIFPELNRCWITNDNKLILWNYNNSNEYQEIDDFSHTILKVKLVRPKANTFVSRISHLLFVATEKEVMI 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   243 FAISLDKATNELSVFNTHLSVPVQGIDVIDIVSHErSGRIFFAGQAsGLNIWELHYSGSDDWFNSKCSKVCLTKSALLSL 322
Cdd:COG5308  157 LGVSKDTKTGELSLFNTGLVVSVQGINVRCIVSEE-DGRIFFGGEN-DPNVYELVYKSSDSWFNSKCSKICLTKSILSSL 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   323 LPTNMLSQIPGvdfiqalfednsngnggfsqETITQLTIDQQRGIIYSLSSKSTIRAYVITEKSLEGPMSIEPAYISRII 402
Cdd:COG5308  235 LPSFFSFGIPG--------------------ETIKQLAVDQSRGLLYVLRKKSAVRAYSITKNGLVGPVFISFASIDRNA 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   403 GTTTArAAPILGPKYLKIVKISSVAPEENNNLFLVALTVGGVRLYFNGSMGRFNIEALRLESIKFPPSSVTPEViqqell 482
Cdd:COG5308  295 AILNA-TSPLLEPRMYKIVKIVSIPAYENNQLFLVAITSTGCRLYFDGSRGRVSIVALKLDSVKFPPPSTLMQL------ 367
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   483 hqqqEQAKRSFPFFSNLMSSEPVLLKFQKKSSVLLETTKASTIISPGIFFSAVIKSSQqTHQQEKkenssvtGTTATAGS 562
Cdd:COG5308  368 ----EQNKGSRDFYENLFLDRLVMLKRQPNSSDMTETTEMSTIISPGIYFSAVNKRYD-SSNTNK-------GSTVTAIS 435
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   563 KTVKQqpvtlqHKLFVSVPDYGILKTHgKYVENATFLETAGPVQQIIPLSGLFNATTKPQGfanEFATQYTSETLRVAVL 642
Cdd:COG5308  436 LNVDQ------HKLWVSIPDYGILKSS-KYVENVVFLDDIELIQNIDPRTELFNQTNTPQA---TFALLYGNEKLFVAVL 505
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   643 TSTSIEIYKYRTPDEIFEDLIDNPLPFVLNYGAAEACSTALFVTCKSNKSEKLRSNALTFLTMGIPGVVDIKPVYNRYSV 722
Cdd:COG5308  506 TSVEKEIYSYRTPDEIFSGLIGNPLPFYKSYGEAEACSTALLYYCKLNKSEDVGSLALLFLKLGIPDVVDIKPKYYRYSG 585
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   723 StvssllsKPTLStattnlqQSItgFSKPSpankedfDLDDVILSPRFYGIALLITRLLRDIWGRHVFMTftdnrvtsha 802
Cdd:COG5308  586 S-------VPILS-------QSR--FNKPS-------SLDFVRLSPRFYGLALLITRLERNIWLERVFSK---------- 632
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   803 fisssdpitpsinnLKSDEISQNRNIIskvsisKDCIEYYLSSINILNEFFITYGDSISQISAPyvLANNsngrvidktE 882
Cdd:COG5308  633 --------------MQNKMINIRGASI------KIKIEYYLSGIDFLDEFLENNKSSIEGLNSP--LISN---------D 681
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   883 EVANQAESIAINAMIKMVQSIKEGLSFLNVLYEEsevegfdnQYLGFKDIISFVSLDVQKDLVKLDFKDLFAPNdKTKSL 962
Cdd:COG5308  682 EIAVQAESIANNALLLEYQSIKEGLSLLNVLYED--------GVSDFHEIVSSTSIDIQKSCSNLTFSELFTPN-KTKKL 752
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392   963 IREILLSIINRNITKGASIEYTATALQERCGSFCSASDILGFRAIEHLRRAKEIGlRNYDSLNYHLKNATALLEQIVDDL 1042
Cdd:COG5308  753 IKEILKSLVNRNIQSGGSIEYLIKTLSERCGSFCSAEDVLYFRALEHLNKAKSRE-VDLESLNNHLKNAVQLNESLVAKY 831
                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392  1043 SIEKLKEAVSMMLSVNYYPKSIEFLLNIANSMDKGKLACQYVANGFLENDDRKQYYDKRILVYDLVFDTLIKVDELAEkk 1122
Cdd:COG5308  832 NEEGLRYAVTTMISLNYYPKAVNFLLEYAVEIDKGNQACAYVLNGLAENDPRKDFYDKRIKVYSLIFEILISVDKENS-- 909
                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392  1123 qssktqnqisisnDDEVKLRQKSYEAALKYNDRLFHYHMYDWLVSQNREEKLLDIETPFILPYLMEKAGSSLKISNILWV 1202
Cdd:COG5308  910 -------------LRNSELKCCVYPSAMGSNDRLFHYCFYDWLVFKGRTDRLIKIDSPFILPYLKEKAMSSLKISNLLWK 976
                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392  1203 YYSRRSKFFESAEILYRLATSNFDITLFERIEFLSRANGFCNSVSPLSQKQRIVQLASRIQDACEVAGIQGDILSLVYTD 1282
Cdd:COG5308  977 YYVKREDFVEAAQVLYELATSNFDVSLEERIELLRRANGFCSSHVPNSQKHVNVQLFNEVKERLEVASIQDDILRLVRVD 1056
                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392  1283 ARIDSAIKDELIKTLDGKILSTSELFNDFAVPLSYHEIALFIFKIADFRDHEVIMAKWDELFQSLRMEFNNTGKKEDSMN 1362
