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Conserved domains on  [gi|6319491|ref|NP_009573|]
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Kap104p [Saccharomyces cerevisiae S288C]

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 10607647)

HEAT repeat domain-containing protein similar to Saccharomyces cerevisiae importin subunit beta-2, also called karyopherin-104, that functions as a nuclear transport receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 435-489 8.90e-14

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


:

Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 66.62  E-value: 8.90e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 6319491    435 WFIREATILALGAMAEGGMKYFNDGLPALIPFLVEQLNDKWAPVRKMTCWTLSRF 489
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
422-542 5.06e-06

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.93  E-value: 5.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319491  422 AFPFLREHLGSDRWFIREATILALGAMaeggmkyfndGLPALIPFLVEQLNDKWAPVRKMTCWTLSRFSPWilqdhtefl 501
Cdd:COG1413  17 AVPALIAALADEDPDVRAAAARALGRL----------GDPRAVPALLEALKDPDPEVRAAAAEALGRIGDP--------- 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 6319491  502 iPVLEPIINTLMDKKKDVQEAAISSVAVF-IENADSELVETL 542
Cdd:COG1413  78 -EAVPALIAALKDEDPEVRRAAAEALGRLgDPAAVPALLEAL 118
 
Name Accession Description Interval E-value
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 435-489 8.90e-14

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 66.62  E-value: 8.90e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 6319491    435 WFIREATILALGAMAEGGMKYFNDGLPALIPFLVEQLNDKWAPVRKMTCWTLSRF 489
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
422-542 5.06e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.93  E-value: 5.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319491  422 AFPFLREHLGSDRWFIREATILALGAMaeggmkyfndGLPALIPFLVEQLNDKWAPVRKMTCWTLSRFSPWilqdhtefl 501
Cdd:COG1413  17 AVPALIAALADEDPDVRAAAARALGRL----------GDPRAVPALLEALKDPDPEVRAAAAEALGRIGDP--------- 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 6319491  502 iPVLEPIINTLMDKKKDVQEAAISSVAVF-IENADSELVETL 542
Cdd:COG1413  78 -EAVPALIAALKDEDPEVRRAAAEALGRLgDPAAVPALLEAL 118
HEAT COG1413
HEAT repeat [General function prediction only];
422-526 4.65e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 44.23  E-value: 4.65e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319491  422 AFPFLREHLGSDRWFIREATILALGAMaeggmkyfndGLPALIPFLVEQLNDKWAPVRKMTCWTLSRFSPwilqdhtefl 501
Cdd:COG1413  48 AVPALLEALKDPDPEVRAAAAEALGRI----------GDPEAVPALIAALKDEDPEVRRAAAEALGRLGD---------- 107

                        90       100
                ....*....|....*....|....*
gi 6319491  502 IPVLEPIINTLMDKKKDVQEAAISS 526
Cdd:COG1413 108 PAAVPALLEALKDPDWEVRRAAARA 132
 
Name Accession Description Interval E-value
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 435-489 8.90e-14

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 66.62  E-value: 8.90e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 6319491    435 WFIREATILALGAMAEGGMKYFNDGLPALIPFLVEQLNDKWAPVRKMTCWTLSRF 489
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
422-542 5.06e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 46.93  E-value: 5.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319491  422 AFPFLREHLGSDRWFIREATILALGAMaeggmkyfndGLPALIPFLVEQLNDKWAPVRKMTCWTLSRFSPWilqdhtefl 501
Cdd:COG1413  17 AVPALIAALADEDPDVRAAAARALGRL----------GDPRAVPALLEALKDPDPEVRAAAAEALGRIGDP--------- 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 6319491  502 iPVLEPIINTLMDKKKDVQEAAISSVAVF-IENADSELVETL 542
Cdd:COG1413  78 -EAVPALIAALKDEDPEVRRAAAEALGRLgDPAAVPALLEAL 118
HEAT COG1413
HEAT repeat [General function prediction only];
422-526 4.65e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 44.23  E-value: 4.65e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319491  422 AFPFLREHLGSDRWFIREATILALGAMaeggmkyfndGLPALIPFLVEQLNDKWAPVRKMTCWTLSRFSPwilqdhtefl 501
Cdd:COG1413  48 AVPALLEALKDPDPEVRAAAAEALGRI----------GDPEAVPALIAALKDEDPEVRRAAAEALGRLGD---------- 107

