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Conserved domains on  [gi|6319553|ref|NP_009635|]
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translation initiation factor eIF3 core subunit a [Saccharomyces cerevisiae S288C]

Protein Classification

PCI domain-containing protein; UBX domain-containing protein( domain architecture ID 13888495)

PCI (proteasome-COP9/CSN-initiation factor) domain-containing protein is a component of multiprotein complexes; similar to eukaryotic translation initiation factor 3 subunits A and M, and Schizosaccharomyces pombe Cop9 signalosome complex subunit 4| UBX domain-containing protein similar to NSFL1 cofactor p47, which is a major cofactor of the cytosolic AAA ATPase p97 and is required for the p97-regulated membrane reassembly of the endoplasmic reticulum (ER), the nuclear envelope and the Golgi apparatus

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF5401 super family cl38662
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 595-862 1.19e-11

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


The actual alignment was detected with superfamily member pfam17380:

Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 68.61  E-value: 1.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    595 EKISKIVDERVKRSQEQKQKHMEH-----AALHAEQDAEVRQQRILEEKAAIEAKLEEEAHRRLIEKKKREFEAIKEREI 669
Cdd:pfam17380 291 EKFEKMEQERLRQEKEEKAREVERrrkleEAEKARQAEMDRQAAIYAEQERMAMERERELERIRQEERKRELERIRQEEI 370

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    670 TKMITEVNAKGHVYID---PNEAKSLDLDTIKQVIIAEVSKNKSELESRMEyaMKKLDHTERALRKVELPLLQKEVDKLQ 746
Cdd:pfam17380 371 AMEISRMRELERLQMErqqKNERVRQELEAARKVKILEEERQRKIQQQKVE--MEQIRAEQEEARQREVRRLEEERAREM 448

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    747 ETDTANYEAMKKKIVDAAKAEYEARmadRKNLVMVYDDylkfkehvsgtKESELAAIRNQK--KAELEAAKKARIEEVRK 824
Cdd:pfam17380 449 ERVRLEEQERQQQVERLRQQEEERK---RKKLELEKEK-----------RDRKRAEEQRRKilEKELEERKQAMIEEERK 514

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 6319553    825 RR-YEEAIARRKEEIANAERQKRAQelaEATRKQREIEE 862
Cdd:pfam17380 515 RKlLEKEMEERQKAIYEEERRREAE---EERRKQQEMEE 550
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 419-495 1.12e-07

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


:

Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 50.32  E-value: 1.12e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6319553     419 QYIAPLRDVIMRRVFVAASQKFTTVSQSELYKLATLPAPldlsawDIEKSLLQAAVEDYVSITIDHESAKVTFAKDP 495
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVP------EVEKLVSKAIRDGEISAKIDQVNGIVEFEEVD 71
 
Name Accession Description Interval E-value
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 595-862 1.19e-11

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 68.61  E-value: 1.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    595 EKISKIVDERVKRSQEQKQKHMEH-----AALHAEQDAEVRQQRILEEKAAIEAKLEEEAHRRLIEKKKREFEAIKEREI 669
Cdd:pfam17380 291 EKFEKMEQERLRQEKEEKAREVERrrkleEAEKARQAEMDRQAAIYAEQERMAMERERELERIRQEERKRELERIRQEEI 370

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    670 TKMITEVNAKGHVYID---PNEAKSLDLDTIKQVIIAEVSKNKSELESRMEyaMKKLDHTERALRKVELPLLQKEVDKLQ 746
Cdd:pfam17380 371 AMEISRMRELERLQMErqqKNERVRQELEAARKVKILEEERQRKIQQQKVE--MEQIRAEQEEARQREVRRLEEERAREM 448

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    747 ETDTANYEAMKKKIVDAAKAEYEARmadRKNLVMVYDDylkfkehvsgtKESELAAIRNQK--KAELEAAKKARIEEVRK 824
Cdd:pfam17380 449 ERVRLEEQERQQQVERLRQQEEERK---RKKLELEKEK-----------RDRKRAEEQRRKilEKELEERKQAMIEEERK 514

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 6319553    825 RR-YEEAIARRKEEIANAERQKRAQelaEATRKQREIEE 862
Cdd:pfam17380 515 RKlLEKEMEERQKAIYEEERRREAE---EERRKQQEMEE 550
PTZ00121 PTZ00121
MAEBL; Provisional
 588-868 1.75e-11

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 68.63  E-value: 1.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    588 KKNKDDLEKIS---KIVDERVKRSQEQKQKHME-HAALHAEQDAEVRQQRILEEKAAIEAKLEEEAHRRLIEKKKREFEA 663
Cdd:PTZ00121 1377 KKKADAAKKKAeekKKADEAKKKAEEDKKKADElKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEA 1456

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    664 IKEREITKMITEVNAKGHVYIDPNEAKSLDLDTIKqviiAEVSKNKSELESRMEYAMKKLDHTERA--------LRKVEL 735
Cdd:PTZ00121 1457 KKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKK----AEEAKKKADEAKKAAEAKKKADEAKKAeeakkadeAKKAEE 1532

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    736 PLLQKEVDKLQETDTAN----YEAMKK-----KIVDAAKAEYEARMADRK-------------NLVMVYDDYLKFKEHVS 793
Cdd:PTZ00121 1533 AKKADEAKKAEEKKKADelkkAEELKKaeekkKAEEAKKAEEDKNMALRKaeeakkaeearieEVMKLYEEEKKMKAEEA 1612