Cdd:COG5308 1057 PRIDNNKREELSKQLDGEILSLSELFNDYADPLKYPEIALKIFKISDYRDKAVIRELWEELMSSHENAIISPVGSSDFES 1136
                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392  1363 FINLLSNVLIKIGKnvqdSEFIFPIFELFPIVCNFFYEtlpKEHIVSGSIVSIFITAGVSFNKMYYILKELIETSDSDNS 1442
Cdd:COG5308 1137 FVSFLSNLLIKISK----SENVFPIMDLNDIVGDIFCD---KEMAAGGSVGSAFLSAGVSHLKVYYILEELIEQSKDRLF 1209
                       1370      1380      1390      1400      1410
                 ....*....|....*....|....*....|....*....|....*....|....
gi 6319392  1443 VFNKEMTWLIHEWYKSDRKFRDIISYNDIIHLKEYKIDNDPIEKYVKNSGNNLG 1496
Cdd:COG5308 1210 FLIKEMTWLIKEWYHSDMSFRARILLEDIKKLKNYNEFYDPVEKYCKRKYGILD 1263
Nucleoporin_C pfam03177
Non-repetitive/WGA-negative nucleoporin C-terminal; This is the C-termainl half of a family of ...
832-1392 1.67e-103

Non-repetitive/WGA-negative nucleoporin C-terminal; This is the C-termainl half of a family of nucleoporin proteins. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells, and mediate bidirectional nucleocytoplasmic transport, especially of mRNA and proteins. Two nucleoporin classes are known: one is characterized by the FG repeat pfam03093; the other is represented by this family, and lacks any repeats. RNA undergoing nuclear export first encounters the basket of the nuclear pore and many nucleoporins are accessible on the basket side of the pore.


Pssm-ID: 427181  Cd Length: 559  Bit Score: 342.37  E-value: 1.67e-103
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392     832 VSISKDCIEYYLSSINILNEFFITYGDSISQisapyvlannsngrviDKTEEVANQAESIA------------------- 892
Cdd:pfam03177    1 LASLEQNLELRLSALDDLAEFLKSNGVSIDR----------------DTRWELLWQAEKIAaatalwkkheaflaerpek 64
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392     893 ---INAMIKMVQSIKEGLSFLNVLYEESEV--------EGFDNQYLGFKDI--------------------ISFVSLDVQ 941
Cdd:pfam03177   65 rtlLNSIIKLINSMKEALSFLNVLYEANEIslaaleeaFGFRDENAAFYGIgdelledgieglpepwtstsYIYSNLKRQ 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392     942 KDLVKLDFKDLFAPNdktkslireillsiinrniTKGASIEYTATALQERCGSFCSASDILGFRAIEHLRRAKEiglrny 1021
Cdd:pfam03177  145 LDLTLLWFKDLFAPN-------------------TRGGSIEPDATLLQEICGSFCSLTDVLGFSAIERLRWAKE------ 199
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392    1022 dSLNYHLKNATALLEQIVDD---------LSIEKLKEAVSMMLSVNYYPKSIEFLLNIANSMDKgklacqyvANGFLEND 1092
Cdd:pfam03177  200 -QLDPKLQNAGKLLEEAYDSdrkwqifklASIGKLEEAIELAEKLRDYPALVELLLEIANQLED--------KAPDSGDD 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392    1093 DRKQYYDKRilvydlvfdtlikvdelaekkqssktqnqisisndDEVKLRQKSYeaaLKYNDRLFHYHMYDWLVSQNREE 1172
Cdd:pfam03177  271 ERKEYYNRA-----------------------------------EELDKRISLY---FERFGELFAYAFYDWLISQGQVE 312
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392    1173 KLLDI--ETPFILPYLMEKAGsslkISNILWVYYS-RRSKFFESAEILYRLATSNFDITLFERIEfLSRANGF--CNSVS 1247
Cdd:pfam03177  313 RLLDFkdNTPFITPFLREKPE----YAKLSWINDVtKEKDYDHAAEILYSLALSQEQDVWSKRIE-LSLAKLAllAELEE 387
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392    1248 PLSQKQRIVQLASRIQDACEVAGIQGDILSLVY-----------------------TDAR--IDSAIKDELIKTLDGKIL 1302
Cdd:pfam03177  388 SDTPDVGLETDLERIDDLLEVINIQDDLYSLILpsiqgaidekaevqlameqfgnvLDDRpaLRQLLKDGLKKLLKHKIL 467
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392    1303 STSELFNDFA----------VPLSYHEIALFIFKIADFRDHE------------VIMAKWDELfqslrmefNNTGKKEDs 1360
Cdd:pfam03177  468 DASDLIDLLTlmdlrpgedeDPLGYFYLALRVLKLSDLRNEDedalerliwrrcMIRDDWEEL--------NDTLKKED- 538
                          650       660       670
                   ....*....|....*....|....*....|..