                        90       100
                ....*....|....*....|....*
gi 6319491  502 IPVLEPIINTLMDKKKDVQEAAISS 526
Cdd:COG1413 108 PAAVPALLEALKDPDWEVRRAAARA 132
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 422-480 1.16e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 38.86  E-value: 1.16e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 6319491    422 AFPFLREHLGSDRWFIREATILALGAMaeggmkyfndGLPALIPFLVEQLNDKWAPVRK 480
Cdd:pfam13646  32 AVPALLELLKDEDPAVRRAAAEALGKI----------GDPEALPALLELLRDDDDDVVR 80
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
397-490 2.23e-03

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 41.85  E-value: 2.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319491  397 WNLRKCSAATLDVMTNILPHQVMDIAFPFLREHLGSDRWFIREATILALGAMAEGG-----MKYFNDGLPALIpflvEQL 471
Cdd:COG5215 342 WNPSMAASSCLQLFAQLKGDKIMRPVLGFVEQNIRSESWANREAAVMAFGSVMHGPcedclTKIVPQALPGIE----NEM 417

                        90
                ....*....|....*....
gi 6319491  472 NDKWAPVRKMTCWTLSRFS 490
Cdd:COG5215 418 SDSCLWVKSTTAWCFGAIA 436
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 424-528 4.43e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 37.32  E-value: 4.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319491    424 PFLREHLGSDR-WFIREATILALGAMaeggmkyfndGLPALIPFLVEQLNDKWAPVRKMTCWTLSRFSpwilqdhTEFLI 502
Cdd:pfam13646   2 PALLQALLRDPdPEVRAAAIRALGRI----------GDPEAVPALLELLKDEDPAVRRAAAEALGKIG-------DPEAL 64

                          90       100
                  ....*....|....*....|....*.
gi 6319491    503 PVLEPIINTlmDKKKDVQEAAISSVA 528
Cdd:pfam13646  65 PALLELLRD--DDDDVVRAAAAEALA 88
HEAT COG1413
HEAT repeat [General function prediction only];
437-605 5.37e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 38.07  E-value: 5.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319491  437 IREATILALGAMaeggmkyfndGLPALIPFLVEQLNDKWAPVRKMTCWTLSRfspwiLQDhteflIPVLEPIINTLMDKK 516
Cdd:COG1413   1 VRRAAARALGRL----------GDPAAVPALIAALADEDPDVRAAAARALGR-----LGD-----PRAVPALLEALKDPD 60

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319491  517 KDVQEAAISSVAvfiENADSELVETLfysqlltsfdkcLKYYKKKNLIILYDAIGrfaekcALDETAMQIILPPLIEkwa 596
Cdd:COG1413  61 PEVRAAAAEALG---RIGDPEAVPAL------------IAALKDEDPEVRRAAAE------ALGRLGDPAAVPALLE--- 116


                ....*....
gi 6319491  597 LLSDSDKEL 605
Cdd:COG1413 117 ALKDPDWEV 125
HEAT COG1413
HEAT repeat [General function prediction only];
422-488 6.68e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 37.69  E-value: 6.68e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6319491  422 AFPFLREHLGSDRWFIREATILALGAMaeggmkyfndGLPALIPFLVEQLNDKWAPVRKMTCWTLSR 488
Cdd:COG1413  79 AVPALIAALKDEDPEVRRAAAEALGRL----------GDPAAVPALLEALKDPDWEVRRAAARALGR 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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