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    794 GTKESELAAIRNQKKAE-----LEAAKKARIEEVRK----RRYEEAIARRKEEIANA--ERQKRAQELAEATRKQREIEE 862
Cdd:PTZ00121 1613 KKAEEAKIKAEELKKAEeekkkVEQLKKKEAEEKKKaeelKKAEEENKIKAAEEAKKaeEDKKKAEEAKKAEEDEKKAAE 1692


                  ....*.
gi 6319553    863 AAAKKS 868
Cdd:PTZ00121 1693 ALKKEA 1698
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 419-495 1.12e-07

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 50.32  E-value: 1.12e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6319553     419 QYIAPLRDVIMRRVFVAASQKFTTVSQSELYKLATLPAPldlsawDIEKSLLQAAVEDYVSITIDHESAKVTFAKDP 495
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVP------EVEKLVSKAIRDGEISAKIDQVNGIVEFEEVD 71
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 575-868 7.48e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.40  E-value: 7.48e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553  575 YMEKVRIARETLIKKNKDDLEKISKIVDERVKRSQEQKQKHMEHAALHAEQDAEVRQQRiLEEKAAIEAKLEEEahrRLI 654
Cdd:COG1196 218 LKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLEL-EELELELEEAQAEE---YEL 293

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553  655 EKKKREFEAIKEREITKMITEVNAKghvyidpnEAKSLDLDTIKQVIIAEvSKNKSELESRMEYAMKKLDHTERALRKVE 734
Cdd:COG1196 294 LAELARLEQDIARLEERRRELEERL--------EELEEELAELEEELEEL-EEELEELEEELEEAEEELEEAEAELAEAE 364

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553  735 lpLLQKEVDKLQETDTANYEAMKKKIVDAAKAEYEARmADRKNLVMVYDDYLKFKEHVSGTKESELAAIRNQKKAELEAA 814
Cdd:COG1196 365 --EALLEAEAELAEAEEELEELAEELLEALRAAAELA-AQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEE 441

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 6319553  815 KKARIEEVRKRRYEEAIARRKEEIANAERQKRAQELAEATRKQREIEEAAAKKS 868
Cdd:COG1196 442 EALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLL 495
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 583-924 1.12e-04

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 46.37  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    583 RETLIKKNKDDLEKISKIVDERVKRSQEQKQkhMEHAALHAEQD------------AEVRQQRILEEK----AAI---EA 643
Cdd:NF012221 1513 SNRLEFKGTGHNDGLGYILDNVVATSESSQQ--ADAVSKHAKQDdaaqnaladkerAEADRQRLEQEKqqqlAAIsgsQS 1590

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    644 KLEEEAHRRLIEKKKREFEAIKE--REITKMITEVnakghvyidpneAKSLDldtikQVIIAEVSKNKSELESRMEYAMK 721
Cdd:NF012221 1591 QLESTDQNALETNGQAQRDAILEesRAVTKELTTL------------AQGLD-----ALDSQATYAGESGDQWRNPFAGG 1653

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    722 KLDHTERALRKVELpLLQKEVDKLQETDTANYEAMKKKIvdaAKAEYearmadrknlvmvyddylkfkehvsGTKESEla 801
Cdd:NF012221 1654 LLDRVQEQLDDAKK-ISGKQLADAKQRHVDNQQKVKDAV---AKSEA-------------------------GVAQGE-- 1702

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    802 aiRNQKKAELeAAKKARIEEvrKRRYEEAIARRKEEianAERQKRAQELAEATRKQREIEEAAAKKSTpysfragnrepp 881
Cdd:NF012221 1703 --QNQANAEQ-DIDDAKADA--EKRKDDALAKQNEA---QQAESDANAAANDAQSRGEQDASAAENKA------------ 1762

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 6319553    882 stpstlpkatvspDKAKLDMIAQKQREMEEAIEQRLAGRTAGG 924
Cdd:NF012221 1763 -------------NQAQADAKGAKQDESDKPNRQGAAGSGLSG 1792
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 573-861 8.60e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.52  E-value: 8.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553     573 ASYMEKVRIARETL--IKKNKDDLEKISKIVDERVKRSQEQKQKHMEHAALHAE-QDAE----VRQQRILE-EKAAIEAK 644
Cdd:TIGR02169  166 AEFDRKKEKALEELeeVEENIERLDLIIDEKRQQLERLRREREKAERYQALLKEkREYEgyelLKEKEALErQKEAIERQ 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553     645 LEEEahRRLIEKKKREFEAIKER--EITKMITEVNAKghvyIDP-NEAKSLDLDTIKQVIIAEVSK---NKSELESRMEY 718
Cdd:TIGR02169  246 LASL--EEELEKLTEEISELEKRleEIEQLLEELNKK----IKDlGEEEQLRVKEKIGELEAEIASlerSIAEKERELED 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553     719 AMKKLDHTERALRKV---------ELPLLQKEVDKLQE---TDTANYEAMKKKIVDAAKAEYEAR---MADRKNLVMVYD 783
Cdd:TIGR02169  320 AEERLAKLEAEIDKLlaeieelerEIEEERKRRDKLTEeyaELKEELEDLRAELEEVDKEFAETRdelKDYREKLEKLKR 399

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553     784 D------YLKFKEHVSGTKESELAAIRNQ------KKAELEAAKKARIEEVRK--------------------------R 825
Cdd:TIGR02169  400 EinelkrELDRLQEELQRLSEELADLNAAiagieaKINELEEEKEDKALEIKKqewkleqlaadlskyeqelydlkeeyD 479

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 6319553     826 RYEEAIARRKEEIANAERQKRAQELAEATRKQREIE 861
Cdd:TIGR02169  480 RVEKELSKLQRELAEAEAQARASEERVRGGRAVEEV 515
 
Name Accession Description Interval E-value
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 595-862 1.19e-11

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 68.61  E-value: 1.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    595 EKISKIVDERVKRSQEQKQKHMEH-----AALHAEQDAEVRQQRILEEKAAIEAKLEEEAHRRLIEKKKREFEAIKEREI 669
Cdd:pfam17380 291 EKFEKMEQERLRQEKEEKAREVERrrkleEAEKARQAEMDRQAAIYAEQERMAMERERELERIRQEERKRELERIRQEEI 370

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    670 TKMITEVNAKGHVYID---PNEAKSLDLDTIKQVIIAEVSKNKSELESRMEyaMKKLDHTERALRKVELPLLQKEVDKLQ 746
Cdd:pfam17380 371 AMEISRMRELERLQMErqqKNERVRQELEAARKVKILEEERQRKIQQQKVE--MEQIRAEQEEARQREVRRLEEERAREM 448

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    747 ETDTANYEAMKKKIVDAAKAEYEARmadRKNLVMVYDDylkfkehvsgtKESELAAIRNQK--KAELEAAKKARIEEVRK 824
Cdd:pfam17380 449 ERVRLEEQERQQQVERLRQQEEERK---RKKLELEKEK-----------RDRKRAEEQRRKilEKELEERKQAMIEEERK 514

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 6319553    825 RR-YEEAIARRKEEIANAERQKRAQelaEATRKQREIEE 862
Cdd:pfam17380 515 RKlLEKEMEERQKAIYEEERRREAE---EERRKQQEMEE 550
PTZ00121 PTZ00121
MAEBL; Provisional
 588-868 1.75e-11

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 68.63  E-value: 1.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    588 KKNKDDLEKIS---KIVDERVKRSQEQKQKHME-HAALHAEQDAEVRQQRILEEKAAIEAKLEEEAHRRLIEKKKREFEA 663
Cdd:PTZ00121 1377 KKKADAAKKKAeekKKADEAKKKAEEDKKKADElKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEA 1456

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    664 IKEREITKMITEVNAKGHVYIDPNEAKSLDLDTIKqviiAEVSKNKSELESRMEYAMKKLDHTERA--------LRKVEL 735
Cdd:PTZ00121 1457 KKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKK----AEEAKKKADEAKKAAEAKKKADEAKKAeeakkadeAKKAEE 1532

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    736 PLLQKEVDKLQETDTAN----YEAMKK-----KIVDAAKAEYEARMADRK-------------NLVMVYDDYLKFKEHVS 793
Cdd:PTZ00121 1533 AKKADEAKKAEEKKKADelkkAEELKKaeekkKAEEAKKAEEDKNMALRKaeeakkaeearieEVMKLYEEEKKMKAEEA 1612

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    794 GTKESELAAIRNQKKAE-----LEAAKKARIEEVRK----RRYEEAIARRKEEIANA--ERQKRAQELAEATRKQREIEE 862
Cdd:PTZ00121 1613 KKAEEAKIKAEELKKAEeekkkVEQLKKKEAEEKKKaeelKKAEEENKIKAAEEAKKaeEDKKKAEEAKKAEEDEKKAAE 1692


                  ....*.
gi 6319553    863 AAAKKS 868
Cdd:PTZ00121 1693 ALKKEA 1698
PTZ00121 PTZ00121
MAEBL; Provisional
 588-918 3.99e-11

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 67.47  E-value: 3.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    588 KKNKDDLEKIS---KIVDERVKRSQEQKQKHMEHAALHAEQD----AEVRQQRILEEKAAIEAKLEEEAHRRLIEKKKRE 660
Cdd:PTZ00121 1328 KKKADAAKKKAeeaKKAAEAAKAEAEAAADEAEAAEEKAEAAekkkEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKA 1407

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    661 FEAIKEREITKMITEVNAKGHVYIDPNEAKSLDLDTIKqviiAEVSKNKSELESRMEYAMKKldhTERALRKVELPLLQK 740
Cdd:PTZ00121 1408 DELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKK----ADEAKKKAEEAKKAEEAKKK---AEEAKKADEAKKKAE 1480

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    741 EVDKLQETDTANYEAmKKKIVDAAKAEYEARMADrknlvmvyddylKFKEHVSGTKESELAAIRNQKKAEleAAKKAriE 820
Cdd:PTZ00121 1481 EAKKADEAKKKAEEA-KKKADEAKKAAEAKKKAD------------EAKKAEEAKKADEAKKAEEAKKAD--EAKKA--E 1543

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    821 EVRK----RRYEEAiaRRKEEIANAERQKRAQELAEATRKQREIEEAAAKKSTPYSFRAGNREPPSTPSTLPKATVSPDK 896
Cdd:PTZ00121 1544 EKKKadelKKAEEL--KKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIK 1621

                         330       340
                  ....*....|....*....|..
gi 6319553    897 AKLDMIAQKQREMEEAIEQRLA 918
Cdd:PTZ00121 1622 AEELKKAEEEKKKVEQLKKKEA 1643
PTZ00121 PTZ00121
MAEBL; Provisional
 607-867 6.38e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 60.15  E-value: 6.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    607 RSQEQKQKHMEHAALHAEQDAEVRQQRILEEKAAIEAKLE-EEAHRRLIEKKKREFEAIKEREITKMITEVNAKgHVYID 685
Cdd:PTZ00121 1284 KKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKaEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAAD-EAEAA 1362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    686 PNEAKSLDLDTIKQVIIAEVSKNKSELESRMEYAMKKLDHTERALRKV-----------ELPLLQKEVDKLQETDTANYE 754
Cdd:PTZ00121 1363 EEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELkkaaaakkkadEAKKKAEEKKKADEAKKKAEE 1442

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    755 A-----MKKKIVDAAKAEYEARMADRKNLVmvyDDYLKFKEHVSGTKESELAAIRNQKKAE-----LEAAKKA----RIE 820
Cdd:PTZ00121 1443 AkkadeAKKKAEEAKKAEEAKKKAEEAKKA---DEAKKKAEEAKKADEAKKKAEEAKKKADeakkaAEAKKKAdeakKAE 1519

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 6319553    821 EVRK----RRYEEaiARRKEEIANAERQKRAQEL--AEATRKQREIEEAAAKK 867
Cdd:PTZ00121 1520 EAKKadeaKKAEE--AKKADEAKKAEEKKKADELkkAEELKKAEEKKKAEEAK 1570
PTZ00121 PTZ00121
MAEBL; Provisional
 588-911 3.35e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.84  E-value: 3.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    588 KKNKDDLEKIS---KIVDERVKRSQEQKQKhMEHAALHAEQDAEVRQQRILEE-KAAIEAKLEEEAhRRLIEKKKREfEA 663
Cdd:PTZ00121 1469 AKKADEAKKKAeeaKKADEAKKKAEEAKKK-ADEAKKAAEAKKKADEAKKAEEaKKADEAKKAEEA-KKADEAKKAE-EK 1545

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    664 IKEREITKmiTEVNAKGHVYIDPNEAKSLDLDTIKQVIIAEVSKN--KSELESRMEYAMKKLDHTERALRKVELPLLQKE 741
Cdd:PTZ00121 1546 KKADELKK--AEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKaeEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAE 1623

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    742 VDKLQETDTANYEAMKKKIVDAAKAEYEARMADRKNLVMVYDDYLKFKEHVSGTKESELAAIRNQKKAEL---EAAKKAR 818
Cdd:PTZ00121 1624 ELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEAlkkEAEEAKK 1703

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    819 IEEVRKRRYEEaiARRKEEIANAE--RQKRAQELA-EATRKQREIEEAAAKKSTPYSFRAGNREPPSTPSTLPKATVSPD 895
Cdd:PTZ00121 1704 AEELKKKEAEE--KKKAEELKKAEeeNKIKAEEAKkEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVI 1781

                         330
                  ....*....|....*.
gi 6319553    896 KAKLDMIAQKQREMEE 911
Cdd:PTZ00121 1782 EEELDEEDEKRRMEVD 1797
PINT smart00088
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
 419-495 1.12e-07

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


Pssm-ID: 214509 [Multi-domain]  Cd Length: 88  Bit Score: 50.32  E-value: 1.12e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6319553     419 QYIAPLRDVIMRRVFVAASQKFTTVSQSELYKLATLPAPldlsawDIEKSLLQAAVEDYVSITIDHESAKVTFAKDP 495
Cdd:smart00088   1 QLVERLQRKIRLTNLLQLSEPYSSISLSDLAKLLGLSVP------EVEKLVSKAIRDGEISAKIDQVNGIVEFEEVD 71
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 607-868 3.32e-07

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 54.18  E-value: 3.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553   607 RSQEQKQKhmehAALHAEQDAEVRQQRILEEKAAIEAKLEEEAHRRLIEKKKREFEAIKEREITKMITE--VNAKGHVYI 684
Cdd:PRK05035 439 RAIEQEKK----KAEEAKARFEARQARLEREKAAREARHKKAAEARAAKDKDAVAAALARVKAKKAAATqpIVIKAGARP 514

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553   685 DPNEAKSLDLDTIKQVIIAEVSKNKSELESrmeyamKKLDHTERALRKVElplLQKEVDKLQETDTANYEAMKKKIVDAA 764
Cdd:PRK05035 515 DNSAVIAAREARKAQARARQAEKQAAAAAD------PKKAAVAAAIARAK---AKKAAQQAANAEAEEEVDPKKAAVAAA 585

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553   765 KAEYEARMADRKNLVMVYDDYLKFKEHVSGTKESELAAIRNQKKAELEAAKKARIEEVRKRRYEEAIARRKEEIANAERQ 844
Cdd:PRK05035 586 IARAKAKKAAQQAASAEPEEQVAEVDPKKAAVAAAIARAKAKKAEQQANAEPEEPVDPRKAAVAAAIARAKARKAAQQQA 665

                        250       260
                 ....*....|....*....|....*..
gi 6319553   845 KRAQELAEATRKQR---EIEEAAAKKS 868
Cdd:PRK05035 666 NAEPEEAEDPKKAAvaaAIARAKAKKA 692
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 575-868 7.48e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.40  E-value: 7.48e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553  575 YMEKVRIARETLIKKNKDDLEKISKIVDERVKRSQEQKQKHMEHAALHAEQDAEVRQQRiLEEKAAIEAKLEEEahrRLI 654
Cdd:COG1196 218 LKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLEL-EELELELEEAQAEE---YEL 293

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553  655 EKKKREFEAIKEREITKMITEVNAKghvyidpnEAKSLDLDTIKQVIIAEvSKNKSELESRMEYAMKKLDHTERALRKVE 734
Cdd:COG1196 294 LAELARLEQDIARLEERRRELEERL--------EELEEELAELEEELEEL-EEELEELEEELEEAEEELEEAEAELAEAE 364

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553  735 lpLLQKEVDKLQETDTANYEAMKKKIVDAAKAEYEARmADRKNLVMVYDDYLKFKEHVSGTKESELAAIRNQKKAELEAA 814
Cdd:COG1196 365 --EALLEAEAELAEAEEELEELAEELLEALRAAAELA-AQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEE 441