gi 6319392    1361 mnfinllsnvlIKIGKNVQDSEFIFPIFELFP 1392
Cdd:pfam03177  539 -----------AEVEAQLRSTALYFTLSECFK 559
Nucleoporin_N pfam08801
Nup133 N terminal like; Nup133 is a nucleoporin that is crucial for nuclear pore complex (NPC) ...
144-649 1.03e-98

Nup133 N terminal like; Nup133 is a nucleoporin that is crucial for nuclear pore complex (NPC) biogenesis. The N terminal forms a seven-bladed beta propeller structure. This family now contains other sized nucleoporins, including Nup155, Nup8, Nuo132, Nup15 and Nup170.


Pssm-ID: 400932  Cd Length: 426  Bit Score: 323.96  E-value: 1.03e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392     144 AFTPFEKQ-DVFNIPDEILHEFSTSQTKTDMGIFPELNRCWITIDNKLILWNINN-----DNEYQVVDDMKHTIQKVA-L 216
Cdd:pfam08801    1 TENDFYKVsKLPPLPDEVLEELSFAEAPTKGGVFPEIGRAWITVDNKLFIWNYNStasspLTDTIPLDEESHTILPVGpL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392     217 VRPKPNTFVPAVKHLLLISTTMELFMFAISLDKA----TNELSVFNTHLSVPVQGIDVIDIVSHERSGRIFFAGqASGlN 292
Cdd:pfam08801   81 VKPKPGTFVPEPGLVLVVATTGDIVYWESISSAGallsLNELQGLETDLSVLSDGEYVTDLVNSEPAGRIFLAG-STG-R 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392     293 IWELHYSGSDDWFNSKCSKVCLTKSALLSLlptNMLSQIPGvdfiqalfednsngnGGFSQETITQLTIDQQRG--IIYS 370
Cdd:pfam08801  159 LYELTYRDSSGKPSLKCRKIRSPSGGFSSL---SIIPSVFG---------------GGSEREEIVSLRVDPSRGerLLYT 220
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392     371 LSSKSTIRAYVIT---EKSLEGPMSIEPAYISRIigttTARAAPILGPKYLKIVKISSVAPEENNNLFLVALTVGGVRLY 447
Cdd:pfam08801  221 LTSKGVIQVWDLSssgGSDLKSDADIRQIILEAI----SLISTAPLASKSLKILDISPIDSDESSLLHLVAITSNGVRLY 296
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392     448 FNGSMGRFN-IEALRLESIKFPPssvtpeviqqellhqqqeqakRSFPFFSNLMSSepvllkfQKKSSVLLETtkastiI 526
Cdd:pfam08801  297 YLLSTILLDsPSVLSLSSVRFPP---------------------RLNTYSSKLLEG-------KKKPRLLIPS------Y 342
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319392     527 SPGIFFSAVIKSSqqthqqekkenssvtgttatagsktvkqqpvtlqhKLFVSVPDYGIlkTHGKYVENATFLETAGPVQ 606
Cdd:pfam08801  343 SPGTFLFVVFDSS-----------------------------------VVLVSLSDYGF--PHGKLVEDTSFYPLDGPWE 385
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|...
gi 6319392     607 QIIPLSGLFNATTKPQGFANEFATQYTSetLRVAVLTSTSIEI 649
Cdd:pfam08801  386 DIISLRPVLDATILGSGYENVSASQYSP--AKFVLLTNFGVVI 426
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH