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Conserved domains on  [gi|330443437|ref|NP_009632|]
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Ecm8p [Saccharomyces cerevisiae S288C]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rua1_C super family cl20590
Transcription regulator Rua1, C-terminal; This entry represents a domain that can be found at ...
 164-282 2.81e-05

Transcription regulator Rua1, C-terminal; This entry represents a domain that can be found at the C terminus f fungal proteins such as meiotic expression up-regulated protein 26 from Schizosaccharomyces pombe, Ecm8 from Saccharomyces cerevisiae and Rua1 from Ustilago maydis. Rua1 is a transcription factor and part of the gene cluster that mediates the biosynthesis of the glycolipid biosurfactant ustilagic acid (UA).


The actual alignment was detected with superfamily member pfam14616:

Pssm-ID: 405322  Cd Length: 120  Bit Score: 43.17  E-value: 2.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443437  164 YKYMRYSEKKKELMCRFCQGNN----WILAEN--YLKHLFFAHGILSefkphtlyhfeskllkiqgklnfkiqvlkepef 237
Cdd:pfam14616  12 VRGEKDKGEKKEGLCPYCEEPEgkevFLPLKNsaYLYHLSFSHGVSS--------------------------------- 58

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 330443437  238 skkilnslTVSIIPSPLAYYTQ--TLNGGFRRIHVKCPHCENWIRLG 282
Cdd:pfam14616  59 --------NGLPFPPPISFRTVrrTKAKNRERLGIICPKCNKWIEVQ 97
beta-trefoil_Ricin-like super family cl49609
ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a ...
 261-342 1.37e-04

ricin B-type lectin domain, beta-trefoil fold; The ricin B-type lectin domain is a carbohydrate-binding domain formed from presumed gene triplication. It shows a beta-trefoil fold characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry. The ricin B-type lectin domain was originally found in Ricin, which is a legume lectin from the seeds of the castor bean plant, Ricinus communis. It is also found in many carbohydrate-recognition proteins like plant and bacterial AB-toxins, glycosidases, or proteases, which serve diverse functions such as inhibitory toxicity, enzymatic activity, and signal transduction. The ricin B-type lectin domain can be present in one or more copies and has been shown in some instances to bind simple sugars, such as galactose or lactose. The most characteristic, though not completely conserved, sequence feature is the presence of a Q-W pattern. Consequently, the ricin B-type lectin domain has also been referred as the (QxW)3 domain and the three homologous regions as the QxW repeats. A disulfide bond is also conserved in some QxW repeats.


The actual alignment was detected with superfamily member pfam03498:

Pssm-ID: 483949  Cd Length: 149  Bit Score: 41.70  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443437  261 LNGGFrrIHVKCPHCENWIRLGWcEYDEIirDSfQDFESLRNLNADYNGMSYIQTRNREDIE--GIYENYFTHYIQCDLA 338
Cdd:pfam03498   8 LTGAL--LTNWALDSRNWLSTNW-GYTPI--DS-NEFGLLRDKIMDGKNGGTVQFKNPDTGTclAAYGNGVIHLKACDDD 81


                  ....
gi 330443437  339 TFRT 342
Cdd:pfam03498  82 DLAT 85
 
Name Accession Description Interval E-value
Rua1_C pfam14616
Transcription regulator Rua1, C-terminal; This entry represents a domain that can be found at ...
 164-282 2.81e-05

Transcription regulator Rua1, C-terminal; This entry represents a domain that can be found at the C terminus f fungal proteins such as meiotic expression up-regulated protein 26 from Schizosaccharomyces pombe, Ecm8 from Saccharomyces cerevisiae and Rua1 from Ustilago maydis. Rua1 is a transcription factor and part of the gene cluster that mediates the biosynthesis of the glycolipid biosurfactant ustilagic acid (UA).


Pssm-ID: 405322  Cd Length: 120  Bit Score: 43.17  E-value: 2.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443437  164 YKYMRYSEKKKELMCRFCQGNN----WILAEN--YLKHLFFAHGILSefkphtlyhfeskllkiqgklnfkiqvlkepef 237
Cdd:pfam14616  12 VRGEKDKGEKKEGLCPYCEEPEgkevFLPLKNsaYLYHLSFSHGVSS--------------------------------- 58

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 330443437  238 skkilnslTVSIIPSPLAYYTQ--TLNGGFRRIHVKCPHCENWIRLG 282
Cdd:pfam14616  59 --------NGLPFPPPISFRTVrrTKAKNRERLGIICPKCNKWIEVQ 97
CDtoxinA pfam03498
Cytolethal distending toxin A/C domain;
261-342 1.37e-04

Cytolethal distending toxin A/C domain;


Pssm-ID: 397529  Cd Length: 149  Bit Score: 41.70  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443437  261 LNGGFrrIHVKCPHCENWIRLGWcEYDEIirDSfQDFESLRNLNADYNGMSYIQTRNREDIE--GIYENYFTHYIQCDLA 338
Cdd:pfam03498   8 LTGAL--LTNWALDSRNWLSTNW-GYTPI--DS-NEFGLLRDKIMDGKNGGTVQFKNPDTGTclAAYGNGVIHLKACDDD 81


                  ....
gi 330443437  339 TFRT 342
Cdd:pfam03498  82 DLAT 85
 
Name Accession Description Interval E-value
Rua1_C pfam14616
Transcription regulator Rua1, C-terminal; This entry represents a domain that can be found at ...
 164-282 2.81e-05

Transcription regulator Rua1, C-terminal; This entry represents a domain that can be found at the C terminus f fungal proteins such as meiotic expression up-regulated protein 26 from Schizosaccharomyces pombe, Ecm8 from Saccharomyces cerevisiae and Rua1 from Ustilago maydis. Rua1 is a transcription factor and part of the gene cluster that mediates the biosynthesis of the glycolipid biosurfactant ustilagic acid (UA).


Pssm-ID: 405322  Cd Length: 120  Bit Score: 43.17  E-value: 2.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443437  164 YKYMRYSEKKKELMCRFCQGNN----WILAEN--YLKHLFFAHGILSefkphtlyhfeskllkiqgklnfkiqvlkepef 237
Cdd:pfam14616  12 VRGEKDKGEKKEGLCPYCEEPEgkevFLPLKNsaYLYHLSFSHGVSS--------------------------------- 58

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 330443437  238 skkilnslTVSIIPSPLAYYTQ--TLNGGFRRIHVKCPHCENWIRLG 282
Cdd:pfam14616  59 --------NGLPFPPPISFRTVrrTKAKNRERLGIICPKCNKWIEVQ 97
CDtoxinA pfam03498
Cytolethal distending toxin A/C domain;
261-342 1.37e-04

Cytolethal distending toxin A/C domain;


Pssm-ID: 397529  Cd Length: 149  Bit Score: 41.70  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443437  261 LNGGFrrIHVKCPHCENWIRLGWcEYDEIirDSfQDFESLRNLNADYNGMSYIQTRNREDIE--GIYENYFTHYIQCDLA 338
Cdd:pfam03498   8 LTGAL--LTNWALDSRNWLSTNW-GYTPI--DS-NEFGLLRDKIMDGKNGGTVQFKNPDTGTclAAYGNGVIHLKACDDD 81


                  ....
gi 330443437  339 TFRT 342
Cdd:pfam03498  82 DLAT 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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