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 6319553  815 KKARIEEVRKRRYEEAIARRKEEIANAERQKRAQELAEATRKQREIEEAAAKKS 868
Cdd:COG1196 442 EALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLL 495
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 798-907 2.26e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 51.69  E-value: 2.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    798 SELAAIRNQ--KKAELEAAKKARIEEVRKRRyeeaiaRRKEEIANAERQKRAQELAEATRKQREIEEAAAKKSTPYSFRA 875
Cdd:pfam03154 583 SKLAKKREEalEKAKREAEQKAREEKEREKE------KEKEREREREREREAERAAKASSSSHEGRMGDPQLAGPAHMRP 656

                          90       100       110
                  ....*....|....*....|....*....|..
gi 6319553    876 GNREPPSTPSTLPkATVSPDKAKLDMIAQKQR 907
Cdd:pfam03154 657 SFEPPPTTIAAVP-PYIGPDTPALRTLSEYAR 687
COG5022 COG5022
Myosin heavy chain [General function prediction only];
579-898 3.31e-06

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 51.23  E-value: 3.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553   579 VRIARETLIKKNKDDLEKISKIVDERvKRSQEQKQKHMEHAA-LHAE-QDAEVRQQRILEEK----AAIEAKLEEEAHRR 652
Cdd:COG5022  805 LLGSRKEYRSYLACIIKLQKTIKREK-KLRETEEVEFSLKAEvLIQKfGRSLKAKKRFSLLKketiYLQSAQRVELAERQ 883

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553   653 LIEKKK--REFEAIKER--EITKMITEVNakghvyidpneaKSLDLDTIKQviiaevSKNKSELESRMEYAMKKLDHTER 728
Cdd:COG5022  884 LQELKIdvKSISSLKLVnlELESEIIELK------------KSLSSDLIEN------LEFKTELIARLKKLLNNIDLEEG 945

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553   729 ALRKVElplLQKEVDKLQETdtanyeamKKKIVDAAKaEYEArMADRKNLVMvyDDYLKFKEHVSGTKeSELAAIRNQKK 808
Cdd:COG5022  946 PSIEYV---KLPELNKLHEV--------ESKLKETSE-EYED-LLKKSTILV--REGNKANSELKNFK-KELAELSKQYG 1009

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553   809 AELEAAKKARIEEVRKRRYEEAIARRKEEIANAERQKRAQEL-----AEATRKQREIEEAAAKKSTPYSFRAGNREPPST 883
Cdd:COG5022 1010 ALQESTKQLKELPVEVAELQSASKIISSESTELSILKPLQKLkglllLENNQLQARYKALKLRRENSLLDDKQLYQLEST 1089

                        330
                 ....*....|....*
gi 6319553   884 PSTLPKATVSPDKAK 898
Cdd:COG5022 1090 ENLLKTINVKDLEVT 1104
PTZ00121 PTZ00121
MAEBL; Provisional
 568-915 8.02e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.14  E-value: 8.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    568 DSFNNASYMEKVRIARETLIKKNKDDLEKISKIVDERVKRSQEQKQKhmehaalhAEQDAEVRQQRILEEKAAIEAKLEE 647
Cdd:PTZ00121 1525 DEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKK--------AEEDKNMALRKAEEAKKAEEARIEE 1596

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    648 EAHRRLIEKKKREFEAIKEREITKMITEVNAKGHVYIDPNEAKSLDLDTIKQViiAEVSKNKSELESRMEYAMKKldhTE 727
Cdd:PTZ00121 1597 VMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKA--EELKKAEEENKIKAAEEAKK---AE 1671

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    728 RALRKVElpllqkEVDKLQETDTANYEAMKKKIVDAAKAEyEARMADRKNLVMVydDYLKFKEHVSGTKESELAAIRNQK 807
Cdd:PTZ00121 1672 EDKKKAE------EAKKAEEDEKKAAEALKKEAEEAKKAE-ELKKKEAEEKKKA--EELKKAEEENKIKAEEAKKEAEED 1742

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    808 KAELEAAKKARIEEVRKRRYEEAIARRKEEIANAERQKRAQELAEATRKQREIEEAAAK--KSTPYSFRAGNREPPSTPS 885
Cdd:PTZ00121 1743 KKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKdiFDNFANIIEGGKEGNLVIN 1822

                         330       340       350
                  ....*....|....*....|....*....|
gi 6319553    886 TLPKATVSPDKAKLDMiAQKQREMEEAIEQ 915
Cdd:PTZ00121 1823 DSKEMEDSAIKEVADS-KNMQLEEADAFEK 1851
PTZ00121 PTZ00121
MAEBL; Provisional
 570-916 3.80e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.83  E-value: 3.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    570 FNNASYMEKVRIARETLIKKNKDDLEKISKIvdERVKRSQEQKQKHmehAALHAEQDAEVRQQRILEEKAAIE-AKLEEE 648
Cdd:PTZ00121 1100 AEEAKKTETGKAEEARKAEEAKKKAEDARKA--EEARKAEDARKAE---EARKAEDAKRVEIARKAEDARKAEeARKAED 1174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    649 AHRrlIEKKKREFEAIKEREITKMiTEVNAKGHVYIDPNEAKsldldtIKQVIIAEVSKnKSELESRMEYAMKKldhtER 728
Cdd:PTZ00121 1175 AKK--AEAARKAEEVRKAEELRKA-EDARKAEAARKAEEERK------AEEARKAEDAK-KAEAVKKAEEAKKD----AE 1240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    729 ALRKVELPLLQKEVDKLQETDTANYEAMKKKIvdaaKAEyEARMADRknlvmvyddyLKFKEHVSgtKESELAAIRNQKK 808
Cdd:PTZ00121 1241 EAKKAEEERNNEEIRKFEEARMAHFARRQAAI----KAE-EARKADE----------LKKAEEKK--KADEAKKAEEKKK 1303

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    809 AElEAAKKAriEEvrKRRYEEAiaRRKEEianaERQKRAQELAEATRKQREIEEAAAKKSTPYSFRAGNREPPSTPSTLP 888
Cdd:PTZ00121 1304 AD-EAKKKA--EE--AKKADEA--KKKAE----EAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKK 1372

                         330       340
                  ....*....|....*....|....*...
gi 6319553    889 KatvSPDKAKLDMIAQKQREMEEAIEQR 916
Cdd:PTZ00121 1373 K---EEAKKKADAAKKKAEEKKKADEAK 1397
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 583-924 1.12e-04

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 46.37  E-value: 1.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    583 RETLIKKNKDDLEKISKIVDERVKRSQEQKQkhMEHAALHAEQD------------AEVRQQRILEEK----AAI---EA 643
Cdd:NF012221 1513 SNRLEFKGTGHNDGLGYILDNVVATSESSQQ--ADAVSKHAKQDdaaqnaladkerAEADRQRLEQEKqqqlAAIsgsQS 1590

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    644 KLEEEAHRRLIEKKKREFEAIKE--REITKMITEVnakghvyidpneAKSLDldtikQVIIAEVSKNKSELESRMEYAMK 721
Cdd:NF012221 1591 QLESTDQNALETNGQAQRDAILEesRAVTKELTTL------------AQGLD-----ALDSQATYAGESGDQWRNPFAGG 1653

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    722 KLDHTERALRKVELpLLQKEVDKLQETDTANYEAMKKKIvdaAKAEYearmadrknlvmvyddylkfkehvsGTKESEla 801
Cdd:NF012221 1654 LLDRVQEQLDDAKK-ISGKQLADAKQRHVDNQQKVKDAV---AKSEA-------------------------GVAQGE-- 1702

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    802 aiRNQKKAELeAAKKARIEEvrKRRYEEAIARRKEEianAERQKRAQELAEATRKQREIEEAAAKKSTpysfragnrepp 881
Cdd:NF012221 1703 --QNQANAEQ-DIDDAKADA--EKRKDDALAKQNEA---QQAESDANAAANDAQSRGEQDASAAENKA------------ 1762

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 6319553    882 stpstlpkatvspDKAKLDMIAQKQREMEEAIEQRLAGRTAGG 924
Cdd:NF012221 1763 -------------NQAQADAKGAKQDESDKPNRQGAAGSGLSG 1792
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 586-859 3.28e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 44.58  E-value: 3.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553     586 LIKKNKDDLEKISKIVDERVKRSQEQKQKHMEHAALHAEQDAEVRQQRILEEKAAIEAKLEEEAHRRLIEKKKREFEAIK 665
Cdd:pfam02463  235 NEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEE 314

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553     666 EREITKMITEVNAKghvyidpNEAKSLDLDTIKQVIIAEVSKNKSELESRMEYAMKKLDHTERALRKVELpLLQKEVDKL 745
Cdd:pfam02463  315 KLKESEKEKKKAEK-------ELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLA-KKKLESERL 386

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553     746 QETDTANYEAMKKKIVDAAKAEYEARMADRKNlvMVYDDYLKFKEHVSGTKESELAAIRNQKKAELEAAKKARIEEVRKR 825
Cdd:pfam02463  387 SSAAKLKEEELELKSEEEKEAQLLLELARQLE--DLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDE 464

                          250       260       270
                   ....*....|....*....|....*....|....
gi 6319553     826 RYEEAIARRKEEIANAErQKRAQELAEATRKQRE 859
Cdd:pfam02463  465 LELKKSEDLLKETQLVK-LQEQLELLLSRQKLEE 497
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 548-861 7.28e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 43.42  E-value: 7.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553     548 IRNSYIHNKLLELSNVLHDVDSFNNASYMEKVRIARETLIKKNKDDLEKISKIVDERVKRSQEQKQKHMEHAALHAEQDA 627
Cdd:pfam02463  734 INEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEE 813

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553     628 EVRQQRILEEKAAIEAKLEEEAHR---RLIEKKKREFEAIKEREITKMITEVNakghVYIDPNEAKSLDLDTIKQVIIAE 704
Cdd:pfam02463  814 AELLEEEQLLIEQEEKIKEEELEElalELKEEQKLEKLAEEELERLEEEITKE----ELLQELLLKEEELEEQKLKDELE 889

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553     705 VSKNKSELESRMEYAMKKLDHTERALRKVELPLLQKEVDKLQEtdtanYEAMKKKIVDAAKAEYEARMADRKnlvmvydd 784
Cdd:pfam02463  890 SKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLK-----YEEEPEELLLEEADEKEKEENNKE-------- 956

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6319553     785 ylkfkehvsgtKESELAAIRNQKKAELEAAKKARIEEVRKRRYEEAIARRKEEIANAERQKRAQELAEATRKQREIE 861
Cdd:pfam02463  957 -----------EEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQRLKEF 1022
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 573-861 8.60e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.52  E-value: 8.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553     573 ASYMEKVRIARETL--IKKNKDDLEKISKIVDERVKRSQEQKQKHMEHAALHAE-QDAE----VRQQRILE-EKAAIEAK 644
Cdd:TIGR02169  166 AEFDRKKEKALEELeeVEENIERLDLIIDEKRQQLERLRREREKAERYQALLKEkREYEgyelLKEKEALErQKEAIERQ 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553     645 LEEEahRRLIEKKKREFEAIKER--EITKMITEVNAKghvyIDP-NEAKSLDLDTIKQVIIAEVSK---NKSELESRMEY 718
Cdd:TIGR02169  246 LASL--EEELEKLTEEISELEKRleEIEQLLEELNKK----IKDlGEEEQLRVKEKIGELEAEIASlerSIAEKERELED 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553     719 AMKKLDHTERALRKV---------ELPLLQKEVDKLQE---TDTANYEAMKKKIVDAAKAEYEAR---MADRKNLVMVYD 783
Cdd:TIGR02169  320 AEERLAKLEAEIDKLlaeieelerEIEEERKRRDKLTEeyaELKEELEDLRAELEEVDKEFAETRdelKDYREKLEKLKR 399

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553     784 D------YLKFKEHVSGTKESELAAIRNQ------KKAELEAAKKARIEEVRK--------------------------R 825
Cdd:TIGR02169  400 EinelkrELDRLQEELQRLSEELADLNAAiagieaKINELEEEKEDKALEIKKqewkleqlaadlskyeqelydlkeeyD 479

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 6319553     826 RYEEAIARRKEEIANAERQKRAQELAEATRKQREIE 861
Cdd:TIGR02169  480 RVEKELSKLQRELAEAEAQARASEERVRGGRAVEEV 515
MutS2 COG1193
dsDNA-specific endonuclease/ATPase MutS2 [Replication, recombination and repair];
579-672 1.23e-03

dsDNA-specific endonuclease/ATPase MutS2 [Replication, recombination and repair];


Pssm-ID: 440806 [Multi-domain]  Cd Length: 784  Bit Score: 42.82  E-value: 1.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553  579 VRIAREtLIKKNKDDLEK-ISKIvdERVKRSQEQKQKHMEHAALHAE---QDAEVRQQRILEEKAAIEAKLEEEAhRRLI 654
Cdd:COG1193 502 IERARE-LLGEESIDVEKlIEEL--ERERRELEEEREEAERLREELEklrEELEEKLEELEEEKEEILEKAREEA-EEIL 577

                        90
                ....*....|....*...
gi 6319553  655 EKKKREFEAIKeREITKM 672
Cdd:COG1193 578 REARKEAEELI-RELREA 594
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 631-841 1.46e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 42.51  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553   631 QQRILEEKAAIEAKLEEEAhRRLIEKKKREFEAIKEREiTKMITEVNAKGHVYIdpNEAKSLDLDTIKQVIIAEVSKNKS 710
Cdd:PRK00409 528 LERELEQKAEEAEALLKEA-EKLKEELEEKKEKLQEEE-DKLLEEAEKEAQQAI--KEAKKEADEIIKELRQLQKGGYAS 603

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553   711 ELESRMEYAMKKLDhtERALRKVELPLLQKEV-DKLQETDTANYEAMKKK-IVDAAKAEYEarmadrknlVMVYDDYLKF 788
Cdd:PRK00409 604 VKAHELIEARKRLN--KANEKKEKKKKKQKEKqEELKVGDEVKYLSLGQKgEVLSIPDDKE---------AIVQAGIMKM 672

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6319553   789 KEHvsgtkESELAAIRNQKKAELEAAKKARIE--------EVRKRRYEEAIARRKEEIANA 841
Cdd:PRK00409 673 KVP-----LSDLEKIQKPKKKKKKKPKTVKPKprtvslelDLRGMRYEEALERLDKYLDDA 728
PRK00247 PRK00247
putative inner membrane protein translocase component YidC; Validated
 799-889 1.49e-03

putative inner membrane protein translocase component YidC; Validated


Pssm-ID: 178945 [Multi-domain]  Cd Length: 429  Bit Score: 42.15  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553   799 ELAAIRNQKKAELEAAKKARIEEVRKRR-YEEAIARRKEEIANAERQKRAQELAEATRKQREIEEAAAKKSTPYSFRAGN 877
Cdd:PRK00247 328 ENAEIKKTRTAEKNEAKARKKEIAQKRRaAEREINREARQERAAAMARARARRAAVKAKKKGLIDASPNEDTPSENEESK 407

                         90
                 ....*....|..
gi 6319553   878 REPPSTPSTLPK 889
Cdd:PRK00247 408 GSPPQVEATTTA 419
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 576-770 2.19e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.03  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    576 MEKVRIARETLIKKNKDDLEKISKIVDERVKRSQEQKQKHMEHAalhAEQDAEVRQQRILEEKAAIEAKLEEEAHRRLIE 655
Cdd:pfam17380 422 MEQIRAEQEEARQREVRRLEEERAREMERVRLEEQERQQQVERL---RQQEEERKRKKLELEKEKRDRKRAEEQRRKILE 498

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    656 KkkrEFEAIKEreitKMITEVNAKGHVyidpneakSLDLDTIKQVIIAEVSKNKSELESRMEYAMKKLDHTERALRKVel 735
Cdd:pfam17380 499 K---ELEERKQ----AMIEEERKRKLL--------EKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKA-- 561

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 6319553    736 pllQKEVDKLQETDTAnyEAMKKKIVDA--AKAEYEA 770
Cdd:pfam17380 562 ---TEERSRLEAMERE--REMMRQIVESekARAEYEA 593
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 582-859 2.80e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.46  E-value: 2.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553  582 ARETLIKKNKDDLEKISKIVDERVKRSQEQKQKhMEHAALHAEQDAEVRQQRILEEKAAIEAKLEEEAHRRLIEKKKREF 661
Cdd:COG1196 288 AEEYELLAELARLEQDIARLEERRRELEERLEE-LEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEA 366

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553  662 EAIKEREITKMITEVNAKGHVYIDPNEAKSLDLDTIKQVIIAEvsKNKSELESRMEYAMKKLDHTERALRKVELPLLQKE 741
Cdd:COG1196 367 LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAE--EALLERLERLEEELEELEEALAELEEEEEEEEEAL 444

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553  742 VDKLQETDTANYEAMKKKIVDAAKAEYEARMADRKNLVMVYDDYLKFKEHVSGTKESELAAIRNQKKAELEAAKKARIE- 820
Cdd:COG1196 445 EEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAg 524

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 6319553  821 --------EVRKRRYEEAIARRKEEIANAERQKRAQELAEATRKQRE 859
Cdd:COG1196 525 avavligvEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKA 571
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 577-679 4.10e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 40.60  E-value: 4.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553    577 EKVRIARETLIKKNKDDL---EKISKIVDERVKRSQEQKQKHMEHAALHAEQDAEVRQQRILEEKAAIEAKLEEEAhrrl 653
Cdd:TIGR02794  87 EQARQKELEQRAAAEKAAkqaEQAAKQAEEKQKQAEEAKAKQAAEAKAKAEAEAERKAKEEAAKQAEEEAKAKAAA---- 162

                          90       100
                  ....*....|....*....|....*.
gi 6319553    654 IEKKKREFEAIKEREITKMITEVNAK 679
Cdd:TIGR02794 163 EAKKKAEEAKKKAEAEAKAKAEAEAK 188
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 609-867 4.63e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 40.56  E-value: 4.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553   609 QEQKQKHMEHAALHAEQDAEVRQQRILEEKAAIEAKLEEEAHRRLIE---KKKREFEAIKEREITKMITEVNAKGhvyid 685
Cdd:PRK09510  67 QQQQQKSAKRAEEQRKKKEQQQAEELQQKQAAEQERLKQLEKERLAAqeqKKQAEEAAKQAALKQKQAEEAAAKA----- 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553   686 pneaksldldtikqviiAEVSKNKSELESRMEYAMKKldhteralrKVElpllqKEVDKLQEtdtanyEAMKKKIVDAAK 765
Cdd:PRK09510 142 -----------------AAAAKAKAEAEAKRAAAAAK---------KAA-----AEAKKKAE------AEAAKKAAAEAK 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553   766 AEYEARMADRknlvmvyddylkfkehvsgtkeselAAIRNQKKAELEAAKKARIEEVRKrryeeAIARRKEEIANAERQK 845
Cdd:PRK09510 185 KKAEAEAAAK-------------------------AAAEAKKKAEAEAKKKAAAEAKKK-----AAAEAKAAAAKAAAEA 234

                        250       260
                 ....*....|....*....|..
gi 6319553   846 RAQelAEATRKQREIEEAAAKK 867
Cdd:PRK09510 235 KAA--AEKAAAAKAAEKAAAAK 254
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 685-866 4.77e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.52  E-value: 4.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553  685 DPNEAKSLDLDTIKQVI------IAEVSKNKSELESRMEYAMKKLDHTERALRKVE--LPLLQKEVDKLQ---ETDTANY 753
Cdd:COG4942  20 DAAAEAEAELEQLQQEIaelekeLAALKKEEKALLKQLAALERRIAALARRIRALEqeLAALEAELAELEkeiAELRAEL 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553  754 EAMKKKIVDAAKAEYEARMADRKNLVMVYDDYLKFK------EHVSGTKESELAAIR-------------NQKKAELEAA 814
Cdd:COG4942 100 EAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVrrlqylKYLAPARREQAEELRadlaelaalraelEAERAELEAL 179

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 6319553  815 KKARIEEvrKRRYEEAIARRKEEIANAERQKRA--QELAEATRKQREIEEAAAK 866
Cdd:COG4942 180 LAELEEE--RAALEALKAERQKLLARLEKELAElaAELAELQQEAEELEALIAR 231
CCDC66 pfam15236
Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil ...
 804-867 7.52e-03

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.


Pssm-ID: 434558 [Multi-domain]  Cd Length: 154  Bit Score: 38.24  E-value: 7.52e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6319553    804 RNQKKAELEAAKKARIEEVRKRRYEEAIARRKEEIANAERQKRAQE-----LAEATRKQREIEEAAAKK 867
Cdd:pfam15236  50 KRQKALEHQNAIKKQLEEKERQKKLEEERRRQEEQEEEERLRREREeeqkqFEEERRKQKEKEEAMTRK 118
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 703-875 7.58e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 39.79  E-value: 7.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553   703 AEVSKNKSELESRMEYAMKKLDHTERaLRKVELPLLQKEVDKLQETDTANYEAMKKKIV-DAAKAEYEARMADRKNLVMV 781
Cdd:PRK09510  77 AEEQRKKKEQQQAEELQQKQAAEQER-LKQLEKERLAAQEQKKQAEEAAKQAALKQKQAeEAAAKAAAAAKAKAEAEAKR 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319553   782 YDDYLKFKEHVSGTKESELAAIRN----QKKAELEAAKKARIEEVRKRRYEEAIARRKEEIANAERQKRAQELAEATRKQ 857
Cdd:PRK09510 156 AAAAAKKAAAEAKKKAEAEAAKKAaaeaKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAAEAKAAAAKAAAEAK 235

                        170
                 ....*....|....*...
gi 6319553   858 REIEEAAAKKSTPYSFRA 875
Cdd:PRK09510 236 AAAEKAAAAKAAEKAAAA 253
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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